                         SEQUENCE LISTING



<110>  Biogen Idec MA Inc.

       Chhabra, Ekta Seth

       Liu, Tongyao

 

<120>  FACTOR VIII COMPLEX WITH XTEN AND VON WILLEBRAND FACTOR PROTEIN, 

       AND USES THEREOF



<130>  2159.365PC06/EKS/C-K/E-H



<140>  To be assigned

<141>  Herewith



<150>  US 61/840,811

<151>  2013-06-28



<150>  US 61/827,158

<151>  2013-05-24



<150>  US 61/801,544

<151>  2013-03-15



<150>  US 61/801,504

<151>  2013-03-15



<150>  US 61/759,819

<151>  2013-02-01



<150>  US 61/670,401

<151>  2012-07-11



<160>  140   



<170>  PatentIn version 3.5



<210>  1

<211>  8442

<212>  DNA

<213>  Homo sapiens



<400>  1

atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt gccagggacc       60



ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct tttcggaagt      120



gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg cagttacctc      180



ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca gaatggcaag      240



agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt tgtcaatggt      300



accgtgacac agggggacca aagagtctcc atgccctatg cctccaaagg gctgtatcta      360



gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt ggccaggatc      420



gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa gacctgcggg      480



ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga agggaccttg      540



acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga acagtggtgt      600



gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat gcagaagggc      660



ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg ccaccctctg      720



gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg tgctgggggg      780



ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca ggagggaatg      840



gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc tggtatggag      900



tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat caatgaaatg      960



tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct ggatgaaggc     1020



ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta ccctcccggc     1080



acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg gatctgcagc     1140



aatgaagaat gtccagggga gtgccttgtc actggtcaat cccacttcaa gagctttgac     1200



aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga ttgccaggac     1260



cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga cgctgtgtgc     1320



acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa actgaagcat     1380



ggggcaggag ttgccatgga tggccaggac atccagctcc ccctcctgaa aggtgacctc     1440



cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga cctgcagatg     1500



gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctatgc cgggaagacc     1560



tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac cccctctggg     1620



ctggcrgagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg ggactgccag     1680



gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac caggttctcc     1740



gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg tgccgtcagc     1800



ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga cggccgcgag     1860



tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg cgtgcgcgtc     1920



gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt gtacctgcag     1980



tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga ggaatgcaat     2040



gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga gaggggggac     2100



tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca gccagaagac     2160



atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca ctgtaccatg     2220



agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct gtctcatcgc     2280



agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc cgctgacaac     2340



ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct ggagtgcatg     2400



agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca tgagaacaga     2460



tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc ccctggagaa     2520



acagtgaaga ttggctgcaa cacttgtgtc tgtcgggacc ggaagtggaa ctgcacagac     2580



catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac cttcgacggg     2640



ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta ctgcggcagt     2700



aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc ctcagtgaaa     2760



tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt tgacggggag     2820



gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga gtctggccgg     2880



tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca cctgagcatc     2940



tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg gaattttgat     3000



ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga ccctgtggac     3060



tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt gcctctggac     3120



tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga ttcctcctgt     3180



agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc cgagccatat     3240



ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg cgcctgcttc     3300



tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt ggtgacctgg     3360



aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga gaacgggtat     3420



gagtgtgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg tcagcaccct     3480



gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg ccctccaggg     3540



aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc agtgtgtgag     3600



gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag tgaccctgag     3660



cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg ccaggagccg     3720



ggaggcctgg tggtgcctcc cacagatgcc ccggtgagcc ccaccactct gtatgtggag     3780



gacatctcgg aaccgccgtt gcacgatttc tactgcagca ggctactgga cctggtcttc     3840



ctgctggatg gctcctccag gctgtccgag gctgagtttg aagtgctgaa ggcctttgtg     3900



gtggacatga tggagcggct gcgcatctcc cagaagtggg tccgcgtggc cgtggtggag     3960



taccacgacg gctcccacgc ctacatcggg ctcaaggacc ggaagcgacc gtcagagctg     4020



cggcgcattg ccagccaggt gaagtatgcg ggcagccagg tggcctccac cagcgaggtc     4080



ttgaaataca cactgttcca aatcttcagc aagatcgacc gccctgaagc ctcccgcatc     4140



gccctgctcc tgatggccag ccaggagccc caacggatgt cccggaactt tgtccgctac     4200



gtccagggcc tgaagaagaa gaaggtcatt gtgatcccgg tgggcattgg gccccatgcc     4260



aacctcaagc agatccgcct catcgagaag caggcccctg agaacaaggc cttcgtgctg     4320



agcagtgtgg atgagctgga gcagcaaagg gacgagatcg ttagctacct ctgtgacctt     4380



gcccctgaag cccctcctcc tactctgccc cccgacatgg cacaagtcac tgtgggcccg     4440



gggctcttgg gggtttcgac cctggggccc aagaggaact ccatggttct ggatgtggcg     4500



ttcgtcctgg aaggatcgga caaaattggt gaagccgact tcaacaggag caaggagttc     4560



atggaggagg tgattcagcg gatggatgtg ggccaggaca gcatccacgt cacggtgctg     4620



cagtactcct acatggtgac cgtggagtac cccttcagcg aggcacagtc caaaggggac     4680



atcctgcagc gggtgcgaga gatccgctac cagggcggca acaggaccaa cactgggctg     4740



gccctgcggt acctctctga ccacagcttc ttggtcagcc agggtgaccg ggagcaggcg     4800



cccaacctgg tctacatggt caccggaaat cctgcctctg atgagatcaa gaggctgcct     4860



ggagacatcc aggtggtgcc cattggagtg ggccctaatg ccaacgtgca ggagctggag     4920



aggattggct ggcccaatgc ccctatcctc atccaggact ttgagacgct cccccgagag     4980



gctcctgacc tggtgctgca gaggtgctgc tccggagagg ggctgcagat ccccaccctc     5040



tcccctgcac ctgactgcag ccagcccctg gacgtgatcc ttctcctgga tggctcctcc     5100



agtttcccag cttcttattt tgatgaaatg aagagtttcg ccaaggcttt catttcaaaa     5160



gccaatatag ggcctcgtct cactcaggtg tcagtgctgc agtatggaag catcaccacc     5220



attgacgtgc catggaacgt ggtcccggag aaagcccatt tgctgagcct tgtggacgtc     5280



atgcagcggg agggaggccc cagccaaatc ggggatgcct tgggctttgc tgtgcgatac     5340



ttgacttcag aaatgcatgg tgccaggccg ggagcctcaa aggcggtggt catcctggtc     5400



acggacgtct ctgtggattc agtggatgca gcagctgatg ccgccaggtc caacagagtg     5460



acagtgttcc ctattggaat tggagatcgc tacgatgcag cccagctacg gatcttggca     5520



ggcccagcag gcgactccaa cgtggtgaag ctccagcgaa tcgaagacct ccctaccatg     5580



gtcaccttgg gcaattcctt cctccacaaa ctgtgctctg gatttgttag gatttgcatg     5640



gatgaggatg ggaatgagaa gaggcccggg gacgtctgga ccttgccaga ccagtgccac     5700



accgtgactt gccagccaga tggccagacc ttgctgaaga gtcatcgggt caactgtgac     5760



cgggggctga ggccttcgtg ccctaacagc cagtcccctg ttaaagtgga agagacctgt     5820



ggctgccgct ggacctgccc ctgygtgtgc acaggcagct ccactcggca catcgtgacc     5880



tttgatgggc agaatttcaa gctgactggc agctgttctt atgtcctatt tcaaaacaag     5940



gagcaggacc tggaggtgat tctccataat ggtgcctgca gccctggagc aaggcagggc     6000



tgcatgaaat ccatcgaggt gaagcacagt gccctctccg tcgagstgca cagtgacatg     6060



gaggtgacgg tgaatgggag actggtctct gttccttacg tgggtgggaa catggaagtc     6120



aacgtttatg gtgccatcat gcatgaggtc agattcaatc accttggtca catcttcaca     6180



ttcactccac aaaacaatga gttccaactg cagctcagcc ccaagacttt tgcttcaaag     6240



acgtatggtc tgtgtgggat ctgtgatgag aacggagcca atgacttcat gctgagggat     6300



ggcacagtca ccacagactg gaaaacactt gttcaggaat ggactgtgca gcggccaggg     6360



cagacgtgcc agcccatcct ggaggagcag tgtcttgtcc ccgacagctc ccactgccag     6420



gtcctcctct taccactgtt tgctgaatgc cacaaggtcc tggctccagc cacattctat     6480



gccatctgcc agcaggacag ttgccaccag gagcaagtgt gtgaggtgat cgcctcttat     6540



gcccacctct gtcggaccaa cggggtctgc gttgactgga ggacacctga tttctgtgct     6600



atgtcatgcc caccatctct ggtctacaac cactgtgagc atggctgtcc ccggcactgt     6660



gatggcaacg tgagctcctg tggggaccat ccctccgaag gctgtttctg ccctccagat     6720



aaagtcatgt tggaaggcag ctgtgtccct gaagaggcct gcactcagtg cattggtgag     6780



gatggagtcc agcaccagtt cctggaagcc tgggtcccgg accaccagcc ctgtcagatc     6840



tgcacatgcc tcagcgggcg gaaggtcaac tgcacaacgc agccctgccc cacggccaaa     6900



gctcccacgt gtggcctgtg tgaagtagcc cgcctccgcc agaatgcaga ccagtgctgc     6960



cccgagtatg agtgtgtgtg tgacccagtg agctgtgacc tgcccccagt gcctcactgt     7020



gaacgtggcc tccagcccac actgaccaac cctggcgagt gcagacccaa cttcacctgc     7080



gcctgcagga aggaggagtg caaaagagtg tccccaccct cctgcccccc gcaccgtttg     7140



cccacccttc ggaagaccca gtgctgtgat gagtatgagt gtgcctgcaa ctgtgtcaac     7200



tccacagtga gctgtcccct tgggtacttg gcctcaaccg ccaccaatga ctgtggctgt     7260



accacaacca cctgccttcc cgacaaggtg tgtgtccacc gaagcaccat ctaccctgtg     7320



ggccagttct gggaggaggg ctgcgatgtg tgcacctgca ccgacatgga ggatgccgtg     7380



atgggcctcc gcgtggccca gtgctcccag aagccctgtg aggacagctg tcggtcgggc     7440



ttcacttacg ttctgcatga aggcgagtgc tgtggaaggt gcctgccatc tgcctgtgag     7500



gtggtgactg gctcaccgcg gggggactcc cagtcttcct ggaagagtgt cggctcccag     7560



tgggcctccc cggagaaccc ctgcctcatc aatgagtgtg tccgagtgaa ggaggaggtc     7620



tttatacaac aaaggaacgt ctcctgcccc cagctggagg tccctgtctg cccctcgggc     7680



tttcagctga gctgtaagac ctcagcgtgc tgcccaagct gtcgctgtga gcgcatggag     7740



gcctgcatgc tcaatggcac tgtcattggg cccgggaaga ctgtgatgat cgatgtgtgc     7800



acgacctgcc gctgcatggt gcaggtgggg gtcatctctg gattcaagct ggagtgcagg     7860



aagaccacct gcaacccctg ccccctgggt tacaaggaag aaaataacac aggtgaatgt     7920



tgtgggagat gtttgcctac ggcttgcacc attcagctaa gaggaggaca gatcatgaca     7980



ctgaagcgtg atgagacgct ccaggatggc tgtgatactc acttctgcaa ggtcaatgag     8040



agaggagagt acttctggga gaagagggtc acaggctgcc caccctttga tgaacacaag     8100



tgtcttgctg agggaggtaa aattatgaaa attccaggca cctgctgtga cacatgtgag     8160



gagcctgagt gcaacgacat cactgccagg ctgcagtatg tcaaggtggg aagctgtaag     8220



tctgaagtag aggtggatat ccactactgc cagggcaaat gtgccagcaa agccatgtac     8280



tccattgaca tcaacgatgt gcaggaccag tgctcctgct gctctccgac acggacggag     8340



cccatgcagg tggccctgca ctgcaccaat ggctctgttg tgtaccatga ggttctcaat     8400



gccatggagt gcaaatgctc ccccaggaag tgcagcaagt ga                        8442





<210>  2

<211>  2813

<212>  PRT

<213>  Homo sapiens





<220>

<221>  misc_feature

<222>  (1)..(22)

<223>  VWF Signal Peptide



<220>

<221>  misc_feature

<222>  (23)..(763)

<223>  VWF D1D2 region



<220>

<221>  misc_feature

<222>  (764)..(866)

<223>  VWF D'Domain



<220>

<221>  misc_feature

<222>  (867)..(1240)

<223>  VWF D3 Domain



<220>

<221>  misc_feature

<222>  (1241)..(1479)

<223>  VWF A1 Domain



<220>

<221>  misc_feature

<222>  (2016)..(2016)

<223>  Xaa can be any naturally occurring amino acid



<400>  2



Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 

1               5                   10                  15      





Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 

            20                  25                  30          





Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 

        35                  40                  45              





Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 

    50                  55                  60                  





Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 

65                  70                  75                  80  





Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 

                85                  90                  95      





Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 

            100                 105                 110         





Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 

        115                 120                 125             





Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 

    130                 135                 140                 





Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 

145                 150                 155                 160 





Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 

                165                 170                 175     





Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 

            180                 185                 190         





Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 

        195                 200                 205             





Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 

    210                 215                 220                 





Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 

225                 230                 235                 240 





Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 

                245                 250                 255     





Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 

            260                 265                 270         





Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 

        275                 280                 285             





Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 

    290                 295                 300                 





Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 

305                 310                 315                 320 





Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 

                325                 330                 335     





Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 

            340                 345                 350         





Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 

        355                 360                 365             





Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 

    370                 375                 380                 





Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 

385                 390                 395                 400 





Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 

                405                 410                 415     





Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 

            420                 425                 430         





Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 

        435                 440                 445             





Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 

    450                 455                 460                 





Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 

465                 470                 475                 480 





Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 

                485                 490                 495     





Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 

            500                 505                 510         





Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 

        515                 520                 525             





Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 

    530                 535                 540                 





Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 

545                 550                 555                 560 





Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 

                565                 570                 575     





Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 

            580                 585                 590         





Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 

        595                 600                 605             





Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 

    610                 615                 620                 





Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 

625                 630                 635                 640 





Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 

                645                 650                 655     





Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 

            660                 665                 670         





Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 

        675                 680                 685             





Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 

    690                 695                 700                 





Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 

705                 710                 715                 720 





Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 

                725                 730                 735     





His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 

            740                 745                 750         





Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 

        755                 760                 765             





Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 

    770                 775                 780                 





Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 

785                 790                 795                 800 





Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 

                805                 810                 815     





His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 

            820                 825                 830         





Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 

        835                 840                 845             





Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 

    850                 855                 860                 





Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 

865                 870                 875                 880 





Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 

                885                 890                 895     





Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 

            900                 905                 910         





Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 

        915                 920                 925             





Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 

    930                 935                 940                 





Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 

945                 950                 955                 960 





Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 

                965                 970                 975     





His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 

            980                 985                 990         





Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 

        995                 1000                 1005             





Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 

    1010                 1015                 1020             





Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 

    1025                 1030                 1035             





Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 

    1040                 1045                 1050             





Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 

    1055                 1060                 1065             





Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 

    1070                 1075                 1080             





Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 

    1085                 1090                 1095             





Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 

    1100                 1105                 1110             





His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 

    1115                 1120                 1125             





Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 

    1130                 1135                 1140             





Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 

    1145                 1150                 1155             





His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 

    1160                 1165                 1170             





His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 

    1175                 1180                 1185             





Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 

    1190                 1195                 1200             





Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 

    1205                 1210                 1215             





Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 

    1220                 1225                 1230             





Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 

    1235                 1240                 1245             





Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 

    1250                 1255                 1260             





Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 

    1265                 1270                 1275             





Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 

    1280                 1285                 1290             





Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 

    1295                 1300                 1305             





Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 

    1310                 1315                 1320             





Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 

    1325                 1330                 1335             





Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 

    1340                 1345                 1350             





Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 

    1355                 1360                 1365             





Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 

    1370                 1375                 1380             





Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 

    1385                 1390                 1395             





Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 

    1400                 1405                 1410             





Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 

    1415                 1420                 1425             





Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 

    1430                 1435                 1440             





Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 

    1445                 1450                 1455             





Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 

    1460                 1465                 1470             





Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 

    1475                 1480                 1485             





Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 

    1490                 1495                 1500             





Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 

    1505                 1510                 1515             





Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 

    1520                 1525                 1530             





Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 

    1535                 1540                 1545             





Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 

    1550                 1555                 1560             





Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 

    1565                 1570                 1575             





Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 

    1580                 1585                 1590             





Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 

    1595                 1600                 1605             





Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 

    1610                 1615                 1620             





Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 

    1625                 1630                 1635             





Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 

    1640                 1645                 1650             





Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 

    1655                 1660                 1665             





Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 

    1670                 1675                 1680             





Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 

    1685                 1690                 1695             





Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 

    1700                 1705                 1710             





Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 

    1715                 1720                 1725             





Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 

    1730                 1735                 1740             





Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 

    1745                 1750                 1755             





Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 

    1760                 1765                 1770             





Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 

    1775                 1780                 1785             





Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 

    1790                 1795                 1800             





Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 

    1805                 1810                 1815             





Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 

    1820                 1825                 1830             





Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 

    1835                 1840                 1845             





Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 

    1850                 1855                 1860             





Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 

    1865                 1870                 1875             





Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 

    1880                 1885                 1890             





Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 

    1895                 1900                 1905             





Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 

    1910                 1915                 1920             





Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 

    1925                 1930                 1935             





Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 

    1940                 1945                 1950             





Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 

    1955                 1960                 1965             





Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 

    1970                 1975                 1980             





Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 

    1985                 1990                 1995             





Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 

    2000                 2005                 2010             





Val Glu  Xaa His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 

    2015                 2020                 2025             





Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 

    2030                 2035                 2040             





Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 

    2045                 2050                 2055             





Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 

    2060                 2065                 2070             





Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 

    2075                 2080                 2085             





Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 

    2090                 2095                 2100             





Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 

    2105                 2110                 2115             





Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 

    2120                 2125                 2130             





Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 

    2135                 2140                 2145             





Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 

    2150                 2155                 2160             





Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 

    2165                 2170                 2175             





Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 

    2180                 2185                 2190             





Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 

    2195                 2200                 2205             





Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 

    2210                 2215                 2220             





Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 

    2225                 2230                 2235             





Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 

    2240                 2245                 2250             





Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 

    2255                 2260                 2265             





Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 

    2270                 2275                 2280             





Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 

    2285                 2290                 2295             





Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 

    2300                 2305                 2310             





Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 

    2315                 2320                 2325             





Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 

    2330                 2335                 2340             





Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 

    2345                 2350                 2355             





Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 

    2360                 2365                 2370             





Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 

    2375                 2380                 2385             





Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 

    2390                 2395                 2400             





Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 

    2405                 2410                 2415             





Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 

    2420                 2425                 2430             





Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 

    2435                 2440                 2445             





Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 

    2450                 2455                 2460             





Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 

    2465                 2470                 2475             





Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 

    2480                 2485                 2490             





Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 

    2495                 2500                 2505             





Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 

    2510                 2515                 2520             





Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 

    2525                 2530                 2535             





Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 

    2540                 2545                 2550             





Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 

    2555                 2560                 2565             





Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 

    2570                 2575                 2580             





Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 

    2585                 2590                 2595             





Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 

    2600                 2605                 2610             





Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 

    2615                 2620                 2625             





Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 

    2630                 2635                 2640             





Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 

    2645                 2650                 2655             





Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 

    2660                 2665                 2670             





His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 

    2675                 2680                 2685             





Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 

    2690                 2695                 2700             





Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 

    2705                 2710                 2715             





Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 

    2720                 2725                 2730             





Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 

    2735                 2740                 2745             





Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 

    2750                 2755                 2760             





Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 

    2765                 2770                 2775             





Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 

    2780                 2785                 2790             





Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 

    2795                 2800                 2805             





Arg Lys  Cys Ser Lys 

    2810             





<210>  3

<211>  19

<212>  PRT

<213>  Homo sapiens



<400>  3



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser 

            





<210>  4

<211>  2332

<212>  PRT

<213>  Homo sapiens



<400>  4



Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 

1               5                   10                  15      





Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 

            20                  25                  30          





Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 

        35                  40                  45              





Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 

    50                  55                  60                  





Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 

65                  70                  75                  80  





Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 

                85                  90                  95      





Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 

            100                 105                 110         





Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 

        115                 120                 125             





Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 

    130                 135                 140                 





Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 

145                 150                 155                 160 





His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 

                165                 170                 175     





Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 

            180                 185                 190         





His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 

        195                 200                 205             





His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 

    210                 215                 220                 





Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 

225                 230                 235                 240 





Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 

                245                 250                 255     





Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 

            260                 265                 270         





Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 

        275                 280                 285             





Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 

    290                 295                 300                 





Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 

305                 310                 315                 320 





Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 

                325                 330                 335     





Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 

            340                 345                 350         





Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 

        355                 360                 365             





Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 

    370                 375                 380                 





Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 

385                 390                 395                 400 





Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 

                405                 410                 415     





Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 

            420                 425                 430         





Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 

        435                 440                 445             





Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 

    450                 455                 460                 





Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 

465                 470                 475                 480 





Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 

                485                 490                 495     





His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 

            500                 505                 510         





Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 

        515                 520                 525             





Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 

    530                 535                 540                 





Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 

545                 550                 555                 560 





Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 

                565                 570                 575     





Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 

            580                 585                 590         





Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 

        595                 600                 605             





Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 

    610                 615                 620                 





Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 

625                 630                 635                 640 





Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 

                645                 650                 655     





Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 

            660                 665                 670         





Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 

        675                 680                 685             





Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 

    690                 695                 700                 





Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 

705                 710                 715                 720 





Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 

                725                 730                 735     





Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 

            740                 745                 750         





Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 

        755                 760                 765             





Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 

    770                 775                 780                 





Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 

785                 790                 795                 800 





His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 

                805                 810                 815     





Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 

            820                 825                 830         





Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 

        835                 840                 845             





Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 

    850                 855                 860                 





Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 

865                 870                 875                 880 





Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 

                885                 890                 895     





Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 

            900                 905                 910         





Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 

        915                 920                 925             





Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 

    930                 935                 940                 





Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 

945                 950                 955                 960 





Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 

                965                 970                 975     





Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 

            980                 985                 990         





Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 

        995                 1000                 1005             





Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 

    1010                 1015                 1020             





Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 

    1025                 1030                 1035             





Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 

    1040                 1045                 1050             





Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 

    1055                 1060                 1065             





Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 

    1070                 1075                 1080             





Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 

    1085                 1090                 1095             





Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 

    1100                 1105                 1110             





Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 

    1115                 1120                 1125             





Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 

    1130                 1135                 1140             





Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 

    1145                 1150                 1155             





Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 

    1160                 1165                 1170             





Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 

    1175                 1180                 1185             





Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 

    1190                 1195                 1200             





Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 

    1205                 1210                 1215             





Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 

    1220                 1225                 1230             





Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 

    1235                 1240                 1245             





Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 

    1250                 1255                 1260             





His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 

    1265                 1270                 1275             





Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 

    1280                 1285                 1290             





Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 

    1295                 1300                 1305             





Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 

    1310                 1315                 1320             





Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 

    1325                 1330                 1335             





Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 

    1340                 1345                 1350             





Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 

    1355                 1360                 1365             





Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 

    1370                 1375                 1380             





Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 

    1385                 1390                 1395             





Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 

    1400                 1405                 1410             





Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 

    1415                 1420                 1425             





Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 

    1430                 1435                 1440             





Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 

    1445                 1450                 1455             





Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 

    1460                 1465                 1470             





Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 

    1475                 1480                 1485             





Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 

    1490                 1495                 1500             





Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 

    1505                 1510                 1515             





Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 

    1520                 1525                 1530             





Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 

    1535                 1540                 1545             





Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 

    1550                 1555                 1560             





Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 

    1565                 1570                 1575             





Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 

    1580                 1585                 1590             





Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 

    1595                 1600                 1605             





Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 

    1610                 1615                 1620             





Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 

    1625                 1630                 1635             





Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 

    1640                 1645                 1650             





Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 

    1655                 1660                 1665             





Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 

    1670                 1675                 1680             





Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 

    1685                 1690                 1695             





Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 

    1700                 1705                 1710             





Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 

    1715                 1720                 1725             





Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 

    1730                 1735                 1740             





Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 

    1745                 1750                 1755             





Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 

    1760                 1765                 1770             





Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 

    1775                 1780                 1785             





Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 

    1790                 1795                 1800             





Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 

    1805                 1810                 1815             





Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 

    1820                 1825                 1830             





Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 

    1835                 1840                 1845             





Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 

    1850                 1855                 1860             





Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 

    1865                 1870                 1875             





Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 

    1880                 1885                 1890             





Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 

    1895                 1900                 1905             





Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 

    1910                 1915                 1920             





Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 

    1925                 1930                 1935             





Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 

    1940                 1945                 1950             





His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 

    1955                 1960                 1965             





Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 

    1970                 1975                 1980             





Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 

    1985                 1990                 1995             





Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 

    2000                 2005                 2010             





Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 

    2015                 2020                 2025             





Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 

    2030                 2035                 2040             





Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 

    2045                 2050                 2055             





Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 

    2060                 2065                 2070             





Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 

    2075                 2080                 2085             





Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 

    2090                 2095                 2100             





Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 

    2105                 2110                 2115             





Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 

    2120                 2125                 2130             





Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 

    2135                 2140                 2145             





Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 

    2150                 2155                 2160             





Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 

    2165                 2170                 2175             





Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 

    2180                 2185                 2190             





Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 

    2195                 2200                 2205             





Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 

    2210                 2215                 2220             





Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 

    2225                 2230                 2235             





Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 

    2240                 2245                 2250             





Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 

    2255                 2260                 2265             





His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 

    2270                 2275                 2280             





Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 

    2285                 2290                 2295             





Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 

    2300                 2305                 2310             





Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 

    2315                 2320                 2325             





Gln Asp  Leu Tyr 

    2330         





<210>  5

<211>  7053

<212>  DNA

<213>  Homo sapiens



<400>  5

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60



accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120



ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180



acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240



gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300



gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360



ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420



gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480



aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540



gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600



gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660



tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720



gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780



ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840



accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900



cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960



gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020



gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080



gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140



gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200



tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260



cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320



aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380



attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440



ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500



gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560



ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620



actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680



gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740



agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800



aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860



cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920



tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980



attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040



atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100



atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160



atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220



agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280



ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt     2340



ccagaaaatg acatagagaa gactgaccct tggtttgcac acagaacacc tatgcctaaa     2400



atacaaaatg tctcctctag tgatttgttg atgctcttgc gacagagtcc tactccacat     2460



gggctatcct tatctgatct ccaagaagcc aaatatgaga ctttttctga tgatccatca     2520



cctggagcaa tagacagtaa taacagcctg tctgaaatga cacacttcag gccacagctc     2580



catcacagtg gggacatggt atttacccct gagtcaggcc tccaattaag attaaatgag     2640



aaactgggga caactgcagc aacagagttg aagaaacttg atttcaaagt ttctagtaca     2700



tcaaataatc tgatttcaac aattccatca gacaatttgg cagcaggtac tgataataca     2760



agttccttag gacccccaag tatgccagtt cattatgata gtcaattaga taccactcta     2820



tttggcaaaa agtcatctcc ccttactgag tctggtggac ctctgagctt gagtgaagaa     2880



aataatgatt caaagttgtt agaatcaggt ttaatgaata gccaagaaag ttcatgggga     2940



aaaaatgtat cgtcaacaga gagtggtagg ttatttaaag ggaaaagagc tcatggacct     3000



gctttgttga ctaaagataa tgccttattc aaagttagca tctctttgtt aaagacaaac     3060



aaaacttcca ataattcagc aactaataga aagactcaca ttgatggccc atcattatta     3120



attgagaata gtccatcagt ctggcaaaat atattagaaa gtgacactga gtttaaaaaa     3180



gtgacacctt tgattcatga cagaatgctt atggacaaaa atgctacagc tttgaggcta     3240



aatcatatgt caaataaaac tacttcatca aaaaacatgg aaatggtcca acagaaaaaa     3300



gagggcccca ttccaccaga tgcacaaaat ccagatatgt cgttctttaa gatgctattc     3360



ttgccagaat cagcaaggtg gatacaaagg actcatggaa agaactctct gaactctggg     3420



caaggcccca gtccaaagca attagtatcc ttaggaccag aaaaatctgt ggaaggtcag     3480



aatttcttgt ctgagaaaaa caaagtggta gtaggaaagg gtgaatttac aaaggacgta     3540



ggactcaaag agatggtttt tccaagcagc agaaacctat ttcttactaa cttggataat     3600



ttacatgaaa ataatacaca caatcaagaa aaaaaaattc aggaagaaat agaaaagaag     3660



gaaacattaa tccaagagaa tgtagttttg cctcagatac atacagtgac tggcactaag     3720



aatttcatga agaacctttt cttactgagc actaggcaaa atgtagaagg ttcatatgac     3780



ggggcatatg ctccagtact tcaagatttt aggtcattaa atgattcaac aaatagaaca     3840



aagaaacaca cagctcattt ctcaaaaaaa ggggaggaag aaaacttgga aggcttggga     3900



aatcaaacca agcaaattgt agagaaatat gcatgcacca caaggatatc tcctaataca     3960



agccagcaga attttgtcac gcaacgtagt aagagagctt tgaaacaatt cagactccca     4020



ctagaagaaa cagaacttga aaaaaggata attgtggatg acacctcaac ccagtggtcc     4080



aaaaacatga aacatttgac cccgagcacc ctcacacaga tagactacaa tgagaaggag     4140



aaaggggcca ttactcagtc tcccttatca gattgcctta cgaggagtca tagcatccct     4200



caagcaaata gatctccatt acccattgca aaggtatcat catttccatc tattagacct     4260



atatatctga ccagggtcct attccaagac aactcttctc atcttccagc agcatcttat     4320



agaaagaaag attctggggt ccaagaaagc agtcatttct tacaaggagc caaaaaaaat     4380



aacctttctt tagccattct aaccttggag atgactggtg atcaaagaga ggttggctcc     4440



ctggggacaa gtgccacaaa ttcagtcaca tacaagaaag ttgagaacac tgttctcccg     4500



aaaccagact tgcccaaaac atctggcaaa gttgaattgc ttccaaaagt tcacatttat     4560



cagaaggacc tattccctac ggaaactagc aatgggtctc ctggccatct ggatctcgtg     4620



gaagggagcc ttcttcaggg aacagaggga gcgattaagt ggaatgaagc aaacagacct     4680



ggaaaagttc cctttctgag agtagcaaca gaaagctctg caaagactcc ctccaagcta     4740



ttggatcctc ttgcttggga taaccactat ggtactcaga taccaaaaga agagtggaaa     4800



tcccaagaga agtcaccaga aaaaacagct tttaagaaaa aggataccat tttgtccctg     4860



aacgcttgtg aaagcaatca tgcaatagca gcaataaatg agggacaaaa taagcccgaa     4920



atagaagtca cctgggcaaa gcaaggtagg actgaaaggc tgtgctctca aaacccacca     4980



gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa     5040



attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat     5100



gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct     5160



gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg     5220



gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc     5280



tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca     5340



tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt     5400



ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa     5460



cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat     5520



catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt     5580



gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac     5640



acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc     5700



atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct     5760



ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc     5820



aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga     5880



tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat     5940



gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt     6000



gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt     6060



attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt     6120



cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga     6180



caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc     6240



tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt     6300



cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt     6360



atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga     6420



accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac     6480



cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact     6540



cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag     6600



agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc     6660



acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct     6720



caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca     6780



ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc     6840



atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag     6900



gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta     6960



ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg     7020



gaggttctgg gctgcgaggc acaggacctc tac                                  7053





<210>  6

<211>  1438

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  BDDD FVIII



<400>  6



Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 

1               5                   10                  15      





Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 

            20                  25                  30          





Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 

        35                  40                  45              





Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 

    50                  55                  60                  





Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 

65                  70                  75                  80  





Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 

                85                  90                  95      





Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 

            100                 105                 110         





Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 

        115                 120                 125             





Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 

    130                 135                 140                 





Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 

145                 150                 155                 160 





His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 

                165                 170                 175     





Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 

            180                 185                 190         





His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 

        195                 200                 205             





His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 

    210                 215                 220                 





Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 

225                 230                 235                 240 





Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 

                245                 250                 255     





Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 

            260                 265                 270         





Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 

        275                 280                 285             





Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 

    290                 295                 300                 





Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 

305                 310                 315                 320 





Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 

                325                 330                 335     





Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 

            340                 345                 350         





Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 

        355                 360                 365             





Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 

    370                 375                 380                 





Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 

385                 390                 395                 400 





Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 

                405                 410                 415     





Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 

            420                 425                 430         





Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 

        435                 440                 445             





Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 

    450                 455                 460                 





Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 

465                 470                 475                 480 





Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 

                485                 490                 495     





His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 

            500                 505                 510         





Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 

        515                 520                 525             





Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 

    530                 535                 540                 





Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 

545                 550                 555                 560 





Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 

                565                 570                 575     





Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 

            580                 585                 590         





Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 

        595                 600                 605             





Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 

    610                 615                 620                 





Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 

625                 630                 635                 640 





Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 

                645                 650                 655     





Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 

            660                 665                 670         





Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 

        675                 680                 685             





Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 

    690                 695                 700                 





Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 

705                 710                 715                 720 





Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 

                725                 730                 735     





Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 

            740                 745                 750         





Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 

        755                 760                 765             





Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 

    770                 775                 780                 





Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 

785                 790                 795                 800 





Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 

                805                 810                 815     





Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 

            820                 825                 830         





Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 

        835                 840                 845             





Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 

    850                 855                 860                 





Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 

865                 870                 875                 880 





Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 

                885                 890                 895     





Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 

            900                 905                 910         





Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 

        915                 920                 925             





Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 

    930                 935                 940                 





Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 

945                 950                 955                 960 





Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 

                965                 970                 975     





Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 

            980                 985                 990         





Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 

        995                 1000                 1005             





Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 

    1010                 1015                 1020             





Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 

    1025                 1030                 1035             





Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 

    1040                 1045                 1050             





Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 

    1055                 1060                 1065             





Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 

    1070                 1075                 1080             





Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 

    1085                 1090                 1095             





Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 

    1100                 1105                 1110             





Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 

    1115                 1120                 1125             





Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 

    1130                 1135                 1140             





Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 

    1145                 1150                 1155             





Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 

    1160                 1165                 1170             





Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 

    1175                 1180                 1185             





Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 

    1190                 1195                 1200             





Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 

    1205                 1210                 1215             





Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 

    1220                 1225                 1230             





Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 

    1235                 1240                 1245             





Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 

    1250                 1255                 1260             





Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 

    1265                 1270                 1275             





Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 

    1280                 1285                 1290             





Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 

    1295                 1300                 1305             





Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 

    1310                 1315                 1320             





Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 

    1325                 1330                 1335             





Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 

    1340                 1345                 1350             





Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 

    1355                 1360                 1365             





Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 

    1370                 1375                 1380             





Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 

    1385                 1390                 1395             





Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 

    1400                 1405                 1410             





Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 

    1415                 1420                 1425             





Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 

    1430                 1435             





<210>  7

<211>  4371

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  BDDD FVIII



<400>  7

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60



accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120



ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180



acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240



gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300



gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360



ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420



gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480



aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540



gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600



gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660



tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720



gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780



ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840



accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900



cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960



gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020



gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080



gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140



gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200



tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260



cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320



aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380



attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440



ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500



gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560



ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620



actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680



gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740



agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800



aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860



cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920



tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980



attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040



atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100



atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160



atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220



agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280



ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt     2340



cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa     2400



gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca     2460



cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca     2520



catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc     2580



caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat     2640



ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc     2700



agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat     2760



cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac     2820



ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg     2880



gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt     2940



ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa     3000



tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg     3060



gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat     3120



tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct     3180



caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct     3240



attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg     3300



tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt     3360



tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg     3420



gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt     3480



cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat     3540



tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg     3600



ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc     3660



ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat     3720



cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata     3780



aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat     3840



tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc     3900



atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac     3960



tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg     4020



agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag     4080



aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg     4140



tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt     4200



cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac     4260



tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac     4320



cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta c              4371





<210>  8

<211>  25

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  8



Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro Asn Asp Lys Tyr 

1               5                   10                  15      





Glu Pro Phe Trp Glu Asp Glu Glu Lys 

            20                  25  





<210>  9

<211>  4

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  9



Arg Arg Arg Arg 

1               





<210>  10

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  10



Arg Lys Arg Arg Lys Arg 

1               5       





<210>  11

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  11



Arg Arg Arg Arg Ser 

1               5   





<210>  12

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  12



Thr Gln Ser Phe Asn Asp Phe Thr Arg 

1               5                   





<210>  13

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  13



Ser Val Ser Gln Thr Ser Lys Leu Thr Arg 

1               5                   10  





<210>  14

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  14



Asp Phe Leu Ala Glu Gly Gly Gly Val Arg 

1               5                   10  





<210>  15

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  15



Thr Thr Lys Ile Lys Pro Arg 

1               5           





<210>  16

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  16



Leu Val Pro Arg Gly 

1               5   





<210>  17

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  17



Ala Leu Arg Pro Arg 

1               5   





<210>  18

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  18



Lys Leu Thr Arg Ala Glu Thr 

1               5           





<210>  19

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  19



Asp Phe Thr Arg Val Val Gly 

1               5           





<210>  20

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  20



Thr Met Thr Arg Ile Val Gly Gly 

1               5               





<210>  21

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  21



Ser Pro Phe Arg Ser Thr Gly Gly 

1               5               





<210>  22

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  22



Leu Gln Val Arg Ile Val Gly Gly 

1               5               





<210>  23

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  23



Pro Leu Gly Arg Ile Val Gly Gly 

1               5               





<210>  24

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  24



Ile Glu Gly Arg Thr Val Gly Gly 

1               5               





<210>  25

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  25



Leu Thr Pro Arg Ser Leu Leu Val 

1               5               





<210>  26

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  26



Leu Gly Pro Val Ser Gly Val Pro 

1               5               





<210>  27

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  27



Val Ala Gly Asp Ser Leu Glu Glu 

1               5               





<210>  28

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  28



Gly Pro Ala Gly Leu Gly Gly Ala 

1               5               





<210>  29

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  29



Gly Pro Ala Gly Leu Arg Gly Ala 

1               5               





<210>  30

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  30



Ala Pro Leu Gly Leu Arg Leu Arg 

1               5               





<210>  31

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  31



Pro Ala Leu Pro Leu Val Ala Gln 

1               5               





<210>  32

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  32



Glu Asn Leu Tyr Phe Gln Gly 

1               5           





<210>  33

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  33



Asp Asp Asp Lys Ile Val Gly Gly 

1               5               





<210>  34

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  34



Leu Glu Val Leu Phe Gln Gly Pro 

1               5               





<210>  35

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  35



Leu Pro Lys Thr Gly Ser Glu Ser 

1               5               





<210>  36

<211>  42

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE42



<400>  36



Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 

1               5                   10                  15      





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

            20                  25                  30          





Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser 

        35                  40          





<210>  37

<211>  143

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE144



<400>  37



Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 

1               5                   10                  15      





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 

            20                  25                  30          





Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

        35                  40                  45              





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 

    50                  55                  60                  





Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 

65                  70                  75                  80  





Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

                85                  90                  95      





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 

            100                 105                 110         





Ser Ala Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 

        115                 120                 125             





Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

    130                 135                 140             





<210>  38

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AG144



<400>  38



Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

1               5                   10                  15      





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 

            20                  25                  30          





Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 

        35                  40                  45              





Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 

    50                  55                  60                  





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

65                  70                  75                  80  





Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 

                85                  90                  95      





Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 

            100                 105                 110         





Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala 

        115                 120                 125             





Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 

    130                 135                 140                 





<210>  39

<211>  288

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE288



<400>  39



Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

1               5                   10                  15      





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            20                  25                  30          





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

        35                  40                  45              





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 

    50                  55                  60                  





Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 

65                  70                  75                  80  





Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

                85                  90                  95      





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 

            100                 105                 110         





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 

        115                 120                 125             





Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

    130                 135                 140                 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 

145                 150                 155                 160 





Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 

                165                 170                 175     





Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

            180                 185                 190         





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 

        195                 200                 205             





Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 

    210                 215                 220                 





Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

225                 230                 235                 240 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 

                245                 250                 255     





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            260                 265                 270         





Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

        275                 280                 285             





<210>  40

<211>  288

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AG288



<400>  40



Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 

1               5                   10                  15      





Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 

            20                  25                  30          





Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 

        35                  40                  45              





Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 

    50                  55                  60                  





Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 

65                  70                  75                  80  





Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 

                85                  90                  95      





Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 

            100                 105                 110         





Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser 

        115                 120                 125             





Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 

    130                 135                 140                 





Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 

145                 150                 155                 160 





Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser 

                165                 170                 175     





Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 

            180                 185                 190         





Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 

        195                 200                 205             





Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 

    210                 215                 220                 





Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 

225                 230                 235                 240 





Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser 

                245                 250                 255     





Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 

            260                 265                 270         





Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 

        275                 280                 285             





<210>  41

<211>  576

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE576



<400>  41



Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 

1               5                   10                  15      





Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 

            20                  25                  30          





Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

        35                  40                  45              





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

    50                  55                  60                  





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

65                  70                  75                  80  





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

                85                  90                  95      





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 

            100                 105                 110         





Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 

        115                 120                 125             





Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

    130                 135                 140                 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 

145                 150                 155                 160 





Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 

                165                 170                 175     





Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

            180                 185                 190         





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 

        195                 200                 205             





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

    210                 215                 220                 





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

225                 230                 235                 240 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

                245                 250                 255     





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            260                 265                 270         





Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

        275                 280                 285             





Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 

    290                 295                 300                 





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 

305                 310                 315                 320 





Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

                325                 330                 335     





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

            340                 345                 350         





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 

        355                 360                 365             





Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

    370                 375                 380                 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

385                 390                 395                 400 





Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 

                405                 410                 415     





Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

            420                 425                 430         





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

        435                 440                 445             





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

    450                 455                 460                 





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

465                 470                 475                 480 





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 

                485                 490                 495     





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            500                 505                 510         





Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

        515                 520                 525             





Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 

    530                 535                 540                 





Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 

545                 550                 555                 560 





Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

                565                 570                 575     





<210>  42

<211>  576

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AG576



<400>  42



Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 

1               5                   10                  15      





Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser 

            20                  25                  30          





Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 

        35                  40                  45              





Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 

    50                  55                  60                  





Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 

65                  70                  75                  80  





Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 

                85                  90                  95      





Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 

            100                 105                 110         





Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser 

        115                 120                 125             





Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 

    130                 135                 140                 





Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser 

145                 150                 155                 160 





Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 

                165                 170                 175     





Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 

            180                 185                 190         





Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 

        195                 200                 205             





Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 

    210                 215                 220                 





Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 

225                 230                 235                 240 





Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 

                245                 250                 255     





Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 

            260                 265                 270         





Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 

        275                 280                 285             





Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 

    290                 295                 300                 





Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser 

305                 310                 315                 320 





Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 

                325                 330                 335     





Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser 

            340                 345                 350         





Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 

        355                 360                 365             





Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 

    370                 375                 380                 





Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 

385                 390                 395                 400 





Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 

                405                 410                 415     





Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 

            420                 425                 430         





Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro 

        435                 440                 445             





Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 

    450                 455                 460                 





Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 

465                 470                 475                 480 





Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser 

                485                 490                 495     





Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser 

            500                 505                 510         





Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 

        515                 520                 525             





Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 

    530                 535                 540                 





Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser 

545                 550                 555                 560 





Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 

                565                 570                 575     





<210>  43

<211>  864

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE864



<400>  43



Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 

1               5                   10                  15      





Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 

            20                  25                  30          





Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

        35                  40                  45              





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

    50                  55                  60                  





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

65                  70                  75                  80  





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

                85                  90                  95      





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 

            100                 105                 110         





Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 

        115                 120                 125             





Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

    130                 135                 140                 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 

145                 150                 155                 160 





Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 

                165                 170                 175     





Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

            180                 185                 190         





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 

        195                 200                 205             





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

    210                 215                 220                 





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

225                 230                 235                 240 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

                245                 250                 255     





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            260                 265                 270         





Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

        275                 280                 285             





Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 

    290                 295                 300                 





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 

305                 310                 315                 320 





Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

                325                 330                 335     





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

            340                 345                 350         





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 

        355                 360                 365             





Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

    370                 375                 380                 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

385                 390                 395                 400 





Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 

                405                 410                 415     





Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

            420                 425                 430         





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

        435                 440                 445             





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

    450                 455                 460                 





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

465                 470                 475                 480 





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 

                485                 490                 495     





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            500                 505                 510         





Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

        515                 520                 525             





Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 

    530                 535                 540                 





Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 

545                 550                 555                 560 





Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

                565                 570                 575     





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

            580                 585                 590         





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

        595                 600                 605             





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

    610                 615                 620                 





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 

625                 630                 635                 640 





Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 

                645                 650                 655     





Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

            660                 665                 670         





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 

        675                 680                 685             





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 

    690                 695                 700                 





Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

705                 710                 715                 720 





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 

                725                 730                 735     





Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            740                 745                 750         





Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

        755                 760                 765             





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 

    770                 775                 780                 





Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 

785                 790                 795                 800 





Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

                805                 810                 815     





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 

            820                 825                 830         





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

        835                 840                 845             





Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

    850                 855                 860                 





<210>  44

<211>  864

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AG864



<400>  44



Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 

1               5                   10                  15      





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 

            20                  25                  30          





Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 

        35                  40                  45              





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 

    50                  55                  60                  





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

65                  70                  75                  80  





Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 

                85                  90                  95      





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 

            100                 105                 110         





Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

        115                 120                 125             





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

    130                 135                 140                 





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

145                 150                 155                 160 





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

                165                 170                 175     





Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 

            180                 185                 190         





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 

        195                 200                 205             





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 

    210                 215                 220                 





Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 

225                 230                 235                 240 





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 

                245                 250                 255     





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

            260                 265                 270         





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

        275                 280                 285             





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 

    290                 295                 300                 





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

305                 310                 315                 320 





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

                325                 330                 335     





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 

            340                 345                 350         





Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

        355                 360                 365             





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

    370                 375                 380                 





Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 

385                 390                 395                 400 





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

                405                 410                 415     





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

            420                 425                 430         





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

        435                 440                 445             





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

    450                 455                 460                 





Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 

465                 470                 475                 480 





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 

                485                 490                 495     





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

            500                 505                 510         





Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 

        515                 520                 525             





Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 

    530                 535                 540                 





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

545                 550                 555                 560 





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

                565                 570                 575     





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

            580                 585                 590         





Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 

        595                 600                 605             





Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 

    610                 615                 620                 





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

625                 630                 635                 640 





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

                645                 650                 655     





Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 

            660                 665                 670         





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 

        675                 680                 685             





Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 

    690                 695                 700                 





Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 

705                 710                 715                 720 





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 

                725                 730                 735     





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

            740                 745                 750         





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

        755                 760                 765             





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 

    770                 775                 780                 





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

785                 790                 795                 800 





Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 

                805                 810                 815     





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

            820                 825                 830         





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

        835                 840                 845             





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

    850                 855                 860                 





<210>  45

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  45



Thr Gln Ser Phe Asn Asp Phe Thr Arg 

1               5                   





<210>  46

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  46



Ser Val Ser Gln Thr Ser Lys Leu Thr Arg 

1               5                   10  





<210>  47

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  47



Asp Phe Leu Ala Glu Gly Gly Gly Val Arg 

1               5                   10  





<210>  48

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  48



Thr Thr Lys Ile Lys Pro Arg 

1               5           





<210>  49

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  49



Leu Val Pro Arg Gly 

1               5   





<210>  50

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  50



Ala Leu Arg Pro Arg 

1               5   





<210>  51

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  sortase recognition motif





<220>

<221>  misc_feature

<222>  (3)..(3)

<223>  Xaa can be any naturally occurring amino acid



<400>  51



Leu Pro Xaa Thr Gly 

1               5   





<210>  52

<211>  11

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  polypeptide



<400>  52



Pro Lys Asn Ser Ser Met Ile Ser Asn Thr Pro 

1               5                   10      





<210>  53

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  polypeptide



<400>  53



His Gln Ser Leu Gly Thr Gln 

1               5           





<210>  54

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  polypeptide



<400>  54



His Gln Asn Leu Ser Asp Gly Lys 

1               5               





<210>  55

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  polypeptide



<400>  55



His Gln Asn Ile Ser Asp Gly Lys 

1               5               





<210>  56

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  polypeptide



<400>  56



Val Ile Ser Ser His Leu Gly Gln 

1               5               





<210>  57

<211>  4

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker





<220>

<221>  REPEAT

<222>  (1)..(4)

<223>  Repeat from 1 to 100 times



<400>  57



Gly Gly Gly Ser 

1               





<210>  58

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker





<220>

<221>  REPEAT

<222>  (1)..(3)

<223>  May be repeated 1 to 100 times



<220>

<221>  REPEAT

<222>  (4)..(8)

<223>  May be repeated 1 to 100 times



<400>  58



Gly Gly Ser Gly Gly Gly Gly Ser 

1               5               





<210>  59

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker



<400>  59



Ser Gly Gly Ser Gly Gly Ser 

1               5           





<210>  60

<211>  15

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker



<400>  60



Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly 

1               5                   10                  15  





<210>  61

<211>  16

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker



<400>  61



Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 

1               5                   10                  15      





<210>  62

<211>  18

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker



<400>  62



Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 

1               5                   10                  15      





Gly Ser 

        





<210>  63

<211>  15

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker



<400>  63



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 

1               5                   10                  15  





<210>  64

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker





<220>

<221>  REPEAT

<222>  (1)..(5)

<223>  May be repeated 1-20 times



<400>  64



Gly Gly Gly Gly Ser 

1               5   





<210>  65

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  65



Lys Leu Thr Arg Ala Glu Thr 

1               5           





<210>  66

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  66



Asp Phe Thr Arg Val Val Gly 

1               5           





<210>  67

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage Site



<400>  67



Thr Met Thr Arg Ile Val Gly Gly 

1               5               





<210>  68

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  68



Ser Pro Phe Arg Ser Thr Gly Gly 

1               5               





<210>  69

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  69



Leu Gln Val Arg Ile Val Gly Gly 

1               5               





<210>  70

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  70



Pro Leu Gly Arg Ile Val Gly Gly 

1               5               





<210>  71

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  71



Ile Glu Gly Arg Thr Val Gly Gly 

1               5               





<210>  72

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  cleavage site



<400>  72



Leu Thr Pro Arg Ser Leu Leu Val 

1               5               





<210>  73

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  cleavage site



<400>  73



Leu Gly Pro Val Ser Gly Val Pro 

1               5               





<210>  74

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  74



Val Ala Gly Asp Ser Leu Glu Glu 

1               5               





<210>  75

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  75



Gly Pro Ala Gly Leu Gly Gly Ala 

1               5               





<210>  76

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  76



Gly Pro Ala Gly Leu Arg Gly Ala 

1               5               





<210>  77

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  77



Ala Pro Leu Gly Leu Arg Leu Arg 

1               5               





<210>  78

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  78



Pro Ala Leu Pro Leu Val Ala Gln 

1               5               





<210>  79

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (6)..(7)

<223>  Cleavage site



<400>  79



Glu Asn Leu Tyr Phe Gln Gly 

1               5           





<210>  80

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  80



Asp Asp Asp Lys Ile Val Gly Gly 

1               5               





<210>  81

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (6)..(7)

<223>  Cleavage site



<400>  81



Leu Glu Val Leu Phe Gln Gly Pro 

1               5               





<210>  82

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site





<220>

<221>  MISC_FEATURE

<222>  (4)..(5)

<223>  Cleavage site



<400>  82



Leu Pro Lys Thr Gly Ser Glu Ser 

1               5               





<210>  83

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  83



Thr Gln Ser Phe Asn Asp Phe Thr Arg 

1               5                   





<210>  84

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  84



Ser Val Ser Gln Thr Ser Lys Leu Thr Arg 

1               5                   10  





<210>  85

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  85



Asp Phe Leu Ala Glu Gly Gly Gly Val Arg 

1               5                   10  





<210>  86

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  86



Thr Thr Lys Ile Lys Pro Arg 

1               5           





<210>  87

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  87



Leu Val Pro Arg Gly 

1               5   





<210>  88

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  cleavage site



<400>  88



Ala Leu Arg Pro Arg Val Val Gly Gly Ala 

1               5                   10  





<210>  89

<211>  1896

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  FVIII 198



<400>  89



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 

        35                  40                  45              





Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 

    50                  55                  60                  





Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 

65                  70                  75                  80  





Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 

                85                  90                  95      





Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 

            100                 105                 110         





His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 

        115                 120                 125             





Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 

    130                 135                 140                 





Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 

145                 150                 155                 160 





Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 

                165                 170                 175     





Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 

            180                 185                 190         





Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 

        195                 200                 205             





Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 

    210                 215                 220                 





Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 

225                 230                 235                 240 





Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 

                245                 250                 255     





Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 

            260                 265                 270         





Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 

        275                 280                 285             





Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 

    290                 295                 300                 





Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 

305                 310                 315                 320 





Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 

                325                 330                 335     





Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 

            340                 345                 350         





Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 

        355                 360                 365             





Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 

    370                 375                 380                 





Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 

385                 390                 395                 400 





Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 

                405                 410                 415     





Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 

            420                 425                 430         





Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 

        435                 440                 445             





Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 

    450                 455                 460                 





Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 

465                 470                 475                 480 





Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 

                485                 490                 495     





His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 

            500                 505                 510         





Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 

        515                 520                 525             





Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 

    530                 535                 540                 





Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 

545                 550                 555                 560 





Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 

                565                 570                 575     





Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 

            580                 585                 590         





Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 

        595                 600                 605             





Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 

    610                 615                 620                 





Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 

625                 630                 635                 640 





Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 

                645                 650                 655     





Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 

            660                 665                 670         





Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 

        675                 680                 685             





Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 

    690                 695                 700                 





Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 

705                 710                 715                 720 





Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 

                725                 730                 735     





Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 

            740                 745                 750         





Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 

        755                 760                 765             





Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 

    770                 775                 780                 





Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 

785                 790                 795                 800 





Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 

                805                 810                 815     





Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 

            820                 825                 830         





Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 

        835                 840                 845             





Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 

    850                 855                 860                 





Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 

865                 870                 875                 880 





Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 

                885                 890                 895     





Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 

            900                 905                 910         





Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 

        915                 920                 925             





Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 

    930                 935                 940                 





Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 

945                 950                 955                 960 





Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 

                965                 970                 975     





Ser Ser Trp Gly Lys Asn Val Ser Ser Glu Ile Thr Arg Thr Thr Leu 

            980                 985                 990         





Gln Ser Asp Gln Glu Glu Ile Asp  Tyr Asp Asp Thr Ile  Ser Val Glu 

        995                 1000                 1005             





Met Lys  Lys Glu Asp Phe Asp  Ile Tyr Asp Glu Asp  Glu Asn Gln 

    1010                 1015                 1020             





Ser Pro  Arg Ser Phe Gln Lys  Lys Thr Arg His Tyr  Phe Ile Ala 

    1025                 1030                 1035             





Ala Val  Glu Arg Leu Trp Asp  Tyr Gly Met Ser Ser  Ser Pro His 

    1040                 1045                 1050             





Val Leu  Arg Asn Arg Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys 

    1055                 1060                 1065             





Lys Val  Val Phe Gln Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro 

    1070                 1075                 1080             





Leu Tyr  Arg Gly Glu Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro 

    1085                 1090                 1095             





Tyr Ile  Arg Ala Glu Val Glu  Asp Asn Ile Met Val  Thr Phe Arg 

    1100                 1105                 1110             





Asn Gln  Ala Ser Arg Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser 

    1115                 1120                 1125             





Tyr Glu  Glu Asp Gln Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe 

    1130                 1135                 1140             





Val Lys  Pro Asn Glu Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His 

    1145                 1150                 1155             





His Met  Ala Pro Thr Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala 

    1160                 1165                 1170             





Tyr Phe  Ser Asp Val Asp Leu  Glu Lys Asp Val His  Ser Gly Leu 

    1175                 1180                 1185             





Ile Gly  Pro Leu Leu Val Cys  His Thr Asn Thr Leu  Asn Pro Ala 

    1190                 1195                 1200             





His Gly  Arg Gln Val Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr 

    1205                 1210                 1215             





Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu 

    1220                 1225                 1230             





Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr 

    1235                 1240                 1245             





Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile Asn Gly  Tyr Ile Met 

    1250                 1255                 1260             





Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg 

    1265                 1270                 1275             





Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu Asn Ile  His Ser Ile 

    1280                 1285                 1290             





His Phe  Ser Gly His Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr 

    1295                 1300                 1305             





Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val 

    1310                 1315                 1320             





Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu 

    1325                 1330                 1335             





Ile Gly  Glu His Leu His Ala  Gly Met Ser Thr Leu  Phe Leu Val 

    1340                 1345                 1350             





Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly Met Ala  Ser Gly His 

    1355                 1360                 1365             





Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp 

    1370                 1375                 1380             





Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala 

    1385                 1390                 1395             





Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu 

    1400                 1405                 1410             





Ala Pro  Met Ile Ile His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln 

    1415                 1420                 1425             





Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser 

    1430                 1435                 1440             





Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly 

    1445                 1450                 1455             





Thr Leu  Met Val Phe Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys 

    1460                 1465                 1470             





His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu 

    1475                 1480                 1485             





His Pro  Thr His Tyr Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu 

    1490                 1495                 1500             





Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu 

    1505                 1510                 1515             





Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe 

    1520                 1525                 1530             





Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser Lys Ala  Arg Leu His 

    1535                 1540                 1545             





Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro 

    1550                 1555                 1560             





Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys Thr Met  Lys Val Thr 

    1565                 1570                 1575             





Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr 

    1580                 1585                 1590             





Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln Asp Gly  His Gln Trp 

    1595                 1600                 1605             





Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn 

    1610                 1615                 1620             





Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu 

    1625                 1630                 1635             





Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln Ser Trp  Val His Gln 

    1640                 1645                 1650             





Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys Glu Ala  Gln Asp Leu 

    1655                 1660                 1665             





Tyr Asp  Lys Thr His Thr Cys  Pro Pro Cys Pro Ala  Pro Glu Leu 

    1670                 1675                 1680             





Leu Gly  Gly Pro Ser Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp 

    1685                 1690                 1695             





Thr Leu  Met Ile Ser Arg Thr  Pro Glu Val Thr Cys  Val Val Val 

    1700                 1705                 1710             





Asp Val  Ser His Glu Asp Pro  Glu Val Lys Phe Asn  Trp Tyr Val 

    1715                 1720                 1725             





Asp Gly  Val Glu Val His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu 

    1730                 1735                 1740             





Gln Tyr  Asn Ser Thr Tyr Arg  Val Val Ser Val Leu  Thr Val Leu 

    1745                 1750                 1755             





His Gln  Asp Trp Leu Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser 

    1760                 1765                 1770             





Asn Lys  Ala Leu Pro Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala 

    1775                 1780                 1785             





Lys Gly  Gln Pro Arg Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser 

    1790                 1795                 1800             





Arg Asp  Glu Leu Thr Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val 

    1805                 1810                 1815             





Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn 

    1820                 1825                 1830             





Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp 

    1835                 1840                 1845             





Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys 

    1850                 1855                 1860             





Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser Cys Ser  Val Met His 

    1865                 1870                 1875             





Glu Ala  Leu His Asn His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser 

    1880                 1885                 1890             





Pro Gly  Lys 

    1895     





<210>  90

<211>  99

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  ESC48- Fwd - VWF-D'D3 with VIII signal and BsiW1 site



<400>  90

tcgcgacgta cggccgccac catgcaaata gagctctcca cctgcttctt tctgtgcctt       60



ttgcgattct gctttagcct atcctgtcgg ccccccatg                              99





<210>  91

<211>  74

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  ESC51- Rev- VWF D'D3 (1-477 amino acid) with 6His and Not 1 site



<400>  91

tgacctcgag cggccgctca gtggtgatgg tgatgatgcg gctcctggca ggcttcacag       60



gtgaggttga caac                                                         74





<210>  92

<211>  32

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  ESC 89-fwd with Nhe1site



<400>  92

ctcactatag ggagacccaa gctggctagc cg                                     32





<210>  93

<211>  43

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  ESC 91-rev with Sal1



<400>  93

ctggatcccg ggagtcgact cgtcagtggt gatggtgatg atg                         43





<210>  94

<211>  40

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker



<400>  94



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 

1               5                   10                  15      





Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 

            20                  25                  30          





Gly Gly Ser Gly Gly Gly Gly Ser 

        35                  40  





<210>  95

<211>  92

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  LW 22-FWD-VWF-D'D3 with FVIII signal sequence and BsiW1 site



<400>  95

gcgccggccg tacgatgcaa atagagctct ccacctgctt ctttctgtgc cttttgcgat       60



tctgctttag cctatcctgt cggcccccca tg                                     92





<210>  96

<211>  47

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  LW 23-Rev- Fc with stop codon and Not1 site



<400>  96

tcatcaatgt atcttatcat gtctgaattc gcggccgctc atttacc                     47





<210>  97

<211>  41

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  LW24- Fwd- VWF D1D2D'D3 cloning oligo with BsiW1 site



<400>  97

gcgccggccg tacgatgatt cctgccagat ttgccggggt g                           41





<210>  98

<211>  41

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  LW27-Rev-VWF  D'D3 oligo with EcoRV



<400>  98

ccaccgccag atatcggctc ctggcaggct tcacaggtga g                           41





<210>  99

<211>  1240

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  VWF-D1D2D'D3 protein sequence 1



<400>  99



Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 

1               5                   10                  15      





Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 

            20                  25                  30          





Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 

        35                  40                  45              





Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 

    50                  55                  60                  





Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 

65                  70                  75                  80  





Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 

                85                  90                  95      





Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 

            100                 105                 110         





Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 

        115                 120                 125             





Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 

    130                 135                 140                 





Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 

145                 150                 155                 160 





Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 

                165                 170                 175     





Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 

            180                 185                 190         





Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 

        195                 200                 205             





Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 

    210                 215                 220                 





Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 

225                 230                 235                 240 





Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 

                245                 250                 255     





Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 

            260                 265                 270         





Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 

        275                 280                 285             





Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 

    290                 295                 300                 





Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 

305                 310                 315                 320 





Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 

                325                 330                 335     





Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 

            340                 345                 350         





Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 

        355                 360                 365             





Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 

    370                 375                 380                 





Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 

385                 390                 395                 400 





Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 

                405                 410                 415     





Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 

            420                 425                 430         





Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 

        435                 440                 445             





Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 

    450                 455                 460                 





Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 

465                 470                 475                 480 





Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 

                485                 490                 495     





Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 

            500                 505                 510         





Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 

        515                 520                 525             





Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 

    530                 535                 540                 





Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 

545                 550                 555                 560 





Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 

                565                 570                 575     





Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 

            580                 585                 590         





Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 

        595                 600                 605             





Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 

    610                 615                 620                 





Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 

625                 630                 635                 640 





Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 

                645                 650                 655     





Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 

            660                 665                 670         





Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 

        675                 680                 685             





Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 

    690                 695                 700                 





Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 

705                 710                 715                 720 





Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 

                725                 730                 735     





His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 

            740                 745                 750         





Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 

        755                 760                 765             





Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 

    770                 775                 780                 





Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 

785                 790                 795                 800 





Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 

                805                 810                 815     





His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 

            820                 825                 830         





Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 

        835                 840                 845             





Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 

    850                 855                 860                 





Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 

865                 870                 875                 880 





Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 

                885                 890                 895     





Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 

            900                 905                 910         





Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 

        915                 920                 925             





Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 

    930                 935                 940                 





Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 

945                 950                 955                 960 





Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 

                965                 970                 975     





His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 

            980                 985                 990         





Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 

        995                 1000                 1005             





Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 

    1010                 1015                 1020             





Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 

    1025                 1030                 1035             





Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 

    1040                 1045                 1050             





Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 

    1055                 1060                 1065             





Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 

    1070                 1075                 1080             





Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 

    1085                 1090                 1095             





Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 

    1100                 1105                 1110             





His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 

    1115                 1120                 1125             





Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 

    1130                 1135                 1140             





Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 

    1145                 1150                 1155             





His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 

    1160                 1165                 1170             





His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 

    1175                 1180                 1185             





Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 

    1190                 1195                 1200             





Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 

    1205                 1210                 1215             





Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 

    1220                 1225                 1230             





Cys Glu  Ala Cys Gln Glu Pro  

    1235                 1240 





<210>  100

<211>  477

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  VWF-D'D3 protein sequence 2



<400>  100



Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 

1               5                   10                  15      





Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 

            20                  25                  30          





Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 

        35                  40                  45              





Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 

    50                  55                  60                  





Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 

65                  70                  75                  80  





Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 

                85                  90                  95      





Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr 

            100                 105                 110         





Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr 

        115                 120                 125             





Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile 

    130                 135                 140                 





Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys 

145                 150                 155                 160 





Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly 

                165                 170                 175     





Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu Val 

            180                 185                 190         





Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser 

        195                 200                 205             





Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln Thr 

    210                 215                 220                 





Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln 

225                 230                 235                 240 





Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val 

                245                 250                 255     





Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg 

            260                 265                 270         





Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met 

        275                 280                 285             





Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val 

    290                 295                 300                 





Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val 

305                 310                 315                 320 





Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys 

                325                 330                 335     





Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly 

            340                 345                 350         





Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu 

        355                 360                 365             





Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn 

    370                 375                 380                 





Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu 

385                 390                 395                 400 





Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro Pro 

                405                 410                 415     





Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp 

            420                 425                 430         





Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys 

        435                 440                 445             





Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His Cys 

    450                 455                 460                 





Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro 

465                 470                 475         





<210>  101

<211>  2754

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN-FVIII-161



<400>  101



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 

        35                  40                  45              





Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 

    50                  55                  60                  





Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 

65                  70                  75                  80  





Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 

                85                  90                  95      





Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 

            100                 105                 110         





His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 

        115                 120                 125             





Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 

    130                 135                 140                 





Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 

145                 150                 155                 160 





Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 

                165                 170                 175     





Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 

            180                 185                 190         





Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 

        195                 200                 205             





Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 

    210                 215                 220                 





Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 

225                 230                 235                 240 





Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 

                245                 250                 255     





Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 

            260                 265                 270         





Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 

        275                 280                 285             





Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 

    290                 295                 300                 





Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 

305                 310                 315                 320 





Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 

                325                 330                 335     





Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 

            340                 345                 350         





Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 

        355                 360                 365             





Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 

    370                 375                 380                 





Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 

385                 390                 395                 400 





Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 

                405                 410                 415     





Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 

            420                 425                 430         





Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 

        435                 440                 445             





Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 

    450                 455                 460                 





Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 

465                 470                 475                 480 





Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 

                485                 490                 495     





His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 

            500                 505                 510         





Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 

        515                 520                 525             





Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 

    530                 535                 540                 





Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 

545                 550                 555                 560 





Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 

                565                 570                 575     





Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 

            580                 585                 590         





Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 

        595                 600                 605             





Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 

    610                 615                 620                 





Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 

625                 630                 635                 640 





Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 

                645                 650                 655     





Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 

            660                 665                 670         





Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 

        675                 680                 685             





Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 

    690                 695                 700                 





Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 

705                 710                 715                 720 





Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 

                725                 730                 735     





Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 

            740                 745                 750         





Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 

        755                 760                 765             





Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 

    770                 775                 780                 





Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 

785                 790                 795                 800 





Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 

                805                 810                 815     





Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 

            820                 825                 830         





Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 

        835                 840                 845             





Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 

    850                 855                 860                 





Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 

865                 870                 875                 880 





Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 

                885                 890                 895     





Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 

            900                 905                 910         





Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 

        915                 920                 925             





Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 

    930                 935                 940                 





Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 

945                 950                 955                 960 





Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 

                965                 970                 975     





Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 

            980                 985                 990         





Gly Arg Gln Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 

        995                 1000                 1005             





Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 

    1010                 1015                 1020             





Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 

    1025                 1030                 1035             





Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 

    1040                 1045                 1050             





Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 

    1055                 1060                 1065             





Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 

    1070                 1075                 1080             





Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 

    1085                 1090                 1095             





Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 

    1100                 1105                 1110             





Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 

    1115                 1120                 1125             





Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 

    1130                 1135                 1140             





Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 

    1145                 1150                 1155             





Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 

    1160                 1165                 1170             





Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 

    1175                 1180                 1185             





Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 

    1190                 1195                 1200             





Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 

    1205                 1210                 1215             





Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 

    1220                 1225                 1230             





Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 

    1235                 1240                 1245             





Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 

    1250                 1255                 1260             





Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 

    1265                 1270                 1275             





Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 

    1280                 1285                 1290             





Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 

    1295                 1300                 1305             





Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 

    1310                 1315                 1320             





Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 

    1325                 1330                 1335             





Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 

    1340                 1345                 1350             





Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 

    1355                 1360                 1365             





Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 

    1370                 1375                 1380             





Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 

    1385                 1390                 1395             





Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 

    1400                 1405                 1410             





Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 

    1415                 1420                 1425             





Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 

    1430                 1435                 1440             





Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Asp 

    1445                 1450                 1455             





Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 

    1460                 1465                 1470             





Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 

    1475                 1480                 1485             





Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 

    1490                 1495                 1500             





Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 

    1505                 1510                 1515             





Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 

    1520                 1525                 1530             





Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 

    1535                 1540                 1545             





Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 

    1550                 1555                 1560             





Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 

    1565                 1570                 1575             





Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 

    1580                 1585                 1590             





Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 

    1595                 1600                 1605             





Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 

    1610                 1615                 1620             





Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 

    1625                 1630                 1635             





Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 

    1640                 1645                 1650             





Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 

    1655                 1660                 1665             





Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 

    1670                 1675                 1680             





Lys Arg  Arg Arg Arg Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 

    1685                 1690                 1695             





Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 

    1700                 1705                 1710             





Ser Gly  Gly Gly Gly Ser Arg  Lys Arg Arg Lys Arg  Ser Leu Ser 

    1715                 1720                 1725             





Cys Arg  Pro Pro Met Val Lys  Leu Val Cys Pro Ala  Asp Asn Leu 

    1730                 1735                 1740             





Arg Ala  Glu Gly Leu Glu Cys  Thr Lys Thr Cys Gln  Asn Tyr Asp 

    1745                 1750                 1755             





Leu Glu  Cys Met Ser Met Gly  Cys Val Ser Gly Cys  Leu Cys Pro 

    1760                 1765                 1770             





Pro Gly  Met Val Arg His Glu  Asn Arg Cys Val Ala  Leu Glu Arg 

    1775                 1780                 1785             





Cys Pro  Cys Phe His Gln Gly  Lys Glu Tyr Ala Pro  Gly Glu Thr 

    1790                 1795                 1800             





Val Lys  Ile Gly Cys Asn Thr  Cys Val Cys Arg Asp  Arg Lys Trp 

    1805                 1810                 1815             





Asn Cys  Thr Asp His Val Cys  Asp Ala Thr Cys Ser  Thr Ile Gly 

    1820                 1825                 1830             





Met Ala  His Tyr Leu Thr Phe  Asp Gly Leu Lys Tyr  Leu Phe Pro 

    1835                 1840                 1845             





Gly Glu  Cys Gln Tyr Val Leu  Val Gln Asp Tyr Cys  Gly Ser Asn 

    1850                 1855                 1860             





Pro Gly  Thr Phe Arg Ile Leu  Val Gly Asn Lys Gly  Cys Ser His 

    1865                 1870                 1875             





Pro Ser  Val Lys Cys Lys Lys  Arg Val Thr Ile Leu  Val Glu Gly 

    1880                 1885                 1890             





Gly Glu  Ile Glu Leu Phe Asp  Gly Glu Val Asn Val  Lys Arg Pro 

    1895                 1900                 1905             





Met Lys  Asp Glu Thr His Phe  Glu Val Val Glu Ser  Gly Arg Tyr 

    1910                 1915                 1920             





Ile Ile  Leu Leu Leu Gly Lys  Ala Leu Ser Val Val  Trp Asp Arg 

    1925                 1930                 1935             





His Leu  Ser Ile Ser Val Val  Leu Lys Gln Thr Tyr  Gln Glu Lys 

    1940                 1945                 1950             





Val Cys  Gly Leu Cys Gly Asn  Phe Asp Gly Ile Gln  Asn Asn Asp 

    1955                 1960                 1965             





Leu Thr  Ser Ser Asn Leu Gln  Val Glu Glu Asp Pro  Val Asp Phe 

    1970                 1975                 1980             





Gly Asn  Ser Trp Lys Val Ser  Ser Gln Cys Ala Asp  Thr Arg Lys 

    1985                 1990                 1995             





Val Pro  Leu Asp Ser Ser Pro  Ala Thr Cys His Asn  Asn Ile Met 

    2000                 2005                 2010             





Lys Gln  Thr Met Val Asp Ser  Ser Cys Arg Ile Leu  Thr Ser Asp 

    2015                 2020                 2025             





Val Phe  Gln Asp Cys Asn Lys  Leu Val Asp Pro Glu  Pro Tyr Leu 

    2030                 2035                 2040             





Asp Val  Cys Ile Tyr Asp Thr  Cys Ser Cys Glu Ser  Ile Gly Asp 

    2045                 2050                 2055             





Cys Ala  Ala Phe Cys Asp Thr  Ile Ala Ala Tyr Ala  His Val Cys 

    2060                 2065                 2070             





Ala Gln  His Gly Lys Val Val  Thr Trp Arg Thr Ala  Thr Leu Cys 

    2075                 2080                 2085             





Pro Gln  Ser Cys Glu Glu Arg  Asn Leu Arg Glu Asn  Gly Tyr Glu 

    2090                 2095                 2100             





Ala Glu  Trp Arg Tyr Asn Ser  Cys Ala Pro Ala Cys  Gln Val Thr 

    2105                 2110                 2115             





Cys Gln  His Pro Glu Pro Leu  Ala Cys Pro Val Gln  Cys Val Glu 

    2120                 2125                 2130             





Gly Cys  His Ala His Cys Pro  Pro Gly Lys Ile Leu  Asp Glu Leu 

    2135                 2140                 2145             





Leu Gln  Thr Cys Val Asp Pro  Glu Asp Cys Pro Val  Cys Glu Val 

    2150                 2155                 2160             





Ala Gly  Arg Arg Phe Ala Ser  Gly Lys Lys Val Thr  Leu Asn Pro 

    2165                 2170                 2175             





Ser Asp  Pro Glu His Cys Gln  Ile Cys His Cys Asp  Val Val Asn 

    2180                 2185                 2190             





Leu Thr  Cys Glu Ala Cys Gln  Glu Pro Ile Ser Gly  Thr Ser Glu 

    2195                 2200                 2205             





Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Ser Glu Pro  Ala Thr Ser 

    2210                 2215                 2220             





Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 

    2225                 2230                 2235             





Gly Pro  Gly Ser Glu Pro Ala  Thr Ser Gly Ser Glu  Thr Pro Gly 

    2240                 2245                 2250             





Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly Pro Gly  Thr Ser Thr 

    2255                 2260                 2265             





Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ser Pro Ala  Gly Ser Pro 

    2270                 2275                 2280             





Thr Ser  Thr Glu Glu Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 

    2285                 2290                 2295             





Gly Pro  Gly Ser Glu Pro Ala  Thr Ser Gly Ser Glu  Thr Pro Gly 

    2300                 2305                 2310             





Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly Pro Gly  Ser Pro Ala 

    2315                 2320                 2325             





Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Ser Pro Ala  Gly Ser Pro 

    2330                 2335                 2340             





Thr Ser  Thr Glu Glu Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser 

    2345                 2350                 2355             





Ala Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 

    2360                 2365                 2370             





Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly Pro Gly  Thr Ser Glu 

    2375                 2380                 2385             





Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Ser Glu Pro  Ala Thr Ser 

    2390                 2395                 2400             





Gly Ser  Glu Thr Pro Gly Ser  Glu Pro Ala Thr Ser  Gly Ser Glu 

    2405                 2410                 2415             





Thr Pro  Gly Ser Pro Ala Gly  Ser Pro Thr Ser Thr  Glu Glu Gly 

    2420                 2425                 2430             





Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Thr Ser Thr 

    2435                 2440                 2445             





Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ser Glu Pro  Ala Thr Ser 

    2450                 2455                 2460             





Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 

    2465                 2470                 2475             





Gly Pro  Gly Thr Ser Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Asp 

    2480                 2485                 2490             





Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 

    2495                 2500                 2505             





Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Leu  Val Pro Arg 

    2510                 2515                 2520             





Gly Ser  Gly Gly Asp Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala 

    2525                 2530                 2535             





Pro Glu  Leu Leu Gly Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys 

    2540                 2545                 2550             





Pro Lys  Asp Thr Leu Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys 

    2555                 2560                 2565             





Val Val  Val Asp Val Ser His  Glu Asp Pro Glu Val  Lys Phe Asn 

    2570                 2575                 2580             





Trp Tyr  Val Asp Gly Val Glu  Val His Asn Ala Lys  Thr Lys Pro 

    2585                 2590                 2595             





Arg Glu  Glu Gln Tyr Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu 

    2600                 2605                 2610             





Thr Val  Leu His Gln Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys 

    2615                 2620                 2625             





Lys Val  Ser Asn Lys Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile 

    2630                 2635                 2640             





Ser Lys  Ala Lys Gly Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu 

    2645                 2650                 2655             





Pro Pro  Ser Arg Asp Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr 

    2660                 2665                 2670             





Cys Leu  Val Lys Gly Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp 

    2675                 2680                 2685             





Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 

    2690                 2695                 2700             





Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 

    2705                 2710                 2715             





Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 

    2720                 2725                 2730             





Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 

    2735                 2740                 2745             





Ser Leu  Ser Pro Gly Lys 

    2750                 





<210>  102

<211>  2242

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN-FVIII-170 protein sequence



<400>  102



Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 

1               5                   10                  15      





Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 

            20                  25                  30          





Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 

        35                  40                  45              





Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 

    50                  55                  60                  





Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 

65                  70                  75                  80  





Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 

                85                  90                  95      





Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr 

            100                 105                 110         





Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr 

        115                 120                 125             





Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile 

    130                 135                 140                 





Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys 

145                 150                 155                 160 





Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly 

                165                 170                 175     





Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu Val 

            180                 185                 190         





Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser 

        195                 200                 205             





Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln Thr 

    210                 215                 220                 





Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln 

225                 230                 235                 240 





Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val 

                245                 250                 255     





Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg 

            260                 265                 270         





Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met 

        275                 280                 285             





Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val 

    290                 295                 300                 





Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val 

305                 310                 315                 320 





Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Ala 

                325                 330                 335     





Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly 

            340                 345                 350         





Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu 

        355                 360                 365             





Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Ala Glu Trp Arg Tyr Asn 

    370                 375                 380                 





Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu 

385                 390                 395                 400 





Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro Pro 

                405                 410                 415     





Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp 

            420                 425                 430         





Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys 

        435                 440                 445             





Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His Cys 

    450                 455                 460                 





Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Ile Ser Gly 

465                 470                 475                 480 





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

                485                 490                 495     





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

            500                 505                 510         





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

        515                 520                 525             





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 

    530                 535                 540                 





Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

545                 550                 555                 560 





Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

                565                 570                 575     





Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 

            580                 585                 590         





Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

        595                 600                 605             





Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 

    610                 615                 620                 





Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 

625                 630                 635                 640 





Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

                645                 650                 655     





Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

            660                 665                 670         





Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 

        675                 680                 685             





Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

    690                 695                 700                 





Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

705                 710                 715                 720 





Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 

                725                 730                 735     





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

            740                 745                 750         





Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Asp 

        755                 760                 765             





Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 

    770                 775                 780                 





Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 

785                 790                 795                 800 





Gly Gly Ala Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu 

                805                 810                 815     





Ser Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala 

            820                 825                 830         





Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val 

        835                 840                 845             





Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn 

    850                 855                 860                 





Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 

865                 870                 875                 880 





Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 

                885                 890                 895     





Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 

            900                 905                 910         





Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 

        915                 920                 925             





Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val 

    930                 935                 940                 





Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr 

945                 950                 955                 960 





Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 

                965                 970                 975     





Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys 

            980                 985                 990         





Thr Gln Thr Leu His Lys Phe Ile  Leu Leu Phe Ala Val  Phe Asp Glu 

        995                 1000                 1005             





Gly Lys  Ser Trp His Ser Glu  Thr Lys Asn Ser Leu  Met Gln Asp 

    1010                 1015                 1020             





Arg Asp  Ala Ala Ser Ala Arg  Ala Trp Pro Lys Met  His Thr Val 

    1025                 1030                 1035             





Asn Gly  Tyr Val Asn Arg Ser  Leu Pro Gly Leu Ile  Gly Cys His 

    1040                 1045                 1050             





Arg Lys  Ser Val Tyr Trp His  Val Ile Gly Met Gly  Thr Thr Pro 

    1055                 1060                 1065             





Glu Val  His Ser Ile Phe Leu  Glu Gly His Thr Phe  Leu Val Arg 

    1070                 1075                 1080             





Asn His  Arg Gln Ala Ser Leu  Glu Ile Ser Pro Ile  Thr Phe Leu 

    1085                 1090                 1095             





Thr Ala  Gln Thr Leu Leu Met  Asp Leu Gly Gln Phe  Leu Leu Phe 

    1100                 1105                 1110             





Cys His  Ile Ser Ser His Gln  His Asp Gly Met Glu  Ala Tyr Val 

    1115                 1120                 1125             





Lys Val  Asp Ser Cys Pro Glu  Glu Pro Gln Leu Arg  Met Lys Asn 

    1130                 1135                 1140             





Asn Glu  Glu Ala Glu Asp Tyr  Asp Asp Asp Leu Thr  Asp Ser Glu 

    1145                 1150                 1155             





Met Asp  Val Val Arg Phe Asp  Asp Asp Asn Ser Pro  Ser Phe Ile 

    1160                 1165                 1170             





Gln Ile  Arg Ser Val Ala Lys  Lys His Pro Lys Thr  Trp Val His 

    1175                 1180                 1185             





Tyr Ile  Ala Ala Glu Glu Glu  Asp Trp Asp Tyr Ala  Pro Leu Val 

    1190                 1195                 1200             





Leu Ala  Pro Asp Asp Arg Ser  Tyr Lys Ser Gln Tyr  Leu Asn Asn 

    1205                 1210                 1215             





Gly Pro  Gln Arg Ile Gly Arg  Lys Tyr Lys Lys Val  Arg Phe Met 

    1220                 1225                 1230             





Ala Tyr  Thr Asp Glu Thr Phe  Lys Thr Arg Glu Ala  Ile Gln His 

    1235                 1240                 1245             





Glu Ser  Gly Ile Leu Gly Pro  Leu Leu Tyr Gly Glu  Val Gly Asp 

    1250                 1255                 1260             





Thr Leu  Leu Ile Ile Phe Lys  Asn Gln Ala Ser Arg  Pro Tyr Asn 

    1265                 1270                 1275             





Ile Tyr  Pro His Gly Ile Thr  Asp Val Arg Pro Leu  Tyr Ser Arg 

    1280                 1285                 1290             





Arg Leu  Pro Lys Gly Val Lys  His Leu Lys Asp Phe  Pro Ile Leu 

    1295                 1300                 1305             





Pro Gly  Glu Ile Phe Lys Tyr  Lys Trp Thr Val Thr  Val Glu Asp 

    1310                 1315                 1320             





Gly Pro  Thr Lys Ser Asp Pro  Arg Cys Leu Thr Arg  Tyr Tyr Ser 

    1325                 1330                 1335             





Ser Phe  Val Asn Met Glu Arg  Asp Leu Ala Ser Gly  Leu Ile Gly 

    1340                 1345                 1350             





Pro Leu  Leu Ile Cys Tyr Lys  Glu Ser Val Asp Gln  Arg Gly Asn 

    1355                 1360                 1365             





Gln Ile  Met Ser Asp Lys Arg  Asn Val Ile Leu Phe  Ser Val Phe 

    1370                 1375                 1380             





Asp Glu  Asn Arg Ser Trp Tyr  Leu Thr Glu Asn Ile  Gln Arg Phe 

    1385                 1390                 1395             





Leu Pro  Asn Pro Ala Gly Val  Gln Leu Glu Asp Pro  Glu Phe Gln 

    1400                 1405                 1410             





Ala Ser  Asn Ile Met His Ser  Ile Asn Gly Tyr Val  Phe Asp Ser 

    1415                 1420                 1425             





Leu Gln  Leu Ser Val Cys Leu  His Glu Val Ala Tyr  Trp Tyr Ile 

    1430                 1435                 1440             





Leu Ser  Ile Gly Ala Gln Thr  Asp Phe Leu Ser Val  Phe Phe Ser 

    1445                 1450                 1455             





Gly Tyr  Thr Phe Lys His Lys  Met Val Tyr Glu Asp  Thr Leu Thr 

    1460                 1465                 1470             





Leu Phe  Pro Phe Ser Gly Glu  Thr Val Phe Met Ser  Met Glu Asn 

    1475                 1480                 1485             





Pro Gly  Leu Trp Ile Leu Gly  Cys His Asn Ser Asp  Phe Arg Asn 

    1490                 1495                 1500             





Arg Gly  Met Thr Ala Leu Leu  Lys Val Ser Ser Cys  Asp Lys Asn 

    1505                 1510                 1515             





Thr Gly  Asp Tyr Tyr Glu Asp  Ser Tyr Glu Asp Ile  Ser Ala Tyr 

    1520                 1525                 1530             





Leu Leu  Ser Lys Asn Asn Ala  Ile Glu Pro Arg Ser  Phe Ser Gln 

    1535                 1540                 1545             





Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 

    1550                 1555                 1560             





Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 

    1565                 1570                 1575             





Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 

    1580                 1585                 1590             





Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 

    1595                 1600                 1605             





Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 

    1610                 1615                 1620             





Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 

    1625                 1630                 1635             





Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 

    1640                 1645                 1650             





Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 

    1655                 1660                 1665             





Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 

    1670                 1675                 1680             





Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 

    1685                 1690                 1695             





Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 

    1700                 1705                 1710             





Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 

    1715                 1720                 1725             





Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 

    1730                 1735                 1740             





Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 

    1745                 1750                 1755             





Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 

    1760                 1765                 1770             





Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 

    1775                 1780                 1785             





Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 

    1790                 1795                 1800             





Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 

    1805                 1810                 1815             





Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 

    1820                 1825                 1830             





Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 

    1835                 1840                 1845             





Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 

    1850                 1855                 1860             





His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 

    1865                 1870                 1875             





Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 

    1880                 1885                 1890             





Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 

    1895                 1900                 1905             





Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 

    1910                 1915                 1920             





Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 

    1925                 1930                 1935             





Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 

    1940                 1945                 1950             





Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 

    1955                 1960                 1965             





Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 

    1970                 1975                 1980             





Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 

    1985                 1990                 1995             





Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 

    2000                 2005                 2010             





Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 

    2015                 2020                 2025             





Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 

    2030                 2035                 2040             





Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 

    2045                 2050                 2055             





Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 

    2060                 2065                 2070             





Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 

    2075                 2080                 2085             





Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 

    2090                 2095                 2100             





Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 

    2105                 2110                 2115             





Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 

    2120                 2125                 2130             





Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 

    2135                 2140                 2145             





Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 

    2150                 2155                 2160             





Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 

    2165                 2170                 2175             





His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 

    2180                 2185                 2190             





Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 

    2195                 2200                 2205             





Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 

    2210                 2215                 2220             





Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 

    2225                 2230                 2235             





Gln Asp  Leu Tyr 

    2240         





<210>  103

<211>  1959

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN-FVIII-169 mature Protein sequence



<400>  103



Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 

1               5                   10                  15      





Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 

            20                  25                  30          





Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 

        35                  40                  45              





Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 

    50                  55                  60                  





Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 

65                  70                  75                  80  





Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 

                85                  90                  95      





Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 

            100                 105                 110         





Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 

        115                 120                 125             





Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 

    130                 135                 140                 





Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 

145                 150                 155                 160 





His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 

                165                 170                 175     





Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 

            180                 185                 190         





His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 

        195                 200                 205             





His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 

    210                 215                 220                 





Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 

225                 230                 235                 240 





Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 

                245                 250                 255     





Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 

            260                 265                 270         





Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 

        275                 280                 285             





Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 

    290                 295                 300                 





Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 

305                 310                 315                 320 





Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 

                325                 330                 335     





Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 

            340                 345                 350         





Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 

        355                 360                 365             





Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 

    370                 375                 380                 





Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 

385                 390                 395                 400 





Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 

                405                 410                 415     





Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 

            420                 425                 430         





Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 

        435                 440                 445             





Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 

    450                 455                 460                 





Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 

465                 470                 475                 480 





Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 

                485                 490                 495     





His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 

            500                 505                 510         





Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 

        515                 520                 525             





Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 

    530                 535                 540                 





Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 

545                 550                 555                 560 





Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 

                565                 570                 575     





Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 

            580                 585                 590         





Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 

        595                 600                 605             





Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 

    610                 615                 620                 





Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 

625                 630                 635                 640 





Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 

                645                 650                 655     





Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 

            660                 665                 670         





Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 

        675                 680                 685             





Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 

    690                 695                 700                 





Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 

705                 710                 715                 720 





Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 

                725                 730                 735     





Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Ala Pro Gly Thr Ser Glu 

            740                 745                 750         





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 

        755                 760                 765             





Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

    770                 775                 780                 





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 

785                 790                 795                 800 





Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 

                805                 810                 815     





Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

            820                 825                 830         





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

        835                 840                 845             





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

    850                 855                 860                 





Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

865                 870                 875                 880 





Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 

                885                 890                 895     





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            900                 905                 910         





Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

        915                 920                 925             





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

    930                 935                 940                 





Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 

945                 950                 955                 960 





Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

                965                 970                 975     





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

            980                 985                 990         





Glu Pro Ser Glu Gly Ser Ala Pro  Gly Ser Glu Pro Ala  Thr Ser Gly 

        995                 1000                 1005             





Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1010                 1015                 1020             





Pro Gly  Thr Ser Thr Glu Pro  Ser Glu Gly Ser Ala  Pro Ala Ser 

    1025                 1030                 1035             





Ser Pro  Pro Val Leu Lys Arg  His Gln Ala Glu Ile  Thr Arg Thr 

    1040                 1045                 1050             





Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 

    1055                 1060                 1065             





Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 

    1070                 1075                 1080             





Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 

    1085                 1090                 1095             





Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 

    1100                 1105                 1110             





Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 

    1115                 1120                 1125             





Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 

    1130                 1135                 1140             





Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 

    1145                 1150                 1155             





Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 

    1160                 1165                 1170             





Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 

    1175                 1180                 1185             





Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 

    1190                 1195                 1200             





Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 

    1205                 1210                 1215             





Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 

    1220                 1225                 1230             





Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 

    1235                 1240                 1245             





Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 

    1250                 1255                 1260             





Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 

    1265                 1270                 1275             





Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 

    1280                 1285                 1290             





Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 

    1295                 1300                 1305             





Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 

    1310                 1315                 1320             





Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 

    1325                 1330                 1335             





Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 

    1340                 1345                 1350             





His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 

    1355                 1360                 1365             





Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 

    1370                 1375                 1380             





Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 

    1385                 1390                 1395             





Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 

    1400                 1405                 1410             





Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 

    1415                 1420                 1425             





Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 

    1430                 1435                 1440             





Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 

    1445                 1450                 1455             





Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 

    1460                 1465                 1470             





Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 

    1475                 1480                 1485             





Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 

    1490                 1495                 1500             





Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 

    1505                 1510                 1515             





Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 

    1520                 1525                 1530             





Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 

    1535                 1540                 1545             





Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 

    1550                 1555                 1560             





Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 

    1565                 1570                 1575             





Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 

    1580                 1585                 1590             





Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 

    1595                 1600                 1605             





Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 

    1610                 1615                 1620             





Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 

    1625                 1630                 1635             





Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 

    1640                 1645                 1650             





Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 

    1655                 1660                 1665             





His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 

    1670                 1675                 1680             





Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 

    1685                 1690                 1695             





Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 

    1700                 1705                 1710             





Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 

    1715                 1720                 1725             





Gln Asp  Leu Tyr Asp Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala 

    1730                 1735                 1740             





Pro Glu  Leu Leu Gly Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys 

    1745                 1750                 1755             





Pro Lys  Asp Thr Leu Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys 

    1760                 1765                 1770             





Val Val  Val Asp Val Ser His  Glu Asp Pro Glu Val  Lys Phe Asn 

    1775                 1780                 1785             





Trp Tyr  Val Asp Gly Val Glu  Val His Asn Ala Lys  Thr Lys Pro 

    1790                 1795                 1800             





Arg Glu  Glu Gln Tyr Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu 

    1805                 1810                 1815             





Thr Val  Leu His Gln Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys 

    1820                 1825                 1830             





Lys Val  Ser Asn Lys Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile 

    1835                 1840                 1845             





Ser Lys  Ala Lys Gly Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu 

    1850                 1855                 1860             





Pro Pro  Ser Arg Asp Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr 

    1865                 1870                 1875             





Cys Leu  Val Lys Gly Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp 

    1880                 1885                 1890             





Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 

    1895                 1900                 1905             





Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 

    1910                 1915                 1920             





Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 

    1925                 1930                 1935             





Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 

    1940                 1945                 1950             





Ser Leu  Ser Pro Gly Lys 

    1955                 





<210>  104

<211>  1959

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN-FVIII-173 mature Protein



<400>  104



Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 

1               5                   10                  15      





Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 

            20                  25                  30          





Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 

        35                  40                  45              





Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 

    50                  55                  60                  





Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 

65                  70                  75                  80  





Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 

                85                  90                  95      





Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 

            100                 105                 110         





Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 

        115                 120                 125             





Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 

    130                 135                 140                 





Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 

145                 150                 155                 160 





His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 

                165                 170                 175     





Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 

            180                 185                 190         





His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 

        195                 200                 205             





His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 

    210                 215                 220                 





Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 

225                 230                 235                 240 





Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 

                245                 250                 255     





Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 

            260                 265                 270         





Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 

        275                 280                 285             





Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 

    290                 295                 300                 





Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 

305                 310                 315                 320 





Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 

                325                 330                 335     





Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 

            340                 345                 350         





Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 

        355                 360                 365             





Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 

    370                 375                 380                 





Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 

385                 390                 395                 400 





Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 

                405                 410                 415     





Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 

            420                 425                 430         





Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 

        435                 440                 445             





Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 

    450                 455                 460                 





Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 

465                 470                 475                 480 





Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 

                485                 490                 495     





His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 

            500                 505                 510         





Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 

        515                 520                 525             





Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 

    530                 535                 540                 





Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 

545                 550                 555                 560 





Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 

                565                 570                 575     





Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 

            580                 585                 590         





Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 

        595                 600                 605             





Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 

    610                 615                 620                 





Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 

625                 630                 635                 640 





Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 

                645                 650                 655     





Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 

            660                 665                 670         





Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 

        675                 680                 685             





Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 

    690                 695                 700                 





Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 

705                 710                 715                 720 





Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 

                725                 730                 735     





Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Ala Pro Gly Thr Ser Glu 

            740                 745                 750         





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 

        755                 760                 765             





Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

    770                 775                 780                 





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 

785                 790                 795                 800 





Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 

                805                 810                 815     





Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

            820                 825                 830         





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

        835                 840                 845             





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

    850                 855                 860                 





Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

865                 870                 875                 880 





Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 

                885                 890                 895     





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

            900                 905                 910         





Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

        915                 920                 925             





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

    930                 935                 940                 





Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 

945                 950                 955                 960 





Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

                965                 970                 975     





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

            980                 985                 990         





Glu Pro Ser Glu Gly Ser Ala Pro  Gly Ser Glu Pro Ala  Thr Ser Gly 

        995                 1000                 1005             





Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1010                 1015                 1020             





Pro Gly  Thr Ser Thr Glu Pro  Ser Glu Gly Ser Ala  Pro Ala Ser 

    1025                 1030                 1035             





Ser Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 

    1040                 1045                 1050             





Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 

    1055                 1060                 1065             





Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 

    1070                 1075                 1080             





Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 

    1085                 1090                 1095             





Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 

    1100                 1105                 1110             





Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 

    1115                 1120                 1125             





Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 

    1130                 1135                 1140             





Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 

    1145                 1150                 1155             





Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 

    1160                 1165                 1170             





Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 

    1175                 1180                 1185             





Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 

    1190                 1195                 1200             





Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 

    1205                 1210                 1215             





Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 

    1220                 1225                 1230             





Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 

    1235                 1240                 1245             





Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 

    1250                 1255                 1260             





Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 

    1265                 1270                 1275             





Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 

    1280                 1285                 1290             





Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 

    1295                 1300                 1305             





Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 

    1310                 1315                 1320             





Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 

    1325                 1330                 1335             





Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 

    1340                 1345                 1350             





His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 

    1355                 1360                 1365             





Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 

    1370                 1375                 1380             





Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 

    1385                 1390                 1395             





Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 

    1400                 1405                 1410             





Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 

    1415                 1420                 1425             





Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 

    1430                 1435                 1440             





Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 

    1445                 1450                 1455             





Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 

    1460                 1465                 1470             





Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 

    1475                 1480                 1485             





Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 

    1490                 1495                 1500             





Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 

    1505                 1510                 1515             





Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 

    1520                 1525                 1530             





Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 

    1535                 1540                 1545             





Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 

    1550                 1555                 1560             





Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 

    1565                 1570                 1575             





Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 

    1580                 1585                 1590             





Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 

    1595                 1600                 1605             





Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 

    1610                 1615                 1620             





Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 

    1625                 1630                 1635             





Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 

    1640                 1645                 1650             





Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 

    1655                 1660                 1665             





His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 

    1670                 1675                 1680             





Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 

    1685                 1690                 1695             





Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 

    1700                 1705                 1710             





Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 

    1715                 1720                 1725             





Gln Asp  Leu Tyr Asp Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala 

    1730                 1735                 1740             





Pro Glu  Leu Leu Gly Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys 

    1745                 1750                 1755             





Pro Lys  Asp Thr Leu Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys 

    1760                 1765                 1770             





Val Val  Val Asp Val Ser His  Glu Asp Pro Glu Val  Lys Phe Asn 

    1775                 1780                 1785             





Trp Tyr  Val Asp Gly Val Glu  Val His Asn Ala Lys  Thr Lys Pro 

    1790                 1795                 1800             





Arg Glu  Glu Gln Tyr Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu 

    1805                 1810                 1815             





Thr Val  Leu His Gln Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys 

    1820                 1825                 1830             





Lys Val  Ser Asn Lys Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile 

    1835                 1840                 1845             





Ser Lys  Ala Lys Gly Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu 

    1850                 1855                 1860             





Pro Pro  Ser Arg Asp Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr 

    1865                 1870                 1875             





Cys Leu  Val Lys Gly Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp 

    1880                 1885                 1890             





Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 

    1895                 1900                 1905             





Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 

    1910                 1915                 1920             





Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 

    1925                 1930                 1935             





Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 

    1940                 1945                 1950             





Ser Leu  Ser Pro Gly Lys 

    1955                 





<210>  105

<211>  1984

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  FVIII 195 protein sequence



<400>  105



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 

        35                  40                  45              





Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 

    50                  55                  60                  





Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 

65                  70                  75                  80  





Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 

                85                  90                  95      





Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 

            100                 105                 110         





His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 

        115                 120                 125             





Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 

    130                 135                 140                 





Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 

145                 150                 155                 160 





Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 

                165                 170                 175     





Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 

            180                 185                 190         





Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 

        195                 200                 205             





Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 

    210                 215                 220                 





Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 

225                 230                 235                 240 





Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 

                245                 250                 255     





Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 

            260                 265                 270         





Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 

        275                 280                 285             





Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 

    290                 295                 300                 





Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 

305                 310                 315                 320 





Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 

                325                 330                 335     





Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 

            340                 345                 350         





Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 

        355                 360                 365             





Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 

    370                 375                 380                 





Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 

385                 390                 395                 400 





Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 

                405                 410                 415     





Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 

            420                 425                 430         





Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 

        435                 440                 445             





Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 

    450                 455                 460                 





Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 

465                 470                 475                 480 





Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 

                485                 490                 495     





His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 

            500                 505                 510         





Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 

        515                 520                 525             





Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 

    530                 535                 540                 





Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 

545                 550                 555                 560 





Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 

                565                 570                 575     





Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 

            580                 585                 590         





Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 

        595                 600                 605             





Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 

    610                 615                 620                 





Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 

625                 630                 635                 640 





Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 

                645                 650                 655     





Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 

            660                 665                 670         





Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 

        675                 680                 685             





Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 

    690                 695                 700                 





Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 

705                 710                 715                 720 





Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 

                725                 730                 735     





Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 

            740                 745                 750         





Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 

        755                 760                 765             





Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Gly Ala Pro 

    770                 775                 780                 





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 

785                 790                 795                 800 





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

                805                 810                 815     





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

            820                 825                 830         





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 

        835                 840                 845             





Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

    850                 855                 860                 





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

865                 870                 875                 880 





Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 

                885                 890                 895     





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

            900                 905                 910         





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

        915                 920                 925             





Ala Ser Ser Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 

    930                 935                 940                 





Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 

945                 950                 955                 960 





Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 

                965                 970                 975     





Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 

            980                 985                 990         





Leu Arg Asn Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 

        995                 1000                 1005             





Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 

    1010                 1015                 1020             





Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 

    1025                 1030                 1035             





Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln 

    1040                 1045                 1050             





Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 

    1055                 1060                 1065             





Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys 

    1070                 1075                 1080             





Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys Val Gln  His His Met 

    1085                 1090                 1095             





Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 

    1100                 1105                 1110             





Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 

    1115                 1120                 1125             





Pro Leu  Leu Val Cys His Thr  Asn Thr Leu Asn Pro  Ala His Gly 

    1130                 1135                 1140             





Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 

    1145                 1150                 1155             





Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 

    1160                 1165                 1170             





Cys Arg  Gly Ala Pro Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1175                 1180                 1185             





Pro Gly  Ser Glu Pro Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Thr 

    1190                 1195                 1200             





Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro Gly Ser  Glu Pro Ala 

    1205                 1210                 1215             





Thr Ser  Gly Ser Glu Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro 

    1220                 1225                 1230             





Glu Ser  Gly Pro Gly Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala 

    1235                 1240                 1245             





Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Ser 

    1250                 1255                 1260             





Pro Ala  Gly Ser Pro Thr Ser  Thr Glu Glu Gly Ser  Pro Ala Gly 

    1265                 1270                 1275             





Ser Pro  Thr Ser Thr Glu Glu  Gly Ser Pro Ala Gly  Ser Pro Thr 

    1280                 1285                 1290             





Ser Thr  Glu Glu Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1295                 1300                 1305             





Pro Gly  Thr Ser Thr Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ala 

    1310                 1315                 1320             





Ser Ser  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 

    1325                 1330                 1335             





Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 

    1340                 1345                 1350             





Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 

    1355                 1360                 1365             





Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 

    1370                 1375                 1380             





Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 

    1385                 1390                 1395             





Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 

    1400                 1405                 1410             





Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 

    1415                 1420                 1425             





Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 

    1430                 1435                 1440             





Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 

    1445                 1450                 1455             





Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 

    1460                 1465                 1470             





Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 

    1475                 1480                 1485             





Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 

    1490                 1495                 1500             





Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 

    1505                 1510                 1515             





Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 

    1520                 1525                 1530             





Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 

    1535                 1540                 1545             





Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 

    1550                 1555                 1560             





Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 

    1565                 1570                 1575             





Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 

    1580                 1585                 1590             





Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 

    1595                 1600                 1605             





Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 

    1610                 1615                 1620             





Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 

    1625                 1630                 1635             





Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 

    1640                 1645                 1650             





Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 

    1655                 1660                 1665             





Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 

    1670                 1675                 1680             





Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 

    1685                 1690                 1695             





Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 

    1700                 1705                 1710             





Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 

    1715                 1720                 1725             





Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 

    1730                 1735                 1740             





Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Asp 

    1745                 1750                 1755             





Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 

    1760                 1765                 1770             





Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 

    1775                 1780                 1785             





Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 

    1790                 1795                 1800             





Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 

    1805                 1810                 1815             





Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 

    1820                 1825                 1830             





Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 

    1835                 1840                 1845             





Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 

    1850                 1855                 1860             





Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 

    1865                 1870                 1875             





Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 

    1880                 1885                 1890             





Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 

    1895                 1900                 1905             





Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 

    1910                 1915                 1920             





Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 

    1925                 1930                 1935             





Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 

    1940                 1945                 1950             





Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 

    1955                 1960                 1965             





Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 

    1970                 1975                 1980             





Lys 

    





<210>  106

<211>  2134

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  FVIII 196 protein sequence



<400>  106



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Gly Ala Pro 

        35                  40                  45              





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 

    50                  55                  60                  





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

65                  70                  75                  80  





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

                85                  90                  95      





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 

            100                 105                 110         





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

        115                 120                 125             





Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 

    130                 135                 140                 





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

145                 150                 155                 160 





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

                165                 170                 175     





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

            180                 185                 190         





Ala Ser Ser Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro 

        195                 200                 205             





Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr 

    210                 215                 220                 





Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu 

225                 230                 235                 240 





Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr 

                245                 250                 255     





Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val 

            260                 265                 270         





Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser 

        275                 280                 285             





Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 

    290                 295                 300                 





Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 

305                 310                 315                 320 





Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 

                325                 330                 335     





Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 

            340                 345                 350         





Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 

        355                 360                 365             





Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 

    370                 375                 380                 





Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 

385                 390                 395                 400 





His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 

                405                 410                 415     





Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 

            420                 425                 430         





Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 

        435                 440                 445             





Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 

    450                 455                 460                 





Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 

465                 470                 475                 480 





Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 

                485                 490                 495     





Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 

            500                 505                 510         





Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 

        515                 520                 525             





Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 

    530                 535                 540                 





Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 

545                 550                 555                 560 





Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 

                565                 570                 575     





Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 

            580                 585                 590         





Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 

        595                 600                 605             





Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 

    610                 615                 620                 





Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 

625                 630                 635                 640 





Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 

                645                 650                 655     





Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 

            660                 665                 670         





Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 

        675                 680                 685             





Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 

    690                 695                 700                 





Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 

705                 710                 715                 720 





Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 

                725                 730                 735     





Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 

            740                 745                 750         





Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 

        755                 760                 765             





Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 

    770                 775                 780                 





Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 

785                 790                 795                 800 





His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 

                805                 810                 815     





Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 

            820                 825                 830         





Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 

        835                 840                 845             





Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 

    850                 855                 860                 





Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 

865                 870                 875                 880 





Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 

                885                 890                 895     





Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 

            900                 905                 910         





Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 

        915                 920                 925             





Thr Leu Gln Gly Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser 

    930                 935                 940                 





Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala 

945                 950                 955                 960 





Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr 

                965                 970                 975     





Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr 

            980                 985                 990         





Gly Pro Gly Thr Pro Gly Ser Gly  Thr Ala Ser Ser Ser  Pro Gly Ala 

        995                 1000                 1005             





Ser Pro  Gly Thr Ser Ser Thr  Gly Ser Pro Gly Ala  Ser Pro Gly 

    1010                 1015                 1020             





Thr Ser  Ser Thr Gly Ser Pro  Gly Ala Ser Pro Gly  Thr Ser Ser 

    1025                 1030                 1035             





Thr Gly  Ser Pro Gly Ser Ser  Thr Pro Ser Gly Ala  Thr Gly Ser 

    1040                 1045                 1050             





Pro Gly  Ser Ser Thr Pro Ser  Gly Ala Thr Gly Ser  Pro Gly Ala 

    1055                 1060                 1065             





Ser Pro  Gly Thr Ser Ser Thr  Gly Ser Pro Ala Ser  Ser Ser Asp 

    1070                 1075                 1080             





Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile Ser Val  Glu Met Lys 

    1085                 1090                 1095             





Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp Glu Asn  Gln Ser Pro 

    1100                 1105                 1110             





Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr Phe Ile  Ala Ala Val 

    1115                 1120                 1125             





Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser Ser Pro  His Val Leu 

    1130                 1135                 1140             





Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 

    1145                 1150                 1155             





Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 

    1160                 1165                 1170             





Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 

    1175                 1180                 1185             





Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln 

    1190                 1195                 1200             





Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 

    1205                 1210                 1215             





Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys 

    1220                 1225                 1230             





Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys Val Gln  His His Met 

    1235                 1240                 1245             





Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 

    1250                 1255                 1260             





Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 

    1265                 1270                 1275             





Pro Leu  Leu Val Cys His Thr  Asn Thr Leu Asn Pro  Ala His Gly 

    1280                 1285                 1290             





Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 

    1295                 1300                 1305             





Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 

    1310                 1315                 1320             





Cys Arg  Gly Ala Pro Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1325                 1330                 1335             





Pro Gly  Ser Glu Pro Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Thr 

    1340                 1345                 1350             





Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro Gly Ser  Glu Pro Ala 

    1355                 1360                 1365             





Thr Ser  Gly Ser Glu Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro 

    1370                 1375                 1380             





Glu Ser  Gly Pro Gly Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala 

    1385                 1390                 1395             





Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Ser 

    1400                 1405                 1410             





Pro Ala  Gly Ser Pro Thr Ser  Thr Glu Glu Gly Ser  Pro Ala Gly 

    1415                 1420                 1425             





Ser Pro  Thr Ser Thr Glu Glu  Gly Ser Pro Ala Gly  Ser Pro Thr 

    1430                 1435                 1440             





Ser Thr  Glu Glu Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1445                 1450                 1455             





Pro Gly  Thr Ser Thr Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ala 

    1460                 1465                 1470             





Ser Ser  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 

    1475                 1480                 1485             





Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 

    1490                 1495                 1500             





Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 

    1505                 1510                 1515             





Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 

    1520                 1525                 1530             





Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 

    1535                 1540                 1545             





Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 

    1550                 1555                 1560             





Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 

    1565                 1570                 1575             





Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 

    1580                 1585                 1590             





Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 

    1595                 1600                 1605             





Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 

    1610                 1615                 1620             





Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 

    1625                 1630                 1635             





Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 

    1640                 1645                 1650             





Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 

    1655                 1660                 1665             





Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 

    1670                 1675                 1680             





Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 

    1685                 1690                 1695             





Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 

    1700                 1705                 1710             





Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 

    1715                 1720                 1725             





Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 

    1730                 1735                 1740             





Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 

    1745                 1750                 1755             





Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 

    1760                 1765                 1770             





Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 

    1775                 1780                 1785             





Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 

    1790                 1795                 1800             





Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 

    1805                 1810                 1815             





Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 

    1820                 1825                 1830             





Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 

    1835                 1840                 1845             





Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 

    1850                 1855                 1860             





Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 

    1865                 1870                 1875             





Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 

    1880                 1885                 1890             





Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Asp 

    1895                 1900                 1905             





Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 

    1910                 1915                 1920             





Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 

    1925                 1930                 1935             





Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 

    1940                 1945                 1950             





Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 

    1955                 1960                 1965             





Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 

    1970                 1975                 1980             





Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 

    1985                 1990                 1995             





Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 

    2000                 2005                 2010             





Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 

    2015                 2020                 2025             





Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 

    2030                 2035                 2040             





Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 

    2045                 2050                 2055             





Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 

    2060                 2065                 2070             





Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 

    2075                 2080                 2085             





Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 

    2090                 2095                 2100             





Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 

    2105                 2110                 2115             





Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 

    2120                 2125                 2130             





Lys 

    





<210>  107

<211>  1984

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  FVIII 199 protein sequence



<400>  107



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 

        35                  40                  45              





Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 

    50                  55                  60                  





Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 

65                  70                  75                  80  





Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 

                85                  90                  95      





Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 

            100                 105                 110         





His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 

        115                 120                 125             





Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 

    130                 135                 140                 





Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 

145                 150                 155                 160 





Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 

                165                 170                 175     





Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 

            180                 185                 190         





Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 

        195                 200                 205             





Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 

    210                 215                 220                 





Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 

225                 230                 235                 240 





Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 

                245                 250                 255     





Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 

            260                 265                 270         





Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 

        275                 280                 285             





Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 

    290                 295                 300                 





Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 

305                 310                 315                 320 





Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 

                325                 330                 335     





Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 

            340                 345                 350         





Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 

        355                 360                 365             





Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 

    370                 375                 380                 





Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 

385                 390                 395                 400 





Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 

                405                 410                 415     





Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 

            420                 425                 430         





Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 

        435                 440                 445             





Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 

    450                 455                 460                 





Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 

465                 470                 475                 480 





Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 

                485                 490                 495     





His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 

            500                 505                 510         





Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 

        515                 520                 525             





Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 

    530                 535                 540                 





Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 

545                 550                 555                 560 





Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 

                565                 570                 575     





Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 

            580                 585                 590         





Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 

        595                 600                 605             





Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 

    610                 615                 620                 





Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 

625                 630                 635                 640 





Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 

                645                 650                 655     





Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 

            660                 665                 670         





Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 

        675                 680                 685             





Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 

    690                 695                 700                 





Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 

705                 710                 715                 720 





Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 

                725                 730                 735     





Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 

            740                 745                 750         





Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 

        755                 760                 765             





Lys Arg His Gln Ala Glu Ile Thr Arg Thr Thr Leu Gln Gly Ala Pro 

    770                 775                 780                 





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 

785                 790                 795                 800 





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

                805                 810                 815     





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

            820                 825                 830         





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 

        835                 840                 845             





Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

    850                 855                 860                 





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

865                 870                 875                 880 





Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 

                885                 890                 895     





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

            900                 905                 910         





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

        915                 920                 925             





Ala Ser Ser Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 

    930                 935                 940                 





Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 

945                 950                 955                 960 





Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 

                965                 970                 975     





Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 

            980                 985                 990         





Leu Arg Asn Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 

        995                 1000                 1005             





Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 

    1010                 1015                 1020             





Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 

    1025                 1030                 1035             





Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln 

    1040                 1045                 1050             





Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 

    1055                 1060                 1065             





Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys 

    1070                 1075                 1080             





Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys Val Gln  His His Met 

    1085                 1090                 1095             





Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 

    1100                 1105                 1110             





Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 

    1115                 1120                 1125             





Pro Leu  Leu Val Cys His Thr  Asn Thr Leu Asn Pro  Ala His Gly 

    1130                 1135                 1140             





Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 

    1145                 1150                 1155             





Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 

    1160                 1165                 1170             





Cys Arg  Gly Ala Pro Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1175                 1180                 1185             





Pro Gly  Ser Glu Pro Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Thr 

    1190                 1195                 1200             





Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro Gly Ser  Glu Pro Ala 

    1205                 1210                 1215             





Thr Ser  Gly Ser Glu Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro 

    1220                 1225                 1230             





Glu Ser  Gly Pro Gly Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala 

    1235                 1240                 1245             





Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Ser 

    1250                 1255                 1260             





Pro Ala  Gly Ser Pro Thr Ser  Thr Glu Glu Gly Ser  Pro Ala Gly 

    1265                 1270                 1275             





Ser Pro  Thr Ser Thr Glu Glu  Gly Ser Pro Ala Gly  Ser Pro Thr 

    1280                 1285                 1290             





Ser Thr  Glu Glu Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1295                 1300                 1305             





Pro Gly  Thr Ser Thr Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ala 

    1310                 1315                 1320             





Ser Ser  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 

    1325                 1330                 1335             





Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 

    1340                 1345                 1350             





Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 

    1355                 1360                 1365             





Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 

    1370                 1375                 1380             





Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 

    1385                 1390                 1395             





Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 

    1400                 1405                 1410             





Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 

    1415                 1420                 1425             





Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 

    1430                 1435                 1440             





Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 

    1445                 1450                 1455             





Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 

    1460                 1465                 1470             





Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 

    1475                 1480                 1485             





Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 

    1490                 1495                 1500             





Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 

    1505                 1510                 1515             





Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 

    1520                 1525                 1530             





Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 

    1535                 1540                 1545             





Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 

    1550                 1555                 1560             





Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 

    1565                 1570                 1575             





Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 

    1580                 1585                 1590             





Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 

    1595                 1600                 1605             





Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 

    1610                 1615                 1620             





Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 

    1625                 1630                 1635             





Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 

    1640                 1645                 1650             





Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 

    1655                 1660                 1665             





Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 

    1670                 1675                 1680             





Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 

    1685                 1690                 1695             





Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 

    1700                 1705                 1710             





Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 

    1715                 1720                 1725             





Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 

    1730                 1735                 1740             





Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Asp 

    1745                 1750                 1755             





Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 

    1760                 1765                 1770             





Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 

    1775                 1780                 1785             





Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 

    1790                 1795                 1800             





Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 

    1805                 1810                 1815             





Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 

    1820                 1825                 1830             





Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 

    1835                 1840                 1845             





Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 

    1850                 1855                 1860             





Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 

    1865                 1870                 1875             





Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 

    1880                 1885                 1890             





Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 

    1895                 1900                 1905             





Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 

    1910                 1915                 1920             





Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 

    1925                 1930                 1935             





Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 

    1940                 1945                 1950             





Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 

    1955                 1960                 1965             





Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 

    1970                 1975                 1980             





Lys 

    





<210>  108

<211>  2134

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  FVIII 201 protein sequence



<400>  108



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Gly Ala Pro 

        35                  40                  45              





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 

    50                  55                  60                  





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

65                  70                  75                  80  





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

                85                  90                  95      





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 

            100                 105                 110         





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

        115                 120                 125             





Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 

    130                 135                 140                 





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

145                 150                 155                 160 





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

                165                 170                 175     





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

            180                 185                 190         





Ala Ser Ser Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro 

        195                 200                 205             





Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr 

    210                 215                 220                 





Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu 

225                 230                 235                 240 





Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr 

                245                 250                 255     





Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val 

            260                 265                 270         





Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser 

        275                 280                 285             





Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 

    290                 295                 300                 





Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 

305                 310                 315                 320 





Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 

                325                 330                 335     





Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 

            340                 345                 350         





Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 

        355                 360                 365             





Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 

    370                 375                 380                 





Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 

385                 390                 395                 400 





His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 

                405                 410                 415     





Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 

            420                 425                 430         





Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 

        435                 440                 445             





Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 

    450                 455                 460                 





Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 

465                 470                 475                 480 





Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 

                485                 490                 495     





Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 

            500                 505                 510         





Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 

        515                 520                 525             





Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 

    530                 535                 540                 





Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 

545                 550                 555                 560 





Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 

                565                 570                 575     





Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 

            580                 585                 590         





Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 

        595                 600                 605             





Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 

    610                 615                 620                 





Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 

625                 630                 635                 640 





Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 

                645                 650                 655     





Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 

            660                 665                 670         





Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 

        675                 680                 685             





Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 

    690                 695                 700                 





Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 

705                 710                 715                 720 





Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 

                725                 730                 735     





Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 

            740                 745                 750         





Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 

        755                 760                 765             





Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 

    770                 775                 780                 





Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 

785                 790                 795                 800 





His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 

                805                 810                 815     





Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 

            820                 825                 830         





Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 

        835                 840                 845             





Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 

    850                 855                 860                 





Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 

865                 870                 875                 880 





Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 

                885                 890                 895     





Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 

            900                 905                 910         





Gln Asn Pro Pro Val Leu Lys Arg His Gln Ala Glu Ile Thr Arg Thr 

        915                 920                 925             





Thr Leu Gln Gly Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser 

    930                 935                 940                 





Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala 

945                 950                 955                 960 





Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr 

                965                 970                 975     





Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr 

            980                 985                 990         





Gly Pro Gly Thr Pro Gly Ser Gly  Thr Ala Ser Ser Ser  Pro Gly Ala 

        995                 1000                 1005             





Ser Pro  Gly Thr Ser Ser Thr  Gly Ser Pro Gly Ala  Ser Pro Gly 

    1010                 1015                 1020             





Thr Ser  Ser Thr Gly Ser Pro  Gly Ala Ser Pro Gly  Thr Ser Ser 

    1025                 1030                 1035             





Thr Gly  Ser Pro Gly Ser Ser  Thr Pro Ser Gly Ala  Thr Gly Ser 

    1040                 1045                 1050             





Pro Gly  Ser Ser Thr Pro Ser  Gly Ala Thr Gly Ser  Pro Gly Ala 

    1055                 1060                 1065             





Ser Pro  Gly Thr Ser Ser Thr  Gly Ser Pro Ala Ser  Ser Ser Asp 

    1070                 1075                 1080             





Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile Ser Val  Glu Met Lys 

    1085                 1090                 1095             





Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp Glu Asn  Gln Ser Pro 

    1100                 1105                 1110             





Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr Phe Ile  Ala Ala Val 

    1115                 1120                 1125             





Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser Ser Pro  His Val Leu 

    1130                 1135                 1140             





Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 

    1145                 1150                 1155             





Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 

    1160                 1165                 1170             





Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 

    1175                 1180                 1185             





Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln 

    1190                 1195                 1200             





Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 

    1205                 1210                 1215             





Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys 

    1220                 1225                 1230             





Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys Val Gln  His His Met 

    1235                 1240                 1245             





Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 

    1250                 1255                 1260             





Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 

    1265                 1270                 1275             





Pro Leu  Leu Val Cys His Thr  Asn Thr Leu Asn Pro  Ala His Gly 

    1280                 1285                 1290             





Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 

    1295                 1300                 1305             





Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 

    1310                 1315                 1320             





Cys Arg  Gly Ala Pro Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1325                 1330                 1335             





Pro Gly  Ser Glu Pro Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Thr 

    1340                 1345                 1350             





Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro Gly Ser  Glu Pro Ala 

    1355                 1360                 1365             





Thr Ser  Gly Ser Glu Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro 

    1370                 1375                 1380             





Glu Ser  Gly Pro Gly Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala 

    1385                 1390                 1395             





Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Ser 

    1400                 1405                 1410             





Pro Ala  Gly Ser Pro Thr Ser  Thr Glu Glu Gly Ser  Pro Ala Gly 

    1415                 1420                 1425             





Ser Pro  Thr Ser Thr Glu Glu  Gly Ser Pro Ala Gly  Ser Pro Thr 

    1430                 1435                 1440             





Ser Thr  Glu Glu Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 

    1445                 1450                 1455             





Pro Gly  Thr Ser Thr Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ala 

    1460                 1465                 1470             





Ser Ser  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 

    1475                 1480                 1485             





Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 

    1490                 1495                 1500             





Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 

    1505                 1510                 1515             





Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 

    1520                 1525                 1530             





Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 

    1535                 1540                 1545             





Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 

    1550                 1555                 1560             





Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 

    1565                 1570                 1575             





Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 

    1580                 1585                 1590             





Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 

    1595                 1600                 1605             





Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 

    1610                 1615                 1620             





Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 

    1625                 1630                 1635             





Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 

    1640                 1645                 1650             





Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 

    1655                 1660                 1665             





Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 

    1670                 1675                 1680             





Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 

    1685                 1690                 1695             





Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 

    1700                 1705                 1710             





Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 

    1715                 1720                 1725             





Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 

    1730                 1735                 1740             





Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 

    1745                 1750                 1755             





Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 

    1760                 1765                 1770             





Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 

    1775                 1780                 1785             





Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 

    1790                 1795                 1800             





Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 

    1805                 1810                 1815             





Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 

    1820                 1825                 1830             





Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 

    1835                 1840                 1845             





Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 

    1850                 1855                 1860             





Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 

    1865                 1870                 1875             





Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 

    1880                 1885                 1890             





Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Asp 

    1895                 1900                 1905             





Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 

    1910                 1915                 1920             





Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 

    1925                 1930                 1935             





Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 

    1940                 1945                 1950             





Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 

    1955                 1960                 1965             





Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 

    1970                 1975                 1980             





Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 

    1985                 1990                 1995             





Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 

    2000                 2005                 2010             





Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 

    2015                 2020                 2025             





Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 

    2030                 2035                 2040             





Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 

    2045                 2050                 2055             





Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 

    2060                 2065                 2070             





Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 

    2075                 2080                 2085             





Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 

    2090                 2095                 2100             





Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 

    2105                 2110                 2115             





Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 

    2120                 2125                 2130             





Lys 

    





<210>  109

<211>  2128

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  FVIII 203 protein sequence



<400>  109



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 

        35                  40                  45              





Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 

    50                  55                  60                  





Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 

65                  70                  75                  80  





Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 

                85                  90                  95      





Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 

            100                 105                 110         





His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 

        115                 120                 125             





Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 

    130                 135                 140                 





Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 

145                 150                 155                 160 





Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 

                165                 170                 175     





Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 

            180                 185                 190         





Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 

        195                 200                 205             





Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 

    210                 215                 220                 





Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 

225                 230                 235                 240 





Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 

                245                 250                 255     





Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 

            260                 265                 270         





Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 

        275                 280                 285             





Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 

    290                 295                 300                 





Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 

305                 310                 315                 320 





Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 

                325                 330                 335     





Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 

            340                 345                 350         





Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 

        355                 360                 365             





Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 

    370                 375                 380                 





Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 

385                 390                 395                 400 





Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 

                405                 410                 415     





Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 

            420                 425                 430         





Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 

        435                 440                 445             





Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 

    450                 455                 460                 





Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 

465                 470                 475                 480 





Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 

                485                 490                 495     





His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 

            500                 505                 510         





Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 

        515                 520                 525             





Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 

    530                 535                 540                 





Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 

545                 550                 555                 560 





Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 

                565                 570                 575     





Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 

            580                 585                 590         





Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 

        595                 600                 605             





Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 

    610                 615                 620                 





Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 

625                 630                 635                 640 





Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 

                645                 650                 655     





Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 

            660                 665                 670         





Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 

        675                 680                 685             





Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 

    690                 695                 700                 





Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 

705                 710                 715                 720 





Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 

                725                 730                 735     





Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 

            740                 745                 750         





Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Ala Pro Gly 

        755                 760                 765             





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

    770                 775                 780                 





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

785                 790                 795                 800 





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

                805                 810                 815     





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 

            820                 825                 830         





Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

        835                 840                 845             





Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

    850                 855                 860                 





Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 

865                 870                 875                 880 





Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

                885                 890                 895     





Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 

            900                 905                 910         





Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 

        915                 920                 925             





Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

    930                 935                 940                 





Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

945                 950                 955                 960 





Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 

                965                 970                 975     





Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

            980                 985                 990         





Thr Glu Glu Gly Thr Ser Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Gly 

        995                 1000                 1005             





Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Ser Glu Pro 

    1010                 1015                 1020             





Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr 

    1025                 1030                 1035             





Pro Glu  Ser Gly Pro Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser 

    1040                 1045                 1050             





Ala Pro  Ala Ser Ser Pro Pro  Val Leu Lys Arg His  Gln Ala Glu 

    1055                 1060                 1065             





Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 

    1070                 1075                 1080             





Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 

    1085                 1090                 1095             





Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 

    1100                 1105                 1110             





Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 

    1115                 1120                 1125             





Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 

    1130                 1135                 1140             





Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 

    1145                 1150                 1155             





Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 

    1160                 1165                 1170             





His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 

    1175                 1180                 1185             





Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 

    1190                 1195                 1200             





Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 

    1205                 1210                 1215             





Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 

    1220                 1225                 1230             





Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 

    1235                 1240                 1245             





Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 

    1250                 1255                 1260             





Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 

    1265                 1270                 1275             





Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 

    1280                 1285                 1290             





Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 

    1295                 1300                 1305             





Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Gly  Ala Pro Thr 

    1310                 1315                 1320             





Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro Gly Ser  Glu Pro Ala 

    1325                 1330                 1335             





Thr Ser  Gly Ser Glu Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro 

    1340                 1345                 1350             





Glu Ser  Gly Pro Gly Ser Glu  Pro Ala Thr Ser Gly  Ser Glu Thr 

    1355                 1360                 1365             





Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Thr 

    1370                 1375                 1380             





Ser Thr  Glu Pro Ser Glu Gly  Ser Ala Pro Gly Thr  Ser Glu Ser 

    1385                 1390                 1395             





Ala Thr  Pro Glu Ser Gly Pro  Gly Ser Pro Ala Gly  Ser Pro Thr 

    1400                 1405                 1410             





Ser Thr  Glu Glu Gly Ser Pro  Ala Gly Ser Pro Thr  Ser Thr Glu 

    1415                 1420                 1425             





Glu Gly  Ser Pro Ala Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Thr 

    1430                 1435                 1440             





Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro Gly Thr  Ser Thr Glu 

    1445                 1450                 1455             





Pro Ser  Glu Gly Ser Ala Pro  Gly Ala Ser Ser Ala  Pro Cys Asn 

    1460                 1465                 1470             





Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 

    1475                 1480                 1485             





Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 

    1490                 1495                 1500             





Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 

    1505                 1510                 1515             





Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 

    1520                 1525                 1530             





Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 

    1535                 1540                 1545             





Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 

    1550                 1555                 1560             





Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 

    1565                 1570                 1575             





Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 

    1580                 1585                 1590             





Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 

    1595                 1600                 1605             





Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 

    1610                 1615                 1620             





Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 

    1625                 1630                 1635             





Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 

    1640                 1645                 1650             





Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 

    1655                 1660                 1665             





Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 

    1670                 1675                 1680             





Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 

    1685                 1690                 1695             





Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 

    1700                 1705                 1710             





Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 

    1715                 1720                 1725             





Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 

    1730                 1735                 1740             





Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 

    1745                 1750                 1755             





Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 

    1760                 1765                 1770             





Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 

    1775                 1780                 1785             





Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 

    1790                 1795                 1800             





Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 

    1805                 1810                 1815             





Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 

    1820                 1825                 1830             





Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 

    1835                 1840                 1845             





Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 

    1850                 1855                 1860             





Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 

    1865                 1870                 1875             





Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 

    1880                 1885                 1890             





Gly Cys  Glu Ala Gln Asp Leu  Tyr Asp Lys Thr His  Thr Cys Pro 

    1895                 1900                 1905             





Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu 

    1910                 1915                 1920             





Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro 

    1925                 1930                 1935             





Glu Val  Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 

    1940                 1945                 1950             





Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 

    1955                 1960                 1965             





Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 

    1970                 1975                 1980             





Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 

    1985                 1990                 1995             





Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 

    2000                 2005                 2010             





Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 

    2015                 2020                 2025             





Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 

    2030                 2035                 2040             





Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 

    2045                 2050                 2055             





Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 

    2060                 2065                 2070             





Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 

    2075                 2080                 2085             





Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 

    2090                 2095                 2100             





Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 

    2105                 2110                 2115             





Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 

    2120                 2125             





<210>  110

<211>  2128

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  FVIII 204 protein sequence



<400>  110



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 

        35                  40                  45              





Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 

    50                  55                  60                  





Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 

65                  70                  75                  80  





Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 

                85                  90                  95      





Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 

            100                 105                 110         





His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 

        115                 120                 125             





Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 

    130                 135                 140                 





Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 

145                 150                 155                 160 





Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 

                165                 170                 175     





Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 

            180                 185                 190         





Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 

        195                 200                 205             





Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 

    210                 215                 220                 





Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 

225                 230                 235                 240 





Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 

                245                 250                 255     





Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 

            260                 265                 270         





Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 

        275                 280                 285             





Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 

    290                 295                 300                 





Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 

305                 310                 315                 320 





Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 

                325                 330                 335     





Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 

            340                 345                 350         





Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 

        355                 360                 365             





Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 

    370                 375                 380                 





Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 

385                 390                 395                 400 





Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 

                405                 410                 415     





Leu Val Leu Ala Pro Asp Gly Ala Pro Thr Ser Thr Glu Pro Ser Glu 

            420                 425                 430         





Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

        435                 440                 445             





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

    450                 455                 460                 





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

465                 470                 475                 480 





Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

                485                 490                 495     





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

            500                 505                 510         





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu 

        515                 520                 525             





Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

    530                 535                 540                 





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 

545                 550                 555                 560 





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ala Ser Ser Asp Arg Ser Tyr 

                565                 570                 575     





Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 

            580                 585                 590         





Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 

        595                 600                 605             





Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 

    610                 615                 620                 





Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 

625                 630                 635                 640 





Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 

                645                 650                 655     





Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 

            660                 665                 670         





Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 

        675                 680                 685             





Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 

    690                 695                 700                 





Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 

705                 710                 715                 720 





Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 

                725                 730                 735     





Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 

            740                 745                 750         





Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 

        755                 760                 765             





Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 

    770                 775                 780                 





Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 

785                 790                 795                 800 





His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 

                805                 810                 815     





Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 

            820                 825                 830         





Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 

        835                 840                 845             





Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 

    850                 855                 860                 





Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 

865                 870                 875                 880 





Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 

                885                 890                 895     





Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 

            900                 905                 910         





Gln Asn Gly Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

        915                 920                 925             





Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 

    930                 935                 940                 





Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 

945                 950                 955                 960 





Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

                965                 970                 975     





Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 

            980                 985                 990         





Ala Gly Ser Pro Thr Ser Thr Glu  Glu Gly Thr Ser Glu  Ser Ala Thr 

        995                 1000                 1005             





Pro Glu  Ser Gly Pro Gly Ser  Glu Pro Ala Thr Ser  Gly Ser Glu 

    1010                 1015                 1020             





Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 

    1025                 1030                 1035             





Ser Pro  Ala Gly Ser Pro Thr  Ser Thr Glu Glu Gly  Ser Pro Ala 

    1040                 1045                 1050             





Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Thr Ser Thr  Glu Pro Ser 

    1055                 1060                 1065             





Glu Gly  Ser Ala Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 

    1070                 1075                 1080             





Gly Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 

    1085                 1090                 1095             





Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly Pro Gly  Ser Glu Pro 

    1100                 1105                 1110             





Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Ser Glu Pro  Ala Thr Ser 

    1115                 1120                 1125             





Gly Ser  Glu Thr Pro Gly Ser  Pro Ala Gly Ser Pro  Thr Ser Thr 

    1130                 1135                 1140             





Glu Glu  Gly Thr Ser Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Gly 

    1145                 1150                 1155             





Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Ser Glu Pro 

    1160                 1165                 1170             





Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr 

    1175                 1180                 1185             





Pro Glu  Ser Gly Pro Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser 

    1190                 1195                 1200             





Ala Pro  Ala Ser Ser Pro Pro  Val Leu Lys Arg His  Gln Ala Glu 

    1205                 1210                 1215             





Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 

    1220                 1225                 1230             





Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 

    1235                 1240                 1245             





Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 

    1250                 1255                 1260             





Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 

    1265                 1270                 1275             





Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 

    1280                 1285                 1290             





Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 

    1295                 1300                 1305             





Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 

    1310                 1315                 1320             





His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 

    1325                 1330                 1335             





Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 

    1340                 1345                 1350             





Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 

    1355                 1360                 1365             





Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 

    1370                 1375                 1380             





Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 

    1385                 1390                 1395             





Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 

    1400                 1405                 1410             





Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 

    1415                 1420                 1425             





Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 

    1430                 1435                 1440             





Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 

    1445                 1450                 1455             





Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 

    1460                 1465                 1470             





Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 

    1475                 1480                 1485             





Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 

    1490                 1495                 1500             





Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 

    1505                 1510                 1515             





Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 

    1520                 1525                 1530             





Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 

    1535                 1540                 1545             





Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 

    1550                 1555                 1560             





Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 

    1565                 1570                 1575             





Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 

    1580                 1585                 1590             





Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 

    1595                 1600                 1605             





Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 

    1610                 1615                 1620             





Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 

    1625                 1630                 1635             





Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 

    1640                 1645                 1650             





Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 

    1655                 1660                 1665             





Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 

    1670                 1675                 1680             





Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 

    1685                 1690                 1695             





Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 

    1700                 1705                 1710             





Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 

    1715                 1720                 1725             





Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 

    1730                 1735                 1740             





Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 

    1745                 1750                 1755             





Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 

    1760                 1765                 1770             





Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 

    1775                 1780                 1785             





Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 

    1790                 1795                 1800             





Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 

    1805                 1810                 1815             





Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 

    1820                 1825                 1830             





Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 

    1835                 1840                 1845             





Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 

    1850                 1855                 1860             





Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 

    1865                 1870                 1875             





Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 

    1880                 1885                 1890             





Gly Cys  Glu Ala Gln Asp Leu  Tyr Asp Lys Thr His  Thr Cys Pro 

    1895                 1900                 1905             





Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu 

    1910                 1915                 1920             





Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro 

    1925                 1930                 1935             





Glu Val  Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 

    1940                 1945                 1950             





Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 

    1955                 1960                 1965             





Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 

    1970                 1975                 1980             





Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 

    1985                 1990                 1995             





Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 

    2000                 2005                 2010             





Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 

    2015                 2020                 2025             





Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 

    2030                 2035                 2040             





Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 

    2045                 2050                 2055             





Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 

    2060                 2065                 2070             





Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 

    2075                 2080                 2085             





Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 

    2090                 2095                 2100             





Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 

    2105                 2110                 2115             





Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 

    2120                 2125             





<210>  111

<211>  2128

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  FVIII 205 protein sequence



<400>  111



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu 

        35                  40                  45              





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

    50                  55                  60                  





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

65                  70                  75                  80  





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

                85                  90                  95      





Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

            100                 105                 110         





Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 

        115                 120                 125             





Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 

    130                 135                 140                 





Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

145                 150                 155                 160 





Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 

                165                 170                 175     





Ser Pro Thr Ser Thr Glu Glu Gly Ala Ser Ser Ser Asp Leu Gly Glu 

            180                 185                 190         





Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro 

        195                 200                 205             





Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr 

    210                 215                 220                 





Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu 

225                 230                 235                 240 





Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr 

                245                 250                 255     





Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val 

            260                 265                 270         





Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser 

        275                 280                 285             





Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 

    290                 295                 300                 





Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 

305                 310                 315                 320 





Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 

                325                 330                 335     





Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 

            340                 345                 350         





Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 

        355                 360                 365             





Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 

    370                 375                 380                 





Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 

385                 390                 395                 400 





His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 

                405                 410                 415     





Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 

            420                 425                 430         





Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 

        435                 440                 445             





Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 

    450                 455                 460                 





Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 

465                 470                 475                 480 





Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 

                485                 490                 495     





Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 

            500                 505                 510         





Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 

        515                 520                 525             





Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 

    530                 535                 540                 





Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 

545                 550                 555                 560 





Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 

                565                 570                 575     





Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 

            580                 585                 590         





Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 

        595                 600                 605             





Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 

    610                 615                 620                 





Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 

625                 630                 635                 640 





Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 

                645                 650                 655     





Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 

            660                 665                 670         





Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 

        675                 680                 685             





Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 

    690                 695                 700                 





Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 

705                 710                 715                 720 





Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 

                725                 730                 735     





Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 

            740                 745                 750         





Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 

        755                 760                 765             





Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 

    770                 775                 780                 





Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 

785                 790                 795                 800 





His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 

                805                 810                 815     





Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 

            820                 825                 830         





Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 

        835                 840                 845             





Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 

    850                 855                 860                 





Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 

865                 870                 875                 880 





Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 

                885                 890                 895     





Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 

            900                 905                 910         





Gln Asn Gly Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

        915                 920                 925             





Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 

    930                 935                 940                 





Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 

945                 950                 955                 960 





Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

                965                 970                 975     





Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 

            980                 985                 990         





Ala Gly Ser Pro Thr Ser Thr Glu  Glu Gly Thr Ser Glu  Ser Ala Thr 

        995                 1000                 1005             





Pro Glu  Ser Gly Pro Gly Ser  Glu Pro Ala Thr Ser  Gly Ser Glu 

    1010                 1015                 1020             





Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 

    1025                 1030                 1035             





Ser Pro  Ala Gly Ser Pro Thr  Ser Thr Glu Glu Gly  Ser Pro Ala 

    1040                 1045                 1050             





Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Thr Ser Thr  Glu Pro Ser 

    1055                 1060                 1065             





Glu Gly  Ser Ala Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 

    1070                 1075                 1080             





Gly Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 

    1085                 1090                 1095             





Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly Pro Gly  Ser Glu Pro 

    1100                 1105                 1110             





Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Ser Glu Pro  Ala Thr Ser 

    1115                 1120                 1125             





Gly Ser  Glu Thr Pro Gly Ser  Pro Ala Gly Ser Pro  Thr Ser Thr 

    1130                 1135                 1140             





Glu Glu  Gly Thr Ser Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Gly 

    1145                 1150                 1155             





Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Ser Glu Pro 

    1160                 1165                 1170             





Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr 

    1175                 1180                 1185             





Pro Glu  Ser Gly Pro Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser 

    1190                 1195                 1200             





Ala Pro  Ala Ser Ser Pro Pro  Val Leu Lys Arg His  Gln Ala Glu 

    1205                 1210                 1215             





Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 

    1220                 1225                 1230             





Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 

    1235                 1240                 1245             





Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 

    1250                 1255                 1260             





Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 

    1265                 1270                 1275             





Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 

    1280                 1285                 1290             





Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 

    1295                 1300                 1305             





Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 

    1310                 1315                 1320             





His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 

    1325                 1330                 1335             





Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 

    1340                 1345                 1350             





Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 

    1355                 1360                 1365             





Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 

    1370                 1375                 1380             





Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 

    1385                 1390                 1395             





Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 

    1400                 1405                 1410             





Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 

    1415                 1420                 1425             





Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 

    1430                 1435                 1440             





Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 

    1445                 1450                 1455             





Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 

    1460                 1465                 1470             





Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 

    1475                 1480                 1485             





Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 

    1490                 1495                 1500             





Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 

    1505                 1510                 1515             





Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 

    1520                 1525                 1530             





Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 

    1535                 1540                 1545             





Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 

    1550                 1555                 1560             





Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 

    1565                 1570                 1575             





Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 

    1580                 1585                 1590             





Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 

    1595                 1600                 1605             





Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 

    1610                 1615                 1620             





Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 

    1625                 1630                 1635             





Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 

    1640                 1645                 1650             





Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 

    1655                 1660                 1665             





Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 

    1670                 1675                 1680             





Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 

    1685                 1690                 1695             





Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 

    1700                 1705                 1710             





Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 

    1715                 1720                 1725             





Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 

    1730                 1735                 1740             





Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 

    1745                 1750                 1755             





Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 

    1760                 1765                 1770             





Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 

    1775                 1780                 1785             





Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 

    1790                 1795                 1800             





Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 

    1805                 1810                 1815             





Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 

    1820                 1825                 1830             





Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 

    1835                 1840                 1845             





Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 

    1850                 1855                 1860             





Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 

    1865                 1870                 1875             





Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 

    1880                 1885                 1890             





Gly Cys  Glu Ala Gln Asp Leu  Tyr Asp Lys Thr His  Thr Cys Pro 

    1895                 1900                 1905             





Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu 

    1910                 1915                 1920             





Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro 

    1925                 1930                 1935             





Glu Val  Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 

    1940                 1945                 1950             





Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 

    1955                 1960                 1965             





Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 

    1970                 1975                 1980             





Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 

    1985                 1990                 1995             





Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 

    2000                 2005                 2010             





Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 

    2015                 2020                 2025             





Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 

    2030                 2035                 2040             





Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 

    2045                 2050                 2055             





Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 

    2060                 2065                 2070             





Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 

    2075                 2080                 2085             





Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 

    2090                 2095                 2100             





Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 

    2105                 2110                 2115             





Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 

    2120                 2125             





<210>  112

<211>  2020

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN FVIII 266 protein sequence



<400>  112



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 

        35                  40                  45              





Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

    50                  55                  60                  





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser Ser 

65                  70                  75                  80  





Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro 

                85                  90                  95      





Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe 

            100                 105                 110         





Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro 

        115                 120                 125             





Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr 

    130                 135                 140                 





Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His 

145                 150                 155                 160 





Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp 

                165                 170                 175     





Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly 

            180                 185                 190         





Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met 

        195                 200                 205             





Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp 

    210                 215                 220                 





Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys 

225                 230                 235                 240 





Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe 

                245                 250                 255     





Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu 

            260                 265                 270         





Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala 

        275                 280                 285             





Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro 

    290                 295                 300                 





Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly 

305                 310                 315                 320 





Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr 

                325                 330                 335     





Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile 

            340                 345                 350         





Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu 

        355                 360                 365             





Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr 

    370                 375                 380                 





Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn 

385                 390                 395                 400 





Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met 

                405                 410                 415     





Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile 

            420                 425                 430         





Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 

        435                 440                 445             





Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 

    450                 455                 460                 





Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 

465                 470                 475                 480 





Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 

                485                 490                 495     





Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 

            500                 505                 510         





Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 

        515                 520                 525             





Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 

    530                 535                 540                 





Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 

545                 550                 555                 560 





Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 

                565                 570                 575     





Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 

            580                 585                 590         





Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 

        595                 600                 605             





Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 

    610                 615                 620                 





Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 

625                 630                 635                 640 





Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 

                645                 650                 655     





Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 

            660                 665                 670         





Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 

        675                 680                 685             





Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 

    690                 695                 700                 





Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 

705                 710                 715                 720 





His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 

                725                 730                 735     





Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 

            740                 745                 750         





Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 

        755                 760                 765             





Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 

    770                 775                 780                 





Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 

785                 790                 795                 800 





Arg Ser Phe Ser Gln Asn Gly Ala Pro Gly Thr Ser Glu Ser Ala Thr 

                805                 810                 815     





Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 

            820                 825                 830         





Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 

        835                 840                 845             





Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 

    850                 855                 860                 





Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 

865                 870                 875                 880 





Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 

                885                 890                 895     





Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 

            900                 905                 910         





Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

        915                 920                 925             





Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 

    930                 935                 940                 





Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 

945                 950                 955                 960 





Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

                965                 970                 975     





Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 

            980                 985                 990         





Glu Ser Ala Thr Pro Glu Ser Gly  Pro Gly Ser Glu Pro  Ala Thr Ser 

        995                 1000                 1005             





Gly Ser  Glu Thr Pro Gly Ser  Glu Pro Ala Thr Ser  Gly Ser Glu 

    1010                 1015                 1020             





Thr Pro  Gly Ser Pro Ala Gly  Ser Pro Thr Ser Thr  Glu Glu Gly 

    1025                 1030                 1035             





Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Thr Ser Thr 

    1040                 1045                 1050             





Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ser Glu Pro  Ala Thr Ser 

    1055                 1060                 1065             





Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 

    1070                 1075                 1080             





Gly Pro  Gly Thr Ser Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Ala 

    1085                 1090                 1095             





Ser Ser  Pro Pro Val Leu Lys  Arg His Gln Ala Glu  Ile Thr Arg 

    1100                 1105                 1110             





Thr Thr  Leu Gln Ser Asp Gln  Glu Glu Ile Asp Tyr  Asp Asp Thr 

    1115                 1120                 1125             





Ile Ser  Val Glu Met Lys Lys  Glu Asp Phe Asp Ile  Tyr Asp Glu 

    1130                 1135                 1140             





Asp Glu  Asn Gln Ser Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His 

    1145                 1150                 1155             





Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser 

    1160                 1165                 1170             





Ser Ser  Pro His Val Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val 

    1175                 1180                 1185             





Pro Gln  Phe Lys Lys Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser 

    1190                 1195                 1200             





Phe Thr  Gln Pro Leu Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly 

    1205                 1210                 1215             





Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met 

    1220                 1225                 1230             





Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser 

    1235                 1240                 1245             





Ser Leu  Ile Ser Tyr Glu Glu  Asp Gln Arg Gln Gly  Ala Glu Pro 

    1250                 1255                 1260             





Arg Lys  Asn Phe Val Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp 

    1265                 1270                 1275             





Lys Val  Gln His His Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys 

    1280                 1285                 1290             





Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val 

    1295                 1300                 1305             





His Ser  Gly Leu Ile Gly Pro  Leu Leu Val Cys His  Thr Asn Thr 

    1310                 1315                 1320             





Leu Asn  Pro Ala His Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala 

    1325                 1330                 1335             





Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr 

    1340                 1345                 1350             





Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met 

    1355                 1360                 1365             





Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn 

    1370                 1375                 1380             





Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp 

    1385                 1390                 1395             





Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn 

    1400                 1405                 1410             





Ile His  Ser Ile His Phe Ser  Gly His Val Phe Thr  Val Arg Lys 

    1415                 1420                 1425             





Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val 

    1430                 1435                 1440             





Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg 

    1445                 1450                 1455             





Val Glu  Cys Leu Ile Gly Glu  His Leu His Ala Gly  Met Ser Thr 

    1460                 1465                 1470             





Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met 

    1475                 1480                 1485             





Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln 

    1490                 1495                 1500             





Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly 

    1505                 1510                 1515             





Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys 

    1520                 1525                 1530             





Val Asp  Leu Leu Ala Pro Met  Ile Ile His Gly Ile  Lys Thr Gln 

    1535                 1540                 1545             





Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile 

    1550                 1555                 1560             





Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly 

    1565                 1570                 1575             





Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe Gly Asn  Val Asp Ser 

    1580                 1585                 1590             





Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg 

    1595                 1600                 1605             





Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu 

    1610                 1615                 1620             





Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro 

    1625                 1630                 1635             





Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala 

    1640                 1645                 1650             





Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys 

    1655                 1660                 1665             





Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln 

    1670                 1675                 1680             





Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr 

    1685                 1690                 1695             





Met Lys  Val Thr Gly Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu 

    1700                 1705                 1710             





Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp 

    1715                 1720                 1725             





Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val 

    1730                 1735                 1740             





Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu 

    1745                 1750                 1755             





Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser 

    1760                 1765                 1770             





Trp Val  His Gln Ile Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu 

    1775                 1780                 1785             





Ala Gln  Asp Leu Tyr Asp Lys  Thr His Thr Cys Pro  Pro Cys Pro 

    1790                 1795                 1800             





Ala Pro  Glu Leu Leu Gly Gly  Pro Ser Val Phe Leu  Phe Pro Pro 

    1805                 1810                 1815             





Lys Pro  Lys Asp Thr Leu Met  Ile Ser Arg Thr Pro  Glu Val Thr 

    1820                 1825                 1830             





Cys Val  Val Val Asp Val Ser  His Glu Asp Pro Glu  Val Lys Phe 

    1835                 1840                 1845             





Asn Trp  Tyr Val Asp Gly Val  Glu Val His Asn Ala  Lys Thr Lys 

    1850                 1855                 1860             





Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr Arg Val  Val Ser Val 

    1865                 1870                 1875             





Leu Thr  Val Leu His Gln Asp  Trp Leu Asn Gly Lys  Glu Tyr Lys 

    1880                 1885                 1890             





Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala Pro Ile  Glu Lys Thr 

    1895                 1900                 1905             





Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu Pro Gln  Val Tyr Thr 

    1910                 1915                 1920             





Leu Pro  Pro Ser Arg Asp Glu  Leu Thr Lys Asn Gln  Val Ser Leu 

    1925                 1930                 1935             





Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu 

    1940                 1945                 1950             





Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro 

    1955                 1960                 1965             





Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 

    1970                 1975                 1980             





Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 

    1985                 1990                 1995             





Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 

    2000                 2005                 2010             





Leu Ser  Leu Ser Pro Gly Lys  

    2015                 2020 





<210>  113

<211>  2056

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN FVIII 267 protein sequence



<400>  113



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu 

        35                  40                  45              





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

    50                  55                  60                  





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

65                  70                  75                  80  





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

                85                  90                  95      





Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

            100                 105                 110         





Ala Ser Ser Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro 

        115                 120                 125             





Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys 

    130                 135                 140                 





Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys 

145                 150                 155                 160 





Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu 

                165                 170                 175     





Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro 

            180                 185                 190         





Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly 

        195                 200                 205             





Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys 

    210                 215                 220                 





Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu 

225                 230                 235                 240 





Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu 

                245                 250                 255     





Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala 

            260                 265                 270         





Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr 

        275                 280                 285             





Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser 

    290                 295                 300                 





Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala 

305                 310                 315                 320 





Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn 

                325                 330                 335     





Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp 

            340                 345                 350         





His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu 

        355                 360                 365             





Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu 

    370                 375                 380                 





Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu 

385                 390                 395                 400 





Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly 

                405                 410                 415     





Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu 

            420                 425                 430         





Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr 

        435                 440                 445             





Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser 

    450                 455                 460                 





Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val 

465                 470                 475                 480 





His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val 

                485                 490                 495     





Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly 

            500                 505                 510         





Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr 

        515                 520                 525             





Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly 

    530                 535                 540                 





Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile 

545                 550                 555                 560 





Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly 

                565                 570                 575     





Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val 

            580                 585                 590         





Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr 

        595                 600                 605             





Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg 

    610                 615                 620                 





Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu 

625                 630                 635                 640 





Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val 

                645                 650                 655     





Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu 

            660                 665                 670         





Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile 

        675                 680                 685             





Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu 

    690                 695                 700                 





Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp 

705                 710                 715                 720 





Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile 

                725                 730                 735     





Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly 

            740                 745                 750         





Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe 

        755                 760                 765             





Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu 

    770                 775                 780                 





Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr 

785                 790                 795                 800 





Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr 

                805                 810                 815     





Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn 

            820                 825                 830         





Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Ala Pro Gly Thr Ser 

        835                 840                 845             





Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 

    850                 855                 860                 





Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

865                 870                 875                 880 





Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 

                885                 890                 895     





Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 

            900                 905                 910         





Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 

        915                 920                 925             





Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 

    930                 935                 940                 





Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 

945                 950                 955                 960 





Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 

                965                 970                 975     





Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 

            980                 985                 990         





Thr Glu Pro Ser Glu Gly Ser Ala  Pro Gly Thr Ser Glu  Ser Ala Thr 

        995                 1000                 1005             





Pro Glu  Ser Gly Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 

    1010                 1015                 1020             





Gly Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 

    1025                 1030                 1035             





Ser Glu  Pro Ala Thr Ser Gly  Ser Glu Thr Pro Gly  Ser Glu Pro 

    1040                 1045                 1050             





Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Ser Pro Ala  Gly Ser Pro 

    1055                 1060                 1065             





Thr Ser  Thr Glu Glu Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser 

    1070                 1075                 1080             





Ala Pro  Gly Thr Ser Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Gly 

    1085                 1090                 1095             





Ser Glu  Pro Ala Thr Ser Gly  Ser Glu Thr Pro Gly  Thr Ser Glu 

    1100                 1105                 1110             





Ser Ala  Thr Pro Glu Ser Gly  Pro Gly Thr Ser Thr  Glu Pro Ser 

    1115                 1120                 1125             





Glu Gly  Ser Ala Pro Ala Ser  Ser Pro Pro Val Leu  Lys Arg His 

    1130                 1135                 1140             





Gln Ala  Glu Ile Thr Arg Thr  Thr Leu Gln Ser Asp  Gln Glu Glu 

    1145                 1150                 1155             





Ile Asp  Tyr Asp Asp Thr Ile  Ser Val Glu Met Lys  Lys Glu Asp 

    1160                 1165                 1170             





Phe Asp  Ile Tyr Asp Glu Asp  Glu Asn Gln Ser Pro  Arg Ser Phe 

    1175                 1180                 1185             





Gln Lys  Lys Thr Arg His Tyr  Phe Ile Ala Ala Val  Glu Arg Leu 

    1190                 1195                 1200             





Trp Asp  Tyr Gly Met Ser Ser  Ser Pro His Val Leu  Arg Asn Arg 

    1205                 1210                 1215             





Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys Lys Val  Val Phe Gln 

    1220                 1225                 1230             





Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro Leu Tyr  Arg Gly Glu 

    1235                 1240                 1245             





Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu 

    1250                 1255                 1260             





Val Glu  Asp Asn Ile Met Val  Thr Phe Arg Asn Gln  Ala Ser Arg 

    1265                 1270                 1275             





Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser Tyr Glu  Glu Asp Gln 

    1280                 1285                 1290             





Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe Val Lys  Pro Asn Glu 

    1295                 1300                 1305             





Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 

    1310                 1315                 1320             





Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 

    1325                 1330                 1335             





Asp Leu  Glu Lys Asp Val His  Ser Gly Leu Ile Gly  Pro Leu Leu 

    1340                 1345                 1350             





Val Cys  His Thr Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 

    1355                 1360                 1365             





Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr 

    1370                 1375                 1380             





Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala 

    1385                 1390                 1395             





Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr 

    1400                 1405                 1410             





Arg Phe  His Ala Ile Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly 

    1415                 1420                 1425             





Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 

    1430                 1435                 1440             





Met Gly  Ser Asn Glu Asn Ile  His Ser Ile His Phe  Ser Gly His 

    1445                 1450                 1455             





Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr 

    1460                 1465                 1470             





Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val Glu Met  Leu Pro Ser 

    1475                 1480                 1485             





Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 

    1490                 1495                 1500             





His Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys 

    1505                 1510                 1515             





Gln Thr  Pro Leu Gly Met Ala  Ser Gly His Ile Arg  Asp Phe Gln 

    1520                 1525                 1530             





Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala 

    1535                 1540                 1545             





Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 

    1550                 1555                 1560             





Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile 

    1565                 1570                 1575             





His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 

    1580                 1585                 1590             





Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 

    1595                 1600                 1605             





Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 

    1610                 1615                 1620             





Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn 

    1625                 1630                 1635             





Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr 

    1640                 1645                 1650             





Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 

    1655                 1660                 1665             





Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser 

    1670                 1675                 1680             





Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 

    1685                 1690                 1695             





Thr Trp  Ser Pro Ser Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser 

    1700                 1705                 1710             





Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln 

    1715                 1720                 1725             





Val Asp  Phe Gln Lys Thr Met  Lys Val Thr Gly Val  Thr Thr Gln 

    1730                 1735                 1740             





Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu 

    1745                 1750                 1755             





Ile Ser  Ser Ser Gln Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln 

    1760                 1765                 1770             





Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr 

    1775                 1780                 1785             





Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 

    1790                 1795                 1800             





Arg Ile  His Pro Gln Ser Trp  Val His Gln Ile Ala  Leu Arg Met 

    1805                 1810                 1815             





Glu Val  Leu Gly Cys Glu Ala  Gln Asp Leu Tyr Asp  Lys Thr His 

    1820                 1825                 1830             





Thr Cys  Pro Pro Cys Pro Ala  Pro Glu Leu Leu Gly  Gly Pro Ser 

    1835                 1840                 1845             





Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser 

    1850                 1855                 1860             





Arg Thr  Pro Glu Val Thr Cys  Val Val Val Asp Val  Ser His Glu 

    1865                 1870                 1875             





Asp Pro  Glu Val Lys Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 

    1880                 1885                 1890             





His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr 

    1895                 1900                 1905             





Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 

    1910                 1915                 1920             





Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro 

    1925                 1930                 1935             





Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 

    1940                 1945                 1950             





Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Arg Asp  Glu Leu Thr 

    1955                 1960                 1965             





Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 

    1970                 1975                 1980             





Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 

    1985                 1990                 1995             





Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 

    2000                 2005                 2010             





Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln 

    2015                 2020                 2025             





Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 

    2030                 2035                 2040             





His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Pro Gly  Lys 

    2045                 2050                 2055     





<210>  114

<211>  1834

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN FVIII 268 protein sequence



<400>  114



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu 

        35                  40                  45              





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

    50                  55                  60                  





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

65                  70                  75                  80  





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

                85                  90                  95      





Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

            100                 105                 110         





Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 

        115                 120                 125             





Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 

    130                 135                 140                 





Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

145                 150                 155                 160 





Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 

                165                 170                 175     





Ser Pro Thr Ser Thr Glu Glu Gly Ala Ser Ser Ser Asp Leu Gly Glu 

            180                 185                 190         





Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro 

        195                 200                 205             





Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr 

    210                 215                 220                 





Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu 

225                 230                 235                 240 





Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr 

                245                 250                 255     





Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val 

            260                 265                 270         





Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser 

        275                 280                 285             





Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 

    290                 295                 300                 





Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 

305                 310                 315                 320 





Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 

                325                 330                 335     





Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 

            340                 345                 350         





Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 

        355                 360                 365             





Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 

    370                 375                 380                 





Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 

385                 390                 395                 400 





His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 

                405                 410                 415     





Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 

            420                 425                 430         





Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 

        435                 440                 445             





Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 

    450                 455                 460                 





Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 

465                 470                 475                 480 





Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 

                485                 490                 495     





Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 

            500                 505                 510         





Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 

        515                 520                 525             





Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 

    530                 535                 540                 





Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 

545                 550                 555                 560 





Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 

                565                 570                 575     





Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 

            580                 585                 590         





Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 

        595                 600                 605             





Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 

    610                 615                 620                 





Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 

625                 630                 635                 640 





Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 

                645                 650                 655     





Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 

            660                 665                 670         





Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 

        675                 680                 685             





Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 

    690                 695                 700                 





Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 

705                 710                 715                 720 





Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 

                725                 730                 735     





Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 

            740                 745                 750         





Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 

        755                 760                 765             





Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 

    770                 775                 780                 





Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 

785                 790                 795                 800 





His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 

                805                 810                 815     





Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 

            820                 825                 830         





Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 

        835                 840                 845             





Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 

    850                 855                 860                 





Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 

865                 870                 875                 880 





Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 

                885                 890                 895     





Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 

            900                 905                 910         





Gln Asn Pro Pro Val Leu Lys Arg His Gln Ala Glu Ile Thr Arg Thr 

        915                 920                 925             





Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 

    930                 935                 940                 





Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 

945                 950                 955                 960 





Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 

                965                 970                 975     





Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 

            980                 985                 990         





Leu Arg Asn Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 

        995                 1000                 1005             





Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 

    1010                 1015                 1020             





Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 

    1025                 1030                 1035             





Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln 

    1040                 1045                 1050             





Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 

    1055                 1060                 1065             





Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys 

    1070                 1075                 1080             





Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys Val Gln  His His Met 

    1085                 1090                 1095             





Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 

    1100                 1105                 1110             





Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 

    1115                 1120                 1125             





Pro Leu  Leu Val Cys His Thr  Asn Thr Leu Asn Pro  Ala His Gly 

    1130                 1135                 1140             





Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 

    1145                 1150                 1155             





Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 

    1160                 1165                 1170             





Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 

    1175                 1180                 1185             





Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 

    1190                 1195                 1200             





Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 

    1205                 1210                 1215             





Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 

    1220                 1225                 1230             





Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 

    1235                 1240                 1245             





Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 

    1250                 1255                 1260             





Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 

    1265                 1270                 1275             





Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 

    1280                 1285                 1290             





Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 

    1295                 1300                 1305             





Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 

    1310                 1315                 1320             





Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 

    1325                 1330                 1335             





Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 

    1340                 1345                 1350             





Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 

    1355                 1360                 1365             





Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 

    1370                 1375                 1380             





Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 

    1385                 1390                 1395             





Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 

    1400                 1405                 1410             





Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 

    1415                 1420                 1425             





Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 

    1430                 1435                 1440             





Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 

    1445                 1450                 1455             





Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 

    1460                 1465                 1470             





Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 

    1475                 1480                 1485             





Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 

    1490                 1495                 1500             





Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 

    1505                 1510                 1515             





Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 

    1520                 1525                 1530             





Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 

    1535                 1540                 1545             





Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 

    1550                 1555                 1560             





Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 

    1565                 1570                 1575             





Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 

    1580                 1585                 1590             





Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Asp 

    1595                 1600                 1605             





Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 

    1610                 1615                 1620             





Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 

    1625                 1630                 1635             





Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 

    1640                 1645                 1650             





Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 

    1655                 1660                 1665             





Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 

    1670                 1675                 1680             





Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 

    1685                 1690                 1695             





Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 

    1700                 1705                 1710             





Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 

    1715                 1720                 1725             





Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 

    1730                 1735                 1740             





Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 

    1745                 1750                 1755             





Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 

    1760                 1765                 1770             





Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 

    1775                 1780                 1785             





Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 

    1790                 1795                 1800             





Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 

    1805                 1810                 1815             





Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 

    1820                 1825                 1830             





Lys 

    





<210>  115

<211>  1762

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN FVIII 269 protein sequence



<400>  115



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu 

        35                  40                  45              





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

    50                  55                  60                  





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

65                  70                  75                  80  





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

                85                  90                  95      





Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

            100                 105                 110         





Ala Ser Ser Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro 

        115                 120                 125             





Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys 

    130                 135                 140                 





Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys 

145                 150                 155                 160 





Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu 

                165                 170                 175     





Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro 

            180                 185                 190         





Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly 

        195                 200                 205             





Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys 

    210                 215                 220                 





Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu 

225                 230                 235                 240 





Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu 

                245                 250                 255     





Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala 

            260                 265                 270         





Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr 

        275                 280                 285             





Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser 

    290                 295                 300                 





Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala 

305                 310                 315                 320 





Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn 

                325                 330                 335     





Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp 

            340                 345                 350         





His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu 

        355                 360                 365             





Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu 

    370                 375                 380                 





Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu 

385                 390                 395                 400 





Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly 

                405                 410                 415     





Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu 

            420                 425                 430         





Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr 

        435                 440                 445             





Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser 

    450                 455                 460                 





Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val 

465                 470                 475                 480 





His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val 

                485                 490                 495     





Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly 

            500                 505                 510         





Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr 

        515                 520                 525             





Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly 

    530                 535                 540                 





Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile 

545                 550                 555                 560 





Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly 

                565                 570                 575     





Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val 

            580                 585                 590         





Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr 

        595                 600                 605             





Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg 

    610                 615                 620                 





Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu 

625                 630                 635                 640 





Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val 

                645                 650                 655     





Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu 

            660                 665                 670         





Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile 

        675                 680                 685             





Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu 

    690                 695                 700                 





Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp 

705                 710                 715                 720 





Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile 

                725                 730                 735     





Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly 

            740                 745                 750         





Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe 

        755                 760                 765             





Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu 

    770                 775                 780                 





Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr 

785                 790                 795                 800 





Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr 

                805                 810                 815     





Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn 

            820                 825                 830         





Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg 

        835                 840                 845             





His Gln Ala Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu 

    850                 855                 860                 





Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe 

865                 870                 875                 880 





Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys 

                885                 890                 895     





Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr 

            900                 905                 910         





Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly 

        915                 920                 925             





Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly 

    930                 935                 940                 





Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly 

945                 950                 955                 960 





Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val 

                965                 970                 975     





Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu 

            980                 985                 990         





Ile Ser Tyr Glu Glu Asp Gln Arg  Gln Gly Ala Glu Pro  Arg Lys Asn 

        995                 1000                 1005             





Phe Val  Lys Pro Asn Glu Thr  Lys Thr Tyr Phe Trp  Lys Val Gln 

    1010                 1015                 1020             





His His  Met Ala Pro Thr Lys  Asp Glu Phe Asp Cys  Lys Ala Trp 

    1025                 1030                 1035             





Ala Tyr  Phe Ser Asp Val Asp  Leu Glu Lys Asp Val  His Ser Gly 

    1040                 1045                 1050             





Leu Ile  Gly Pro Leu Leu Val  Cys His Thr Asn Thr  Leu Asn Pro 

    1055                 1060                 1065             





Ala His  Gly Arg Gln Val Thr  Val Gln Glu Phe Ala  Leu Phe Phe 

    1070                 1075                 1080             





Thr Ile  Phe Asp Glu Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met 

    1085                 1090                 1095             





Glu Arg  Asn Cys Arg Ala Pro  Cys Asn Ile Gln Met  Glu Asp Pro 

    1100                 1105                 1110             





Thr Phe  Lys Glu Asn Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Ile 

    1115                 1120                 1125             





Met Asp  Thr Leu Pro Gly Leu  Val Met Ala Gln Asp  Gln Arg Ile 

    1130                 1135                 1140             





Arg Trp  Tyr Leu Leu Ser Met  Gly Ser Asn Glu Asn  Ile His Ser 

    1145                 1150                 1155             





Ile His  Phe Ser Gly His Val  Phe Thr Val Arg Lys  Lys Glu Glu 

    1160                 1165                 1170             





Tyr Lys  Met Ala Leu Tyr Asn  Leu Tyr Pro Gly Val  Phe Glu Thr 

    1175                 1180                 1185             





Val Glu  Met Leu Pro Ser Lys  Ala Gly Ile Trp Arg  Val Glu Cys 

    1190                 1195                 1200             





Leu Ile  Gly Glu His Leu His  Ala Gly Met Ser Thr  Leu Phe Leu 

    1205                 1210                 1215             





Val Tyr  Ser Asn Lys Cys Gln  Thr Pro Leu Gly Met  Ala Ser Gly 

    1220                 1225                 1230             





His Ile  Arg Asp Phe Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln 

    1235                 1240                 1245             





Trp Ala  Pro Lys Leu Ala Arg  Leu His Tyr Ser Gly  Ser Ile Asn 

    1250                 1255                 1260             





Ala Trp  Ser Thr Lys Glu Pro  Phe Ser Trp Ile Lys  Val Asp Leu 

    1265                 1270                 1275             





Leu Ala  Pro Met Ile Ile His  Gly Ile Lys Thr Gln  Gly Ala Arg 

    1280                 1285                 1290             





Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln Phe Ile  Ile Met Tyr 

    1295                 1300                 1305             





Ser Leu  Asp Gly Lys Lys Trp  Gln Thr Tyr Arg Gly  Asn Ser Thr 

    1310                 1315                 1320             





Gly Thr  Leu Met Val Phe Phe  Gly Asn Val Asp Ser  Ser Gly Ile 

    1325                 1330                 1335             





Lys His  Asn Ile Phe Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg 

    1340                 1345                 1350             





Leu His  Pro Thr His Tyr Ser  Ile Arg Ser Thr Leu  Arg Met Glu 

    1355                 1360                 1365             





Leu Met  Gly Cys Asp Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met 

    1370                 1375                 1380             





Glu Ser  Lys Ala Ile Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr 

    1385                 1390                 1395             





Phe Thr  Asn Met Phe Ala Thr  Trp Ser Pro Ser Lys  Ala Arg Leu 

    1400                 1405                 1410             





His Leu  Gln Gly Arg Ser Asn  Ala Trp Arg Pro Gln  Val Asn Asn 

    1415                 1420                 1425             





Pro Lys  Glu Trp Leu Gln Val  Asp Phe Gln Lys Thr  Met Lys Val 

    1430                 1435                 1440             





Thr Gly  Val Thr Thr Gln Gly  Val Lys Ser Leu Leu  Thr Ser Met 

    1445                 1450                 1455             





Tyr Val  Lys Glu Phe Leu Ile  Ser Ser Ser Gln Asp  Gly His Gln 

    1460                 1465                 1470             





Trp Thr  Leu Phe Phe Gln Asn  Gly Lys Val Lys Val  Phe Gln Gly 

    1475                 1480                 1485             





Asn Gln  Asp Ser Phe Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro 

    1490                 1495                 1500             





Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro Gln Ser  Trp Val His 

    1505                 1510                 1515             





Gln Ile  Ala Leu Arg Met Glu  Val Leu Gly Cys Glu  Ala Gln Asp 

    1520                 1525                 1530             





Leu Tyr  Asp Lys Thr His Thr  Cys Pro Pro Cys Pro  Ala Pro Glu 

    1535                 1540                 1545             





Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe Pro Pro  Lys Pro Lys 

    1550                 1555                 1560             





Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu Val Thr  Cys Val Val 

    1565                 1570                 1575             





Val Asp  Val Ser His Glu Asp  Pro Glu Val Lys Phe  Asn Trp Tyr 

    1580                 1585                 1590             





Val Asp  Gly Val Glu Val His  Asn Ala Lys Thr Lys  Pro Arg Glu 

    1595                 1600                 1605             





Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val Ser Val  Leu Thr Val 

    1610                 1615                 1620             





Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu Tyr Lys  Cys Lys Val 

    1625                 1630                 1635             





Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu Lys Thr  Ile Ser Lys 

    1640                 1645                 1650             





Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val Tyr Thr  Leu Pro Pro 

    1655                 1660                 1665             





Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val Ser Leu  Thr Cys Leu 

    1670                 1675                 1680             





Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala Val Glu  Trp Glu Ser 

    1685                 1690                 1695             





Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 

    1700                 1705                 1710             





Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 

    1715                 1720                 1725             





Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 

    1730                 1735                 1740             





His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 

    1745                 1750                 1755             





Ser Pro  Gly Lys 

    1760         





<210>  116

<211>  1726

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYNFVIII  271 protein sequence



<400>  116



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 

        35                  40                  45              





Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

    50                  55                  60                  





Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser Ser 

65                  70                  75                  80  





Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro 

                85                  90                  95      





Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe 

            100                 105                 110         





Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro 

        115                 120                 125             





Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr 

    130                 135                 140                 





Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His 

145                 150                 155                 160 





Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp 

                165                 170                 175     





Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly 

            180                 185                 190         





Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met 

        195                 200                 205             





Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp 

    210                 215                 220                 





Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys 

225                 230                 235                 240 





Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe 

                245                 250                 255     





Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu 

            260                 265                 270         





Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala 

        275                 280                 285             





Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro 

    290                 295                 300                 





Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly 

305                 310                 315                 320 





Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr 

                325                 330                 335     





Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile 

            340                 345                 350         





Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu 

        355                 360                 365             





Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr 

    370                 375                 380                 





Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn 

385                 390                 395                 400 





Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met 

                405                 410                 415     





Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile 

            420                 425                 430         





Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 

        435                 440                 445             





Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 

    450                 455                 460                 





Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 

465                 470                 475                 480 





Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 

                485                 490                 495     





Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 

            500                 505                 510         





Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 

        515                 520                 525             





Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 

    530                 535                 540                 





Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 

545                 550                 555                 560 





Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 

                565                 570                 575     





Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 

            580                 585                 590         





Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 

        595                 600                 605             





Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 

    610                 615                 620                 





Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 

625                 630                 635                 640 





Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 

                645                 650                 655     





Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 

            660                 665                 670         





Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 

        675                 680                 685             





Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 

    690                 695                 700                 





Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 

705                 710                 715                 720 





His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 

                725                 730                 735     





Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 

            740                 745                 750         





Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 

        755                 760                 765             





Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 

    770                 775                 780                 





Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 

785                 790                 795                 800 





Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Ala Glu 

                805                 810                 815     





Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 

            820                 825                 830         





Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 

        835                 840                 845             





Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 

    850                 855                 860                 





Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 

865                 870                 875                 880 





Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 

                885                 890                 895     





Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 

            900                 905                 910         





Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 

        915                 920                 925             





Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 

    930                 935                 940                 





Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 

945                 950                 955                 960 





Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 

                965                 970                 975     





Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 

            980                 985                 990         





Thr Lys Asp Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 

        995                 1000                 1005             





Asp Leu  Glu Lys Asp Val His  Ser Gly Leu Ile Gly  Pro Leu Leu 

    1010                 1015                 1020             





Val Cys  His Thr Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 

    1025                 1030                 1035             





Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr 

    1040                 1045                 1050             





Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala 

    1055                 1060                 1065             





Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr 

    1070                 1075                 1080             





Arg Phe  His Ala Ile Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly 

    1085                 1090                 1095             





Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 

    1100                 1105                 1110             





Met Gly  Ser Asn Glu Asn Ile  His Ser Ile His Phe  Ser Gly His 

    1115                 1120                 1125             





Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr 

    1130                 1135                 1140             





Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val Glu Met  Leu Pro Ser 

    1145                 1150                 1155             





Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 

    1160                 1165                 1170             





His Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys 

    1175                 1180                 1185             





Gln Thr  Pro Leu Gly Met Ala  Ser Gly His Ile Arg  Asp Phe Gln 

    1190                 1195                 1200             





Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala 

    1205                 1210                 1215             





Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 

    1220                 1225                 1230             





Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile 

    1235                 1240                 1245             





His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 

    1250                 1255                 1260             





Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 

    1265                 1270                 1275             





Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 

    1280                 1285                 1290             





Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn 

    1295                 1300                 1305             





Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr 

    1310                 1315                 1320             





Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 

    1325                 1330                 1335             





Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser 

    1340                 1345                 1350             





Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 

    1355                 1360                 1365             





Thr Trp  Ser Pro Ser Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser 

    1370                 1375                 1380             





Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln 

    1385                 1390                 1395             





Val Asp  Phe Gln Lys Thr Met  Lys Val Thr Gly Val  Thr Thr Gln 

    1400                 1405                 1410             





Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu 

    1415                 1420                 1425             





Ile Ser  Ser Ser Gln Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln 

    1430                 1435                 1440             





Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr 

    1445                 1450                 1455             





Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 

    1460                 1465                 1470             





Arg Ile  His Pro Gln Ser Trp  Val His Gln Ile Ala  Leu Arg Met 

    1475                 1480                 1485             





Glu Val  Leu Gly Cys Glu Ala  Gln Asp Leu Tyr Asp  Lys Thr His 

    1490                 1495                 1500             





Thr Cys  Pro Pro Cys Pro Ala  Pro Glu Leu Leu Gly  Gly Pro Ser 

    1505                 1510                 1515             





Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser 

    1520                 1525                 1530             





Arg Thr  Pro Glu Val Thr Cys  Val Val Val Asp Val  Ser His Glu 

    1535                 1540                 1545             





Asp Pro  Glu Val Lys Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 

    1550                 1555                 1560             





His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr 

    1565                 1570                 1575             





Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 

    1580                 1585                 1590             





Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro 

    1595                 1600                 1605             





Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 

    1610                 1615                 1620             





Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Arg Asp  Glu Leu Thr 

    1625                 1630                 1635             





Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 

    1640                 1645                 1650             





Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 

    1655                 1660                 1665             





Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 

    1670                 1675                 1680             





Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln 

    1685                 1690                 1695             





Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 

    1700                 1705                 1710             





His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Pro Gly  Lys 

    1715                 1720                 1725     





<210>  117

<211>  1901

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN FVIII protein sequence 272



<400>  117



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu 

        35                  40                  45              





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

    50                  55                  60                  





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

65                  70                  75                  80  





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

                85                  90                  95      





Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

            100                 105                 110         





Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 

        115                 120                 125             





Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 

    130                 135                 140                 





Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

145                 150                 155                 160 





Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 

                165                 170                 175     





Ser Pro Thr Ser Thr Glu Glu Gly Ala Ser Ser Ser Asp Leu Gly Glu 

            180                 185                 190         





Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro 

        195                 200                 205             





Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr 

    210                 215                 220                 





Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu 

225                 230                 235                 240 





Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr 

                245                 250                 255     





Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val 

            260                 265                 270         





Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser 

        275                 280                 285             





Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 

    290                 295                 300                 





Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 

305                 310                 315                 320 





Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 

                325                 330                 335     





Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 

            340                 345                 350         





Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 

        355                 360                 365             





Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 

    370                 375                 380                 





Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 

385                 390                 395                 400 





His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 

                405                 410                 415     





Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 

            420                 425                 430         





Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 

        435                 440                 445             





Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 

    450                 455                 460                 





Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 

465                 470                 475                 480 





Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 

                485                 490                 495     





Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 

            500                 505                 510         





Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 

        515                 520                 525             





Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 

    530                 535                 540                 





Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 

545                 550                 555                 560 





Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 

                565                 570                 575     





Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 

            580                 585                 590         





Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 

        595                 600                 605             





Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 

    610                 615                 620                 





Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 

625                 630                 635                 640 





Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 

                645                 650                 655     





Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 

            660                 665                 670         





Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 

        675                 680                 685             





Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 

    690                 695                 700                 





Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 

705                 710                 715                 720 





Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 

                725                 730                 735     





Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 

            740                 745                 750         





Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 

        755                 760                 765             





Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 

    770                 775                 780                 





Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 

785                 790                 795                 800 





His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 

                805                 810                 815     





Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 

            820                 825                 830         





Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 

        835                 840                 845             





Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 

    850                 855                 860                 





Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 

865                 870                 875                 880 





Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 

                885                 890                 895     





Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 

            900                 905                 910         





Gln Asn Gly Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

        915                 920                 925             





Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 

    930                 935                 940                 





Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 

945                 950                 955                 960 





Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 

                965                 970                 975     





Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 

            980                 985                 990         





Ala Gly Ser Pro Thr Ser Thr Glu  Glu Gly Thr Ser Glu  Ser Ala Thr 

        995                 1000                 1005             





Pro Glu  Ser Gly Pro Gly Ser  Glu Pro Ala Thr Ser  Gly Ser Glu 

    1010                 1015                 1020             





Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 

    1025                 1030                 1035             





Ser Pro  Ala Gly Ser Pro Thr  Ser Thr Glu Glu Gly  Ser Pro Ala 

    1040                 1045                 1050             





Gly Ser  Pro Thr Ser Thr Glu  Glu Gly Thr Ser Thr  Glu Pro Ser 

    1055                 1060                 1065             





Glu Gly  Ser Ala Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 

    1070                 1075                 1080             





Gly Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly 

    1085                 1090                 1095             





Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly Pro Gly  Ser Glu Pro 

    1100                 1105                 1110             





Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Ser Glu Pro  Ala Thr Ser 

    1115                 1120                 1125             





Gly Ser  Glu Thr Pro Gly Ser  Pro Ala Gly Ser Pro  Thr Ser Thr 

    1130                 1135                 1140             





Glu Glu  Gly Thr Ser Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Gly 

    1145                 1150                 1155             





Thr Ser  Thr Glu Pro Ser Glu  Gly Ser Ala Pro Gly  Ser Glu Pro 

    1160                 1165                 1170             





Ala Thr  Ser Gly Ser Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr 

    1175                 1180                 1185             





Pro Glu  Ser Gly Pro Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser 

    1190                 1195                 1200             





Ala Pro  Ala Ser Ser Pro Pro  Val Leu Lys Arg His  Gln Ala Glu 

    1205                 1210                 1215             





Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 

    1220                 1225                 1230             





Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 

    1235                 1240                 1245             





Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 

    1250                 1255                 1260             





Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 

    1265                 1270                 1275             





Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 

    1280                 1285                 1290             





Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 

    1295                 1300                 1305             





Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 

    1310                 1315                 1320             





His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 

    1325                 1330                 1335             





Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 

    1340                 1345                 1350             





Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 

    1355                 1360                 1365             





Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 

    1370                 1375                 1380             





Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 

    1385                 1390                 1395             





Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 

    1400                 1405                 1410             





Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 

    1415                 1420                 1425             





Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 

    1430                 1435                 1440             





Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 

    1445                 1450                 1455             





Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 

    1460                 1465                 1470             





Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 

    1475                 1480                 1485             





Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 

    1490                 1495                 1500             





Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 

    1505                 1510                 1515             





Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 

    1520                 1525                 1530             





Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 

    1535                 1540                 1545             





Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 

    1550                 1555                 1560             





Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 

    1565                 1570                 1575             





Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 

    1580                 1585                 1590             





Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 

    1595                 1600                 1605             





Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 

    1610                 1615                 1620             





Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 

    1625                 1630                 1635             





Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 

    1640                 1645                 1650             





Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 

    1655                 1660                 1665             





Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 

    1670                 1675                 1680             





Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 

    1685                 1690                 1695             





Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 

    1700                 1705                 1710             





Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 

    1715                 1720                 1725             





Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 

    1730                 1735                 1740             





Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 

    1745                 1750                 1755             





Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 

    1760                 1765                 1770             





Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 

    1775                 1780                 1785             





Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 

    1790                 1795                 1800             





Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 

    1805                 1810                 1815             





Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 

    1820                 1825                 1830             





Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 

    1835                 1840                 1845             





Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 

    1850                 1855                 1860             





Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 

    1865                 1870                 1875             





Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 

    1880                 1885                 1890             





Gly Cys  Glu Ala Gln Asp Leu  Tyr 

    1895                 1900     





<210>  118

<211>  1515

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN VWF 031 protein sequence



<400>  118



Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 

1               5                   10                  15      





Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 

            20                  25                  30          





Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 

        35                  40                  45              





Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 

    50                  55                  60                  





Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 

65                  70                  75                  80  





Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 

                85                  90                  95      





Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 

            100                 105                 110         





Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 

        115                 120                 125             





Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 

    130                 135                 140                 





Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 

145                 150                 155                 160 





Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 

                165                 170                 175     





Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 

            180                 185                 190         





Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 

        195                 200                 205             





Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 

    210                 215                 220                 





Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 

225                 230                 235                 240 





Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 

                245                 250                 255     





Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 

            260                 265                 270         





Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 

        275                 280                 285             





Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 

    290                 295                 300                 





Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 

305                 310                 315                 320 





Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 

                325                 330                 335     





Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 

            340                 345                 350         





Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 

        355                 360                 365             





Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 

    370                 375                 380                 





Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 

385                 390                 395                 400 





Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 

                405                 410                 415     





Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 

            420                 425                 430         





Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 

        435                 440                 445             





Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 

    450                 455                 460                 





Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 

465                 470                 475                 480 





Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 

                485                 490                 495     





Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 

            500                 505                 510         





Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 

        515                 520                 525             





Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 

    530                 535                 540                 





Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 

545                 550                 555                 560 





Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 

                565                 570                 575     





Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 

            580                 585                 590         





Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 

        595                 600                 605             





Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 

    610                 615                 620                 





Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 

625                 630                 635                 640 





Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 

                645                 650                 655     





Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 

            660                 665                 670         





Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 

        675                 680                 685             





Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 

    690                 695                 700                 





Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 

705                 710                 715                 720 





Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 

                725                 730                 735     





His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 

            740                 745                 750         





Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 

        755                 760                 765             





Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 

    770                 775                 780                 





Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 

785                 790                 795                 800 





Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 

                805                 810                 815     





His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 

            820                 825                 830         





Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 

        835                 840                 845             





Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 

    850                 855                 860                 





Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 

865                 870                 875                 880 





Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 

                885                 890                 895     





Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 

            900                 905                 910         





Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 

        915                 920                 925             





Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 

    930                 935                 940                 





Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 

945                 950                 955                 960 





Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 

                965                 970                 975     





His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 

            980                 985                 990         





Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 

        995                 1000                 1005             





Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 

    1010                 1015                 1020             





Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 

    1025                 1030                 1035             





Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 

    1040                 1045                 1050             





Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 

    1055                 1060                 1065             





Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 

    1070                 1075                 1080             





Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 

    1085                 1090                 1095             





Ala Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 

    1100                 1105                 1110             





His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 

    1115                 1120                 1125             





Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Ala Glu 

    1130                 1135                 1140             





Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 

    1145                 1150                 1155             





His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 

    1160                 1165                 1170             





His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 

    1175                 1180                 1185             





Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 

    1190                 1195                 1200             





Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 

    1205                 1210                 1215             





Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 

    1220                 1225                 1230             





Cys Glu  Ala Cys Gln Glu Pro  Ile Ser Gly Gly Gly  Gly Ser Gly 

    1235                 1240                 1245             





Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 

    1250                 1255                 1260             





Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Leu Val Pro  Arg Gly Ser 

    1265                 1270                 1275             





Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Asp Lys  Thr His Thr 

    1280                 1285                 1290             





Cys Pro  Pro Cys Pro Ala Pro  Glu Leu Leu Gly Gly  Pro Ser Val 

    1295                 1300                 1305             





Phe Leu  Phe Pro Pro Lys Pro  Lys Asp Thr Leu Met  Ile Ser Arg 

    1310                 1315                 1320             





Thr Pro  Glu Val Thr Cys Val  Val Val Asp Val Ser  His Glu Asp 

    1325                 1330                 1335             





Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp Gly Val  Glu Val His 

    1340                 1345                 1350             





Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 

    1355                 1360                 1365             





Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 

    1370                 1375                 1380             





Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 

    1385                 1390                 1395             





Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 

    1400                 1405                 1410             





Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Asp Glu  Leu Thr Lys 

    1415                 1420                 1425             





Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 

    1430                 1435                 1440             





Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 

    1445                 1450                 1455             





Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 

    1460                 1465                 1470             





Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 

    1475                 1480                 1485             





Asn Val  Phe Ser Cys Ser Val  Met His Glu Ala Leu  His Asn His 

    1490                 1495                 1500             





Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  

    1505                 1510                 1515 





<210>  119

<211>  1778

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN VWF 034 protein sequence



<400>  119



Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 

1               5                   10                  15      





Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 

            20                  25                  30          





Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 

        35                  40                  45              





Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 

    50                  55                  60                  





Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 

65                  70                  75                  80  





Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 

                85                  90                  95      





Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 

            100                 105                 110         





Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 

        115                 120                 125             





Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 

    130                 135                 140                 





Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 

145                 150                 155                 160 





Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 

                165                 170                 175     





Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 

            180                 185                 190         





Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 

        195                 200                 205             





Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 

    210                 215                 220                 





Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 

225                 230                 235                 240 





Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 

                245                 250                 255     





Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 

            260                 265                 270         





Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 

        275                 280                 285             





Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 

    290                 295                 300                 





Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 

305                 310                 315                 320 





Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 

                325                 330                 335     





Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 

            340                 345                 350         





Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 

        355                 360                 365             





Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 

    370                 375                 380                 





Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 

385                 390                 395                 400 





Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 

                405                 410                 415     





Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 

            420                 425                 430         





Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 

        435                 440                 445             





Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 

    450                 455                 460                 





Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 

465                 470                 475                 480 





Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 

                485                 490                 495     





Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 

            500                 505                 510         





Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 

        515                 520                 525             





Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 

    530                 535                 540                 





Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 

545                 550                 555                 560 





Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 

                565                 570                 575     





Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 

            580                 585                 590         





Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 

        595                 600                 605             





Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 

    610                 615                 620                 





Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 

625                 630                 635                 640 





Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 

                645                 650                 655     





Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 

            660                 665                 670         





Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 

        675                 680                 685             





Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 

    690                 695                 700                 





Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 

705                 710                 715                 720 





Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 

                725                 730                 735     





His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 

            740                 745                 750         





Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 

        755                 760                 765             





Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 

    770                 775                 780                 





Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 

785                 790                 795                 800 





Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 

                805                 810                 815     





His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 

            820                 825                 830         





Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 

        835                 840                 845             





Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 

    850                 855                 860                 





Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 

865                 870                 875                 880 





Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 

                885                 890                 895     





Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 

            900                 905                 910         





Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 

        915                 920                 925             





Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 

    930                 935                 940                 





Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 

945                 950                 955                 960 





Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 

                965                 970                 975     





His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 

            980                 985                 990         





Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 

        995                 1000                 1005             





Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 

    1010                 1015                 1020             





Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 

    1025                 1030                 1035             





Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 

    1040                 1045                 1050             





Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 

    1055                 1060                 1065             





Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 

    1070                 1075                 1080             





Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 

    1085                 1090                 1095             





Ala Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 

    1100                 1105                 1110             





His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 

    1115                 1120                 1125             





Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Ala Glu 

    1130                 1135                 1140             





Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 

    1145                 1150                 1155             





His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 

    1160                 1165                 1170             





His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 

    1175                 1180                 1185             





Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 

    1190                 1195                 1200             





Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 

    1205                 1210                 1215             





Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 

    1220                 1225                 1230             





Cys Glu  Ala Cys Gln Glu Pro  Ile Ser Gly Thr Ser  Glu Ser Ala 

    1235                 1240                 1245             





Thr Pro  Glu Ser Gly Pro Gly  Ser Glu Pro Ala Thr  Ser Gly Ser 

    1250                 1255                 1260             





Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro 

    1265                 1270                 1275             





Gly Ser  Glu Pro Ala Thr Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 

    1280                 1285                 1290             





Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly Thr Ser  Thr Glu Pro 

    1295                 1300                 1305             





Ser Glu  Gly Ser Ala Pro Gly  Ser Pro Ala Gly Ser  Pro Thr Ser 

    1310                 1315                 1320             





Thr Glu  Glu Gly Thr Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro 

    1325                 1330                 1335             





Gly Ser  Glu Pro Ala Thr Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 

    1340                 1345                 1350             





Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly Ser Pro  Ala Gly Ser 

    1355                 1360                 1365             





Pro Thr  Ser Thr Glu Glu Gly  Ser Pro Ala Gly Ser  Pro Thr Ser 

    1370                 1375                 1380             





Thr Glu  Glu Gly Thr Ser Thr  Glu Pro Ser Glu Gly  Ser Ala Pro 

    1385                 1390                 1395             





Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Gly Pro  Gly Thr Ser 

    1400                 1405                 1410             





Glu Ser  Ala Thr Pro Glu Ser  Gly Pro Gly Thr Ser  Glu Ser Ala 

    1415                 1420                 1425             





Thr Pro  Glu Ser Gly Pro Gly  Ser Glu Pro Ala Thr  Ser Gly Ser 

    1430                 1435                 1440             





Glu Thr  Pro Gly Ser Glu Pro  Ala Thr Ser Gly Ser  Glu Thr Pro 

    1445                 1450                 1455             





Gly Ser  Pro Ala Gly Ser Pro  Thr Ser Thr Glu Glu  Gly Thr Ser 

    1460                 1465                 1470             





Thr Glu  Pro Ser Glu Gly Ser  Ala Pro Gly Thr Ser  Thr Glu Pro 

    1475                 1480                 1485             





Ser Glu  Gly Ser Ala Pro Gly  Ser Glu Pro Ala Thr  Ser Gly Ser 

    1490                 1495                 1500             





Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr Pro Glu  Ser Gly Pro 

    1505                 1510                 1515             





Gly Thr  Ser Thr Glu Pro Ser  Glu Gly Ser Ala Pro  Asp Ile Gly 

    1520                 1525                 1530             





Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Leu Val  Pro Arg Gly 

    1535                 1540                 1545             





Ser Gly  Gly Asp Lys Thr His  Thr Cys Pro Pro Cys  Pro Ala Pro 

    1550                 1555                 1560             





Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu Phe Pro  Pro Lys Pro 

    1565                 1570                 1575             





Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro Glu Val  Thr Cys Val 

    1580                 1585                 1590             





Val Val  Asp Val Ser His Glu  Asp Pro Glu Val Lys  Phe Asn Trp 

    1595                 1600                 1605             





Tyr Val  Asp Gly Val Glu Val  His Asn Ala Lys Thr  Lys Pro Arg 

    1610                 1615                 1620             





Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val Val Ser  Val Leu Thr 

    1625                 1630                 1635             





Val Leu  His Gln Asp Trp Leu  Asn Gly Lys Glu Tyr  Lys Cys Lys 

    1640                 1645                 1650             





Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile Glu Lys  Thr Ile Ser 

    1655                 1660                 1665             





Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln Val Tyr  Thr Leu Pro 

    1670                 1675                 1680             





Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln Val Ser  Leu Thr Cys 

    1685                 1690                 1695             





Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu 

    1700                 1705                 1710             





Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val 

    1715                 1720                 1725             





Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val 

    1730                 1735                 1740             





Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val 

    1745                 1750                 1755             





Met His  Glu Ala Leu His Asn  His Tyr Thr Gln Lys  Ser Leu Ser 

    1760                 1765                 1770             





Leu Ser  Pro Gly Lys 

    1775             





<210>  120

<211>  1565

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN VWF 036  protein sequence



<400>  120



Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 

1               5                   10                  15      





Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 

            20                  25                  30          





Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 

        35                  40                  45              





Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 

    50                  55                  60                  





Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 

65                  70                  75                  80  





Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 

                85                  90                  95      





Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 

            100                 105                 110         





Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 

        115                 120                 125             





Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 

    130                 135                 140                 





Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 

145                 150                 155                 160 





Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 

                165                 170                 175     





Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 

            180                 185                 190         





Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 

        195                 200                 205             





Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 

    210                 215                 220                 





Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 

225                 230                 235                 240 





Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 

                245                 250                 255     





Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 

            260                 265                 270         





Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 

        275                 280                 285             





Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 

    290                 295                 300                 





Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 

305                 310                 315                 320 





Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 

                325                 330                 335     





Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 

            340                 345                 350         





Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 

        355                 360                 365             





Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 

    370                 375                 380                 





Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 

385                 390                 395                 400 





Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 

                405                 410                 415     





Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 

            420                 425                 430         





Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 

        435                 440                 445             





Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 

    450                 455                 460                 





Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 

465                 470                 475                 480 





Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 

                485                 490                 495     





Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 

            500                 505                 510         





Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 

        515                 520                 525             





Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 

    530                 535                 540                 





Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 

545                 550                 555                 560 





Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 

                565                 570                 575     





Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 

            580                 585                 590         





Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 

        595                 600                 605             





Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 

    610                 615                 620                 





Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 

625                 630                 635                 640 





Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 

                645                 650                 655     





Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 

            660                 665                 670         





Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 

        675                 680                 685             





Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 

    690                 695                 700                 





Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 

705                 710                 715                 720 





Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 

                725                 730                 735     





His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 

            740                 745                 750         





Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 

        755                 760                 765             





Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 

    770                 775                 780                 





Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 

785                 790                 795                 800 





Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 

                805                 810                 815     





His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 

            820                 825                 830         





Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 

        835                 840                 845             





Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 

    850                 855                 860                 





Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 

865                 870                 875                 880 





Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 

                885                 890                 895     





Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 

            900                 905                 910         





Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 

        915                 920                 925             





Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 

    930                 935                 940                 





Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 

945                 950                 955                 960 





Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 

                965                 970                 975     





His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 

            980                 985                 990         





Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 

        995                 1000                 1005             





Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 

    1010                 1015                 1020             





Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 

    1025                 1030                 1035             





Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 

    1040                 1045                 1050             





Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 

    1055                 1060                 1065             





Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 

    1070                 1075                 1080             





Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 

    1085                 1090                 1095             





Ala Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 

    1100                 1105                 1110             





His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 

    1115                 1120                 1125             





Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Ala Glu 

    1130                 1135                 1140             





Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 

    1145                 1150                 1155             





His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 

    1160                 1165                 1170             





His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 

    1175                 1180                 1185             





Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 

    1190                 1195                 1200             





Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 

    1205                 1210                 1215             





Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 

    1220                 1225                 1230             





Cys Glu  Ala Cys Gln Glu Pro  Ile Ser Gly Gly Gly  Gly Ser Gly 

    1235                 1240                 1245             





Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 

    1250                 1255                 1260             





Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 

    1265                 1270                 1275             





Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 

    1280                 1285                 1290             





Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 

    1295                 1300                 1305             





Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Leu 

    1310                 1315                 1320             





Val Pro  Arg Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 

    1325                 1330                 1335             





Asp Lys  Thr His Thr Cys Pro  Pro Cys Pro Ala Pro  Glu Leu Leu 

    1340                 1345                 1350             





Gly Gly  Pro Ser Val Phe Leu  Phe Pro Pro Lys Pro  Lys Asp Thr 

    1355                 1360                 1365             





Leu Met  Ile Ser Arg Thr Pro  Glu Val Thr Cys Val  Val Val Asp 

    1370                 1375                 1380             





Val Ser  His Glu Asp Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp 

    1385                 1390                 1395             





Gly Val  Glu Val His Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln 

    1400                 1405                 1410             





Tyr Asn  Ser Thr Tyr Arg Val  Val Ser Val Leu Thr  Val Leu His 

    1415                 1420                 1425             





Gln Asp  Trp Leu Asn Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn 

    1430                 1435                 1440             





Lys Ala  Leu Pro Ala Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys 

    1445                 1450                 1455             





Gly Gln  Pro Arg Glu Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg 

    1460                 1465                 1470             





Asp Glu  Leu Thr Lys Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys 

    1475                 1480                 1485             





Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly 

    1490                 1495                 1500             





Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser 

    1505                 1510                 1515             





Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser 

    1520                 1525                 1530             





Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys Ser Val  Met His Glu 

    1535                 1540                 1545             





Ala Leu  His Asn His Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro 

    1550                 1555                 1560             





Gly Lys  

    1565 





<210>  121

<211>  247

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYN Fc-015  protein sequence



<400>  121



Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 

1               5                   10                  15      





Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 

            20                  25                  30          





Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 

        35                  40                  45              





Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 

    50                  55                  60                  





Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 

65                  70                  75                  80  





Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 

                85                  90                  95      





Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 

            100                 105                 110         





Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 

        115                 120                 125             





Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 

    130                 135                 140                 





Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 

145                 150                 155                 160 





Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 

                165                 170                 175     





Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 

            180                 185                 190         





Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 

        195                 200                 205             





Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 

    210                 215                 220                 





Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 

225                 230                 235                 240 





Leu Ser Leu Ser Pro Gly Lys 

                245         





<210>  122

<211>  33

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  polypeptide



<400>  122



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 

1               5                   10                  15      





Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly 

            20                  25                  30          





Gly 

    





<210>  123

<211>  1240

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  VWF-D1D2D'D3



<400>  123



Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 

1               5                   10                  15      





Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 

            20                  25                  30          





Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 

        35                  40                  45              





Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 

    50                  55                  60                  





Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 

65                  70                  75                  80  





Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 

                85                  90                  95      





Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 

            100                 105                 110         





Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 

        115                 120                 125             





Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 

    130                 135                 140                 





Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 

145                 150                 155                 160 





Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 

                165                 170                 175     





Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 

            180                 185                 190         





Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 

        195                 200                 205             





Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 

    210                 215                 220                 





Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 

225                 230                 235                 240 





Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 

                245                 250                 255     





Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 

            260                 265                 270         





Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 

        275                 280                 285             





Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 

    290                 295                 300                 





Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 

305                 310                 315                 320 





Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 

                325                 330                 335     





Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 

            340                 345                 350         





Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 

        355                 360                 365             





Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 

    370                 375                 380                 





Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 

385                 390                 395                 400 





Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 

                405                 410                 415     





Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 

            420                 425                 430         





Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 

        435                 440                 445             





Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 

    450                 455                 460                 





Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 

465                 470                 475                 480 





Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 

                485                 490                 495     





Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 

            500                 505                 510         





Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 

        515                 520                 525             





Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 

    530                 535                 540                 





Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 

545                 550                 555                 560 





Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 

                565                 570                 575     





Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 

            580                 585                 590         





Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 

        595                 600                 605             





Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 

    610                 615                 620                 





Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 

625                 630                 635                 640 





Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 

                645                 650                 655     





Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 

            660                 665                 670         





Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 

        675                 680                 685             





Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 

    690                 695                 700                 





Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 

705                 710                 715                 720 





Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 

                725                 730                 735     





His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 

            740                 745                 750         





Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 

        755                 760                 765             





Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 

    770                 775                 780                 





Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 

785                 790                 795                 800 





Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 

                805                 810                 815     





His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 

            820                 825                 830         





Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 

        835                 840                 845             





Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 

    850                 855                 860                 





Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 

865                 870                 875                 880 





Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 

                885                 890                 895     





Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 

            900                 905                 910         





Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 

        915                 920                 925             





Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 

    930                 935                 940                 





Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 

945                 950                 955                 960 





Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 

                965                 970                 975     





His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 

            980                 985                 990         





Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 

        995                 1000                 1005             





Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 

    1010                 1015                 1020             





Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 

    1025                 1030                 1035             





Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 

    1040                 1045                 1050             





Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 

    1055                 1060                 1065             





Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 

    1070                 1075                 1080             





Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 

    1085                 1090                 1095             





Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 

    1100                 1105                 1110             





His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 

    1115                 1120                 1125             





Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 

    1130                 1135                 1140             





Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 

    1145                 1150                 1155             





His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 

    1160                 1165                 1170             





His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 

    1175                 1180                 1185             





Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 

    1190                 1195                 1200             





Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 

    1205                 1210                 1215             





Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 

    1220                 1225                 1230             





Cys Glu  Ala Cys Gln Glu Pro  

    1235                 1240 





<210>  124

<211>  477

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  VWF-D'D3



<400>  124



Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 

1               5                   10                  15      





Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 

            20                  25                  30          





Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 

        35                  40                  45              





Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 

    50                  55                  60                  





Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 

65                  70                  75                  80  





Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 

                85                  90                  95      





Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr 

            100                 105                 110         





Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr 

        115                 120                 125             





Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile 

    130                 135                 140                 





Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys 

145                 150                 155                 160 





Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly 

                165                 170                 175     





Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu Val 

            180                 185                 190         





Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser 

        195                 200                 205             





Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln Thr 

    210                 215                 220                 





Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln 

225                 230                 235                 240 





Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val 

                245                 250                 255     





Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg 

            260                 265                 270         





Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met 

        275                 280                 285             





Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val 

    290                 295                 300                 





Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val 

305                 310                 315                 320 





Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys 

                325                 330                 335     





Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly 

            340                 345                 350         





Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu 

        355                 360                 365             





Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn 

    370                 375                 380                 





Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu 

385                 390                 395                 400 





Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro Pro 

                405                 410                 415     





Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp 

            420                 425                 430         





Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys 

        435                 440                 445             





Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His Cys 

    450                 455                 460                 





Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro 

465                 470                 475         





<210>  125

<211>  5055

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  pSYNFVIII 010



<400>  125

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60



accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120



ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180



acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240



gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300



gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360



ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420



gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480



aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540



gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600



gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660



tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720



gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780



ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840



accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900



cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960



gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020



gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080



gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140



gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200



tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260



cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320



aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380



attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440



ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500



gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560



ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620



actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680



gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740



agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800



aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860



cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920



tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980



attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040



atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100



atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160



atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220



agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280



ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt     2340



cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa     2400



gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca     2460



cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca     2520



catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc     2580



caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat     2640



ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc     2700



agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat     2760



cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac     2820



ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg     2880



gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt     2940



ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa     3000



tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg     3060



gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat     3120



tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct     3180



caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct     3240



attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg     3300



tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt     3360



tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg     3420



gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt     3480



cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat     3540



tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg     3600



ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc     3660



ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat     3720



cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata     3780



aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat     3840



tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc     3900



atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac     3960



tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg     4020



agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag     4080



aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg     4140



tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt     4200



cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac     4260



tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac     4320



cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta cgacaaaact     4380



cacacatgcc caccgtgccc agctccagaa ctcctgggcg gaccgtcagt cttcctcttc     4440



cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     4500



gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     4560



gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     4620



agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     4680



tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     4740



cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     4800



agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     4860



aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgttggactc cgacggctcc     4920



ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     4980



tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     5040



tctccgggta aatga                                                      5055





<210>  126

<211>  1684

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  pSYNFVIII 010



<400>  126



Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 

1               5                   10                  15      





Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 

            20                  25                  30          





Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 

        35                  40                  45              





Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 

    50                  55                  60                  





Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 

65                  70                  75                  80  





Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 

                85                  90                  95      





Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 

            100                 105                 110         





His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 

        115                 120                 125             





Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 

    130                 135                 140                 





Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 

145                 150                 155                 160 





Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 

                165                 170                 175     





Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 

            180                 185                 190         





Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 

        195                 200                 205             





Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 

    210                 215                 220                 





Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 

225                 230                 235                 240 





Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 

                245                 250                 255     





Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 

            260                 265                 270         





Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 

        275                 280                 285             





Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 

    290                 295                 300                 





Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 

305                 310                 315                 320 





Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 

                325                 330                 335     





Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 

            340                 345                 350         





Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 

        355                 360                 365             





Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 

    370                 375                 380                 





Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 

385                 390                 395                 400 





Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 

                405                 410                 415     





Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 

            420                 425                 430         





Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 

        435                 440                 445             





Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 

    450                 455                 460                 





Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 

465                 470                 475                 480 





Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 

                485                 490                 495     





His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 

            500                 505                 510         





Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 

        515                 520                 525             





Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 

    530                 535                 540                 





Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 

545                 550                 555                 560 





Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 

                565                 570                 575     





Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 

            580                 585                 590         





Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 

        595                 600                 605             





Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 

    610                 615                 620                 





Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 

625                 630                 635                 640 





Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 

                645                 650                 655     





Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 

            660                 665                 670         





Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 

        675                 680                 685             





Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 

    690                 695                 700                 





Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 

705                 710                 715                 720 





Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 

                725                 730                 735     





Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 

            740                 745                 750         





Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 

        755                 760                 765             





Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 

    770                 775                 780                 





Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 

785                 790                 795                 800 





Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 

                805                 810                 815     





Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 

            820                 825                 830         





Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 

        835                 840                 845             





Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 

    850                 855                 860                 





Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 

865                 870                 875                 880 





Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 

                885                 890                 895     





Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 

            900                 905                 910         





Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 

        915                 920                 925             





Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 

    930                 935                 940                 





Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 

945                 950                 955                 960 





Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 

                965                 970                 975     





Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 

            980                 985                 990         





Gly Arg Gln Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 

        995                 1000                 1005             





Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 

    1010                 1015                 1020             





Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 

    1025                 1030                 1035             





Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 

    1040                 1045                 1050             





Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 

    1055                 1060                 1065             





Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 

    1070                 1075                 1080             





Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 

    1085                 1090                 1095             





Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 

    1100                 1105                 1110             





Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 

    1115                 1120                 1125             





Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 

    1130                 1135                 1140             





Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 

    1145                 1150                 1155             





Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 

    1160                 1165                 1170             





Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 

    1175                 1180                 1185             





Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 

    1190                 1195                 1200             





Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 

    1205                 1210                 1215             





Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 

    1220                 1225                 1230             





Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 

    1235                 1240                 1245             





Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 

    1250                 1255                 1260             





Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 

    1265                 1270                 1275             





Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 

    1280                 1285                 1290             





Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 

    1295                 1300                 1305             





Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 

    1310                 1315                 1320             





Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 

    1325                 1330                 1335             





Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 

    1340                 1345                 1350             





Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 

    1355                 1360                 1365             





Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 

    1370                 1375                 1380             





Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 

    1385                 1390                 1395             





Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 

    1400                 1405                 1410             





Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 

    1415                 1420                 1425             





Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 

    1430                 1435                 1440             





Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Asp 

    1445                 1450                 1455             





Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 

    1460                 1465                 1470             





Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 

    1475                 1480                 1485             





Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 

    1490                 1495                 1500             





Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 

    1505                 1510                 1515             





Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 

    1520                 1525                 1530             





Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 

    1535                 1540                 1545             





Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 

    1550                 1555                 1560             





Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 

    1565                 1570                 1575             





Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 

    1580                 1585                 1590             





Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 

    1595                 1600                 1605             





Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 

    1610                 1615                 1620             





Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 

    1625                 1630                 1635             





Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 

    1640                 1645                 1650             





Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 

    1655                 1660                 1665             





Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 

    1670                 1675                 1680             





Lys 

    





<210>  127

<211>  78

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE72 XTEN



<400>  127



Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 

1               5                   10                  15      





Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 

            20                  25                  30          





Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 

        35                  40                  45              





Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 

    50                  55                  60                  





Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Ser Ser 

65                  70                  75              





<210>  128

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE144_2A



<400>  128



Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 

1               5                   10                  15      





Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 

            20                  25                  30          





Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

        35                  40                  45              





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 

    50                  55                  60                  





Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

65                  70                  75                  80  





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

                85                  90                  95      





Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 

            100                 105                 110         





Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

        115                 120                 125             





Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

    130                 135                 140                 





<210>  129

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE144_3B



<400>  129



Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 

1               5                   10                  15      





Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 

            20                  25                  30          





Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

        35                  40                  45              





Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 

    50                  55                  60                  





Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 

65                  70                  75                  80  





Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

                85                  90                  95      





Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 

            100                 105                 110         





Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

        115                 120                 125             





Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

    130                 135                 140                 





<210>  130

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE144_4A



<400>  130



Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

1               5                   10                  15      





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

            20                  25                  30          





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

        35                  40                  45              





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 

    50                  55                  60                  





Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

65                  70                  75                  80  





Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 

                85                  90                  95      





Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 

            100                 105                 110         





Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 

        115                 120                 125             





Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

    130                 135                 140                 





<210>  131

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE144_5A



<400>  131



Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 

1               5                   10                  15      





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

            20                  25                  30          





Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 

        35                  40                  45              





Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 

    50                  55                  60                  





Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

65                  70                  75                  80  





Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

                85                  90                  95      





Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 

            100                 105                 110         





Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

        115                 120                 125             





Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 

    130                 135                 140                 





<210>  132

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE144_6B



<400>  132



Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 

1               5                   10                  15      





Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

            20                  25                  30          





Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 

        35                  40                  45              





Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 

    50                  55                  60                  





Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 

65                  70                  75                  80  





Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

                85                  90                  95      





Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 

            100                 105                 110         





Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 

        115                 120                 125             





Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 

    130                 135                 140                 





<210>  133

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AG144_A



<400>  133



Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 

1               5                   10                  15      





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 

            20                  25                  30          





Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 

        35                  40                  45              





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 

    50                  55                  60                  





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

65                  70                  75                  80  





Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 

                85                  90                  95      





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 

            100                 105                 110         





Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

        115                 120                 125             





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

    130                 135                 140                 





<210>  134

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AG144_B



<400>  134



Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

1               5                   10                  15      





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

            20                  25                  30          





Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 

        35                  40                  45              





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 

    50                  55                  60                  





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 

65                  70                  75                  80  





Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 

                85                  90                  95      





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 

            100                 105                 110         





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

        115                 120                 125             





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

    130                 135                 140                 





<210>  135

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AG144_C



<400>  135



Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 

1               5                   10                  15      





Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

            20                  25                  30          





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

        35                  40                  45              





Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 

    50                  55                  60                  





Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 

65                  70                  75                  80  





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

                85                  90                  95      





Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 

            100                 105                 110         





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

        115                 120                 125             





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

    130                 135                 140                 





<210>  136

<211>  144

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AG144_F



<400>  136



Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 

1               5                   10                  15      





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

            20                  25                  30          





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

        35                  40                  45              





Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 

    50                  55                  60                  





Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 

65                  70                  75                  80  





Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 

                85                  90                  95      





Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 

            100                 105                 110         





Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 

        115                 120                 125             





Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 

    130                 135                 140                 





<210>  137

<211>  288

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  AE288_2



<400>  137



Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 

1               5                   10                  15      





Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 

            20                  25                  30          





Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 

        35                  40                  45              





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

    50                  55                  60                  





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 

65                  70                  75                  80  





Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

                85                  90                  95      





Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 

            100                 105                 110         





Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 

        115                 120                 125             





Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

    130                 135                 140                 





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 

145                 150                 155                 160 





Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 

                165                 170                 175     





Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 

            180                 185                 190         





Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 

        195                 200                 205             





Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 

    210                 215                 220                 





Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 

225                 230                 235                 240 





Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 

                245                 250                 255     





Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 

            260                 265                 270         





Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 

        275                 280                 285             





<210>  138

<211>  20

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker



<400>  138



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 

1               5                   10                  15      





Gly Gly Gly Ser 

            20  





<210>  139

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker





<220>

<221>  REPEAT

<222>  (1)..(5)

<223>  May be repeated 1 to 10 times



<400>  139



Gly Gly Gly Gly Ser 

1               5   





<210>  140

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  linker





<220>

<221>  REPEAT

<222>  (2)..(6)

<223>  May be repeated 1 to 10 times



<400>  140



Ser Gly Gly Gly Gly Ser 

1               5       





