                         SEQUENCE LISTING

<110>  UAB Research Foundation
       Walter, Mark R.
 
<120>  Compositions and Methods for Modulation of IL-20 Family Cytokine 
       Activity

<130>  35979-879792

<150>  US 61/669935
<151>  2012-07-12

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
1               5                   10                  15      


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
            20                  25                  30          


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
        35                  40                  45              


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
    50                  55                  60                  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
65                  70                  75                  80  


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
                85                  90                  95      


Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His 
            100                 105                 110         


Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr 
        115                 120                 125             


Asp Gln Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu 
    130                 135                 140                 


Asp Val Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Phe Ser 
145                 150                 155                 160 


Ala 
    


<210>  2
<211>  486
<212>  DNA
<213>  Homo sapiens

<400>  2
atggcctcag tagacaacca cggtctcagg agatgtctga tttccacaga catgcaccat       60

atagaagaga gtttccaaga aatcaaaaga gccatccaag ctaaggacac cttcccaaat      120

gtcactatcc tgtccacatt ggagactctg cagatcatta agcccttaga tgtgtgctgc      180

gtgaccaaga acctcctggc gttctacgtg gacagggtgt tcaaggatca tcaggagcca      240

aaccccaaaa tcttgagaaa aatcagcagc attgccaact ctttcctcta catgcagaaa      300

actctgcggc aatgtcaaga acagaggcag tgtcactgca ggcaggaagc caccaatgcc      360

accagagtca tccatgacaa ctatgatcag ctggaggtcc acgctgctgc cattaaatcc      420

ctgggagagc tcgacgtctt tctagcctgg attaataaga atcatgaagt aatgttctca      480

gcttga                                                                 486


<210>  3
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala Thr Asn Leu 
1               5                   10                  15      


Gln Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val Gln Ala 
            20                  25                  30          


Lys Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu Ser Leu 
        35                  40                  45              


Gln Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His Leu Leu 
    50                  55                  60                  


Arg Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro Asp His 
65                  70                  75                  80  


Tyr Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu Thr Ile 
                85                  90                  95      


Lys Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys His Cys Gly 
            100                 105                 110         


Glu Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe Glu Lys 
        115                 120                 125             


Leu Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp Ile 
    130                 135                 140                 


Leu Leu Gln Trp Met Glu Glu Thr Glu 
145                 150             


<210>  4
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  4
atgctgaaga cactcaattt gggaagctgt gtgatcgcca caaaccttca ggaaatacga       60

aatggatttt ctgagatacg gggcagtgtg caagccaaag atggaaacat tgacatcaga      120

atcttaagga ggactgagtc tttgcaagac acaaagcctg cgaatcgatg ctgcctcctg      180

cgccatttgc taagactcta tctggacagg gtatttaaaa actaccagac ccctgaccat      240

tatactctcc ggaagatcag cagcctcgcc aattcctttc ttaccatcaa gaaggacctc      300

cggctctgtc atgcccacat gacatgccat tgtggggagg aagcaatgaa gaaatacagc      360

cagattctga gtcactttga aaagctggaa cctcaggcag cagttgtgaa ggctttgggg      420

gaactagaca ttcttctgca atggatggag gagacagaat ag                         462


<210>  5
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Pro Cys Val Ser Gly Gly Leu Pro Lys Pro Ala Asn Ile Thr Phe 
1               5                   10                  15      


Leu Ser Ile Asn Met Lys Asn Val Leu Gln Trp Thr Pro Pro Glu Gly 
            20                  25                  30          


Leu Gln Gly Val Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly 
        35                  40                  45              


Gln Lys Lys Trp Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr 
    50                  55                  60                  


Tyr Cys Asp Leu Ser Ala Glu Thr Ser Asp Tyr Glu His Gln Tyr Tyr 
65                  70                  75                  80  


Ala Lys Val Lys Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu 
                85                  90                  95      


Ser Gly Arg Phe Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu 
            100                 105                 110         


Val Ala Leu Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala 
        115                 120                 125             


Pro Glu Lys Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln 
    130                 135                 140                 


Gln Ile Tyr Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys 
145                 150                 155                 160 


Ser Asn Arg Thr Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu 
                165                 170                 175     


Thr Trp Leu Glu Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe 
            180                 185                 190         


Val Pro Gly Pro Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala 
        195                 200                 205             


Arg Thr Leu Lys Asp Gln Ser Ser 
    210                 215     


<210>  6
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  6
gttccctgtg tctctggtgg tttgcctaaa cctgcaaaca tcaccttctt atccatcaac       60

atgaagaatg tcctacaatg gactccacca gagggtcttc aaggagttaa agttacttac      120

actgtgcagt atttcatata tgggcaaaag aaatggctga ataaatcaga atgcagaaat      180

atcaatagaa cctactgtga tctttctgct gaaacttctg actacgaaca ccagtattat      240

gccaaagtta aggccatttg gggaacaaag tgttccaaat gggctgaaag tggacggttc      300

tatccttttt tagaaacaca aattggccca ccagaggtgg cactgactac agatgagaag      360

tccatttctg ttgtcctgac agctccagag aagtggaaga gaaatccaga agaccttcct      420

gtttccatgc aacaaatata ctccaatctg aagtataacg tgtctgtgtt gaatactaaa      480

tcaaacagaa cgtggtccca gtgtgtgacc aaccacacgc tggtgctcac ctggctggag      540

ccgaacactc tttactgcgt acacgtggag tccttcgtcc cagggccccc tcgccgtgct      600

cagccttctg agaagcagtg tgccaggact ttgaaagatc aatcatcaat tgaaggtaga      660

ctcgagtcta gagggccctt cgaaggtaag cctatcccta accctctcct cggtctcgat      720

tctacgcgta ccggtcatca tcaccatcac cattga                                756


<210>  7
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Glu Val Ala Ile Leu Pro Ala Pro Gln Gln Leu Ser Val Leu Ser 
1               5                   10                  15      


Thr Asn Met Lys His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly 
            20                  25                  30          


Glu Thr Val Tyr Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu 
        35                  40                  45              


Tyr Thr Ser His Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu 
    50                  55                  60                  


Gly Pro Glu Cys Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr 
65                  70                  75                  80  


Asn Leu Arg Val Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser 
                85                  90                  95      


Ile Leu Lys His Pro Phe Asn Arg Gln Ser Thr Ile Leu Thr Arg Pro 
            100                 105                 110         


Gly Met Glu Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu 
        115                 120                 125             


Asp Leu Gly Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu 
    130                 135                 140                 


Pro Gly Ala Glu Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro 
145                 150                 155                 160 


Val His Leu Glu Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala 
                165                 170                 175     


Gln Thr Phe Val Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr 
            180                 185                 190         


Glu Cys Val Glu Val Gln Gly Glu Ala 
        195                 200     


<210>  8
<211>  710
<212>  DNA
<213>  Homo sapiens

<400>  8
gatgaagtgg ccattctgcc tgcccctcag cagctctctg tactctcaac caacatgaag       60

catctcttga tgtggagccc agtgatcgcg cctggagaaa cagtgtacta ttctgtcgaa      120

taccaggggg agtacgagag cctgtacacg agccacatct ggatccccag cagctggtgc      180

tcactcactg aaggtcctga gtgtgatgtc actgatgaca tcacggccac tgtgccatac      240

aaccttcgtg tcagggccac attgggctca cagacctcag cctggagcat cctgaagcat      300

ccctttaata gaaactcaac catccttacc cgacctggga tggagatcac caaagatggc      360

ttccacctgg ttattgagct ggaggacctg gggccccagt ttgagttcct tgtggcctac      420

tggaggaggg agcctggtgc cgaggaacat gtcaaaatgg tgaggagtgg gggtattcca      480

gtgcacctag aaaccatgga gccaggggct gcatactgtg tgaaggccca gacattcgtg      540

aaggccattg ggaggtacag cgccttcagc cagacagaat gtgtggaggt gcaaggagag      600

gccattgaag gtagactcga gtctagaggg cccttcgaag gtaagcctat ccctaaccct      660

ctcctcggtc tcgattctac gcgtaccggt catcatcacc atcaccattg                 710


<210>  9
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  9

His Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln 
1               5                   10                  15      


Ser Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly 
            20                  25                  30          


Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg 
        35                  40                  45              


Asp Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys 
    50                  55                  60                  


Asp Leu Thr Val Glu Thr Gly Asp Leu Gln Glu Leu Tyr Tyr Ala Arg 
65                  70                  75                  80  


Val Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp 
                85                  90                  95      


Arg Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr 
            100                 105                 110         


Cys Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro 
        115                 120                 125             


Thr Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile 
    130                 135                 140                 


Phe His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr 
145                 150                 155                 160 


Gln Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu 
                165                 170                 175     


Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr 
            180                 185                 190         


Trp Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro 
        195                 200                 205             


Asp Arg Thr 
    210     


<210>  10
<211>  741
<212>  DNA
<213>  Homo sapiens

<400>  10
cacgcccctg aggacccctc ggatctgctc cagcacgtga aattccagtc cagcaacttt       60

gaaaacatcc tgacgtggga cagcgggcca gagggcaccc cagacacggt ctacagcatc      120

gagtataaga cgtacggaga gagggactgg gtggcaaaga agggctgtca gcggatcacc      180

cggaagtcct gcgacctgac ggtggagacg ggcgacctcc aggagctcta ctatgccagg      240

gtcaccgctg tcagtgcggg aggccggtca gccaccaaga tgactgacag gttcagctct      300

ctgcagcaca ctaccctcaa gccacctgat gtgacctgta tctccaaagt gagatcgatt      360

cagatgattg ttcatcctac ccccacgcca atccgtgcag gcgatggcca ccggctaacc      420

ctggaagaca tcttccatga cctgttctac cacttagagc tccaggtcaa ccgcacctac      480

caaatgcacc ttggagggaa gcagagagaa tatgagttct tcggcctgac ccctgacaca      540

gagttccttg gcaccatcat gatttgcgtt cccacctggg ccaaggagag tgccccctac      600

atgtgccgag tgaagacact gccagaccgg acaattgaag gtagagtcga gtctagaggg      660

cccttcgaag gtaagcctat ccctaaccct ctcctcggtc tcgattctac gcgtaccggt      720

catcatcacc atcaccattg a                                                741


<210>  11
<211>  467
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11

Val Pro Cys Val Ser Gly Gly Leu Pro Lys Pro Ala Asn Ile Thr Phe 
1               5                   10                  15      


Leu Ser Ile Asn Met Lys Asn Val Leu Gln Trp Thr Pro Pro Glu Gly 
            20                  25                  30          


Leu Gln Gly Val Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly 
        35                  40                  45              


Gln Lys Lys Trp Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr 
    50                  55                  60                  


Tyr Cys Asp Leu Ser Ala Glu Thr Ser Asp Tyr Glu His Gln Tyr Tyr 
65                  70                  75                  80  


Ala Lys Val Lys Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu 
                85                  90                  95      


Ser Gly Arg Phe Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu 
            100                 105                 110         


Val Ala Leu Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala 
        115                 120                 125             


Pro Glu Lys Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln 
    130                 135                 140                 


Gln Ile Tyr Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys 
145                 150                 155                 160 


Ser Asn Arg Thr Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu 
                165                 170                 175     


Thr Trp Leu Glu Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe 
            180                 185                 190         


Val Pro Gly Pro Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala 
        195                 200                 205             


Arg Thr Leu Lys Asp Gln Ser Ser Glu Phe Lys Ala Lys Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
225                 230                 235                 240 


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
                245                 250                 255     


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
            260                 265                 270         


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
        275                 280                 285             


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
    290                 295                 300                 


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
305                 310                 315                 320 


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
                325                 330                 335     


Gln Val Tyr Val Leu Pro Pro Pro Cys Glu Glu Met Thr Lys Lys Gln 
            340                 345                 350         


Val Thr Leu Tyr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
        355                 360                 365             


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
    370                 375                 380                 


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
385                 390                 395                 400 


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
                405                 410                 415     


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
            420                 425                 430         


Arg Thr Pro Gly Lys Gly Leu Glu Ala Ser Gly Gly Leu Asn Asp Ile 
        435                 440                 445             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Thr Gly His His His 
    450                 455                 460                 


His His His 
465         


<210>  12
<211>  1404
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  12
gttccctgtg tctctggtgg tttgcctaaa cctgcaaaca tcaccttctt atccatcaac       60

atgaagaatg tcctacaatg gactccacca gagggtcttc aaggagttaa agttacttac      120

actgtgcagt atttcatata tgggcaaaag aaatggctga ataaatcaga atgcagaaat      180

atcaatagaa cctactgtga tctttctgct gaaacttctg actacgaaca ccagtattat      240

gccaaagtta aggccatttg gggaacaaag tgttccaaat gggctgaaag tggacggttc      300

tatccttttt tagaaacaca aattggccca ccagaggtgg cactgactac agatgagaag      360

tccatttctg ttgtcctgac agctccagag aagtggaaga gaaatccaga agaccttcct      420

gtttccatgc aacaaatata ctccaatctg aagtataacg tgtctgtgtt gaatactaaa      480

tcaaacagaa cgtggtccca gtgtgtgacc aaccacacgc tggtgctcac ctggctggag      540

ccgaacactc tttactgcgt acacgtggag tccttcgtcc cagggccccc tcgccgtgct      600

cagccttctg agaagcagtg tgccaggact ttgaaagatc aatcatcaga gtttaaagcc      660

aaaggatccg gaggaggtgg tccatccgtc ttcatcttcc ctccaaagat caaggatgta      720

ctcatgatct ccctgagccc catagtcaca tgtgtggtgg tggatgtgag cgaggatgac      780

ccagatgtcc agatcagctg gtttgtgaac aacgtggaag tacacacagc tcagacacaa      840

acccatagag aggattacaa cagtactctc cgggtggtca gtgccctccc catccagcac      900

caggactgga tgagtggcaa ggagttcaaa tgcaaggtca acaacaaaga cctcccagcg      960

cccatcgaga gaaccatctc aaaacccaaa gggtcagtaa gagctccaca ggtatatgtc     1020

ttgcctccac catgcgaaga gatgactaag aaacaggtca ctctgtactg catggtcaca     1080

gacttcatgc ctgaagacat ttacgtggag tggaccaaca acgggaaaac agagctaaac     1140

tacaagaaca ctgaaccagt cctggactct gatggttctt acttcatgta cagcaagctg     1200

agagtggaaa agaagaactg ggtggaaaga aatagctact cctgttcagt ggtccacgag     1260

ggtctgcaca atcaccacac gactaagagc ttctcccgga ctccgggtaa aggtctcgag     1320

gctagcggag gactcaacga catcttcgaa gcacaaaaaa tcgaatggca cgaaggtacc     1380

ggtcatcatc accatcacca ttga                                            1404


<210>  13
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13

Ala His Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe 
1               5                   10                  15      


Gln Ser Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu 
            20                  25                  30          


Gly Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu 
        35                  40                  45              


Arg Asp Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser 
    50                  55                  60                  


Cys Asp Leu Thr Val Glu Thr Gly Asp Leu Gln Glu Leu Tyr Tyr Ala 
65                  70                  75                  80  


Arg Val Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr 
                85                  90                  95      


Asp Arg Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val 
            100                 105                 110         


Thr Cys Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr 
        115                 120                 125             


Pro Thr Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp 
    130                 135                 140                 


Ile Phe His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr 
145                 150                 155                 160 


Tyr Gln Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly 
                165                 170                 175     


Leu Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro 
            180                 185                 190         


Thr Trp Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu 
        195                 200                 205             


Pro Asp Arg Thr Trp Thr Tyr Ser Gly Ser Gly Gly Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
225                 230                 235                 240 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
                245                 250                 255     


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
            260                 265                 270         


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
        275                 280                 285             


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
    290                 295                 300                 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
305                 310                 315                 320 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
                325                 330                 335     


Pro Pro Pro Cys Glu Glu Met Thr Lys Lys Gln Val Thr Leu Tyr Cys 
            340                 345                 350         


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
        355                 360                 365             


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
385                 390                 395                 400 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
                405                 410                 415     


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Ala Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys 
        435                 440                 445             


Ile Glu Trp His Glu Gly Thr Gly His His His His His His 
    450                 455                 460         


<210>  14
<211>  1389
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14
gctcacgccc ctgaggaccc ctcggatctg ctccagcacg tgaaattcca gtccagcaac       60

tttgaaaaca tcctgacgtg ggacagcggg ccagagggca ccccagacac ggtctacagc      120

atcgagtata agacgtacgg agagagggac tgggtggcaa agaagggctg tcagcggatc      180

acccggaagt cctgcgacct gacggtggag acgggcgacc tccaggagct ctactatgcc      240

agggtcaccg ctgtcagtgc gggaggccgg tcagccacca agatgactga caggttcagc      300

tctctgcagc acactaccct caagccacct gatgtgacct gtatctccaa agtgagatcg      360

attcagatga ttgttcatcc tacccccacg ccaatccgtg caggcgatgg ccaccggcta      420

accctggaag acatcttcca tgacctgttc taccacttag agctccaggt caaccgcacc      480

taccaaatgc accttggagg gaagcagaga gaatatgagt tcttcggcct gacccctgac      540

acagagttcc ttggcaccat catgatttgc gttcccacct gggccaagga gagtgccccc      600

tacatgtgcc gagtgaagac actgccagac cggacatgga cctactccgg atccggagga      660

ggtggtccat ccgtcttcat cttccctcca aagatcaagg atgtactcat gatctccctg      720

agccccatag tcacatgtgt ggtggtggat gtgagcgagg atgacccaga tgtccagatc      780

agctggtttg tgaacaacgt ggaagtacac acagctcaga cacaaaccca tagagaggat      840

tacaacagta ctctccgggt ggtcagtgcc ctccccatcc agcaccagga ctggatgagt      900

ggcaaggagt tcaaatgcaa ggtcaacaac aaagacctcc cagcgcccat cgagagaacc      960

atctcaaaac ccaaagggtc agtaagagct ccacaggtat atgtcttgcc tccaccatgc     1020

gaagagatga ctaagaaaca ggtcactctg tactgcatgg tcacagactt catgcctgaa     1080

gacatttacg tggagtggac caacaacggg aaaacagagc taaactacaa gaacactgaa     1140

ccagtcctgg actctgatgg ttcttacttc atgtacagca agctgagagt ggaaaagaag     1200

aactgggtgg aaagaaatag ctactcctgt tcagtggtcc acgagggtct gcacaatcac     1260

cacacgacta agagcttctc ccggactccg ggtaaaggtc tcgaggctag cggaggactc     1320

aacgacatct tcgaagcaca aaaaatcgaa tggcacgaag gtaccggtca tcatcaccat     1380

caccattga                                                             1389


<210>  15
<211>  435
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  15

Asp Glu Val Ala Ile Leu Pro Ala Pro Gln Gln Leu Ser Val Leu Ser 
1               5                   10                  15      


Thr Asn Met Lys His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly 
            20                  25                  30          


Glu Thr Val Tyr Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu 
        35                  40                  45              


Tyr Thr Ser His Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu 
    50                  55                  60                  


Gly Pro Glu Cys Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr 
65                  70                  75                  80  


Asn Leu Arg Val Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser 
                85                  90                  95      


Ile Leu Lys His Pro Phe Asn Arg Gln Ser Thr Ile Leu Thr Arg Pro 
            100                 105                 110         


Gly Met Glu Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu 
        115                 120                 125             


Asp Leu Gly Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu 
    130                 135                 140                 


Pro Gly Ala Glu Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro 
145                 150                 155                 160 


Val His Leu Glu Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala 
                165                 170                 175     


Gln Thr Phe Val Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr 
            180                 185                 190         


Glu Cys Val Glu Val Gln Gly Glu Ala Gly Ser Gly Gly Gly Gly Pro 
        195                 200                 205             


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
    210                 215                 220                 


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
225                 230                 235                 240 


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
                245                 250                 255     


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
            260                 265                 270         


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
        275                 280                 285             


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
    290                 295                 300                 


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
305                 310                 315                 320 


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
                325                 330                 335     


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
            340                 345                 350         


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
        355                 360                 365             


Asp Ser Asp Gly Ser Tyr Phe Met Thr Ser Lys Leu Arg Val Glu Lys 
    370                 375                 380                 


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
385                 390                 395                 400 


Gly Leu His Asn His His Thr Thr Lys Ser Phe Gly Gly Cys Gly Thr 
                405                 410                 415     


Pro Ala Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            420                 425                 430         


Trp His Glu 
        435 


<210>  16
<211>  1308
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16
gatgaagtgg ccattctgcc tgcccctcag cagctctctg tactctcaac caacatgaag       60

catctcttga tgtggagccc agtgatcgcg cctggagaaa cagtgtacta ttctgtcgaa      120

taccaggggg agtacgagag cctgtacacg agccacatct ggattcccag cagctggtgc      180

tcactcactg aaggtcctga gtgtgatgtc actgatgaca tcacggccac tgtgccatac      240

aaccttcgtg tcagggccac attgggctca cagacctcag cctggagcat cctgaagcat      300

ccctttaata gacagtcaac catccttacc cgacctggga tggagatcac caaagatggc      360

ttccacctgg ttattgagct ggaggacctg gggccccagt ttgagttcct tgtggcctac      420

tggaggaggg agcctggtgc cgaggaacat gtcaaaatgg tgaggagtgg gggtattcca      480

gtgcacctag aaaccatgga gccaggggct gcatactgtg tgaaggccca gacattcgtg      540

aaggccattg ggaggtacag cgccttcagc cagacagaat gtgtggaggt gcaaggagag      600

gccggatccg gaggaggtgg tccatccgtc ttcatcttcc ctccaaagat caaggatgta      660

ctcatgatct ccctgagccc catagtcaca tgtgtggtgg tggatgtgag cgaggatgac      720

ccagatgtcc agatcagctg gtttgtgaac aacgtggaag tacacacagc tcagacacaa      780

acccatagag aggattacaa cagtactctc cgggtggtca gtgccctccc catccagcac      840

caggactgga tgagtggcaa ggagttcaaa tgcaaggtca acaacaaaga cctcccagcg      900

cccatcgaga gaaccatctc aaaacccaaa gggtcagtaa gagctccaca ggtatatgtc      960

ttgcctccac cagaagaaga gatgactaag aaacaggtca ctctgacctg catggtcaca     1020

gacttcatgc ctgaagacat ttacgtggag tggaccaaca acgggaaaac agagctaaac     1080

tacaagaaca ctgaaccagt cctggactct gatggttctt acttcatgac cagcaagctg     1140

agagtggaaa agaagaactg ggtggaaaga aatagctact cctgttcagt ggtccacgag     1200

ggtctgcaca atcaccacac gactaagagc ttcggaggtt gcggaacacc agctagcgga     1260

ggactcaacg acatcttcga agcacaaaaa atcgaatggc acgaatga                  1308


<210>  17
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val 
1               5                   10                  15      


Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met 
            20                  25                  30          


Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val 
        35                  40                  45              


Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu 
    50                  55                  60                  


Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr 
65                  70                  75                  80  


Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe 
                85                  90                  95      


Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe 
            100                 105                 110         


Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala 
        115                 120                 125             


Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu 
    130                 135                 140                 


Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
145                 150                 155             


<210>  18
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  18
gcccagggcc aagaattcca ctttgggccc tgccaagtga agggggttgt tccccagaaa       60

ctgtgggaag ccttctgggc tgtgaaagac actatgcaag ctcaggataa catcacgagt      120

gcccggctgc tgcagcagga ggttctgcag aacgtctcgg atgctgagag ctgttacctt      180

gtccacaccc tgctggagtt ctacttgaaa actgttttca aaaactacca caatagaaca      240

gttgaagtca ggactctgaa gtcattctct actctggcca acaactttgt tctcatcgtg      300

tcacaactgc aacccagtca agaaaatgag atgttttcca tcagagacag tgcacacagg      360

cggttcctgc tattccggag agcattcaaa cagttggacg tagaagcagc tctgaccaaa      420

gcccttgggg aagtggacat tcttctgacc tggatgcaga aattctacaa gctctga         477


<210>  19
<211>  154
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  19

Ser Ser Met Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala Thr Asn 
1               5                   10                  15      


Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val Gln 
            20                  25                  30          


Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu Ser 
        35                  40                  45              


Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His Leu 
    50                  55                  60                  


Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro Asp 
65                  70                  75                  80  


His Tyr Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu Thr 
                85                  90                  95      


Ile Lys Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys His Cys 
            100                 105                 110         


Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe Glu 
        115                 120                 125             


Lys Leu Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp 
    130                 135                 140                 


Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
145                 150                 


<210>  20
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Ser Ser Met Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala Thr 
1               5                   10                  15      


Asn Leu Cys Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val 
            20                  25                  30          


Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu 
        35                  40                  45              


Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His 
    50                  55                  60                  


Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro 
65                  70                  75                  80  


Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu 
                85                  90                  95      


Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys His 
            100                 105                 110         


Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe 
        115                 120                 125             


Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu 
    130                 135                 140                 


Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
145                 150                 155 


<210>  21
<211>  156
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  21

Met Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr Asp Leu Gln Glu 
1               5                   10                  15      


Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val Gln Ala Lys Asp 
            20                  25                  30          


Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu Ser Leu Gln Asp 
        35                  40                  45              


Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His Leu Leu Arg Leu 
    50                  55                  60                  


Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro Asp His Tyr Thr 
65                  70                  75                  80  


Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu Thr Ile Lys Lys 
                85                  90                  95      


Asp Leu Arg Leu Cys His Ala His Met Thr Cys His Cys Gly Glu Glu 
            100                 105                 110         


Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe Glu Lys Leu Glu 
        115                 120                 125             


Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp Ile Leu Leu 
    130                 135                 140                 


Gln Trp Met Glu Glu His Glu Val Met Phe Ser Ala 
145                 150                 155     


<210>  22
<211>  471
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  22
atgaaccacg gtctcaggag atgtctgatt tccacagacc ttcaggaaat acgaaatgga       60

ttttctgaga tacggggcag tgtgcaagcc aaagatggaa acattgacat cagaatctta      120

aggaggactg agtctttgca agacacaaag cctgcgaatc gatgctgcct cctgcgccat      180

ttgctaagac tctatctgga cagggtattt aaaaactacc agacccctga ccattatact      240

ctccggaaga tcagcagcct cgccaattcc tttcttacca tcaagaagga cctccggctc      300

tgtcatgccc acatgacatg ccattgtggg gaggaagcaa tgaagaaata cagccagatt      360

ctgagtcact ttgaaaagct ggaacctcag gcagcagttg tgaaggcttt gggggaacta      420

gacattcttc tgcaatggat ggaggagcat gaagtaatgt tctcagctta g               471


<210>  23
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  23

Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro 
1               5                   10                  15      


Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala 
            20                  25                  30          


Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly 
        35                  40                  45              


Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn Phe 
    50                  55                  60                  


Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr 
65                  70                  75                  80  


Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser 
                85                  90                  95      


Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln 
            100                 105                 110         


Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys 
        115                 120                 125             


Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys 
    130                 135                 140                 


Ile 
145 


<210>  24
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  24
catcatcacc atcaccatag cgatatcgag ggccgcgcgc ccatcagctc ccactgcagg       60

cttgacaagt ccaacttcca gcagccctat atcaccaacc gcaccttcat gctggctaag      120

gaggctagct tggctgataa caacacagac gttcgtctca ttggggagaa actgttccac      180

ggagtcagta tgagtgagcg ctgctatctg atgaagcagg tgctgaactt cacccttgaa      240

gaagtgctgt tccctcaatc tgataggttc cagccttata tgcaggaggt ggtgcccttc      300

ctggccaggc tcagcaacag gctaagcaca tgtcatattg aaggtgatga cctgcatatc      360

cagaggaatg tgcaaaagct gaaggacaca gtgaaaaagc ttggagagag tggagagatc      420

aaagcaattg gagaactgga tttgctgttt atgtctctga gaaatgcctg catttga         477


<210>  25
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  25

Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro 
1               5                   10                  15      


Ala Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala 
            20                  25                  30          


Asp Gln Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly 
        35                  40                  45              


Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Gln Phe 
    50                  55                  60                  


Thr Leu Glu Glu Val Phe Lys Asn Tyr Gln Thr Pro Ser His Asp Tyr 
65                  70                  75                  80  


Met Ser Ser Val Ala Asn Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser 
                85                  90                  95      


Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln 
            100                 105                 110         


Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys 
        115                 120                 125             


Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys 
    130                 135                 140                 


Ile 
145 


<210>  26
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  26
atcaccacca tcaccactcc gatattgaag gccgagctcc catttcgtcg cattgccgcc       60

tggacaagag caactttcaa cagcctgcaa tcacgaatcg gacgtttatg ttggcgaagg      120

aagcaagcct ggccgatcag aacacagatg tccgcctgat cggagagaag ctcttccatg      180

gcgtgagcat gtccgagagg tgctacttga tgaaacaagt gttgcagttc actttggaag      240

aagttttcaa gaactatcag accccctccc acgactacat gtcgtcggtg gccaactttt      300

tggcgcgtct gagtaaccga ctgagtacct gtcacatcga gggtgacgat ctgcacattc      360

agcggaatgt acagaagctg aaagacaccg tcaagaaact cggtgagagc ggagagatca      420

aggctatagg cgagctggat ctgctgttca tgtccctccg caatgcctgc atataac         477


<210>  27
<211>  224
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  27

Ala Ala Ala His Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val 
1               5                   10                  15      


Lys Phe Gln Ser Ser Asn Met Glu Asn Ile Leu Thr Trp Asp Ser Gly 
            20                  25                  30          


Pro Glu Gly Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr 
        35                  40                  45              


Gly Glu Arg Asp Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg 
    50                  55                  60                  


Lys Ser Cys Asn Leu Ser Ala Glu Thr Ser Asn Tyr Thr Glu Leu Tyr 
65                  70                  75                  80  


Tyr Ala Arg Val Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys 
                85                  90                  95      


Met Thr Asp Arg Phe Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro 
            100                 105                 110         


Glu Val Ala Leu Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr 
        115                 120                 125             


Ala Pro Glu Lys Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met 
    130                 135                 140                 


Gln Gln Ile Tyr Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr 
145                 150                 155                 160 


Lys Ser Asn Arg Thr Trp Ser Gln Cys Val Thr Asn His Thr Leu Val 
                165                 170                 175     


Leu Thr Trp Leu Glu Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser 
            180                 185                 190         


Phe Val Pro Gly Pro Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys 
        195                 200                 205             


Ala Arg Thr Leu Lys Asp Gln Ser Ser Glu Phe Lys Ala Lys Gly Ser 
    210                 215                 220                 


<210>  28
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  28
gccgcggcac atgcgccaga ggacccatcg gatctgttgc agcacgttaa gtttcagtcg       60

agcaacatgg agaacatact gacatgggat tcgggtccgg agggcacgcc ggacacagtg      120

tatagtattg agtacaagac gtatggcgag agggactggg ttgcgaaaaa gggctgccag      180

cgaatcaccc gaaaaagttg caatctgtcc gccgaaacct ccaattacac cgagttgtac      240

tacgctcgcg tcactgctgt cagcgccgga ggccggtccg ccacgaaaat gacggaccgc      300

ttctatccgt ttttggagac tcagatcggt cctcccgagg ttgcactgac cacagatgag      360

aagtccattt cggtcgtgct cactgcccca gagaagtgga agcgcaaccc cgaagatttg      420

ccggtgtcga tgcagcagat ctacagcaat ctgaagtata acgtgagcgt actcaacacc      480

aagtcgaacc ggacatggtc ccaatgtgtg accaatcata ccctcgtgct gacatggctg      540

gagcccaaca cactctactg cgtgcacgtg gaaagtttcg tacccggacc tccccgtcgc      600

gcccaaccca gcgaaaagca atgcgcccgt acgctgaagg atcagagtag cgagttcaag      660

gcaaaaggat ccgccgcggc acatgcgcca gaggacccat cggatctgtt gcagcacgtt      720

aagtttcagt cgagcaacat ggagaacata ctgacatggg attcgggtcc ggagggcacg      780

ccggacacag tgtatagtat tgagtacaag acgtatggcg agagggactg ggttgcgaaa      840

aagggctgcc agcgaatcac ccgaaaaagt tgcaatctgt ccgccgaaac ctccaattac      900

accgagttgt actacgctcg cgtcactgct gtcagcgccg gaggccggtc cgccacgaaa      960

atgacggacc gcttctatcc gtttttggag actcagatcg gtcctcccga ggttgcactg     1020

accacagatg agaagtccat ttcggtcgtg ctcactgccc cagagaagtg gaagcgcaac     1080

cccgaagatt tgccggtgtc gatgcagcag atctacagca atctgaagta taacgtgagc     1140

gtactcaaca ccaagtcgaa ccggacatgg tcccaatgtg tgaccaatca taccctcgtg     1200

ctgacatggc tggagcccaa cacactctac tgcgtgcacg tggaaagttt cgtacccgga     1260

cctccccgtc gcgcccaacc cagcgaaaag caatgcgccc gtacgctgaa ggatcagagt     1320

agcgagttca aggcaaaagg atcc                                            1344


<210>  29
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  29

Ala Val Pro Cys Val Ser Gly Gly Leu Pro Lys Pro Ala Asn Ile Thr 
1               5                   10                  15      


Phe Leu Ser Ser Asn Phe Glu Asn Val Leu Gln Trp Thr Pro Pro Glu 
            20                  25                  30          


Gly Leu Gln Gly Val Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr 
        35                  40                  45              


Gly Gln Lys Lys Trp Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg 
    50                  55                  60                  


Thr Tyr Cys Asp Leu Ser Ala Glu Thr Ser Asp Leu Glu His Gln Tyr 
65                  70                  75                  80  


Tyr Ala Lys Val Lys Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala 
                85                  90                  95      


Glu Ser Gly Arg Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro 
            100                 105                 110         


Asp Val Thr Cys Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His 
        115                 120                 125             


Pro Thr Pro Thr Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu 
    130                 135                 140                 


Glu Asp Ile Phe His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn 
145                 150                 155                 160 


Arg Thr Tyr Gln Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe 
                165                 170                 175     


Phe Gly Leu Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys 
            180                 185                 190         


Val Pro Thr Trp Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys 
        195                 200                 205             


Thr Leu Pro Asp Arg Thr 
    210                 


<210>  30
<211>  657
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  30
gccgcggccg tgccctgtgt ttcgggcggt ctgcccaagc ctgctaatat cacgtttttg       60

tccagcaatt tcgagaacgt gctccagtgg acgccaccgg aaggattgca gggcgtgaag      120

gtcacatata ccgtgcagta cttcatatac ggacagaaaa agtggttgaa caagagcgag      180

tgtcgtaata tcaacaggac ctactgcgat ctgtcggcag aaacctcgga tctggagcat      240

cagtactacg ctaaggtcaa ggccatctgg ggcaccaagt gcagcaagtg ggccgaaagt      300

ggacgattct ccagcctgca acacacaacc ctgaagccgc cagacgtcac atgcatctcc      360

aaagtgcgca gtatccagat gatcgtgcat cccacaccca ccccgattcg tgcaggcgac      420

ggtcaccggc tgactctgga ggacattttt cacgatctgt tctaccatct ggagttgcaa      480

gtaaaccgca cttatcagat gcacctcggt ggcaaacaac gcgagtatga gttctttggc      540

ctgacaccag ataccgaatt tctcggcacc ataatgattt gcgtacctac ttgggccaaa      600

gagagtgccc cctatatgtg cagggttaag acattgccgg accgcacgtc gggatcc         657


<210>  31
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  31

His Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln 
1               5                   10                  15      


Ser Ser Asn Met Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly 
            20                  25                  30          


Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg 
        35                  40                  45              


Asp Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys 
    50                  55                  60                  


Asn Leu Ser Ala Glu Thr Ser Asn Tyr Thr Glu Leu Tyr Tyr Ala Arg 
65                  70                  75                  80  


Val Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp 
                85                  90                  95      


Arg Phe Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu Val Ala 
            100                 105                 110         


Leu Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu 
        115                 120                 125             


Lys Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile 
    130                 135                 140                 


Tyr Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn 
145                 150                 155                 160 


Arg Thr Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu Thr Trp 
                165                 170                 175     


Leu Glu Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe Val Pro 
            180                 185                 190         


Gly Pro Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala Arg Thr 
        195                 200                 205             


Leu Lys Asp Gln Ser Ser Glu Phe Lys Ala Lys Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
225                 230                 235                 240 


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
                245                 250                 255     


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
            260                 265                 270         


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
        275                 280                 285             


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
    290                 295                 300                 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
305                 310                 315                 320 


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
                325                 330                 335     


Tyr Val Leu Pro Pro Pro Cys Glu Glu Met Thr Lys Lys Gln Val Thr 
            340                 345                 350         


Leu Tyr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
        355                 360                 365             


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
385                 390                 395                 400 


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
                405                 410                 415     


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
            420                 425                 430         


Pro Gly Lys Gly Leu Glu Ala Ser Gly Thr Gly His His His His His 
        435                 440                 445             


His 
    


<210>  32
<211>  1350
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  32
catgcgccag aggacccatc ggatctgttg cagcacgtta agtttcagtc gagcaacatg       60

gagaacatac tgacatggga ttcgggtccg gagggcacgc cggacacagt gtatagtatt      120

gagtacaaga cgtatggcga gagggactgg gttgcgaaaa agggctgcca gcgaatcacc      180

cgaaaaagtt gcaatctgtc cgccgaaacc tccaattaca ccgagttgta ctacgctcgc      240

gtcactgctg tcagcgccgg aggccggtcc gccacgaaaa tgacggaccg cttctatccg      300

tttttggaga ctcagatcgg tcctcccgag gttgcactga ccacagatga gaagtccatt      360

tcggtcgtgc tcactgcccc agagaagtgg aagcgcaacc ccgaagattt gccggtgtcg      420

atgcagcaga tctacagcaa tctgaagtat aacgtgagcg tactcaacac caagtcgaac      480

cggacatggt cccaatgtgt gaccaatcat accctcgtgc tgacatggct ggagcccaac      540

acactctact gcgtgcacgt ggaaagtttc gtacccggac ctccccgtcg cgcccaaccc      600

agcgaaaagc aatgcgcccg tacgctgaag gatcagagta gcgagttcaa ggcaaaagga      660

tccggaggag gtggtccatc cgtcttcatc ttccctccaa agatcaagga tgtactcatg      720

atctccctga gccccatagt cacatgtgtg gtggtggatg tgagcgagga tgacccagat      780

gtccagatca gctggtttgt gaacaacgtg gaagtacaca cagctcagac acaaacccat      840

agagaggatt acaacagtac tctccgggtg gtcagtgccc tccccatcca gcaccaggac      900

tggatgagtg gcaaggagtt caaatgcaag gtcaacaaca aagacctccc agcgcccatc      960

gagagaacca tctcaaaacc caaagggtca gtaagagctc cacaggtata tgtcttgcct     1020

ccaccatgcg aagagatgac taagaaacag gtcactctgt actgcatggt cacagacttc     1080

atgcctgaag acatttacgt ggagtggacc aacaacggga aaacagagct aaactacaag     1140

aacactgaac cagtcctgga ctctgatggt tcttacttca tgtacagcaa gctgagagtg     1200

gaaaagaaga actgggtgga aagaaatagc tactcctgtt cagtggtcca cgagggtctg     1260

cacaatcacc acacgactaa gagcttctcc cggactccgg gtaaaggtct cgaggctagc     1320

ggaaccggtc atcatcacca tcaccattga                                      1350


<210>  33
<211>  460
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  33

Val Pro Cys Val Ser Gly Gly Leu Pro Lys Pro Ala Asn Ile Thr Phe 
1               5                   10                  15      


Leu Ser Ser Asn Phe Glu Asn Val Leu Gln Trp Thr Pro Pro Glu Gly 
            20                  25                  30          


Leu Gln Gly Val Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly 
        35                  40                  45              


Gln Lys Lys Trp Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr 
    50                  55                  60                  


Tyr Cys Asp Leu Ser Ala Glu Thr Ser Asp Leu Glu His Gln Tyr Tyr 
65                  70                  75                  80  


Ala Lys Val Lys Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu 
                85                  90                  95      


Ser Gly Arg Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp 
            100                 105                 110         


Val Thr Cys Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro 
        115                 120                 125             


Thr Pro Thr Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu 
    130                 135                 140                 


Asp Ile Phe His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg 
145                 150                 155                 160 


Thr Tyr Gln Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe 
                165                 170                 175     


Gly Leu Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val 
            180                 185                 190         


Pro Thr Trp Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr 
        195                 200                 205             


Leu Pro Asp Arg Thr Ser Gly Ser Gly Gly Gly Gly Pro Ser Val Phe 
    210                 215                 220                 


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
225                 230                 235                 240 


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
                245                 250                 255     


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
            260                 265                 270         


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
        275                 280                 285             


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
    290                 295                 300                 


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
305                 310                 315                 320 


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
                325                 330                 335     


Pro Cys Glu Glu Met Thr Lys Lys Gln Val Thr Leu Tyr Cys Met Val 
            340                 345                 350         


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
        355                 360                 365             


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
    370                 375                 380                 


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
385                 390                 395                 400 


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
                405                 410                 415     


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly Leu 
            420                 425                 430         


Glu Ala Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
        435                 440                 445             


Trp His Glu Gly Thr Gly His His His His His His 
    450                 455                 460 


<210>  34
<211>  1383
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  34
gtgccctgtg tttcgggcgg tctgcccaag cctgctaata tcacgttttt gtccagcaat       60

ttcgagaacg tgctccagtg gacgccaccg gaaggattgc agggcgtgaa ggtcacatat      120

accgtgcagt acttcatata cggacagaaa aagtggttga acaagagcga gtgtcgtaat      180

atcaacagga cctactgcga tctgtcggca gaaacctcgg atctggagca tcagtactac      240

gctaaggtca aggccatctg gggcaccaag tgcagcaagt gggccgaaag tggacgattc      300

tccagcctgc aacacacaac cctgaagccg ccagacgtca catgcatctc caaagtgcgc      360

agtatccaga tgatcgtgca tcccacaccc accccgattc gtgcaggcga cggtcaccgg      420

ctgactctgg aggacatttt tcacgatctg ttctaccatc tggagttgca agtaaaccgc      480

acttatcaga tgcacctcgg tggcaaacaa cgcgagtatg agttctttgg cctgacacca      540

gataccgaat ttctcggcac cataatgatt tgcgtaccta cttgggccaa agagagtgcc      600

ccctatatgt gcagggttaa gacattgccg gaccgcacgt cgggatccgg aggaggtggt      660

ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cctgagcccc      720

atagtcacat gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca gatcagctgg      780

tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac      840

agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag      900

gagttcaaat gcaaggtcaa caacaaagac ctcccagcgc ccatcgagag aaccatctca      960

aaacccaaag ggtcagtaag agctccacag gtatatgtct tgcctccacc atgcgaagag     1020

atgactaaga aacaggtcac tctgtactgc atggtcacag acttcatgcc tgaagacatt     1080

tacgtggagt ggaccaacaa cgggaaaaca gagctaaact acaagaacac tgaaccagtc     1140

ctggactctg atggttctta cttcatgtac agcaagctga gagtggaaaa gaagaactgg     1200

gtggaaagaa atagctactc ctgttcagtg gtccacgagg gtctgcacaa tcaccacacg     1260

actaagagct tctcccggac tccgggtaaa ggtctcgagg ctagcggagg actcaacgac     1320

atcttcgaag cacaaaaaat cgaatggcac gaaggtaccg gtcatcatca ccatcaccat     1380

tga                                                                   1383


<210>  35
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  35

Gly Leu Lys Thr Leu Asn Leu Gly Ser Cys 
1               5                   10  


<210>  36
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  36

Ala Ser Ser Met Lys Thr Leu Asn Leu Gly Ser Cys 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  37

Cys Ser Ser Met Lys Thr Leu Asn Leu Gly Ser Cys 
1               5                   10          


<210>  38
<211>  155
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  38

Ala Ser Ser Met Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala Thr 
1               5                   10                  15      


Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val 
            20                  25                  30          


Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu 
        35                  40                  45              


Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His 
    50                  55                  60                  


Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro 
65                  70                  75                  80  


Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu 
                85                  90                  95      


Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys His 
            100                 105                 110         


Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe 
        115                 120                 125             


Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu 
    130                 135                 140                 


Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
145                 150                 155 


<210>  39
<211>  155
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  39

Cys Ser Ser Met Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala Thr 
1               5                   10                  15      


Asn Leu Cys Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val 
            20                  25                  30          


Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu 
        35                  40                  45              


Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His 
    50                  55                  60                  


Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro 
65                  70                  75                  80  


Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu 
                85                  90                  95      


Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys His 
            100                 105                 110         


Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe 
        115                 120                 125             


Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu 
    130                 135                 140                 


Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
145                 150                 155 


<210>  40
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  40

His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn 
1               5                   10                  15      


Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Gln Asn Thr 
            20                  25                  30          


Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser 
        35                  40                  45              


Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Gln Phe Thr Leu Glu Glu 
    50                  55                  60                  


Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val 
65                  70                  75                  80  


Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile 
                85                  90                  95      


Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp 
            100                 105                 110         


Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu 
        115                 120                 125             


Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
    130                 135                 140     


<210>  41
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  41

His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Ala Ile Thr Asn 
1               5                   10                  15      


Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Gln Asn Thr 
            20                  25                  30          


Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser 
        35                  40                  45              


Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Gln Phe Thr Leu Glu Glu 
    50                  55                  60                  


Val Phe Lys Asn Tyr Gln Thr Pro Ser His Asp Tyr Met Ser Ser Val 
65                  70                  75                  80  


Ala Asn Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile 
                85                  90                  95      


Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp 
            100                 105                 110         


Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu 
        115                 120                 125             


Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
    130                 135                 140     


<210>  42
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  42

Ile Glu Gly Arg Leu Glu Ser Arg Gly Pro Phe Glu Gly Lys Pro Ile 
1               5                   10                  15      


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His 
            20                  25                  30          


His His His 
        35  


<210>  43
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  43

Ile Glu Gly Arg Val Glu Ser Arg Gly Pro Phe Glu Gly Lys Pro Ile 
1               5                   10                  15      


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His 
            20                  25                  30          


His His His 
        35  


<210>  44
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  44

His His His His His His Ser Asp Ile Glu Gly Arg Ala 
1               5                   10              


<210>  45
<211>  157
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  45

His Met Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr Asp Leu Gln 
1               5                   10                  15      


Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val Gln Ala Lys 
            20                  25                  30          


Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu Ser Leu Gln 
        35                  40                  45              


Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His Leu Leu Arg 
    50                  55                  60                  


Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro Asp His Tyr 
65                  70                  75                  80  


Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu Thr Ile Lys 
                85                  90                  95      


Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys His Cys Gly Glu 
            100                 105                 110         


Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe Glu Lys Leu 
        115                 120                 125             


Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp Ile Leu 
    130                 135                 140                 


Leu Gln Trp Met Glu Glu His Glu Val Met Phe Ser Ala 
145                 150                 155         


