                         SEQUENCE LISTING

<110>  METHEOR THERAPEUTICS CORPORATION
 
<120>  OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR 
       USE IN TREATING DISEASES

<130>  MTC-01PCT

<150>  61/669,606
<151>  2012-07-09

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n= Cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n= Cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (8)..(15)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n=5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n=5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n= a, c, g, or t

<400>  1
nngnnngnnn nnnnnngnnn gn                                                22


<210>  2
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n=5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or  deoxyzebularine

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n=5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or  deoxyzebularine

<220>
<221>  misc_feature
<222>  (8)..(15)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n= Cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n= Cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n= a, c, g, or t

<400>  2
nngnnngnnn nnnnnngnnn gn                                                22


<210>  3
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= 5-aza-5,6-dihydro-dCytosine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= 5-aza-5,6-dihydro-dCytosine

<400>  3
cctatgcgat cgagttttct ngatngcata gg                                     32


<210>  4
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n=  zebularine (pyrimidin-2-one ribonucleoside)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n=  zebularine (pyrimidin-2-one ribonucleoside)

<400>  4
cctatgcgat cgagttttct ngatngcata gg                                     32


<210>  5
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n= 5-methylcytosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n= 5-methylcytosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= 5-aza-5,6-dihydro-dC

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= 5-aza-5,6-dihydro-dC

<400>  5
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  6
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n= 5-methylcytosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n= 5-methylcytosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= zebularine (pyrimidin-2-one ribonucleoside)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= zebularine (pyrimidin-2-one ribonucleoside)

<400>  6
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n= 5-aza-5,6-dihydro-dCytosine

<400>  7
gtacatgngc tccaga                                                       16


<210>  8
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  8
tctggagcgc atgtac                                                       16


<210>  9
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n=5-aza-5,6-dihydro-dC

<400>  9
gtacatgngc tccaga                                                       16


<210>  10
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n= 5-methylcytosine

<400>  10
tctggagngc atgtac                                                       16


<210>  11
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= deoxy-zebularine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= deoxy-zebularine

<400>  11
cctatgcgat cgagttttct ngatngcata gg                                     32


<210>  12
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n=5-methylcytosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n=5-methylcytosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n== deoxy-zebularine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n== deoxy-zebularine

<400>  12
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  13
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13
cctatggcat gcagttttct gcatgccata gg                                     32


<210>  14
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n=5-methylcytosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n=5-methylcytosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= deoxy-zebularine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= deoxy-zebularine

<400>  14
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  15
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n=5-aza-5,6-dihydro-dC

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n=5-aza-5,6-dihydro-dC

<400>  15
cctatgngat ngagttttct cgatcgcata gg                                     32


<210>  16
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n=zebularine (pyrimidin-2-one ribonucleoside)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n=zebularine (pyrimidin-2-one ribonucleoside)

<400>  16
cctatgngat ngagttttct cgatcgcata gg                                     32


<210>  17
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n= 5-aza-5,6-dihydro-dC

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n= 5-aza-5,6-dihydro-dC

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= 5-methylcytosine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= 5-methylcytosine

<400>  17
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  18
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n= zebularine (pyrimidin-2-one ribonucleoside)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n= zebularine (pyrimidin-2-one ribonucleoside)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= 5-methylcytosine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= 5-methylcytosine

<400>  18
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  19
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n= deoxy-zebularine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n= deoxy-zebularine

<400>  19
cctatgngat ngagttttct cgatcgcata gg                                     32


<210>  20
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = deoxy-zebularine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = deoxy-zebularine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= 5-methylcytosine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= 5-methylcytosine

<400>  20
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  21
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21
gtacatgcgc tccaga                                                       16


<210>  22
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n= 5-aza-5,6-dihydro-dC

<400>  22
tctggagcgn atgtac                                                       16


<210>  23
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n= 5-methylcytosine

<400>  23
gtacatgngc tccaga                                                       16


<210>  24
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n=5-aza-5,6-dihydro-dC

<400>  24
tctggagngc atgtac                                                       16


<210>  25
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n= cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n= cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= 5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= 5-aza-5,6-dihydro-dC; 5-Aza-2 deoxycytidine; zebularine; or 
       deoxyzebularine

<400>  25
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  26
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n= 5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n= 5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n= cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n= cytosine or 5-methylcytosine

<400>  26
cctatgngat ngagttttct ngatngcata gg                                     32


<210>  27
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n= Cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n= Cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (8)..(19)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n=5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n= a,c, g, t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n=5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n= a,c, g, t

<400>  27
nngnnngnnn nnnnnnnnnn gnnngn                                            26


<210>  28
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n=5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n=5-aza-cytidine, 5-aza-2'-deoxycytidine, 5-fluoro-cytidine, 
       fluorocyclopentenylcytosine, zebularine, or deoxyzebularine

<220>
<221>  misc_feature
<222>  (8)..(19)
<223>  n= a, c, g, or t

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n= Cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n= a, c, g, t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n= Cytosine or 5-methylcytosine

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n= a, c, g, t

<400>  28
nngnnngnnn nnnnnnnnnn gnnngn                                            26


