                         SEQUENCE LISTING

<110>  ProQR Therapeutics B.V.
 
<120>  Exon replacement with stabilized artificial RNAs

<130>  P6042220PCT

<160>  10    

<170>  PatentIn version 3.3

<210>  1
<211>  193
<212>  RNA
<213>  Artificial

<220>
<223>  Exon 10 of the CFTR transcript

<400>  1
gacuucacuu cuaaugguga uuaugggaga acuggagccu ucagagggua aaauuaagca     60

caguggaaga auuucauucu guucucaguu uuccuggauu augccuggca ccauuaaaga    120

aaauaucauc uuugguguuu ccuaugauga auauagauac agaagcguca ucaaagcaug    180

ccaacuagaa gag                                                       193


<210>  2
<211>  10
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide

<400>  2
tactaactgt                                                            10


<210>  3
<211>  5
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide

<400>  3
ctaat                                                                  5


<210>  4
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide

<400>  4
cctttcttct tttccttcc                                                  19


<210>  5
<211>  10
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide

<400>  5
ttttatttcc                                                            10


<210>  6
<211>  6
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide

<400>  6
gtaagt                                                                 6


<210>  7
<211>  9
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide

<400>  7
tccctccag                                                              9


<210>  8
<211>  566
<212>  RNA
<213>  Artificial

<220>
<223>  Polynucleotide

<400>  8
uccaauuauc auccuaagca gaaguguaua uucuuauuug uaaagauucu auuaacucau     60

uugauucaaa auauuuaaaa uacuuccugu uucagguacu cugcuaugca caaaagauac    120

aagggaaagu aaaagagaca ggcaagugaa uccugagcgu gauuugauaa ugaccuaaua    180

augauggguu uuauuuccag acuucacuuc uaauggugau uaugggagaa cuggagccuu    240

cagaggguaa aauuaagcac aguggaagaa uuucauucug uucucaguuu uccuggauua    300

ugccuggcac cauuaaagaa aauaucaucu uugguguuuc cuaugaugaa uauagauaca    360

gaagcgucau caaagcaugc caacuagaag agguaagaaa cucucuuucu uuccaugggu    420

uggccuugau ccauucacag uagcuuaccc auagaggaaa cauaaauaua uguagacuaa    480

ccgauugaau auggagccaa auauauaauu uggguagugu gaaggguuca uaugcauaau    540

caaaaaguuu ucacauaguu ucuuac                                         566


<210>  9
<211>  548
<212>  RNA
<213>  Artificial

<220>
<223>  Polynucleotide

<400>  9
uccaauuauc auccuaagca gaaguguaua uucuuauuug uaaagauucu auuaacucau     60

uugauucaaa auauuuaaaa uacuuccugu uucagguacu cugcuaugca caaaagauac    120

aagggaaagu aaaagagaca gauaaugacc uacuaacugu gccuuucuuc uuuuccuucc    180

agacuucacu ucuaauggug auuaugggag aacuggagcc uucagagggu aaaauuaagc    240

acaguggaag aauuucauuc uguucucagu uuuccuggau uaugccuggc accauuaaag    300

aaaauaucau cuuugguguu uccuaugaug aauauagaua cagaagcguc aucaaagcau    360

gccaacuaga agagguaaga aacucucuuu cuuuccaugg guuggccuug auccauucac    420

aguagcuuac ccauagagga aacauaaaua uauguagacu aaccgauuga auauggagcc    480

aaauauauaa uuuggguagu gugaaggguu cauaugcaua aucaaaaagu uuucacauag    540

uuucuuac                                                             548


<210>  10
<211>  548
<212>  RNA
<213>  Artificial

<220>
<223>  Polynucleotide

<400>  10
ugccaagugc ucacucugug ucgagugcug uucuaugugc uuuaacuaua uuaauuuauu     60

uaaucuucac agaaauccua caaaguagau uaccuucaua uuauuaggua cagauuaagu    120

aauagagaca uauucaggua gauaaugacc uacuaacugu gccuuucuuc uuuuccuucc    180

agacuucacu ucuaauggug auuaugggag aacuggagcc uucagagggu aaaauuaagc    240

acaguggaag aauuucauuc uguucucagu uuuccuggau uaugccuggc accauuaaag    300

aaaauaucau cuuugguguu uccuaugaug aauauagaua cagaagcguc aucaaagcau    360

gccaacuaga agagguaaga aacucucuuu cuuuccaugg guuggccuaa auaaucuuaa    420

uaauuuuugg aguauauuuu uaaagaugca uauuuugugg uaucuuuuaa aaagauacca    480

cauaucacuu auaugcaugc cauauaaaua accauugagg acguuugucu cacuaaugag    540

ugaacaaa                                                             548


