                         SEQUENCE LISTING

<110>  UNIVERSIDAD DE VALLADOLID
 
<120>  MUTANTES DE APOACUORINA Y METODOS PARA SU USO

<130>  P8557PC00

<150>  ES P201231104
<151>  2012-07-13

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  189
<212>  PRT
<213>  Aequorea victoria

<400>  1

Gly Lys Leu Thr Ser Asp Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
1               5                   10                  15      


Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser 
            20                  25                  30          


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
        35                  40                  45              


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
    50                  55                  60                  


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
65                  70                  75                  80  


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
                85                  90                  95      


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
            100                 105                 110         


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
        115                 120                 125             


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
    130                 135                 140                 


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
145                 150                 155                 160 


Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met 
                165                 170                 175     


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
            180                 185                 


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  2

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  3

Pro Gln Lys Lys Ile Lys Ser 
1               5           


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  4

Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  5

Gln Pro Lys Lys Pro 
1               5   


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  6

Arg Lys Lys Arg 
1               


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  7

Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala His Gln 
1               5                   10          


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  8

Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln Arg 
1               5                   10                  15      


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  9

Met Pro Leu Thr Arg Arg Arg Pro Ala Ala Ser Gln Ala Leu Ala Pro 
1               5                   10                  15      


Pro Thr Pro 
            


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  10

Gly Ala Ala Leu Thr Ile Leu Val 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin nuclear

<400>  11

Gly Ala Ala Leu Thr Leu Leu Gly 
1               5               


<210>  12
<211>  201
<212>  PRT
<213>  Xenopus laevis

<400>  12

Met Ala Ser Thr Val Ser Asn Thr Ser Lys Leu Glu Lys Pro Val Ser 
1               5                   10                  15      


Leu Ile Trp Gly Cys Glu Leu Asn Glu Gln Asn Lys Thr Phe Glu Phe 
            20                  25                  30          


Lys Val Glu Asp Asp Glu Glu Lys Cys Glu His Gln Leu Ala Leu Arg 
        35                  40                  45              


Thr Val Cys Leu Gly Asp Lys Ala Lys Asp Glu Phe His Ile Val Glu 
    50                  55                  60                  


Ile Val Thr Gln Glu Glu Gly Ala Glu Lys Ser Val Pro Ile Ala Thr 
65                  70                  75                  80  


Leu Lys Pro Ser Ile Leu Pro Met Ala Thr Met Val Gly Ile Glu Leu 
                85                  90                  95      


Thr Pro Pro Val Thr Phe Arg Leu Lys Ala Gly Ser Gly Pro Leu Tyr 
            100                 105                 110         


Ile Ser Gly Gln His Val Ala Met Glu Glu Asp Tyr Ser Trp Ala Glu 
        115                 120                 125             


Glu Glu Asp Glu Gly Glu Ala Glu Gly Glu Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Asp Gln Glu Ser Pro Pro Lys Ala Val Lys Arg Pro Ala Ala Thr 
145                 150                 155                 160 


Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu Asp Lys Glu Asp Glu 
                165                 170                 175     


Ser Ser Glu Glu Asp Ser Pro Thr Lys Lys Gly Lys Gly Ala Gly Arg 
            180                 185                 190         


Gly Arg Lys Pro Ala Ala Lys Lys Val 
        195                 200     


<210>  13
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  residuos 1-81 de la galactosiltransferasa humana

<400>  13

Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly 
    


<210>  14
<211>  550
<212>  PRT
<213>  Photinus pyralis

<400>  14

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asn Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Asn Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ser Lys Leu 
545                 550 


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secuencia de localizacin a mitocondria

<400>  15

Arg Arg Ile Val Val Leu His Gly Tyr Gly Ala Val Lys Glu Val Leu 
1               5                   10                  15      


Leu Asn His Lys 
            20  


<210>  16
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aminocidos 74-95 del citocromo P450 2E1 de rata

<400>  16

Ser Arg Arg Ile Val Val Leu His Gly Tyr Lys Ala Val Lys Glu Val 
1               5                   10                  15      


Leu Leu Asn His Lys Asn 
            20          


<210>  17
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secuencia del precursor de la citocromo c oxidasa IV de levadura

<400>  17

Met Leu Ser Leu Arg Gln Asp Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg 
            20          


<210>  18
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Leu Leu Asn Leu Ile Ser Lys Leu Phe 
1               5                   10  


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de localizacin mitocondrial


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Met Leu Phe Asn Leu Arg Xaa Xaa Leu Asn Asn Ala Ala Phe Arg His 
1               5                   10                  15      


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Xaa 
            20                  25                  30          


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secuencia de direccionamiento a la ruta secretora

<400>  20

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe Trp Ala 
1               5                   10                  15      


Thr Glu Ala Glu Gln Leu Thr Lys Cys Glu Val Phe Gln 
            20                  25                  


<210>  21
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu 
            20                  25  


<210>  22
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys 
            20                  25  


<210>  23
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala 
            20  


<210>  24
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ser Pro Arg Ser Ser Gly Gln Pro Gly Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Ala Arg Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu 
            20                  25                  30          


Leu Pro Leu Ala Pro Gly 
        35              


<210>  25
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala 
    


<210>  26
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Lys Gly Leu Thr Val Ala Gly Leu Arg Ser Gly His Ile Tyr Gly 
            20                  25                  30      


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de retencin en el retculo endoplsmico

<400>  27

Lys Asp Glu Leu 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de retencin en el retculo endoplsmico

<400>  28

Asp Asp Glu Leu 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de retencin en el retculo endoplsmico

<400>  29

Asp Glu Glu Leu 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de retencin en el retculo endoplsmico

<400>  30

Gln Glu Asp Leu 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de retencin en el retculo endoplsmico

<400>  31

Arg Asp Glu Leu 
1               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido de retencin en el retculo endoplsmico

<400>  32

Gly Gln Asn Leu Ser Thr Ser Asn 
1               5               


<210>  33
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protena verde fluorescente (GFP) de Aequorea victoria que 
       presenta las mutaciones F99S, M153T y V163A

<400>  33

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Ser Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  34
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  34

Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  35

Gly Ser Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  36

Glu Gly Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10              


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  37

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gln 
1               5                   10                  15  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  38

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  39

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  40

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  41

Glu Ser Gly Ser Val Ser Ser Glu Glu Leu Ala Phe Arg Ser Leu Asp 
1               5                   10                  15      


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  42

Thr Ala Thr Pro Ala Thr Thr Pro Thr Thr Ala Pro Thr Ala Gly Thr 
1               5                   10                  15      


<210>  43
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  43

Thr Ala Thr Pro Ala Thr Thr Pro Thr Thr Ala Pro Thr Ala Gly Thr 
1               5                   10                  15      


Thr Ala Thr Pro Ala Thr Thr Pro Thr Thr Ala Pro Thr Ala Gly Thr 
            20                  25                  30          


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  residuos 53-56 y 57-59 de tetranectina

<400>  44

Gly Thr Lys Val His Met Lys 
1               5           


<210>  45
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aminocidos 1992-2102 de la fibronectina humana

<400>  45

Asp Glu Leu Pro Gln Leu Val Thr Leu Pro His Pro Asn Leu His Gly 
1               5                   10                  15      


Pro Glu Ile Leu Asp Val Pro Ser Thr Val Gln Lys Thr Pro Phe Val 
            20                  25                  30          


Thr His Pro Gly Tyr Asp Thr Gly Asn Gly Ile Gln Leu Pro Gly Thr 
        35                  40                  45              


Ser Gly Gln Gln Pro Ser Val Gly Gln Gln Met Ile Phe Glu Glu His 
    50                  55                  60                  


Gly Phe Arg Arg Thr Thr Pro Pro Thr Thr Ala Thr Pro Ile Arg His 
65                  70                  75                  80  


Arg Pro Arg Pro Tyr Pro Pro Asn Val Gly Glu Glu Ile Gln Ile Gly 
                85                  90                  95      


His Ile Pro Arg Glu Asp Val Asp Tyr His Leu Tyr Pro His Gly 
            100                 105                 110     


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aminocidos 2037-2049 de la fibronectina humana

<400>  46

Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln Gln 
1               5                   10              


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aminocidos 2038-2042 de la fibronectina humana

<400>  47

Gly Thr Ser Gly Gln 
1               5   


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secuencia de 10 aminocidos de la regin de la bisagra superior 
       de la IgG3 murina

<400>  48

Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
1               5                   10  


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  49

Ala Pro Ala Glu Thr Lys Ala Glu Pro Met Thr 
1               5                   10      


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  50

Ser Gly Gly Ser Gly Ser Gly Gly Gln 
1               5                   


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pptido enlazador

<400>  51

Gly Gly Ser Ser Arg Ser Ser Ser 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  residuos 49-57 de la protena TAT de HIV

<400>  52

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variante sinttica del pptido de residuos 49-57 de la protena 
       TAT de HIV

<400>  53

Tyr Ala Arg Lys Ala Arg Arg Gln Ala Arg Arg 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variante sinttica del pptido de residuos 49-57 de la protena 
       TAT de HIV

<400>  54

Tyr Ala Arg Ala Ala Arg Arg Ala Ala Arg Arg 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variante sinttica del pptido de residuos 49-57 de la protena 
       TAT de HIV

<400>  55

Tyr Ala Arg Ala Ala Arg Arg Ala Ala Arg Ala 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variante sinttica del pptido de residuos 49-57 de la protena 
       TAT de HIV

<400>  56

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secuencia derivada de la tercera hlice del homeodominio de la 
       protena Antennapedia

<400>  57

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  58
<211>  3624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  secuencia nucleotidica de la protena er-GAP2.2

<400>  58
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtaa ggggctcaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggt gtccactccc aggtccaact gcagcagcct ggggctgagc ttgtgaagcc      180

tggggcttca gtgaagctgt cctgcaaggc ttctggctac accttcacca gctactggat      240

gcactgggtg aagcagaggc ctggacgagg ccttgagtgg attggaagga ttgatcctaa      300

tagtggtggt actaagtaca atgagaagtt caagagcaag gccacactga ctgtagacaa      360

accctccagc acagcctaca tgcagctcag cagcctgaca tctgaggact ctgcggtcta      420

ttattgtgca agatacgatt actacggtag tagctacttt gactactggg gccaaggcac      480

cactctcaca gtctcctcag gtgagtcctt acaacctctc tcttctattc agcttaaata      540

gattttactg catttgttgg gggggaaatg tgtgtatctg aatttcaggt catgaaggac      600

tagggacacc ttgggagtca gaaagggtca ttgggagccc tggctgatgc agacagacat      660

cctcagctcc cagacttcat ggccagagat ttatagggat ctctagaaga atgcagcata      720

cactcctatt tcaaggggta ctggcaagag aaaaggactt tccttgggac tggccacatt      780

aacactatta gggaggacac agaacagtgt aaagaatgag gaaggggaag gaaggtggct      840

gagtttaaca ggttctcatc aagaggtctg agctgtgtag aacaagtaac agatagtagc      900

cagctacatc aagagagaaa ggctgcccac acagggaaag catagggtag gaggttgttg      960

gttatcctca gaaagcaggg accaaggtcc aaggagagct aaacccatgg atagagacct     1020

agaaccaaga tttaggagcc agagcttgaa taagcatagt agactaaaaa ggggcttctg     1080

aaaggcatca tcactaaagg atcagggttc atgggactag agagatggct gagtggtgaa     1140

aaggaatagc tactctttca gaggacccag gttcagctaa caacaaccag atggcatctt     1200

acaatggact gtaagaaaca ccagtttctg ggtattcacc gctcctttct accagcacag     1260

ccatcgggca cacacataat acacaaattc acacatcgaa aataaaaaac atggaaaaat     1320

taaggtcaca gtgcaagctc tggaggtgga aatttctgac actgcttgcc tcagatcaat     1380

tgtagaagac acggttctaa gagcaaagct aagaacagaa tctctccaaa tatccgaggc     1440

cactgataag aaaaagctca cacattctcc tctcttgcag ccaaaacaac acccccatca     1500

gtctatccac tggcccctgg gtgtggagat acaactggtt cctccgtgac tctgggatgc     1560

ctggtcaagg gctacttccc tgagtcagtg actgtgactt ggaactctgg atccctgtcc     1620

agcagtgtgc acaccttccc agctctcctg cagtctggac tctacactat gagcagctca     1680

gtgactgtcc cctccagcac ctggccaagt cagaccgtca cctgcagcgt tgctcaccca     1740

gccagcagca ccacggtgga caaaaaactt ggtgagagga cattcagggg aggagggatt     1800

caccagagtt gaggcaaagg tattagccta tctaaaccag ccaggctggg atccatcacc     1860

aaggaggtga ccttagccca gggaagaggg agatactgtc tctgcctccc tcctgggaac     1920

atctagctat gaccacctac actcaaggac atgatcctct gggataggtg tgcttgtcat     1980

ttccaggatc atcctggact aagcccatac cagggacaaa ctttcctctc tctggtttgg     2040

tgcttctctc cttcaaaaac cagtaacatc cagccttctc tctgcagagc ccagcgggcc     2100

catttcaaca atcaacccct gtcctccatg caaggagtgt cacaaatgcc caggtaagtc     2160

actaccagag ctccactccc aggagaatgg taagtgctgt aaaaatccct gtaatggagg     2220

ataagccatg tacaaatcca tttccatctc tcctcatcag ctcctaacct cgacggtatc     2280

gataagctta gcaaaggaga agaacttttc actggagttg tcccaattct tgttgaatta     2340

gatggtgatg ttaatgggca caaattttct gtcagtggag agggtgaagg tgatgctaca     2400

tacggaaaac ttacccttaa atttatttgc actactggaa aactacctgt tccatggcca     2460

acacttgtca ctactttctc ttatggtgtt caatgctttt cccgttatcc ggatcatatg     2520

aaacggcatg actttttcaa gagtgccatg cccgaaggtt atgtacagga acgcactata     2580

tctttcaaag atgacgggaa ctacaagacg cgtgctgaag tcaagtttga aggtgatacc     2640

cttgttaatc gtatcgagtt aaaaggtatt gattttaaag aagatggaaa cattctcgga     2700

cacaaactcg agtacaacta taactcacac aatgtataca tcacggcaga caaacaaaag     2760

aatggaatca aagctaactt caaaattcgc cacaacattg aagatggatc cgttcaacta     2820

gcagaccatt atcaacaaaa tactccaatt ggcgatggcc ctgtcctttt accagacaac     2880

cattacctgt cgacacaatc tgccctttcg aaagatccca acgaaaagcg tgaccacatg     2940

gtccttcttg agtttgtaac tgctgctggg attacacatg gcatggatga gctctacaaa     3000

ccgggtacag cgaccccagc aaccacgccg accactgcac cgaccgcggg taccggtaaa     3060

cttacatcag acttcgacaa cccaagatgg attggacgac acaagcatat gttcaatttc     3120

cttaatgtca accacaatgg aaaaatctct cttgacgaga tggtctacaa ggcatctgat     3180

attgtcatca ataaccttgg agcaacacct gagcaagcca aacgacacaa agatgctgta     3240

gaagccttct tcggaggagc tggaatgaaa tatggtgtgg aaactgattg gcctgcatat     3300

attgaaggat ggaaaaaatt ggctactgat gaattggaga aatacgccaa aaacgaacca     3360

acgctcatcc gtatatgggg tgatgctttg tttgacatcg ttgacaaagc ccaaaatgga     3420

gccattacac tggatgaatg gaaagcatac accaaagctg ctggtatcat ccaatcatca     3480

gaagattgcg aggaaacatt cagagtgtgc gatattgatg aaagtggaca actcgatgtt     3540

gatgagatga caagacaaca tttaggattt tggtacacca tggatcctgc ttgcgaaaag     3600

ctctacggtg gagctgtccc ctaa                                            3624


<210>  59
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  crGAP2.2

<400>  59

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Asn Asp Ala Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
            20                  25                  30          


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
        35                  40                  45              


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
    50                  55                  60                  


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
65                  70                  75                  80  


Thr Thr Phe Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
                85                  90                  95      


Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
            100                 105                 110         


Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
        115                 120                 125             


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
    130                 135                 140                 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
145                 150                 155                 160 


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
                165                 170                 175     


Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
            180                 185                 190         


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
        195                 200                 205             


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
    210                 215                 220                 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
225                 230                 235                 240 


Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr 
                245                 250                 255     


Lys Pro Gly Thr Ala Thr Pro Ala Thr Thr Pro Thr Thr Ala Pro Thr 
            260                 265                 270         


Ala Gly Thr Gly Lys Leu Thr Ser Asp Phe Asp Asn Pro Arg Trp Ile 
        275                 280                 285             


Gly Arg His Lys His Met Phe Asn Phe Leu Asn Val Asn His Asn Gly 
    290                 295                 300                 


Lys Ile Ser Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile 
305                 310                 315                 320 


Asn Asn Leu Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala 
                325                 330                 335     


Val Glu Ala Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr 
            340                 345                 350         


Asp Trp Pro Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu 
        355                 360                 365             


Leu Glu Lys Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly 
    370                 375                 380                 


Asp Ala Leu Phe Asp Ile Val Asp Lys Ala Gln Asn Gly Ala Ile Thr 
385                 390                 395                 400 


Leu Asp Glu Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser 
                405                 410                 415     


Ser Glu Asp Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser 
            420                 425                 430         


Gly Gln Leu Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp 
        435                 440                 445             


Tyr Thr Met Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
    450                 455                 460                 


Lys Asp Glu Leu 
465             


<210>  60
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  secuencia nucleotdica que codifica para crGAP2.2, optimizada 
       para expresin en clulas de ratn (crGAP3)

<400>  60
atgctcctct ctgtgcccct cctcctcggt ctcctgggac tggccgtagc caatgacgcc       60

tcaaaaggcg aagagctgtt cacaggcgtg gtccctatcc tcgtggaact cgatggagac      120

gtgaacggcc ataaattctc cgtatcaggc gagggggaag gagacgccac atatggaaag      180

ctgacactca aatttatctg caccacagga aaactgcctg tcccatggcc aaccctcgtg      240

acaaccttct catacggcgt gcaatgtttt agcagatatc cagaccacat gaaaaggcat      300

gacttcttta agagcgcaat gccagaagga tacgtccagg agaggaccat tagcttcaag      360

gacgatggca attataagac aagagccgag gtcaaattcg agggagacac tctcgtgaac      420

agaattgaac tgaaagggat cgattttaaa gaagatggca acatcctcgg acataagctc      480

gagtacaact acaactctca taatgtgtac ataaccgccg acaaacagaa gaacgggatc      540

aaagctaatt tcaagattag gcacaacata gaagacggct ccgtacagct ggctgaccac      600

tatcagcaga acacacccat aggggacggt cccgtgctcc tgccagataa tcactatctg      660

tccacacaat cagccctgag caaggaccct aacgagaaaa gagaccatat ggtcctgctg      720

gaatttgtaa cagctgcagg cattactcac ggaatggacg agctgtataa gcccggaaca      780

gccactccag ccactacacc caccaccgca cccactgcag gtaccgggaa actgaccagc      840

gacttcgata atccaagatg gatagggaga cacaagcata tgttcaattt tctgaatgtc      900

aaccacaatg gcaagatatc actggacgaa atggtctaca aggcatctga cattgtgatc      960

aacaatctcg gagctactcc tgagcaggca aagaggcaca aagacgccgt agaggccttt     1020

ttcggtggcg cagggatgaa atacggcgta gagactgatt ggcccgccta tattgagggg     1080

tggaagaaac tggcaaccga tgaactcgaa aaatacgcta aaaacgagcc tactctcata     1140

agaatctggg gcgatgctct cttcgatatt gtggataaag cacagaatgg agcaataaca     1200

ctggatgaat ggaaggcata cactaaggca gctggaatca tccaatcctc cgaggattgt     1260

gaagagacct tcagggtctg cgacatagac gaatctggcc agctcgacgt cgatgagatg     1320

acaaggcaac acctgggttt ttggtatacc atggaccctg cttgcgagaa actctacggc     1380

ggggctgtgc caaaggatga actgtag                                         1407


