                         SEQUENCE LISTING

<110>  FNDP
 
<120>  Diagnostic kit and its use in canc er

<130>  BPFNDP0034PC01

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1564
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1564)
<223>  TMEM45A

<220>
<221>  CDS
<222>  (314)..(1141)

<400>  1
gaagcacatc tggacagctg tgcggcctcc ttgcgggccg acgtcagccg agcacgtccc       60

ccacgtcctc tccttctcgc cacttattat ttattcgttt tcccaaagaa gcgactaggg      120

acccaagttt aaaaattcct ccccccactc aatgcgagac gtggccagat cccatccaac      180

acacggttta attttcatgg ggctctggga tcaaaagaac agaaacagca acaacaaaag      240

cccagccgct gtctgatttt aagctggcaa agtgggaaaa ataaagtgtt gagtaaacag      300

accaagttgg atc atg ggg aat ttc aga ggt cat gcc ctc cct gga acc         349
               Met Gly Asn Phe Arg Gly His Ala Leu Pro Gly Thr            
               1               5                   10                     

ttc ttt ttt att att ggt ctt tgg tgg tgt aca aag agt att ctg aag        397
Phe Phe Phe Ile Ile Gly Leu Trp Trp Cys Thr Lys Ser Ile Leu Lys           
        15                  20                  25                        

tat atc tgc aaa aag caa aag cga acc tgc tat ctt ggt tcc aaa aca        445
Tyr Ile Cys Lys Lys Gln Lys Arg Thr Cys Tyr Leu Gly Ser Lys Thr           
    30                  35                  40                            

tta ttc tat cga ttg gaa att ttg gag gga att aca ata gtt ggc atg        493
Leu Phe Tyr Arg Leu Glu Ile Leu Glu Gly Ile Thr Ile Val Gly Met           
45                  50                  55                  60            

gct tta act ggc atg gct ggg gag cag ttt att cct gga ggg ccc cat        541
Ala Leu Thr Gly Met Ala Gly Glu Gln Phe Ile Pro Gly Gly Pro His           
                65                  70                  75                

ctg atg tta tat gac tat aaa caa ggt cac tgg aat caa ctc ctg ggc        589
Leu Met Leu Tyr Asp Tyr Lys Gln Gly His Trp Asn Gln Leu Leu Gly           
            80                  85                  90                    

tgg cat cat ttc acc atg tat ttc ttc ttt ggg ctg ttg ggt gtg gca        637
Trp His His Phe Thr Met Tyr Phe Phe Phe Gly Leu Leu Gly Val Ala           
        95                  100                 105                       

gat atc tta tgt ttc acc atc agt tca ctt cct gtg tcc tta acc aag        685
Asp Ile Leu Cys Phe Thr Ile Ser Ser Leu Pro Val Ser Leu Thr Lys           
    110                 115                 120                           

tta atg ttg tca aat gcc tta ttt gtg gag gcc ttt atc ttc tac aac        733
Leu Met Leu Ser Asn Ala Leu Phe Val Glu Ala Phe Ile Phe Tyr Asn           
125                 130                 135                 140           

cac act cat ggc cgg gaa atg ctg gac atc ttt gtg cac cag ctg ctg        781
His Thr His Gly Arg Glu Met Leu Asp Ile Phe Val His Gln Leu Leu           
                145                 150                 155               

gtt ttg gtc gtc ttt ctg aca ggc ctc gtt gcc ttc cta gag ttc ctt        829
Val Leu Val Val Phe Leu Thr Gly Leu Val Ala Phe Leu Glu Phe Leu           
            160                 165                 170                   

gtt cgg aac aat gta ctt ctg gag cta ttg cgg tca agt ctc att ctg        877
Val Arg Asn Asn Val Leu Leu Glu Leu Leu Arg Ser Ser Leu Ile Leu           
        175                 180                 185                       

ctt cag ggg agc tgg ttc ttt cag att gga ttt gtc ctg tat ccc ccc        925
Leu Gln Gly Ser Trp Phe Phe Gln Ile Gly Phe Val Leu Tyr Pro Pro           
    190                 195                 200                           

agt gga ggt cct gca tgg gat ctg atg gat cat gaa aat att ttg ttt        973
Ser Gly Gly Pro Ala Trp Asp Leu Met Asp His Glu Asn Ile Leu Phe           
205                 210                 215                 220           

ctc acc ata tgc ttt tgt tgg cat tat gca gta acc att gtc atc gtt       1021
Leu Thr Ile Cys Phe Cys Trp His Tyr Ala Val Thr Ile Val Ile Val           
                225                 230                 235               

gga atg aat tat gct ttc att acc tgg ttg gtt aaa tct aga ctt aag       1069
Gly Met Asn Tyr Ala Phe Ile Thr Trp Leu Val Lys Ser Arg Leu Lys           
            240                 245                 250                   

agg ctc tgc tcc tca gaa gtt gga ctt ctg aaa aat gct gaa cga gaa       1117
Arg Leu Cys Ser Ser Glu Val Gly Leu Leu Lys Asn Ala Glu Arg Glu           
        255                 260                 265                       

caa gaa tca gaa gaa gaa atg tga ctttgatgag cttccagttt ttctagataa      1171
Gln Glu Ser Glu Glu Glu Met                                               
    270                 275                                               

accttttctt ttttacattg ttcttggttt tgtttctcga tcttttgttt ggagaacagc     1231

tggctaagga tgactctaag tgtactgttt gcatttccaa tttggttaaa gtatttgaat     1291

ttaaatattt tctttttagc tttgaaaata ttttgggtga tactttcatt ttgcacatca     1351

tgcacatcat ggtattcagg ggctagagtg atttttttcc agattatcta aagttggatg     1411

cccacactat gaaagaaata tttgttttat ttgccttata gatatgctca aggttactgg     1471

gcttgctact atttgtaact ccttgaccat ggaattatac ttgtttatct tgttgctgca     1531

atgagaaata aatgaatgta tgtattttgg tgc                                  1564


<210>  2
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Asn Phe Arg Gly His Ala Leu Pro Gly Thr Phe Phe Phe Ile 
1               5                   10                  15      


Ile Gly Leu Trp Trp Cys Thr Lys Ser Ile Leu Lys Tyr Ile Cys Lys 
            20                  25                  30          


Lys Gln Lys Arg Thr Cys Tyr Leu Gly Ser Lys Thr Leu Phe Tyr Arg 
        35                  40                  45              


Leu Glu Ile Leu Glu Gly Ile Thr Ile Val Gly Met Ala Leu Thr Gly 
    50                  55                  60                  


Met Ala Gly Glu Gln Phe Ile Pro Gly Gly Pro His Leu Met Leu Tyr 
65                  70                  75                  80  


Asp Tyr Lys Gln Gly His Trp Asn Gln Leu Leu Gly Trp His His Phe 
                85                  90                  95      


Thr Met Tyr Phe Phe Phe Gly Leu Leu Gly Val Ala Asp Ile Leu Cys 
            100                 105                 110         


Phe Thr Ile Ser Ser Leu Pro Val Ser Leu Thr Lys Leu Met Leu Ser 
        115                 120                 125             


Asn Ala Leu Phe Val Glu Ala Phe Ile Phe Tyr Asn His Thr His Gly 
    130                 135                 140                 


Arg Glu Met Leu Asp Ile Phe Val His Gln Leu Leu Val Leu Val Val 
145                 150                 155                 160 


Phe Leu Thr Gly Leu Val Ala Phe Leu Glu Phe Leu Val Arg Asn Asn 
                165                 170                 175     


Val Leu Leu Glu Leu Leu Arg Ser Ser Leu Ile Leu Leu Gln Gly Ser 
            180                 185                 190         


Trp Phe Phe Gln Ile Gly Phe Val Leu Tyr Pro Pro Ser Gly Gly Pro 
        195                 200                 205             


Ala Trp Asp Leu Met Asp His Glu Asn Ile Leu Phe Leu Thr Ile Cys 
    210                 215                 220                 


Phe Cys Trp His Tyr Ala Val Thr Ile Val Ile Val Gly Met Asn Tyr 
225                 230                 235                 240 


Ala Phe Ile Thr Trp Leu Val Lys Ser Arg Leu Lys Arg Leu Cys Ser 
                245                 250                 255     


Ser Glu Val Gly Leu Leu Lys Asn Ala Glu Arg Glu Gln Glu Ser Glu 
            260                 265                 270         


Glu Glu Met 
        275 


<210>  3
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA1

<400>  3
caauguacuu cuggagcua                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA2

<400>  4
gggaaaugcu ggacaucuu                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA3

<400>  5
aagcgaaccu gcuaucuug                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA4

<400>  6
uaaacaaggu cacuggaau                                                    19


