                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Dreyfuss, Gideon
       Wan, Lili
       Oh, Jung Min
       Pinto, Anna Maria
       Berg, Michael George
 
<120>  U1 SNRNP REGULATES GENE EXPRESSION AND MODULATES ONCOGENICITY

<130>  046483-6076-00-WO.602632

<150>  61/668,168
<151>  2012-07-05

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type 5' splice site recognition sequence of U1

<400>  1
acttacctg                                                                9


<210>  2
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1-A: mutated 5' splice site recognition sequence of U1

<400>  2
ctgctgttg                                                                9


<210>  3
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1-B: mutated 5' splice site recognition sequence of U1

<400>  3
tgaatggac                                                                9


<210>  4
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1-C: mutated 5' splice site recognition sequence of U1

<400>  4
ctacagatg                                                                9


<210>  5
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1-D: mutated 5' splice site recognition sequence of U1

<400>  5
cacccctac                                                                9


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  6
cctcttacct cagttacaat ttata                                             25


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  7
ggtatctccc ctgccaggta agtat                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  8
tgataagaac agatactaca cttga                                             25


<210>  9
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  9
aaccttctct cctttcatac aacac                                             25


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  10
tcgttatttt ccttactcat aagt                                              24


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  11
gttaacctct acgccaggta agtat                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  12
gataagaaca gatactacac tttga                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  13
aacttgctct ccttccaaac aacac                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  14
gattggtttt ccttactcat tagtt                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  15
ggatattttc ttcctaaaag gaatc                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  16
aataccacag tttattgaag actac                                             25


<210>  17
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  17
cgtatcgcct ccctcgcgcc atcagacgag tgcgtgctcg agcggccgcc cgggcaggt        59


<210>  18
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  18
ctatgcgcct tgccagcccg ctcagacgag tgcgtggcag cgtggtcgcg gccgaggt         58


<210>  19
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  19
cgtatcgcct ccctcgcgcc atcagacgct cgacagctcg agcggccgcc cgggcaggt        59


<210>  20
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  20
ctatgcgcct tgccagcccg ctcagacgct cgacaggcag cgtggtcgcg gccgaggt         58


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  21
cagtctgcca ttgtgacgtg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  22
ccaatgggag agccctaaac                                                   20


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  23
ctgcaatggg agttgggag                                                    19


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  24
gatgcgtttg attctgccca c                                                 21


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  25
gaggagctct ccaaactgat cagcg                                             25


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  26
ctgatcagcg gctttgacca                                                   20


<210>  27
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  27
cgagtatgag tcgactctag actgccg                                           27


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  28
ctctagactg ccgcgacgtg g                                                 21


<210>  29
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  29
ctgatctaga ggtaccggat cctttttttt tttttttttt                             40


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  30
ctgatctaga ggtaccggat cc                                                22


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  31
gctaactcag gggctgcata ggcac                                             25


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  32
cgtccttctc gccctccttc tcctc                                             25


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  33
gggtggcttt cttaatttgc atc                                               23


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  34
gatgatttcc attgctgcca cg                                                22


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  35
gtcttgaaac cacagcagtg cccag                                             25


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  36
ctcagcactg acggccttgt tgagt                                             25


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  37
cagacgatga gagaacaccc gatg                                              24


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  38
tggcacctct gtgggcctgt ggc                                               23


<210>  39
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  39
ctgttgcttc cactgcttca cattggc                                           27


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  40
aaggataagc agtgtgaaca ag                                                22


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  41
tctagatctc ccatcacggc                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  42
cagcagtgcc gaaagacata                                                   20


<210>  43
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  43
cgcctatcag tctgtccctg gactcc                                            26


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  44
ccttcctttg gtaaggaggc tgccc                                             25


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  45
ccggaattgc tgagtaagct gg                                                22


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  46
ggaaggcata tactggcaaa tgc                                               23


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  47
cctttagctc ctcgaattta acag                                              24


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  48
ccttgatgaa cttcctcaga ggac                                              24


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  49
ggttggtgat ggtggtactg g                                                 21


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  50
gatttcgcct tcactttcct gtc                                               23


<210>  51
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  51
gtgtggatgt agtacacatg gatgaaaac                                         29


<210>  52
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  52
ttattgtaca ccaggacctt ctccacag                                          28


<210>  53
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  53
caactatggc tgtggagaag gtcctggt                                          28


<210>  54
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  54
tctgacctgg agacgaaact gtagagtatc t                                      31


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  55
caacagacat tgctgaagaa ac                                                22


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  56
attttggatg actgcggc                                                     18


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  57
ctttaggagc tgctgtcgat a                                                 21


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  58
gctcctacct cttccaagca g                                                 21


<210>  59
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  59
acaaaacaca gcccccagc                                                    19


<210>  60
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  60
tggtgtgaat gtcagtgtga atgc                                              24


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  61
gcaagttgaa ggaagcagca gg                                                22


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  62
tgatcacgaa ggtggttttc c                                                 21


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  63
gcacatccgg agtgcaatg                                                    19


