                         SEQUENCE LISTING

<110>  CHILDREN'S MEDICAL CENTER CORPORATION
       Watnick, Paula
 
<120>  THE BACTERIAL BIOFILM MATRIX AS A PLATFORM FOR PROTEIN DELIVERY

<130>  C1233.70056WO00

<140>  PCT/US2013/049337
<141>  2013-07-03

<150>  61/780,079
<151>  2013-03-13

<150>  61/668,417
<151>  2012-07-05

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Lys Gln Thr Lys Thr Leu Thr Ala Ile Ser Val Leu Ala Leu Ser 
1               5                   10                  15      


His Leu Met Thr Gln Ser Thr Ala Phe Ala Ser Ser Ser Ser Asp Ile 
            20                  25                  30          


Gln Thr Lys Leu Lys Trp Ser Trp Ser Thr Ser Val Phe His Pro Glu 
        35                  40                  45              


Ser Asn Gln Val Met Ala Ala Pro Ile Val Val Gln Leu Asn Asp Asp 
    50                  55                  60                  


Asn Gly Asp Gly Lys Ile Asp Glu Lys Asp Val Ala Asp Ile Ile Val 
65                  70                  75                  80  


Val Thr Phe Glu Gly Asn Lys Tyr Ala Asn Gly Gly Tyr Ile Arg Ala 
                85                  90                  95      


Leu Ser Gly Val Asp Gly Ser Glu Leu Trp Ser Tyr Ser Asn Gly Gly 
            100                 105                 110         


Val Ile Ala Asp Ala Arg Tyr Ala Pro Ala Ala Ala Asp Leu Asp Gly 
        115                 120                 125             


Asp Gly Leu Ile Glu Ile Val Ser Thr Ser Ala Leu Thr Pro Tyr Ile 
    130                 135                 140                 


Asn Ile Leu Asp His Gln Gly Asn Ile Lys Lys Gln Leu Leu Lys Ser 
145                 150                 155                 160 


Ala Ser Gly Trp Arg Ser Val Gly Asp Ile Ala Leu Ala Asp Ile Asn 
                165                 170                 175     


Gly Asp Gly Asn Ile Glu Ile Leu Ala Ala Asp Gly Val Tyr Ser Tyr 
            180                 185                 190         


Glu Ser Gly Leu Leu Phe Ser His Asp Trp Ala Pro Ser Ser Ile Ala 
        195                 200                 205             


Phe Asp Ser Asn Gly Asp Gly Gln Arg Glu Val Phe Ala Asn Gly Thr 
    210                 215                 220                 


Leu Tyr Gln Asn Asn Gly Ala Tyr Leu Trp Gln Tyr Gln Ala Asn Asp 
225                 230                 235                 240 


Thr Val Trp Phe Ser Ser Val Ala Asn Leu Asp Gly Asp Asp Lys Pro 
                245                 250                 255     


Glu Leu Val Val Ser Val Pro Ala Ser Leu Ser Thr Pro Glu Asn Ser 
            260                 265                 270         


Glu Ile Ala Val Leu Glu His Asp Gly Ser Val Lys Trp Arg Val Asn 
        275                 280                 285             


Asn Leu Ser Asn Pro Gly Gly Ser Val Gln Ala Val Ser Ser Phe Leu 
    290                 295                 300                 


Gly Lys Pro Ser Ser Ser Ala Thr Thr Val Asp Ala Gln Ser Ala Val 
305                 310                 315                 320 


Tyr Gly Tyr Thr Asp Trp Ala His Gln Gln Arg Val Leu Ala Glu Asn 
                325                 330                 335     


His Gln Leu Ala Ile Arg Ser Gly Ala Val Val Asp Ala Ile Gly Ala 
            340                 345                 350         


Asn Ser Gln Asn Met Ile Gly Gly Ser Gly Gly Ser Leu Ser Thr Ile 
        355                 360                 365             


Asp Thr Ser Lys Val Arg Ala Ile Asp Val Thr Tyr Gly Lys Asn Lys 
    370                 375                 380                 


Tyr Thr Trp Lys Tyr Gly Val Leu Glu Met Ser Phe Thr Leu Asp Asn 
385                 390                 395                 400 


Gly Ala Lys Val Thr Val Gly Ser Lys Asp Ser Ala Phe Thr Tyr Leu 
                405                 410                 415     


Gly Leu Glu Trp Lys Thr Lys Thr Val Pro Tyr Leu Gly Val Glu Trp 
            420                 425                 430         


Arg Thr Lys Thr Val Ser Tyr Trp Phe Phe Gly Trp His Thr Lys Gln 
        435                 440                 445             


Val Ala Tyr Leu Ala Pro Val Trp Lys Glu Lys Thr Ile Pro Tyr Ala 
    450                 455                 460                 


Val Pro Val Thr Leu Ser Lys Ser Thr Thr Val Arg Tyr Asp Ile Pro 
465                 470                 475                 480 


Gln Gly Ser Gln Leu Leu Gly Met Asn Val Trp Ser Lys Glu Lys His 
                485                 490                 495     


Leu Phe Lys His Lys Gln Gln Val Asn Ala Val Gln Phe Leu Val Gly 
            500                 505                 510         


Lys Val Thr Ala Asp Gln Ser His Met Gly Ile Val Tyr Ala Gly Tyr 
        515                 520                 525             


Tyr Ala Val Asp Met Tyr Asp Ala Gln Gly Asn Lys Val Trp Ser Val 
    530                 535                 540                 


Ala Asn Asp Asp Leu Asn Ser Gly Lys Ile Gly Val Ser Ala Tyr Asp 
545                 550                 555                 560 


Phe Thr Gly Asp Gly Ile Asp Glu Val Leu Val Gln Asp Arg Leu Arg 
                565                 570                 575     


Met Arg Ile Leu Asp Gly Gln Thr Gly Arg Val Met Gly Ile Ile Ala 
            580                 585                 590         


Asn Ser Ser Gly Thr Leu Trp Glu Tyr Pro Val Val Ala Asp Leu Glu 
        595                 600                 605             


Gly Asn Asn Asn Ala Ser Leu Ile Met Val Ala Asn Asp Tyr Asp Arg 
    610                 615                 620                 


Glu Ser Gln Val Asn His Gly Val Phe Val Tyr Glu Ser Ala Asn Pro 
625                 630                 635                 640 


Ser Lys Pro Trp Arg Asn Ala Thr Arg Ile Trp Asn Gln Tyr Ala Phe 
                645                 650                 655     


Asn Phe Ser Asp Ile Asn Ala Asn Gly Thr Ile Pro Thr Asn Ala Gln 
            660                 665                 670         


Pro Ser Trp Leu Thr His Asn Ser Phe Arg Ser Ala Thr Ile Arg Val 
        675                 680                 685             


Pro Leu Lys 
    690     


<210>  2
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Ser Asn Phe Lys Gly Ser Ile Met Asn Lys Arg His Tyr Tyr Leu 
1               5                   10                  15      


Ala Ser Cys Leu Ala Leu Leu Phe Ser Thr Ala Ser Tyr Ala Glu Val 
            20                  25                  30          


Asp Cys Glu Leu Gln Pro Val Ile Glu Ala Asn Leu Ser Leu Asn Gln 
        35                  40                  45              


Asn Gln Leu Ala Ser Asn Gly Gly Tyr Ile Ser Ser Gln Leu Gly Ile 
    50                  55                  60                  


Arg Asn Glu Ser Cys Glu Thr Val Lys Phe Lys Tyr Trp Leu Ser Ile 
65                  70                  75                  80  


Lys Gly Pro Glu Gly Ile Tyr Phe Pro Ala Lys Ala Val Val Gly Val 
                85                  90                  95      


Asp Thr Ala Gln Gln Glu Ser Asp Ala Leu Thr Asp Gly Arg Met Leu 
            100                 105                 110         


Asn Val Thr Arg Gly Phe Trp Val Pro Glu Tyr Met Ala Asp Gly Lys 
        115                 120                 125             


Tyr Thr Val Ser Leu Gln Val Val Ala Glu Asn Gly Lys Val Phe Lys 
    130                 135                 140                 


Ala Asn Gln Glu Phe Val Lys Gly Val Asp Leu Asn Ser Leu Pro Glu 
145                 150                 155                 160 


Leu Asn Gly Leu Thr Ile Asp Ile Lys Asn Gln Phe Gly Ile Asn Ser 
                165                 170                 175     


Val Glu Ser Thr Gly Gly Phe Val Pro Phe Thr Val Asp Leu Asn Asn 
            180                 185                 190         


Gly Arg Glu Gly Glu Ala Asn Val Glu Phe Trp Met Thr Ala Val Gly 
        195                 200                 205             


Pro Asp Gly Leu Ile Ile Pro Val Asn Ala Arg Glu Lys Trp Val Ile 
    210                 215                 220                 


Ala Ser Gly Asp Thr Tyr Ser Lys Val Arg Gly Ile Asn Phe Asp Lys 
225                 230                 235                 240 


Ser Tyr Pro Ala Gly Glu Tyr Thr Ile Asn Ala Gln Val Val Asp Ile 
                245                 250                 255     


Val Ser Gly Glu Arg Val Glu Gln Ser Met Thr Val Val Lys Lys 
            260                 265                 270     


<210>  3
<211>  957
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Thr Ser His Tyr Ile Ala Leu Ala Val Gly Leu Leu Ser Leu Ser 
1               5                   10                  15      


Ser Asn Val Val Gln Ala Thr Thr Asn Glu Ala Glu Gly Cys Ile Ile 
            20                  25                  30          


Ser Arg Leu Asn Gly Glu Lys Tyr Cys Leu Lys Val Gly Glu Arg Ser 
        35                  40                  45              


Gly Tyr Ser Leu Pro Ser Trp Ile Tyr Ala His Pro Val Asp Val Gln 
    50                  55                  60                  


Ala Pro Ser Gly Val Ser Val Met Leu Ser Asp Trp Asp Asn Leu Ser 
65                  70                  75                  80  


Tyr Asn Arg Leu Ala Val Phe Asp Arg Tyr Thr Gly Asn Glu Asp Leu 
                85                  90                  95      


Lys Asn Val Lys Ala Tyr Asn Gly Ala Tyr Leu Asp Phe Ser Lys Pro 
            100                 105                 110         


Arg Ser Met Arg Val Leu Ala Ser Glu Thr Tyr Pro Glu Ala Cys Ile 
        115                 120                 125             


Val Ser Arg Gln Thr Gly Glu Arg Phe Cys Leu Lys Glu Gly Glu Arg 
    130                 135                 140                 


Ser Gly Tyr Ser Leu Pro Ala Tyr Ile Tyr Gly His Glu Val Asp Val 
145                 150                 155                 160 


Glu Ala Pro Leu Gly Leu Gly Val Met Leu Ser Asp Trp Asp Asn Leu 
                165                 170                 175     


Ser Tyr Asn Arg Leu Ala Val Phe Gly Gly Asn Thr Gln Asn Glu Gln 
            180                 185                 190         


Met Arg Ala Val Lys Ala Tyr Asn Gly Glu Thr Leu Asp Phe Ser Lys 
        195                 200                 205             


Pro Arg Ser Met Arg Val Val Pro Tyr Asp Gly Asp Ser Ser Ala Leu 
    210                 215                 220                 


Asn Met Lys Leu Lys Trp Ser Trp Gln Gly Ser Ala Phe Gln Pro Asn 
225                 230                 235                 240 


Ser Asn Gln Val Met Val Thr Pro Ile Val Ala Gln Leu Asn Asp Asp 
                245                 250                 255     


Asn Gly Asp Gly Lys Ile Asp Glu Lys Asp Val Ala Asp Leu Ile Val 
            260                 265                 270         


Val Thr Phe Glu Gly Asn Lys Tyr Ala Asn Gly Gly Leu Val Arg Ala 
        275                 280                 285             


Leu Ser Gly Val Asp Gly Ser Glu Leu Trp Ser Tyr Ala Asn Gly Gly 
    290                 295                 300                 


Val Ile Ala Asp Ala Arg Tyr Ser Pro Ala Val Gly Asp Leu Asp Gly 
305                 310                 315                 320 


Asp Gly Ile Val Glu Ile Val Thr Thr Asn Asn Arg Asp Gln Phe Ile 
                325                 330                 335     


Thr Ile Leu Asp Asn Gln Gly Asn Ile Lys Lys Gln Ile Pro Thr Thr 
            340                 345                 350         


Glu Ser Gly Trp Arg Ile Val Gly Asp Ile Thr Leu Ala Asp Leu Asp 
        355                 360                 365             


His Asp Gly Ser Val Glu Ile Leu Ala Ala Asp Gly Val Tyr Asn Tyr 
    370                 375                 380                 


His Ser Gly Leu Val Phe Asn His Pro Trp Ala Pro Ser Ser Ile Asn 
385                 390                 395                 400 


Val Asp Val Asp Gly Asp Gln Gln Gln Glu Val Phe Ser Gly Gly Thr 
                405                 410                 415     


Leu Phe Gln Asn Asn Gly Ala Ile Asn Trp Gln Tyr Gln Ala Asn Asp 
            420                 425                 430         


Ala Val Trp Phe Ser Ser Leu Val Asn Leu Asp Asn Asp Ala Glu Pro 
        435                 440                 445             


Glu Ile Val Ala Ser Val Pro Ala Thr Phe Ala Thr Gly Asp Asn Ala 
    450                 455                 460                 


Arg Phe Ala Val Leu Glu His Asp Gly Thr Ile Lys Trp Glu Ile Asn 
465                 470                 475                 480 


Asn Thr Ala Asn Pro Gly Gly Gly Val Gln Ala Val Ser Asn Phe Leu 
                485                 490                 495     


Gly Lys Ala Gln Ala Val Glu Thr Ser Glu Phe Ser Lys Val Tyr Gly 
            500                 505                 510         


Tyr Gln Pro Asn Asn Asn Pro Ala Ser Ile Ala Leu Ala Val Asp Gly 
        515                 520                 525             


Lys Ile Ser Val Arg Ser Gly Phe Ala Ile Asp Ala Ile Gly Ala Ser 
    530                 535                 540                 


Ala Ser Thr Leu Val Gly Gly Thr Gly Gly Asn Leu Asn Ala Ala Val 
545                 550                 555                 560 


Asn Val Lys Asp Ile Lys Ala Ile Asp Leu Thr Trp Gly Lys Tyr Tyr 
                565                 570                 575     


Trp Gly Gly Tyr His Leu Leu Ala Leu Asp Phe Arg Met Ser Asn Gly 
            580                 585                 590         


Ser Val Ile Ser Met Gly Ser Lys Asn Tyr Ala Tyr Ser Lys Gln Thr 
        595                 600                 605             


Glu Arg Phe Thr Val Pro Ala Gly Ser Arg Ile Lys Gly Ile Lys Ala 
    610                 615                 620                 


Trp Thr Ala Gly Trp Leu Leu Asp Gly Val Gln Phe Glu Leu Ala Thr 
625                 630                 635                 640 


Gln Asn Gly Thr Asn Asp Leu Asp Val Lys Gly Ile Val Tyr Ala Gly 
                645                 650                 655     


Tyr Ala Ala Val Asp Met Tyr Asn Ser Lys Gly Glu Arg Val Trp Ser 
            660                 665                 670         


Val Ala Asn Asp Asp Thr Gly Ser Gly Lys Ile Gly Val Ser Ala Tyr 
        675                 680                 685             


Asp Phe Asp Asn Asp Gly Ile Asp Glu Val Leu Val Gln Asp His Ala 
    690                 695                 700                 


Arg Val Arg Val Leu Asp Gly Lys Thr Gly Lys Glu Arg Ala Ser Leu 
705                 710                 715                 720 


Ala His Ser Thr Ala Thr Leu Trp Glu Tyr Pro Ile Val Val Asp Leu 
                725                 730                 735     


Glu Gly Asp Asn Asn Ala Glu Leu Ile Val Ala Ala Asn Asp Phe Asp 
            740                 745                 750         


Arg Gln Tyr Ser Ile Asn His Gly Val Tyr Val Tyr Gln Ser Ala Asp 
        755                 760                 765             


Ser Ser Lys Pro Trp Lys Asn Ala Thr Arg Ile Trp Asn Gln His Ala 
    770                 775                 780                 


Phe His Leu Thr Asn Ile Asn Gln Asp Gly Thr Leu Pro Thr Phe Val 
785                 790                 795                 800 


Glu Pro Ser Trp Leu Ser His Asn Thr Tyr Arg Ser Ser Thr Leu Arg 
                805                 810                 815     


Ala Ala Val Gly Gly Glu Ser Pro Ile Phe Gly Tyr Ser Asn Thr Gln 
            820                 825                 830         


Gln Ser Gln Arg Val Val Thr Ala Asp Asn Leu Met Tyr Leu Arg Ser 
        835                 840                 845             


Gly Phe Ala Ile Asp Ala Ile Gly Thr Thr Val Asn Asn Leu Val Gly 
    850                 855                 860                 


Gly Pro Val Gln Gly Thr Asn Gly Gly Val Leu Arg Ala Pro Ile Ala 
865                 870                 875                 880 


Leu Asp Gln Leu Gln Ser Val Glu Val Thr Ser Gly Leu Tyr Asn Trp 
                885                 890                 895     


Gly Gly Tyr His Ile Val Ala Ile Lys Phe Thr Met Lys Asp Gly Ser 
            900                 905                 910         


Ser Val Leu Leu Gly Ser Thr His Tyr Ala Ser Asn Lys Lys Val Glu 
        915                 920                 925             


Thr Tyr Thr Val Pro Gln Gly Lys Arg Ile Lys Gln Ile Asn Val Trp 
    930                 935                 940                 


Thr Gly Gly Trp Leu Val Glu Gly Phe Gln Phe Val Tyr 
945                 950                 955         


<210>  4
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Pro Lys Leu Asn Arg Cys Ala Ile Ala Ile Phe Thr Ile Leu Ser 
1               5                   10                  15      


Ala Ile Ser Ser Pro Thr Leu Leu Ala Asn Ile Asn Glu Pro Ser Gly 
            20                  25                  30          


Glu Ala Ala Asp Ile Ile Ser Gln Val Ala Asp Ser His Ala Ile Lys 
        35                  40                  45              


Tyr Tyr Asn Ala Ala Asp Trp Gln Ala Glu Asp Asn Ala Leu Pro Ser 
    50                  55                  60                  


Leu Ala Glu Leu Arg Asp Leu Val Ile Asn Gln Gln Lys Arg Val Leu 
65                  70                  75                  80  


Val Asp Phe Ser Gln Ile Ser Asp Ala Glu Gly Gln Ala Glu Met Gln 
                85                  90                  95      


Ala Gln Phe Arg Lys Ala Tyr Gly Val Gly Phe Ala Asn Gln Phe Ile 
            100                 105                 110         


Val Ile Thr Glu His Lys Gly Glu Leu Leu Phe Thr Pro Phe Asp Gln 
        115                 120                 125             


Ala Glu Glu Val Asp Pro Gln Leu Leu Glu Ala Pro Arg Thr Ala Arg 
    130                 135                 140                 


Leu Leu Ala Arg Ser Gly Phe Ala Ser Pro Ala Pro Ala Asn Ser Glu 
145                 150                 155                 160 


Thr Asn Thr Leu Pro His Val Ala Phe Tyr Ile Ser Val Asn Arg Ala 
                165                 170                 175     


Ile Ser Asp Glu Glu Cys Thr Phe Asn Asn Ser Trp Leu Trp Lys Asn 
            180                 185                 190         


Glu Lys Gly Ser Arg Pro Phe Cys Lys Asp Ala Asn Ile Ser Leu Ile 
        195                 200                 205             


Tyr Arg Val Asn Leu Glu Arg Ser Leu Gln Tyr Gly Ile Val Gly Ser 
    210                 215                 220                 


Ala Thr Pro Asp Ala Lys Ile Val Arg Ile Ser Leu Asp Asp Asp Ser 
225                 230                 235                 240 


Thr Gly Ala Gly Ile His Leu Asn Asp Gln Leu Gly Tyr Arg Gln Phe 
                245                 250                 255     


Gly Ala Ser Tyr Thr Thr Leu Asp Ala Tyr Phe Arg Glu Trp Ser Thr 
            260                 265                 270         


Asp Ala Ile Ala Gln Asp Tyr Arg Phe Val Phe Asn Ala Ser Asn Asn 
        275                 280                 285             


Lys Ala Gln Ile Leu Lys Thr Phe Pro Val Asp Asn Ile Asn Glu Lys 
    290                 295                 300                 


Phe Glu Arg Lys Glu Val Ser Gly Phe Glu Leu Gly Val Thr Gly Gly 
305                 310                 315                 320 


Val Glu Val Ser Gly Asp Gly Pro Lys Ala Lys Leu Glu Ala Arg Ala 
                325                 330                 335     


Ser Tyr Thr Gln Ser Arg Trp Leu Thr Tyr Asn Thr Gln Asp Tyr Arg 
            340                 345                 350         


Ile Glu Arg Asn Ala Lys Asn Ala Gln Ala Val Ser Phe Thr Trp Asn 
        355                 360                 365             


Arg Gln Gln Tyr Ala Thr Ala Glu Ser Leu Leu Asn Arg Ser Thr Asp 
    370                 375                 380                 


Ala Leu Trp Val Asn Thr Tyr Pro Val Asp Val Asn Arg Ile Ser Pro 
385                 390                 395                 400 


Leu Ser Tyr Ala Ser Phe Val Pro Lys Met Asp Val Ile Tyr Lys Ala 
                405                 410                 415     


Ser Ala Thr Glu Thr Gly Ser Thr Asp Phe Ile Ile Asp Ser Ser Val 
            420                 425                 430         


Asn Ile Arg Pro Ile Tyr Asn Gly Ala Tyr Lys His Tyr Tyr Val Val 
        435                 440                 445             


Gly Ala His Gln Phe Tyr His Gly Phe Glu Asp Thr Pro Arg Arg Arg 
    450                 455                 460                 


Ile Thr Lys Ser Ala Ser Phe Thr Val Asp Trp Asp His Pro Val Phe 
465                 470                 475                 480 


Thr Gly Gly Arg Pro Val Asn Leu Gln Leu Ala Ser Phe Asn Asn Arg 
                485                 490                 495     


Cys Ile Gln Val Asp Ala Gln Gly Arg Leu Ala Ala Asn Thr Cys Asp 
            500                 505                 510         


Ser Gln Gln Ser Ala Gln Ser Phe Ile Tyr Asp Gln Leu Gly Arg Tyr 
        515                 520                 525             


Val Ser Ala Ser Asn Thr Lys Leu Cys Leu Asp Gly Glu Ala Leu Asp 
    530                 535                 540                 


Ala Leu Gln Pro Cys Asn Gln Asn Leu Thr Gln Arg Trp Glu Trp Arg 
545                 550                 555                 560 


Lys Gly Thr Asp Glu Leu Thr Asn Val Tyr Ser Gly Glu Ser Leu Gly 
                565                 570                 575     


His Asp Lys Gln Thr Gly Glu Leu Gly Leu Tyr Ala Ser Ser Asn Asp 
            580                 585                 590         


Ala Val Ser Leu Arg Thr Ile Thr Ala Tyr Thr Asp Val Phe Asn Ala 
        595                 600                 605             


Gln Glu Ser Ser Pro Ile Leu Gly Tyr Thr Gln Gly Lys Met Asn Gln 
    610                 615                 620                 


Gln Arg Val Gly Gln Asp His Arg Leu Tyr Val Arg Ala Gly Ala Ala 
625                 630                 635                 640 


Ile Asp Ala Leu Gly Ser Ala Ser Asp Leu Leu Val Gly Gly Asn Gly 
                645                 650                 655     


Gly Ser Leu Ser Ser Val Asp Leu Ser Gly Val Lys Ser Ile Thr Ala 
            660                 665                 670         


Thr Ser Gly Asp Phe Gln Tyr Gly Gly Gln Gln Leu Val Ala Leu Thr 
        675                 680                 685             


Phe Thr Tyr Gln Asp Gly Arg Gln Gln Thr Val Gly Ser Lys Ala Tyr 
    690                 695                 700                 


Val Thr Asn Ala His Glu Asp Arg Phe Asp Leu Pro Ala Ala Ala Lys 
705                 710                 715                 720 


Ile Thr Gln Leu Lys Ile Trp Ser Asp Asp Trp Leu Val Lys Gly Val 
                725                 730                 735     


Gln Phe Asp Leu Asn 
            740     


<210>  5
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Ile Lys Leu Lys Phe Gly Val Phe Phe Thr Val Leu Leu Ser Ser 
1               5                   10                  15      


Ala Tyr Ala His Gly Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu 
            20                  25                  30          


Tyr His Asn Thr Gln Ile Tyr Thr Leu Asn Asp Lys Ile Phe Ser Tyr 
        35                  40                  45              


Thr Glu Ser Leu Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys 
    50                  55                  60                  


Asn Gly Ala Ile Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp 
65                  70                  75                  80  


Ser Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala 
                85                  90                  95      


Tyr Leu Thr Glu Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys 
            100                 105                 110         


Thr Pro His Ala Ile Ala Ala Ile Ser Met Ala Asn 
        115                 120                 


<210>  6
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Asn Ile Phe Lys Gln Thr Cys Val Gly Ala Phe Ala Val Ile Phe 
1               5                   10                  15      


Gly Ala Thr Ser Ile Ala Pro Thr Met Ala 
            20                  25      


<210>  7
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Lys Phe Leu Gln Gln Met Arg Lys Leu Phe Gly Leu Ala Ala Lys 
1               5                   10                  15      


Phe Pro Ala Arg Leu Thr Ile Ala Val Ile Gly Thr Ala Leu Leu Ala 
            20                  25                  30          


Gly Leu Val Gly Val Val Gly Asp Thr Ala Ile Ala Val Ala 
        35                  40                  45      


<210>  8
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Asn Pro Met Thr Arg Arg His Thr Trp Thr Arg Leu Ala Cys Ala 
1               5                   10                  15      


Leu Ser Leu Gly Val Ala Ala Phe Ala Ala Gln Ala 
            20                  25              


<210>  9
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Ser Thr Phe Lys Leu Leu Lys Thr Leu Thr Ser Arg Arg Gln Val 
1               5                   10                  15      


Leu Lys Thr Gly Leu Ala Ala Leu Thr Leu Ser Gly Met Ser His Ala 
            20                  25                  30          


Val Ala 
        


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Lys Leu Ala Ala Cys Phe Leu Thr Leu Leu Pro Gly Phe Ala Val 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met His Pro Ser Thr Ser Arg Pro Ser Arg Arg Thr Leu Leu Thr Ala 
1               5                   10                  15      


Thr Ala Gly Ala Ala Leu Ala Ala Ala Thr Leu Val Pro Gly Thr Ala 
            20                  25                  30          


His Ala Ser Ser Gly Gly Arg 
        35                  


<210>  12
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Met Arg Phe Arg His Lys Ala Ala Ala Leu Ala Ala Thr Leu Ala Leu 
1               5                   10                  15      


Pro Leu Ala Gly Leu Val Gly Leu Ala Ser Pro Ala Gln Ala 
            20                  25                  30  


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Val Phe Leu Arg Arg Ile Arg Val Ile Val Ile Arg 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Val Phe Trp Arg Arg Ile Arg Val Trp Val Ile Arg 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Val Gln Leu Arg Ala Ile Arg Val Arg Val Ile Arg 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Val Gln Leu Arg Arg Ile Arg Val Trp Val Ile Arg 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Val Gln Trp Arg Ala Ile Arg Val Arg Val Ile Arg 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Val Gln Trp Arg Arg Ile Arg Val Trp Val Ile Arg 
1               5                   10          


<210>  20
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Gly Arg Phe Lys Arg Phe Arg Lys Lys Phe Lys Lys Leu Phe Lys Lys 
1               5                   10                  15      


Leu Ser Pro Val Ile Pro Leu Leu His Leu Gly 
            20                  25          


<210>  21
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys 
1               5                   10                  15      


Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
            20                  25              


<210>  22
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Arg Leu Ala Arg Ile Val Val Ile Arg Val Ala Arg Leu Leu Gly Asp 
1               5                   10                  15      


Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu Phe Lys Arg Ile 
            20                  25                  30          


Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val Pro Arg Thr Glu 
        35                  40                  45              


Ser 
    


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Val Gln Leu Arg Ile Arg Val Ala Val Ile Arg Ala 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Val Gln Arg Trp Leu Ile Val Trp Arg Ile Arg Lys 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Val Arg Leu Ile Val Ala Val Arg Ile Trp Arg Arg 
1               5                   10          


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Ile Trp Val Ile Trp Arg Arg 
1               5           


<210>  27
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is dehydrobutyrine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is dehydroalanine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is 2-aminobutyric acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is 2-aminobutyric acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa is 2-aminobutyric acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa is 2-aminobutyric acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa is dehydroalanine

<400>  27

Ile Xaa Ala Ile Xaa Leu Ala Xaa Pro Gly Ala Lys Xaa Gly Ala Leu 
1               5                   10                  15      


Met Gly Ala Asn Met Lys Xaa Ala Xaa Ala Asn Ala Ser Ile Asn Val 
            20                  25                  30          


Xaa Leu 
        


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Val Xaa Xaa Arg Xaa Ile Arg Val Xaa Val Ile Arg 
1               5                   10          


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Ile Leu Lys Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Ile Leu Pro Trp Lys Lys Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Ile Leu Lys Trp Lys Trp Pro Trp Trp Lys Trp Arg Arg 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Ile Leu Arg Trp Lys Trp Arg Trp Trp Arg Trp Arg Arg 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is RbmA-CtxB-I-

<400>  33

Xaa Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is RbmC-I-

<400>  34

Xaa Leu Lys Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  35
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Met Ser Asn Phe Lys Gly Ser Ile Met Asn Lys Arg His Tyr Tyr Leu 
1               5                   10                  15      


Ala Ser Cys Leu Ala Leu Leu Phe Ser Thr Ala Ser Tyr Ala Glu Val 
            20                  25                  30          


Asp Cys Glu Leu Gln Pro Val Ile Glu Ala Asn Leu Ser Leu Asn Gln 
        35                  40                  45              


Asn Gln Leu Ala Ser Asn Gly Gly Tyr Ile Ser Ser Gln Leu Gly Ile 
    50                  55                  60                  


Arg Asn Glu Ser Cys Glu Thr Val Lys Phe Lys Tyr Trp Leu Ser Ile 
65                  70                  75                  80  


Lys Gly Pro Glu Gly Ile Tyr Phe Pro Ala Lys Ala Val Val Gly Val 
                85                  90                  95      


Asp Thr Ala Gln Gln Glu Ser Asp Ala Leu Thr Asp Gly Arg Met Leu 
            100                 105                 110         


Asn Val Thr Arg Gly Phe Trp Val Pro Glu Tyr Met Ala Asp Gly Lys 
        115                 120                 125             


Tyr Thr Val Ser Leu Gln Val Val Ala Glu Asn Gly Lys Val Phe Lys 
    130                 135                 140                 


Ala Asn Gln Glu Phe Val Lys Gly Val Asp Leu Asn Ser Leu Pro Glu 
145                 150                 155                 160 


Leu Asn Gly Leu Thr Ile Asp Ile Lys Asn Gln Phe Gly Ile Asn Ser 
                165                 170                 175     


Val Glu Ser Thr Gly Gly Phe Val Pro Phe Thr Val Asp Leu Asn Asn 
            180                 185                 190         


Gly Arg Glu Gly Glu Ala Asn Val Glu Phe Trp Met Thr Ala Val Gly 
        195                 200                 205             


Pro Asp Gly Leu Ile Ile Pro Val Asn Ala Arg Glu Lys Trp Val Ile 
    210                 215                 220                 


Ala Ser Gly Asp Thr Tyr Ser Lys Val Arg Gly Ile Asn Phe Asp Lys 
225                 230                 235                 240 


Ser Tyr Pro Ala Gly Glu Tyr Thr Ile Asn Ala Gln Val Val Asp Ile 
                245                 250                 255     


Val Ser Gly Glu Arg Val Glu Gln Ser Met Thr Val Val Lys Lys Asp 
            260                 265                 270         


Tyr Lys Asp Asp Asp Asp Lys 
        275                 


<210>  36
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Met Ser Asn Phe Lys Gly Ser Ile Met Asn Lys Arg His Tyr Tyr Leu 
1               5                   10                  15      


Ala Ser Cys Leu Ala Leu Leu Phe Ser Thr Ala Ser Tyr Ala Glu Val 
            20                  25                  30          


Asp Cys Glu Leu Gln Pro Val Ile Glu Ala Asn Leu Ser Leu Asn Gln 
        35                  40                  45              


Asn Gln Leu Ala Ser Asn Gly Gly Tyr Ile Ser Ser Gln Leu Gly Ile 
    50                  55                  60                  


Arg Asn Glu Ser Cys Glu Thr Val Lys Phe Lys Tyr Trp Leu Ser Ile 
65                  70                  75                  80  


Lys Gly Pro Glu Gly Ile Tyr Phe Pro Ala Lys Ala Val Val Gly Val 
                85                  90                  95      


Asp Thr Ala Gln Gln Glu Ser Asp Ala Leu Thr Asp Gly Arg Met Leu 
            100                 105                 110         


Asn Val Thr Arg Gly Phe Trp Val Pro Glu Tyr Met Ala Asp Gly Lys 
        115                 120                 125             


Tyr Thr Val Ser Leu Gln Val Val Ala Glu Asn Gly Lys Val Phe Lys 
    130                 135                 140                 


Ala Asn Gln Glu Phe Val Lys Gly Val Asp Leu Asn Ser Leu Pro Glu 
145                 150                 155                 160 


Leu Asn Gly Leu Thr Ile Asp Ile Lys Asn Gln Phe Gly Ile Asn Ser 
                165                 170                 175     


Val Glu Ser Thr Gly Gly Phe Val Pro Phe Thr Val Asp Leu Asn Asn 
            180                 185                 190         


Gly Arg Glu Gly Glu Ala Asn Val Glu Phe Trp Met Thr Ala Val Gly 
        195                 200                 205             


Pro Asp Gly Leu Ile Ile Pro Val Asn Ala Arg Glu Lys Trp Val Ile 
    210                 215                 220                 


Ala Ser Gly Asp Thr Tyr Ser Lys Val Arg Gly Ile Asn Phe Asp Lys 
225                 230                 235                 240 


Ser Tyr Pro Ala Gly Glu Tyr Thr Ile Asn Ala Gln Val Val Asp Ile 
                245                 250                 255     


Val Ser Gly Glu Arg Val Glu Gln Ser Met Thr Val Val Lys Lys Met 
            260                 265                 270         


Ile Lys Leu Lys Phe Gly Val Phe Phe Thr Val Leu Leu Ser Ser Ala 
        275                 280                 285             


Tyr Ala His Gly Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr 
    290                 295                 300                 


His Asn Thr Gln Ile Tyr Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr 
305                 310                 315                 320 


Glu Ser Leu Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn 
                325                 330                 335     


Gly Ala Ile Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser 
            340                 345                 350         


Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr 
        355                 360                 365             


Leu Thr Glu Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys Thr 
    370                 375                 380                 


Pro His Ala Ile Ala Ala Ile Ser Met Ala Asn 
385                 390                 395 


<210>  37
<211>  1128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Met Ser Asn Phe Lys Gly Ser Ile Met Asn Lys Arg His Tyr Tyr Leu 
1               5                   10                  15      


Ala Ser Cys Leu Ala Leu Leu Phe Ser Thr Ala Ser Tyr Ala Glu Val 
            20                  25                  30          


Asp Cys Glu Leu Gln Pro Val Ile Glu Ala Asn Leu Ser Leu Asn Gln 
        35                  40                  45              


Asn Gln Leu Ala Ser Asn Gly Gly Tyr Ile Ser Ser Gln Leu Gly Ile 
    50                  55                  60                  


Arg Asn Glu Ser Cys Glu Thr Val Lys Phe Lys Tyr Trp Leu Ser Ile 
65                  70                  75                  80  


Lys Gly Pro Glu Gly Ile Tyr Phe Pro Ala Lys Ala Val Val Gly Val 
                85                  90                  95      


Asp Thr Ala Gln Gln Glu Ser Asp Ala Leu Thr Asp Gly Arg Met Leu 
            100                 105                 110         


Asn Val Thr Arg Gly Phe Trp Val Pro Glu Tyr Met Ala Asp Gly Lys 
        115                 120                 125             


Tyr Thr Val Ser Leu Gln Val Val Ala Glu Asn Gly Lys Val Phe Lys 
    130                 135                 140                 


Ala Asn Gln Glu Phe Val Lys Gly Val Asp Leu Asn Ser Leu Pro Glu 
145                 150                 155                 160 


Leu Asn Gly Leu Thr Ile Asp Ile Lys Asn Gln Phe Gly Ile Asn Ser 
                165                 170                 175     


Val Glu Ser Thr Gly Gly Phe Val Pro Phe Thr Val Asp Leu Asn Asn 
            180                 185                 190         


Gly Arg Glu Gly Glu Ala Asn Val Glu Phe Trp Met Thr Ala Val Gly 
        195                 200                 205             


Pro Asp Gly Leu Ile Ile Pro Val Asn Ala Arg Glu Lys Trp Val Ile 
    210                 215                 220                 


Ala Ser Gly Asp Thr Tyr Ser Lys Val Arg Gly Ile Asn Phe Asp Lys 
225                 230                 235                 240 


Ser Tyr Pro Ala Gly Glu Tyr Thr Ile Asn Ala Gln Val Val Asp Ile 
                245                 250                 255     


Val Ser Gly Glu Arg Val Glu Gln Ser Met Thr Val Val Lys Lys Met 
            260                 265                 270         


Asn Arg Met Thr Leu Cys Ala Ala Ser Ile Ala Cys Ala Leu Ala Ser 
        275                 280                 285             


Thr Ala Met Ala Ala Pro Ser Ala Pro Ser Val Asp Val Tyr Gly Ser 
    290                 295                 300                 


Asn Asn Leu Gln Phe Ser Lys Ile Glu Leu Ala Met Glu Thr Thr Ala 
305                 310                 315                 320 


Gly Tyr Asn Gln Met Val Lys Tyr His Glu Glu Ala Pro Ile Thr Leu 
                325                 330                 335     


Lys Phe Asn Gln Trp Ser Gly Val Thr Gly Asn Thr Tyr Lys Ile Tyr 
            340                 345                 350         


Phe Asp Gly Val Glu Val Ala Thr Gly Pro Ile Ser Gly Ser Gln Thr 
        355                 360                 365             


Thr Ala Gln Phe Thr Tyr Pro Lys Gly Gly Val Tyr Gln Leu Val Ile 
    370                 375                 380                 


Glu Ala Cys Asp Ala Thr Gly Cys Thr Lys Ser Ala Pro Ser Glu Ile 
385                 390                 395                 400 


Thr Ile Ala Asp Thr Asp Gly Ser His Leu Lys Pro Leu Lys Met Asn 
                405                 410                 415     


Val Asp Pro Asn Asn Lys Ser Tyr Thr Ile Pro Gln Asn Thr Val Ile 
            420                 425                 430         


Gly Thr Tyr Phe Val Glu Trp Ser Ile Tyr Asp Arg Lys Phe Thr Val 
        435                 440                 445             


Asp Asn Ile Pro Gly Gln Asn Leu Thr His Ile Leu Tyr Gly Phe Ile 
    450                 455                 460                 


Pro Ile Cys Gly Pro Asn Glu Ser Leu Lys Ser Val Gly Gly Asn Ser 
465                 470                 475                 480 


Phe Asn Ala Leu Gln Thr Ala Cys Lys Gly Val Pro Asp Phe Glu Val 
                485                 490                 495     


Val Ile His Asp Pro Trp Ala Ala Tyr Gln Lys Ser Phe Pro Gln Ala 
            500                 505                 510         


Gly His Gln Tyr Ser Ser Pro Ile Lys Gly Asn Tyr Ala Met Leu Met 
        515                 520                 525             


Ala Leu Lys Lys Thr Tyr Pro Asp Leu Lys Ile Ile Pro Ser Ile Gly 
    530                 535                 540                 


Gly Trp Thr Leu Ser Asp Pro Phe Phe Ser Phe Thr Asp Lys Ala Lys 
545                 550                 555                 560 


Arg Asp Val Phe Val Ala Ser Val Lys Arg Phe Leu Lys Thr Trp Lys 
                565                 570                 575     


Phe Tyr Asp Gly Val Asp Ile Asp Trp Glu Tyr Pro Gly Gly Gly Gly 
            580                 585                 590         


Gln Ala Ala Asp Leu Gly Asp Pro Val Lys Asp Gly Pro Ala Tyr Val 
        595                 600                 605             


Ala Leu Met Ala Glu Leu Arg Ala Met Leu Asp Glu Leu Glu Ala Glu 
    610                 615                 620                 


Thr Gly Arg Lys Tyr Glu Leu Thr Ser Ala Ile Gly Val Gly His Asp 
625                 630                 635                 640 


Lys Ile Glu Asp Val Asn Tyr Gly Gln Ala Val Gln Tyr Met Asp Tyr 
                645                 650                 655     


Ile Phe Ala Met Thr Tyr Asp Phe Tyr Gly Gly Trp Asn Asn Val Leu 
            660                 665                 670         


Gly His Gln Thr Ala Leu Tyr Cys Gly Ser Phe Met Arg Pro Gly Gln 
        675                 680                 685             


Cys Asp Gly Lys Gly Val Asp Glu Asn Gly Glu Pro Tyr Lys Gly Pro 
    690                 695                 700                 


Ala Tyr Thr Thr Asp Asn Gly Ile Gln Leu Leu Leu Ala Gln Gly Val 
705                 710                 715                 720 


Pro Pro Ser Lys Leu Val Val Gly Ala Ala Met Tyr Gly Arg Gly Trp 
                725                 730                 735     


Glu Gly Val Thr Pro Ala Ser Leu Lys Asp Pro Asn Asp Pro Met Thr 
            740                 745                 750         


Gly Val Gly Asn Gly Lys Leu Lys Gly Thr Thr Ala Gln Gly Val Trp 
        755                 760                 765             


Glu Ala Gly Val Ile Asp Tyr Lys Gly Val Lys Asn Phe Met Leu Gly 
    770                 775                 780                 


Ala Asn Lys Thr Gly Val Asn Gly Phe Glu Tyr Gly Tyr Asp Glu Gln 
785                 790                 795                 800 


Ala Glu Ala Pro Trp Val Trp Asn Arg Thr Thr Gly Gln Leu Val Thr 
                805                 810                 815     


Phe Asp Asp Asp Arg Ser Val Lys Ala Lys Gly Ala Tyr Val Arg Asn 
            820                 825                 830         


Leu Gly Leu Ala Gly Leu Phe Ser Trp Glu Ile Asp Ala Asp Asn Gly 
        835                 840                 845             


Asp Ile Leu Asn Ala Met His Glu Gly Leu Ala Gly Gly Thr Thr Thr 
    850                 855                 860                 


Pro Pro Val Asn Lys Ala Pro Val Ala Asn Ala Gly Ala Asp Ile Thr 
865                 870                 875                 880 


Val Thr Gly Pro Ala Ala Val Ser Leu Asp Gly Ser Ala Ser Lys Asp 
                885                 890                 895     


Ser Asp Gly Ser Ile Ala Ser Tyr Leu Trp Glu Gln Thr Ala Gly Pro 
            900                 905                 910         


Ala Val Thr Leu Thr Gly Ala Asn Ser Ala Lys Ala Ser Phe Asn Ala 
        915                 920                 925             


Ala Glu Val Thr Glu Lys Gln Thr Phe Thr Phe Lys Leu Thr Val Thr 
    930                 935                 940                 


Asp Asn Lys Gly Ala Thr Ala Thr Asp Thr Val Val Val Thr Val Asn 
945                 950                 955                 960 


Pro Lys Ser Thr Thr Pro Val Asn Thr Ala Pro Val Ala Ala Leu Ser 
                965                 970                 975     


Ala Pro Ala Ser Val Lys Ala Gly Ala Thr Val Val Val Asp Ala Ser 
            980                 985                 990         


Ala Ser Ser Asp Ala Asp Gln Asp  Pro Leu Ser Phe Thr  Trp Asp Leu 
        995                 1000                 1005             


Pro Val  Gly Val Asn Ala Thr  Val Gln Gly Ala Lys  Val Thr Phe 
    1010                 1015                 1020             


Val Ala  Gly Glu Tyr Thr Gln  Asp Thr Thr Leu Asp  Phe Thr Val 
    1025                 1030                 1035             


Thr Val  Ser Asp Gly Lys Ala  Thr Ser Lys Ala Ser  Ala Ser Val 
    1040                 1045                 1050             


Leu Val  Glu Lys Lys Ala Gly  Thr Gly Gly Asp Ala  Cys Thr Asn 
    1055                 1060                 1065             


Leu Trp  Asn Ala Glu Ser Ile  Tyr Thr Gly Gly Gln  Gln Val Thr 
    1070                 1075                 1080             


Trp Ala  Gly Lys Thr Trp Glu  Ala Lys Trp Trp Thr  Arg Gly Glu 
    1085                 1090                 1095             


Asp Pro  Ser Lys Ser Gly Gln  Trp Gly Val Trp Lys  Asp Leu Gly 
    1100                 1105                 1110             


Ala Ala  Ser Cys Ser Thr His  Asp Tyr Lys Asp Asp  Asp Asp Lys 
    1115                 1120                 1125             


