               SEQUENCE LISTING

<110> GENE SIGNAL INTERNATIONAL SA

<120> USE OF AN INHIBITOR OF IRS-1 FOR TREATING SKIN DISORDERS

<130> CV - 148/PCT

<160> 30

<170> BiSSAP 1.0

<210> 1
<211> 150
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..150
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 1
tagtactcga ggcgcgccgg gcccccagcc tcgctggccg cgcgcagtac gaagaagcgt     60

ttgtgcatgc tcttgggttt gcgcaggtag cccaccttgc gcacgtccga gaagccatcg    120

ctctccggag ggctcgccat gctgccaccg                                     150


<210> 2
<211> 25
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..25
<223> /mol_type="DNA"
      /note="IRS antisense"
      /organism="artificial sequences"

<400> 2
tctccggagg gctcgccatg ctgct                                          25


<210> 3
<211> 25
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..25
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 3
tatccggagg gctcgccatg ctgct                                          25


<210> 4
<211> 24
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..24
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 4
tctccggagg gctcgccatg ctgc                                           24


<210> 5
<211> 23
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..23
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 5
tctccggagg gctcgccatg ctg                                            23


<210> 6
<211> 22
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..22
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 6
tctccggagg gctcgccatg ct                                             22


<210> 7
<211> 21
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 7
tctccggagg gctcgccatg c                                              21


<210> 8
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 8
tctccggagg gctcgccatg                                                20


<210> 9
<211> 19
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..19
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 9
tctccggagg gctcgccat                                                 19


<210> 10
<211> 24
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..24
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 10
ctccggaggg ctcgccatgc tgct                                           24


<210> 11
<211> 23
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..23
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 11
tccggagggc tcgccatgct gct                                            23


<210> 12
<211> 22
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..22
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 12
ccggagggct cgccatgctg ct                                             22


<210> 13
<211> 21
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 13
cggagggctc gccatgctgc t                                              21


<210> 14
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 14
ggagggctcg ccatgctgct                                                20


<210> 15
<211> 19
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..19
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 15
gagggctcgc catgctgct                                                 19


<210> 16
<211> 18
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..18
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 16
agggctcgcc atgctgct                                                  18


<210> 17
<211> 16
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..16
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 17
ggctcgccat gctgct                                                    16


<210> 18
<211> 15
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..15
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 18
gctcgccatg ctgct                                                     15


<210> 19
<211> 14
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..14
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 19
ctcgccatgc tgct                                                      14


<210> 20
<211> 13
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..13
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 20
tcgccatgct gct                                                       13


<210> 21
<211> 12
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..12
<223> /mol_type="DNA"
      /note="IRS1 antisense"
      /organism="artificial sequences"

<400> 21
cgccatgctg ct                                                        12


<210> 22
<211> 25
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..25
<223> /mol_type="DNA"
      /note="scramble oligonucleotide "
      /organism="artificial sequences"

<400> 22
tggacctctg gagctctcga cgtgc                                          25


<210> 23
<211> 21
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /note="Primer sense for IRS1"
      /organism="artificial sequences"

<400> 23
ctcaactgga catcacagca g                                              21


<210> 24
<211> 24
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..24
<223> /mol_type="DNA"
      /note="Primer antisense for IRS1"
      /organism="artificial sequences"

<400> 24
aggtcctagt tgtgaatcat gaaa                                           24


<210> 25
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="Primer sense for VEGF-A"
      /organism="artificial sequences"

<400> 25
gagggcagaa tcatcacgaa                                                20


<210> 26
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="Primer antisense for VEGF-A"
      /organism="artificial sequences"

<400> 26
tgctgtcttg ggtgcattgg                                                20


<210> 27
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="Primer sense for TNF-alpha"
      /organism="artificial sequences"

<400> 27
aatctccgac caccactaca                                                20


<210> 28
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="Primer antisense for TNF-alpha"
      /organism="artificial sequences"

<400> 28
tgatcgtaca ggtgcatcgt                                                20


<210> 29
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="Primer sense for GAPDH"
      /organism="artificial sequences"

<400> 29
tgaaggtcgg agtcaacgga                                                20


<210> 30
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="Primer antisense for GAPDH"
      /organism="artificial sequences"

<400> 30
cattgatgac aagcttcccg                                                20


