﻿               SEQUENCE LISTING

<110> Medizinische Universität Wien

<120> Complement split product C4d for the treatment of inflammatory conditions

<130> U1104 PCT S3

<150> EP12 17 4644.0
<151> 2012-07-02

<160> 13

<170> BiSSAP 1.2

<210> 1
<211> 1140
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1140
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 1
accttggaaa tacctggcaa ctctgatccc aatatgatcc ctgatgggga ctttaacagc      60

tacgtcaggg ttacagcctc agatccattg gacactttag gctctgaggg ggccttgtca     120

ccaggaggcg tggcctccct cttgaggctt cctcgaggct gtggggagca aaccatgatc     180

tacttggctc cgacactggc tgcttcccgc tacctggaca agacagagca gtggagcaca     240

ctgcctcccg agaccaagga ccacgccgtg gatctgatcc agaaaggcta catgcggatc     300

cagcagtttc ggaaggcgga tggttcctat gcggcttggt tgtcacggga cagcagcacc     360

tggctcacag cctttgtgtt gaaggtcctg agtttggccc aggagcaggt aggaggctcg     420

cctgagaaac tgcaggagac atctaactgg cttctgtccc agcagcaggc tgacggctcg     480

ttccaggacc cctgtccagt gttagacagg agcatgcagg ggggtttggt gggcaatgat     540

gagactgtgg cactcacagc ctttgtgacc atcgcccttc atcatgggct ggccgtcttc     600

caggatgagg gtgcagagcc attgaagcag agagtggaag cctccatctc aaaggcaaac     660

tcatttttgg gggagaaagc aagtgctggg ctcctgggtg cccacgcagc tgccatcacg     720

gcctatgccc tgacactgac caaggcgcct gtggacctgc tcggtgttgc ccacaacaac     780

ctcatggcaa tggcccagga gactggagat aacctgtact ggggctcagt cactggttct     840

cagagcaatg ccgtgtcgcc caccccggct cctcgcaacc catccgaccc catgccccag     900

gccccagccc tgtggattga aaccacagcc tacgccctgc tgcacctcct gcttcacgag     960

ggcaaagcag agatggcaga ccaggcttcg gcctggctca cccgtcaggg cagcttccaa    1020

gggggattcc gcagtaccca agacacggtg attgccctgg atgccctgtc tgcctactgg    1080

attgcctccc acaccactga ggagaggggt ctcaatgtga ctctcagctc cacaggccgg    1140


<210> 2
<211> 380
<212> PRT
<213> Homo sapiens


<400> 2
Thr Leu Glu Ile Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly 
1               5                   10                  15      
Asp Phe Asn Ser Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr 
            20                  25                  30          
Leu Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu 
        35                  40                  45              
Arg Leu Pro Arg Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro 
    50                  55                  60                  
Thr Leu Ala Ala Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr 
65                  70                  75                  80  
Leu Pro Pro Glu Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly 
                85                  90                  95      
Tyr Met Arg Ile Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala 
            100                 105                 110         
Trp Leu Ser Arg Asp Ser Ser Thr Trp Leu Thr Ala Phe Val Leu Lys 
        115                 120                 125             
Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly Ser Pro Glu Lys Leu 
    130                 135                 140                 
Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln Gln Ala Asp Gly Ser 
145                 150                 155                 160 
Phe Gln Asp Pro Cys Pro Val Leu Asp Arg Ser Met Gln Gly Gly Leu 
                165                 170                 175     
Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala Phe Val Thr Ile Ala 
            180                 185                 190         
Leu His His Gly Leu Ala Val Phe Gln Asp Glu Gly Ala Glu Pro Leu 
        195                 200                 205             
Lys Gln Arg Val Glu Ala Ser Ile Ser Lys Ala Asn Ser Phe Leu Gly 
    210                 215                 220                 
Glu Lys Ala Ser Ala Gly Leu Leu Gly Ala His Ala Ala Ala Ile Thr 
225                 230                 235                 240 
Ala Tyr Ala Leu Thr Leu Thr Lys Ala Pro Val Asp Leu Leu Gly Val 
                245                 250                 255     
Ala His Asn Asn Leu Met Ala Met Ala Gln Glu Thr Gly Asp Asn Leu 
            260                 265                 270         
Tyr Trp Gly Ser Val Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr 
        275                 280                 285             
Pro Ala Pro Arg Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu 
    290                 295                 300                 
Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu 
305                 310                 315                 320 
Gly Lys Ala Glu Met Ala Asp Gln Ala Ser Ala Trp Leu Thr Arg Gln 
                325                 330                 335     
Gly Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala 
            340                 345                 350         
Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu Glu 
        355                 360                 365             
Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly Arg 
    370                 375                 380 

<210> 3
<211> 1140
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1140
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 3
accttggaaa tacctggcaa ctctgatccc aatatgatcc ctgatgggga ctttaacagc      60

tacgtcaggg ttacagcctc agatccattg gacactttag gctctgaggg ggccttgtca     120

ccaggaggcg tggcctccct cttgaggctt cctcgaggct gtggggagca aaccatgatc     180

tacttggctc cgacactggc tgcttcccgc tacctggaca agacagagca gtggagcaca     240

ctgcctcccg agaccaagga ccacgccgtg gatctgatcc agaaaggcta catgcggatc     300

cagcagtttc ggaaggcgga tggttcctat gcggcttggt tgtcacgggg cagcagcacc     360

tggctcacag cctttgtgtt gaaggtcctg agtttggccc aggagcaggt aggaggctcg     420

cctgagaaac tgcaggagac atctaactgg cttctgtccc agcagcaggc tgacggctcg     480

ttccaggacc tctctccagt gatacatagg agcatgcagg ggggtttggt gggcaatgat     540

gagactgtgg cactcacagc ctttgtgacc atcgcccttc atcatgggct ggccgtcttc     600

caggatgagg gtgcagagcc attgaagcag agagtggaag cctccatctc aaaggcaagc     660

tcatttttgg gggagaaagc aagtgctggg ctcctgggtg cccacgcagc tgccatcacg     720

gcctatgccc tgacactgac caaggcccct gcggacctgc ggggtgttgc ccacaacaac     780

ctcatggcaa tggcccagga gactggagat aacctgtact ggggctcagt cactggttct     840

cagagcaatg ccgtgtcgcc caccccggct cctcgcaacc catccgaccc catgccccag     900

gccccagccc tgtggattga aaccacagcc tacgccctgc tgcacctcct gcttcacgag     960

ggcaaagcag agatggcaga ccaggctgcg gcctggctca cccgtcaggg cagcttccaa    1020

gggggattcc gcagtaccca agacacggtg attgccctgg atgccctgtc tgcctactgg    1080

attgcctccc acaccactga ggagaggggt ctcaatgtga ctctcagctc cacaggccgg    1140


<210> 4
<211> 380
<212> PRT
<213> Homo sapiens


<400> 4
Thr Leu Glu Ile Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly 
1               5                   10                  15      
Asp Phe Asn Ser Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr 
            20                  25                  30          
Leu Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu 
        35                  40                  45              
Arg Leu Pro Arg Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro 
    50                  55                  60                  
Thr Leu Ala Ala Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr 
65                  70                  75                  80  
Leu Pro Pro Glu Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly 
                85                  90                  95      
Tyr Met Arg Ile Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala 
            100                 105                 110         
Trp Leu Ser Arg Gly Ser Ser Thr Trp Leu Thr Ala Phe Val Leu Lys 
        115                 120                 125             
Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly Ser Pro Glu Lys Leu 
    130                 135                 140                 
Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln Gln Ala Asp Gly Ser 
145                 150                 155                 160 
Phe Gln Asp Leu Ser Pro Val Ile His Arg Ser Met Gln Gly Gly Leu 
                165                 170                 175     
Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala Phe Val Thr Ile Ala 
            180                 185                 190         
Leu His His Gly Leu Ala Val Phe Gln Asp Glu Gly Ala Glu Pro Leu 
        195                 200                 205             
Lys Gln Arg Val Glu Ala Ser Ile Ser Lys Ala Ser Ser Phe Leu Gly 
    210                 215                 220                 
Glu Lys Ala Ser Ala Gly Leu Leu Gly Ala His Ala Ala Ala Ile Thr 
225                 230                 235                 240 
Ala Tyr Ala Leu Thr Leu Thr Lys Ala Pro Ala Asp Leu Arg Gly Val 
                245                 250                 255     
Ala His Asn Asn Leu Met Ala Met Ala Gln Glu Thr Gly Asp Asn Leu 
            260                 265                 270         
Tyr Trp Gly Ser Val Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr 
        275                 280                 285             
Pro Ala Pro Arg Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu 
    290                 295                 300                 
Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu 
305                 310                 315                 320 
Gly Lys Ala Glu Met Ala Asp Gln Ala Ala Ala Trp Leu Thr Arg Gln 
                325                 330                 335     
Gly Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala 
            340                 345                 350         
Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu Glu 
        355                 360                 365             
Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly Arg 
    370                 375                 380 

<210> 5
<211> 2292
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2292
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 5
aacgtgaact tccaaaaggc gattaatgag aaattgggtc agtatgcttc cccgacagcc      60

aagcgctgct gccaggatgg ggtgacacgt ctgcccatga tgcgttcctg cgagcagcgg     120

gcagcccgcg tgcagcagcc ggactgccgg gagcccttcc tgtcctgctg ccaatttgct     180

gagagtctgc gcaagaagag cagggacaag ggccaggcgg gcctccaacg agccctggag     240

atcctgcagg aggaggacct gattgatgag gatgacattc ccgtgcgcag cttcttccca     300

gagaactggc tctggagagt ggaaacagtg gaccgctttc aaatattgac actgtggctc     360

cccgactctc tgaccacgtg ggagatccat ggcctgagcc tgtccaaaac caaaggccta     420

tgtgtggcca ccccagtcca gctccgggtg ttccgcgagt tccacctgca cctccgcctg     480

cccatgtctg tccgccgctt tgagcagctg gagctgcggc ctgtcctcta taactacctg     540

gataaaaacc tgactgtgag cgtccacgtg tccccagtgg aggggctgtg cctggctggg     600

ggcggagggc tggcccagca ggtgctggtg cctgcgggct ctgcccggcc tgttgccttc     660

tctgtggtgc ccacggcagc cgccgctgtg tctctgaagg tggtggctcg agggtccttc     720

gaattccctg tgggagatgc ggtgtccaag gttctgcaga ttgagaagga aggggccatc     780

catagagagg agctggtcta tgaactcaac cccttggacc accgaggccg gaccttggaa     840

atacctggca actctgatcc caatatgatc cctgatgggg actttaacag ctacgtcagg     900

gttacagcct cagatccatt ggacacttta ggctctgagg gggccttgtc accaggaggc     960

gtggcctccc tcttgaggct tcctcgaggc tgtggggagc aaaccatgat ctacttggct    1020

ccgacactgg ctgcttcccg ctacctggac aagacagagc agtggagcac actgcctccc    1080

gagaccaagg accacgccgt ggatctgatc cagaaaggct acatgcggat ccagcagttt    1140

cggaaggcgg atggttccta tgcggcttgg ttgtcacggg acagcagcac ctggctcaca    1200

gcctttgtgt tgaaggtcct gagtttggcc caggagcagg taggaggctc gcctgagaaa    1260

ctgcaggaga catctaactg gcttctgtcc cagcagcagg ctgacggctc gttccaggac    1320

ccctgtccag tgttagacag gagcatgcag gggggtttgg tgggcaatga tgagactgtg    1380

gcactcacag cctttgtgac catcgccctt catcatgggc tggccgtctt ccaggatgag    1440

ggtgcagagc cattgaagca gagagtggaa gcctccatct caaaggcaaa ctcatttttg    1500

ggggagaaag caagtgctgg gctcctgggt gcccacgcag ctgccatcac ggcctatgcc    1560

ctgacactga ccaaggcgcc tgtggacctg ctcggtgttg cccacaacaa cctcatggca    1620

atggcccagg agactggaga taacctgtac tggggctcag tcactggttc tcagagcaat    1680

gccgtgtcgc ccaccccggc tcctcgcaac ccatccgacc ccatgcccca ggccccagcc    1740

ctgtggattg aaaccacagc ctacgccctg ctgcacctcc tgcttcacga gggcaaagca    1800

gagatggcag accaggcttc ggcctggctc acccgtcagg gcagcttcca agggggattc    1860

cgcagtaccc aagacacggt gattgccctg gatgccctgt ctgcctactg gattgcctcc    1920

cacaccactg aggagagggg tctcaatgtg actctcagct ccacaggccg gaatgggttc    1980

aagtcccacg cgctgcagct gaacaaccgc cagattcgcg gcctggagga ggagctgcag    2040

ttttccttgg gcagcaagat caatgtgaag gtgggaggaa acagcaaagg aaccctgaag    2100

gtccttcgta cctacaatgt cctggacatg aagaacacga cctgccagga cctacagata    2160

gaagtgacag tcaaaggcca cgtcgagtac acgatggaag caaacgagga ctatgaggac    2220

tatgagtacg atgagcttcc agccaaggat gacccagatg cccctctgca gcccgtgaca    2280

cccctgcagc tg                                                        2292


<210> 6
<211> 764
<212> PRT
<213> Homo sapiens


<400> 6
Asn Val Asn Phe Gln Lys Ala Ile Asn Glu Lys Leu Gly Gln Tyr Ala 
1               5                   10                  15      
Ser Pro Thr Ala Lys Arg Cys Cys Gln Asp Gly Val Thr Arg Leu Pro 
            20                  25                  30          
Met Met Arg Ser Cys Glu Gln Arg Ala Ala Arg Val Gln Gln Pro Asp 
        35                  40                  45              
Cys Arg Glu Pro Phe Leu Ser Cys Cys Gln Phe Ala Glu Ser Leu Arg 
    50                  55                  60                  
Lys Lys Ser Arg Asp Lys Gly Gln Ala Gly Leu Gln Arg Ala Leu Glu 
65                  70                  75                  80  
Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile Pro Val Arg 
                85                  90                  95      
Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Thr Val Asp Arg 
            100                 105                 110         
Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu Thr Thr Trp Glu 
        115                 120                 125             
Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu Cys Val Ala Thr 
    130                 135                 140                 
Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu His Leu Arg Leu 
145                 150                 155                 160 
Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu Arg Pro Val Leu 
                165                 170                 175     
Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val His Val Ser Pro 
            180                 185                 190         
Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu Ala Gln Gln Val 
        195                 200                 205             
Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser Val Val Pro 
    210                 215                 220                 
Thr Ala Ala Ala Ala Val Ser Leu Lys Val Val Ala Arg Gly Ser Phe 
225                 230                 235                 240 
Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu Gln Ile Glu Lys 
                245                 250                 255     
Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu Leu Asn Pro Leu 
            260                 265                 270         
Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn Ser Asp Pro Asn 
        275                 280                 285             
Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val Thr Ala Ser 
    290                 295                 300                 
Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly 
305                 310                 315                 320 
Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu Gln Thr Met 
                325                 330                 335     
Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu Asp Lys Thr 
            340                 345                 350         
Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His Ala Val Asp 
        355                 360                 365             
Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg Lys Ala Asp 
    370                 375                 380                 
Gly Ser Tyr Ala Ala Trp Leu Ser Arg Asp Ser Ser Thr Trp Leu Thr 
385                 390                 395                 400 
Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly 
                405                 410                 415     
Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln 
            420                 425                 430         
Gln Ala Asp Gly Ser Phe Gln Asp Pro Cys Pro Val Leu Asp Arg Ser 
        435                 440                 445             
Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala 
    450                 455                 460                 
Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe Gln Asp Glu 
465                 470                 475                 480 
Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile Ser Lys Ala 
                485                 490                 495     
Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu Gly Ala His 
            500                 505                 510         
Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys Ala Pro Val 
        515                 520                 525             
Asp Leu Leu Gly Val Ala His Asn Asn Leu Met Ala Met Ala Gln Glu 
    530                 535                 540                 
Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser Gln Ser Asn 
545                 550                 555                 560 
Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp Pro Met Pro 
                565                 570                 575     
Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His 
            580                 585                 590         
Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln Ala Ser Ala 
        595                 600                 605             
Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln 
    610                 615                 620                 
Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser 
625                 630                 635                 640 
His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly 
                645                 650                 655     
Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn Arg Gln Ile 
            660                 665                 670         
Arg Gly Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser Lys Ile Asn 
        675                 680                 685             
Val Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val Leu Arg Thr 
    690                 695                 700                 
Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp Leu Gln Ile 
705                 710                 715                 720 
Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu Ala Asn Glu 
                725                 730                 735     
Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys Asp Asp Pro 
            740                 745                 750         
Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu 
        755                 760                 

<210> 7
<211> 2292
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2292
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 7
aacgtgaact tccaaaaggc gattaatgag aaattgggtc agtatgcttc cccgacagcc      60

aagcgctgct gccaggatgg ggtgacacgt ctgcccatga tgcgttcctg cgagcagcgg     120

gcagcccgcg tgcagcagcc ggactgccgg gagcccttcc tgtcctgctg ccaatttgct     180

gagagtctgc gcaagaagag cagggacaag ggccaggcgg gcctccaacg agccctggag     240

atcctgcagg aggaggacct gattgatgag gatgacattc ccgtgcgcag cttcttccca     300

gagaactggc tctggagagt ggaaacagtg gaccgctttc aaatattgac actgtggctc     360

cccgactctc tgaccacgtg ggagatccat ggcctgagcc tgtccaaaac caaaggccta     420

tgtgtggcca ccccagtcca gctccgggtg ttccgcgagt tccacctgca cctccgcctg     480

cccatgtctg tccgccgctt tgagcagctg gagctgcggc ctgtcctcta taactacctg     540

gataaaaacc tgactgtgag cgtccacgtg tccccagtgg aggggctgtg cctggctggg     600

ggcggagggc tggcccagca ggtgctggtg cctgcgggct ctgcccggcc tgttgccttc     660

tctgtggtgc ccacggcagc caccgctgtg tctctgaagg tggtggctcg agggtccttc     720

gaattccctg tgggagatgc ggtgtccaag gttctgcaga ttgagaagga aggggccatc     780

catagagagg agctggtcta tgaactcaac cccttggacc accgaggccg gaccttggaa     840

atacctggca actctgatcc caatatgatc cctgatgggg actttaacag ctacgtcagg     900

gttacagcct cagatccatt ggacacttta ggctctgagg gggccttgtc accaggaggc     960

gtggcctccc tcttgaggct tcctcgaggc tgtggggagc aaaccatgat ctacttggct    1020

ccgacactgg ctgcttcccg ctacctggac aagacagagc agtggagcac actgcctccc    1080

gagaccaagg accacgccgt ggatctgatc cagaaaggct acatgcggat ccagcagttt    1140

cggaaggcgg atggttccta tgcggcttgg ttgtcacggg gcagcagcac ctggctcaca    1200

gcctttgtgt tgaaggtcct gagtttggcc caggagcagg taggaggctc gcctgagaaa    1260

ctgcaggaga catctaactg gcttctgtcc cagcagcagg ctgacggctc gttccaggac    1320

ctctctccag tgatacatag gagcatgcag gggggtttgg tgggcaatga tgagactgtg    1380

gcactcacag cctttgtgac catcgccctt catcatgggc tggccgtctt ccaggatgag    1440

ggtgcagagc cattgaagca gagagtggaa gcctccatct caaaggcaag ctcatttttg    1500

ggggagaaag caagtgctgg gctcctgggt gcccacgcag ctgccatcac ggcctatgcc    1560

ctgacactga ccaaggcccc tgcggacctg cggggtgttg cccacaacaa cctcatggca    1620

atggcccagg agactggaga taacctgtac tggggctcag tcactggttc tcagagcaat    1680

gccgtgtcgc ccaccccggc tcctcgcaac ccatccgacc ccatgcccca ggccccagcc    1740

ctgtggattg aaaccacagc ctacgccctg ctgcacctcc tgcttcacga gggcaaagca    1800

gagatggcag accaggctgc ggcctggctc acccgtcagg gcagcttcca agggggattc    1860

cgcagtaccc aagacacggt gattgccctg gatgccctgt ctgcctactg gattgcctcc    1920

cacaccactg aggagagggg tctcaatgtg actctcagct ccacaggccg gaatgggttc    1980

aagtcccacg cgctgcagct gaacaaccgc cagattcgcg gcctggagga ggagctgcag    2040

ttttccttgg gcagcaagat caatgtgaag gtgggaggaa acagcaaagg aaccctgaag    2100

gtccttcgta cctacaatgt cctggacatg aagaacacga cctgccagga cctacagata    2160

gaagtgacag tcaaaggcca cgtcgagtac acgatggaag caaacgagga ctatgaggac    2220

tatgagtacg atgagcttcc agccaaggat gacccagatg cccctctgca gcccgtgaca    2280

cccctgcagc tg                                                        2292


<210> 8
<211> 764
<212> PRT
<213> Homo sapiens


<400> 8
Asn Val Asn Phe Gln Lys Ala Ile Asn Glu Lys Leu Gly Gln Tyr Ala 
1               5                   10                  15      
Ser Pro Thr Ala Lys Arg Cys Cys Gln Asp Gly Val Thr Arg Leu Pro 
            20                  25                  30          
Met Met Arg Ser Cys Glu Gln Arg Ala Ala Arg Val Gln Gln Pro Asp 
        35                  40                  45              
Cys Arg Glu Pro Phe Leu Ser Cys Cys Gln Phe Ala Glu Ser Leu Arg 
    50                  55                  60                  
Lys Lys Ser Arg Asp Lys Gly Gln Ala Gly Leu Gln Arg Ala Leu Glu 
65                  70                  75                  80  
Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile Pro Val Arg 
                85                  90                  95      
Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Thr Val Asp Arg 
            100                 105                 110         
Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu Thr Thr Trp Glu 
        115                 120                 125             
Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu Cys Val Ala Thr 
    130                 135                 140                 
Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu His Leu Arg Leu 
145                 150                 155                 160 
Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu Arg Pro Val Leu 
                165                 170                 175     
Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val His Val Ser Pro 
            180                 185                 190         
Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu Ala Gln Gln Val 
        195                 200                 205             
Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser Val Val Pro 
    210                 215                 220                 
Thr Ala Ala Thr Ala Val Ser Leu Lys Val Val Ala Arg Gly Ser Phe 
225                 230                 235                 240 
Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu Gln Ile Glu Lys 
                245                 250                 255     
Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu Leu Asn Pro Leu 
            260                 265                 270         
Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn Ser Asp Pro Asn 
        275                 280                 285             
Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val Thr Ala Ser 
    290                 295                 300                 
Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly 
305                 310                 315                 320 
Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu Gln Thr Met 
                325                 330                 335     
Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu Asp Lys Thr 
            340                 345                 350         
Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His Ala Val Asp 
        355                 360                 365             
Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg Lys Ala Asp 
    370                 375                 380                 
Gly Ser Tyr Ala Ala Trp Leu Ser Arg Gly Ser Ser Thr Trp Leu Thr 
385                 390                 395                 400 
Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly 
                405                 410                 415     
Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln 
            420                 425                 430         
Gln Ala Asp Gly Ser Phe Gln Asp Leu Ser Pro Val Ile His Arg Ser 
        435                 440                 445             
Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala 
    450                 455                 460                 
Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe Gln Asp Glu 
465                 470                 475                 480 
Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile Ser Lys Ala 
                485                 490                 495     
Ser Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu Gly Ala His 
            500                 505                 510         
Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys Ala Pro Ala 
        515                 520                 525             
Asp Leu Arg Gly Val Ala His Asn Asn Leu Met Ala Met Ala Gln Glu 
    530                 535                 540                 
Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser Gln Ser Asn 
545                 550                 555                 560 
Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp Pro Met Pro 
                565                 570                 575     
Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His 
            580                 585                 590         
Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln Ala Ala Ala 
        595                 600                 605             
Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln 
    610                 615                 620                 
Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser 
625                 630                 635                 640 
His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly 
                645                 650                 655     
Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn Arg Gln Ile 
            660                 665                 670         
Arg Gly Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser Lys Ile Asn 
        675                 680                 685             
Val Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val Leu Arg Thr 
    690                 695                 700                 
Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp Leu Gln Ile 
705                 710                 715                 720 
Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu Ala Asn Glu 
                725                 730                 735     
Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys Asp Asp Pro 
            740                 745                 750         
Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu 
        755                 760                 

<210> 9
<211> 2913
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2913
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 9
agtgtcaaga aagaagtcaa cttttcttcc cctacttccc tgcatttctc ctctgtgctc      60

actgccacac gcagctcaac ctggacggca cagccagagg cgagatgctt ctctgctgat     120

ctgagtctgc ctgcagcatg gacctgggtc ttccctgaag catctccagg gctggaggga     180

cgactgccat gcaccgaggg ctcatccatc cgcagagcag ggcagtggga ggagacgcca     240

tgacccccat cgtcacagtc ctgatctgtc tcgggctgag tctgggcccc aggacccacg     300

tgcagacagg gaccattccc aagcccaccc tgtgggctga gccagactct gtgatcaccc     360

aggggagtcc cgtcaccctc agttgtcagg ggagccttga agcccaggag taccgtctat     420

atagggagaa aaaatcagca tcttggatta cacggatacg accagagctt gtgaagaacg     480

gccagttcca catcccatcc atcacctggg aacacacagg gcgatatggc tgtcagtatt     540

acagccgcgc tcggtggtct gagctcagtg accccctggt gctggtgatg acaggagcct     600

acccaaaacc caccctctca gcccagccca gccctgtggt gacctcagga ggaagggtga     660

ccctccagtg tgagtcacag gtggcatttg gcggcttcat tctgtgtaag gaaggagaag     720

aagaacaccc acaatgcctg aactcccagc cccatgcccg tgggtcgtcc cgcgccatct     780

tctccgtggg ccccgtgagc ccgaatcgca ggtggtcgca caggtgctat ggttatgact     840

tgaactctcc ctatgtgtgg tcttcaccca gtgatctcct ggagctcctg gtcccaggtg     900

tttctaagaa gccatcactc tcagtgcagc cgggtcctgt cgtggcccct ggggaaagcc     960

tgaccctcca gtgtgtctct gatgtcggct atgacagatt tgttctgtac aaggaggggg    1020

aacgtgacct tcgccagctc cctggccggc agccccaggc tgggctctcc caggccaact    1080

tcaccctggg ccctgtgagc cgctcctacg ggggccagta cagatgctac ggtgcacaca    1140

acctctcctc tgagtgctcg gcccccagcg accccctgga catcctgatc acaggacaga    1200

tccgtggcac acccttcatc tcagtgcagc caggccccac agtggcctca ggagagaacg    1260

tgaccctgct gtgtcagtca tggcggcagt tccacacttt ccttctgacc aaggcgggag    1320

cagctgatgc cccactccgt ctaagatcaa tacacgaata tcctaagtac caggctgaat    1380

tccccatgag tcctgtgacc tcagcccacg cggggaccta caggtgctac ggctcactca    1440

actccgaccc ctacctgctg tctcacccca gtgagcccct ggagctcgtg gtctcaggac    1500

cctccatggg ttccagcccc ccacccaccg gtcccatctc cacacctgca ggccctgagg    1560

accagcccct cacccccact gggtcggatc cccaaagtgg tctgggaagg cacctggggg    1620

ttgtgatcgg catcttggtg gccgtcgtcc tactgctcct cctcctcctc ctcctcttcc    1680

tcatcctccg acatcgacgt cagggcaaac actggacatc gacccagaga aaggctgatt    1740

tccaacatcc tgcaggggct gtggggccag agcccacaga cagaggcctg cagtggaggt    1800

ccagcccagc tgccgacgcc caggaagaaa acctctatgc tgccgtgaag gacacacagc    1860

ctgaagatgg ggtggagatg gacactcggg ctgctgcatc tgaagccccc caggatgtga    1920

cctacgccca gctgcacagc ttgaccctca gacggaaggc aactgagcct cctccatccc    1980

aggaaaggga acctccagct gagcccagca tctacgccac cctggccatc cactagcccg    2040

gagggtacgc agactccaca ctcagtagaa ggagactcag gactgctgaa ggcacgggag    2100

ctgcccccag tggacaccaa tgaaccccag tcagcctgga cccctaacaa agaccatgag    2160

gagatgctgg gaactttggg actcacttga ttctgcagtc gaaataacta atatccctac    2220

attttttaat taaagcaaca gacttctcaa taatcaatga gttaaccgag aaaactaaaa    2280

tcagaagtaa gaatgtgctt taaactgaat cacaatataa atattacaca tcacacaatg    2340

aaattgaaaa agtacaaacc acaaatgaaa aaagtagaaa cgaaaaaaaa aaactaggaa    2400

atgaatgacg ttggctttcg tataaggaat ttagaaaaag aataaccaat tattccaaat    2460

gaaggtgtaa gaaagggaat aagaagaaga agagttgctc atgaggaaaa accaaaactt    2520

gaaaattcaa caaagccaat gaagctcatt cttgaaaata ttaattacag tcataaatcc    2580

taactacatt gagcaagaga aagaaagagc aggcacgcat ttccatatgg gagtgagcca    2640

gcagacagcc cagcagatcc tacacacatt ttcacaaact aaccccagaa caggctgcaa    2700

acctatacca atatactaga aaatgcagat taaatggatg aaatattcaa aactggagtt    2760

tacataatga acgtaagagt aatcagagaa tctgactcat tttaaatgtg tgtgtatgtg    2820

tgtgtatata tatgtgtgtg tgtgtgtgtg tgtgtgtgtg tgaaaaacat tgactgtaat    2880

aaaaatgttc ccatcgtaaa aaaaaaaaaa aaa                                 2913


<210> 10
<211> 598
<212> PRT
<213> Homo sapiens


<400> 10
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      
Pro Arg Thr His Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          
Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              
Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  
Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  
Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      
Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         
Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             
Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 
Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 
Glu Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     
Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         
Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             
Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 
Pro Ser Leu Ser Val Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser 
225                 230                 235                 240 
Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     
Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         
Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             
Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 
Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 
Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     
Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         
Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             
Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 
Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 
Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     
Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         
Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             
Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 
Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 
Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     
Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         
Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             
Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 
Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
545                 550                 555                 560 
Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu 
                565                 570                 575     
Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr 
            580                 585                 590         
Ala Thr Leu Ala Ile His 
        595             

<210> 11
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..12
<223> /mol_type="unassigned DNA"
      /note="Linker"
      /organism="Artificial Sequence"

<400> 11
gggsgggsgg gs                                                        12


<210> 12
<211> 643
<212> PRT
<213> Artificial Sequence

<220> 
<223> C4Ad-Immunoglobulin G1 fusion protein

<400> 12
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      
Met Leu Val Ala Ser Cys Leu Gly Thr Leu Glu Ile Pro Gly Asn Ser 
            20                  25                  30          
Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val 
        35                  40                  45              
Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser 
    50                  55                  60                  
Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu 
65                  70                  75                  80  
Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu 
                85                  90                  95      
Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His 
            100                 105                 110         
Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg 
        115                 120                 125             
Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg Asp Ser Ser Thr 
    130                 135                 140                 
Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln 
145                 150                 155                 160 
Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu 
                165                 170                 175     
Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Pro Cys Pro Val Leu 
            180                 185                 190         
Asp Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala 
        195                 200                 205             
Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe 
    210                 215                 220                 
Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile 
225                 230                 235                 240 
Ser Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu 
                245                 250                 255     
Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys 
            260                 265                 270         
Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn Leu Met Ala Met 
        275                 280                 285             
Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser 
    290                 295                 300                 
Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp 
305                 310                 315                 320 
Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala 
                325                 330                 335     
Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln 
            340                 345                 350         
Ala Ala Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg 
        355                 360                 365             
Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp 
    370                 375                 380                 
Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser 
385                 390                 395                 400 
Ser Thr Gly Arg Gly Gly Gly Asp Pro Glu Gly Asp Pro Lys Ser Cys 
                405                 410                 415     
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            420                 425                 430         
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        435                 440                 445             
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    450                 455                 460                 
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
465                 470                 475                 480 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                485                 490                 495     
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            500                 505                 510         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        515                 520                 525             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    530                 535                 540                 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
545                 550                 555                 560 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                565                 570                 575     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            580                 585                 590         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        595                 600                 605             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    610                 615                 620                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
625                 630                 635                 640 
Pro Gly Lys 
            

<210> 13
<211> 643
<212> PRT
<213> Artificial Sequence

<220> 
<223> C4Bd-Immunoglobulin G1 fusion protein

<400> 13
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      
Met Leu Val Ala Ser Cys Leu Gly Thr Leu Glu Ile Pro Gly Asn Ser 
            20                  25                  30          
Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val 
        35                  40                  45              
Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser 
    50                  55                  60                  
Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu 
65                  70                  75                  80  
Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu 
                85                  90                  95      
Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His 
            100                 105                 110         
Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg 
        115                 120                 125             
Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg Asp Ser Ser Thr 
    130                 135                 140                 
Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln 
145                 150                 155                 160 
Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu 
                165                 170                 175     
Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Leu Ser Pro Val Ile 
            180                 185                 190         
His Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala 
        195                 200                 205             
Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe 
    210                 215                 220                 
Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile 
225                 230                 235                 240 
Ser Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu 
                245                 250                 255     
Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys 
            260                 265                 270         
Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn Leu Met Ala Met 
        275                 280                 285             
Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser 
    290                 295                 300                 
Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp 
305                 310                 315                 320 
Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala 
                325                 330                 335     
Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln 
            340                 345                 350         
Ala Ala Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg 
        355                 360                 365             
Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp 
    370                 375                 380                 
Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser 
385                 390                 395                 400 
Ser Thr Gly Arg Gly Gly Gly Asp Pro Glu Gly Asp Pro Lys Ser Cys 
                405                 410                 415     
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            420                 425                 430         
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        435                 440                 445             
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    450                 455                 460                 
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
465                 470                 475                 480 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                485                 490                 495     
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            500                 505                 510         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        515                 520                 525             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    530                 535                 540                 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
545                 550                 555                 560 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                565                 570                 575     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            580                 585                 590         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        595                 600                 605             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    610                 615                 620                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
625                 630                 635                 640 
Pro Gly Lys 
            

