                         SEQUENCE LISTING

<110>  Howard, Kenneth  A
       Bienk, Konrad
       Kragh-Hansen, Ulrich
 
<120>  Modified payload molecules and their interactions and uses

<130>  49497PC01

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1758
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1758)
<223>  Human serum albumin (mature protein)

<400>  1
gat gca cac aag agt gag gtt gct cat cgg ttt aaa gat ttg gga gaa         48
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu           
1               5                   10                  15                

gaa aat ttc aaa gcc ttg gtg ttg att gcc ttt gct cag tat ctt cag         96
Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln           
            20                  25                  30                    

cag tgt cca ttt gaa gat cat gta aaa tta gtg aat gaa gta act gaa        144
Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu           
        35                  40                  45                        

ttt gca aaa aca tgt gtt gct gat gag tca gct gaa aat tgt gac aaa        192
Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys           
    50                  55                  60                            

tca ctt cat acc ctt ttt gga gac aaa tta tgc aca gtt gca act ctt        240
Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu           
65                  70                  75                  80            

cgt gaa acc tat ggt gaa atg gct gac tgc tgt gca aaa caa gaa cct        288
Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro           
                85                  90                  95                

gag aga aat gaa tgc ttc ttg caa cac aaa gat gac aac cca aac ctc        336
Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu           
            100                 105                 110                   

ccc cga ttg gtg aga cca gag gtt gat gtg atg tgc act gct ttt cat        384
Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His           
        115                 120                 125                       

gac aat gaa gag aca ttt ttg aaa aaa tac tta tat gaa att gcc aga        432
Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg           
    130                 135                 140                           

aga cat cct tac ttt tat gcc ccg gaa ctc ctt ttc ttt gct aaa agg        480
Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg           
145                 150                 155                 160           

tat aaa gct gct ttt aca gaa tgt tgc caa gct gct gat aaa gct gcc        528
Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala           
                165                 170                 175               

tgc ctg ttg cca aag ctc gat gaa ctt cgg gat gaa ggg aag gct tcg        576
Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser           
            180                 185                 190                   

tct gcc aaa cag aga ctc aag tgt gcc agt ctc caa aaa ttt gga gaa        624
Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu           
        195                 200                 205                       

aga gct ttc aaa gca tgg gca gta gct cgc ctg agc cag aga ttt ccc        672
Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro           
    210                 215                 220                           

aaa gct gag ttt gca gaa gtt tcc aag tta gtg aca gat ctt acc aaa        720
Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys           
225                 230                 235                 240           

gtc cac acg gaa tgc tgc cat gga gat ctg ctt gaa tgt gct gat gac        768
Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp           
                245                 250                 255               

agg gcg gac ctt gcc aag tat atc tgt gaa aat caa gat tcg atc tcc        816
Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser           
            260                 265                 270                   

agt aaa ctg aag gaa tgc tgt gaa aaa cct ctg ttg gaa aaa tcc cac        864
Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His           
        275                 280                 285                       

tgc att gcc gaa gtg gaa aat gat gag atg cct gct gac ttg cct tca        912
Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser           
    290                 295                 300                           

tta gct gct gat ttt gtt gaa agt aag gat gtt tgc aaa aac tat gct        960
Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala           
305                 310                 315                 320           

gag gca aag gat gtc ttc ctg ggc atg ttt ttg tat gaa tat gca aga       1008
Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg           
                325                 330                 335               

agg cat cct gat tac tct gtc gtg ctg ctg ctg aga ctt gcc aag aca       1056
Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr           
            340                 345                 350                   

tat gaa acc act cta gag aag tgc tgt gcc gct gca gat cct cat gaa       1104
Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu           
        355                 360                 365                       

tgc tat gcc aaa gtg ttc gat gaa ttt aaa cct ctt gtg gaa gag cct       1152
Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro           
    370                 375                 380                           

cag aat tta atc aaa caa aat tgt gag ctt ttt gag cag ctt gga gag       1200
Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu           
385                 390                 395                 400           

tac aaa ttc cag aat gcg cta tta gtt cgt tac acc aag aaa gta ccc       1248
Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro           
                405                 410                 415               

caa gtg tca act cca act ctt gta gag gtc tca aga aac cta gga aaa       1296
Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys           
            420                 425                 430                   

gtg ggc agc aaa tgt tgt aaa cat cct gaa gca aaa aga atg ccc tgt       1344
Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys           
        435                 440                 445                       

gca gaa gac tat cta tcc gtg gtc ctg aac cag tta tgt gtg ttg cat       1392
Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His           
    450                 455                 460                           

gag aaa acg cca gta agt gac aga gtc acc aaa tgc tgc aca gaa tcc       1440
Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser           
465                 470                 475                 480           

ttg gtg aac agg cga cca tgc ttt tca gct ctg gaa gtc gat gaa aca       1488
Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr           
                485                 490                 495               

tac gtt ccc aaa gag ttt aat gct gaa aca ttc acc ttc cat gca gat       1536
Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp           
            500                 505                 510                   

ata tgc aca ctt tct gag aag gag aga caa atc aag aaa caa act gca       1584
Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala           
        515                 520                 525                       

ctt gtt gag ctc gtg aaa cac aag ccc aag gca aca aaa gag caa ctg       1632
Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu           
    530                 535                 540                           

aaa gct gtt atg gat gat ttc gca gct ttt gta gag aag tgc tgc aag       1680
Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys           
545                 550                 555                 560           

gct gac gat aag gag acc tgc ttt gcc gag gag ggt aaa aaa ctt gtt       1728
Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val           
                565                 570                 575               

gct gca agt caa gct gcc tta ggc tta taa                               1758
Ala Ala Ser Gln Ala Ala Leu Gly Leu                                       
            580                 585                                       


<210>  2
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  3
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  3
acuuguggcc guuuacgucg cu                                                22


