                         SEQUENCE LISTING

<110>  AnaMar AB
 
<120>  Determining pathological cartilage turnover

<130>  P1186PC00

<150>  US 61/690,525
<151>  2012-06-28

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  757
<212>  PRT
<213>  Human

<400>  1

Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 
    130                 135                 140                 


Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 
145                 150                 155                 160 


Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 
                165                 170                 175     


Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 
            180                 185                 190         


Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 
        195                 200                 205             


Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg 
    210                 215                 220                 


Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 
225                 230                 235                 240 


Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala 
                245                 250                 255     


Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 
            260                 265                 270         


Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg 
        275                 280                 285             


Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 
    290                 295                 300                 


Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 
305                 310                 315                 320 


Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 
                325                 330                 335     


Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 
            340                 345                 350         


Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 
        355                 360                 365             


Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 
    370                 375                 380                 


Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 
385                 390                 395                 400 


Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 
                405                 410                 415     


Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 
            420                 425                 430         


Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 
        435                 440                 445             


Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 
    450                 455                 460                 


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 
465                 470                 475                 480 


Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 
                485                 490                 495     


Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 
            500                 505                 510         


Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 
        515                 520                 525             


Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 
    530                 535                 540                 


Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 
545                 550                 555                 560 


Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 
                565                 570                 575     


Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 
            580                 585                 590         


Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 
        595                 600                 605             


Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
    610                 615                 620                 


Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 
625                 630                 635                 640 


Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
                645                 650                 655     


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            660                 665                 670         


Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 
        675                 680                 685             


Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 
    690                 695                 700                 


Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 
705                 710                 715                 720 


Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 
                725                 730                 735     


Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 
            740                 745                 750         


Gln Leu Arg Gln Ala 
        755         


<210>  2
<211>  14
<212>  PRT
<213>  Human

<400>  2

Asn Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser 
1               5                   10                  


<210>  3
<211>  22
<212>  PRT
<213>  Human

<400>  3

Leu His Cys Ala Pro Gly Phe Cys Phe Pro Gly Val Ala Cys Ile Gln 
1               5                   10                  15      


Thr Glu Ser Gly Ala Arg 
            20          


<210>  4
<211>  20
<212>  PRT
<213>  Human

<400>  4

Cys Ala Pro Gly Phe Cys Phe Pro Gly Val Ala Cys Ile Gln Thr Glu 
1               5                   10                  15      


Ser Gly Ala Arg 
            20  


<210>  5
<211>  11
<212>  PRT
<213>  Human

<400>  5

Cys Val Pro Asn Ser Val Cys Ile Asn Thr Arg 
1               5                   10      


<210>  6
<211>  19
<212>  PRT
<213>  Human

<400>  6

Gln Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys 
1               5                   10                  15      


Val Pro Asn 
            


<210>  7
<211>  10
<212>  PRT
<213>  Human

<400>  7

Ser Val Cys Ile Asn Thr Arg Gly Ser Phe 
1               5                   10  


<210>  8
<211>  22
<212>  PRT
<213>  Human

<400>  8

Gln Cys Gly Pro Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly 
1               5                   10                  15      


Cys Gln Arg Arg Ala Gln 
            20          


<210>  9
<211>  15
<212>  PRT
<213>  Human

<400>  9

Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr Asp Phe 
1               5                   10                  15  


<210>  10
<211>  14
<212>  PRT
<213>  Human

<400>  10

Thr Glu Ser Gly Ala Arg Cys Gly Pro Cys Pro Ala Gly Phe 
1               5                   10                  


<210>  11
<211>  12
<212>  PRT
<213>  Human

<400>  11

Asn Gln Gly Arg Glu Ile Val Gln Thr Met Asn Ser 
1               5                   10          


<210>  12
<211>  16
<212>  PRT
<213>  Human

<400>  12

Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr 
1               5                   10                  15      


<210>  13
<211>  19
<212>  PRT
<213>  Human

<400>  13

Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr 
1               5                   10                  15      


Thr Ala Phe 
            


<210>  14
<211>  12
<212>  PRT
<213>  Human

<400>  14

Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys 
1               5                   10          


<210>  15
<211>  8
<212>  PRT
<213>  Human

<400>  15

Trp Phe Leu Gln His Arg Pro Gln 
1               5               


<210>  16
<211>  12
<212>  PRT
<213>  Human

<400>  16

Phe Tyr Glu Gly Pro Glu Leu Val Ala Asp Ser Asn 
1               5                   10          


<210>  17
<211>  13
<212>  PRT
<213>  Human

<400>  17

Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu Arg 
1               5                   10              


<210>  18
<211>  5
<212>  PRT
<213>  Human

<400>  18

Gly Met Gln Gln Ser 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Human

<400>  19

Ser Val Arg Pro Leu 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Human

<400>  20

Arg Pro Leu Leu His 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  Human

<400>  21

Val Ala Cys Ile Gln 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Human

<400>  22

Thr Gly Gln His Asn 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  Human

<400>  23

Asn Cys Val Pro Asn 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Human

<400>  24

Gln Arg Arg Ala Gln 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Human

<400>  25

Thr Leu Thr Asp Phe 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Human

<400>  26

Asn Trp Val Val Leu 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Human

<400>  27

Leu Ala Val Gly Tyr 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Human

<400>  28

Gly Tyr Thr Ala Phe 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Human

<400>  29

Ala Leu Trp His Thr 
1               5   


<210>  30
<211>  5
<212>  PRT
<213>  Human

<400>  30

Gln His Arg Pro Gln 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Human

<400>  31

Val Ala Asp Ser Asn 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Human

<400>  32

Arg Leu Gly Val Phe 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Human

<400>  33

Val Arg Thr Gly Leu 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Human

<400>  34

Leu His Cys Ala Pro 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Human

<400>  35

Cys Ala Pro Gly Phe 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Human

<400>  36

Thr Glu Ser Gly Ala 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Human

<400>  37

Cys Val Pro Asn Ser 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Human

<400>  38

Ser Val Cys Ile Asn 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Human

<400>  39

Arg Phe Cys Pro Asp 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Human

<400>  40

Arg Ala Phe Gln Thr 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Human

<400>  41

Asn Gln Gly Arg Glu 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Human

<400>  42

Thr Ala Phe Asn Gly 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Human

<400>  43

Asn Gly Val Asp Phe 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Human

<400>  44

Gly Asp Thr Glu Ser 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Human

<400>  45

Val Gly Tyr Ile Arg 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Human

<400>  46

Val Val Leu Asp Thr 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Human

<400>  47

Cys Phe Ser Gln Glu 
1               5   


