                         SEQUENCE LISTING

<110>  Arthrogen B.V.
 
<120>  Combination for treating an inflammatory disorder

<130>  P6040380PCT

<150>  US 61/664,818
<151>  2012-06-27

<150>  EP 12173853.8
<151>  2012-06-27

<160>  57    

<170>  PatentIn version 3.3

<210>  1
<211>  510
<212>  PRT
<213>  Artificial

<220>
<223>  CD39 derived from homo sapiens

<400>  1

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val 
            260                 265                 270         


Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys 
        275                 280                 285             


Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg 
    290                 295                 300                 


Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly 
305                 310                 315                 320 


Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser 
                325                 330                 335     


Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro 
            340                 345                 350         


Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys 
        355                 360                 365             


Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu 
    370                 375                 380                 


Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser 
385                 390                 395                 400 


Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly 
                405                 410                 415     


Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp 
            420                 425                 430         


Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala 
        435                 440                 445             


Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala 
    450                 455                 460                 


Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu 
465                 470                 475                 480 


Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu 
                485                 490                 495     


Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
            500                 505                 510 


<210>  2
<211>  1533
<212>  DNA
<213>  Artificial

<220>
<223>  CD39 derived from homo sapiens

<400>  2
atggaggaca ccaaggagag caacgtgaag accttctgca gcaagaacat cctggccatc     60

ctgggcttca gcagcatcat cgccgtgatc gccctgctgg ccgtgggcct gacccagaac    120

aaggccctgc ccgagaacgt gaagtacggc atcgtgctgg acgccggcag cagccacacc    180

agcctgtaca tctacaagtg gcccgccgag aaggagaacg acaccggcgt ggtgcaccag    240

gtggaggagt gcagagtgaa gggccccggc atcagcaagt tcgtgcagaa ggtgaacgag    300

atcggcatct acctgaccga ctgcatggag agagccagag aggtgatccc cagaagccag    360

caccaggaga cccccgtgta cctgggcgcc accgccggca tgagactgct gagaatggag    420

agcgaggagc tggccgacag agtgctggac gtggtggaga gaagcctgag caactacccc    480

ttcgacttcc agggcgccag aatcatcacc ggccaggagg agggcgccta cggctggatc    540

accatcaact acctgctggg caagttcagc cagaagacca gatggttcag catcgtgccc    600

tacgagacca acaaccagga gaccttcggc gccctggacc tgggcggcgc cagcacccag    660

gtgaccttcg tgccccagaa ccagaccatc gagagccccg acaacgccct gcagttcaga    720

ctgtacggca aggactacaa cgtgtacacc cacagcttcc tgtgctacgg caaggaccag    780

gccctgtggc agaagctggc caaggacatc caggtggcca gcaacgagat cctgagagac    840

ccctgcttcc accccggcta caagaaggtg gtgaacgtga gcgacctgta caagaccccc    900

tgcaccaaga gattcgagat gaccctgccc ttccagcagt tcgagatcca gggcatcggc    960

aactaccagc agtgccacca gagcatcctg gagctgttca acaccagcta ctgcccctac   1020

agccagtgcg ccttcaacgg catcttcctg ccccccctgc agggcgactt cggcgccttc   1080

agcgccttct acttcgtgat gaagttcctg aacctgacca gcgagaaggt gagccaggag   1140

aaggtgaccg agatgatgaa gaagttctgc gcccagccct gggaggagat caagaccagc   1200

tacgccggcg tgaaggagaa gtacctgagc gagtactgct tcagcggcac ctacatcctg   1260

agcctgctgc tgcagggcta ccacttcacc gccgacagct gggagcacat ccacttcatc   1320

ggcaagatcc agggcagcga cgccggctgg accctgggct acatgctgaa cctgaccaac   1380

atgatccccg ccgagcagcc cctgagcacc cccctgagcc acagcaccta cgtgttcctg   1440

atggtgctgt tcagcctggt gctgttcacc gtggccatca tcggcctgct gatcttccac   1500

aagcccagct acttctggaa ggacatggtg tga                                1533


<210>  3
<211>  574
<212>  PRT
<213>  Artificial

<220>
<223>  CD73 derived from homo sapiens

<400>  3

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Ala Asp Glu Thr Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
                565                 570                 


<210>  4
<211>  1725
<212>  DNA
<213>  Artificial

<220>
<223>  CD73 derived from homo sapiens

<400>  4
atgtgcccca gagccgccag agcccccgcc accctgctgc tggccctggg cgccgtgctg     60

tggcccgccg ccggcgcctg ggagctgacc atcctgcaca ccaacgacgt gcacagcaga    120

ctggagcaga ccagcgagga cagcagcaag tgcgtgaacg ccagcagatg catgggcggc    180

gtggccagac tgttcaccaa ggtgcagcag atcagaagag ccgagcccaa cgtgctgctg    240

ctggacgccg gcgaccagta ccagggcacc atctggttca ccgtgtacaa gggcgccgag    300

gtggcccact tcatgaacgc cctgagatac gacgccatgg ccctgggcaa ccacgagttc    360

gacaacggcg tggagggcct gatcgagccc ctgctgaagg aggccaagtt ccccatcctg    420

agcgccaaca tcaaggccaa gggccccctg gccagccaga tcagcggcct gtacctgccc    480

tacaaggtgc tgcccgtggg cgacgaggtg gtgggcatcg tgggctacac cagcaaggag    540

acccccttcc tgagcaaccc cggcaccaac ctggtgttcg aggacgagat caccgccctg    600

cagcccgagg tggacaagct gaagaccctg aacgtgaaca agatcatcgc cctgggccac    660

agcggcttcg agatggacaa gctgatcgcc cagaaggtga gaggcgtgga cgtggtggtg    720

ggcggccaca gcaacacctt cctgtacacc ggcaaccccc ccagcaagga ggtgcccgcc    780

ggcaagtacc ccttcatcgt gaccagcgac gacggcagaa aggtgcccgt ggtgcaggcc    840

tacgccttcg gcaagtacct gggctacctg aagatcgagt tcgacgagag aggcaacgtg    900

atcagcagcc acggcaaccc catcctgctg aacagcagca tccccgagga ccccagcatc    960

aaggccgaca tcaacaagtg gagaatcaag ctggacaact acagcaccca ggagctgggc   1020

aagaccatcg tgtacctgga cggcagcagc cagagctgca gattcagaga gtgcaacatg   1080

ggcaacctga tctgcgacgc catgatcaac aacaacctga gacacgccga cgagaccttc   1140

tggaaccacg tgagcatgtg catcctgaac ggcggcggca tcagaagccc catcgacgag   1200

agaaacaacg gcaccatcac ctgggagaac ctggccgccg tgctgccctt cggcggcacc   1260

ttcgacctgg tgcagctgaa gggcagcacc ctgaagaagg ccttcgagca cagcgtgcac   1320

agatacggcc agagcaccgg cgagttcctg caggtgggcg gcatccacgt ggtgtacgac   1380

ctgagcagaa agcccggcga cagagtggtg aagctggacg tgctgtgcac caagtgcaga   1440

gtgcccagct acgaccccct gaagatggac gaggtgtaca aggtgatcct gcccaacttc   1500

ctggccaacg gcggcgacgg cttccagatg atcaaggacg agctgctgag acacgacagc   1560

ggcgaccagg acatcaacgt ggtgagcacc tacatcagca agatgaaggt gatctacccc   1620

gccgtggagg gcagaatcaa gttcagcacc ggcagccact gccacggcag cttcagcctg   1680

atcttcctga gcctgtgggc cgtgatcttc gtgctgtacc agtga                   1725


<210>  5
<211>  513
<212>  PRT
<213>  Artificial

<220>
<223>  CD39 derived from mus musculus

<400>  5

Met Ser Arg Met Glu Asp Ile Lys Asp Ser Lys Val Lys Arg Phe Cys 
1               5                   10                  15      


Ser Lys Asn Ile Leu Ile Ile Leu Gly Phe Thr Ser Ile Leu Ala Val 
            20                  25                  30          


Ile Ala Leu Ile Ala Val Gly Leu Thr Gln Asn Lys Pro Leu Pro Glu 
        35                  40                  45              


Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Asn 
    50                  55                  60                  


Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val 
65                  70                  75                  80  


Val Gln Gln Leu Glu Glu Cys Gln Val Lys Gly Pro Gly Ile Ser Lys 
                85                  90                  95      


Tyr Ala Gln Lys Thr Asp Glu Ile Gly Ala Tyr Leu Ala Glu Cys Met 
            100                 105                 110         


Glu Leu Ser Thr Glu Leu Ile Pro Thr Ser Lys His His Gln Thr Pro 
        115                 120                 125             


Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser 
    130                 135                 140                 


Glu Gln Ser Ala Asp Glu Val Leu Ala Ala Val Ser Thr Ser Leu Lys 
145                 150                 155                 160 


Ser Tyr Pro Phe Asp Phe Gln Gly Ala Lys Ile Ile Thr Gly Gln Glu 
                165                 170                 175     


Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Arg Phe 
            180                 185                 190         


Thr Gln Glu Gln Ser Trp Leu Ser Leu Ile Ser Asp Ser Gln Lys Gln 
        195                 200                 205             


Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr 
    210                 215                 220                 


Phe Val Pro Gln Asn Ser Thr Ile Glu Ser Pro Glu Asn Ser Leu Gln 
225                 230                 235                 240 


Phe Arg Leu Tyr Gly Glu Asp Tyr Thr Val Tyr Thr His Ser Phe Leu 
                245                 250                 255     


Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile 
            260                 265                 270         


Gln Val Ser Ser Gly Gly Val Leu Lys Asp Pro Cys Phe Asn Pro Gly 
        275                 280                 285             


Tyr Glu Lys Val Val Asn Val Ser Glu Leu Tyr Gly Thr Pro Cys Thr 
    290                 295                 300                 


Lys Arg Phe Glu Lys Lys Leu Pro Phe Asp Gln Phe Arg Ile Gln Gly 
305                 310                 315                 320 


Thr Gly Asp Tyr Glu Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn 
                325                 330                 335     


Asn Ser His Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Val Phe Leu 
            340                 345                 350         


Pro Pro Leu His Gly Ser Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val 
        355                 360                 365             


Met Asp Phe Phe Lys Lys Val Ala Lys Asn Ser Val Ile Ser Gln Glu 
    370                 375                 380                 


Lys Met Thr Glu Ile Thr Lys Asn Phe Cys Ser Lys Ser Trp Glu Glu 
385                 390                 395                 400 


Thr Lys Thr Ser Tyr Pro Ser Val Lys Glu Lys Tyr Leu Ser Glu Tyr 
                405                 410                 415     


Cys Phe Ser Gly Ala Tyr Ile Leu Ser Leu Leu Gln Gly Tyr Asn Phe 
            420                 425                 430         


Thr Asp Ser Ser Trp Glu Gln Ile His Phe Met Gly Lys Ile Lys Asp 
        435                 440                 445             


Ser Asn Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met 
    450                 455                 460                 


Ile Pro Ala Glu Gln Pro Leu Ser Pro Pro Leu Pro His Ser Thr Tyr 
465                 470                 475                 480 


Ile Gly Leu Met Val Leu Phe Ser Leu Leu Leu Val Ala Val Ala Ile 
                485                 490                 495     


Thr Gly Leu Phe Ile Tyr Ser Lys Pro Ser Tyr Phe Trp Lys Glu Ala 
            500                 505                 510         


Val 
    


<210>  6
<211>  1542
<212>  DNA
<213>  Artificial

<220>
<223>  CD39 derived from mus musculus, codon optimized

<400>  6
atgagccgca tggaggacat caaagactca aaagtgaaaa gattctgctc aaaaaacatt     60

ctcatcattc tggggtttac atcaattctc gctgtgatcg cactgattgc cgtcggcctc    120

actcagaaca agcccctgcc tgagaacgtg aagtacggaa tcgtcctgga cgctgggagc    180

tcccacacca atctgtacat ctacaagtgg ccagcagaga aagaaaacga tacaggcgtg    240

gtccagcagc tggaggaatg ccaggtgaag ggtcccggca tctccaagta cgcccagaaa    300

acagacgaga ttggagctta tctggcagag tgtatggaac tgagcacaga actcatcccc    360

acttccaagc accatcagac acccgtgtac ctgggtgcaa ctgcaggaat gcgactgctc    420

cgcatggagt cagaacagag cgccgacgag gtgctggcag ctgtcagtac ttcactcaaa    480

tcttatccat tcgattttca gggtgccaag atcattaccg gccaggagga aggagcttac    540

gggtggatca ctattaacta tctgctcggg cggttcaccc aggagcagtc ctggctgtct    600

ctcatcagcg actcccagaa gcaggaaacc ttcggcgctc tggatctcgg cggagcaagc    660

acccagatca catttgtgcc acagaatagc acaattgagt cccccgaaaa ctctctgcag    720

ttccgcctct acggggagga ctacaccgtg tacacccact cctttctgtg ctatggcaag    780

gaccaggccc tgtggcagaa gctcgctaaa gatatccagg tgtctagtgg gggtgtcctg    840

aaagatccct gcttcaatcc tggttacgag aaggtggtca acgtgtctga actgtatgga    900

acaccatgta ctaagaggtt cgagaagaaa ctgcccttcg accagtttcg aatccaggga    960

accggggatt acgagcagtg tcaccagagc attctggaac tcttcaacaa tagccattgc   1020

ccatattccc agtgtgcctt caacggagtg tttctgcccc ctctccacgg ttctttcggc   1080

gcctttagtg ctttctactt tgtgatggac ttctttaaga aagtggctaa gaatagtgtc   1140

atctcacagg agaagatgac cgaaatcaca aagaacttct gctctaagag ttgggaggaa   1200

accaagacaa gctacccctc cgtgaaggag aaatacctgt cagaatattg ttttagcggt   1260

gcctacatcc tgtccctgct ccagggctat aatttcaccg actcaagctg ggagcagatc   1320

cactttatgg gcaagatcaa ggattctaac gccggatgga ccctggggta catgctgaat   1380

ctcacaaaca tgatcccagc tgagcagcca ctgtccccac cactccctca ttctacctat   1440

attggcctga tggtgctctt ctccctgctc ctggtggctg tcgcaatcac aggactgttc   1500

atctactcta agccaagtta tttttggaaa gaggcagtgt ga                      1542


<210>  7
<211>  574
<212>  PRT
<213>  Artificial

<220>
<223>  CD73 derived from mus  musculus

<400>  7

Met Arg Pro Ala Ala Ala Lys Val Pro Lys Trp Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ser Ala Leu Leu Pro Gln Trp Pro Ala Ala Ser Ala Trp Glu Leu Thr 
            20                  25                  30          


Ile Leu His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Asp 
        35                  40                  45              


Asp Ser Thr Lys Cys Leu Asn Ala Ser Leu Cys Val Gly Gly Val Ala 
    50                  55                  60                  


Arg Leu Phe Thr Lys Val Gln Gln Ile Arg Lys Glu Glu Pro Asn Val 
65                  70                  75                  80  


Leu Phe Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr 
                85                  90                  95      


Val Tyr Lys Gly Leu Glu Val Ala His Phe Met Asn Ile Leu Gly Tyr 
            100                 105                 110         


Asp Ala Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly 
        115                 120                 125             


Leu Ile Asp Pro Leu Leu Arg Asn Val Lys Phe Pro Ile Leu Ser Ala 
    130                 135                 140                 


Asn Ile Lys Ala Arg Gly Pro Leu Ala His Gln Ile Ser Gly Leu Phe 
145                 150                 155                 160 


Leu Pro Ser Lys Val Leu Ser Val Gly Gly Glu Val Val Gly Ile Val 
                165                 170                 175     


Gly Tyr Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn 
            180                 185                 190         


Leu Val Phe Glu Asp Glu Ile Ser Ala Leu Gln Pro Glu Val Asp Lys 
        195                 200                 205             


Leu Lys Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly 
    210                 215                 220                 


Phe Glu Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Ile 
225                 230                 235                 240 


Val Val Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro 
                245                 250                 255     


Ser Lys Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ala Asp 
            260                 265                 270         


Asp Gly Arg Gln Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr 
        275                 280                 285             


Leu Gly Tyr Leu Lys Val Glu Phe Asp Asp Lys Gly Asn Val Ile Thr 
    290                 295                 300                 


Ser Tyr Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Ala 
305                 310                 315                 320 


Thr Ile Lys Ala Asp Ile Asn Gln Trp Arg Ile Lys Leu Asp Asn Tyr 
                325                 330                 335     


Ser Thr Gln Glu Leu Gly Arg Thr Ile Val Tyr Leu Asp Gly Ser Thr 
            340                 345                 350         


Gln Thr Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp 
        355                 360                 365             


Ala Met Ile Asn Asn Asn Leu Arg His Pro Asp Glu Met Phe Trp Asn 
    370                 375                 380                 


His Val Ser Met Cys Ile Val Asn Gly Gly Gly Ile Arg Ser Pro Ile 
385                 390                 395                 400 


Asp Glu Lys Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val 
                405                 410                 415     


Leu Pro Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr 
            420                 425                 430         


Leu Lys Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr 
        435                 440                 445             


Gly Glu Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Ile Asn 
    450                 455                 460                 


Arg Lys Pro Trp Asn Arg Val Val Gln Leu Glu Val Leu Cys Thr Lys 
465                 470                 475                 480 


Cys Arg Val Pro Ile Tyr Glu Pro Leu Glu Met Asp Lys Val Tyr Lys 
                485                 490                 495     


Val Thr Leu Pro Ser Tyr Leu Ala Asn Gly Gly Asp Gly Phe Gln Met 
            500                 505                 510         


Ile Lys Asp Glu Leu Leu Lys His Asp Ser Gly Asp Gln Asp Ile Ser 
        515                 520                 525             


Val Val Ser Glu Tyr Ile Ser Lys Met Lys Val Val Tyr Pro Ala Val 
    530                 535                 540                 


Glu Gly Arg Ile Lys Phe Ser Ala Ala Ser His Tyr Gln Gly Ser Phe 
545                 550                 555                 560 


Pro Leu Val Ile Leu Ser Phe Trp Ala Met Ile Leu Ile Leu 
                565                 570                 


<210>  8
<211>  1725
<212>  DNA
<213>  Artificial

<220>
<223>  CD73 derived from mus musculus, codon optimized

<400>  8
atgaggcctg cagccgctaa ggtgccaaaa tggctcctgc tcgcactgtc cgccctgctc     60

cctcagtggc cagcagcctc tgcttgggag ctgactatcc tccacaccaa tgatgtgcat    120

agtagactgg aacagacctc agacgatagc acaaagtgcc tgaacgccag cctgtgcgtg    180

ggaggagtcg caagactgtt caccaaggtg cagcagatcc ggaaagagga acctaatgtc    240

ctgtttctcg acgcaggcga ccagtaccag ggcacaatct ggttcaccgt gtacaaggga    300

ctggaggtcg ctcactttat gaacattctg ggttacgacg ccatggctct cggcaatcat    360

gagttcgaca acggagtgga agggctgatc gatcctctgc tccggaatgt gaaatttcca    420

atcctgtcag ctaacattaa ggcacgaggt cctctggcac accagatcag cggactgttc    480

ctcccaagta aagtgctgtc agtcgggggc gaggtggtcg gtattgtggg ctacacctct    540

aaggaaacac ccttcctgag taatcctggc acaaacctcg tgtttgagga cgaaatctct    600

gccctgcagc ctgaggtgga taagctgaaa actctcaatg tcaacaagat cattgcactg    660

ggacacagcg ggttcgaaat ggacaagctg atcgcccaga aagtgagagg ggtcgatatt    720

gtggtcggcg gacatagtaa tactttcctg tacaccggaa accctccatc aaaggaggtg    780

ccagctggga aatatccctt tatcgtgacc gcagacgatg gccggcaggt cccagtggtc    840

caggcatacg ccttcggcaa gtacctgggc tatctcaaag tggagtttga cgataaggga    900

aacgtcatca caagctatgg gaatcccatc ctgctcaact cctctattcc tgaagacgcc    960

actatcaaag ctgatattaa tcagtggagg atcaagctgg acaactactc cactcaggag   1020

ctgggaagaa ccatcgtgta cctggatggg tctactcaga cctgcaggtt cagagaatgt   1080

aatatgggca acctgatctg cgacgccatg attaacaata acctgcgaca ccccgatgag   1140

atgttttgga atcatgtgag catgtgcatc gtcaacgggg gtggcatcag gtcccccatt   1200

gacgagaaga ataacggaac aattacttgg gaaaacctgg ctgcagtgct ccctttcgga   1260

gggacatttg atctggtcca gctcaagggg tccactctga agaaagcctt cgagcactca   1320

gtgcatcgct acggacagag caccggggaa tttctgcaag tgggtggcat ccacgtggtc   1380

tatgacatta atcgaaaacc ctggaacagg gtggtccagc tggaggtgct ctgcactaag   1440

tgtcgagtcc ctatctacga gccactggaa atggacaagg tgtacaaagt caccctgcct   1500

agctatctcg ccaacggagg ggatggattc cagatgatta aggacgagct gctcaaacat   1560

gattctgggg accaggatat ctccgtggtc tctgagtaca ttagtaagat gaaagtggtc   1620

tatcctgctg tggaaggcag gatcaagttc agtgccgctt cacattacca gggttctttt   1680

ccactcgtga ttctctcttt ttgggctatg attctgattc tctga                   1725


<210>  9
<211>  464
<212>  PRT
<213>  Artificial

<220>
<223>  soluble CD39 derived from mus musculus

<400>  9

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Thr Gln Asn Lys Pro Leu Pro 
            20                  25                  30          


Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr 
        35                  40                  45              


Asn Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly 
    50                  55                  60                  


Val Val Gln Gln Leu Glu Glu Cys Gln Val Lys Gly Pro Gly Ile Ser 
65                  70                  75                  80  


Lys Tyr Ala Gln Lys Thr Asp Glu Ile Gly Ala Tyr Leu Ala Glu Cys 
                85                  90                  95      


Met Glu Leu Ser Thr Glu Leu Ile Pro Thr Ser Lys His His Gln Thr 
            100                 105                 110         


Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu 
        115                 120                 125             


Ser Glu Gln Ser Ala Asp Glu Val Leu Ala Ala Val Ser Thr Ser Leu 
    130                 135                 140                 


Lys Ser Tyr Pro Phe Asp Phe Gln Gly Ala Lys Ile Ile Thr Gly Gln 
145                 150                 155                 160 


Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Arg 
                165                 170                 175     


Phe Thr Gln Glu Gln Ser Trp Leu Ser Leu Ile Ser Asp Ser Gln Lys 
            180                 185                 190         


Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile 
        195                 200                 205             


Thr Phe Val Pro Gln Asn Ser Thr Ile Glu Ser Pro Glu Asn Ser Leu 
    210                 215                 220                 


Gln Phe Arg Leu Tyr Gly Glu Asp Tyr Thr Val Tyr Thr His Ser Phe 
225                 230                 235                 240 


Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp 
                245                 250                 255     


Ile Gln Val Ser Ser Gly Gly Val Leu Lys Asp Pro Cys Phe Asn Pro 
            260                 265                 270         


Gly Tyr Glu Lys Val Val Asn Val Ser Glu Leu Tyr Gly Thr Pro Cys 
        275                 280                 285             


Thr Lys Arg Phe Glu Lys Lys Leu Pro Phe Asp Gln Phe Arg Ile Gln 
    290                 295                 300                 


Gly Thr Gly Asp Tyr Glu Gln Cys His Gln Ser Ile Leu Glu Leu Phe 
305                 310                 315                 320 


Asn Asn Ser His Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Val Phe 
                325                 330                 335     


Leu Pro Pro Leu His Gly Ser Phe Gly Ala Phe Ser Ala Phe Tyr Phe 
            340                 345                 350         


Val Met Asp Phe Phe Lys Lys Val Ala Lys Asn Ser Val Ile Ser Gln 
        355                 360                 365             


Glu Lys Met Thr Glu Ile Thr Lys Asn Phe Cys Ser Lys Ser Trp Glu 
    370                 375                 380                 


Glu Thr Lys Thr Ser Tyr Pro Ser Val Lys Glu Lys Tyr Leu Ser Glu 
385                 390                 395                 400 


Tyr Cys Phe Ser Gly Ala Tyr Ile Leu Ser Leu Leu Gln Gly Tyr Asn 
                405                 410                 415     


Phe Thr Asp Ser Ser Trp Glu Gln Ile His Phe Met Gly Lys Ile Lys 
            420                 425                 430         


Asp Ser Asn Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn 
        435                 440                 445             


Met Ile Pro Ala Glu Gln Pro Leu Ser Pro Pro Leu Pro His Ser Thr 
    450                 455                 460                 


<210>  10
<211>  1395
<212>  DNA
<213>  Artificial

<220>
<223>  soluble CD39 derived from mus musculus, codon optimized

<400>  10
atgccttcct ccgtctcatg gggtatcctc ctgctcgctg ggctgtgctg cctggtgcct     60

gtctcactcg ccgaaactca gaacaagcca ctgcccgaga acgtgaagta cggcatcgtc    120

ctggacgcag gaagctccca cacaaacctc tacatctaca agtggcccgc cgagaaagaa    180

aatgatactg gagtggtcca gcagctggag gaatgccagg tgaagggccc tggaatctcc    240

aagtacgccc agaaaaccga cgagattggg gcttatctgg cagagtgtat ggaactgtca    300

acagaactca tccccacttc taaacaccat cagacccccg tgtacctggg agcaacagca    360

ggaatgaggc tgctcagaat ggagtctgaa cagagtgctg acgaggtgct ggccgctgtc    420

tccacctctc tcaagagcta tcccttcgat tttcaggggg ccaaaatcat taccggtcag    480

gaggaaggcg cttacggatg gatcactatt aactatctgc tcgggcgatt cacccaggag    540

cagtcatggc tgagcctcat cagtgactca cagaagcagg aaactttcgg cgcactggat    600

ctcggaggag caagcactca gatcaccttt gtgccacaga acagcaccat tgagtccccc    660

gaaaattctc tgcagttcag actctacggc gaggactaca cagtctatac tcattccttt    720

ctgtgctatg gaaaggacca ggctctgtgg cagaagctcg caaaagatat tcaggtgtct    780

agtgggggtg tcctgaagga tccttgcttc aacccagggt acgagaaagt ggtcaacgtg    840

agcgaactgt atggtacccc ttgtacaaag cggtttgaga agaaactgcc attcgaccag    900

tttcgcatcc aggggacagg cgactacgag cagtgtcacc agagcattct ggaactcttc    960

aacaatagtc attgcccata ttcacagtgt gctttcaacg gcgtgtttct gccacctctc   1020

cacgggagct tcggtgcctt ttccgctttc tacttcgtca tggatttctt taagaaagtg   1080

gcaaagaact ccgtcatctc tcaggagaag atgactgaaa tcaccaagaa cttctgcagc   1140

aaatcctggg aggaaaccaa gacaagttat ccctcagtga aggagaaata cctgtctgaa   1200

tattgtttta gtggcgccta catcctgagt ctgctccagg gatataattt cacagactca   1260

agctgggagc agatccactt catgggcaag atcaaggatt ctaacgctgg gtggactctg   1320

ggttacatgc tcaatctcac caatatgatt ccagccgaac agccactcag ccccccactc   1380

ccacactcaa cctga                                                    1395


<210>  11
<211>  464
<212>  PRT
<213>  Artificial

<220>
<223>  soluble CD39 derived from homo sapiens

<400>  11

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Thr Gln Asn Lys Ala Leu Pro 
            20                  25                  30          


Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr 
        35                  40                  45              


Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly 
    50                  55                  60                  


Val Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser 
65                  70                  75                  80  


Lys Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys 
                85                  90                  95      


Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr 
            100                 105                 110         


Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu 
        115                 120                 125             


Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu 
    130                 135                 140                 


Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln 
145                 150                 155                 160 


Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys 
                165                 170                 175     


Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn 
            180                 185                 190         


Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln 
        195                 200                 205             


Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala 
    210                 215                 220                 


Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser 
225                 230                 235                 240 


Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys 
                245                 250                 255     


Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His 
            260                 265                 270         


Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro 
        275                 280                 285             


Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile 
    290                 295                 300                 


Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu 
305                 310                 315                 320 


Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile 
                325                 330                 335     


Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr 
            340                 345                 350         


Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu 
        355                 360                 365             


Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu 
    370                 375                 380                 


Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr 
385                 390                 395                 400 


Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His 
                405                 410                 415     


Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln 
            420                 425                 430         


Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn 
        435                 440                 445             


Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr 
    450                 455                 460                 


<210>  12
<211>  1395
<212>  DNA
<213>  Artificial

<220>
<223>  soluble CD39 derived from homo sapiens, codon optimized

<400>  12
atgcccagca gcgtgagctg gggcatcctg ctgctggccg gcctgtgctg cctggtgccc     60

gtgagcctgg ccgagaccca gaacaaggcc ctgcccgaga acgtgaagta cggcatcgtg    120

ctggacgccg gcagcagcca caccagcctg tacatctaca agtggcccgc cgagaaggag    180

aacgacaccg gcgtggtgca ccaggtggag gagtgcagag tgaagggccc cggcatcagc    240

aagttcgtgc agaaggtgaa cgagatcggc atctacctga ccgactgcat ggagagagcc    300

agagaggtga tccccagaag ccagcaccag gagacccccg tgtacctggg cgccaccgcc    360

ggcatgagac tgctgagaat ggagagcgag gagctggccg acagagtgct ggacgtggtg    420

gagagaagcc tgagcaacta ccccttcgac ttccagggcg ccagaatcat caccggccag    480

gaggagggcg cctacggctg gatcaccatc aactacctgc tgggcaagtt cagccagaag    540

accagatggt tcagcatcgt gccctacgag accaacaacc aggagacctt cggcgccctg    600

gacctgggcg gcgccagcac ccaggtgacc ttcgtgcccc agaaccagac catcgagagc    660

cccgacaacg ccctgcagtt cagactgtac ggcaaggact acaacgtgta cacccacagc    720

ttcctgtgct acggcaagga ccaggccctg tggcagaagc tggccaagga catccaggtg    780

gccagcaacg agatcctgag agacccctgc ttccaccccg gctacaagaa ggtggtgaac    840

gtgagcgacc tgtacaagac cccctgcacc aagagattcg agatgaccct gcccttccag    900

cagttcgaga tccagggcat cggcaactac cagcagtgcc accagagcat cctggagctg    960

ttcaacacca gctactgccc ctacagccag tgcgccttca acggcatctt cctgcccccc   1020

ctgcagggcg acttcggcgc cttcagcgcc ttctacttcg tgatgaagtt cctgaacctg   1080

accagcgaga aggtgagcca ggagaaggtg accgagatga tgaagaagtt ctgcgcccag   1140

ccctgggagg agatcaagac cagctacgcc ggcgtgaagg agaagtacct gagcgagtac   1200

tgcttcagcg gcacctacat cctgagcctg ctgctgcagg gctaccactt caccgccgac   1260

agctgggagc acatccactt catcggcaag atccagggca gcgacgccgg ctggaccctg   1320

ggctacatgc tgaacctgac caacatgatc cccgccgagc agcccctgag cacccccctg   1380

agccacagca cctga                                                    1395


<210>  13
<211>  550
<212>  PRT
<213>  Artificial

<220>
<223>  soluble CD73 derived from mus musculus

<400>  13

Met Arg Pro Ala Ala Ala Lys Val Pro Lys Trp Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ser Ala Leu Leu Pro Gln Trp Pro Ala Ala Ser Ala Trp Glu Leu Thr 
            20                  25                  30          


Ile Leu His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Asp 
        35                  40                  45              


Asp Ser Thr Lys Cys Leu Asn Ala Ser Leu Cys Val Gly Gly Val Ala 
    50                  55                  60                  


Arg Leu Phe Thr Lys Val Gln Gln Ile Arg Lys Glu Glu Pro Asn Val 
65                  70                  75                  80  


Leu Phe Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr 
                85                  90                  95      


Val Tyr Lys Gly Leu Glu Val Ala His Phe Met Asn Ile Leu Gly Tyr 
            100                 105                 110         


Asp Ala Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly 
        115                 120                 125             


Leu Ile Asp Pro Leu Leu Arg Asn Val Lys Phe Pro Ile Leu Ser Ala 
    130                 135                 140                 


Asn Ile Lys Ala Arg Gly Pro Leu Ala His Gln Ile Ser Gly Leu Phe 
145                 150                 155                 160 


Leu Pro Ser Lys Val Leu Ser Val Gly Gly Glu Val Val Gly Ile Val 
                165                 170                 175     


Gly Tyr Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn 
            180                 185                 190         


Leu Val Phe Glu Asp Glu Ile Ser Ala Leu Gln Pro Glu Val Asp Lys 
        195                 200                 205             


Leu Lys Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly 
    210                 215                 220                 


Phe Glu Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Ile 
225                 230                 235                 240 


Val Val Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro 
                245                 250                 255     


Ser Lys Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ala Asp 
            260                 265                 270         


Asp Gly Arg Gln Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr 
        275                 280                 285             


Leu Gly Tyr Leu Lys Val Glu Phe Asp Asp Lys Gly Asn Val Ile Thr 
    290                 295                 300                 


Ser Tyr Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Ala 
305                 310                 315                 320 


Thr Ile Lys Ala Asp Ile Asn Gln Trp Arg Ile Lys Leu Asp Asn Tyr 
                325                 330                 335     


Ser Thr Gln Glu Leu Gly Arg Thr Ile Val Tyr Leu Asp Gly Ser Thr 
            340                 345                 350         


Gln Thr Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp 
        355                 360                 365             


Ala Met Ile Asn Asn Asn Leu Arg His Pro Asp Glu Met Phe Trp Asn 
    370                 375                 380                 


His Val Ser Met Cys Ile Val Asn Gly Gly Gly Ile Arg Ser Pro Ile 
385                 390                 395                 400 


Asp Glu Lys Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val 
                405                 410                 415     


Leu Pro Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr 
            420                 425                 430         


Leu Lys Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr 
        435                 440                 445             


Gly Glu Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Ile Asn 
    450                 455                 460                 


Arg Lys Pro Trp Asn Arg Val Val Gln Leu Glu Val Leu Cys Thr Lys 
465                 470                 475                 480 


Cys Arg Val Pro Ile Tyr Glu Pro Leu Glu Met Asp Lys Val Tyr Lys 
                485                 490                 495     


Val Thr Leu Pro Ser Tyr Leu Ala Asn Gly Gly Asp Gly Phe Gln Met 
            500                 505                 510         


Ile Lys Asp Glu Leu Leu Lys His Asp Ser Gly Asp Gln Asp Ile Ser 
        515                 520                 525             


Val Val Ser Glu Tyr Ile Ser Lys Met Lys Val Val Tyr Pro Ala Val 
    530                 535                 540                 


Glu Gly Arg Ile Lys Phe 
545                 550 


<210>  14
<211>  1653
<212>  DNA
<213>  Artificial

<220>
<223>  soluble CD73 derived from mus musculus, codon optimized

<400>  14
atgaggcctg cagccgctaa ggtgccaaaa tggctcctgc tcgcactgtc cgccctgctc     60

cctcagtggc cagcagcctc tgcttgggag ctgactatcc tccacaccaa tgatgtgcat    120

agtagactgg aacagacctc agacgatagc acaaagtgcc tgaacgccag cctgtgcgtg    180

ggaggagtcg caagactgtt caccaaggtg cagcagatcc ggaaagagga acctaatgtc    240

ctgtttctcg acgcaggcga ccagtaccag ggcacaatct ggttcaccgt gtacaaggga    300

ctggaggtcg ctcactttat gaacattctg ggttacgacg ccatggctct cggcaatcat    360

gagttcgaca acggagtgga agggctgatc gatcctctgc tccggaatgt gaaatttcca    420

atcctgtcag ctaacattaa ggcacgaggt cctctggcac accagatcag cggactgttc    480

ctcccaagta aagtgctgtc agtcgggggc gaggtggtcg gtattgtggg ctacacctct    540

aaggaaacac ccttcctgag taatcctggc acaaacctcg tgtttgagga cgaaatctct    600

gccctgcagc ctgaggtgga taagctgaaa actctcaatg tcaacaagat cattgcactg    660

ggacacagcg ggttcgaaat ggacaagctg atcgcccaga aagtgagagg ggtcgatatt    720

gtggtcggcg gacatagtaa tactttcctg tacaccggaa accctccatc aaaggaggtg    780

ccagctggga aatatccctt tatcgtgacc gcagacgatg gccggcaggt cccagtggtc    840

caggcatacg ccttcggcaa gtacctgggc tatctcaaag tggagtttga cgataaggga    900

aacgtcatca caagctatgg gaatcccatc ctgctcaact cctctattcc tgaagacgcc    960

actatcaaag ctgatattaa tcagtggagg atcaagctgg acaactactc cactcaggag   1020

ctgggaagaa ccatcgtgta cctggatggg tctactcaga cctgcaggtt cagagaatgt   1080

aatatgggca acctgatctg cgacgccatg attaacaata acctgcgaca ccccgatgag   1140

atgttttgga atcatgtgag catgtgcatc gtcaacgggg gtggcatcag gtcccccatt   1200

gacgagaaga ataacggaac aattacttgg gaaaacctgg ctgcagtgct ccctttcgga   1260

gggacatttg atctggtcca gctcaagggg tccactctga agaaagcctt cgagcactca   1320

gtgcatcgct acggacagag caccggggaa tttctgcaag tgggtggcat ccacgtggtc   1380

tatgacatta atcgaaaacc ctggaacagg gtggtccagc tggaggtgct ctgcactaag   1440

tgtcgagtcc ctatctacga gccactggaa atggacaagg tgtacaaagt caccctgcct   1500

agctatctcg ccaacggagg ggatggattc cagatgatta aggacgagct gctcaaacat   1560

gattctgggg accaggatat ctccgtggtc tctgagtaca ttagtaagat gaaagtggtc   1620

tatcctgctg tggaaggcag gatcaagttc tga                                1653


<210>  15
<211>  548
<212>  PRT
<213>  Artificial

<220>
<223>  soluble CD73 derived from homo sapiens

<400>  15

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Ala Asp Glu Thr Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe 
545             


<210>  16
<211>  1647
<212>  DNA
<213>  Artificial

<220>
<223>  soluble CD73 derived from homo sapiens, codon optimized

<400>  16
atgtgcccca gagccgccag agcccccgcc accctgctgc tggccctggg cgccgtgctg     60

tggcccgccg ccggcgcctg ggagctgacc atcctgcaca ccaacgacgt gcacagcaga    120

ctggagcaga ccagcgagga cagcagcaag tgcgtgaacg ccagcagatg catgggcggc    180

gtggccagac tgttcaccaa ggtgcagcag atcagaagag ccgagcccaa cgtgctgctg    240

ctggacgccg gcgaccagta ccagggcacc atctggttca ccgtgtacaa gggcgccgag    300

gtggcccact tcatgaacgc cctgagatac gacgccatgg ccctgggcaa ccacgagttc    360

gacaacggcg tggagggcct gatcgagccc ctgctgaagg aggccaagtt ccccatcctg    420

agcgccaaca tcaaggccaa gggccccctg gccagccaga tcagcggcct gtacctgccc    480

tacaaggtgc tgcccgtggg cgacgaggtg gtgggcatcg tgggctacac cagcaaggag    540

acccccttcc tgagcaaccc cggcaccaac ctggtgttcg aggacgagat caccgccctg    600

cagcccgagg tggacaagct gaagaccctg aacgtgaaca agatcatcgc cctgggccac    660

agcggcttcg agatggacaa gctgatcgcc cagaaggtga gaggcgtgga cgtggtggtg    720

ggcggccaca gcaacacctt cctgtacacc ggcaaccccc ccagcaagga ggtgcccgcc    780

ggcaagtacc ccttcatcgt gaccagcgac gacggcagaa aggtgcccgt ggtgcaggcc    840

tacgccttcg gcaagtacct gggctacctg aagatcgagt tcgacgagag aggcaacgtg    900

atcagcagcc acggcaaccc catcctgctg aacagcagca tccccgagga ccccagcatc    960

aaggccgaca tcaacaagtg gagaatcaag ctggacaact acagcaccca ggagctgggc   1020

aagaccatcg tgtacctgga cggcagcagc cagagctgca gattcagaga gtgcaacatg   1080

ggcaacctga tctgcgacgc catgatcaac aacaacctga gacacgccga cgagaccttc   1140

tggaaccacg tgagcatgtg catcctgaac ggcggcggca tcagaagccc catcgacgag   1200

agaaacaacg gcaccatcac ctgggagaac ctggccgccg tgctgccctt cggcggcacc   1260

ttcgacctgg tgcagctgaa gggcagcacc ctgaagaagg ccttcgagca cagcgtgcac   1320

agatacggcc agagcaccgg cgagttcctg caggtgggcg gcatccacgt ggtgtacgac   1380

ctgagcagaa agcccggcga cagagtggtg aagctggacg tgctgtgcac caagtgcaga   1440

gtgcccagct acgaccccct gaagatggac gaggtgtaca aggtgatcct gcccaacttc   1500

ctggccaacg gcggcgacgg cttccagatg atcaaggacg agctgctgag acacgacagc   1560

ggcgaccagg acatcaacgt ggtgagcacc tacatcagca agatgaaggt gatctacccc   1620

gccgtggagg gcagaatcaa gttctga                                       1647


<210>  17
<211>  1009
<212>  PRT
<213>  Artificial

<220>
<223>  soluble CD73-CD39 fusion derived from mus musculus

<400>  17

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Trp Glu Leu Thr Ile Leu His 
            20                  25                  30          


Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Asp Asp Ser Thr 
        35                  40                  45              


Lys Cys Leu Asn Ala Ser Leu Cys Val Gly Gly Val Ala Arg Leu Phe 
    50                  55                  60                  


Thr Lys Val Gln Gln Ile Arg Lys Glu Glu Pro Asn Val Leu Phe Leu 
65                  70                  75                  80  


Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr Lys 
                85                  90                  95      


Gly Leu Glu Val Ala His Phe Met Asn Ile Leu Gly Tyr Asp Ala Met 
            100                 105                 110         


Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile Asp 
        115                 120                 125             


Pro Leu Leu Arg Asn Val Lys Phe Pro Ile Leu Ser Ala Asn Ile Lys 
    130                 135                 140                 


Ala Arg Gly Pro Leu Ala His Gln Ile Ser Gly Leu Phe Leu Pro Ser 
145                 150                 155                 160 


Lys Val Leu Ser Val Gly Gly Glu Val Val Gly Ile Val Gly Tyr Thr 
                165                 170                 175     


Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val Phe 
            180                 185                 190         


Glu Asp Glu Ile Ser Ala Leu Gln Pro Glu Val Asp Lys Leu Lys Thr 
        195                 200                 205             


Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu Met 
    210                 215                 220                 


Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Ile Val Val Gly 
225                 230                 235                 240 


Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys Glu 
                245                 250                 255     


Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ala Asp Asp Gly Arg 
            260                 265                 270         


Gln Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly Tyr 
        275                 280                 285             


Leu Lys Val Glu Phe Asp Asp Lys Gly Asn Val Ile Thr Ser Tyr Gly 
    290                 295                 300                 


Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Ala Thr Ile Lys 
305                 310                 315                 320 


Ala Asp Ile Asn Gln Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr Gln 
                325                 330                 335     


Glu Leu Gly Arg Thr Ile Val Tyr Leu Asp Gly Ser Thr Gln Thr Cys 
            340                 345                 350         


Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met Ile 
        355                 360                 365             


Asn Asn Asn Leu Arg His Pro Asp Glu Met Phe Trp Asn His Val Ser 
    370                 375                 380                 


Met Cys Ile Val Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu Lys 
385                 390                 395                 400 


Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro Phe 
                405                 410                 415     


Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys Lys 
            420                 425                 430         


Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu Phe 
        435                 440                 445             


Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Ile Asn Arg Lys Pro 
    450                 455                 460                 


Trp Asn Arg Val Val Gln Leu Glu Val Leu Cys Thr Lys Cys Arg Val 
465                 470                 475                 480 


Pro Ile Tyr Glu Pro Leu Glu Met Asp Lys Val Tyr Lys Val Thr Leu 
                485                 490                 495     


Pro Ser Tyr Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys Asp 
            500                 505                 510         


Glu Leu Leu Lys His Asp Ser Gly Asp Gln Asp Ile Ser Val Val Ser 
        515                 520                 525             


Glu Tyr Ile Ser Lys Met Lys Val Val Tyr Pro Ala Val Glu Gly Arg 
    530                 535                 540                 


Ile Lys Phe Ala Ser Gly Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly 
545                 550                 555                 560 


Ala Gly Gly Gly Ala Gly Gly Gly Thr Gly Thr Gln Asn Lys Pro Leu 
                565                 570                 575     


Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His 
            580                 585                 590         


Thr Asn Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr 
        595                 600                 605             


Gly Val Val Gln Gln Leu Glu Glu Cys Gln Val Lys Gly Pro Gly Ile 
    610                 615                 620                 


Ser Lys Tyr Ala Gln Lys Thr Asp Glu Ile Gly Ala Tyr Leu Ala Glu 
625                 630                 635                 640 


Cys Met Glu Leu Ser Thr Glu Leu Ile Pro Thr Ser Lys His His Gln 
                645                 650                 655     


Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met 
            660                 665                 670         


Glu Ser Glu Gln Ser Ala Asp Glu Val Leu Ala Ala Val Ser Thr Ser 
        675                 680                 685             


Leu Lys Ser Tyr Pro Phe Asp Phe Gln Gly Ala Lys Ile Ile Thr Gly 
    690                 695                 700                 


Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly 
705                 710                 715                 720 


Arg Phe Thr Gln Glu Gln Ser Trp Leu Ser Leu Ile Ser Asp Ser Gln 
                725                 730                 735     


Lys Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln 
            740                 745                 750         


Ile Thr Phe Val Pro Gln Asn Ser Thr Ile Glu Ser Pro Glu Asn Ser 
        755                 760                 765             


Leu Gln Phe Arg Leu Tyr Gly Glu Asp Tyr Thr Val Tyr Thr His Ser 
    770                 775                 780                 


Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys 
785                 790                 795                 800 


Asp Ile Gln Val Ser Ser Gly Gly Val Leu Lys Asp Pro Cys Phe Asn 
                805                 810                 815     


Pro Gly Tyr Glu Lys Val Val Asn Val Ser Glu Leu Tyr Gly Thr Pro 
            820                 825                 830         


Cys Thr Lys Arg Phe Glu Lys Lys Leu Pro Phe Asp Gln Phe Arg Ile 
        835                 840                 845             


Gln Gly Thr Gly Asp Tyr Glu Gln Cys His Gln Ser Ile Leu Glu Leu 
    850                 855                 860                 


Phe Asn Asn Ser His Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Val 
865                 870                 875                 880 


Phe Leu Pro Pro Leu His Gly Ser Phe Gly Ala Phe Ser Ala Phe Tyr 
                885                 890                 895     


Phe Val Met Asp Phe Phe Lys Lys Val Ala Lys Asn Ser Val Ile Ser 
            900                 905                 910         


Gln Glu Lys Met Thr Glu Ile Thr Lys Asn Phe Cys Ser Lys Ser Trp 
        915                 920                 925             


Glu Glu Thr Lys Thr Ser Tyr Pro Ser Val Lys Glu Lys Tyr Leu Ser 
    930                 935                 940                 


Glu Tyr Cys Phe Ser Gly Ala Tyr Ile Leu Ser Leu Leu Gln Gly Tyr 
945                 950                 955                 960 


Asn Phe Thr Asp Ser Ser Trp Glu Gln Ile His Phe Met Gly Lys Ile 
                965                 970                 975     


Lys Asp Ser Asn Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr 
            980                 985                 990         


Asn Met Ile Pro Ala Glu Gln Pro  Leu Ser Pro Pro Leu  Pro His Ser 
        995                 1000                 1005             


Thr 
    


<210>  18
<211>  3030
<212>  DNA
<213>  Artificial

<220>
<223>  soluble CD73-CD39 fusion derived from mus musculus, codon 
       optimized

<400>  18
atgcctagta gcgtgagttg ggggattctg ctgctggctg gtctctgctg cctggtgccc     60

gtgagtctcg ccgagtggga actgacaatc ctgcacacca atgacgtgca tagtcggctc    120

gagcagacat cagacgatag cactaagtgc ctgaacgcca gcctgtgcgt gggaggagtc    180

gcaagactgt tcacaaaggt gcagcagatc cggaaagagg aacctaatgt cctgtttctc    240

gacgctggcg atcagtacca gggaacaatc tggttcaccg tgtacaaggg cctggaggtc    300

gcacacttta tgaacattct ggggtacgac gctatggcac tcggtaatca tgagttcgac    360

aacggggtgg aaggtctgat cgatcctctg ctccggaatg tgaaatttcc aatcctgtca    420

gcaaacatta aggcacgagg accactggca caccagatca gcggtctgtt cctcccctcc    480

aaagtgctgt ctgtcggggg cgaggtggtc ggcattgtgg gatacacctc taaggaaaca    540

cccttcctga gtaatcctgg cactaacctc gtgtttgagg acgaaatcag tgctctgcag    600

cccgaggtgg ataagctgaa aaccctcaat gtcaacaaga tcattgctct ggggcactct    660

ggtttcgaaa tggacaagct gatcgcacag aaagtgagag gcgtcgatat tgtggtcggc    720

ggacatagta atactttcct gtacaccggc aacccccctt caaaggaggt gccagccgga    780

aaatatccct ttatcgtgac cgctgacgat ggacggcagg tccctgtggt ccaggcctac    840

gctttcggca agtacctggg atatctcaaa gtggagtttg acgataaggg caacgtcatt    900

acatcctatg gaaatcccat cctgctcaac agctccattc ctgaagacgc tactatcaaa    960

gcagatatta atcagtggag gatcaagctg gacaactact ccactcagga gctggggaga   1020

accatcgtgt acctggatgg ctctacccag acatgcaggt tcagagaatg taatatgggc   1080

aacctgatct gcgacgccat gattaacaat aacctgcgac acccagatga gatgttttgg   1140

aatcatgtga gcatgtgcat cgtcaacggg ggtggcatca ggtcccctat tgacgagaag   1200

aataacggaa ctattacctg ggaaaacctg gccgctgtgc tcccattcgg agggacattt   1260

gatctggtgc agctcaaggg gagcactctg aagaaagcct tcgagcactc agtgcatcgc   1320

tacgggcaga gcacaggtga atttctgcaa gtgggtggca tccacgtggt ctatgacatt   1380

aatcgaaaac catggaacag ggtggtccag ctggaggtgc tctgcaccaa gtgtcgagtc   1440

ccaatctacg agcccctgga aatggacaag gtgtacaaag tcacactgcc cagctatctc   1500

gccaacggag gggatggatt ccagatgatt aaggacgagc tgctcaaaca tgattctggg   1560

gaccaggata tctccgtggt ctctgagtac attagtaaga tgaaagtggt ctatccagct   1620

gtggaaggca ggatcaagtt cgctagcggt ggaggagcag gaggtggagc tggagggggt   1680

gcaggcggag gggccggtgg cggaaccggt actcagaaca agcctctgcc agagaacgtg   1740

aagtacggga tcgtcctgga cgccggttct agtcacacca atctctacat ctacaagtgg   1800

cccgctgaga aagaaaacga tacaggcgtg gtccagcagc tggaggaatg ccaggtgaag   1860

gggcctggta tctctaagta cgcccagaaa accgacgaga ttggagctta tctggcagag   1920

tgtatggaac tgtccaccga actcatccca acatctaagc accatcagac acccgtgtac   1980

ctgggagcaa ctgcaggaat gcgactgctc cgcatggaga gtgaacagtc agctgacgag   2040

gtgctggcag ccgtcagtac ttcactcaaa agctatccct tcgattttca gggcgcaaag   2100

atcattaccg gacaggagga aggcgcctac ggatggatca ctattaacta tctgctcggg   2160

aggttcaccc aggagcagag ctggctgtcc ctcatcagcg actcccagaa gcaggaaaca   2220

ttcggcgctc tggatctcgg gggtgcatct actcagatca cctttgtgcc tcagaatagt   2280

actattgagt caccagaaaa cagcctgcag ttcagactct acggcgagga ctacacagtg   2340

tatactcaca gctttctgtg ctatggaaag gaccaggccc tgtggcagaa gctcgctaaa   2400

gatatccagg tgtcaagcgg cggagtcctg aaagatcctt gcttcaatcc agggtacgag   2460

aaggtggtca acgtgtccga actgtatggc accccctgta caaagaggtt cgagaagaaa   2520

ctgcctttcg accagtttcg aatccagggc accggagatt acgagcagtg tcaccagtct   2580

attctggaac tcttcaataa ctcccattgc ccctattctc agtgtgcctt caacggcgtg   2640

tttctgccac ccctccacgg gagtttcggt gccttttcag ctttctactt tgtgatggac   2700

ttctttaaga aagtggctaa gaattctgtc atcagtcagg agaagatgac tgaaattacc   2760

aagaacttct gctctaaaag ttgggaggaa accaagacat catatcctag cgtgaaggag   2820

aaatacctga gcgaatattg tttttccgga gcctacatcc tgtccctgct ccaggggtat   2880

aatttcacag actcctcttg ggagcagatc cacttcatgg gcaagatcaa ggatagcaac   2940

gcagggtgga ccctgggtta catgctgaat ctcacaaaca tgatcccagc cgaacagccc   3000

ctgtcccctc cactgcctca ctccacctaa                                    3030


<210>  19
<211>  1009
<212>  PRT
<213>  Artificial

<220>
<223>  soluble CD73-CD39 fusion derived from homo sapiens

<400>  19

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Trp Glu Leu Thr Ile Leu His 
            20                  25                  30          


Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser Ser 
        35                  40                  45              


Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu Phe 
    50                  55                  60                  


Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu Leu 
65                  70                  75                  80  


Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr Lys 
                85                  90                  95      


Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala Met 
            100                 105                 110         


Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile Glu 
        115                 120                 125             


Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile Lys 
    130                 135                 140                 


Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro Tyr 
145                 150                 155                 160 


Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr Thr 
                165                 170                 175     


Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val Phe 
            180                 185                 190         


Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys Thr 
        195                 200                 205             


Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu Met 
    210                 215                 220                 


Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val Gly 
225                 230                 235                 240 


Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys Glu 
                245                 250                 255     


Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly Arg 
            260                 265                 270         


Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly Tyr 
        275                 280                 285             


Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His Gly 
    290                 295                 300                 


Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile Lys 
305                 310                 315                 320 


Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr Gln 
                325                 330                 335     


Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser Cys 
            340                 345                 350         


Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met Ile 
        355                 360                 365             


Asn Asn Asn Leu Arg His Ala Asp Glu Thr Phe Trp Asn His Val Ser 
    370                 375                 380                 


Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu Arg 
385                 390                 395                 400 


Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro Phe 
                405                 410                 415     


Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys Lys 
            420                 425                 430         


Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu Phe 
        435                 440                 445             


Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys Pro 
    450                 455                 460                 


Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg Val 
465                 470                 475                 480 


Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile Leu 
                485                 490                 495     


Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys Asp 
            500                 505                 510         


Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val Ser 
        515                 520                 525             


Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly Arg 
    530                 535                 540                 


Ile Lys Phe Ala Ser Gly Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly 
545                 550                 555                 560 


Ala Gly Gly Gly Ala Gly Gly Gly Thr Gly Thr Gln Asn Lys Ala Leu 
                565                 570                 575     


Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His 
            580                 585                 590         


Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr 
        595                 600                 605             


Gly Val Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile 
    610                 615                 620                 


Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp 
625                 630                 635                 640 


Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu 
                645                 650                 655     


Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met 
            660                 665                 670         


Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser 
        675                 680                 685             


Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly 
    690                 695                 700                 


Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly 
705                 710                 715                 720 


Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr 
                725                 730                 735     


Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr 
            740                 745                 750         


Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn 
        755                 760                 765             


Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His 
    770                 775                 780                 


Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala 
785                 790                 795                 800 


Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe 
                805                 810                 815     


His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr 
            820                 825                 830         


Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu 
        835                 840                 845             


Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu 
    850                 855                 860                 


Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly 
865                 870                 875                 880 


Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe 
                885                 890                 895     


Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln 
            900                 905                 910         


Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu 
        915                 920                 925             


Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu 
    930                 935                 940                 


Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr 
945                 950                 955                 960 


His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile 
                965                 970                 975     


Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr 
            980                 985                 990         


Asn Met Ile Pro Ala Glu Gln Pro  Leu Ser Thr Pro Leu  Ser His Ser 
        995                 1000                 1005             


Thr 
    


<210>  20
<211>  3030
<212>  DNA
<213>  Artificial

<220>
<223>  soluble CD73-CD39 fusion derived from homo sapiens, codon 
       optimized

<400>  20
atgcccagca gcgtgagctg gggcatcctg ctgctggccg gcctgtgctg cctggtgccc     60

gtgagcctgg ccgagtggga gctgaccatc ctgcacacca acgacgtgca cagcagactg    120

gagcagacca gcgaggacag cagcaagtgc gtgaacgcca gcagatgcat gggcggcgtg    180

gccagactgt tcaccaaggt gcagcagatc agaagagccg agcccaacgt gctgctgctg    240

gacgccggcg accagtacca gggcaccatc tggttcaccg tgtacaaggg cgccgaggtg    300

gcccacttca tgaacgccct gagatacgac gccatggccc tgggcaacca cgagttcgac    360

aacggcgtgg agggcctgat cgagcccctg ctgaaggagg ccaagttccc catcctgagc    420

gccaacatca aggccaaggg ccccctggcc agccagatca gcggcctgta cctgccctac    480

aaggtgctgc ccgtgggcga cgaggtggtg ggcatcgtgg gctacaccag caaggagacc    540

cccttcctga gcaaccccgg caccaacctg gtgttcgagg acgagatcac cgccctgcag    600

cccgaggtgg acaagctgaa gaccctgaac gtgaacaaga tcatcgccct gggccacagc    660

ggcttcgaga tggacaagct gatcgcccag aaggtgagag gcgtggacgt ggtggtgggc    720

ggccacagca acaccttcct gtacaccggc aaccccccca gcaaggaggt gcccgccggc    780

aagtacccct tcatcgtgac cagcgacgac ggcagaaagg tgcccgtggt gcaggcctac    840

gccttcggca agtacctggg ctacctgaag atcgagttcg acgagagagg caacgtgatc    900

agcagccacg gcaaccccat cctgctgaac agcagcatcc ccgaggaccc cagcatcaag    960

gccgacatca acaagtggag aatcaagctg gacaactaca gcacccagga gctgggcaag   1020

accatcgtgt acctggacgg cagcagccag agctgcagat tcagagagtg caacatgggc   1080

aacctgatct gcgacgccat gatcaacaac aacctgagac acgccgacga gaccttctgg   1140

aaccacgtga gcatgtgcat cctgaacggc ggcggcatca gaagccccat cgacgagaga   1200

aacaacggca ccatcacctg ggagaacctg gccgccgtgc tgcccttcgg cggcaccttc   1260

gacctggtgc agctgaaggg cagcaccctg aagaaggcct tcgagcacag cgtgcacaga   1320

tacggccaga gcaccggcga gttcctgcag gtgggcggca tccacgtggt gtacgacctg   1380

agcagaaagc ccggcgacag agtggtgaag ctggacgtgc tgtgcaccaa gtgcagagtg   1440

cccagctacg accccctgaa gatggacgag gtgtacaagg tgatcctgcc caacttcctg   1500

gccaacggcg gcgacggctt ccagatgatc aaggacgagc tgctgagaca cgacagcggc   1560

gaccaggaca tcaacgtggt gagcacctac atcagcaaga tgaaggtgat ctaccccgcc   1620

gtggagggca gaatcaagtt cgccagcggc ggcggcgccg gcggcggcgc cggcggcggc   1680

gccggcggcg gcgccggcgg cggcaccggc acccagaaca aggccctgcc cgagaacgtg   1740

aagtacggca tcgtgctgga cgccggcagc agccacacca gcctgtacat ctacaagtgg   1800

cccgccgaga aggagaacga caccggcgtg gtgcaccagg tggaggagtg cagagtgaag   1860

ggccccggca tcagcaagtt cgtgcagaag gtgaacgaga tcggcatcta cctgaccgac   1920

tgcatggaga gagccagaga ggtgatcccc agaagccagc accaggagac ccccgtgtac   1980

ctgggcgcca ccgccggcat gagactgctg agaatggaga gcgaggagct ggccgacaga   2040

gtgctggacg tggtggagag aagcctgagc aactacccct tcgacttcca gggcgccaga   2100

atcatcaccg gccaggagga gggcgcctac ggctggatca ccatcaacta cctgctgggc   2160

aagttcagcc agaagaccag atggttcagc atcgtgccct acgagaccaa caaccaggag   2220

accttcggcg ccctggacct gggcggcgcc agcacccagg tgaccttcgt gccccagaac   2280

cagaccatcg agagccccga caacgccctg cagttcagac tgtacggcaa ggactacaac   2340

gtgtacaccc acagcttcct gtgctacggc aaggaccagg ccctgtggca gaagctggcc   2400

aaggacatcc aggtggccag caacgagatc ctgagagacc cctgcttcca ccccggctac   2460

aagaaggtgg tgaacgtgag cgacctgtac aagaccccct gcaccaagag attcgagatg   2520

accctgccct tccagcagtt cgagatccag ggcatcggca actaccagca gtgccaccag   2580

agcatcctgg agctgttcaa caccagctac tgcccctaca gccagtgcgc cttcaacggc   2640

atcttcctgc cccccctgca gggcgacttc ggcgccttca gcgccttcta cttcgtgatg   2700

aagttcctga acctgaccag cgagaaggtg agccaggaga aggtgaccga gatgatgaag   2760

aagttctgcg cccagccctg ggaggagatc aagaccagct acgccggcgt gaaggagaag   2820

tacctgagcg agtactgctt cagcggcacc tacatcctga gcctgctgct gcagggctac   2880

cacttcaccg ccgacagctg ggagcacatc cacttcatcg gcaagatcca gggcagcgac   2940

gccggctgga ccctgggcta catgctgaac ctgaccaaca tgatccccgc cgagcagccc   3000

ctgagcaccc ccctgagcca cagcacctga                                    3030


<210>  21
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  21

Ala Ser Gly Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Ala Gly Gly 
1               5                   10                  15      


Gly Ala Gly Gly Gly 
            20      


<210>  22
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  hAAT signal sequence

<400>  22

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210>  23
<211>  166
<212>  DNA
<213>  Artificial

<220>
<223>  promoter

<400>  23
ctagcaggcc tcgaggggac tttccacaag gggactttcc gtcgagggga ctttccacaa     60

ggggactttc cgtcgagggg actttccaca aggggacttt ccgtcgaggc ctgtaggcgt    120

gtacggtggg aggcttatat aagcagagct caagcttggt accgag                   166


<210>  24
<211>  130
<212>  DNA
<213>  Artificial

<220>
<223>  single stranded AAV2 ITR, 5' ITR

<400>  24
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt     60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact    120

aggggttcct                                                           130


<210>  25
<211>  142
<212>  DNA
<213>  Artificial

<220>
<223>  single stranded AAV2 ITR, 3'ITR

<400>  25
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc    120

gagcgcgcag ctgcctgcag gg                                             142


<210>  26
<211>  95
<212>  DNA
<213>  Artificial

<220>
<223>  double stranded AAV2 ITR, 5'ITR

<400>  26
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc     60

ctcagtgagc gagcgagcgc gcagagaggg agtgg                                95


<210>  27
<211>  142
<212>  DNA
<213>  Artificial

<220>
<223>  double stranded AAV2 ITR, 3' ITR

<400>  27
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc    120

gagcgcgcag ctgcctgcag gg                                             142


<210>  28
<211>  167
<212>  DNA
<213>  Artificial

<220>
<223>  AAV5 ITR: 5'ITR

<400>  28
ctctcccccc tgtcgcgttc gctcgctcgc tggctcgttt gggggggtgg cagctcaaag     60

agctgccaga cgacggccct ctggccgtcg cccccccaaa cgagccagcg agcgagcgaa    120

cgcgacaggg gggagagtgc cacactctca agcaaggggg ttttgta                  167


<210>  29
<211>  167
<212>  DNA
<213>  Artificial

<220>
<223>  AAV5 ITR: 3'ITR

<400>  29
tacaaaacct ccttgcttga gagtgtggca ctctcccccc tgtcgcgttc gctcgctcgc     60

tggctcgttt gggggggtgg cagctcaaag agctgccaga cgacggccct ctggccgtcg    120

cccccccaaa cgagccagcg agcgagcgaa cgcgacaggg gggagag                  167


<210>  30
<211>  2208
<212>  DNA
<213>  Artificial

<220>
<223>  AAV2 Capsid

<400>  30
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga     60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac    120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac    180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac    240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt    300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag    360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg    420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga    480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac    540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact    600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga    660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc    720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt    780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg    840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc    900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc    960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt   1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga   1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg   1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct   1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc   1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag   1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt   1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga   1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac   1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc   1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc   1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca   1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct   1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt   1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag   1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa   1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc   1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg   2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac   2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat   2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                2208


<210>  31
<211>  735
<212>  PRT
<213>  Artificial

<220>
<223>  AAV2 VP1

<400>  31

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  32
<211>  598
<212>  PRT
<213>  Artificial

<220>
<223>  AAV2 VP2

<400>  32

Thr Ala Pro Gly Lys Lys Arg Pro Val Glu His Ser Pro Val Glu Pro 
1               5                   10                  15      


Asp Ser Ser Ser Gly Thr Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys 
            20                  25                  30          


Arg Leu Asn Phe Gly Gln Thr Gly Asp Ala Asp Ser Val Pro Asp Pro 
        35                  40                  45              


Gln Pro Leu Gly Gln Pro Pro Ala Ala Pro Ser Gly Leu Gly Thr Asn 
    50                  55                  60                  


Thr Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly 
65                  70                  75                  80  


Ala Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr 
                85                  90                  95      


Trp Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
            100                 105                 110         


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly 
        115                 120                 125             


Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
    130                 135                 140                 


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
145                 150                 155                 160 


Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe 
                165                 170                 175     


Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr 
            180                 185                 190         


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
        195                 200                 205             


Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys 
    210                 215                 220                 


Leu Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
225                 230                 235                 240 


Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr 
                245                 250                 255     


Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe 
            260                 265                 270         


Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala 
        275                 280                 285             


His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 
    290                 295                 300                 


Leu Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln 
305                 310                 315                 320 


Ser Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln 
                325                 330                 335     


Ser Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
            340                 345                 350         


Lys Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala 
        355                 360                 365             


Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro 
    370                 375                 380                 


Ala Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser 
385                 390                 395                 400 


Gly Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp 
                405                 410                 415     


Ile Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn 
            420                 425                 430         


Pro Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg 
        435                 440                 445             


Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
465                 470                 475                 480 


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys 
        515                 520                 525             


Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
    530                 535                 540                 


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr 
                565                 570                 575     


Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr Arg Asn Leu 
        595             


<210>  33
<211>  533
<212>  PRT
<213>  Artificial

<220>
<223>  AAV2 VP3

<400>  33

Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala 
    50                  55                  60                  


Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  


Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      


Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys 
            100                 105                 110         


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr 
        115                 120                 125             


Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser 
    130                 135                 140                 


Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu 
145                 150                 155                 160 


Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu 
                165                 170                 175     


Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys 
            180                 185                 190         


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr 
        195                 200                 205             


Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
    210                 215                 220                 


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
225                 230                 235                 240 


Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser 
                245                 250                 255     


Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser 
            260                 265                 270         


Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 
        275                 280                 285             


Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr 
    290                 295                 300                 


Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala 
305                 310                 315                 320 


Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile 
            340                 345                 350         


Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro 
        355                 360                 365             


Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly 
    370                 375                 380                 


Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro 
385                 390                 395                 400 


Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
                405                 410                 415     


Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met 
            420                 425                 430         


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
        435                 440                 445             


Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe 
    450                 455                 460                 


Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile 
465                 470                 475                 480 


Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
                485                 490                 495     


Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val 
            500                 505                 510         


Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
        515                 520                 525             


Leu Thr Arg Asn Leu 
    530             


<210>  34
<211>  2190
<212>  DNA
<213>  Artificial

<220>
<223>  AAV5 capsid

<400>  34
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag     60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa    120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga    180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag    240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag    300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc    360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac gtttaaacgc    420

gatcgcgccc ctaccggaaa gcggatagac gaccactttc caaaaagaaa gaaggctcgg    480

accgaagagg actccaagcc ttccacctcg tcagacgccg aagctggacc cagcggatcc    540

cagcagctgc aaatcccagc ccaaccagcc tcaagtttgg gagctgatac aatgtctgcg    600

ggaggtggcg gcccattggg cgacaataac caaggtgccg atggagtggg caatgcctcg    660

ggagattggc attgcgattc cacgtggatg ggggacagag tcgtcaccaa gtccacccga    720

acctgggtgc tgcccagcta caacaaccac cagtaccgag agatcaaaag cggctccgtc    780

gacggaagca acgccaacgc ctactttgga tacagcaccc cctgggggta ctttgacttt    840

aaccgcttcc acagccactg gagcccccga gactggcaaa gactcatcaa caactactgg    900

ggcttcagac cccggtccct cagagtcaaa atcttcaaca ttcaagtcaa agaggtcacg    960

gtgcaggact ccaccaccac catcgccaac aacctcacct ccaccgtcca agtgtttacg   1020

gacgacgact accagctgcc ctacgtcgtc ggcaacggga ccgagggatg cctgccggcc   1080

ttccctccgc aggtctttac gctgccgcag tacggttacg cgacgctgaa ccgcgacaac   1140

acagaaaatc ccaccgagag gagcagcttc ttctgcctag agtactttcc cagcaagatg   1200

ctgagaacgg gcaacaactt tgagtttacc tacaactttg aggaggtgcc cttccactcc   1260

agcttcgctc ccagtcagaa cctcttcaag ctggccaacc cgctggtgga ccagtacttg   1320

taccgcttcg tgagcacaaa taacactggc ggagtccagt tcaacaagaa cctggccggg   1380

agatacgcca acacctacaa aaactggttc ccggggccca tgggccgaac ccagggctgg   1440

aacctgggct ccggggtcaa ccgcgccagt gtcagcgcct tcgccacgac caataggatg   1500

gagctcgagg gcgcgagtta ccaggtgccc ccgcagccga acggcatgac caacaacctc   1560

cagggcagca acacctatgc cctggagaac actatgatct tcaacagcca gccggcgaac   1620

ccgggcacca ccgccacgta cctcgagggc aacatgctca tcaccagcga gagcgagacg   1680

cagccggtga accgcgtggc gtacaacgtc ggcgggcaga tggccaccaa caaccagagc   1740

tccaccactg cccccgcgac cggcacgtac aacctccagg aaatcgtgcc cggcagcgtg   1800

tggatggaga gggacgtgta cctccaagga cccatctggg ccaagatccc agagacgggg   1860

gcgcactttc acccctctcc ggccatgggc ggattcggac tcaaacaccc accgcccatg   1920

atgctcatca agaacacgcc tgtgcccgga aatatcacca gcttctcgga cgtgcccgtc   1980

agcagcttca tcacccagta cagcaccggg caggtcaccg tggagatgga gtgggagctc   2040

aagaaggaaa actccaagag gtggaaccca gagatccagt acacaaacaa ctacaacgac   2100

ccccagtttg tggactttgc cccggacagc accggggaat acagaaccac cagacctatc   2160

ggaacccgat accttacccg acccctttaa                                    2190


<210>  35
<211>  729
<212>  PRT
<213>  Artificial

<220>
<223>  AAV5 VP1

<400>  35

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Phe Lys Arg Asp Arg Ala Pro 
    130                 135                 140                 


Thr Gly Lys Arg Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg 
145                 150                 155                 160 


Thr Glu Glu Asp Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly 
                165                 170                 175     


Pro Ser Gly Ser Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser 
            180                 185                 190         


Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp 
        195                 200                 205             


Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys 
                245                 250                 255     


Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His Trp Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Ser Leu Arg Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Val Gln Asp Ser Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val 
                325                 330                 335     


Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn 
            340                 345                 350         


Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro 
    370                 375                 380                 


Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val 
                405                 410                 415     


Pro Phe His Ser Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala 
            420                 425                 430         


Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn 
        435                 440                 445             


Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn 
    450                 455                 460                 


Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp 
465                 470                 475                 480 


Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr 
                485                 490                 495     


Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln 
            500                 505                 510         


Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu 
        515                 520                 525             


Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr 
    530                 535                 540                 


Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr 
545                 550                 555                 560 


Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr 
                565                 570                 575     


Asn Asn Gln Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu 
            580                 585                 590         


Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu 
        595                 600                 605             


Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His 
    610                 615                 620                 


Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met 
625                 630                 635                 640 


Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser 
                645                 650                 655     


Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val 
    690                 695                 700                 


Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 


<210>  36
<211>  593
<212>  PRT
<213>  Artificial

<220>
<223>  AAV5 VP2

<400>  36

Thr Phe Lys Arg Asp Arg Ala Pro Thr Gly Lys Arg Ile Asp Asp His 
1               5                   10                  15      


Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser Lys Pro Ser 
            20                  25                  30          


Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln Gln Leu Gln 
        35                  40                  45              


Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr Met Ser Ala 
    50                  55                  60                  


Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala Asp Gly Val 
65                  70                  75                  80  


Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Met Gly Asp 
                85                  90                  95      


Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn 
            100                 105                 110         


Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp Gly Ser Asn 
        115                 120                 125             


Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe 
    130                 135                 140                 


Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile 
145                 150                 155                 160 


Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val Lys Ile Phe 
                165                 170                 175     


Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr Thr Thr Ile 
            180                 185                 190         


Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Asp Asp Tyr 
        195                 200                 205             


Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala 
    210                 215                 220                 


Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu 
225                 230                 235                 240 


Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys 
                245                 250                 255     


Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn Asn Phe Glu 
            260                 265                 270         


Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser Phe Ala Pro 
        275                 280                 285             


Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu 
    290                 295                 300                 


Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln Phe Asn Lys 
305                 310                 315                 320 


Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly 
                325                 330                 335     


Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg 
            340                 345                 350         


Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly 
        355                 360                 365             


Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu 
    370                 375                 380                 


Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser 
385                 390                 395                 400 


Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met 
                405                 410                 415     


Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr 
            420                 425                 430         


Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser Thr Thr Ala 
        435                 440                 445             


Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val 
    450                 455                 460                 


Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
465                 470                 475                 480 


Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe 
                485                 490                 495     


Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val 
            500                 505                 510         


Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile 
        515                 520                 525             


Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu 
    530                 535                 540                 


Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn 
545                 550                 555                 560 


Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly 
                565                 570                 575     


Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
            580                 585                 590         


Leu 
    


<210>  37
<211>  532
<212>  PRT
<213>  Artificial

<220>
<223>  AAV5 VP3

<400>  37

Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
        35                  40                  45              


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
    50                  55                  60                  


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
65                  70                  75                  80  


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
                85                  90                  95      


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
            100                 105                 110         


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
        115                 120                 125             


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
    130                 135                 140                 


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
145                 150                 155                 160 


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
                165                 170                 175     


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
            180                 185                 190         


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
        195                 200                 205             


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
    210                 215                 220                 


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
225                 230                 235                 240 


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
                245                 250                 255     


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
            260                 265                 270         


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
        275                 280                 285             


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
    290                 295                 300                 


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
305                 310                 315                 320 


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
                325                 330                 335     


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
            340                 345                 350         


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
        355                 360                 365             


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
    370                 375                 380                 


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
385                 390                 395                 400 


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
                405                 410                 415     


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
            420                 425                 430         


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
        435                 440                 445             


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
    450                 455                 460                 


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
465                 470                 475                 480 


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
                485                 490                 495     


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
            500                 505                 510         


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
        515                 520                 525             


Thr Arg Pro Leu 
    530         


<210>  38
<211>  2217
<212>  DNA
<213>  Artificial

<220>
<223>  AAV8 capsid

<400>  38
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc     60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac    120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac    180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac    240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt    300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag    360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct    420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc    480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca    540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga    600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac    660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc    720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa    780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc    840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag    900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac    960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc   1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc   1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac   1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac   1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac   1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg   1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg   1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg   1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat   1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct   1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac   1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc   1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt   1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc   1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc   1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt   1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct   1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag   2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag   2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa   2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa      2217


<210>  39
<211>  782
<212>  PRT
<213>  Artificial

<220>
<223>  AAV8 VP1

<400>  39

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn 
            740                 745                 750         


Leu Ser Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro 
        755                 760                 765             


Lys Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly 
    770                 775                 780         


<210>  40
<211>  601
<212>  PRT
<213>  Artificial

<220>
<223>  AAV8 VP2

<400>  40

Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Pro Ser Pro Gln Arg Ser 
1               5                   10                  15      


Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln Gln Pro Ala Arg 
            20                  25                  30          


Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp 
        35                  40                  45              


Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser Gly Val Gly Pro 
    50                  55                  60                  


Asn Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu 
65                  70                  75                  80  


Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser 
                85                  90                  95      


Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala 
            100                 105                 110         


Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr 
        115                 120                 125             


Ser Gly Gly Ala Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro 
    130                 135                 140                 


Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg 
145                 150                 155                 160 


Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg 
                165                 170                 175     


Leu Ser Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn 
            180                 185                 190         


Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val 
        195                 200                 205             


Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His 
    210                 215                 220                 


Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln 
225                 230                 235                 240 


Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser 
                245                 250                 255     


Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
            260                 265                 270         


Asn Asn Phe Gln Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser 
        275                 280                 285             


Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
    290                 295                 300                 


Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr 
305                 310                 315                 320 


Ala Asn Thr Gln Thr Leu Gly Phe Ser Gln Gly Gly Pro Asn Thr Met 
                325                 330                 335     


Ala Asn Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
            340                 345                 350         


Arg Val Ser Thr Thr Thr Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp 
        355                 360                 365             


Thr Ala Gly Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Ala Asn 
    370                 375                 380                 


Pro Gly Ile Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe 
385                 390                 395                 400 


Pro Ser Asn Gly Ile Leu Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp 
                405                 410                 415     


Asn Ala Asp Tyr Ser Asp Val Met Leu Thr Ser Glu Glu Glu Ile Lys 
            420                 425                 430         


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn 
        435                 440                 445             


Leu Gln Gln Gln Asn Thr Ala Pro Gln Ile Gly Thr Val Asn Ser Gln 
    450                 455                 460                 


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
465                 470                 475                 480 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
                485                 490                 495     


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
            500                 505                 510         


Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn 
        515                 520                 525             


Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
    530                 535                 540                 


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
545                 550                 555                 560 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Ser Val 
                565                 570                 575     


Asp Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile 
            580                 585                 590         


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
        595                 600     


<210>  41
<211>  535
<212>  PRT
<213>  Artificial

<220>
<223>  AAV8 VP3

<400>  41

Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly 
    50                  55                  60                  


Gly Ala Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
65                  70                  75                  80  


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
                85                  90                  95      


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser 
            100                 105                 110         


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly 
        115                 120                 125             


Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr 
    130                 135                 140                 


Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly 
145                 150                 155                 160 


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
                165                 170                 175     


Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
            180                 185                 190         


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
        195                 200                 205             


Phe Gln Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr 
    210                 215                 220                 


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
225                 230                 235                 240 


Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn 
                245                 250                 255     


Thr Gln Thr Leu Gly Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn 
            260                 265                 270         


Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val 
        275                 280                 285             


Ser Thr Thr Thr Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala 
    290                 295                 300                 


Gly Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly 
305                 310                 315                 320 


Ile Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser 
                325                 330                 335     


Asn Gly Ile Leu Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala 
            340                 345                 350         


Asp Tyr Ser Asp Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr 
        355                 360                 365             


Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln 
    370                 375                 380                 


Gln Gln Asn Thr Ala Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala 
385                 390                 395                 400 


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro 
                405                 410                 415     


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
            420                 425                 430         


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
        435                 440                 445             


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser 
    450                 455                 460                 


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
465                 470                 475                 480 


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
                485                 490                 495     


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe 
            500                 505                 510         


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
        515                 520                 525             


Arg Tyr Leu Thr Arg Asn Leu 
    530                 535 


<210>  42
<211>  7494
<212>  DNA
<213>  Artificial

<220>
<223>  pAAV-CMV-CD39-2A-CD73

<400>  42
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca    120

actccatcac taggggttcc tgcggccgca cgcgtcgaca ttgattattg actagttatt    180

aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat    240

aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa    300

taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg    360

actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc    420

cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct    480

tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga    540

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa    600

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc    660

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg    720

aggtctatat aagcagagct ctctggctaa ctagagaacc cactgcttac tggcttatcg    780

aaattaatac gactcactat agggagaccc aagctggcta gttaagcttg gtaccgagct    840

cggatcgcca ccatgagccg catggaggac atcaaagact caaaagtgaa aagattctgc    900

tcaaaaaaca ttctcatcat tctggggttt acatcaattc tcgctgtgat cgcactgatt    960

gccgtcggcc tcactcagaa caagcccctg cctgagaacg tgaagtacgg aatcgtcctg   1020

gacgctggga gctcccacac caatctgtac atctacaagt ggccagcaga gaaagaaaac   1080

gatacaggcg tggtccagca gctggaggaa tgccaggtga agggtcccgg catctccaag   1140

tacgcccaga aaacagacga gattggagct tatctggcag agtgtatgga actgagcaca   1200

gaactcatcc ccacttccaa gcaccatcag acacccgtgt acctgggtgc aactgcagga   1260

atgcgactgc tccgcatgga gtcagaacag agcgccgacg aggtgctggc agctgtcagt   1320

acttcactca aatcttatcc attcgatttt cagggtgcca agatcattac cggccaggag   1380

gaaggagctt acgggtggat cactattaac tatctgctcg ggcggttcac ccaggagcag   1440

tcctggctgt ctctcatcag cgactcccag aagcaggaaa ccttcggcgc tctggatctc   1500

ggcggagcaa gcacccagat cacatttgtg ccacagaata gcacaattga gtcccccgaa   1560

aactctctgc agttccgcct ctacggggag gactacaccg tgtacaccca ctcctttctg   1620

tgctatggca aggaccaggc cctgtggcag aagctcgcta aagatatcca ggtgtctagt   1680

gggggtgtcc tgaaagatcc ctgcttcaat cctggttacg agaaggtggt caacgtgtct   1740

gaactgtatg gaacaccatg tactaagagg ttcgagaaga aactgccctt cgaccagttt   1800

cgaatccagg gaaccgggga ttacgagcag tgtcaccaga gcattctgga actcttcaac   1860

aatagccatt gcccatattc ccagtgtgcc ttcaacggag tgtttctgcc ccctctccac   1920

ggttctttcg gcgcctttag tgctttctac tttgtgatgg acttctttaa gaaagtggct   1980

aagaatagtg tcatctcaca ggagaagatg accgaaatca caaagaactt ctgctctaag   2040

agttgggagg aaaccaagac aagctacccc tccgtgaagg agaaatacct gtcagaatat   2100

tgttttagcg gtgcctacat cctgtccctg ctccagggct ataatttcac cgactcaagc   2160

tgggagcaga tccactttat gggcaagatc aaggattcta acgccggatg gaccctgggg   2220

tacatgctga atctcacaaa catgatccca gctgagcagc cactgtcccc accactccct   2280

cattctacct atattggcct gatggtgctc ttctccctgc tcctggtggc tgtcgcaatc   2340

acaggactgt tcatctactc taagccaagt tatttttgga aagaggcagt gggtagtggc   2400

gccacaaatt tttcactcct gaagcaggcc ggagacgtgg aggaaaaccc agggcccatg   2460

aggcctgcag ccgctaaggt gccaaaatgg ctcctgctcg cactgtccgc cctgctccct   2520

cagtggccag cagcctctgc ttgggagctg actatcctcc acaccaatga tgtgcatagt   2580

agactggaac agacctcaga cgatagcaca aagtgcctga acgccagcct gtgcgtggga   2640

ggagtcgcaa gactgttcac caaggtgcag cagatccgga aagaggaacc taatgtcctg   2700

tttctcgacg caggcgacca gtaccagggc acaatctggt tcaccgtgta caagggactg   2760

gaggtcgctc actttatgaa cattctgggt tacgacgcca tggctctcgg caatcatgag   2820

ttcgacaacg gagtggaagg gctgatcgat cctctgctcc ggaatgtgaa atttccaatc   2880

ctgtcagcta acattaaggc acgaggtcct ctggcacacc agatcagcgg actgttcctc   2940

ccaagtaaag tgctgtcagt cgggggcgag gtggtcggta ttgtgggcta cacctctaag   3000

gaaacaccct tcctgagtaa tcctggcaca aacctcgtgt ttgaggacga aatctctgcc   3060

ctgcagcctg aggtggataa gctgaaaact ctcaatgtca acaagatcat tgcactggga   3120

cacagcgggt tcgaaatgga caagctgatc gcccagaaag tgagaggggt cgatattgtg   3180

gtcggcggac atagtaatac tttcctgtac accggaaacc ctccatcaaa ggaggtgcca   3240

gctgggaaat atccctttat cgtgaccgca gacgatggcc ggcaggtccc agtggtccag   3300

gcatacgcct tcggcaagta cctgggctat ctcaaagtgg agtttgacga taagggaaac   3360

gtcatcacaa gctatgggaa tcccatcctg ctcaactcct ctattcctga agacgccact   3420

atcaaagctg atattaatca gtggaggatc aagctggaca actactccac tcaggagctg   3480

ggaagaacca tcgtgtacct ggatgggtct actcagacct gcaggttcag agaatgtaat   3540

atgggcaacc tgatctgcga cgccatgatt aacaataacc tgcgacaccc cgatgagatg   3600

ttttggaatc atgtgagcat gtgcatcgtc aacgggggtg gcatcaggtc ccccattgac   3660

gagaagaata acggaacaat tacttgggaa aacctggctg cagtgctccc tttcggaggg   3720

acatttgatc tggtccagct caaggggtcc actctgaaga aagccttcga gcactcagtg   3780

catcgctacg gacagagcac cggggaattt ctgcaagtgg gtggcatcca cgtggtctat   3840

gacattaatc gaaaaccctg gaacagggtg gtccagctgg aggtgctctg cactaagtgt   3900

cgagtcccta tctacgagcc actggaaatg gacaaggtgt acaaagtcac cctgcctagc   3960

tatctcgcca acggagggga tggattccag atgattaagg acgagctgct caaacatgat   4020

tctggggacc aggatatctc cgtggtctct gagtacatta gtaagatgaa agtggtctat   4080

cctgctgtgg aaggcaggat caagttcagt gccgcttcac attaccaggg ttcttttcca   4140

ctcgtgattc tctctttttg ggctatgatt ctgattctct aatatcagtg aggatccact   4200

taagggcgaa ttccagcaca ctggcggccg ttagatctac gggtggcatc cctgtgaccc   4260

ctccccagtg cctctcctgg ccctggaagt tgccactcca gtgcccacca gccttgtcct   4320

aataaaatta agttgcatca ttttgtctga ctaggtgtcc ttctataata ttatggggtg   4380

gaggggggtg gtatggagca aggggcaagt tgggaagaca acctgtaggg cctgcggggt   4440

ctattgggaa ccaagctgga gtgcagtggc acaatcttgg ctcactgcaa tctccgcctc   4500

ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg ttgggattcc aggcatgcat   4560

gaccaggctc agctaatttt tgtttttttg gtagagacgg ggtttcacca tattggccag   4620

gctggtctcc aactcctaat ctcaggtgat ctacccacct tggcctccca aattgctggg   4680

attacaggcg tgaaccactg ctcccttccc tgtccttctg attttgtagg taaccacgtg   4740

cggaccgagc ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct   4800

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg   4860

gcctcagtga gcgagcgagc gcgcagctgc ctgcaggggc gcctgatgcg gtattttctc   4920

cttacgcatc tgtgcggtat ttcacaccgc atacgtcaaa gcaaccatag tacgcgccct   4980

gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg   5040

ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg   5100

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac   5160

ggcacctcga ccccaaaaaa cttgatttgg gtgatggttc acgtagtggg ccatcgccct   5220

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt   5280

tccaaactgg aacaacactc aaccctatct cgggctattc ttttgattta taagggattt   5340

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt   5400

ttaacaaaat attaacgttt acaattttat ggtgcactct cagtacaatc tgctctgatg   5460

ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt   5520

gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc   5580

agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat   5640

ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg   5700

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc   5760

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta   5820

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg   5880

ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg   5940

gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac   6000

gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg   6060

acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt   6120

actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg   6180

ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac   6240

cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt   6300

gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag   6360

caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc   6420

aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc   6480

ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta   6540

tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg   6600

ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga   6660

ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac   6720

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa   6780

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat   6840

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc   6900

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg   6960

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc   7020

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg   7080

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg   7140

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa   7200

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg   7260

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga   7320

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct   7380

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca   7440

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgt         7494


<210>  43
<211>  30
<212>  DNA
<213>  Artificial 

<220>
<223>  primer

<400>  43
gcgaagctta ccatgagccg catggaggac                                      30


<210>  44
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  44
gcgagatctt tatcacactg cctctttcca aaaataac                             38


<210>  45
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  45
gcgaagctta ccatgaggcc tgcagccgct aa                                   32


<210>  46
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  46
gcgagatctt tatcagagaa tcagaatcat agccc                                35


<210>  47
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  47
gcgagatctt tatcagaact tgatcctgcc ttccac                               36


<210>  48
<211>  1419
<212>  DNA
<213>  homo sapiens

<400>  48
atggccggga aggtgcggtc actgctgccg ccgctgctgc tggccgccgc gggcctcgcc     60

ggcctcctac tgctgtgcgt ccccacccgc gacgtccggg agccgcccgc cctcaagtat    120

ggcatcgtcc tggatgctgg ttcttcacac acgtccatgt ttatctacaa gtggccggca    180

gacaaggaga acgacacagg cattgtgggc cagcacagct cctgtgatgt tccaggtggg    240

ggcatctcca gctatgcaga caacccttct ggggccagcc agagtcttgt tggatgcctc    300

gaacaggcgc ttcaggatgt gcccaaagag agacacgcgg gcacacccct ctacctggga    360

gccacagcgg gtatgcgcct gctcaacctg accaatccag aggcctcgac cagtgtgctc    420

atggcagtga ctcacacact gacccagtac ccctttgact tccggggtgc acgcatcctc    480

tcgggccaag aagaaggggt gtttggctgg gtgactgcca actacctgct ggagaacttc    540

atcaagtacg gctgggtggg ccggtggttc cggccacgga aggggacact gggggccatg    600

gacctggggg gtgcctctac ccagatcact tttgagacaa ccagtccagc tgaggacaga    660

gccagcgagg tccagctgca tctctacggc cagcactacc gagtctacac ccacagcttc    720

ctctgctatg gccgtgacca ggtcctccag aggctgctgg ccagcgccct ccagacccac    780

ggcttccacc cctgctggcc gaggggcttt tccacccaag tgctgctcgg ggatgtgtac    840

cagtcaccat gcaccatggc ccagcggccc cagaacttca acagcagtgc cagggtcagc    900

ctgtcaggga gcagtgaccc ccacctctgc cgagatctgg tttctgggct cttcagcttc    960

tcctcctgcc ccttctcccg atgctctttc aatggggtct tccagccccc agtggctggg   1020

aactttgtgg ccttctctgc cttcttctac actgtggact ttttgcggac ttcgatgggg   1080

ctgcccgtgg ccaccctgca gcagctggag gcagccgcag tgaatgtctg caaccagacc   1140

tgggctcagc agctgctgag tcgcggctac ggcttcgatg agcgcgcctt cggcggcgtg   1200

atcttccaga agaaggccgc ggacactgca gtgggctggg cgctcggcta catgctgaac   1260

ctgaccaacc tgatccccgc cgacccgccg gggctgcgca agggcacaga cttcagctcc   1320

tgggtcgtcc tcctgctgct cttcgcctcc gcgctcctgg ctgcgcttgt cctgctgctg   1380

cgtcaggtgc actccgccaa gctgccaagc accatttag                          1419


<210>  49
<211>  472
<212>  PRT
<213>  homo sapiens

<400>  49

Met Ala Gly Lys Val Arg Ser Leu Leu Pro Pro Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Gly Leu Ala Gly Leu Leu Leu Leu Cys Val Pro Thr Arg Asp Val 
            20                  25                  30          


Arg Glu Pro Pro Ala Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser 
        35                  40                  45              


Ser His Thr Ser Met Phe Ile Tyr Lys Trp Pro Ala Asp Lys Glu Asn 
    50                  55                  60                  


Asp Thr Gly Ile Val Gly Gln His Ser Ser Cys Asp Val Pro Gly Gly 
65                  70                  75                  80  


Gly Ile Ser Ser Tyr Ala Asp Asn Pro Ser Gly Ala Ser Gln Ser Leu 
                85                  90                  95      


Val Gly Cys Leu Glu Gln Ala Leu Gln Asp Val Pro Lys Glu Arg His 
            100                 105                 110         


Ala Gly Thr Pro Leu Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu 
        115                 120                 125             


Asn Leu Thr Asn Pro Glu Ala Ser Thr Ser Val Leu Met Ala Val Thr 
    130                 135                 140                 


His Thr Leu Thr Gln Tyr Pro Phe Asp Phe Arg Gly Ala Arg Ile Leu 
145                 150                 155                 160 


Ser Gly Gln Glu Glu Gly Val Phe Gly Trp Val Thr Ala Asn Tyr Leu 
                165                 170                 175     


Leu Glu Asn Phe Ile Lys Tyr Gly Trp Val Gly Arg Trp Phe Arg Pro 
            180                 185                 190         


Arg Lys Gly Thr Leu Gly Ala Met Asp Leu Gly Gly Ala Ser Thr Gln 
        195                 200                 205             


Ile Thr Phe Glu Thr Thr Ser Pro Ala Glu Asp Arg Ala Ser Glu Val 
    210                 215                 220                 


Gln Leu His Leu Tyr Gly Gln His Tyr Arg Val Tyr Thr His Ser Phe 
225                 230                 235                 240 


Leu Cys Tyr Gly Arg Asp Gln Val Leu Gln Arg Leu Leu Ala Ser Ala 
                245                 250                 255     


Leu Gln Thr His Gly Phe His Pro Cys Trp Pro Arg Gly Phe Ser Thr 
            260                 265                 270         


Gln Val Leu Leu Gly Asp Val Tyr Gln Ser Pro Cys Thr Met Ala Gln 
        275                 280                 285             


Arg Pro Gln Asn Phe Asn Ser Ser Ala Arg Val Ser Leu Ser Gly Ser 
    290                 295                 300                 


Ser Asp Pro His Leu Cys Arg Asp Leu Val Ser Gly Leu Phe Ser Phe 
305                 310                 315                 320 


Ser Ser Cys Pro Phe Ser Arg Cys Ser Phe Asn Gly Val Phe Gln Pro 
                325                 330                 335     


Pro Val Ala Gly Asn Phe Val Ala Phe Ser Ala Phe Phe Tyr Thr Val 
            340                 345                 350         


Asp Phe Leu Arg Thr Ser Met Gly Leu Pro Val Ala Thr Leu Gln Gln 
        355                 360                 365             


Leu Glu Ala Ala Ala Val Asn Val Cys Asn Gln Thr Trp Ala Gln Gln 
    370                 375                 380                 


Leu Leu Ser Arg Gly Tyr Gly Phe Asp Glu Arg Ala Phe Gly Gly Val 
385                 390                 395                 400 


Ile Phe Gln Lys Lys Ala Ala Asp Thr Ala Val Gly Trp Ala Leu Gly 
                405                 410                 415     


Tyr Met Leu Asn Leu Thr Asn Leu Ile Pro Ala Asp Pro Pro Gly Leu 
            420                 425                 430         


Arg Lys Gly Thr Asp Phe Ser Ser Trp Val Val Leu Leu Leu Leu Phe 
        435                 440                 445             


Ala Ser Ala Leu Leu Ala Ala Leu Val Leu Leu Leu Arg Gln Val His 
    450                 455                 460                 


Ser Ala Lys Leu Pro Ser Thr Ile 
465                 470         


<210>  50
<211>  1488
<212>  DNA
<213>  Homo sapiens

<400>  50
atggggctgt cccggaagga gcaggtcttc ttggccctgc tgggggcctc gggggtctca     60

ggcctcacgg cactcattct cctcctggtg gaggccacca gcgtgctcct gcccacagac    120

atcaagtttg ggatcgtgtt tgatgcgggc tcctcccaca cgtccctctt cctgtatcag    180

tggctggcga acaaggagaa tggcacgggt gtggtcagcc aggccctggc ctgccaggtg    240

gaagggcctg gaatctcctc ctacacttct aatgctgcac aggctggtga gagcctgcag    300

ggctgcttgg aggaggcgct ggtgctgatc ccagaggccc agcatcggaa aacacccacg    360

ttcctggggg ccacggctgg catgaggttg ctcagccgga agaacagctc tcaggccagg    420

gacatctttg cagcagtcac ccaggtcctg ggccggtctc ccgtggactt ttggggtgcc    480

gagctcctgg ccgggcaggc cgaaggtgcc tttggttgga tcactgtcaa ctacggcttg    540

gggacgctgg tcaagtactc cttcactgga gaatggatcc agcctccgga ggagatgctg    600

gtgggtgccc tggacatggg aggggcctcc acccagatca cgttcgtgcc tgggggcccc    660

atcttggaca agagcaccca ggccgatttt cgcctctacg gctccgacta cagcgtctac    720

actcacagct acctgtgctt tggacgggac cagatgctga gcaggctcct cgtggggctg    780

gtacagagcc gcccggctgc cctgctccgt cacccgtgct acctcagcgg ctaccagacc    840

acactggccc tgggcccgct gtatgagtca ccctgtgtcc acgccacgcc cccgctgagc    900

ctcccccaga acctcacagt tgaagggaca ggcaaccctg gagcctgcgt ctcagccatc    960

cgggaacttt tcaacttctc cagctgccag ggccaggagg actgcgcctt tgacggggtc   1020

taccagcccc cgctgcgggg ccagttctat gccttctcca acttctacta caccttccac   1080

ttcctgaacc tcacctccag gcagcccctg agcacggtca acgccaccat ctgggagttt   1140

tgccagaggc cctggaaact ggtggaggcc agctaccctg ggcaggaccg ctggctgcgg   1200

gactactgtg cctcaggcct gtacatcctc accctcctgc acgagggcta cgggttcagc   1260

gaggagacct ggcccagcct cgagttccga aagcaggcgg gcggtgtgga cattggctgg   1320

acactgggct acatgctgaa cctgaccggg atgatcccgg ccgatgcgcc ggctcagtgg   1380

cgggcagaga gctacggcgt ctgggtggcc aaagtggtgt tcatggtgct ggccctggtg   1440

gcggtggtgg gggctgcctt ggtccagctc ttctggttgc aggactag                1488


<210>  51
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Gly Leu Ser Arg Lys Glu Gln Val Phe Leu Ala Leu Leu Gly Ala 
1               5                   10                  15      


Ser Gly Val Ser Gly Leu Thr Ala Leu Ile Leu Leu Leu Val Glu Ala 
            20                  25                  30          


Thr Ser Val Leu Leu Pro Thr Asp Ile Lys Phe Gly Ile Val Phe Asp 
        35                  40                  45              


Ala Gly Ser Ser His Thr Ser Leu Phe Leu Tyr Gln Trp Leu Ala Asn 
    50                  55                  60                  


Lys Glu Asn Gly Thr Gly Val Val Ser Gln Ala Leu Ala Cys Gln Val 
65                  70                  75                  80  


Glu Gly Pro Gly Ile Ser Ser Tyr Thr Ser Asn Ala Ala Gln Ala Gly 
                85                  90                  95      


Glu Ser Leu Gln Gly Cys Leu Glu Glu Ala Leu Val Leu Ile Pro Glu 
            100                 105                 110         


Ala Gln His Arg Lys Thr Pro Thr Phe Leu Gly Ala Thr Ala Gly Met 
        115                 120                 125             


Arg Leu Leu Ser Arg Lys Asn Ser Ser Gln Ala Arg Asp Ile Phe Ala 
    130                 135                 140                 


Ala Val Thr Gln Val Leu Gly Arg Ser Pro Val Asp Phe Trp Gly Ala 
145                 150                 155                 160 


Glu Leu Leu Ala Gly Gln Ala Glu Gly Ala Phe Gly Trp Ile Thr Val 
                165                 170                 175     


Asn Tyr Gly Leu Gly Thr Leu Val Lys Tyr Ser Phe Thr Gly Glu Trp 
            180                 185                 190         


Ile Gln Pro Pro Glu Glu Met Leu Val Gly Ala Leu Asp Met Gly Gly 
        195                 200                 205             


Ala Ser Thr Gln Ile Thr Phe Val Pro Gly Gly Pro Ile Leu Asp Lys 
    210                 215                 220                 


Ser Thr Gln Ala Asp Phe Arg Leu Tyr Gly Ser Asp Tyr Ser Val Tyr 
225                 230                 235                 240 


Thr His Ser Tyr Leu Cys Phe Gly Arg Asp Gln Met Leu Ser Arg Leu 
                245                 250                 255     


Leu Val Gly Leu Val Gln Ser Arg Pro Ala Ala Leu Leu Arg His Pro 
            260                 265                 270         


Cys Tyr Leu Ser Gly Tyr Gln Thr Thr Leu Ala Leu Gly Pro Leu Tyr 
        275                 280                 285             


Glu Ser Pro Cys Val His Ala Thr Pro Pro Leu Ser Leu Pro Gln Asn 
    290                 295                 300                 


Leu Thr Val Glu Gly Thr Gly Asn Pro Gly Ala Cys Val Ser Ala Ile 
305                 310                 315                 320 


Arg Glu Leu Phe Asn Phe Ser Ser Cys Gln Gly Gln Glu Asp Cys Ala 
                325                 330                 335     


Phe Asp Gly Val Tyr Gln Pro Pro Leu Arg Gly Gln Phe Tyr Ala Phe 
            340                 345                 350         


Ser Asn Phe Tyr Tyr Thr Phe His Phe Leu Asn Leu Thr Ser Arg Gln 
        355                 360                 365             


Pro Leu Ser Thr Val Asn Ala Thr Ile Trp Glu Phe Cys Gln Arg Pro 
    370                 375                 380                 


Trp Lys Leu Val Glu Ala Ser Tyr Pro Gly Gln Asp Arg Trp Leu Arg 
385                 390                 395                 400 


Asp Tyr Cys Ala Ser Gly Leu Tyr Ile Leu Thr Leu Leu His Glu Gly 
                405                 410                 415     


Tyr Gly Phe Ser Glu Glu Thr Trp Pro Ser Leu Glu Phe Arg Lys Gln 
            420                 425                 430         


Ala Gly Gly Val Asp Ile Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu 
        435                 440                 445             


Thr Gly Met Ile Pro Ala Asp Ala Pro Ala Gln Trp Arg Ala Glu Ser 
    450                 455                 460                 


Tyr Gly Val Trp Val Ala Lys Val Val Phe Met Val Leu Ala Leu Val 
465                 470                 475                 480 


Ala Val Val Gly Ala Ala Leu Val Gln Leu Phe Trp Leu Gln Asp 
                485                 490                 495 


<210>  52
<211>  3822
<212>  DNA
<213>  Artificial

<220>
<223>  Fc-tagged CD73-39 fusion DNA derived from mus musculus

<400>  52
atgggctggt cctgcatcat cctgttcctg gtcgcaaccg caactggcgt ccattcagat     60

aaaactcata cttgtccacc ttgtcctgct cctgagctgc tgggaggacc aagcgtgttc    120

ctgtttcccc ctaagccaaa agacaccctg atgatcagcc ggactcccga agtcacctgc    180

gtggtcgtgg acgtgagcca cgaggatccc gaagtcaagt tcaactggta cgtggatggc    240

gtcgaggtgc ataatgccaa gacaaaacct agggaggaac agtacaactc cacctatcgc    300

gtcgtgtctg tcctgacagt gctgcaccag gactggctga acggcaaaga gtataagtgc    360

aaagtgtcca ataaggccct gcccgctcct atcgagaaaa ctatttctaa ggctaaaggg    420

cagccacgag aaccacaggt gtacaccctg ccaccaagcc gggaggaaat gacaaagaac    480

caggtcagtc tgacttgtct ggtgaaagga ttctatccta gcgacattgc agtggagtgg    540

gaatccaatg gccagccaga aaacaattac aagaccacac ctccagtgct ggactctgat    600

gggagtttct ttctgtatag taagctgaca gtggataaat cacggtggca gcagggaaac    660

gtcttttctt gcagtgtgat gcatgaggca ctgcacaatc attacactca gaagtcactg    720

agcctgtccc ccggcaaagc cgctgcaaat agctccatcg acctgatttc agtccccgtg    780

gatagccgga gacctgcctg taagattcct aacgacctga aacagaaagt gatgaaccac    840

gactacaaag acgacgacga caaagagtgg gaactgacaa tcctgcacac caatgacgtg    900

catagtcggc tcgagcagac atcagacgat agcactaagt gcctgaacgc cagcctgtgc    960

gtgggaggag tcgcaagact gttcacaaag gtgcagcaga tccggaaaga ggaacctaat   1020

gtcctgtttc tcgacgctgg cgatcagtac cagggaacaa tctggttcac cgtgtacaag   1080

ggcctggagg tcgcacactt tatgaacatt ctggggtacg acgctatggc actcggtaat   1140

catgagttcg acaacggggt ggaaggtctg atcgatcctc tgctccggaa tgtgaaattt   1200

ccaatcctgt cagcaaacat taaggcacga ggaccactgg cacaccagat cagcggtctg   1260

ttcctcccct ccaaagtgct gtctgtcggg ggcgaggtgg tcggcattgt gggatacacc   1320

tctaaggaaa cacccttcct gagtaatcct ggcactaacc tcgtgtttga ggacgaaatc   1380

agtgctctgc agcccgaggt ggataagctg aaaaccctca atgtcaacaa gatcattgct   1440

ctggggcact ctggtttcga aatggacaag ctgatcgcac agaaagtgag aggcgtcgat   1500

attgtggtcg gcggacatag taatactttc ctgtacaccg gcaacccccc ttcaaaggag   1560

gtgccagccg gaaaatatcc ctttatcgtg accgctgacg atggacggca ggtccctgtg   1620

gtccaggcct acgctttcgg caagtacctg ggatatctca aagtggagtt tgacgataag   1680

ggcaacgtca ttacatccta tggaaatccc atcctgctca acagctccat tcctgaagac   1740

gctactatca aagcagatat taatcagtgg aggatcaagc tggacaacta ctccactcag   1800

gagctgggga gaaccatcgt gtacctggat ggctctaccc agacatgcag gttcagagaa   1860

tgtaatatgg gcaacctgat ctgcgacgcc atgattaaca ataacctgcg acacccagat   1920

gagatgtttt ggaatcatgt gagcatgtgc atcgtcaacg ggggtggcat caggtcccct   1980

attgacgaga agaataacgg aactattacc tgggaaaacc tggccgctgt gctcccattc   2040

ggagggacat ttgatctggt gcagctcaag gggagcactc tgaagaaagc cttcgagcac   2100

tcagtgcatc gctacgggca gagcacaggt gaatttctgc aagtgggtgg catccacgtg   2160

gtctatgaca ttaatcgaaa accatggaac agggtggtcc agctggaggt gctctgcacc   2220

aagtgtcgag tcccaatcta cgagcccctg gaaatggaca aggtgtacaa agtcacactg   2280

cccagctatc tcgccaacgg aggggatgga ttccagatga ttaaggacga gctgctcaaa   2340

catgattctg gggaccagga tatctccgtg gtctctgagt acattagtaa gatgaaagtg   2400

gtctatccag ctgtggaagg caggatcaag ttcgctagcg gtggaggagc aggaggtgga   2460

gctggagggg gtgcaggcgg aggggccggt ggcggaaccg gtactcagaa caagcctctg   2520

ccagagaacg tgaagtacgg gatcgtcctg gacgccggtt ctagtcacac caatctctac   2580

atctacaagt ggcccgctga gaaagaaaac gatacaggcg tggtccagca gctggaggaa   2640

tgccaggtga aggggcctgg tatctctaag tacgcccaga aaaccgacga gattggagct   2700

tatctggcag agtgtatgga actgtccacc gaactcatcc caacatctaa gcaccatcag   2760

acacccgtgt acctgggagc aactgcagga atgcgactgc tccgcatgga gagtgaacag   2820

tcagctgacg aggtgctggc agccgtcagt acttcactca aaagctatcc cttcgatttt   2880

cagggcgcaa agatcattac cggacaggag gaaggcgcct acggatggat cactattaac   2940

tatctgctcg ggaggttcac ccaggagcag agctggctgt ccctcatcag cgactcccag   3000

aagcaggaaa cattcggcgc tctggatctc gggggtgcat ctactcagat cacctttgtg   3060

cctcagaata gtactattga gtcaccagaa aacagcctgc agttcagact ctacggcgag   3120

gactacacag tgtatactca cagctttctg tgctatggaa aggaccaggc cctgtggcag   3180

aagctcgcta aagatatcca ggtgtcaagc ggcggagtcc tgaaagatcc ttgcttcaat   3240

ccagggtacg agaaggtggt caacgtgtcc gaactgtatg gcaccccctg tacaaagagg   3300

ttcgagaaga aactgccttt cgaccagttt cgaatccagg gcaccggaga ttacgagcag   3360

tgtcaccagt ctattctgga actcttcaat aactcccatt gcccctattc tcagtgtgcc   3420

ttcaacggcg tgtttctgcc acccctccac gggagtttcg gtgccttttc agctttctac   3480

tttgtgatgg acttctttaa gaaagtggct aagaattctg tcatcagtca ggagaagatg   3540

actgaaatta ccaagaactt ctgctctaaa agttgggagg aaaccaagac atcatatcct   3600

agcgtgaagg agaaatacct gagcgaatat tgtttttccg gagcctacat cctgtccctg   3660

ctccaggggt ataatttcac agactcctct tgggagcaga tccacttcat gggcaagatc   3720

aaggatagca acgcagggtg gaccctgggt tacatgctga atctcacaaa catgatccca   3780

gccgaacagc ccctgtcccc tccactgcct cactccacct aa                      3822


<210>  53
<211>  1273
<212>  PRT
<213>  Artificial

<220>
<223>  Fc-tagged CD73-39 fusion protein derived from mus musculus

<400>  53

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys Ala Ala Ala Asn Ser Ser Ile Asp Leu Ile 
                245                 250                 255     


Ser Val Pro Val Asp Ser Arg Arg Pro Ala Cys Lys Ile Pro Asn Asp 
            260                 265                 270         


Leu Lys Gln Lys Val Met Asn His Asp Tyr Lys Asp Asp Asp Asp Lys 
        275                 280                 285             


Glu Trp Glu Leu Thr Ile Leu His Thr Asn Asp Val His Ser Arg Leu 
    290                 295                 300                 


Glu Gln Thr Ser Asp Asp Ser Thr Lys Cys Leu Asn Ala Ser Leu Cys 
305                 310                 315                 320 


Val Gly Gly Val Ala Arg Leu Phe Thr Lys Val Gln Gln Ile Arg Lys 
                325                 330                 335     


Glu Glu Pro Asn Val Leu Phe Leu Asp Ala Gly Asp Gln Tyr Gln Gly 
            340                 345                 350         


Thr Ile Trp Phe Thr Val Tyr Lys Gly Leu Glu Val Ala His Phe Met 
        355                 360                 365             


Asn Ile Leu Gly Tyr Asp Ala Met Ala Leu Gly Asn His Glu Phe Asp 
    370                 375                 380                 


Asn Gly Val Glu Gly Leu Ile Asp Pro Leu Leu Arg Asn Val Lys Phe 
385                 390                 395                 400 


Pro Ile Leu Ser Ala Asn Ile Lys Ala Arg Gly Pro Leu Ala His Gln 
                405                 410                 415     


Ile Ser Gly Leu Phe Leu Pro Ser Lys Val Leu Ser Val Gly Gly Glu 
            420                 425                 430         


Val Val Gly Ile Val Gly Tyr Thr Ser Lys Glu Thr Pro Phe Leu Ser 
        435                 440                 445             


Asn Pro Gly Thr Asn Leu Val Phe Glu Asp Glu Ile Ser Ala Leu Gln 
    450                 455                 460                 


Pro Glu Val Asp Lys Leu Lys Thr Leu Asn Val Asn Lys Ile Ile Ala 
465                 470                 475                 480 


Leu Gly His Ser Gly Phe Glu Met Asp Lys Leu Ile Ala Gln Lys Val 
                485                 490                 495     


Arg Gly Val Asp Ile Val Val Gly Gly His Ser Asn Thr Phe Leu Tyr 
            500                 505                 510         


Thr Gly Asn Pro Pro Ser Lys Glu Val Pro Ala Gly Lys Tyr Pro Phe 
        515                 520                 525             


Ile Val Thr Ala Asp Asp Gly Arg Gln Val Pro Val Val Gln Ala Tyr 
    530                 535                 540                 


Ala Phe Gly Lys Tyr Leu Gly Tyr Leu Lys Val Glu Phe Asp Asp Lys 
545                 550                 555                 560 


Gly Asn Val Ile Thr Ser Tyr Gly Asn Pro Ile Leu Leu Asn Ser Ser 
                565                 570                 575     


Ile Pro Glu Asp Ala Thr Ile Lys Ala Asp Ile Asn Gln Trp Arg Ile 
            580                 585                 590         


Lys Leu Asp Asn Tyr Ser Thr Gln Glu Leu Gly Arg Thr Ile Val Tyr 
        595                 600                 605             


Leu Asp Gly Ser Thr Gln Thr Cys Arg Phe Arg Glu Cys Asn Met Gly 
    610                 615                 620                 


Asn Leu Ile Cys Asp Ala Met Ile Asn Asn Asn Leu Arg His Pro Asp 
625                 630                 635                 640 


Glu Met Phe Trp Asn His Val Ser Met Cys Ile Val Asn Gly Gly Gly 
                645                 650                 655     


Ile Arg Ser Pro Ile Asp Glu Lys Asn Asn Gly Thr Ile Thr Trp Glu 
            660                 665                 670         


Asn Leu Ala Ala Val Leu Pro Phe Gly Gly Thr Phe Asp Leu Val Gln 
        675                 680                 685             


Leu Lys Gly Ser Thr Leu Lys Lys Ala Phe Glu His Ser Val His Arg 
    690                 695                 700                 


Tyr Gly Gln Ser Thr Gly Glu Phe Leu Gln Val Gly Gly Ile His Val 
705                 710                 715                 720 


Val Tyr Asp Ile Asn Arg Lys Pro Trp Asn Arg Val Val Gln Leu Glu 
                725                 730                 735     


Val Leu Cys Thr Lys Cys Arg Val Pro Ile Tyr Glu Pro Leu Glu Met 
            740                 745                 750         


Asp Lys Val Tyr Lys Val Thr Leu Pro Ser Tyr Leu Ala Asn Gly Gly 
        755                 760                 765             


Asp Gly Phe Gln Met Ile Lys Asp Glu Leu Leu Lys His Asp Ser Gly 
    770                 775                 780                 


Asp Gln Asp Ile Ser Val Val Ser Glu Tyr Ile Ser Lys Met Lys Val 
785                 790                 795                 800 


Val Tyr Pro Ala Val Glu Gly Arg Ile Lys Phe Ala Ser Gly Gly Gly 
                805                 810                 815     


Ala Gly Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly 
            820                 825                 830         


Thr Gly Thr Gln Asn Lys Pro Leu Pro Glu Asn Val Lys Tyr Gly Ile 
        835                 840                 845             


Val Leu Asp Ala Gly Ser Ser His Thr Asn Leu Tyr Ile Tyr Lys Trp 
    850                 855                 860                 


Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val Gln Gln Leu Glu Glu 
865                 870                 875                 880 


Cys Gln Val Lys Gly Pro Gly Ile Ser Lys Tyr Ala Gln Lys Thr Asp 
                885                 890                 895     


Glu Ile Gly Ala Tyr Leu Ala Glu Cys Met Glu Leu Ser Thr Glu Leu 
            900                 905                 910         


Ile Pro Thr Ser Lys His His Gln Thr Pro Val Tyr Leu Gly Ala Thr 
        915                 920                 925             


Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Gln Ser Ala Asp Glu 
    930                 935                 940                 


Val Leu Ala Ala Val Ser Thr Ser Leu Lys Ser Tyr Pro Phe Asp Phe 
945                 950                 955                 960 


Gln Gly Ala Lys Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp 
                965                 970                 975     


Ile Thr Ile Asn Tyr Leu Leu Gly Arg Phe Thr Gln Glu Gln Ser Trp 
            980                 985                 990         


Leu Ser Leu Ile Ser Asp Ser Gln  Lys Gln Glu Thr Phe  Gly Ala Leu 
        995                 1000                 1005             


Asp Leu  Gly Gly Ala Ser Thr  Gln Ile Thr Phe Val  Pro Gln Asn 
    1010                 1015                 1020             


Ser Thr  Ile Glu Ser Pro Glu  Asn Ser Leu Gln Phe  Arg Leu Tyr 
    1025                 1030                 1035             


Gly Glu  Asp Tyr Thr Val Tyr  Thr His Ser Phe Leu  Cys Tyr Gly 
    1040                 1045                 1050             


Lys Asp  Gln Ala Leu Trp Gln  Lys Leu Ala Lys Asp  Ile Gln Val 
    1055                 1060                 1065             


Ser Ser  Gly Gly Val Leu Lys  Asp Pro Cys Phe Asn  Pro Gly Tyr 
    1070                 1075                 1080             


Glu Lys  Val Val Asn Val Ser  Glu Leu Tyr Gly Thr  Pro Cys Thr 
    1085                 1090                 1095             


Lys Arg  Phe Glu Lys Lys Leu  Pro Phe Asp Gln Phe  Arg Ile Gln 
    1100                 1105                 1110             


Gly Thr  Gly Asp Tyr Glu Gln  Cys His Gln Ser Ile  Leu Glu Leu 
    1115                 1120                 1125             


Phe Asn  Asn Ser His Cys Pro  Tyr Ser Gln Cys Ala  Phe Asn Gly 
    1130                 1135                 1140             


Val Phe  Leu Pro Pro Leu His  Gly Ser Phe Gly Ala  Phe Ser Ala 
    1145                 1150                 1155             


Phe Tyr  Phe Val Met Asp Phe  Phe Lys Lys Val Ala  Lys Asn Ser 
    1160                 1165                 1170             


Val Ile  Ser Gln Glu Lys Met  Thr Glu Ile Thr Lys  Asn Phe Cys 
    1175                 1180                 1185             


Ser Lys  Ser Trp Glu Glu Thr  Lys Thr Ser Tyr Pro  Ser Val Lys 
    1190                 1195                 1200             


Glu Lys  Tyr Leu Ser Glu Tyr  Cys Phe Ser Gly Ala  Tyr Ile Leu 
    1205                 1210                 1215             


Ser Leu  Leu Gln Gly Tyr Asn  Phe Thr Asp Ser Ser  Trp Glu Gln 
    1220                 1225                 1230             


Ile His  Phe Met Gly Lys Ile  Lys Asp Ser Asn Ala  Gly Trp Thr 
    1235                 1240                 1245             


Leu Gly  Tyr Met Leu Asn Leu  Thr Asn Met Ile Pro  Ala Glu Gln 
    1250                 1255                 1260             


Pro Leu  Ser Pro Pro Leu Pro  His Ser Thr 
    1265                 1270             


<210>  54
<211>  3330
<212>  DNA
<213>  Artificial

<220>
<223>  CD39-2A-CD73 derived from mus musculus, codon optimized

<400>  54
atgagccgca tggaggacat caaagactca aaagtgaaaa gattctgctc aaaaaacatt     60

ctcatcattc tggggtttac atcaattctc gctgtgatcg cactgattgc cgtcggcctc    120

actcagaaca agcccctgcc tgagaacgtg aagtacggaa tcgtcctgga cgctgggagc    180

tcccacacca atctgtacat ctacaagtgg ccagcagaga aagaaaacga tacaggcgtg    240

gtccagcagc tggaggaatg ccaggtgaag ggtcccggca tctccaagta cgcccagaaa    300

acagacgaga ttggagctta tctggcagag tgtatggaac tgagcacaga actcatcccc    360

acttccaagc accatcagac acccgtgtac ctgggtgcaa ctgcaggaat gcgactgctc    420

cgcatggagt cagaacagag cgccgacgag gtgctggcag ctgtcagtac ttcactcaaa    480

tcttatccat tcgattttca gggtgccaag atcattaccg gccaggagga aggagcttac    540

gggtggatca ctattaacta tctgctcggg cggttcaccc aggagcagtc ctggctgtct    600

ctcatcagcg actcccagaa gcaggaaacc ttcggcgctc tggatctcgg cggagcaagc    660

acccagatca catttgtgcc acagaatagc acaattgagt cccccgaaaa ctctctgcag    720

ttccgcctct acggggagga ctacaccgtg tacacccact cctttctgtg ctatggcaag    780

gaccaggccc tgtggcagaa gctcgctaaa gatatccagg tgtctagtgg gggtgtcctg    840

aaagatccct gcttcaatcc tggttacgag aaggtggtca acgtgtctga actgtatgga    900

acaccatgta ctaagaggtt cgagaagaaa ctgcccttcg accagtttcg aatccaggga    960

accggggatt acgagcagtg tcaccagagc attctggaac tcttcaacaa tagccattgc   1020

ccatattccc agtgtgcctt caacggagtg tttctgcccc ctctccacgg ttctttcggc   1080

gcctttagtg ctttctactt tgtgatggac ttctttaaga aagtggctaa gaatagtgtc   1140

atctcacagg agaagatgac cgaaatcaca aagaacttct gctctaagag ttgggaggaa   1200

accaagacaa gctacccctc cgtgaaggag aaatacctgt cagaatattg ttttagcggt   1260

gcctacatcc tgtccctgct ccagggctat aatttcaccg actcaagctg ggagcagatc   1320

cactttatgg gcaagatcaa ggattctaac gccggatgga ccctggggta catgctgaat   1380

ctcacaaaca tgatcccagc tgagcagcca ctgtccccac cactccctca ttctacctat   1440

attggcctga tggtgctctt ctccctgctc ctggtggctg tcgcaatcac aggactgttc   1500

atctactcta agccaagtta tttttggaaa gaggcagtgg gtagtggcgc cacaaatttt   1560

tcactcctga agcaggccgg agacgtggag gaaaacccag ggcccatgag gcctgcagcc   1620

gctaaggtgc caaaatggct cctgctcgca ctgtccgccc tgctccctca gtggccagca   1680

gcctctgctt gggagctgac tatcctccac accaatgatg tgcatagtag actggaacag   1740

acctcagacg atagcacaaa gtgcctgaac gccagcctgt gcgtgggagg agtcgcaaga   1800

ctgttcacca aggtgcagca gatccggaaa gaggaaccta atgtcctgtt tctcgacgca   1860

ggcgaccagt accagggcac aatctggttc accgtgtaca agggactgga ggtcgctcac   1920

tttatgaaca ttctgggtta cgacgccatg gctctcggca atcatgagtt cgacaacgga   1980

gtggaagggc tgatcgatcc tctgctccgg aatgtgaaat ttccaatcct gtcagctaac   2040

attaaggcac gaggtcctct ggcacaccag atcagcggac tgttcctccc aagtaaagtg   2100

ctgtcagtcg ggggcgaggt ggtcggtatt gtgggctaca cctctaagga aacacccttc   2160

ctgagtaatc ctggcacaaa cctcgtgttt gaggacgaaa tctctgccct gcagcctgag   2220

gtggataagc tgaaaactct caatgtcaac aagatcattg cactgggaca cagcgggttc   2280

gaaatggaca agctgatcgc ccagaaagtg agaggggtcg atattgtggt cggcggacat   2340

agtaatactt tcctgtacac cggaaaccct ccatcaaagg aggtgccagc tgggaaatat   2400

ccctttatcg tgaccgcaga cgatggccgg caggtcccag tggtccaggc atacgccttc   2460

ggcaagtacc tgggctatct caaagtggag tttgacgata agggaaacgt catcacaagc   2520

tatgggaatc ccatcctgct caactcctct attcctgaag acgccactat caaagctgat   2580

attaatcagt ggaggatcaa gctggacaac tactccactc aggagctggg aagaaccatc   2640

gtgtacctgg atgggtctac tcagacctgc aggttcagag aatgtaatat gggcaacctg   2700

atctgcgacg ccatgattaa caataacctg cgacaccccg atgagatgtt ttggaatcat   2760

gtgagcatgt gcatcgtcaa cgggggtggc atcaggtccc ccattgacga gaagaataac   2820

ggaacaatta cttgggaaaa cctggctgca gtgctccctt tcggagggac atttgatctg   2880

gtccagctca aggggtccac tctgaagaaa gccttcgagc actcagtgca tcgctacgga   2940

cagagcaccg gggaatttct gcaagtgggt ggcatccacg tggtctatga cattaatcga   3000

aaaccctgga acagggtggt ccagctggag gtgctctgca ctaagtgtcg agtccctatc   3060

tacgagccac tggaaatgga caaggtgtac aaagtcaccc tgcctagcta tctcgccaac   3120

ggaggggatg gattccagat gattaaggac gagctgctca aacatgattc tggggaccag   3180

gatatctccg tggtctctga gtacattagt aagatgaaag tggtctatcc tgctgtggaa   3240

ggcaggatca agttcagtgc cgcttcacat taccagggtt cttttccact cgtgattctc   3300

tctttttggg ctatgattct gattctctaa                                    3330


<210>  55
<211>  1533
<212>  DNA
<213>  Artificial

<220>
<223>  CD39 cDNA derived from homo sapiens, codon optimized

<400>  55
atggaagata ccaaagagag caacgtgaag actttctgta gcaagaacat cctcgcaatc     60

ctggggttta gcagcatcat cgccgtcatc gcactgctcg ccgtgggcct cacccagaac    120

aaggccctgc ctgagaatgt gaaatacggc attgtcctgg acgctggaag ctcccacacc    180

agcctgtaca tctataagtg gcctgctgag aaagaaaacg atacaggggt ggtccatcag    240

gtggaggaat gccgggtcaa ggggccaggt atttccaagt tcgtgcagaa agtcaatgag    300

atcggcatct acctgacaga ctgtatggag agggctagag aagtgatccc taggtctcag    360

caccaggaaa ctccagtcta tctgggagca accgctggta tgcgactgct ccgcatggag    420

agtgaggaac tcgcagaccg agtgctggat gtggtcgaaa ggtctctgag taactacccc    480

ttcgactttc agggggcacg catcattact ggtcaggagg aaggggccta cggttggatc    540

accattaatt atctgctcgg caagttttct cagaaaaccc gatggttcag tattgtgcct    600

tatgagacaa acaatcagga aacttttgga gccctcgatc tgggcggagc ttccacccag    660

gtgacattcg tcccccagaa ccagactatc gagtctcctg acaatgccct ccagtttagg    720

ctgtacggga aggattacaa cgtgtatacc cactctttcc tgtgctatgg taaagaccag    780

gcactctggc agaagctggc caaagatatt caggtggcta gcaacgagat cctgagagac    840

ccatgctttc atcccggata caagaaagtg gtcaatgtct ccgatctgta taagactcca    900

tgtaccaaac ggttcgagat gacactgccc ttccagcagt ttgaaatcca gggcattgga    960

aactaccagc agtgtcatca gtctattctc gagctgttta acactagtta ctgcccatat   1020

tcacagtgtg ctttcaatgg aatctttctc ccccctctgc agggcgattt cggagctttt   1080

agcgcattct actttgtgat gaagtttctc aatctgacct ccgagaaggt gtctcaggag   1140

aaagtcacag aaatgatgaa gaaattctgc gctcagccct gggaggaaat taagactagc   1200

tatgcagggg tgaaggagaa atacctgagc gaatattgtt tctccggcac atacatcctg   1260

tcactgctcc tgcagggata tcactttact gccgacagct gggagcacat ccatttcatt   1320

ggcaagatcc agggatccga tgcagggtgg acactgggtt acatgctcaa cctgactaat   1380

atgatccctg ccgaacagcc actcagtacc cccctgtcac atagcacata cgtgttcctg   1440

atggtcctgt tttcactcgt gctgttcaca gtcgctatca ttggtctgct catttttcac   1500

aagccctctt atttctggaa ggacatggtc tga                                1533


<210>  56
<211>  1725
<212>  DNA
<213>  Artificial

<220>
<223>  CD73 cDNA derived from homo sapiens, codon optimized

<400>  56
atgtgcccta gagccgctag agcccccgca accctcctcc tcgccctcgg tgctgtcctg     60

tggcccgccg ctggtgcttg ggaactgact atcctccaca ccaatgacgt gcattcacgg    120

ctggagcaga ccagcgaaga tagctccaaa tgcgtgaacg ctagccgctg tatgggcgga    180

gtcgcacgac tgttcacaaa ggtgcagcag atcaggagag ccgagcctaa tgtgctgctc    240

ctggacgctg gcgaccagta ccagggcaca atttggttca ctgtctataa gggagccgaa    300

gtggctcact ttatgaacgc actccgatac gacgcaatgg cactggggaa tcatgagttc    360

gataacggag tggaggggct gatcgaaccc ctcctgaagg aagccaaatt tcctatcctc    420

tccgcaaaca ttaaggccaa aggaccactg gctagtcaga tcagcgggct ctacctgccc    480

tataaagtcc tgcctgtggg cgacgaggtg gtcggtattg tgggctatac ctccaaggaa    540

acaccattcc tctctaatcc cggaaccaac ctggtgtttg aggacgaaat cacagccctg    600

cagcccgagg tcgataagct caaaaccctg aatgtgaaca agatcattgc tctcggacac    660

agtgggtttg aaatggacaa gctgattgca cagaaagtcc ggggagtgga tgtggtcgtg    720

gggggtcata gcaatacttt cctgtacacc ggaaaccccc cttccaagga ggtgcctgct    780

gggaaatatc ccttcatcgt cacatccgac gatgggagga aggtgcctgt cgtgcaggct    840

tacgccttcg gcaagtacct cggctatctg aaaatcgagt ttgacgaaag aggaaatgtg    900

atttctagtc acgggaatcc aatcctcctg aactcaagca ttccagagga cccctcaatc    960

aaagccgata ttaataagtg gaggatcaaa ctggacaact acagcacaca ggagctcggc   1020

aagactatcg tgtacctgga tggctcctct cagtcttgcc ggttccgcga atgtaatatg   1080

ggaaacctga tctgcgacgc aatgattaac aataacctga gacacgccga tgagaccttt   1140

tggaatcacg tgagcatgtg catcctgaac ggcggaggga tcagaagtcc aattgacgag   1200

cggaataacg ggaccattac atgggaaaac ctcgcagctg tcctgccctt cggtggcact   1260

tttgatctcg tgcagctgaa gggcagcacc ctgaagaaag ccttcgagca cagtgtgcat   1320

cgatacggac agtcaactgg ggaatttctg caagtgggag ggatccacgt cgtgtatgac   1380

ctgtcccgaa agcccggcga cagggtcgtg aaactcgatg tcctgtgcac aaagtgtcgc   1440

gtgccttctt acgacccact gaagatggat gaggtctata aagtgatcct ccctaatttc   1500

ctggcaaacg gtggcgatgg ttttcagatg atcaaggacg aactcctgcg gcacgattct   1560

ggcgaccagg atattaacgt cgtgtctaca tacatcagta agatgaaagt gatctaccca   1620

gctgtggagg gtcgcatcaa gttcagcact ggctcccatt gccacgggtc attttccctc   1680

attttcctct ccctgtgggc agtcattttt gtcctgtatc agtga                   1725


<210>  57
<211>  3320
<212>  DNA
<213>  artificial

<220>
<223>  CD39-2A-CD73 derived from homo sapiens, codon optimized

<400>  57
atggaggaca ccaaggagag caacgtgaag accttctgca gcaagaacat cctggccatc     60

ctgggcttca gcagcatcat cgccgtgatc gccctgctgg ccgtgggcct gacccagaac    120

aaggccctgc ccgagaacgt gaagtacggc atcgtgctgg acgccggcag cagccacacc    180

agcctgtaca tctacaagtg gcccgccgag aaggagaacg acaccggcgt ggtgcaccag    240

gtggaggagt gcagagtgaa gggccccggc atcagcaagt tcgtgcagaa ggtgaacgag    300

atcggcatct acctgaccga ctgcatggag agagccagag aggtgatccc cagaagccag    360

caccaggaga cccccgtgta cctgggcgcc accgccggca tgagactgct gagaatggag    420

agcgaggagc tggccgacag agtgctggac gtggtggaga gaagcctgag caactacccc    480

ttcgacttcc agggcgccag aatcatcacc ggccaggagg agggcgccta cggctggatc    540

accatcaact acctgctggg caagttcagc cagaagacca gatggttcag catcgtgccc    600

tacgagacca acaaccagga gaccttcggc gccctggacc tgggcggcgc cagcacccag    660

gtgaccttcg tgccccagaa ccagaccatc gagagccccg acaacgccct gcagttcaga    720

ctgtacggca aggactacaa cgtgtacacc cacagcttcc tgtgctacgg caaggaccag    780

gccctgtggc agaagctggc caaggacatc caggtggcca gcaacgagat cctgagagac    840

ccctgcttcc accccggcta caagaaggtg gtgaacgtga gcgacctgta caagaccccc    900

tgcaccaaga gattcgagat gaccctgccc ttccagcagt tcgagatcca gggcatcggc    960

aactaccagc agtgccacca gagcatcctg gagctgttca acaccagcta ctgcccctac   1020

agccagtgcg ccttcaacgg catcttcctg ccccccctgc agggcgactt cggcgccttc   1080

agcgccttct acttcgtgat gaagttcctg aacctgacca gcgagaaggt gagccaggag   1140

aaggtgaccg agatgatgaa gaagttctgc gcccagccct gggaggagat caagaccagc   1200

tacgccggcg tgaaggagaa gtacctgagc gagtactgct tcagcggcac ctacatcctg   1260

agcctgctgc tgcagggcta ccacttcacc gccgacagct gggagcacat ccacttcatc   1320

ggcaagatcc agggcagcga cgccggctgg accctgggct acatgctgaa cctgaccaac   1380

atgatccccg ccgagcagcc cctgagcacc cccctgagcc acagcaccta cgtgttcctg   1440

atggtgctgt tcagcctggt gctgttcacc gtggccatca tcggcctgct gatcttccac   1500

aagcccagct acttctggaa ggacatggtg ggcagcggcg ccaccaactt cagcctgctg   1560

aagcaggccg gcgacgtgga ggagaacccc ggccccatgt gccccagagc cgccagagcc   1620

cccgccaccc tgctgctggc cctgggcgcc gtgctgtggc ccgccgccgg cgcctgggag   1680

ctgaccatcc tgcacaccaa cgacgtgcac agcagactgg agcagaccag cgaggacagc   1740

agcaagtgcg tgaacgccag cagatgcatg ggcggcgtgg ccagactgtt caccaaggtg   1800

cagcagatca gaagagccga gcccaacgtg ctgctgctgg acgccggcga ccagtaccag   1860

ggcaccatct ggttcaccgt gtacaagggc gccgaggtgg cccacttcat gaacgccctg   1920

agatacgacg ccatggccct gggcaaccac gagttcgaca acggcgtgga gggcctgatc   1980

gagcccctgc tgaaggaggc caagttcccc atcctgagcg ccaacatcaa ggccaagggc   2040

cccctggcca gccagatcag cggcctgtac ctgccctaca aggtgctgcc cgtgggcgac   2100

gaggtggtgg gcatcgtggg ctacaccagc aaggagaccc ccttcctgag caaccccggc   2160

accaacctgg tgttcgagga cgagatcacc gccctgcagc ccgaggtgga caagctgaag   2220

accctgaacg tgaacaagat catcgccctg ggccacagcg gcttcgagat ggacaagctg   2280

atcgcccaga aggtgagagg cgtggacgtg gtggtgggcg gccacagcaa caccttcctg   2340

tacaccggca acccccccag caaggaggtg cccgccggca agtacccctt catcgtgacc   2400

gcgacgacgg cagaaaggtg cccgtggtgc aggcctacgc cttcggcaag tacctgggct   2460

acctgaagat cgagttcgac gagagaggca acgtgatcag cagccacggc aaccccatcc   2520

tgctgaacag cagcatcccc gaggacccca gcatcaaggc cgacatcaac aagtggagaa   2580

tcaagctgga caactacagc acccaggagc tgggcaagac catcgtgtac ctggacggca   2640

gcagccagag ctgcagattc agagagtgca acatgggcaa cctgatctgc gacgccatga   2700

tcaacaacaa cctgagacac gccgacgaga ccttctggaa ccacgtgagc atgtgcatcc   2760

tgaacggcgg cggcatcaga agccccatcg acgagagaaa caacggcacc atcacctggg   2820

agaacctggc cgccgtgctg cccttcggcg gcaccttcga cctggtgcag ctgaagggca   2880

gcaccctgaa gaaggccttc gagcacagcg tgcacagata cggccagagc accggcgagt   2940

tcctgcaggt gggcggcatc cacgtggtgt acgacctgag cagaaagccc ggcgacagag   3000

tggtgaagct ggacgtgctg tgcaccaagt gcagagtgcc cagctacgac cccctgaaga   3060

tggacgaggt gtacaaggtg atcctgccca acttcctggc caacggcggc gacggcttcc   3120

agatgatcaa ggacgagctg ctgagacacg acagcggcga ccaggacatc aacgtggtga   3180

gcacctacat cagcaagatg aaggtgatct accccgccgt ggagggcaga atcaagttca   3240

gcaccggcag ccactgccac ggcagcttca gcctgatctt cctgagcctg tgggccgtga   3300

tcttcgtgct gtaccagtag                                               3320


