                         SEQUENCE LISTING

<110>  PFIZER INC
       Gardner, Joseph Paul II
       Wong, Victoria Yatsum
 
<120>  ANTI-DRUG ANTIBODIES AND USES THEREOF FOR DRUG MONITORING

<130>  PC71701A

<140>  PCT/US2013/to be assigned
<141>  2013-06-17

<150>  US 61/665,361
<151>  2012-06-28

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asp Gly Tyr Thr Pro Tyr Tyr Ser Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Thr Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Pro His Tyr Tyr Gly Phe Pro Phe Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  2
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Asn 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Ser Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Met Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  3
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Thr Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Pro Tyr Gly Ser Ser Phe Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  4
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  4

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Thr Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Tyr Gly Ser Ser Phe Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Ala Val Ser Ser 
        115         


<210>  6
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Val Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Arg Asn Asn Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  7
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  7

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Arg Lys Asp Tyr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile Tyr Tyr Gly Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  8
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Val Gln Leu Gln Gly Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Thr Leu Glu Trp 
        35                  40                  45              


Met Gly Phe Ile His Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Pro Tyr Gly Ser Ser Phe Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  9
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Thr Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Leu Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  10
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Met Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Thr Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Asn Thr Val Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Pro Tyr Gly Ser Ser Phe Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  11
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  12
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ile Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Val Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile Tyr Tyr Gly Ile Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A3-E5-HCDR1

<400>  13

Gly Phe Thr Phe Asn Asp Tyr Tyr 
1               5               


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A3-E5-HCDR2

<400>  14

Ile Arg Asn Lys Ala Asp Gly Tyr Thr Pro 
1               5                   10  


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A3-E5-HCDR3

<400>  15

Ala Arg Pro His Tyr Tyr Gly Phe Pro Phe Gly Tyr 
1               5                   10          


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A3-E5-LCDR1

<400>  16

Thr Gly Ala Val Thr Thr Asn Asn Tyr 
1               5                   


<210>  17
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A3-E5-LCDR2

<400>  17

Gly Thr Asn 
1           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A3-E5-LCDR3

<400>  18

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A6-C5-HCDR1

<400>  19

Gly Tyr Ser Ile Thr Ser Gly Tyr Ser 
1               5                   


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A6-C5-HCDR2

<400>  20

Ile His Tyr Ser Gly Ser Thr 
1               5           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A6-C5-HCDR3

<400>  21

Val Arg Gly Pro Tyr Gly Ser Ser Phe Tyr 
1               5                   10  


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A6-C5-LCDR1

<400>  22

Glu Asn Val Val Thr Tyr 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A6-C5-LCDR2

<400>  23

Gly Ala Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A6-C5-LCDR3

<400>  24

Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10F10-H5-HCDR2

<400>  25

Ile His Tyr Ser Gly Thr Thr 
1               5           


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10F10-H5-HCDR3

<400>  26

Ala Arg Gly Pro Tyr Gly Ser Ser Phe Tyr 
1               5                   10  


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10F10-H5-LCDR1

<400>  27

Ser Ser Val Ser Ser 
1               5   


<210>  28
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10F10-H5-LCDR2

<400>  28

Ser Thr Ser 
1           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10F10-H5-LCDR3

<400>  29

Gln Gln Arg Asn Asn Tyr Pro Tyr Thr 
1               5                   


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D9-A5-HCDR1

<400>  30

Gly Phe Ser Leu Ser Arg Tyr Ser 
1               5               


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D9-A5-HCDR2

<400>  31

Ile Trp Gly Gly Gly Ser Thr 
1               5           


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D9-A5-HCDR3

<400>  32

Ala Arg Ile Tyr Tyr Gly Ile Tyr 
1               5               


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12H4-G2-LCDR1

<400>  33

Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F10-E6-LCDR1

<400>  34

Gln Asn Val Gly Thr Asn 
1               5       


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F10-E6-LCDR2

<400>  35

Ser Ala Ser 
1           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F10-E6-LCDR3

<400>  36

Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr 
1               5                   


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12D4-G6-HCDR1

<400>  37

Gly Phe Ser Leu Ser Ile Tyr Ser 
1               5               


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12D4-G6-HCDR2

<400>  38

Ile Trp Gly Gly Gly Asn Thr 
1               5           


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12D4-G6-HCDR3

<400>  39

Ala Arg Ile Tyr Tyr Gly Ile Phe 
1               5               


