                         SEQUENCE LISTING

<110>  Waclawczyk, Simon
       Buchheiser, Anja 
        
<120>  CELL OF HEPATOCYTE PHENOTYPE

<130>  CKI14436PCT-1

<150>  PCT/EP2012/061679
<151>  20012-06-19


<160>  78    

<170>  PatentIn version 3.3

<210>  1
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer GAPDH

<400>  1
gagtcaacgg atttggtcgt                                                 20


<210>  2
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer GAPDH

<400>  2
ttgattttgg agggatctcg                                                 20


<210>  3
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  forward primer GSC

<400>  3
atcaccagcc actgcttcc                                                  19


<210>  4
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer GSC

<400>  4
caggttgctg gctgtctcc                                                  19


<210>  5
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  forward primer MIXL1

<400>  5
aagcgcacgt ctttcagc                                                   18


<210>  6
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer MIXL1

<400>  6
ttcagagaga ggggaacagg                                                 20


<210>  7
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  forward primer BRY

<400>  7
atcaccagcc actgcttcc                                                  19


<210>  8
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer BRY

<400>  8
caggttgctg gctgtctcc                                                  19


<210>  9
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer GATA4

<400>  9
tccaaaccag aaaacggaag                                                 20


<210>  10
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer GATA4

<400>  10
tgcccgtagt gagatgacag                                                 20


<210>  11
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer CER1

<400>  11
tcatcttgcc catcaaaagc                                                 20


<210>  12
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer CER1

<400>  12
cacggaggaa agttcagtgc                                                 20


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer HEX

<400>  13
gcgagagaca ggtcaaaacc                                                 20


<210>  14
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer HEX

<400>  14
gagggcgaac attgagagc                                                  19


<210>  15
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer albumin

<400>  15
aaagccttgg tgttgattgc                                                 20


<210>  16
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer albumin

<400>  16
gtcagccatt tcaccatagg                                                 20


<210>  17
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward forward primer AFP

<400>  17
gtacggacat tcagactgct                                                 20


<210>  18
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer AFP

<400>  18
attgtaggtg catacaggaa g                                               21


<210>  19
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer FBP1

<400>  19
tgccgtcact gagtacatcc                                                 20


<210>  20
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer FBP1

<400>  20
gctaacaaga agagccccaa                                                 20


<210>  21
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer G6PC

<400>  21
tgcccctgat aaagcagttc                                                 20


<210>  22
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer G6PC

<400>  22
gaggaaaatg agcagcaagg                                                 20


<210>  23
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer ARG1

<400>  23
ggaaacttgc atggacaacc                                                 20


<210>  24
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer ARG1

<400>  24
ccatcacctt gccaattcc                                                  19


<210>  25
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer CPS1

<400>  25
cacatcagac tggctcaacg                                                 20


<210>  26
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer CPS1

<400>  26
gagggattcc actatcaaca gc                                              22


<210>  27
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  forward primer CYP3A4

<400>  27
acaccctttg gaagtggac                                                  19


<210>  28
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer CYP3A4

<400>  28
tgactcaacc tttagaacaa cg                                              22


<210>  29
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer PROX1

<400>  29
atgcaggaag gattgtcacc                                                 20


<210>  30
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer PROX1

<400>  30
ccacttgatg agctgagagg                                                 20


<210>  31
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer HNF1 alpha

<400>  31
cagagccatg tgacccagag                                                 20


<210>  32
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer HNF1 alpha

<400>  32
tgaggtgaag acctgcttgg
 

<210>  33
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  forward primer FOXA2

<400>  33
gagcggtgaa gatggaagg                                                  19


<210>  34
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer FOXA2

<400>  34
gctcatggag ttcatgttgg                                                 20


<210>  35
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer HNF4 alpha

<400>  35
tactcctgca gatttagccg                                                 20


<210>  36
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer HNF4 alpha

<400>  36
gtcattgcct aggagcagc                                                  19


<210>  37
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  forward primer HNF6

<400>  37
agaccttccg gaggatgtg                                                  19


<210>  38
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer HNF6

<400>  38
tggatggacg cttattttcc                                                 20


<210>  39
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer C/EBP alpha

<400>  39
gaatcacacc agaaagctag                                                 20


<210>  40
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer C/EBP alpha

<400>  40
gatggactga tcgtgcttc                                                  19


<210>  41
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer C/EBP beta

<400>  41
tttcgaagtt gatgcaatcg                                                 20


<210>  42
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer C/EBP beta

<400>  42
acagcaacaa gcccgtagg                                                  19


<210>  43
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  forward primer GATA6

<400>  43
ggcttggatt gtcctgtgc                                                  19


<210>  44
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer GATA6

<400>  44
agttggagtc atgggaatgg                                                 20


<210>  45
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  forward primer HNF1 beta

<400>  45
gcaatggtgg tcacagatac c                                               21


<210>  46
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer HNF1 beta

<400>  46
gtgatggtgt ggaaaacagg                                                 20


<210>  47
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer SOX17

<400>  47
cagaatccag acctgcacaa                                                 20


<210>  48
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer SOX17

<400>  48
gcggccggta cttgtagtt                                                  19


<210>  49
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer LRH-1

<400>  49
atcctcgacc acatttaccg                                                 20


<210>  50
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer LRH-1

<400>  50
tttgccacta actcctgtgc                                                 20


<210>  51
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer PXR

<400>  51
acttctactg gagcccatgc                                                 20


<210>  52
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  reverse primre PXR

<400>  52
ttcaggaaca agaacctatg agc                                             23


<210>  53
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  forward primer FXR

<400>  53
ttgacggaaa tggcaacc                                                   18


<210>  54
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer FXR

<400>  54
taggtcagaa tgcccagacg                                                 20


<210>  55
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer BSEP

<400>  55
tcccaggggt ctcaactctc                                                 20


<210>  56
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer BSEP

<400>  56
aacctgcacc gtcttttcac                                                 20


<210>  57
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  forward primer GYS2

<400>  57
gttatactcc agctgaatgc a                                               21


<210>  58
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer GYS2

<400>  58
catgctggta atatctgcct a                                               21


<210>  59
<211>  465
<212>  PRT
<213>  human

<400>  59

Met Asn Ala Gln Leu Thr Met Glu Ala Ile Gly Glu Leu His Gly Val 
1               5                   10                  15      


Ser His Glu Pro Val Pro Ala Pro Ala Asp Leu Leu Gly Gly Ser Pro 
            20                  25                  30          


His Ala Arg Ser Ser Val Ala His Arg Gly Ser His Leu Pro Pro Ala 
        35                  40                  45              


His Pro Arg Ser Met Gly Met Ala Ser Leu Leu Asp Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Asp Tyr His His His His Arg Ala Pro Glu His Ser Leu Ala 
65                  70                  75                  80  


Gly Pro Leu His Pro Thr Met Thr Met Ala Cys Glu Thr Pro Pro Gly 
                85                  90                  95      


Met Ser Met Pro Thr Thr Tyr Thr Thr Leu Thr Pro Leu Gln Pro Leu 
            100                 105                 110         


Pro Pro Ile Ser Thr Val Ser Asp Lys Phe Pro His His His His His 
        115                 120                 125             


His His His His His His Pro His His His Gln Arg Leu Ala Gly Asn 
    130                 135                 140                 


Val Ser Gly Ser Phe Thr Leu Met Arg Asp Glu Arg Gly Leu Ala Ser 
145                 150                 155                 160 


Met Asn Asn Leu Tyr Thr Pro Tyr His Lys Asp Val Ala Gly Met Gly 
                165                 170                 175     


Gln Ser Leu Ser Pro Leu Ser Ser Ser Gly Leu Gly Ser Ile His Asn 
            180                 185                 190         


Ser Gln Gln Gly Leu Pro His Tyr Ala His Pro Gly Ala Ala Met Pro 
        195                 200                 205             


Thr Asp Lys Met Leu Thr Pro Asn Gly Phe Glu Ala His His Pro Ala 
    210                 215                 220                 


Met Leu Gly Arg His Gly Glu Gln His Leu Thr Pro Thr Ser Ala Gly 
225                 230                 235                 240 


Met Val Pro Ile Asn Gly Leu Pro Pro His His Pro His Ala His Leu 
                245                 250                 255     


Asn Ala Gln Gly His Gly Gln Leu Leu Gly Thr Ala Arg Glu Pro Asn 
            260                 265                 270         


Pro Ser Val Thr Gly Ala Gln Val Ser Asn Gly Ser Asn Ser Gly Gln 
        275                 280                 285             


Met Glu Glu Ile Asn Thr Lys Glu Val Ala Gln Arg Ile Thr Thr Glu 
    290                 295                 300                 


Leu Lys Arg Tyr Ser Ile Pro Gln Ala Ile Phe Ala Gln Arg Val Leu 
305                 310                 315                 320 


Cys Arg Ser Gln Gly Thr Leu Ser Asp Leu Leu Arg Asn Pro Lys Pro 
                325                 330                 335     


Trp Ser Lys Leu Lys Ser Gly Arg Glu Thr Phe Arg Arg Met Trp Lys 
            340                 345                 350         


Trp Leu Gln Glu Pro Glu Phe Gln Arg Met Ser Ala Leu Arg Leu Ala 
        355                 360                 365             


Ala Cys Lys Arg Lys Glu Gln Glu His Gly Lys Asp Arg Gly Asn Thr 
    370                 375                 380                 


Pro Lys Lys Pro Arg Leu Val Phe Thr Asp Val Gln Arg Arg Thr Leu 
385                 390                 395                 400 


His Ala Ile Phe Lys Glu Asn Lys Arg Pro Ser Lys Glu Leu Gln Ile 
                405                 410                 415     


Thr Ile Ser Gln Gln Leu Gly Leu Glu Leu Ser Thr Val Ser Asn Phe 
            420                 425                 430         


Phe Met Asn Ala Arg Arg Arg Ser Leu Asp Lys Trp Gln Asp Glu Gly 
        435                 440                 445             


Ser Ser Asn Ser Gly Asn Ser Ser Ser Ser Ser Ser Thr Cys Thr Lys 
    450                 455                 460                 


Ala 
465 


<210>  60
<211>  469
<212>  PRT
<213>  mouse

<400>  60

Met Asn Ala Gln Leu Thr Met Glu Ala Ile Gly Glu Leu His Gly Val 
1               5                   10                  15      


Ser His Glu Pro Val Pro Ala Pro Ala Asp Leu Leu Gly Gly Ser Pro 
            20                  25                  30          


His Ala Arg Ser Ser Val Gly His Arg Gly Ser His Leu Pro Pro Ala 
        35                  40                  45              


His Pro Arg Ser Met Gly Met Ala Ser Leu Leu Asp Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Asp Tyr His His His His Arg Ala Pro Glu His Ser Leu Ala 
65                  70                  75                  80  


Gly Pro Leu His Pro Thr Met Thr Met Ala Cys Glu Thr Pro Pro Gly 
                85                  90                  95      


Met Ser Met Pro Thr Thr Tyr Thr Thr Leu Thr Pro Leu Gln Pro Leu 
            100                 105                 110         


Pro Pro Ile Ser Thr Val Ser Asp Lys Phe Pro His His His His His 
        115                 120                 125             


His His His His His His Pro His His His Gln Arg Leu Ala Gly Asn 
    130                 135                 140                 


Val Ser Gly Ser Phe Thr Leu Met Arg Asp Glu Arg Gly Leu Ala Ser 
145                 150                 155                 160 


Met Asn Asn Leu Tyr Thr Pro Tyr His Lys Asp Val Ala Gly Met Gly 
                165                 170                 175     


Gln Ser Leu Ser Pro Leu Ser Gly Ser Gly Leu Gly Ser Ile His Asn 
            180                 185                 190         


Ser Gln Gln Gly Leu Pro His Tyr Ala His Pro Gly Ala Ala Met Pro 
        195                 200                 205             


Thr Asp Lys Met Leu Thr Pro Asn Gly Phe Glu Ala His His Pro Ala 
    210                 215                 220                 


Met Leu Gly Arg His Gly Glu Gln His Leu Thr Pro Thr Ser Ala Gly 
225                 230                 235                 240 


Met Val Pro Ile Asn Gly Leu Pro Pro His His Pro His Ala His Leu 
                245                 250                 255     


Asn Ala Gln Gly His Gly Gln Leu Leu Gly Thr Ala Arg Glu Pro Asn 
            260                 265                 270         


Pro Ser Val Thr Gly Ala Gln Val Ser Asn Gly Ser Asn Ser Gly Gln 
        275                 280                 285             


Met Glu Glu Ile Asn Thr Lys Glu Val Ala Gln Arg Ile Thr Thr Glu 
    290                 295                 300                 


Leu Lys Arg Tyr Ser Ile Pro Gln Ala Ile Phe Ala Gln Arg Val Leu 
305                 310                 315                 320 


Cys Arg Ser Gln Gly Thr Leu Ser Asp Leu Leu Arg Asn Pro Lys Pro 
                325                 330                 335     


Trp Ser Lys Leu Lys Ser Gly Arg Glu Thr Phe Arg Arg Met Trp Lys 
            340                 345                 350         


Trp Leu Gln Glu Pro Glu Phe Gln Arg Met Ser Ala Leu Arg Leu Ala 
        355                 360                 365             


Ala Cys Lys Arg Lys Glu Gln Glu His Gly Lys Asp Arg Gly Asn Thr 
    370                 375                 380                 


Pro Lys Lys Pro Arg Leu Val Phe Thr Asp Val Gln Arg Arg Thr Leu 
385                 390                 395                 400 


His Ala Ile Phe Lys Glu Asn Lys Arg Pro Ser Lys Glu Leu Gln Ile 
                405                 410                 415     


Thr Ile Ser Gln Gln Leu Gly Leu Glu Leu Ser Thr Val Ser Asn Phe 
            420                 425                 430         


Phe Met Asn Ala Arg Arg Arg Ser Leu Asp Lys Trp Gln Asp Glu Gly 
        435                 440                 445             


Gly Ser Asn Ser Gly Ser Ser Ser Ser Ser Ser Ser Thr Cys Thr Lys 
    450                 455                 460                 


Ala His Ile Asp Glu 
465                 


<210>  61
<211>  465
<212>  PRT
<213>  rat

<400>  61

Met Asn Ala Gln Leu Thr Met Glu Ala Ile Gly Glu Leu His Gly Val 
1               5                   10                  15      


Ser His Glu Pro Val Pro Ala Pro Ala Asp Leu Leu Gly Gly Ser Pro 
            20                  25                  30          


His Ala Arg Ser Ser Val Gly His Arg Gly Ser His Leu Pro Pro Ala 
        35                  40                  45              


His Pro Arg Ser Met Gly Met Ala Ser Leu Leu Asp Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Asp Tyr His His His His Arg Ala Pro Glu His Ser Leu Ala 
65                  70                  75                  80  


Gly Pro Leu His Pro Thr Met Thr Met Ala Cys Glu Thr Pro Pro Gly 
                85                  90                  95      


Met Ser Met Pro Thr Thr Tyr Thr Thr Leu Thr Pro Leu Gln Pro Leu 
            100                 105                 110         


Pro Pro Ile Ser Thr Val Ser Asp Lys Phe Pro His His His His His 
        115                 120                 125             


His His His His His His Pro His His His Gln Arg Leu Ala Gly Asn 
    130                 135                 140                 


Val Ser Gly Ser Phe Thr Leu Met Arg Asp Glu Arg Gly Leu Ala Ser 
145                 150                 155                 160 


Met Asn Asn Leu Tyr Thr Pro Tyr His Lys Asp Val Ala Gly Met Gly 
                165                 170                 175     


Gln Ser Leu Ser Pro Leu Ser Gly Ser Gly Leu Gly Ser Ile His Asn 
            180                 185                 190         


Ser Gln Gln Gly Leu Pro His Tyr Ala His Pro Gly Ala Ala Met Pro 
        195                 200                 205             


Thr Asp Lys Met Leu Thr Pro Asn Asp Phe Glu Ala His His Pro Ala 
    210                 215                 220                 


Met Leu Gly Arg His Gly Glu Gln His Leu Thr Pro Thr Ser Ala Gly 
225                 230                 235                 240 


Met Val Pro Ile Asn Gly Leu Pro Pro His His Pro His Ala His Leu 
                245                 250                 255     


Asn Ala Gln Gly His Gly Gln Leu Leu Gly Thr Ala Arg Glu Pro Asn 
            260                 265                 270         


Pro Ser Val Thr Gly Ala Gln Val Ser Asn Gly Ser Asn Ser Gly Gln 
        275                 280                 285             


Met Glu Glu Ile Asn Thr Lys Glu Val Ala Gln Arg Ile Thr Thr Glu 
    290                 295                 300                 


Leu Lys Arg Tyr Ser Ile Pro Gln Ala Ile Phe Ala Gln Arg Val Leu 
305                 310                 315                 320 


Cys Arg Ser Gln Gly Thr Leu Ser Asp Leu Leu Arg Asn Pro Lys Pro 
                325                 330                 335     


Trp Ser Lys Leu Lys Ser Gly Arg Glu Thr Phe Arg Arg Met Trp Lys 
            340                 345                 350         


Trp Leu Gln Glu Pro Glu Phe Gln Arg Met Ser Ala Leu Arg Leu Ala 
        355                 360                 365             


Ala Cys Lys Arg Lys Glu Gln Glu His Gly Lys Asp Arg Gly Asn Thr 
    370                 375                 380                 


Pro Lys Lys Pro Arg Leu Val Phe Thr Asp Val Gln Arg Arg Thr Leu 
385                 390                 395                 400 


His Ala Ile Phe Lys Glu Asn Lys Arg Pro Ser Lys Glu Leu Gln Ile 
                405                 410                 415     


Thr Ile Ser Gln Gln Leu Gly Leu Glu Leu Ser Thr Val Ser Asn Phe 
            420                 425                 430         


Phe Met Asn Ala Arg Arg Arg Ser Leu Asp Lys Trp Gln Asp Glu Gly 
        435                 440                 445             


Ser Ser Asn Ser Gly Asn Ser Ser Ser Ser Ser Ser Thr Cys Thr Lys 
    450                 455                 460                 


Ala 
465 


<210>  62
<211>  90
<212>  PRT
<213>  Bos taurus

<400>  62

Leu Gln Glu Pro Glu Phe Gln Arg Met Ser Ala Leu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Lys Arg Lys Glu Gln Glu His Gly Lys Asp Arg Gly Ser Thr Pro 
            20                  25                  30          


Lys Lys Pro Arg Leu Val Phe Thr Asp Val Gln Arg Arg Thr Leu His 
        35                  40                  45              


Ala Ile Phe Lys Glu Asn Lys Arg Pro Ser Lys Glu Leu Gln Ile Thr 
    50                  55                  60                  


Ile Ser Gln Gln Leu Gly Leu Glu Leu Ser Thr Val Ser Asn Phe Phe 
65                  70                  75                  80  


Met Asn Ala Arg Arg Arg Ser Leu Asp Lys 
                85                  90  


<210>  63
<211>  435
<212>  PRT
<213>  Macaca mulatta 

<400>  63

Ser Pro His Ala Arg Ser Ser Val Ala His Arg Gly Ser His Leu Pro 
1               5                   10                  15      


Pro Ala His Pro Arg Ser Met Gly Met Ala Ser Leu Leu Asp Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Asp Tyr His His His His Arg Ala Pro Glu His Ser 
        35                  40                  45              


Leu Ala Gly Pro Leu His Pro Thr Met Thr Met Ala Cys Glu Thr Pro 
    50                  55                  60                  


Pro Gly Met Ser Met Pro Thr Thr Tyr Thr Thr Leu Thr Pro Leu Gln 
65                  70                  75                  80  


Pro Leu Pro Pro Ile Ser Thr Val Ser Asp Lys Phe Pro His His His 
                85                  90                  95      


His His His His His His His His Pro His His His Gln Arg Leu Ala 
            100                 105                 110         


Gly Asn Val Ser Gly Ser Phe Thr Leu Met Arg Asp Glu Arg Gly Leu 
        115                 120                 125             


Ala Ser Met Asn Asn Leu Tyr Thr Pro Tyr His Lys Asp Val Ala Gly 
    130                 135                 140                 


Met Gly Gln Ser Leu Ser Pro Leu Ser Ser Ser Gly Leu Gly Ser Ile 
145                 150                 155                 160 


His Asn Ser Gln Gln Gly Leu Pro His Tyr Ala His Pro Gly Ala Ala 
                165                 170                 175     


Met Pro Thr Asp Lys Met Leu Thr Pro Asn Gly Phe Glu Ala His His 
            180                 185                 190         


Pro Ala Met Leu Gly Arg His Gly Glu Gln His Leu Thr Pro Thr Ser 
        195                 200                 205             


Ala Gly Met Val Pro Ile Asn Gly Leu Pro Pro His His Pro His Ala 
    210                 215                 220                 


His Leu Asn Thr Gln Gly His Gly Gln Leu Leu Gly Thr Ala Arg Glu 
225                 230                 235                 240 


Pro Asn Pro Ser Val Thr Gly Ala Gln Val Ser Asn Gly Ser Asn Ser 
                245                 250                 255     


Gly Gln Met Glu Glu Ile Asn Thr Lys Glu Val Ala Gln Arg Ile Thr 
            260                 265                 270         


Thr Glu Leu Lys Arg Tyr Ser Ile Pro Gln Ala Ile Phe Ala Gln Arg 
        275                 280                 285             


Val Leu Cys Arg Ser Gln Gly Thr Leu Ser Asp Leu Leu Arg Asn Pro 
    290                 295                 300                 


Lys Pro Trp Ser Lys Leu Lys Ser Gly Arg Glu Thr Phe Arg Arg Met 
305                 310                 315                 320 


Trp Lys Trp Leu Gln Glu Pro Glu Phe Gln Arg Met Ser Ala Leu Arg 
                325                 330                 335     


Leu Ala Ala Cys Lys Arg Lys Glu Gln Glu His Gly Lys Asp Arg Gly 
            340                 345                 350         


Asn Thr Pro Lys Lys Pro Arg Leu Val Phe Thr Asp Val Gln Arg Arg 
        355                 360                 365             


Thr Leu His Ala Ile Phe Lys Glu Asn Lys Arg Pro Ser Lys Glu Leu 
    370                 375                 380                 


Gln Ile Thr Ile Ser Gln Gln Leu Gly Leu Glu Leu Ser Thr Val Ser 
385                 390                 395                 400 


Asn Phe Phe Met Asn Ala Arg Arg Arg Ser Leu Asp Lys Trp Gln Asp 
                405                 410                 415     


Glu Gly Ser Ser Asn Ser Gly Asn Ser Ser Ser Ser Ser Ser Thr Cys 
            420                 425                 430         


Thr Lys Ala 
        435 


<210>  64
<211>  311
<212>  PRT
<213>  Macaca fascicularis 

<400>  64

Glu Arg Gly Leu Ala Ser Met Asn Asn Leu Tyr Thr Pro Tyr His Lys 
1               5                   10                  15      


Asp Val Ala Gly Met Gly Gln Ser Leu Ser Pro Leu Ser Ser Ser Gly 
            20                  25                  30          


Leu Gly Ser Ile His Asn Ser Gln Gln Gly Leu Pro His Tyr Ala His 
        35                  40                  45              


Pro Gly Ala Ala Met Pro Thr Asp Lys Met Leu Thr Pro Asn Gly Phe 
    50                  55                  60                  


Glu Ala His His Pro Ala Met Leu Gly Arg His Gly Glu Gln His Leu 
65                  70                  75                  80  


Thr Pro Thr Ser Ala Gly Met Val Pro Ile Asn Gly Leu Pro Pro His 
                85                  90                  95      


His Pro His Ala His Leu Asn Thr Gln Gly His Gly Gln Leu Leu Ser 
            100                 105                 110         


Thr Ala Arg Glu Pro Asn Pro Ser Val Thr Gly Ala Gln Val Ser Asn 
        115                 120                 125             


Gly Ser Asn Ser Gly Gln Met Glu Glu Ile Asn Thr Lys Glu Val Ala 
    130                 135                 140                 


Gln Arg Ile Thr Thr Glu Leu Lys Arg Tyr Ser Ile Pro Gln Ala Ile 
145                 150                 155                 160 


Phe Ala Gln Arg Val Leu Cys Arg Ser Gln Gly Thr Leu Ser Asp Leu 
                165                 170                 175     


Leu Arg Asn Pro Lys Pro Trp Ser Lys Leu Lys Ser Gly Arg Glu Thr 
            180                 185                 190         


Phe Arg Arg Met Trp Lys Trp Leu Gln Glu Pro Glu Phe Gln Arg Met 
        195                 200                 205             


Ser Ala Leu Arg Leu Ala Ala Cys Lys Arg Lys Glu Gln Glu His Gly 
    210                 215                 220                 


Lys Asp Arg Gly Asn Thr Pro Lys Lys Pro Arg Leu Val Phe Thr Asp 
225                 230                 235                 240 


Val Gln Arg Arg Thr Leu His Ala Ile Phe Lys Glu Asn Lys Arg Pro 
                245                 250                 255     


Ser Lys Glu Leu Gln Ile Thr Ile Ser Gln Gln Leu Gly Leu Glu Leu 
            260                 265                 270         


Ser Thr Val Ser Asn Phe Phe Met Asn Ala Arg Arg Arg Ser Leu Asp 
        275                 280                 285             


Lys Trp Gln Asp Glu Gly Ser Ser Asn Ser Gly Asn Ser Ser Ser Ser 
    290                 295                 300                 


Ser Ser Thr Cys Thr Lys Ala 
305                 310     


<210>  65
<211>  631
<212>  PRT
<213>  human

<400>  65

Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu 
            20                  25                  30          


Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu 
        35                  40                  45              


Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu 
    50                  55                  60                  


Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp 
65                  70                  75                  80  


Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu 
                85                  90                  95      


Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro 
            100                 105                 110         


Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile 
        115                 120                 125             


Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu 
    130                 135                 140                 


Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala 
145                 150                 155                 160 


Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln 
                165                 170                 175     


Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp 
            180                 185                 190         


Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro 
        195                 200                 205             


Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro 
    210                 215                 220                 


Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu 
225                 230                 235                 240 


Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser 
                245                 250                 255     


Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg 
            260                 265                 270         


Lys Glu Glu Ala Phe Arg His Lys Leu Ala Met Asp Thr Tyr Ser Gly 
        275                 280                 285             


Pro Pro Pro Gly Pro Gly Pro Gly Pro Ala Leu Pro Ala His Ser Ser 
    290                 295                 300                 


Pro Gly Leu Pro Pro Pro Ala Leu Ser Pro Ser Lys Val His Gly Val 
305                 310                 315                 320 


Arg Tyr Gly Gln Pro Ala Thr Ser Glu Thr Ala Glu Val Pro Ser Ser 
                325                 330                 335     


Ser Gly Gly Pro Leu Val Thr Val Ser Thr Pro Leu His Gln Val Ser 
            340                 345                 350         


Pro Thr Gly Leu Glu Pro Ser His Ser Leu Leu Ser Thr Glu Ala Lys 
        355                 360                 365             


Leu Val Ser Ala Ala Gly Gly Pro Leu Pro Pro Val Ser Thr Leu Thr 
    370                 375                 380                 


Ala Leu His Ser Leu Glu Gln Thr Ser Pro Gly Leu Asn Gln Gln Pro 
385                 390                 395                 400 


Gln Asn Leu Ile Met Ala Ser Leu Pro Gly Val Met Thr Ile Gly Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Leu Gly Pro Thr Phe Thr Asn Thr Gly Ala Ser 
            420                 425                 430         


Thr Leu Val Ile Gly Leu Ala Ser Thr Gln Ala Gln Ser Val Pro Val 
        435                 440                 445             


Ile Asn Ser Met Gly Ser Ser Leu Thr Thr Leu Gln Pro Val Gln Phe 
    450                 455                 460                 


Ser Gln Pro Leu His Pro Ser Tyr Gln Gln Pro Leu Met Pro Pro Val 
465                 470                 475                 480 


Gln Ser His Val Thr Gln Ser Pro Phe Met Ala Thr Met Ala Gln Leu 
                485                 490                 495     


Gln Ser Pro His Ala Leu Tyr Ser His Lys Pro Glu Val Ala Gln Tyr 
            500                 505                 510         


Thr His Thr Gly Leu Leu Pro Gln Thr Met Leu Ile Thr Asp Thr Thr 
        515                 520                 525             


Asn Leu Ser Ala Leu Ala Ser Leu Thr Pro Thr Lys Gln Val Phe Thr 
    530                 535                 540                 


Ser Asp Thr Glu Ala Ser Ser Glu Ser Gly Leu His Thr Pro Ala Ser 
545                 550                 555                 560 


Gln Ala Thr Thr Leu His Val Pro Ser Gln Asp Pro Ala Gly Ile Gln 
                565                 570                 575     


His Leu Gln Pro Ala His Arg Leu Ser Ala Ser Pro Thr Val Ser Ser 
            580                 585                 590         


Ser Ser Leu Val Leu Tyr Gln Ser Ser Asp Ser Ser Asn Gly Gln Ser 
        595                 600                 605             


His Leu Leu Pro Ser Asn His Ser Val Ile Glu Thr Phe Ile Ser Thr 
    610                 615                 620                 


Gln Met Ala Ser Ser Ser Gln 
625                 630     


<210>  66
<211>  628
<212>  PRT
<213>  Mus musculus 

<400>  66

Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu 
            20                  25                  30          


Pro Gly Pro Tyr Leu Met Val Gly Glu Gly Pro Leu Asp Lys Gly Glu 
        35                  40                  45              


Ser Cys Gly Gly Ser Arg Gly Asp Leu Thr Glu Leu Pro Asn Gly Leu 
    50                  55                  60                  


Gly Glu Thr Arg Gly Ser Glu Asp Asp Thr Asp Asp Asp Gly Glu Asp 
65                  70                  75                  80  


Phe Ala Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu 
                85                  90                  95      


Ala Ala His Gln Lys Ala Val Val Glu Ser Leu Leu Gln Glu Asp Pro 
            100                 105                 110         


Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile 
        115                 120                 125             


Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu 
    130                 135                 140                 


Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala 
145                 150                 155                 160 


Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln 
                165                 170                 175     


Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp 
            180                 185                 190         


Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro 
        195                 200                 205             


Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro 
    210                 215                 220                 


Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu 
225                 230                 235                 240 


Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser 
                245                 250                 255     


Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg 
            260                 265                 270         


Lys Glu Glu Ala Phe Arg His Lys Leu Ala Met Asp Thr Tyr Asn Gly 
        275                 280                 285             


Pro Pro Pro Gly Pro Gly Pro Gly Pro Ala Leu Pro Ala His Ser Ser 
    290                 295                 300                 


Pro Gly Leu Pro Thr Thr Thr Leu Ser Pro Ser Lys Val His Gly Val 
305                 310                 315                 320 


Arg Tyr Gly Gln Ser Ala Thr Ser Glu Ala Ala Glu Val Pro Ser Ser 
                325                 330                 335     


Ser Gly Gly Pro Leu Val Thr Val Ser Ala Ala Leu His Gln Val Ser 
            340                 345                 350         


Pro Thr Gly Leu Glu Pro Ser Ser Leu Leu Ser Thr Glu Ala Lys Leu 
        355                 360                 365             


Val Ser Ala Thr Gly Gly Pro Leu Pro Pro Val Ser Thr Leu Thr Ala 
    370                 375                 380                 


Leu His Ser Leu Glu Gln Thr Ser Pro Gly Leu Asn Gln Gln Pro Gln 
385                 390                 395                 400 


Asn Leu Ile Met Ala Ser Leu Pro Gly Val Met Thr Ile Gly Pro Gly 
                405                 410                 415     


Glu Pro Ala Ser Leu Gly Pro Thr Phe Thr Asn Thr Gly Ala Ser Thr 
            420                 425                 430         


Leu Val Ile Gly Leu Ala Ser Thr Gln Ala Gln Ser Val Pro Val Ile 
        435                 440                 445             


Asn Ser Met Gly Ser Ser Leu Thr Thr Leu Gln Pro Val Gln Phe Ser 
    450                 455                 460                 


Gln Pro Leu His Pro Ser Tyr Gln Gln Pro Leu Met Pro Pro Val Gln 
465                 470                 475                 480 


Ser His Val Ala Gln Ser Pro Phe Met Ala Thr Met Ala Gln Leu Gln 
                485                 490                 495     


Ser Pro His Ala Leu Tyr Ser His Lys Pro Glu Val Ala Gln Tyr Thr 
            500                 505                 510         


His Thr Ser Leu Leu Pro Gln Thr Met Leu Ile Thr Asp Thr Asn Leu 
        515                 520                 525             


Ser Thr Leu Ala Ser Leu Thr Pro Thr Lys Gln Val Phe Thr Ser Asp 
    530                 535                 540                 


Thr Glu Ala Ser Ser Glu Pro Gly Leu His Glu Pro Pro Ser Pro Ala 
545                 550                 555                 560 


Thr Thr Ile His Ile Pro Ser Gln Asp Pro Ser Asn Ile Gln His Leu 
                565                 570                 575     


Gln Pro Ala His Arg Leu Ser Thr Ser Pro Thr Val Ser Ser Ser Ser 
            580                 585                 590         


Leu Val Leu Tyr Gln Ser Ser Asp Ser Asn Gly His Ser His Leu Leu 
        595                 600                 605             


Pro Ser Asn His Ser Val Ile Glu Thr Phe Ile Ser Thr Gln Met Ala 
    610                 615                 620                 


Ser Ser Ser Gln 
625             


<210>  67
<211>  632
<212>  PRT
<213>  Rattus norvegicus 

<400>  67

Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu 
            20                  25                  30          


Pro Gly Pro Tyr Leu Met Val Gly Asp Gly Pro Leu Asp Lys Gly Glu 
        35                  40                  45              


Ser Cys Gly Gly Thr Arg Gly Asp Leu Thr Glu Leu Pro Asn Gly Leu 
    50                  55                  60                  


Gly Glu Thr Arg Gly Ser Glu Asp Asp Thr Asp Asp Asp Gly Glu Asp 
65                  70                  75                  80  


Phe Ala Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu 
                85                  90                  95      


Ala Ala His Gln Lys Ala Val Val Glu Ser Leu Leu Gln Glu Asp Pro 
            100                 105                 110         


Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile 
        115                 120                 125             


Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu 
    130                 135                 140                 


Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala 
145                 150                 155                 160 


Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln 
                165                 170                 175     


Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp 
            180                 185                 190         


Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro 
        195                 200                 205             


Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro 
    210                 215                 220                 


Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu 
225                 230                 235                 240 


Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser 
                245                 250                 255     


Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg 
            260                 265                 270         


Lys Glu Glu Ala Phe Arg His Lys Leu Ala Met Asp Thr Tyr Asn Gly 
        275                 280                 285             


Pro Pro Pro Gly Pro Gly Pro Gly Pro Ala Leu Pro Ala His Ser Ser 
    290                 295                 300                 


Pro Gly Leu Pro Thr Thr Thr Leu Ser Pro Ser Lys Val His Gly Val 
305                 310                 315                 320 


Arg Tyr Gly Gln Ser Ala Thr Ser Glu Ala Ala Glu Val Pro Ser Ser 
                325                 330                 335     


Ser Gly Gly Pro Leu Val Thr Val Ser Ala Ala Leu His Gln Val Ser 
            340                 345                 350         


Pro Thr Gly Leu Glu Pro Ser Ser Leu Leu Ser Thr Glu Ala Lys Leu 
        355                 360                 365             


Val Ser Ala Thr Gly Gly Pro Leu Pro Pro Val Ser Thr Leu Thr Ala 
    370                 375                 380                 


Leu His Ser Leu Glu Gln Thr Ser Pro Gly Leu Asn Gln Gln Pro Gln 
385                 390                 395                 400 


Asn Leu Ile Met Ala Ser Leu Pro Gly Val Met Thr Ile Gly Pro Gly 
                405                 410                 415     


Glu Pro Ala Ser Leu Gly Pro Thr Phe Thr Asn Thr Gly Ala Ser Thr 
            420                 425                 430         


Leu Val Ile Gly Leu Ala Ser Thr Gln Ala Gln Ser Val Pro Val Ile 
        435                 440                 445             


Asn Ser Met Gly Ser Ser Leu Thr Thr Leu Gln Pro Val Gln Phe Ser 
    450                 455                 460                 


Gln Pro Leu His Pro Ser Tyr Gln Gln Pro Leu Met Pro Pro Val Gln 
465                 470                 475                 480 


Ser His Val Ala Gln Ser Pro Phe Met Ala Thr Met Ala Gln Leu Gln 
                485                 490                 495     


Ser Pro His Ala Leu Tyr Ser His Lys Pro Glu Val Ala Gln Tyr Thr 
            500                 505                 510         


His Thr Ser Leu Leu Pro Gln Thr Met Leu Ile Thr Asp Thr Asn Leu 
        515                 520                 525             


Ser Thr Leu Ala Ser Leu Thr Pro Thr Lys Gln Val Phe Thr Ser Asp 
    530                 535                 540                 


Thr Glu Ala Ser Ser Glu Pro Gly Leu His Glu Pro Ser Ser Pro Ala 
545                 550                 555                 560 


Thr Thr Ile His Ile Pro Ser Gln Asp Pro Ser Asn Ile Gln His Leu 
                565                 570                 575     


Gln Pro Ala His Arg Leu Ser Thr Ser Pro Thr Val Ser Ser Ser Ser 
            580                 585                 590         


Leu Val Leu Tyr Gln Ser Ser Asp Ser Asn Gly His Ser His Leu Leu 
        595                 600                 605             


Pro Ser Asn His Gly Val Ile Glu Thr Phe Ile Ser Thr Gln Met Ala 
    610                 615                 620                 


Ser Ser Ser Gln His Ile Asp Glu 
625                 630         


<210>  68
<211>  634
<212>  PRT
<213>  Gallus gallus 

<400>  68

Met Val Ser Lys Leu Ser His Leu Gln Val Glu Leu Leu Gly Ala Leu 
1               5                   10                  15      


Leu Glu Ser Gly Leu Thr Lys Glu Thr Leu Ile Lys Gly Leu Ser Glu 
            20                  25                  30          


Ala Glu Pro Tyr Val Leu Gln Ser Glu Ser Gln His Ala Ile Asn Ala 
        35                  40                  45              


Leu Gln Thr Glu Lys Gly Glu Ser Cys Pro Glu Ile Pro Asn Leu Pro 
    50                  55                  60                  


Asn Gly Met Gly Glu Thr Arg Leu Ser Glu Asp Glu Thr Ser Asp Asp 
65                  70                  75                  80  


Gly Glu Glu Phe Thr Pro Pro Ile Met Lys Glu Leu Glu Asn Leu Ser 
                85                  90                  95      


Pro Glu Glu Ala Ala His Gln Lys Ala Val Val Glu Arg Leu Leu Gln 
            100                 105                 110         


Glu Asp Pro Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln 
        115                 120                 125             


His Asn Ile Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln 
    130                 135                 140                 


Ser His Leu Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln 
145                 150                 155                 160 


Lys Arg Ala Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val 
                165                 170                 175     


Ala Gln Gln Phe Thr His Ala Gly Gln Gly Ile Leu Thr Glu Glu Pro 
            180                 185                 190         


Met Gly Asp Asp Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys 
        195                 200                 205             


Trp Gly Pro Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln 
    210                 215                 220                 


Lys Asn Pro Ser Lys Glu Glu Arg Glu Ala Leu Val Glu Glu Cys Asn 
225                 230                 235                 240 


Arg Ala Glu Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly 
                245                 250                 255     


Leu Gly Ser Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala 
            260                 265                 270         


Asn Arg Arg Lys Glu Glu Ala Phe Arg His Lys Leu Ala Met Asp Asn 
        275                 280                 285             


Phe Ser Gly Pro Gln Pro Thr Ser Ala Pro Pro Leu Thr Pro His Asn 
    290                 295                 300                 


Ser Ser Ser Leu Gln Pro Pro Pro Ala Leu Ser Pro Thr Lys Val His 
305                 310                 315                 320 


Gly Val Arg Tyr Asn Gln Gln Pro Ala Ser Glu Ala Glu Ser Ser Ser 
                325                 330                 335     


Ser Asn His His Gly Asn Ser Ser Met Val Thr Thr Gln Thr Ile Leu 
            340                 345                 350         


His Gln Val Ser Pro Pro Gly Leu Glu Pro Ser Gln Asn Leu Leu Ser 
        355                 360                 365             


Thr Asp Thr Lys Leu Ile Ser Ala Pro Gly Gly Thr Leu Pro Pro Val 
    370                 375                 380                 


Ser Thr Leu Thr Ala Leu His Ser Leu Glu Gln Asn Pro His Ala Leu 
385                 390                 395                 400 


Gly Gln Gln Thr Gln Asn Leu Ile Met Ala Ser Leu Pro Gly Val Met 
                405                 410                 415     


Ala Ile Gly Ala Gly Glu Thr Ser Ser Leu Ala Pro Arg Phe Thr Asn 
            420                 425                 430         


Thr Gly Gly Ser Thr Leu Val Ile Gly Leu Thr Ser Thr Gln Pro Gln 
        435                 440                 445             


Ser Val Pro Val Ile Asn Ser Met Gly Ser Ser Leu Thr Thr Leu Gln 
    450                 455                 460                 


Pro Val Gln Phe Ser Gln Gln Leu His Pro Ser Tyr Gln Gln Pro Leu 
465                 470                 475                 480 


Met Gln Gln Val Gln Ser His Ile Asn Gln Ser Pro Phe Met Ala Thr 
                485                 490                 495     


Met Ala Gln Ile Gln Asn Pro His Ala Leu Tyr Gly Pro Lys Ser Glu 
            500                 505                 510         


Val Ala Gln Tyr Thr His Thr Gly Leu Leu Pro Gln Thr Met Val Ile 
        515                 520                 525             


Thr Asp Thr Ala Asn Leu Ser Ala Leu Thr Asn Leu Thr Pro Thr Lys 
    530                 535                 540                 


Gln Ala Phe Thr Ser Asp Ser Glu Thr His Thr Asp Ser Gly Ile His 
545                 550                 555                 560 


Thr Pro Val Ser Gln Ala Pro Ala Ile His Leu Gln Asn Gln Asp Thr 
                565                 570                 575     


Ala Ile Gln His Leu Gln Ser Gly Pro Arg Leu Thr Pro Ser Pro Ala 
            580                 585                 590         


Val Ser Ser Ser Ser Leu Val Leu Tyr Gln Ser Ser Asp Ser Thr Asn 
        595                 600                 605             


Ser His Ser Gln Leu Leu Pro Ser Thr His Asn Val Ile Glu Thr Phe 
    610                 615                 620                 


Ile Ser Thr Gln Met Ala Ser Ser Thr Gln 
625                 630                 


<210>  69
<211>  563
<212>  PRT
<213>  Salmo salar 

<400>  69

Met Glu Gly Glu Glu Arg Lys Gly Glu Ala Gly Pro Gly Pro Gly Arg 
1               5                   10                  15      


Leu Ser Ala Leu Gln Glu Gln Leu Ile Trp Ala Leu Leu Gly Ser Gly 
            20                  25                  30          


Leu Ser Arg Glu Val Leu Val His Ala Leu Gly Glu Leu Glu Arg Glu 
        35                  40                  45              


Arg Val Thr Pro Gly Ala Glu Lys Gly Asp Arg Gly Asp Gly Glu Ser 
    50                  55                  60                  


Ser Glu Glu Gly Glu Met Asp Phe Pro Pro Pro Ile Phe Gln Glu Leu 
65                  70                  75                  80  


Glu Ala Leu Ala Pro Glu Glu Ala Ala Arg Gln Arg Ala Leu Val Asp 
                85                  90                  95      


Gln Leu Leu Gln Glu Asp Pro Trp Arg Val Ala Lys Leu Val Lys Ser 
            100                 105                 110         


Tyr Met Gln Gln His Asn Leu Pro Gln Arg Glu Val Val Glu Ser Ile 
        115                 120                 125             


Gly Leu Asn Gln Ser His Leu Ser Gln His Leu Asn Lys Gly Thr Pro 
    130                 135                 140                 


Met Lys Asn Gln Lys Arg Ala Ala Leu Tyr Ser Trp Tyr Val Arg Lys 
145                 150                 155                 160 


Gln Gly Glu Ile Ser Gln Gln Phe Thr Asn Ala Arg His Ala Leu Gly 
                165                 170                 175     


Ser Gly Glu Glu Gln Gly Glu Asp Val Arg Lys Gly Arg Arg Asn Arg 
            180                 185                 190         


Phe Lys Trp Gly Pro Ala Ser Gln Gln Ile Leu Phe His Ala Tyr Glu 
        195                 200                 205             


Arg Gln Arg Asn Pro Ser Lys Glu Glu Arg Glu Gly Leu Val Glu Glu 
    210                 215                 220                 


Cys Asn Arg Ala Glu Cys Leu Gln Arg Gly Val Ser Pro Ser Gln Leu 
225                 230                 235                 240 


Ala Gly Leu Gly Ser Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp 
                245                 250                 255     


Phe Ala Asn Arg Arg Lys Glu Glu Ala Phe Arg His Lys Leu Ala Leu 
            260                 265                 270         


Asp Met Pro Tyr Asn Ser Gln Ser Ala Ser Ser Thr Asn His Thr Leu 
        275                 280                 285             


Ser His Ser Pro Glu Gln Gly Met Lys Tyr Ser Gln Gln Ile Thr Cys 
    290                 295                 300                 


Asp Asn Leu Gly Ser Ser Arg Gly His Asn Gly Asp Arg Gly Leu Gly 
305                 310                 315                 320 


Gly Arg Leu Ala Ser Pro Ile Gln Leu Glu Pro Ser His Thr Leu Leu 
                325                 330                 335     


Glu Thr His His His Lys Pro Val Ser Gly Gly Gly Pro Leu Pro Pro 
            340                 345                 350         


Val Ser Thr Leu Thr Ser Leu His Ser Leu Ser Ala Ser Pro Ala Pro 
        355                 360                 365             


His His Gly Leu Ile Met Thr Ser Leu Pro Ser Val Met Ser Leu Gly 
    370                 375                 380                 


Glu Ser Ser Leu Leu Ile Gly Gln Thr Val Pro Val Ile Asn Asn Val 
385                 390                 395                 400 


Gly Gly Gly Phe Thr Thr Leu Gln Pro Ile Ser Phe Gln Gln Gln Leu 
                405                 410                 415     


His Ser Thr Ser Gln Gln Gln Leu Thr Gln Gln Phe Gln Ser His Met 
            420                 425                 430         


Gly His His His Ser Pro Phe Met Ala Thr Met Ala Gln Leu Pro Cys 
        435                 440                 445             


His Met Tyr Ser Lys Ser Asp Met Ser His Tyr Pro Pro Ser Ser Leu 
    450                 455                 460                 


Leu Ser Gln Ala Met Val Ile Thr Asp Ser Ser Ser Leu Gly Thr Leu 
465                 470                 475                 480 


Thr Ser Leu Thr Thr Val Arg Gln Ile Leu Thr Thr Asp Pro Glu Glu 
                485                 490                 495     


Gln Thr Asp Gln Pro Ile Gln Glu Asp Ser Leu His Leu Gln Ser Pro 
            500                 505                 510         


Ser Pro Val Pro Val Ser Ser Gly Asn Leu Gln Leu Tyr Pro Pro Ser 
        515                 520                 525             


Gln Ser Ser Glu Ser His Pro Pro His Arg Leu Ser Ser Ser Pro Ala 
    530                 535                 540                 


Asp Ile Asn Ser Tyr Ile Pro Ala Gln Met Val Ser Thr Ala Gln His 
545                 550                 555                 560 


Ile Asp Glu 
            


<210>  70
<211>  457
<212>  PRT
<213>  Homo sapiens 

<400>  70

Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      


Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              


Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  


Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  


Ser Pro Gly Ala Gly Ala Met Ala Gly Met Gly Gly Ser Ala Gly Ala 
                85                  90                  95      


Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         


Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             


Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 


Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 


Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     


Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         


Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             


His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 


Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 


Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     


Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Gly Ser 
            260                 265                 270         


Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala Ser Gln Ala Gln Leu Gly 
        275                 280                 285             


Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser Pro 
    290                 295                 300                 


His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu Gly 
305                 310                 315                 320 


Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu Ser Pro Pro Glu Pro Ala 
                325                 330                 335     


Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly Pro 
            340                 345                 350         


Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu His 
        355                 360                 365             


His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser 
    370                 375                 380                 


Glu Gln Gln His His His Ser His His His His Gln Pro His Lys Met 
385                 390                 395                 400 


Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Tyr Gly Ser 
                405                 410                 415     


Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys Thr Gly 
            420                 425                 430         


Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln Gly Val 
        435                 440                 445             


Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455         


<210>  71
<211>  459
<212>  PRT
<213>  Mus musculus 

<400>  71

Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      


Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              


Ala Ala Met Gly Gly Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  


Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  


Ser Pro Gly Ala Gly Ala Met Ala Gly Met Ser Gly Ser Ala Gly Ala 
                85                  90                  95      


Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         


Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             


Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 


Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 


Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     


Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         


Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             


His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 


Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 


Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     


Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Ser Ser 
            260                 265                 270         


Gly Gly Lys Lys Thr Ala Pro Gly Ser Gln Ala Ser Gln Ala Gln Leu 
        275                 280                 285             


Gly Glu Ala Ala Gly Ser Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser 
    290                 295                 300                 


Pro His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu 
305                 310                 315                 320 


Ser Glu Leu Lys Gly Ala Pro Ala Ser Ala Leu Ser Pro Pro Glu Pro 
                325                 330                 335     


Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly 
            340                 345                 350         


Pro Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu 
        355                 360                 365             


His His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser 
    370                 375                 380                 


Ser Glu Gln Gln His His His Ser His His His His Gln Pro His Lys 
385                 390                 395                 400 


Met Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Gly Tyr 
                405                 410                 415     


Gly Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys 
            420                 425                 430         


Ala Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln 
        435                 440                 445             


Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455                 


<210>  72
<211>  458
<212>  PRT
<213>  Rattus norvegicus 

<400>  72

Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      


Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Ser Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              


Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  


Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  


Ser Pro Gly Ala Gly Ala Met Ala Gly Met Ser Gly Ser Ala Gly Ala 
                85                  90                  95      


Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         


Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             


Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 


Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 


Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     


Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         


Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             


His Ser Leu Ser Phe Asn Asp Phe Leu Lys Val Pro Arg Ala Pro Asp 
    210                 215                 220                 


Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly Asn 
225                 230                 235                 240 


Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys 
                245                 250                 255     


Glu Asn Glu Leu Ala Leu Lys Glu Ala Ala Gly Ala Gly Ser Gly Gly 
            260                 265                 270         


Gly Lys Lys Thr Ala Pro Gly Thr Gln Ala Ser Gln Val Gln Leu Gly 
        275                 280                 285             


Glu Ala Ala Gly Ser Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser Pro 
    290                 295                 300                 


His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu Ser 
305                 310                 315                 320 


Glu Leu Lys Gly Thr Pro Ala Ser Ala Leu Ser Pro Pro Glu Pro Ala 
                325                 330                 335     


Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly Pro 
            340                 345                 350         


Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu His 
        355                 360                 365             


His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser 
    370                 375                 380                 


Glu Gln Gln His His His Ser His His His His Gln Pro His Lys Met 
385                 390                 395                 400 


Asp Leu Lys Thr Tyr Glu Gln Val Met His Tyr Pro Gly Gly Tyr Gly 
                405                 410                 415     


Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys Ala 
            420                 425                 430         


Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln Gly 
        435                 440                 445             


Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455             


<210>  73
<211>  415
<212>  PRT
<213>  Oryzias latipes 

<400>  73

Met Met Leu Gly Ala Val Lys Met Glu Gly His Glu His Thr Asp Trp 
1               5                   10                  15      


Ser Thr Tyr Tyr Gly Glu Pro Glu Cys Tyr Thr Ser Val Gly Asn Met 
            20                  25                  30          


Asn Thr Gly Leu Gly Met Asn Ser Met Asn Thr Tyr Met Ser Met Ser 
        35                  40                  45              


Gly Met Ser Thr Thr Ala Asn Met Thr Ala Asn Ser Met Asn Met Ser 
    50                  55                  60                  


Tyr Val Asn Thr Gly Met Ser Pro Ser Met Thr Gly Met Ser Pro Gly 
65                  70                  75                  80  


Thr Gly Ala Met Asn Gly Met Gly Ala Gly Met Thr Ala Met Ser Thr 
                85                  90                  95      


Ala Leu Ser Pro Ser Met Ser Pro Met Thr Gly Gln Pro Gly Ser Met 
            100                 105                 110         


Asn Ala Leu Thr Ser Tyr Thr Asn Met Asn Ala Met Ser Pro Ile Tyr 
        115                 120                 125             


Gly Gln Ser Asn Ile Asn Arg Ser Arg Asp Pro Lys Thr Tyr Arg Arg 
    130                 135                 140                 


Ser Tyr Thr His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr 
145                 150                 155                 160 


Met Ala Ile Gln Gln Ser Pro Ser Lys Met Leu Thr Leu Ala Glu Ile 
                165                 170                 175     


Tyr Gln Trp Ile Met Asp Leu Phe Pro Phe Tyr Arg Gln Asn Gln Gln 
            180                 185                 190         


Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe 
        195                 200                 205             


Leu Lys Val Pro Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Phe Trp 
    210                 215                 220                 


Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu 
225                 230                 235                 240 


Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Lys Met Ser Met Lys Glu 
                245                 250                 255     


Pro Gly Arg Lys Gly Gly Asp Gly Gly Ser Ala Asn Ser Ser Ser Asp 
            260                 265                 270         


Ser Cys Asn Gly Asn Glu Ser Pro His Ser Asn Ser Ser Ser Gly Glu 
        275                 280                 285             


His Lys Arg Ser Leu Ser Asp Met Lys Gly Ser Gln Ala Leu Ser Pro 
    290                 295                 300                 


Glu His Thr Ala Pro Ser Pro Val Ser Gln Gly Gln His Leu Met Ser 
305                 310                 315                 320 


Gln His His Ser Val Leu Ala His Glu Ala His Leu Lys Pro Glu His 
                325                 330                 335     


His Tyr Ser Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser 
            340                 345                 350         


Glu Gln Gln His His Lys Met Asp Leu Lys Thr Tyr Glu Gln Val Met 
        355                 360                 365             


His Tyr Ser Gly Tyr Gly Ser Pro Met Thr Gly Ala Leu Ser Met Gly 
    370                 375                 380                 


Ser Met Ala Gly Lys Ala Gly Leu Asp Ser Ala Ser Ile Pro Asp Thr 
385                 390                 395                 400 


Ser Tyr Tyr Gln Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
                405                 410                 415 


<210>  74
<211>  442
<212>  PRT
<213>  Gallus gallus 

<400>  74

Met Leu Gly Ala Val Lys Met Glu Gly His Glu His Thr Asp Trp Ser 
1               5                   10                  15      


Asn Tyr Tyr Gly Glu Pro Glu Ser Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Gly Leu Gly Met Asn Ser Met Asn Thr Tyr Met Thr Met Ser Ala 
        35                  40                  45              


Met Ser Thr Thr Ala Asn Met Thr Ala Ala Thr Ser Met Asn Met Ser 
    50                  55                  60                  


Tyr Ala Asn Thr Gly Met Ser Pro Ser Leu Ala Gly Met Ser Pro Gly 
65                  70                  75                  80  


Ala Gly Ala Met Ala Gly Met Gly Ser Ala Gly Val Ala Gly Met Gly 
                85                  90                  95      


Ala His Leu Ser Pro Ser Met Ser Pro Met Gly Gly Gln Ala Gly Ser 
            100                 105                 110         


Met Asn Ala Leu Ala Pro Tyr Thr Asn Met Asn Ser Met Ser Pro Ile 
        115                 120                 125             


Tyr Gly Gln Ser Asn Leu Asn Arg Ser Arg Asp Pro Lys Thr Tyr Arg 
    130                 135                 140                 


Arg Ser Tyr Thr His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile 
145                 150                 155                 160 


Thr Met Ala Ile Gln Gln Ser Pro Asn Lys Met Leu Thr Leu Ser Glu 
                165                 170                 175     


Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Phe Tyr Arg Gln Asn Gln 
            180                 185                 190         


Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys 
        195                 200                 205             


Phe Leu Lys Val Pro Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Phe 
    210                 215                 220                 


Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr 
225                 230                 235                 240 


Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Leu Ala Thr Lys 
                245                 250                 255     


Asp Gly Gly Gly Gly Lys Lys Gly Pro Gly Gln Pro Pro Ser Gln Pro 
            260                 265                 270         


Leu Gly Glu Gly Ser Ser Ser Gly Gly Ser Glu Gly Ser Ala Gly Ala 
        275                 280                 285             


Glu Ser Pro Ala Ser Ala Ser Pro Cys Arg Asp Asn Lys Arg Ala Leu 
    290                 295                 300                 


Ala Glu Leu Lys Gly Ala Ala Ala Gly Pro Ser Pro Gly Glu Pro Ser 
305                 310                 315                 320 


Ala Ala Ser Pro Ala His His Leu Leu Ala Pro Pro His Ala Gly Leu 
                325                 330                 335     


Pro His Asp Ala His Leu Lys Pro Glu His His Tyr Ala Phe Asn His 
            340                 345                 350         


Pro Phe Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His His 
        355                 360                 365             


His His Pro His His His His His Pro Ser His Lys Met Asp Leu Lys 
    370                 375                 380                 


Ala Tyr Glu Gln Val Met His Tyr Ser Gly Tyr Ala Ser Pro Val Pro 
385                 390                 395                 400 


Ala Ser Leu Ala Met Gly Pro Val Thr Asn Lys Asn Pro Leu Glu Ser 
                405                 410                 415     


Ser Pro Leu Ala Gly Glu Thr Ser Tyr Tyr Gln Gly Val Tyr Ser Arg 
            420                 425                 430         


Pro Ile Met Asn Ser Ser His Ile Asp Glu 
        435                 440         


<210>  75
<211>  474
<212>  PRT
<213>  Homo sapiens 

<400>  75

Met Arg Leu Ser Lys Thr Leu Val Asp Met Asp Met Ala Asp Tyr Ser 
1               5                   10                  15      


Ala Ala Leu Asp Pro Ala Tyr Thr Thr Leu Glu Phe Glu Asn Val Gln 
            20                  25                  30          


Val Leu Thr Met Gly Asn Asp Thr Ser Pro Ser Glu Gly Thr Asn Leu 
        35                  40                  45              


Asn Ala Pro Asn Ser Leu Gly Val Ser Ala Leu Cys Ala Ile Cys Gly 
    50                  55                  60                  


Asp Arg Ala Thr Gly Lys His Tyr Gly Ala Ser Ser Cys Asp Gly Cys 
65                  70                  75                  80  


Lys Gly Phe Phe Arg Arg Ser Val Arg Lys Asn His Met Tyr Ser Cys 
                85                  90                  95      


Arg Phe Ser Arg Gln Cys Val Val Asp Lys Asp Lys Arg Asn Gln Cys 
            100                 105                 110         


Arg Tyr Cys Arg Leu Lys Lys Cys Phe Arg Ala Gly Met Lys Lys Glu 
        115                 120                 125             


Ala Val Gln Asn Glu Arg Asp Arg Ile Ser Thr Arg Arg Ser Ser Tyr 
    130                 135                 140                 


Glu Asp Ser Ser Leu Pro Ser Ile Asn Ala Leu Leu Gln Ala Glu Val 
145                 150                 155                 160 


Leu Ser Arg Gln Ile Thr Ser Pro Val Ser Gly Ile Asn Gly Asp Ile 
                165                 170                 175     


Arg Ala Lys Lys Ile Ala Ser Ile Ala Asp Val Cys Glu Ser Met Lys 
            180                 185                 190         


Glu Gln Leu Leu Val Leu Val Glu Trp Ala Lys Tyr Ile Pro Ala Phe 
        195                 200                 205             


Cys Glu Leu Pro Leu Asp Asp Gln Val Ala Leu Leu Arg Ala His Ala 
    210                 215                 220                 


Gly Glu His Leu Leu Leu Gly Ala Thr Lys Arg Ser Met Val Phe Lys 
225                 230                 235                 240 


Asp Val Leu Leu Leu Gly Asn Asp Tyr Ile Val Pro Arg His Cys Pro 
                245                 250                 255     


Glu Leu Ala Glu Met Ser Arg Val Ser Ile Arg Ile Leu Asp Glu Leu 
            260                 265                 270         


Val Leu Pro Phe Gln Glu Leu Gln Ile Asp Asp Asn Glu Tyr Ala Tyr 
        275                 280                 285             


Leu Lys Ala Ile Ile Phe Phe Asp Pro Asp Ala Lys Gly Leu Ser Asp 
    290                 295                 300                 


Pro Gly Lys Ile Lys Arg Leu Arg Ser Gln Val Gln Val Ser Leu Glu 
305                 310                 315                 320 


Asp Tyr Ile Asn Asp Arg Gln Tyr Asp Ser Arg Gly Arg Phe Gly Glu 
                325                 330                 335     


Leu Leu Leu Leu Leu Pro Thr Leu Gln Ser Ile Thr Trp Gln Met Ile 
            340                 345                 350         


Glu Gln Ile Gln Phe Ile Lys Leu Phe Gly Met Ala Lys Ile Asp Asn 
        355                 360                 365             


Leu Leu Gln Glu Met Leu Leu Gly Gly Ser Pro Ser Asp Ala Pro His 
    370                 375                 380                 


Ala His His Pro Leu His Pro His Leu Met Gln Glu His Met Gly Thr 
385                 390                 395                 400 


Asn Val Ile Val Ala Asn Thr Met Pro Thr His Leu Ser Asn Gly Gln 
                405                 410                 415     


Met Cys Glu Trp Pro Arg Pro Arg Gly Gln Ala Ala Thr Pro Glu Thr 
            420                 425                 430         


Pro Gln Pro Ser Pro Pro Gly Gly Ser Gly Ser Glu Pro Tyr Lys Leu 
        435                 440                 445             


Leu Pro Gly Ala Val Ala Thr Ile Val Lys Pro Leu Ser Ala Ile Pro 
    450                 455                 460                 


Gln Pro Thr Ile Thr Lys Gln Glu Val Ile 
465                 470                 


<210>  76
<211>  474
<212>  PRT
<213>  Mus musculus 

<400>  76

Met Arg Leu Ser Lys Thr Leu Ala Gly Met Asp Met Ala Asp Tyr Ser 
1               5                   10                  15      


Ala Ala Leu Asp Pro Ala Tyr Thr Thr Leu Glu Phe Glu Asn Val Gln 
            20                  25                  30          


Val Leu Thr Met Gly Asn Asp Thr Ser Pro Ser Glu Gly Ala Asn Leu 
        35                  40                  45              


Asn Ser Ser Asn Ser Leu Gly Val Ser Ala Leu Cys Ala Ile Cys Gly 
    50                  55                  60                  


Asp Arg Ala Thr Gly Lys His Tyr Gly Ala Ser Ser Cys Asp Gly Cys 
65                  70                  75                  80  


Lys Gly Phe Phe Arg Arg Ser Val Arg Lys Asn His Met Tyr Ser Cys 
                85                  90                  95      


Arg Phe Ser Arg Gln Cys Val Val Asp Lys Asp Lys Arg Asn Gln Cys 
            100                 105                 110         


Arg Tyr Cys Arg Leu Lys Lys Cys Phe Arg Ala Gly Met Lys Lys Glu 
        115                 120                 125             


Ala Val Gln Asn Glu Arg Asp Arg Ile Ser Thr Arg Arg Ser Ser Tyr 
    130                 135                 140                 


Glu Asp Ser Ser Leu Pro Ser Ile Asn Ala Leu Leu Gln Ala Glu Val 
145                 150                 155                 160 


Leu Ser Gln Gln Ile Thr Ser Pro Ile Ser Gly Ile Asn Gly Asp Ile 
                165                 170                 175     


Arg Ala Lys Lys Ile Ala Asn Ile Thr Asp Val Cys Glu Ser Met Lys 
            180                 185                 190         


Glu Gln Leu Leu Val Leu Val Glu Trp Ala Lys Tyr Ile Pro Ala Phe 
        195                 200                 205             


Cys Glu Leu Leu Leu Asp Asp Gln Val Ala Leu Leu Arg Ala His Ala 
    210                 215                 220                 


Gly Glu His Leu Leu Leu Gly Ala Thr Lys Arg Ser Met Val Phe Lys 
225                 230                 235                 240 


Asp Val Leu Leu Leu Gly Asn Asp Tyr Ile Val Pro Arg His Cys Pro 
                245                 250                 255     


Glu Leu Ala Glu Met Ser Arg Val Ser Ile Arg Ile Leu Asp Glu Leu 
            260                 265                 270         


Val Leu Pro Phe Gln Glu Leu Gln Ile Asp Asp Asn Glu Tyr Ala Cys 
        275                 280                 285             


Leu Lys Ala Ile Ile Phe Phe Asp Pro Asp Ala Lys Gly Leu Ser Asp 
    290                 295                 300                 


Pro Gly Lys Ile Lys Arg Leu Arg Ser Gln Val Gln Val Ser Leu Glu 
305                 310                 315                 320 


Asp Tyr Ile Asn Asp Arg Gln Tyr Asp Ser Arg Gly Arg Phe Gly Glu 
                325                 330                 335     


Leu Leu Leu Leu Leu Pro Thr Leu Gln Ser Ile Thr Trp Gln Met Ile 
            340                 345                 350         


Glu Gln Ile Gln Phe Ile Lys Leu Phe Gly Met Ala Lys Ile Asp Asn 
        355                 360                 365             


Leu Leu Gln Glu Met Leu Leu Gly Gly Ser Ala Ser Asp Ala Pro His 
    370                 375                 380                 


Thr His His Pro Leu His Pro His Leu Met Gln Glu His Met Gly Thr 
385                 390                 395                 400 


Asn Val Ile Val Ala Asn Thr Met Pro Ser His Leu Ser Asn Gly Gln 
                405                 410                 415     


Met Cys Glu Trp Pro Arg Pro Arg Gly Gln Ala Ala Thr Pro Glu Thr 
            420                 425                 430         


Pro Gln Pro Ser Pro Pro Ser Gly Ser Gly Ser Glu Ser Tyr Lys Leu 
        435                 440                 445             


Leu Pro Gly Ala Ile Thr Thr Ile Val Lys Pro Pro Ser Ala Ile Pro 
    450                 455                 460                 


Gln Pro Thr Ile Thr Lys Gln Glu Ala Ile 
465                 470                 


<210>  77
<211>  474
<212>  PRT
<213>  Rattus norvegicus 

<400>  77

Met Arg Leu Ser Lys Thr Leu Ala Asp Met Asp Met Ala Asp Tyr Ser 
1               5                   10                  15      


Ala Ala Leu Asp Pro Ala Tyr Thr Thr Leu Glu Phe Glu Asn Val Gln 
            20                  25                  30          


Val Leu Thr Met Gly Asn Asp Thr Ser Pro Ser Glu Gly Ala Asn Leu 
        35                  40                  45              


Asn Ser Ser Asn Ser Leu Gly Val Ser Ala Leu Cys Ala Ile Cys Gly 
    50                  55                  60                  


Asp Arg Ala Thr Gly Lys His Tyr Gly Ala Ser Ser Cys Asp Gly Cys 
65                  70                  75                  80  


Lys Gly Phe Phe Arg Arg Ser Val Arg Lys Asn His Met Tyr Ser Cys 
                85                  90                  95      


Arg Phe Ser Arg Gln Cys Val Val Asp Lys Asp Lys Arg Asn Gln Cys 
            100                 105                 110         


Arg Tyr Cys Arg Leu Lys Lys Cys Phe Arg Ala Gly Met Lys Lys Glu 
        115                 120                 125             


Ala Val Gln Asn Glu Arg Asp Arg Ile Ser Thr Arg Arg Ser Ser Tyr 
    130                 135                 140                 


Glu Asp Ser Ser Leu Pro Ser Ile Asn Ala Leu Leu Gln Ala Glu Val 
145                 150                 155                 160 


Leu Ser Gln Gln Ile Thr Ser Pro Ile Ser Gly Ile Asn Gly Asp Ile 
                165                 170                 175     


Arg Ala Lys Lys Ile Ala Asn Ile Thr Asp Val Cys Glu Ser Met Lys 
            180                 185                 190         


Glu Gln Leu Leu Val Leu Val Glu Trp Ala Lys Tyr Ile Pro Ala Phe 
        195                 200                 205             


Cys Glu Leu Leu Leu Asp Asp Gln Val Ala Leu Leu Arg Ala His Ala 
    210                 215                 220                 


Gly Glu His Leu Leu Leu Gly Ala Thr Lys Arg Ser Met Val Phe Lys 
225                 230                 235                 240 


Asp Val Leu Leu Leu Gly Asn Asp Tyr Ile Val Pro Arg His Cys Pro 
                245                 250                 255     


Glu Leu Ala Glu Met Ser Arg Val Ser Ile Arg Ile Leu Asp Glu Leu 
            260                 265                 270         


Val Leu Pro Phe Gln Glu Leu Gln Ile Asp Asp Asn Glu Tyr Ala Cys 
        275                 280                 285             


Leu Lys Ala Ile Ile Phe Phe Asp Pro Asp Ala Lys Gly Leu Ser Asp 
    290                 295                 300                 


Pro Gly Lys Ile Lys Arg Leu Arg Ser Gln Val Gln Val Ser Leu Glu 
305                 310                 315                 320 


Asp Tyr Ile Asn Asp Arg Gln Tyr Asp Ser Arg Gly Arg Phe Gly Glu 
                325                 330                 335     


Leu Leu Leu Leu Leu Pro Thr Leu Gln Ser Ile Thr Trp Gln Met Ile 
            340                 345                 350         


Glu Gln Ile Gln Phe Ile Lys Leu Phe Gly Met Ala Lys Ile Asp Asn 
        355                 360                 365             


Leu Leu Gln Glu Met Leu Leu Gly Gly Ser Ala Ser Asp Ala Pro His 
    370                 375                 380                 


Ala His His Pro Leu His Pro His Leu Met Gln Glu His Met Gly Thr 
385                 390                 395                 400 


Asn Val Ile Val Ala Asn Thr Met Pro Ser His Leu Ser Asn Gly Gln 
                405                 410                 415     


Met Cys Glu Trp Pro Arg Pro Arg Gly Gln Ala Ala Thr Pro Glu Thr 
            420                 425                 430         


Pro Gln Pro Ser Pro Pro Ser Gly Ser Gly Ser Glu Ser Tyr Lys Leu 
        435                 440                 445             


Leu Pro Gly Ala Ile Thr Thr Ile Val Lys Pro Pro Ser Ala Ile Pro 
    450                 455                 460                 


Gln Pro Thr Ile Thr Lys Gln Glu Ala Ile 
465                 470                 


<210>  78
<211>  464
<212>  PRT
<213>  Xenopus laevis 

<400>  78

Met Arg Leu Ser Lys Ala Leu Ile Asp Met Asp Met Ala Asp Tyr Thr 
1               5                   10                  15      


Glu Ala Leu Asp Pro Ala Tyr Thr Thr Leu Glu Phe Glu Asn Met Gln 
            20                  25                  30          


Val Leu Ser Ile Gly Thr Asp Thr Ser Thr Ser Asp Val Thr Ser Leu 
        35                  40                  45              


Ser Ala Ser Asn Ser Ile Gly Ile Asn Ser Leu Cys Ala Ile Cys Gly 
    50                  55                  60                  


Asp Arg Ala Thr Gly Lys His Tyr Gly Ala Ser Ser Cys Asp Gly Cys 
65                  70                  75                  80  


Lys Gly Phe Phe Arg Arg Ser Val Arg Lys Asn His Met Tyr Ser Cys 
                85                  90                  95      


Arg Phe Ser Arg Gln Cys Val Val Asp Lys Asp Lys Arg Asn Gln Cys 
            100                 105                 110         


Arg Tyr Cys Arg Leu Lys Lys Cys Phe Arg Ala Gly Met Lys Lys Glu 
        115                 120                 125             


Ala Val Gln Asn Glu Arg Asp Arg Ile Ser Thr Arg Arg Ser Ser Tyr 
    130                 135                 140                 


Glu Asp Ser Ser Leu Pro Ser Ile Asn Val Leu Ile Gln Ala Glu Val 
145                 150                 155                 160 


Leu Ser Gln Gln Ile Thr Ser Ser Val Gly Val Leu Asn Thr Asp Ile 
                165                 170                 175     


Arg Gly Lys Lys Ile Ala Cys Ile Ile Asp Val Cys Asp Ser Met Lys 
            180                 185                 190         


Gln Gln Leu Leu Val Leu Val Glu Trp Ala Lys Tyr Ile Pro Ala Phe 
        195                 200                 205             


Cys Glu Leu Pro Leu Asp Asp Gln Val Ala Leu Leu Arg Ala His Ala 
    210                 215                 220                 


Gly Glu His Leu Leu Leu Gly Ala Thr Lys Arg Ser Met Met Phe Lys 
225                 230                 235                 240 


Asp Ile Leu Leu Leu Gly Asn Asp Arg Leu Ile Pro Arg Asn Cys Pro 
                245                 250                 255     


Glu Leu Glu Val Gly Arg Val Ala Val Arg Ile Leu Asp Glu Leu Val 
            260                 265                 270         


Leu Pro Phe Gln Glu Leu Gln Ile Asp Asp Asn Glu Tyr Ala Cys Leu 
        275                 280                 285             


Lys Ala Ile Ile Phe Phe Asp Pro Asp Ala Lys Gly Leu Ser Asp Pro 
    290                 295                 300                 


Thr Lys Ile Lys Arg Met Arg Tyr Gln Val Gln Val Ser Leu Glu Asp 
305                 310                 315                 320 


Tyr Ile Asn Asp Arg Gln Tyr Asp Ser Arg Gly Arg Phe Gly Glu Leu 
                325                 330                 335     


Leu Leu Leu Leu Pro Thr Leu Gln Ser Ile Thr Trp Gln Met Ile Glu 
            340                 345                 350         


Gln Ile Gln Phe Val Lys Leu Phe Gly Met Ala Lys Ile Asp Asn Leu 
        355                 360                 365             


Leu Gln Glu Met Leu Leu Gly Gly Ser Ala Asn Glu Ala Ser His Thr 
    370                 375                 380                 


His His His Leu His Pro His Leu Val Gln Asp His Leu Ala Thr Asn 
385                 390                 395                 400 


Val Ile Val Ala Asn Asn Thr Leu Pro Ser Gln Leu His Asn Gly Gln 
                405                 410                 415     


Met Ser Thr Pro Glu Thr Pro Gln Pro Ser Pro Pro Ala Gly Ser Gly 
            420                 425                 430         


Ala Glu Gln Tyr Lys Ile Val His Gly Thr Ile Ala Ser Ile Asn Lys 
        435                 440                 445             


Gln Pro Thr Ser Ile Pro Gln Ser Thr Ile Thr Lys Gln Glu Ala Met 
    450                 455                 460                 



