                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  USE OF POLYPEPTIDES HAVING PROTEASE ACTIVITY IN ANIMAL FEED AND 
       DETERGENTS

<130>  12163

<150>  EP12172756.4
<151>  2012-06-20

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1146
<212>  DNA
<213>  Saccharomonospora viridis


<220>
<221>  CDS
<222>  (1)..(1143)

<220>
<221>  sig_peptide
<222>  (1)..(96)

<220>
<221>  mat_peptide
<222>  (595)..(1074)

<400>  1
atg cta ccg aag  aag cac aga ctc gtg  gct cgg atg acc gcg  acc          45
Met Leu Pro Lys  Lys His Arg Leu Val  Ala Arg Met Thr Ala  Thr            
            -195                 -190                 -185                

gcg atg ctg gct  gcg gga acg gcc gcg  gcg gtc gcc ctg ccc  gcg          90
Ala Met Leu Ala  Ala Gly Thr Ala Ala  Ala Val Ala Leu Pro  Ala            
            -180                 -175                 -170                

acc gcg gaa acg  gtg aca ccg cag acg  gaa gtc acg gcc gag  gcg         135
Thr Ala Glu Thr  Val Thr Pro Gln Thr  Glu Val Thr Ala Glu  Ala            
            -165                 -160                 -155                

gac ccg atg ctg  cag gcc atg cag cgc  gac ctg gga ctg acg  gcc         180
Asp Pro Met Leu  Gln Ala Met Gln Arg  Asp Leu Gly Leu Thr  Ala            
            -150                 -145                 -140                

cag gag gcg caa  cag cgg ctg gag cag  gag tct gtg gcg cgc  acg         225
Gln Glu Ala Gln  Gln Arg Leu Glu Gln  Glu Ser Val Ala Arg  Thr            
            -135                 -130                 -125                

ctg gac gag acc  ctg cgc gcc aag ttg  cag gac aac ttc gga  ggc         270
Leu Asp Glu Thr  Leu Arg Ala Lys Leu  Gln Asp Asn Phe Gly  Gly            
            -120                 -115                 -110                

tcg tac tac gac  gcc gac acc ggg acc  ctg gtg gtg ggt gtg acc gag      318
Ser Tyr Tyr Asp  Ala Asp Thr Gly Thr  Leu Val Val Gly Val Thr Glu         
            -105                 -100                 -95                 

gcg tcc gcg ttg gac gac gtg cgg gcc gcc ggc gcc aag gcc aag ctc        366
Ala Ser Ala Leu Asp Asp Val Arg Ala Ala Gly Ala Lys Ala Lys Leu           
        -90                 -85                 -80                       

gtc gac gcc agc atc gac gaa ctc aac acg gcg gtg gac cgg ctc gac        414
Val Asp Ala Ser Ile Asp Glu Leu Asn Thr Ala Val Asp Arg Leu Asp           
    -75                 -70                 -65                           

cgc aag gaa agc agc gcc ccc gaa tcg gtc acc ggc tgg tac gtc gac        462
Arg Lys Glu Ser Ser Ala Pro Glu Ser Val Thr Gly Trp Tyr Val Asp           
-60                 -55                 -50                 -45           

gtc aag aac aac tcg gtg gtc gtc acc acc gcg ccc ggc acg gcc gcg        510
Val Lys Asn Asn Ser Val Val Val Thr Thr Ala Pro Gly Thr Ala Ala           
                -40                 -35                 -30               

cag gcc gag aaa ttc gtg gcg gcg tcc ggg gtc gac ggt gac aac gtc        558
Gln Ala Glu Lys Phe Val Ala Ala Ser Gly Val Asp Gly Asp Asn Val           
            -25                 -20                 -15                   

gag atc gtg gag tcc acc gaa cag ccc cgc acc ttc atg gac gtc atc        606
Glu Ile Val Glu Ser Thr Glu Gln Pro Arg Thr Phe Met Asp Val Ile           
        -10                 -5              -1  1                         

ggc ggc aac gcc tac tac atg ggt aat ggc ggt cgt tgc tcg gtc gga        654
Gly Gly Asn Ala Tyr Tyr Met Gly Asn Gly Gly Arg Cys Ser Val Gly           
5                   10                  15                  20            

ttc acc gtg cag ggc ggc ttc gtg acc gcc ggc cac tgc ggc acc acc        702
Phe Thr Val Gln Gly Gly Phe Val Thr Ala Gly His Cys Gly Thr Thr           
                25                  30                  35                

ggc acc tcc acg tcg tcg ccc agc ggc acc ttc gcc ggc tcg tcg ttc        750
Gly Thr Ser Thr Ser Ser Pro Ser Gly Thr Phe Ala Gly Ser Ser Phe           
            40                  45                  50                    

ccg ggc aac gac tac gcc ttc gtc cgc acc ggt tcc ggt gac acg ctg        798
Pro Gly Asn Asp Tyr Ala Phe Val Arg Thr Gly Ser Gly Asp Thr Leu           
        55                  60                  65                        

cgc ccg tgg gtc aac atg tac aac ggc tcc gct cgc gtc gtc tcc ggc        846
Arg Pro Trp Val Asn Met Tyr Asn Gly Ser Ala Arg Val Val Ser Gly           
    70                  75                  80                            

tcc agc gtg gcc ccg gtc ggc tcg tcg atc tgc cgc tcg ggt tcc acc        894
Ser Ser Val Ala Pro Val Gly Ser Ser Ile Cys Arg Ser Gly Ser Thr           
85                  90                  95                  100           

acc ggc tgg cac tgc ggc cag gtc cag gcc ttc aac cag acc gtg cgt        942
Thr Gly Trp His Cys Gly Gln Val Gln Ala Phe Asn Gln Thr Val Arg           
                105                 110                 115               

tac gcg gag ggc acc gtc acc ggt ctg acc cgc acc aac gtc tgc gcc        990
Tyr Ala Glu Gly Thr Val Thr Gly Leu Thr Arg Thr Asn Val Cys Ala           
            120                 125                 130                   

gag ccg ggt gac tcg ggt ggc tcg ttc atc tcg ggc aac cag gct cag       1038
Glu Pro Gly Asp Ser Gly Gly Ser Phe Ile Ser Gly Asn Gln Ala Gln           
        135                 140                 145                       

ggc atg acc tcc ggt ggc tcc ggt aac tgc acc ttc ggt ggc acc acg       1086
Gly Met Thr Ser Gly Gly Ser Gly Asn Cys Thr Phe Gly Gly Thr Thr           
    150                 155                 160                           

tac ttc cag ccg gtc aac gaa gta ctg agc gcc tac aac ctg agg ctg       1134
Tyr Phe Gln Pro Val Asn Glu Val Leu Ser Ala Tyr Asn Leu Arg Leu           
165                 170                 175                 180           

atc acc ggc tga                                                       1146
Ile Thr Gly                                                               
                                                                          


<210>  2
<211>  381
<212>  PRT
<213>  Saccharomonospora viridis

<400>  2

Met Leu Pro Lys  Lys His Arg Leu Val  Ala Arg Met Thr Ala  Thr 
            -195                 -190                 -185     


Ala Met Leu Ala  Ala Gly Thr Ala Ala  Ala Val Ala Leu Pro  Ala 
            -180                 -175                 -170     


Thr Ala Glu Thr  Val Thr Pro Gln Thr  Glu Val Thr Ala Glu  Ala 
            -165                 -160                 -155     


Asp Pro Met Leu  Gln Ala Met Gln Arg  Asp Leu Gly Leu Thr  Ala 
            -150                 -145                 -140     


Gln Glu Ala Gln  Gln Arg Leu Glu Gln  Glu Ser Val Ala Arg  Thr 
            -135                 -130                 -125     


Leu Asp Glu Thr  Leu Arg Ala Lys Leu  Gln Asp Asn Phe Gly  Gly 
            -120                 -115                 -110     


Ser Tyr Tyr Asp  Ala Asp Thr Gly Thr  Leu Val Val Gly Val Thr Glu 
            -105                 -100                 -95         


Ala Ser Ala Leu Asp Asp Val Arg Ala Ala Gly Ala Lys Ala Lys Leu 
        -90                 -85                 -80             


Val Asp Ala Ser Ile Asp Glu Leu Asn Thr Ala Val Asp Arg Leu Asp 
    -75                 -70                 -65                 


Arg Lys Glu Ser Ser Ala Pro Glu Ser Val Thr Gly Trp Tyr Val Asp 
-60                 -55                 -50                 -45 


Val Lys Asn Asn Ser Val Val Val Thr Thr Ala Pro Gly Thr Ala Ala 
                -40                 -35                 -30     


Gln Ala Glu Lys Phe Val Ala Ala Ser Gly Val Asp Gly Asp Asn Val 
            -25                 -20                 -15         


Glu Ile Val Glu Ser Thr Glu Gln Pro Arg Thr Phe Met Asp Val Ile 
        -10                 -5              -1  1               


Gly Gly Asn Ala Tyr Tyr Met Gly Asn Gly Gly Arg Cys Ser Val Gly 
5                   10                  15                  20  


Phe Thr Val Gln Gly Gly Phe Val Thr Ala Gly His Cys Gly Thr Thr 
                25                  30                  35      


Gly Thr Ser Thr Ser Ser Pro Ser Gly Thr Phe Ala Gly Ser Ser Phe 
            40                  45                  50          


Pro Gly Asn Asp Tyr Ala Phe Val Arg Thr Gly Ser Gly Asp Thr Leu 
        55                  60                  65              


Arg Pro Trp Val Asn Met Tyr Asn Gly Ser Ala Arg Val Val Ser Gly 
    70                  75                  80                  


Ser Ser Val Ala Pro Val Gly Ser Ser Ile Cys Arg Ser Gly Ser Thr 
85                  90                  95                  100 


Thr Gly Trp His Cys Gly Gln Val Gln Ala Phe Asn Gln Thr Val Arg 
                105                 110                 115     


Tyr Ala Glu Gly Thr Val Thr Gly Leu Thr Arg Thr Asn Val Cys Ala 
            120                 125                 130         


Glu Pro Gly Asp Ser Gly Gly Ser Phe Ile Ser Gly Asn Gln Ala Gln 
        135                 140                 145             


Gly Met Thr Ser Gly Gly Ser Gly Asn Cys Thr Phe Gly Gly Thr Thr 
    150                 155                 160                 


Tyr Phe Gln Pro Val Asn Glu Val Leu Ser Ala Tyr Asn Leu Arg Leu 
165                 170                 175                 180 


Ile Thr Gly 
            


<210>  3
<211>  160
<212>  PRT
<213>  Saccharomonospora viridis


<220>
<221>  mat_peptide
<222>  (1)..(160)

<400>  3

Met Asp Val Ile Gly Gly Asn Ala Tyr Tyr Met Gly Asn Gly Gly Arg 
1               5                   10                  15      


Cys Ser Val Gly Phe Thr Val Gln Gly Gly Phe Val Thr Ala Gly His 
            20                  25                  30          


Cys Gly Thr Thr Gly Thr Ser Thr Ser Ser Pro Ser Gly Thr Phe Ala 
        35                  40                  45              


Gly Ser Ser Phe Pro Gly Asn Asp Tyr Ala Phe Val Arg Thr Gly Ser 
    50                  55                  60                  


Gly Asp Thr Leu Arg Pro Trp Val Asn Met Tyr Asn Gly Ser Ala Arg 
65                  70                  75                  80  


Val Val Ser Gly Ser Ser Val Ala Pro Val Gly Ser Ser Ile Cys Arg 
                85                  90                  95      


Ser Gly Ser Thr Thr Gly Trp His Cys Gly Gln Val Gln Ala Phe Asn 
            100                 105                 110         


Gln Thr Val Arg Tyr Ala Glu Gly Thr Val Thr Gly Leu Thr Arg Thr 
        115                 120                 125             


Asn Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Phe Ile Ser Gly 
    130                 135                 140                 


Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser Gly Asn Cys Thr Phe 
145                 150                 155                 160 


<210>  4
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacillus lentus secretion signal


<220>
<221>  sig_peptide
<222>  (1)..(27)

<400>  4

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala 
            20                  25          


<210>  5
<211>  1596
<212>  DNA
<213>  Nocardiopsis sp.


<220>
<221>  CDS
<222>  (318)..(1463)

<220>
<221>  sig_peptide
<222>  (318)..(404)

<220>
<221>  mat_peptide
<222>  (900)..(1463)

<400>  5
acgtttggta cgggtaccgg tgtccgcatg tggccagaat gcccccttgc gacagggaac       60

ggattcggtc ggtagcgcat cgactccgac aaccgcgagg tggccgttcg cgtcgccacg      120

ttctgcgacc gtcatgcgac ccatcatcgg gtgaccccac cgagctctga atggtccacc      180

gttctgacgg tctttccctc accaaaacgt gcacctatgg ttaggacgtt gtttaccgaa      240

tgtctcggtg aacgacaggg gccggacggt attcggcccc gatcccccgt tgatcccccc      300

aggagagtag ggacccc atg cga ccc tcc ccc  gtt gtc tcc gcc atc  ggt       350
                   Met Arg Pro Ser Pro  Val Val Ser Ala Ile  Gly          
                                   -190                 -185              

acg gga gcg ctg  gcc ttc ggt ctg gcg  ctg tcc ggt acc ccg  ggt         395
Thr Gly Ala Leu  Ala Phe Gly Leu Ala  Leu Ser Gly Thr Pro  Gly            
            -180                 -175                 -170                

gcc ctc gcg gcc  acc gga gcg ctc ccc  cag tca ccc acc ccg  gag         440
Ala Leu Ala Ala  Thr Gly Ala Leu Pro  Gln Ser Pro Thr Pro  Glu            
            -165                 -160                 -155                

gcc gac gcg gtc  tcc atg cag gag gcg  ctc cag cgc gac ctc  gac         485
Ala Asp Ala Val  Ser Met Gln Glu Ala  Leu Gln Arg Asp Leu  Asp            
            -150                 -145                 -140                

ctg acc tcc gcc  gag gcc gag gag ctg  ctg gcc gcc cag gac  acc         530
Leu Thr Ser Ala  Glu Ala Glu Glu Leu  Leu Ala Ala Gln Asp  Thr            
            -135                 -130                 -125                

gcc ttc gag gtc  gac gag gcc gcg gcc  gag gcc gcc ggg gac  gcc         575
Ala Phe Glu Val  Asp Glu Ala Ala Ala  Glu Ala Ala Gly Asp  Ala            
            -120                 -115                 -110                

tac ggc ggc tcc  gtc ttc gac acc gag  agc ctg gaa ctg acc gtc ctg      623
Tyr Gly Gly Ser  Val Phe Asp Thr Glu  Ser Leu Glu Leu Thr Val Leu         
            -105                 -100                 -95                 

gtc acc gat gcc gcc gcg gtc gag gcc gtg gag gcc acc ggc gcc ggg        671
Val Thr Asp Ala Ala Ala Val Glu Ala Val Glu Ala Thr Gly Ala Gly           
        -90                 -85                 -80                       

acc gag ctg gtc tcc tac ggc atc gac ggt ctc gac gag atc gtc cag        719
Thr Glu Leu Val Ser Tyr Gly Ile Asp Gly Leu Asp Glu Ile Val Gln           
    -75                 -70                 -65                           

gag ctc aac gcc gcc gac gcc gtt ccc ggt gtg gtc ggc tgg tac ccg        767
Glu Leu Asn Ala Ala Asp Ala Val Pro Gly Val Val Gly Trp Tyr Pro           
-60                 -55                 -50                 -45           

gac gtg gcg ggt gac acc gtc gtc ctg gag gtc ctg gag ggt tcc gga        815
Asp Val Ala Gly Asp Thr Val Val Leu Glu Val Leu Glu Gly Ser Gly           
                -40                 -35                 -30               

gcc gac gtc agc ggc ctg ctc gcg gac gcc ggc gtg gac gcc tcg gcc        863
Ala Asp Val Ser Gly Leu Leu Ala Asp Ala Gly Val Asp Ala Ser Ala           
            -25                 -20                 -15                   

gtc gag gtg acc acg agc gac cag ccc gag ctc tac gcc gac atc atc        911
Val Glu Val Thr Thr Ser Asp Gln Pro Glu Leu Tyr Ala Asp Ile Ile           
        -10                 -5              -1  1                         

ggt ggt ctg gcc tac acc atg ggc ggc cgc tgt tcg gtc ggc ttc gcg        959
Gly Gly Leu Ala Tyr Thr Met Gly Gly Arg Cys Ser Val Gly Phe Ala           
5                   10                  15                  20            

gcc acc aac gcc gcc ggt cag ccc ggg ttc gtc acc gcc ggt cac tgc       1007
Ala Thr Asn Ala Ala Gly Gln Pro Gly Phe Val Thr Ala Gly His Cys           
                25                  30                  35                

ggc cgc gtg ggc acc cag gtg acc atc ggc aac ggc agg ggc gtc ttc       1055
Gly Arg Val Gly Thr Gln Val Thr Ile Gly Asn Gly Arg Gly Val Phe           
            40                  45                  50                    

gag cag tcc gtc ttc ccc ggc aac gac gcg gcc ttc gtc cgc ggt acg       1103
Glu Gln Ser Val Phe Pro Gly Asn Asp Ala Ala Phe Val Arg Gly Thr           
        55                  60                  65                        

tcc aac ttc acg ctg acc aac ctg gtc agc cgc tac aac acc ggc ggg       1151
Ser Asn Phe Thr Leu Thr Asn Leu Val Ser Arg Tyr Asn Thr Gly Gly           
    70                  75                  80                            

tac gcc acg gtc gcc ggt cac aac cag gcc ccc atc ggc tcc tcc gtc       1199
Tyr Ala Thr Val Ala Gly His Asn Gln Ala Pro Ile Gly Ser Ser Val           
85                  90                  95                  100           

tgc cgc tcc ggc tcc acc acc ggt tgg cac tgc ggc acc atc cag gcc       1247
Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln Ala           
                105                 110                 115               

cgc ggc cag tcg gtg agc tac ccc gag ggc acc gtc acc aac atg acc       1295
Arg Gly Gln Ser Val Ser Tyr Pro Glu Gly Thr Val Thr Asn Met Thr           
            120                 125                 130                   

cgg acc acc gtg tgc gcc gag ccc ggc gac tcc ggc ggc tcc tac atc       1343
Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr Ile           
        135                 140                 145                       

tcc ggc acc cag gcc cag ggc gtg acc tcc ggc ggc tcc ggc aac tgc       1391
Ser Gly Thr Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn Cys           
    150                 155                 160                           

cgc acc ggc ggg acc acc ttc tac cag gag gtc acc ccc atg gtg aac       1439
Arg Thr Gly Gly Thr Thr Phe Tyr Gln Glu Val Thr Pro Met Val Asn           
165                 170                 175                 180           

tcc tgg ggc gtc cgt ctc cgg acc tgatccccgc ggttccaggc ggaccgacgg      1493
Ser Trp Gly Val Arg Leu Arg Thr                                           
                185                                                       

tcgtgacctg agtaccaggc gtccccgccg cttccagcgg cgtccgcacc ggggtgggac     1553

cgggcgtggc cacggcccca cccgtgaccg gaccgcccgg cta                       1596


<210>  6
<211>  382
<212>  PRT
<213>  Nocardiopsis sp.

<400>  6

Met Arg Pro Ser Pro  Val Val Ser Ala Ile  Gly Thr Gly Ala Leu  
                -190                 -185                 -180 


Ala Phe Gly Leu Ala  Leu Ser Gly Thr Pro  Gly Ala Leu Ala Ala  
                -175                 -170                 -165 


Thr Gly Ala Leu Pro  Gln Ser Pro Thr Pro  Glu Ala Asp Ala Val  
                -160                 -155                 -150 


Ser Met Gln Glu Ala  Leu Gln Arg Asp Leu  Asp Leu Thr Ser Ala  
                -145                 -140                 -135 


Glu Ala Glu Glu Leu  Leu Ala Ala Gln Asp  Thr Ala Phe Glu Val  
                -130                 -125                 -120 


Asp Glu Ala Ala Ala  Glu Ala Ala Gly Asp  Ala Tyr Gly Gly Ser  
                -115                 -110                 -105 


Val Phe Asp Thr Glu  Ser Leu Glu Leu Thr Val Leu Val Thr Asp Ala 
                -100                 -95                 -90     


Ala Ala Val Glu Ala Val Glu Ala Thr Gly Ala Gly Thr Glu Leu Val 
            -85                 -80                 -75         


Ser Tyr Gly Ile Asp Gly Leu Asp Glu Ile Val Gln Glu Leu Asn Ala 
        -70                 -65                 -60             


Ala Asp Ala Val Pro Gly Val Val Gly Trp Tyr Pro Asp Val Ala Gly 
    -55                 -50                 -45                 


Asp Thr Val Val Leu Glu Val Leu Glu Gly Ser Gly Ala Asp Val Ser 
-40                 -35                 -30                 -25 


Gly Leu Leu Ala Asp Ala Gly Val Asp Ala Ser Ala Val Glu Val Thr 
                -20                 -15                 -10     


Thr Ser Asp Gln Pro Glu Leu Tyr Ala Asp Ile Ile Gly Gly Leu Ala 
            -5              -1  1               5               


Tyr Thr Met Gly Gly Arg Cys Ser Val Gly Phe Ala Ala Thr Asn Ala 
    10                  15                  20                  


Ala Gly Gln Pro Gly Phe Val Thr Ala Gly His Cys Gly Arg Val Gly 
25                  30                  35                  40  


Thr Gln Val Thr Ile Gly Asn Gly Arg Gly Val Phe Glu Gln Ser Val 
                45                  50                  55      


Phe Pro Gly Asn Asp Ala Ala Phe Val Arg Gly Thr Ser Asn Phe Thr 
            60                  65                  70          


Leu Thr Asn Leu Val Ser Arg Tyr Asn Thr Gly Gly Tyr Ala Thr Val 
        75                  80                  85              


Ala Gly His Asn Gln Ala Pro Ile Gly Ser Ser Val Cys Arg Ser Gly 
    90                  95                  100                 


Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln Ala Arg Gly Gln Ser 
105                 110                 115                 120 


Val Ser Tyr Pro Glu Gly Thr Val Thr Asn Met Thr Arg Thr Thr Val 
                125                 130                 135     


Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr Ile Ser Gly Thr Gln 
            140                 145                 150         


Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn Cys Arg Thr Gly Gly 
        155                 160                 165             


Thr Thr Phe Tyr Gln Glu Val Thr Pro Met Val Asn Ser Trp Gly Val 
    170                 175                 180                 


Arg Leu Arg Thr 
185             


<210>  7
<211>  379
<212>  PRT
<213>  Saccharomonospora cyanea

<400>  7

Met Asn Arg Lys Thr Ala Ala Arg Leu Ile Ala Ser Val Thr Leu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Met Ala Phe Thr Leu Pro Ala Thr Ala Ala Pro Ala 
            20                  25                  30          


Ala Pro Asp Ser Val Val Pro Thr Thr Glu Ala Asp Pro Val Val Lys 
        35                  40                  45              


Ala Met Gln Arg Asp Leu Gly Leu Thr Lys Glu Gln Ala Glu Gln Arg 
    50                  55                  60                  


Leu Arg Ser Glu Ala Glu Ala Arg Lys Val His Glu Ala Val Thr Ala 
65                  70                  75                  80  


Asp Leu Gly Ala Asp Phe Ala Gly Ala His Tyr Asp Ala Ala Leu Gly 
                85                  90                  95      


Lys Leu Val Val Gly Val Thr Asp Ala Ala Glu Phe Asp Glu Val Arg 
            100                 105                 110         


Ala Ala Gly Ala Lys Pro Arg Leu Val Glu His Thr Val Ala Asp Leu 
        115                 120                 125             


Glu Gln Ala Ala Ala Ala Leu Asp Ala Lys Glu Asn Ser Ala Pro Glu 
    130                 135                 140                 


Ser Val Thr Gly Trp Tyr Val Asp Val Glu Ala Asn Ser Val Val Val 
145                 150                 155                 160 


Thr Thr Ala Val Gly Thr Ala Glu Gln Ala Glu Arg Phe Val Asp Arg 
                165                 170                 175     


Ala Gly Val Asp Ala Asp Ala Val Ala Val Val Glu Ser Lys Glu Ser 
            180                 185                 190         


Pro Arg Ala Leu Met Asp Ile Ile Gly Gly Asn Ala Tyr Tyr Met Gly 
        195                 200                 205             


Ser Gly Gly Arg Cys Ser Ile Gly Phe Ala Val Gln Gly Gly Phe Val 
    210                 215                 220                 


Thr Ala Gly His Cys Gly Thr Thr Gly Thr Ser Thr Ser Ser Pro Thr 
225                 230                 235                 240 


Gly Arg Phe Ala Gly Ser Ser Phe Pro Gly Asn Asp Tyr Ala Phe Val 
                245                 250                 255     


Gln Thr Gly Ser Gly Asp Thr Leu Arg Pro Trp Val Asn Met Tyr Asn 
            260                 265                 270         


Gly Ser Ala Arg Val Val Ser Gly Ser Ser Glu Ala Pro Val Gly Ser 
        275                 280                 285             


Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile 
    290                 295                 300                 


Gln Ala Lys Asn Gln Thr Val Arg Tyr Ala Glu Gly Thr Val Tyr Gly 
305                 310                 315                 320 


Leu Thr Arg Thr Asn Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser 
                325                 330                 335     


Phe Ile Ser Gly Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser Gly 
            340                 345                 350         


Asn Cys Thr Trp Gly Gly Thr Thr Tyr Phe Gln Pro Val Asn Glu Val 
        355                 360                 365             


Leu Asn Ala Tyr Gly Leu Arg Leu Ile Thr Gly 
    370                 375                 


<210>  8
<211>  378
<212>  PRT
<213>  Saccharomonospora azurea

<400>  8

Met Asn Arg Lys Ser Ala Val Arg Val Leu Ala Ser Val Thr Met Ala 
1               5                   10                  15      


Ala Gly Thr Ala Val Ala Phe Thr Leu Pro Ala Thr Ala Ala Pro Ala 
            20                  25                  30          


Asp Val Ser Val Val Pro Thr Thr Glu Ala Asp Pro Val Val Gln Ala 
        35                  40                  45              


Met Gln Arg Asp Leu Gly Leu Thr Lys Ala Gln Ala Glu Gln Arg Leu 
    50                  55                  60                  


Gln Asp Glu Ala Glu Ala Arg Glu Val His Glu Thr Val Thr Ala Lys 
65                  70                  75                  80  


Leu Gly Ala Glu Tyr Ala Gly Ala His Tyr Asp Ala Asp Arg Gly Thr 
                85                  90                  95      


Leu Val Val Gly Val Thr Asp Ala Ala Glu Phe Asp Ala Val Lys Ala 
            100                 105                 110         


Ala Gly Ala Thr Pro Arg Leu Val Glu Tyr Thr Val Thr Glu Leu Glu 
        115                 120                 125             


Ser Ala Ala Ala Lys Leu Asp Ala Lys Glu Ser Ala Ala Pro Glu Ala 
    130                 135                 140                 


Val Thr Gly Trp Tyr Val Asp Ile Glu Ala Asn Ser Ile Val Val Thr 
145                 150                 155                 160 


Thr Ala Pro Gly Thr Ala Glu Lys Ala Glu Arg Phe Val Asp Arg Ala 
                165                 170                 175     


Gly Val Asp Ala Asp Ala Val Asp Val Val Glu Ser Lys Glu Ser Pro 
            180                 185                 190         


Gln Ala Leu Met Asp Ile Ile Gly Gly Asn Ala Tyr Tyr Met Gly Asn 
        195                 200                 205             


Gly Gly Arg Cys Ser Val Gly Phe Ala Val Gln Gly Gly Phe Val Thr 
    210                 215                 220                 


Ala Gly His Cys Gly Thr Thr Gly Thr Ser Thr Ser Ser Pro Thr Gly 
225                 230                 235                 240 


Arg Phe Ala Gly Ser Ser Phe Pro Gly Asn Asp Tyr Ala Tyr Val Gln 
                245                 250                 255     


Thr Gly Ser Gly Asp Thr Leu Arg Pro Trp Val Asn Met Tyr Asn Gly 
            260                 265                 270         


Ser Ala Arg Val Val Ser Gly Ser Thr Glu Ala Pro Val Gly Ser Ser 
        275                 280                 285             


Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Glu 
    290                 295                 300                 


Ala Lys Asn Gln Thr Val Arg Tyr Ala Glu Gly Ser Val Ser Gly Leu 
305                 310                 315                 320 


Val Arg Thr Asn Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Phe 
                325                 330                 335     


Ile Ala Gly Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser Gly Asn 
            340                 345                 350         


Cys Thr Trp Gly Gly Thr Thr Tyr Tyr Gln Pro Val Asn Glu Val Leu 
        355                 360                 365             


Asn Ala Tyr Gly Leu Arg Leu Ile Thr Gly 
    370                 375             


<210>  9
<211>  377
<212>  PRT
<213>  Saccharomonospora glauca

<400>  9

Met Asn Arg Lys Thr Ala Ala Arg Leu Ile Ala Ser Val Thr Leu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Val Ala Phe Thr Leu Pro Ala Thr Ala Ala Pro Ala 
            20                  25                  30          


Thr Glu Val Ser Thr Thr Ala Ala Asp Pro Val Ile Gln Ala Met Gln 
        35                  40                  45              


Arg Asp Leu Gly Leu Thr Lys Ala Glu Ala Glu Gln Arg Leu Arg Ser 
    50                  55                  60                  


Glu Ala Glu Ala Arg Glu Val His Lys Ala Val Thr Lys Glu Leu Gly 
65                  70                  75                  80  


Ala Asp Phe Ala Gly Ala His Tyr Asp Ala Ala Leu Gly Lys Leu Val 
                85                  90                  95      


Val Gly Val Thr Asp Thr Ala Asp Phe Ala Glu Val Arg Ala Ala Gly 
            100                 105                 110         


Ala Glu Pro Arg Leu Val Glu His Thr Val Ala Glu Leu Glu Lys Ala 
        115                 120                 125             


Ala Lys Ala Leu Asp Ala Lys Glu Ser Ser Ala Pro Asp Ala Val Thr 
    130                 135                 140                 


Gly Trp Tyr Val Asp Val Glu Ala Asn Ser Val Val Val Thr Thr Ala 
145                 150                 155                 160 


Met Gly Thr Ala Glu Gln Ala Glu Arg Phe Val Thr Arg Ala Gly Val 
                165                 170                 175     


Asp Ala Asp Val Val Asp Val Val Glu Ser Thr Glu Ser Pro Arg Thr 
            180                 185                 190         


Phe Met Asp Ile Ile Gly Gly Asn Ala Tyr Tyr Ile Gly Thr Gly Ala 
        195                 200                 205             


Arg Cys Ser Val Gly Phe Ala Val Gln Gly Gly Phe Val Thr Ala Gly 
    210                 215                 220                 


His Cys Gly Ser Thr Gly Ala Thr Thr Ser Ser Pro Ser Gly Arg Phe 
225                 230                 235                 240 


Ala Gly Ser Ser Phe Pro Gly Asn Asp Tyr Ala Tyr Val Gln Thr Gly 
                245                 250                 255     


Ser Gly Asp Thr Pro Arg Gly Leu Val Asn Met Tyr Asn Gly Ser Ala 
            260                 265                 270         


Arg Val Val Ser Gly Ser Thr Val Ala Pro Val Gly Ser Ser Val Cys 
        275                 280                 285             


Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln Ala Thr 
    290                 295                 300                 


Asn Gln Thr Val Arg Tyr Ala Glu Gly Thr Val Ser Gly Leu Thr Arg 
305                 310                 315                 320 


Thr Asn Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Phe Ile Ser 
                325                 330                 335     


Gly Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser Gly Asn Cys Thr 
            340                 345                 350         


Trp Gly Gly Thr Thr Tyr Phe Gln Pro Val Asn Glu Val Leu Asn Ala 
        355                 360                 365             


Tyr Asn Leu Arg Leu Val Thr Gly Gly 
    370                 375         


<210>  10
<211>  375
<212>  PRT
<213>  Saccharomonospora paurometabolica

<400>  10

Met Lys Arg Thr Arg Asn Gly Phe Ala Ala Arg Ala Gly Ala Ala Ala 
1               5                   10                  15      


Val Leu Ala Ala Gly Thr Ala Ala Ala Phe Ala Leu Pro Ala Ser Ala 
            20                  25                  30          


Gln Pro Ala Pro Met Asp Val Asp Pro Gly Met Val Gln Ala Met Glu 
        35                  40                  45              


Arg Asp Leu Gly Leu Ser Gly Thr Gln Ala Glu Gln Arg Leu Arg Ser 
    50                  55                  60                  


Glu Ala Thr Ala Arg Ala Val Asp Glu Thr Val Arg Ala Glu Leu Gly 
65                  70                  75                  80  


Asp Ser Phe Gly Gly Ser Phe Tyr Asp Ala Asp Lys Gly Gly Leu Val 
                85                  90                  95      


Val Ser Val Thr Asp Pro Ala Gln Leu Arg Glu Ala Arg Ala Ala Gly 
            100                 105                 110         


Ala Glu Ala Arg Met Val Asp Asp Ser Ala Ala Glu Leu Glu Ala Ala 
        115                 120                 125             


Ala Asn Arg Leu Asn Arg Ala Glu Ser Arg Ala Pro Gly Ser Val Thr 
    130                 135                 140                 


Gly Trp Tyr Val Asp Val Glu Arg Asn Ser Val Val Val Thr Thr Thr 
145                 150                 155                 160 


Pro Gly Thr Ala Ala Gly Ala Glu Glu Phe Val Ala Ser Ala Gly Val 
                165                 170                 175     


Asp Ala Asp Thr Ala Glu Val Val Glu Ser Ala Glu Arg Pro Arg Ala 
            180                 185                 190         


Leu Met Asp Val Val Gly Gly Asn Ala Tyr Tyr Met Gly Ser Gly Gly 
        195                 200                 205             


Arg Cys Ser Val Gly Phe Ala Val Asn Gly Gly Phe Val Thr Ala Gly 
    210                 215                 220                 


His Cys Gly Ser Thr Gly Glu Ser Thr Ser Gln Pro Ser Gly Thr Phe 
225                 230                 235                 240 


Ala Gly Ser Ser Phe Pro Tyr Asn Asp Tyr Ala Tyr Val Glu Thr Gly 
                245                 250                 255     


Ser Asp Asp Thr Pro Arg Pro Tyr Val Asn Thr Tyr Ser Gly Thr Arg 
            260                 265                 270         


Thr Val Ser Gly Ser Asn Glu Ala Pro Val Gly Ser Ser Ile Cys Arg 
        275                 280                 285             


Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Val Glu Ala Lys Asn 
    290                 295                 300                 


Gln Thr Val Arg Tyr Ser Gln Gly Ala Val Tyr Gly Met Thr Arg Thr 
305                 310                 315                 320 


Asp Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Phe Ile Ser Gly 
                325                 330                 335     


Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser Gly Asn Cys Thr Trp 
            340                 345                 350         


Gly Gly Thr Thr Tyr Phe Gln Pro Val Asn Glu Ala Leu Asn Ala Tyr 
        355                 360                 365             


Gly Leu Ser Leu Val Thr Gly 
    370                 375 


<210>  11
<211>  380
<212>  PRT
<213>  Saccharomonospora paurometabolica

<400>  11

Met Thr Ser Arg Lys Arg Arg Val Ala Ala Arg Leu Gly Thr Thr Ala 
1               5                   10                  15      


Val Leu Ala Thr Gly Met Ala Ala Ala Leu Ala Ile Pro Ala Thr Ala 
            20                  25                  30          


Gly Ser Gly Ala Pro Val Thr Pro Ala Gly Asp Asn Asp Pro Met Ile 
        35                  40                  45              


Gln Ala Met Gln Arg Asp Leu Gly Val Asn Ala Ala Gln Ala Glu Gln 
    50                  55                  60                  


Arg Leu Arg Ala Glu Ala Glu Ala Arg Gly Val Ala Asp Thr Val Arg 
65                  70                  75                  80  


Ala Glu Leu Gly Asp Ser Phe Gly Gly Ala His Phe Asp Ala Glu Arg 
                85                  90                  95      


Asp Thr Leu Val Val Gly Val Thr Asp Ala Ala Lys Ala Asp Glu Val 
            100                 105                 110         


Arg Ala Ala Gly Ala Glu Ala Arg Met Val Asp Ala Ser Ser Ala Glu 
        115                 120                 125             


Leu Glu Ser Ile Thr Gln Arg Leu Asn Arg Ala Glu Asn Arg Ala Pro 
    130                 135                 140                 


Asp Ala Val Thr Gly Trp Tyr Val Asp Val Glu Ser Asn Ser Val Val 
145                 150                 155                 160 


Val Thr Thr Ala Pro Lys Thr Arg Gly Gln Ala Thr Ala Phe Val Asn 
                165                 170                 175     


Ser Thr Gly Ala Asp Arg Ser Gln Val Glu Val Val Glu Ser Arg Glu 
            180                 185                 190         


Gln Pro Arg Ala Leu Met Asn Ile Tyr Gly Gly Asn Ala Tyr Tyr Met 
        195                 200                 205             


Gly Ser Gly Gly Arg Cys Ser Ile Gly Phe Ala Val Asn Gly Gly Phe 
    210                 215                 220                 


Val Thr Ala Gly His Cys Gly Ser Thr Gly Glu Ser Thr Ser Gln Pro 
225                 230                 235                 240 


Ser Gly Thr Phe Ala Gly Ser Ser Phe Pro Tyr Asn Asp Tyr Ala Tyr 
                245                 250                 255     


Val Gln Thr Gly Ser Asp Asp Thr Pro Gln Pro Leu Val Asn Met Tyr 
            260                 265                 270         


Asn Gly Tyr Gly Arg Thr Val Ser Gly Ser Asn Glu Ala Pro Val Gly 
        275                 280                 285             


Ser Ser Ile Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr 
    290                 295                 300                 


Val Glu Ala Lys Asn Gln Thr Val Arg Tyr Ser Gln Gly Ala Val Tyr 
305                 310                 315                 320 


Gly Met Thr Arg Thr Asp Val Cys Ala Glu Pro Gly Asp Ser Gly Gly 
                325                 330                 335     


Ser Phe Ile Ser Gly Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser 
            340                 345                 350         


Gly Asn Cys Thr Trp Gly Gly Thr Thr Tyr Phe Gln Pro Val Asn Glu 
        355                 360                 365             


Ala Leu Asn Ala Tyr Gly Leu Ser Leu Val Thr Gly 
    370                 375                 380 


<210>  12
<211>  364
<212>  PRT
<213>  Saccharopolyspora erythraea

<400>  12

Ala Val Leu Ala Ala Gly Thr Ile Ala Ala Ile Gly Ala Pro Thr Val 
1               5                   10                  15      


Gly Ala Glu Pro Val Ser Pro Asp Leu Val Ala Ala Met Glu Arg Asp 
            20                  25                  30          


Leu Gly Ile Ser Ala Gln Gln Ala His Ala Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Thr Ala Met Arg Ala Asp Ala Glu Leu Ser Arg Ser Leu Gly Glu Ser 
    50                  55                  60                  


Phe Gly Gly Ser Tyr Phe Asp Ala Ala Arg Gly Lys Leu Val Val Gly 
65                  70                  75                  80  


Val Thr Glu Gln Ala Asp Ala Ala Lys Val Arg Ala Ala Gly Ala Glu 
                85                  90                  95      


Ala Ala Val Val Pro Asn Ser Leu Arg Glu Leu Asp Ala Thr Lys Ala 
            100                 105                 110         


Ala Leu Asp Ala Met Asp Ala Ala Ala Pro Ala Ser Val Thr Gly Trp 
        115                 120                 125             


Tyr Val Asp Val Pro Ser Ser Ser Val Val Val Ser Val Asn Gly Arg 
    130                 135                 140                 


Asp Ala Ala Thr Asp Ala Phe Leu Asp Lys Ala Lys Ala Ala Gly Asp 
145                 150                 155                 160 


Ser Val Arg Val Gln Glu Val Ala Glu Ser Pro Arg Pro Leu Tyr Asn 
                165                 170                 175     


Val Val Gly Gly Asp Ala Tyr Tyr Met Gly Gly Arg Cys Ser Val Gly 
            180                 185                 190         


Phe Ser Val Arg Ser Ser Ser Gly Gln Ala Gly Phe Val Thr Ala Gly 
        195                 200                 205             


His Cys Gly Thr Arg Gly Thr Ala Val Ser Gly Tyr Asn Gln Val Ala 
    210                 215                 220                 


Met Gly Ser Phe Gln Gly Ser Ser Phe Pro Asn Asn Asp Tyr Ala Trp 
225                 230                 235                 240 


Val Ser Val Asn Ser Asn Trp Thr Pro Gln Pro Trp Val Asn Leu Tyr 
                245                 250                 255     


Asn Gly Ser Ala Arg Val Val Ser Gly Ser Ser Ala Ala Pro Val Gly 
            260                 265                 270         


Ser Ser Ile Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Ser 
        275                 280                 285             


Val Gln Ala Leu Asn Gln Thr Val Arg Tyr Ala Glu Gly Thr Val Tyr 
    290                 295                 300                 


Gly Leu Thr Arg Thr Asn Val Cys Ala Glu Pro Gly Asp Ser Gly Gly 
305                 310                 315                 320 


Ser Phe Ile Ser Gly Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser 
                325                 330                 335     


Gly Asn Cys Ser Ser Gly Gly Thr Thr Tyr Phe Gln Pro Val Asn Glu 
            340                 345                 350         


Ala Leu Ser Ala Tyr Gly Leu Ser Leu Val Arg Gly 
        355                 360                 


<210>  13
<211>  378
<212>  PRT
<213>  Saccharomonospora xinjiangensis XJ-54

<400>  13

Met Asn Arg Lys Asn Ala Ala Arg Leu Ile Ala Ser Val Thr Leu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Val Ala Phe Thr Leu Pro Ala Thr Ala Ala Pro Ala 
            20                  25                  30          


Ala Asp Ala Val Val Pro Ala Thr Ala Ala Asp Pro Val Val Gln Ala 
        35                  40                  45              


Met Gln Arg Asp Leu Gly Leu Thr Lys Gln Glu Ala Glu Gln Arg Leu 
    50                  55                  60                  


Arg Ser Glu Ala Glu Ala Arg Glu Val His Glu Thr Val Ser Glu Arg 
65                  70                  75                  80  


Leu Gly Ser Asp Phe Ala Gly Ala His Tyr Asp Ala Glu Arg Gly Thr 
                85                  90                  95      


Leu Val Val Gly Val Thr Asp Ala Ala Glu Phe Ser Glu Val Arg Glu 
            100                 105                 110         


Ala Gly Ala Thr Pro Arg Leu Val Glu His Thr Val Ala Asp Leu Glu 
        115                 120                 125             


Ser Ala Ala Glu Lys Leu Asp Ala Lys Glu Ser Arg Ala Pro Glu Ser 
    130                 135                 140                 


Val Thr Gly Trp Tyr Val Asp Ile Glu Ala Asn Ser Val Val Val Thr 
145                 150                 155                 160 


Thr Lys Pro Gly Thr Ala Gly Gln Ala Glu Arg Phe Val Ser Arg Ala 
                165                 170                 175     


Gly Val Asp Ala Asp Ala Val Asp Val Val Glu Ser Lys Glu Ser Pro 
            180                 185                 190         


Arg Ala Leu Met Asp Ile Ile Gly Gly Asn Ala Tyr Tyr Met Gly Ser 
        195                 200                 205             


Gly Gly Arg Cys Ser Val Gly Phe Ser Val Gln Gly Gly Phe Val Thr 
    210                 215                 220                 


Ala Gly His Cys Gly Thr Thr Gly Thr Thr Thr Ser Ser Pro Thr Gly 
225                 230                 235                 240 


Arg Phe Ala Gly Ser Ser Phe Pro Gly Asn Asp Tyr Ala Phe Val Arg 
                245                 250                 255     


Thr Gly Ser Gly Asp Thr Leu Arg Pro Trp Val Asn Met Tyr Asn Gly 
            260                 265                 270         


Ser Ala Arg Val Val Ser Gly Ser Ser Glu Ala Pro Val Gly Ser Ser 
        275                 280                 285             


Ile Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Val Glu 
    290                 295                 300                 


Ala Lys Asn Gln Thr Val Arg Tyr Pro Gln Gly Thr Val Tyr Gly Leu 
305                 310                 315                 320 


Thr Arg Thr Asn Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Phe 
                325                 330                 335     


Ile Ser Gly Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser Gly Asn 
            340                 345                 350         


Cys Thr Trp Gly Gly Thr Thr Tyr Phe Gln Pro Val Asn Glu Val Leu 
        355                 360                 365             


Asn Ala Tyr Gly Leu Arg Leu Ile Thr Gly 
    370                 375             


<210>  14
<211>  378
<212>  PRT
<213>  Saccharomonospora azurea NA-128

<400>  14

Met Asn Arg Lys Ser Ala Val Arg Val Leu Ala Ser Val Thr Met Ala 
1               5                   10                  15      


Ala Gly Thr Ala Val Ala Phe Thr Leu Pro Ala Thr Ala Ala Pro Ala 
            20                  25                  30          


Asp Val Ser Val Val Pro Thr Thr Glu Ala Asp Pro Val Val Gln Ala 
        35                  40                  45              


Met Gln Arg Asp Leu Gly Leu Thr Lys Ala Gln Ala Glu Gln Arg Leu 
    50                  55                  60                  


Gln Asp Glu Ala Glu Ala Arg Glu Val His Glu Thr Val Thr Ala Lys 
65                  70                  75                  80  


Leu Gly Ala Glu Tyr Ala Gly Ala His Tyr Asp Ala Asp Arg Gly Thr 
                85                  90                  95      


Leu Val Val Gly Val Thr Asp Ala Ala Glu Phe Asp Ala Val Lys Ala 
            100                 105                 110         


Ala Gly Ala Thr Pro Arg Leu Val Glu Tyr Thr Val Thr Glu Leu Glu 
        115                 120                 125             


Ser Ala Ala Ala Lys Leu Asp Ala Lys Glu Ser Ala Ala Pro Glu Ala 
    130                 135                 140                 


Val Thr Gly Trp Tyr Val Asp Ile Glu Ala Asn Ser Ile Val Val Thr 
145                 150                 155                 160 


Thr Ala Pro Gly Thr Ala Ala Lys Ala Glu Arg Phe Val Asp Arg Ala 
                165                 170                 175     


Gly Val Asp Ala Asp Ala Val Asp Val Val Glu Ser Lys Glu Ser Pro 
            180                 185                 190         


Gln Ala Leu Met Asp Ile Ile Gly Gly Asn Ala Tyr Tyr Met Gly Asn 
        195                 200                 205             


Gly Gly Arg Cys Ser Val Gly Phe Ala Val Gln Gly Gly Phe Val Thr 
    210                 215                 220                 


Ala Gly His Cys Gly Thr Thr Gly Thr Ser Thr Ser Ser Pro Thr Gly 
225                 230                 235                 240 


Arg Phe Ala Gly Ser Ser Phe Pro Gly Asn Asp Tyr Ala Tyr Val Gln 
                245                 250                 255     


Thr Gly Ser Gly Asp Thr Leu Arg Pro Trp Val Asn Met Tyr Asn Gly 
            260                 265                 270         


Ser Ala Arg Val Val Ser Gly Ser Ser Glu Ala Pro Val Gly Ser Ser 
        275                 280                 285             


Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Glu 
    290                 295                 300                 


Ala Lys Asn Gln Thr Val Arg Tyr Ala Glu Gly Ser Val Ser Gly Leu 
305                 310                 315                 320 


Val Arg Thr Asn Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Phe 
                325                 330                 335     


Ile Ala Gly Asn Gln Ala Gln Gly Met Thr Ser Gly Gly Ser Gly Asn 
            340                 345                 350         


Cys Thr Trp Gly Gly Thr Thr Tyr Tyr Gln Pro Val Asn Glu Val Leu 
        355                 360                 365             


Ser Ala Tyr Gly Leu Arg Leu Ile Thr Gly 
    370                 375             


