                         SEQUENCE LISTING

<110>  GENCIA CORPORATION
       KHAN, SHAHARYAR
 
<120>  METHODS OF MITIGATING SIDE EFFECTS OF RADIATION EXPOSURE AND 
       CHEMOTHERAPY

<130>  GNC 0015

<150>  61/660,228
<151>  2012-06-15

<150>  61/701,313
<151>  2012-09-14

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Phe Leu Arg Ser Met Trp Gly Val Leu Ser Ala Leu Gly Arg 
1               5                   10                  15      


Ser Gly Ala Glu Leu Cys Thr Gly Cys Gly Ser Arg Leu Arg Ser Pro 
            20                  25                  30          


Phe Ser Phe Val Tyr Leu Pro Arg Trp Phe Ser Ser Val Leu Ala Ser 
        35                  40                  45              


Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys Glu Gln 
    50                  55                  60                  


Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr Glu Leu 
65                  70                  75                  80  


Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser Lys Lys 
                85                  90                  95      


Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr Lys Glu 
            100                 105                 110         


Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile Met Ser 
        115                 120                 125             


Leu Glu Lys Glu Ile Met Asp Lys His Leu Lys Arg Lys Ala Met Thr 
    130                 135                 140                 


Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro Arg Ser 
145                 150                 155                 160 


Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys Gly Asp 
                165                 170                 175     


Ser Pro Gln Glu Lys Leu Lys Thr Val Lys Glu Asn Trp Lys Asn Leu 
            180                 185                 190         


Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln His Ala Lys Glu Asp Glu 
        195                 200                 205             


Thr Arg Tyr His Asn Glu Met Lys Ser Trp Glu Glu Gln Met Ile Glu 
    210                 215                 220                 


Val Gly Arg Lys Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln Arg Lys 
225                 230                 235                 240 


Tyr Gly Ala Glu Glu Cys 
                245     


<210>  2
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Phe Leu Arg Ser Met Trp Gly Val Leu Ser Ala Leu Gly Arg 
1               5                   10                  15      


Ser Gly Ala Glu Leu Cys Thr Gly Cys Gly Ser Arg Leu Arg Ser Pro 
            20                  25                  30          


Phe Ser Phe Val Tyr Leu Pro Arg Trp Phe 
        35                  40          


<210>  3
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Ser Val Leu Ala Ser Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu 
1               5                   10                  15      


Arg Phe Ser Lys Glu Gln Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp 
            20                  25                  30          


Ala Lys Thr Thr Glu Leu Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu 
        35                  40                  45              


Leu Pro Asp Ser Lys Lys Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu 
    50                  55                  60                  


Trp Gln Val Tyr Lys Glu Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr 
65                  70                  75                  80  


Pro Ser Gln Ile Met Ser Leu Glu Lys Glu Ile Met Asp Lys His Leu 
                85                  90                  95      


Lys Arg Lys Ala Met Thr Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys 
            100                 105                 110         


Pro Lys Arg Pro Arg Ser Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe 
        115                 120                 125             


Gln Glu Ala Lys Gly Asp Ser Pro Gln Glu Lys Leu Lys Thr Val Lys 
    130                 135                 140                 


Glu Asn Trp Lys Asn Leu Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln 
145                 150                 155                 160 


His Ala Lys Glu Asp Glu Thr Arg Tyr His Asn Glu Met Lys Ser Trp 
                165                 170                 175     


Glu Glu Gln Met Ile Glu Val Gly Arg Lys Asp Leu Leu Arg Arg Thr 
            180                 185                 190         


Ile Lys Lys Gln Arg Lys Tyr Gly Ala Glu Glu Cys 
        195                 200                 


<210>  4
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ser Gly Lys Leu Ser Thr Cys Arg Leu Pro Pro Leu Pro 
1               5                   10                  15      


Thr Ile Arg Glu Ile Ile Lys Leu Leu Arg Leu Gln Ala Ala Asn Glu 
            20                  25                  30          


Leu Ser Gln Asn Phe Leu Leu Asp Leu Arg Leu Thr Asp Lys Ile Val 
        35                  40                  45              


Arg Lys Ala Gly Asn Leu Thr Asn Ala Tyr Val Tyr Glu Val Gly Pro 
    50                  55                  60                  


Gly Pro Gly Gly Ile Thr Arg Ser Ile Leu Asn Ala Asp Val Ala Glu 
65                  70                  75                  80  


Leu Leu Val Val Glu Lys Asp Thr Arg Phe Ile Pro Gly Leu Gln Met 
                85                  90                  95      


Leu Ser Asp Ala Ala Pro Gly Lys Leu Arg Ile Val His Gly Asp Val 
            100                 105                 110         


Leu Thr Phe Lys Val Glu Lys Ala Phe Ser Glu Ser Leu Lys Arg Pro 
        115                 120                 125             


Trp Glu Asp Asp Pro Pro Asn Val His Ile Ile Gly Asn Leu Pro Phe 
    130                 135                 140                 


Ser Val Ser Thr Pro Leu Ile Ile Lys Trp Leu Glu Asn Ile Ser Cys 
145                 150                 155                 160 


Arg Asp Gly Pro Phe Val Tyr Gly Arg Thr Gln Met Thr Leu Thr Phe 
                165                 170                 175     


Gln Lys Glu Val Ala Glu Arg Leu Ala Ala Asn Thr Gly Ser Lys Gln 
            180                 185                 190         


Arg Ser Arg Leu Ser Val Met Ala Gln Tyr Leu Cys Asn Val Arg His 
        195                 200                 205             


Ile Phe Thr Ile Pro Gly Gln Ala Phe Val Pro Lys Pro Glu Val Asp 
    210                 215                 220                 


Val Gly Val Val His Phe Thr Pro Leu Ile Gln Pro Lys Ile Glu Gln 
225                 230                 235                 240 


Pro Phe Lys Leu Val Glu Lys Val Val Gln Asn Val Phe Gln Phe Arg 
                245                 250                 255     


Arg Lys Tyr Cys His Arg Gly Leu Arg Met Leu Phe Pro Glu Ala Gln 
            260                 265                 270         


Arg Leu Glu Ser Thr Gly Arg Leu Leu Glu Leu Ala Asp Ile Asp Pro 
        275                 280                 285             


Thr Leu Arg Pro Arg Gln Leu Ser Ile Ser His Phe Lys Ser Leu Cys 
    290                 295                 300                 


Asp Val Tyr Arg Lys Met Cys Asp Glu Asp Pro Gln Leu Phe Ala Tyr 
305                 310                 315                 320 


Asn Phe Arg Glu Glu Leu Lys Arg Arg Lys Ser Lys Asn Glu Glu Lys 
                325                 330                 335     


Glu Glu Asp Asp Ala Glu Asn Tyr Arg Leu 
            340                 345     


<210>  5
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Trp Ile Pro Val Val Gly Leu Pro Arg Arg Leu Arg Leu Ser Ala 
1               5                   10                  15      


Leu Ala Gly Ala Gly Arg Phe Cys Ile Leu Gly Ser Glu Ala Ala Thr 
            20                  25                  30          


Arg Lys His Leu Pro Ala Arg Asn His Cys Gly Leu Ser Asp Ser Ser 
        35                  40                  45              


Pro Gln Leu Trp Pro Glu Pro Asp Phe Arg Asn Pro Pro Arg Lys Ala 
    50                  55                  60                  


Ser Lys Ala Ser Leu Asp Phe Lys Arg Tyr Val Thr Asp Arg Arg Leu 
65                  70                  75                  80  


Ala Glu Thr Leu Ala Gln Ile Tyr Leu Gly Lys Pro Ser Arg Pro Pro 
                85                  90                  95      


His Leu Leu Leu Glu Cys Asn Pro Gly Pro Gly Ile Leu Thr Gln Ala 
            100                 105                 110         


Leu Leu Glu Ala Gly Ala Lys Val Val Ala Leu Glu Ser Asp Lys Thr 
        115                 120                 125             


Phe Ile Pro His Leu Glu Ser Leu Gly Lys Asn Leu Asp Gly Lys Leu 
    130                 135                 140                 


Arg Val Ile His Cys Asp Phe Phe Lys Leu Asp Pro Arg Ser Gly Gly 
145                 150                 155                 160 


Val Ile Lys Pro Pro Ala Met Ser Ser Arg Gly Leu Phe Lys Asn Leu 
                165                 170                 175     


Gly Ile Glu Ala Val Pro Trp Thr Ala Asp Ile Pro Leu Lys Val Val 
            180                 185                 190         


Gly Met Phe Pro Ser Arg Gly Glu Lys Arg Ala Leu Trp Lys Leu Ala 
        195                 200                 205             


Tyr Asp Leu Tyr Ser Cys Thr Ser Ile Tyr Lys Phe Gly Arg Ile Glu 
    210                 215                 220                 


Val Asn Met Phe Ile Gly Glu Lys Glu Phe Gln Lys Leu Met Ala Asp 
225                 230                 235                 240 


Pro Gly Asn Pro Asp Leu Tyr His Val Leu Ser Val Ile Trp Gln Leu 
                245                 250                 255     


Ala Cys Glu Ile Lys Val Leu His Met Glu Pro Trp Ser Ser Phe Asp 
            260                 265                 270         


Ile Tyr Thr Arg Lys Gly Pro Leu Glu Asn Pro Lys Arg Arg Glu Leu 
        275                 280                 285             


Leu Asp Gln Leu Gln Gln Lys Leu Tyr Leu Ile Gln Met Ile Pro Arg 
    290                 295                 300                 


Gln Asn Leu Phe Thr Lys Asn Leu Thr Pro Met Asn Tyr Asn Ile Phe 
305                 310                 315                 320 


Phe His Leu Leu Lys His Cys Phe Gly Arg Arg Ser Ala Thr Val Ile 
                325                 330                 335     


Asp His Leu Arg Ser Leu Thr Pro Leu Asp Ala Arg Asp Ile Leu Met 
            340                 345                 350         


Gln Ile Gly Lys Gln Glu Asp Glu Lys Val Val Asn Met His Pro Gln 
        355                 360                 365             


Asp Phe Lys Thr Leu Phe Glu Thr Ile Glu Arg Ser Lys Asp Cys Ala 
    370                 375                 380                 


Tyr Lys Trp Leu Tyr Asp Glu Thr Leu Glu Asp Arg 
385                 390                 395     


<210>  6
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct - DNA-binding site of SOX9

<400>  6
agaacaatgg                                                              10


<210>  7
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide - a TAT protein transduction domain

<400>  7

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  8
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a protein transduction domain

<400>  8

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polypeptide - a protein transduction domain

<400>  9

Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210>  10
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a protein tranduction domain

<400>  10

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  11
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a protein transduction domain

<400>  11

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  12
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  synethtic polypeptide - a protein transduction domain

<400>  12

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu Ala 
            20                  25                  


<210>  13
<211>  16
<212>  PRT
<213>  artificial polypeptide

<220>
<223>  synthetic polypeptide - a protein transduction domain

<400>  13

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  14
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - an endosomal escape sequence

<400>  14

Gly Asp Ile Met Gly Glu Trp Gly Asn Glu Ile Phe Gly Ala Ile Ala 
1               5                   10                  15      


Gly Phe Leu Gly 
            20  


<210>  15
<211>  35
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a protein transduction domain including 
       an endosomal escape sequence

<400>  15

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Gly Glu Gly Asp Ile 
1               5                   10                  15      


Met Gly Glu Trp Gly Asn Glu Ile Phe Gly Ala Ile Ala Gly Phe Leu 
            20                  25                  30          


Gly Gly Glu 
        35  


<210>  16
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - predicted sequence from Etfa

<400>  16

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
1               5                   10                  15      


Leu Arg Phe 
            


<210>  17
<211>  35
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - predicted mitochondrial targeting signal 
       from Dld

<400>  17

Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His 
1               5                   10                  15      


Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu 
            20                  25                  30          


Arg Thr Tyr 
        35  


<210>  18
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a mitochondrial localization signal

<400>  18

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Pro Pro Val 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln 
            20                  


<210>  19
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a mitochondrial localization signal

<400>  19

Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Pro Pro Val Leu 
1               5                   10                  15      


Gly Tyr Leu Gly Ser Arg Gln 
            20              


<210>  20
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a mitochondrial localization signal

<400>  20

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Val 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln 
            20                  


<210>  21
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a mitochondrial localization signal

<400>  21

Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Val Leu 
1               5                   10                  15      


Gly Tyr Leu Gly Ser Arg Gln 
            20              


<210>  22
<211>  259
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - recombinant fusion protein

<400>  22

Met Ala Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Met Ala Phe 
1               5                   10                  15      


Leu Arg Ser Met Trp Gly Val Leu Ser Ala Leu Gly Arg Ser Gly Ala 
            20                  25                  30          


Glu Leu Cys Thr Gly Cys Gly Ser Arg Leu Arg Ser Pro Phe Ser Phe 
        35                  40                  45              


Val Tyr Leu Pro Arg Trp Phe Ser Ser Val Leu Ala Ser Cys Pro Lys 
    50                  55                  60                  


Lys Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys Glu Gln Leu Pro Ile 
65                  70                  75                  80  


Phe Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr Glu Leu Ile Arg Arg 
                85                  90                  95      


Ile Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser Lys Lys Lys Ile Tyr 
            100                 105                 110         


Gln Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr Lys Glu Glu Ile Ser 
        115                 120                 125             


Arg Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile Met Ser Leu Glu Lys 
    130                 135                 140                 


Glu Ile Met Asp Lys His Leu Lys Arg Lys Ala Met Thr Lys Lys Lys 
145                 150                 155                 160 


Glu Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro Arg Ser Ala Tyr Asn 
                165                 170                 175     


Val Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys Gly Asp Ser Pro Gln 
            180                 185                 190         


Glu Lys Leu Lys Thr Val Lys Glu Asn Trp Lys Asn Leu Ser Asp Ser 
        195                 200                 205             


Glu Lys Glu Leu Tyr Ile Gln His Ala Lys Glu Asp Glu Thr Arg Tyr 
    210                 215                 220                 


His Asn Glu Met Lys Ser Trp Glu Glu Gln Met Ile Glu Val Gly Arg 
225                 230                 235                 240 


Lys Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln Arg Lys Tyr Gly Ala 
                245                 250                 255     


Glu Glu Cys 
            


<210>  23
<211>  258
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - recombinant fusion protein

<400>  23

Ala Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Met Ala Phe Leu 
1               5                   10                  15      


Arg Ser Met Trp Gly Val Leu Ser Ala Leu Gly Arg Ser Gly Ala Glu 
            20                  25                  30          


Leu Cys Thr Gly Cys Gly Ser Arg Leu Arg Ser Pro Phe Ser Phe Val 
        35                  40                  45              


Tyr Leu Pro Arg Trp Phe Ser Ser Val Leu Ala Ser Cys Pro Lys Lys 
    50                  55                  60                  


Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys Glu Gln Leu Pro Ile Phe 
65                  70                  75                  80  


Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr Glu Leu Ile Arg Arg Ile 
                85                  90                  95      


Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser Lys Lys Lys Ile Tyr Gln 
            100                 105                 110         


Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr Lys Glu Glu Ile Ser Arg 
        115                 120                 125             


Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile Met Ser Leu Glu Lys Glu 
    130                 135                 140                 


Ile Met Asp Lys His Leu Lys Arg Lys Ala Met Thr Lys Lys Lys Glu 
145                 150                 155                 160 


Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro Arg Ser Ala Tyr Asn Val 
                165                 170                 175     


Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys Gly Asp Ser Pro Gln Glu 
            180                 185                 190         


Lys Leu Lys Thr Val Lys Glu Asn Trp Lys Asn Leu Ser Asp Ser Glu 
        195                 200                 205             


Lys Glu Leu Tyr Ile Gln His Ala Lys Glu Asp Glu Thr Arg Tyr His 
    210                 215                 220                 


Asn Glu Met Lys Ser Trp Glu Glu Gln Met Ile Glu Val Gly Arg Lys 
225                 230                 235                 240 


Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln Arg Lys Tyr Gly Ala Glu 
                245                 250                 255     


Glu Cys 
        


<210>  24
<211>  780
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide - nucleic acid encoding a recombinant 
       fusion protein

<400>  24
atggcgcgtc gtcgtcgtcg tcgtcgtcgt cgtcgtcgta tggcgtttct ccgaagcatg       60

tggggcgtgc tgagtgccct gggaaggtct ggagcagagc tgtgcaccgg ctgtggaagt      120

cgactgcgct cccccttcag ttttgtgtat ttaccgaggt ggttttcatc tgtcttggca      180

agttgtccaa agaaacctgt aagttcttac cttcgatttt ctaaagaaca actacccata      240

tttaaagctc agaacccaga tgcaaaaact acagaactaa ttagaagaat tgcccagcgt      300

tggagggaac ttcctgattc aaagaaaaaa atatatcaag atgcttatag ggcggagtgg      360

caggtatata aagaagagat aagcagattt aaagaacagc taactccaag tcagattatg      420

tctttggaaa aagaaatcat ggacaaacat ttaaaaagga aagctatgac aaaaaaaaaa      480

gagttaacac tgcttggaaa accaaaaaga cctcgttcag cttataacgt ttatgtagct      540

gaaagattcc aagaagctaa gggtgattca ccgcaggaaa agctgaagac tgtaaaggaa      600

aactggaaaa atctgtctga ctctgaaaag gaattatata ttcagcatgc taaagaggac      660

gaaactcgtt atcataatga aatgaagtct tgggaagaac aaatgattga agttggacga      720

aaggatcttc tacgtcgcac aataaagaaa caacgaaaat atggtgctga ggagtgttaa      780


<210>  25
<211>  264
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - recombinant fusion protein

<400>  25

Met Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Gly Glu Gly Asp 
1               5                   10                  15      


Ile Met Gly Glu Trp Gly Asn Glu Ile Phe Gly Ala Ile Ala Gly Phe 
            20                  25                  30          


Leu Gly Gly Glu Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln 
        35                  40                  45              


Leu Pro Pro Val Leu Gly Tyr Leu Gly Ser Arg Gln Ser Ser Val Leu 
    50                  55                  60                  


Ala Ser Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys 
65                  70                  75                  80  


Glu Gln Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr 
                85                  90                  95      


Glu Leu Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser 
            100                 105                 110         


Lys Lys Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr 
        115                 120                 125             


Lys Glu Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile 
    130                 135                 140                 


Met Ser Leu Glu Lys Glu Ile Met Asp Lys His Leu Lys Arg Lys Ala 
145                 150                 155                 160 


Met Thr Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro 
                165                 170                 175     


Arg Ser Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys 
            180                 185                 190         


Gly Asp Ser Pro Gln Glu Lys Leu Lys Thr Val Lys Glu Asn Trp Lys 
        195                 200                 205             


Asn Leu Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln His Ala Lys Glu 
    210                 215                 220                 


Asp Glu Thr Arg Tyr His Asn Glu Met Lys Ser Trp Glu Glu Gln Met 
225                 230                 235                 240 


Ile Glu Val Gly Arg Lys Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln 
                245                 250                 255     


Arg Lys Tyr Gly Ala Glu Glu Cys 
            260                 


<210>  26
<211>  263
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - recombinant fusion protein

<400>  26

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Gly Glu Gly Asp Ile 
1               5                   10                  15      


Met Gly Glu Trp Gly Asn Glu Ile Phe Gly Ala Ile Ala Gly Phe Leu 
            20                  25                  30          


Gly Gly Glu Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu 
        35                  40                  45              


Pro Pro Val Leu Gly Tyr Leu Gly Ser Arg Gln Ser Ser Val Leu Ala 
    50                  55                  60                  


Ser Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys Glu 
65                  70                  75                  80  


Gln Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr Glu 
                85                  90                  95      


Leu Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser Lys 
            100                 105                 110         


Lys Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr Lys 
        115                 120                 125             


Glu Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile Met 
    130                 135                 140                 


Ser Leu Glu Lys Glu Ile Met Asp Lys His Leu Lys Arg Lys Ala Met 
145                 150                 155                 160 


Thr Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro Arg 
                165                 170                 175     


Ser Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys Gly 
            180                 185                 190         


Asp Ser Pro Gln Glu Lys Leu Lys Thr Val Lys Glu Asn Trp Lys Asn 
        195                 200                 205             


Leu Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln His Ala Lys Glu Asp 
    210                 215                 220                 


Glu Thr Arg Tyr His Asn Glu Met Lys Ser Trp Glu Glu Gln Met Ile 
225                 230                 235                 240 


Glu Val Gly Arg Lys Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln Arg 
                245                 250                 255     


Lys Tyr Gly Ala Glu Glu Cys 
            260             


<210>  27
<211>  795
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - nucleic acid encoding a recombinant 
       fusion protein

<400>  27
atgcggcgac gcagacgtcg tcgtcggcgg cgtcgcggcg agggtgatat tatgggtgaa       60

tgggggaacg aaattttcgg agcgatcgct ggttttctcg gtggagaaat gttatcacgc      120

gcggtatgtg gcaccagcag gcagctgcct ccagtccttg gctatctggg ttcccgccag      180

tcatcggtgt tagcatcatg tccgaaaaaa cctgtctcgt cgtacctgcg cttctccaaa      240

gagcagctgc cgatttttaa agcgcaaaat ccggatgcta aaacgactga actgattcgc      300

cgcattgcac aacgctggcg cgaactcccg gacagtaaaa aaaaaattta tcaggacgcc      360

tatcgggctg aatggcaggt ctataaagag gagatctcac gcttcaaaga acaattaacc      420

ccgagtcaaa taatgtctct ggaaaaagaa atcatggata aacacttaaa acgaaaggcg      480

atgacgaaga aaaaagaact gaccctgcta ggtaaaccta agcgtccgcg ctctgcgtat      540

aatgtgtacg tggcagaacg ttttcaggag gccaaagggg attctccgca agaaaaactg      600

aagaccgtca aagaaaattg gaaaaacctg tctgatagcg aaaaagaact gtacattcag      660

cacgctaaag aagatgagac gcggtatcac aacgaaatga aatcttggga agagcagatg      720

atcgaggtcg gtcggaagga tcttctccgt cgaaccatca aaaaacagcg taaatatgga      780

gcagaagagt gctga                                                       795


<210>  28
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a nuclear localization signal

<400>  28

Gly Lys Lys Arg Ser Lys Val 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a nuclear localization signal

<400>  29

Lys Ser Arg Lys Arg Lys Leu 
1               5           


<210>  30
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a nuclear localization signal

<400>  30

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Asp Lys 
            


<210>  31
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a nuclear localization signal

<400>  31

Arg Lys Lys Arg Lys Thr Glu Glu Glu Ser Pro Leu Lys Asp Lys Ala 
1               5                   10                  15      


Lys Lys Ser Lys 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a nuclear localization signal

<400>  32

Lys Asp Cys Val Met Asn Lys His His Arg Asn Arg Cys Gln Tyr Cys 
1               5                   10                  15      


Arg Leu Gln Arg 
            20  


<210>  33
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a nuclear localization signal

<400>  33

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  34
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a nuclear localization signal

<400>  34

Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210>  35
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - protein purification tag

<400>  35

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  36
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - protein purification tag

<400>  36

Tyr Pro Tyr Asp Val Pro 
1               5       


<210>  37
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - protein purification tag

<400>  37

Ile Leu Lys Lys Ala Thr Ala Tyr Ile Leu 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - protein purification tag

<400>  38

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  39
<211>  1230
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Ala Leu Cys Trp Gly Arg Gly Ala Ala Gly Leu Lys Arg Ala 
1               5                   10                  15      


Leu Arg Pro Cys Gly Arg Pro Gly Leu Pro Gly Lys Glu Gly Thr Ala 
            20                  25                  30          


Gly Gly Val Cys Gly Pro Arg Arg Ser Ser Ser Ala Ser Pro Gln Glu 
        35                  40                  45              


Gln Asp Gln Asp Arg Arg Lys Asp Trp Gly His Val Glu Leu Leu Glu 
    50                  55                  60                  


Val Leu Gln Ala Arg Val Arg Gln Leu Gln Ala Glu Ser Val Ser Glu 
65                  70                  75                  80  


Val Val Val Asn Arg Val Asp Val Ala Arg Leu Pro Glu Cys Gly Ser 
                85                  90                  95      


Gly Asp Gly Ser Leu Gln Pro Pro Arg Lys Val Gln Met Gly Ala Lys 
            100                 105                 110         


Asp Ala Thr Pro Val Pro Cys Gly Arg Trp Ala Lys Ile Leu Glu Lys 
        115                 120                 125             


Asp Lys Arg Thr Gln Gln Met Arg Met Gln Arg Leu Lys Ala Lys Leu 
    130                 135                 140                 


Gln Met Pro Phe Gln Ser Gly Glu Phe Lys Ala Leu Thr Arg Arg Leu 
145                 150                 155                 160 


Gln Val Glu Pro Arg Leu Leu Ser Lys Gln Met Ala Gly Cys Leu Glu 
                165                 170                 175     


Asp Cys Thr Arg Gln Ala Pro Glu Ser Pro Trp Glu Glu Gln Leu Ala 
            180                 185                 190         


Arg Leu Leu Gln Glu Ala Pro Gly Lys Leu Ser Leu Asp Val Glu Gln 
        195                 200                 205             


Ala Pro Ser Gly Gln His Ser Gln Ala Gln Leu Ser Gly Gln Gln Gln 
    210                 215                 220                 


Arg Leu Leu Ala Phe Phe Lys Cys Cys Leu Leu Thr Asp Gln Leu Pro 
225                 230                 235                 240 


Leu Ala His His Leu Leu Val Val His His Gly Gln Arg Gln Lys Arg 
                245                 250                 255     


Lys Leu Leu Thr Leu Asp Met Tyr Asn Ala Val Met Leu Gly Trp Ala 
            260                 265                 270         


Arg Gln Gly Ala Phe Lys Glu Leu Val Tyr Val Leu Phe Met Val Lys 
        275                 280                 285             


Asp Ala Gly Leu Thr Pro Asp Leu Leu Ser Tyr Ala Ala Ala Leu Gln 
    290                 295                 300                 


Cys Met Gly Arg Gln Asp Gln Asp Ala Gly Thr Ile Glu Arg Cys Leu 
305                 310                 315                 320 


Glu Gln Met Ser Gln Glu Gly Leu Lys Leu Gln Ala Leu Phe Thr Ala 
                325                 330                 335     


Val Leu Leu Ser Glu Glu Asp Arg Ala Thr Val Leu Lys Ala Val His 
            340                 345                 350         


Lys Val Lys Pro Thr Phe Ser Leu Pro Pro Gln Leu Pro Pro Pro Val 
        355                 360                 365             


Asn Thr Ser Lys Leu Leu Arg Asp Val Tyr Ala Lys Asp Gly Arg Val 
    370                 375                 380                 


Ser Tyr Pro Lys Leu His Leu Pro Leu Lys Thr Leu Gln Cys Leu Phe 
385                 390                 395                 400 


Glu Lys Gln Leu His Met Glu Leu Ala Ser Arg Val Cys Val Val Ser 
                405                 410                 415     


Val Glu Lys Pro Thr Leu Pro Ser Lys Glu Val Lys His Ala Arg Lys 
            420                 425                 430         


Thr Leu Lys Thr Leu Arg Asp Gln Trp Glu Lys Ala Leu Cys Arg Ala 
        435                 440                 445             


Leu Arg Glu Thr Lys Asn Arg Leu Glu Arg Glu Val Tyr Glu Gly Arg 
    450                 455                 460                 


Phe Ser Leu Tyr Pro Phe Leu Cys Leu Leu Asp Glu Arg Glu Val Val 
465                 470                 475                 480 


Arg Met Leu Leu Gln Val Leu Gln Ala Leu Pro Ala Gln Gly Glu Ser 
                485                 490                 495     


Phe Thr Thr Leu Ala Arg Glu Leu Ser Ala Arg Thr Phe Ser Arg His 
            500                 505                 510         


Val Val Gln Arg Gln Arg Val Ser Gly Gln Val Gln Ala Leu Gln Asn 
        515                 520                 525             


His Tyr Arg Lys Tyr Leu Cys Leu Leu Ala Ser Asp Ala Glu Val Pro 
    530                 535                 540                 


Glu Pro Cys Leu Pro Arg Gln Tyr Trp Glu Glu Leu Gly Ala Pro Glu 
545                 550                 555                 560 


Ala Leu Arg Glu Gln Pro Trp Pro Leu Pro Val Gln Met Glu Leu Gly 
                565                 570                 575     


Lys Leu Leu Ala Glu Met Leu Val Gln Ala Thr Gln Met Pro Cys Ser 
            580                 585                 590         


Leu Asp Lys Pro His Arg Ser Ser Arg Leu Val Pro Val Leu Tyr His 
        595                 600                 605             


Val Tyr Ser Phe Arg Asn Val Gln Gln Ile Gly Ile Leu Lys Pro His 
    610                 615                 620                 


Pro Ala Tyr Val Gln Leu Leu Glu Lys Ala Ala Glu Pro Thr Leu Thr 
625                 630                 635                 640 


Phe Glu Ala Val Asp Val Pro Met Leu Cys Pro Pro Leu Pro Trp Thr 
                645                 650                 655     


Ser Pro His Ser Gly Ala Phe Leu Leu Ser Pro Thr Lys Leu Met Arg 
            660                 665                 670         


Thr Val Glu Gly Ala Thr Gln His Gln Glu Leu Leu Glu Thr Cys Pro 
        675                 680                 685             


Pro Thr Ala Leu His Gly Ala Leu Asp Ala Leu Thr Gln Leu Gly Asn 
    690                 695                 700                 


Cys Ala Trp Arg Val Asn Gly Arg Val Leu Asp Leu Val Leu Gln Leu 
705                 710                 715                 720 


Phe Gln Ala Lys Gly Cys Pro Gln Leu Gly Val Pro Ala Pro Pro Ser 
                725                 730                 735     


Glu Ala Pro Gln Pro Pro Glu Ala His Leu Pro His Ser Ala Ala Pro 
            740                 745                 750         


Ala Arg Lys Ala Glu Leu Arg Arg Glu Leu Ala His Cys Gln Lys Val 
        755                 760                 765             


Ala Arg Glu Met His Ser Leu Arg Ala Glu Ala Leu Tyr Arg Leu Ser 
    770                 775                 780                 


Leu Ala Gln His Leu Arg Asp Arg Val Phe Trp Leu Pro His Asn Met 
785                 790                 795                 800 


Asp Phe Arg Gly Arg Thr Tyr Pro Cys Pro Pro His Phe Asn His Leu 
                805                 810                 815     


Gly Ser Asp Val Ala Arg Ala Leu Leu Glu Phe Ala Gln Gly Arg Pro 
            820                 825                 830         


Leu Gly Pro His Gly Leu Asp Trp Leu Lys Ile His Leu Val Asn Leu 
        835                 840                 845             


Thr Gly Leu Lys Lys Arg Glu Pro Leu Arg Lys Arg Leu Ala Phe Ala 
    850                 855                 860                 


Glu Glu Val Met Asp Asp Ile Leu Asp Ser Ala Asp Gln Pro Leu Thr 
865                 870                 875                 880 


Gly Arg Lys Trp Trp Met Gly Ala Glu Glu Pro Trp Gln Thr Leu Ala 
                885                 890                 895     


Cys Cys Met Glu Val Ala Asn Ala Val Arg Ala Ser Asp Pro Ala Ala 
            900                 905                 910         


Tyr Val Ser His Leu Pro Val His Gln Asp Gly Ser Cys Asn Gly Leu 
        915                 920                 925             


Gln His Tyr Ala Ala Leu Gly Arg Asp Ser Val Gly Ala Ala Ser Val 
    930                 935                 940                 


Asn Leu Glu Pro Ser Asp Val Pro Gln Asp Val Tyr Ser Gly Val Ala 
945                 950                 955                 960 


Ala Gln Val Glu Val Phe Arg Arg Gln Asp Ala Gln Arg Gly Met Arg 
                965                 970                 975     


Val Ala Gln Val Leu Glu Gly Phe Ile Thr Arg Lys Val Val Lys Gln 
            980                 985                 990         


Thr Val Met Thr Val Val Tyr Gly  Val Thr Arg Tyr Gly  Gly Arg Leu 
        995                 1000                 1005             


Gln Ile  Glu Lys Arg Leu Arg  Glu Leu Ser Asp Phe  Pro Gln Glu 
    1010                 1015                 1020             


Phe Val  Trp Glu Ala Ser His  Tyr Leu Val Arg Gln  Val Phe Lys 
    1025                 1030                 1035             


Ser Leu  Gln Glu Met Phe Ser  Gly Thr Arg Ala Ile  Gln His Trp 
    1040                 1045                 1050             


Leu Thr  Glu Ser Ala Arg Leu  Ile Ser His Met Gly  Ser Val Val 
    1055                 1060                 1065             


Glu Trp  Val Thr Pro Leu Gly  Val Pro Val Ile Gln  Pro Tyr Arg 
    1070                 1075                 1080             


Leu Asp  Ser Lys Val Lys Gln  Ile Gly Gly Gly Ile  Gln Ser Ile 
    1085                 1090                 1095             


Thr Tyr  Thr His Asn Gly Asp  Ile Ser Arg Lys Pro  Asn Thr Arg 
    1100                 1105                 1110             


Lys Gln  Lys Asn Gly Phe Pro  Pro Asn Phe Ile His  Ser Leu Asp 
    1115                 1120                 1125             


Ser Ser  His Met Met Leu Thr  Ala Leu His Cys Tyr  Arg Lys Gly 
    1130                 1135                 1140             


Leu Thr  Phe Val Ser Val His  Asp Cys Tyr Trp Thr  His Ala Ala 
    1145                 1150                 1155             


Asp Val  Ser Val Met Asn Gln  Val Cys Arg Glu Gln  Phe Val Arg 
    1160                 1165                 1170             


Leu His  Ser Glu Pro Ile Leu  Gln Asp Leu Ser Arg  Phe Leu Val 
    1175                 1180                 1185             


Lys Arg  Phe Cys Ser Glu Pro  Gln Lys Ile Leu Glu  Ala Ser Gln 
    1190                 1195                 1200             


Leu Lys  Glu Thr Leu Gln Ala  Val Pro Lys Pro Gly  Ala Phe Asp 
    1205                 1210                 1215             


Leu Glu  Gln Val Lys Arg Ser  Thr Tyr Phe Phe Ser  
    1220                 1225                 1230 


<210>  40
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide - a nuclear localization signal

<400>  40

Pro Lys Lys Lys Arg Lys Val 
1               5           


