                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> INHIBITORS OF MICRORNAs THAT REGULATE PRODUCTION OF ATRIAL 
      NATRIURETIC PEPTIDE (ANP) AS THERAPEUTICS AND USES THEREOF

<130> 030258-074601-PCT

<140>
<141>

<150> 61/660,240
<151> 2012-06-15

<160> 58    

<170> PatentIn version 3.5

<210> 1
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
aaugacacga ucacucccgu uga                                               23


<210> 2
<211> 6
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
augaca                                                                   6


<210> 3
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
ttactgtgct agtgagggca act                                               23


<210> 4
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ugagaugaca cuguagcu                                                     18


<210> 5
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
cggcaacaag aaacugccug ag                                                22


<210> 6
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
agugacacga ucacucccgu uga                                               23


<210> 7
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
aucacaacuc cauggcaaca agaugacaca aaugcagcag agacc                       45


<210> 8
<211> 7
<212> DNA
<213> Homo sapiens

<400> 8
atgacac                                                                  7


<210> 9
<211> 7
<212> DNA
<213> Homo sapiens

<400> 9
gtgacac                                                                  7


<210> 10
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
gcggagctca gataacagcc agggaggaca ag                                     32


<210> 11
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
gctctagatt gtcttctgtc catggtgctg aag                                    33


<210> 12
<211> 858
<212> DNA
<213> Homo sapiens
 
<400> 12
gagacaggga cagacgtagg ccaagagagg ggaaccagag aggaaccaga ggggagagac       60

agagcagcaa gcagtggatt gctccttgac gacgccagca tgagctcctt ctccaccacc      120

accgtgagct tcctcctttt actggcattc cagctcctag gtcagaccag agctaatccc      180

atgtacaatg ccgtgtccaa cgcagacctg atggatttca agaatttgct ggaccatttg      240

gaagaaaaga tgcctttaga agatgaggtc gtgcccccac aagtgctcag tgagccgaat      300

gaagaagcgg gggctgctct cagccccctc cctgaggtgc ctccctggac cggggaagtc      360

agcccagccc agagagatgg aggtgccctc gggcggggcc cctgggactc ctctgatcga      420

tctgccctcc taaaaagcaa gctgagggcg ctgctcactg cccctcggag cctgcggaga      480

tccagctgct tcgggggcag gatggacagg attggagccc agagcggact gggctgtaac      540

agcttccggt actgaagata acagccaggg aggacaagca gggctgggcc tagggacaga      600

ctgcaagagg ctcctgtccc ctggggtctc tgctgcattt gtgtcatctt gttgccatgg      660

agttgtgatc atcccatcta agctgcagct tcctgtcaac acttctcaca tcttatgcta      720

actgtagata aagtggtttg atggtgactt cctcgcctct cccaccccat gcattaaatt      780

ttaaggtaga acctcacctg ttactgaaag tggtttgaaa gtgaataaac ttcagcacca      840

tggacagaag acaaaaaa                                                    858


<210> 13
<211> 87
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gaaagcgcuu uggaaugaca cgaucacucc cguugagugg gcacccgaga agccaucggg       60

aaugucgugu ccgcccagug cucuuuc                                           87


<210> 14
<211> 29
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GALA 
      peptide

<400> 14
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 15
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: EALA 
      polypeptide

<400> 15
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 16
<211> 15
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Exemplary 
      endosomolytic/fusogenic peptide

<400> 16
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 17
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: INF-7
      peptide

<400> 17
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly 
            20          


<210> 18
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Inf HA-2
      peptide

<400> 18
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 19
<211> 48
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: diINF-7 
      polypeptide

<400> 19
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly 
            20                  25                  30          


Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly Cys 
        35                  40                  45              


<210> 20
<211> 44
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: diINF-3
      polypeptide

<400> 20
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile 
            20                  25                  30          


Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Gly Cys 
        35                  40                  


<210> 21
<211> 35
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GLF 
      polypeptide

<400> 21
Gly Leu Phe Gly Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu 
1               5                   10                  15      


His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly 
            20                  25                  30          


Gly Ser Cys 
        35  


<210> 22
<211> 34
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GALA-INF3
      polypeptide

<400> 22
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly Gly 
            20                  25                  30          


Ser Cys 
        


<210> 23
<211> 41
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: INF-5
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleucine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Norleucine

<400> 23
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ile Asp Gly Lys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu 
            20                  25                  30          


Asn Gly Trp Glu Gly Leu Ile Asp Gly 
        35                  40      


<210> 24
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: JTS-1
      peptide

<400> 24
Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu Leu 
1               5                   10                  15      


Leu Glu Ala 
            


<210> 25
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: ppTG1 
      peptide

<400> 25
Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu 
1               5                   10                  15      


Leu Leu Lys Ala 
            20  


<210> 26
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: ppTG20 
      peptide 

<400> 26
Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Leu Arg Ala 
            20  


<210> 27
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: KALA 
      polypeptide

<400> 27
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210> 28
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: HA 
      peptide

<400> 28
Gly Leu Phe Phe Glu Ala Ile Ala Glu Phe Ile Glu Gly Gly Trp Glu 
1               5                   10                  15      


Gly Leu Ile Glu Gly Cys 
            20          


<210> 29
<211> 26
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Melittin 
      peptide

<400> 29
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 30
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Exemplary 
      endosomolytic/fusogenic peptide

<400> 30
His His His His His Trp Tyr Gly 
1               5               


<210> 31
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Exemplary 
      endosomolytic/fusogenic peptide

<400> 31
Cys His Lys Lys Lys Lys Lys Lys His Cys 
1               5                   10      


<210> 32
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Penetratin 
      peptide

<400> 32
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 33
<211> 14
<212> PRT
<213> Human immunodeficiency virus

<400> 33
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys 
1               5                   10                  


<210> 34
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Signal 
      peptide

<400> 34
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 35
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: PVEC 
      peptide

<400> 35
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 36
<211> 26
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Transportan 
      peptide

<400> 36
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210> 37
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Amphiphilic 
      model peptide

<400> 37
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 38
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Exemplary 
      cell permeation peptide

<400> 38
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 39
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bacterial 
      cell wall permeating peptide

<400> 39
Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210> 40
<211> 37
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: LL-37 
      polypeptide

<400> 40
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 41
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cecropin 
      P1 polypeptide

<400> 41
Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210> 42
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Alpha-defensin 
      polypeptide

<400> 42
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 43
<211> 36
<212> PRT
<213> Unknown

<220> 
<223> Description of Unknown: Beta-defensin 
      polypeptide

<400> 43
Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210> 44
<211> 42
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: PR-39
      polypeptide

<400> 44
Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro Gly Lys Arg 
        35                  40          


<210> 45
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Indolicidin 
      peptide

<400> 45
Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210> 46
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: RFGF 
      peptide

<400> 46
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 47
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: RFGF 
      analogue peptide

<400> 47
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 48
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Bactenecin 
      peptide

<400> 48
Arg Lys Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210> 49
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
gtcatcttgt tgccatagag ttgtgatcat ccc                                    33


<210> 50
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
gggatgatca caactctatg gcaacaagat gac                                    33


<210> 51
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
ucuacagugc acgugucucc agu                                               23


<210> 52
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
ucgaggagcu cacagucuag u                                                 21


<210> 53
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
uguaacagca acuccaugug ga                                                22


<210> 54
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
acaggugagg uucuugggag cc                                                22


<210> 55
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
ugagaugaag cacuguagcu c                                                 21


<210> 56
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
uuaaugcuaa ucgugauagg ggu                                               23


<210> 57
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
ugagaccucu ggguucugag cu                                                22


<210> 58
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
caagucacua gugguuccgu u                                                 21



