                         SEQUENCE LISTING

<110>  	Pires, Eusebio
       	Herr, John C
		University of Virginia Patent Foundation
 
<120>  Compositions and Methods for Treating 
       Cancer

<130>  1036.225WO1

<150>  U.S. 61/659,049
<151>  2012-06-13

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  1320
<212>  DNA
<213>  mus musculus

<400>  1
atggcctctc tgaagaggtt tcagacgctc gtgcccctgg atcacaaaca aggtacctta       60

tttgaaatta ttggagagcc caagttgccc aagtggttcc atgtcgaatg cctggaagat      120

ccaaaaagac tgtacgtgga acctcggcta ctggaaatca tgtttggtaa ggatggagag      180

cacatcccac atcttgaatc tatgttgcac accctgatac atgtgaacgt gtggggccct      240

gaaaggcgag ctgagatttg gatattcgga ccgccgcctt tccgaaggga cgttgaccgg      300

atgctcactg atctggctca ctattgccgc atgaaactga tggaaataga ggctctggag      360

gctggagttg agcgtcgtcg tatggcggcc cataaggctg ccacccagcc tgctcccgtg      420

aaggtccgcg aggctgcccc tcggcccgct tccgtgaagg tccctgagac ggccacccag      480

cctgctcccg tgaaggtccg cgaggctgcc cctcagcccg ctccggtgca ggaggtccgc      540

gaggctgccc ctcagcaggc ttccgtgcag gaggaggtcc gcgaggctgc caccgagcag      600

gctcccgtgc aggaggtccg cgaggctgcc accgagcagg ctcccgtgca ggaggtcagc      660

gaggctgcca ccgagcaggc tcccgtgcag gaggtcaacg aggctgccac cgagcaggct      720

tccgtgcagg cggtccgcga ggctgccacc cggccggctc ccgggaaggt ccgcaaggcg      780

gccacccagc cggctccggt gcaggtttgc caggaggcca cccagttggc tcccgtgaag      840

gtccgcgagg cggccaccca gccggcttcc gggaaggtcc gcgaggcggc cacccagttg      900

gctcctgtga aggtccgcaa ggcagccacc cagttggctc ctgtgaaggt ccacgaggcg      960

gccacccagc cggctccggg gaaggtcagc gatgctgcca cgcagtcggc ttcggtgcag     1020

gttcgtgagg ctgccacgca gctgtctccc gtggaggcca ctgatactag ccagttggct     1080

caggtgaagg ctgatgaagc ctttgcccag cacacttcag gggaggccca ccaggttgcc     1140

aatgggcagt ctcccattga agtctgtgag actgccaccg ggcagcattc tctagatgtc     1200

tctagggcct tgtcccagaa gtgtcctgag gtttttgagt gggagaccca gagttgtttg     1260

gatggcagct atgtcatagt tcagcctcca agggatgcct gggaatcatt tatcatatta     1320


<210>  2
<211>  440
<212>  PRT
<213>  mus musculus

<400>  2

Met Ala Ser Leu Lys Arg Phe Gln Thr Leu Val Pro Leu Asp His Lys 
1               5                   10                  15      


Gln Gly Thr Leu Phe Glu Ile Ile Gly Glu Pro Lys Leu Pro Lys Trp 
            20                  25                  30          


Phe His Val Glu Cys Leu Glu Asp Pro Lys Arg Leu Tyr Val Glu Pro 
        35                  40                  45              


Arg Leu Leu Glu Ile Met Phe Gly Lys Asp Gly Glu His Ile Pro His 
    50                  55                  60                  


Leu Glu Ser Met Leu His Thr Leu Ile His Val Asn Val Trp Gly Pro 
65                  70                  75                  80  


Glu Arg Arg Ala Glu Ile Trp Ile Phe Gly Pro Pro Pro Phe Arg Arg 
                85                  90                  95      


Asp Val Asp Arg Met Leu Thr Asp Leu Ala His Tyr Cys Arg Met Lys 
            100                 105                 110         


Leu Met Glu Ile Glu Ala Leu Glu Ala Gly Val Glu Arg Arg Arg Met 
        115                 120                 125             


Ala Ala His Lys Ala Ala Thr Gln Pro Ala Pro Val Lys Val Arg Glu 
    130                 135                 140                 


Ala Ala Pro Arg Pro Ala Ser Val Lys Val Pro Glu Thr Ala Thr Gln 
145                 150                 155                 160 


Pro Ala Pro Val Lys Val Arg Glu Ala Ala Pro Gln Pro Ala Pro Val 
                165                 170                 175     


Gln Glu Val Arg Glu Ala Ala Pro Gln Gln Ala Ser Val Gln Glu Glu 
            180                 185                 190         


Val Arg Glu Ala Ala Thr Glu Gln Ala Pro Val Gln Glu Val Arg Glu 
        195                 200                 205             


Ala Ala Thr Glu Gln Ala Pro Val Gln Glu Val Ser Glu Ala Ala Thr 
    210                 215                 220                 


Glu Gln Ala Pro Val Gln Glu Val Asn Glu Ala Ala Thr Glu Gln Ala 
225                 230                 235                 240 


Ser Val Gln Ala Val Arg Glu Ala Ala Thr Arg Pro Ala Pro Gly Lys 
                245                 250                 255     


Val Arg Lys Ala Ala Thr Gln Pro Ala Pro Val Gln Val Cys Gln Glu 
            260                 265                 270         


Ala Thr Gln Leu Ala Pro Val Lys Val Arg Glu Ala Ala Thr Gln Pro 
        275                 280                 285             


Ala Ser Gly Lys Val Arg Glu Ala Ala Thr Gln Leu Ala Pro Val Lys 
    290                 295                 300                 


Val Arg Lys Ala Ala Thr Gln Leu Ala Pro Val Lys Val His Glu Ala 
305                 310                 315                 320 


Ala Thr Gln Pro Ala Pro Gly Lys Val Ser Asp Ala Ala Thr Gln Ser 
                325                 330                 335     


Ala Ser Val Gln Val Arg Glu Ala Ala Thr Gln Leu Ser Pro Val Glu 
            340                 345                 350         


Ala Thr Asp Thr Ser Gln Leu Ala Gln Val Lys Ala Asp Glu Ala Phe 
        355                 360                 365             


Ala Gln His Thr Ser Gly Glu Ala His Gln Val Ala Asn Gly Gln Ser 
    370                 375                 380                 


Pro Ile Glu Val Cys Glu Thr Ala Thr Gly Gln His Ser Leu Asp Val 
385                 390                 395                 400 


Ser Arg Ala Leu Ser Gln Lys Cys Pro Glu Val Phe Glu Trp Glu Thr 
                405                 410                 415     


Gln Ser Cys Leu Asp Gly Ser Tyr Val Ile Val Gln Pro Pro Arg Asp 
            420                 425                 430         


Ala Trp Glu Ser Phe Ile Ile Leu 
        435                 440 


<210>  3
<211>  1248
<212>  DNA
<213>  mus musculus

<400>  3
atggcctctc tgaagaggtt tcagacgctc gtgcccctgg atcacaaaca aggtacctta       60

tttgaaatta ttggagagcc caagttgccc aagtggttcc atgtcgaatg cctggaagat      120

ccaaaaagac tgtacgtgga acctcggcta ctggaaatca tgtttggtaa ggatggagag      180

cacatcccac atcttgaatc tatgttgcac accctgatac atgtgaacgt gtggggccct      240

gaaaggcgag ctgagatttg gatattcgga ccgccgcctt tccgaaggga cgttgaccgg      300

atgctcactg atctggctca ctattgccgc atgaaactga tggaaataga ggctctggag      360

gctggagttg agcgtcgtcg tatggcggcc cataaggctg ccacccagcc tgctcccgtg      420

aaggtccgcg aggctgcccc tcagcccgct ccggtgcagg aggtccgcga ggctgcccct      480

cagcaggctt ccgtgcagga ggaggtccgc gaggctgcca ccgagcaggc tcccgtgcag      540

gaggtccgcg aggctgccac cgagcaggct cccgtgcagg aggtcagcga ggctgccacc      600

gagcaggctc ccgtgcagga ggtcaacgag gctgccaccg agcaggcttc cgtgcaggcg      660

gtccgcgagg ctgccacccg gccggctccc gggaaggtcc gcaaggcggc cacccagccg      720

gctccggtgc aggtttgcca ggaggccacc cagttggctc ccgtgaaggt ccgcgaggcg      780

gccacccagc cggcttccgg gaaggtccgc gaggcggcca cccagttggc tcctgtgaag      840

gtccgcaagg cagccaccca gttggctcct gtgaaggtcc acgaggcggc cacccagccg      900

gctccgggga aggtcagcga tgctgccacg cagtcggctt cggtgcaggt tcgtgaggct      960

gccacgcagc tgtctcccgt ggaggccact gatactagcc agttggctca ggtgaaggct     1020

gatgaagcct ttgcccagca cacttcaggg gaggcccacc aggttgccaa tgggcagtct     1080

cccattgaag tctgtgagac tgccaccggg cagcattctc tagatgtctc tagggccttg     1140

tcccagaagt gtcctgaggt ttttgagtgg gagacccaga gttgtttgga tggcagctat     1200

gtcatagttc agcctccaag ggatgcctgg gaatcattta tcatatta                  1248


<210>  4
<211>  416
<212>  PRT
<213>  mus musculus

<400>  4

Met Ala Ser Leu Lys Arg Phe Gln Thr Leu Val Pro Leu Asp His Lys 
1               5                   10                  15      


Gln Gly Thr Leu Phe Glu Ile Ile Gly Glu Pro Lys Leu Pro Lys Trp 
            20                  25                  30          


Phe His Val Glu Cys Leu Glu Asp Pro Lys Arg Leu Tyr Val Glu Pro 
        35                  40                  45              


Arg Leu Leu Glu Ile Met Phe Gly Lys Asp Gly Glu His Ile Pro His 
    50                  55                  60                  


Leu Glu Ser Met Leu His Thr Leu Ile His Val Asn Val Trp Gly Pro 
65                  70                  75                  80  


Glu Arg Arg Ala Glu Ile Trp Ile Phe Gly Pro Pro Pro Phe Arg Arg 
                85                  90                  95      


Asp Val Asp Arg Met Leu Thr Asp Leu Ala His Tyr Cys Arg Met Lys 
            100                 105                 110         


Leu Met Glu Ile Glu Ala Leu Glu Ala Gly Val Glu Arg Arg Arg Met 
        115                 120                 125             


Ala Ala His Lys Ala Ala Thr Gln Pro Ala Pro Val Lys Val Arg Glu 
    130                 135                 140                 


Ala Ala Pro Gln Pro Ala Pro Val Gln Glu Val Arg Glu Ala Ala Pro 
145                 150                 155                 160 


Gln Gln Ala Ser Val Gln Glu Glu Val Arg Glu Ala Ala Thr Glu Gln 
                165                 170                 175     


Ala Pro Val Gln Glu Val Arg Glu Ala Ala Thr Glu Gln Ala Pro Val 
            180                 185                 190         


Gln Glu Val Ser Glu Ala Ala Thr Glu Gln Ala Pro Val Gln Glu Val 
        195                 200                 205             


Asn Glu Ala Ala Thr Glu Gln Ala Ser Val Gln Ala Val Arg Glu Ala 
    210                 215                 220                 


Ala Thr Arg Pro Ala Pro Gly Lys Val Arg Lys Ala Ala Thr Gln Pro 
225                 230                 235                 240 


Ala Pro Val Gln Val Cys Gln Glu Ala Thr Gln Leu Ala Pro Val Lys 
                245                 250                 255     


Val Arg Glu Ala Ala Thr Gln Pro Ala Ser Gly Lys Val Arg Glu Ala 
            260                 265                 270         


Ala Thr Gln Leu Ala Pro Val Lys Val Arg Lys Ala Ala Thr Gln Leu 
        275                 280                 285             


Ala Pro Val Lys Val His Glu Ala Ala Thr Gln Pro Ala Pro Gly Lys 
    290                 295                 300                 


Val Ser Asp Ala Ala Thr Gln Ser Ala Ser Val Gln Val Arg Glu Ala 
305                 310                 315                 320 


Ala Thr Gln Leu Ser Pro Val Glu Ala Thr Asp Thr Ser Gln Leu Ala 
                325                 330                 335     


Gln Val Lys Ala Asp Glu Ala Phe Ala Gln His Thr Ser Gly Glu Ala 
            340                 345                 350         


His Gln Val Ala Asn Gly Gln Ser Pro Ile Glu Val Cys Glu Thr Ala 
        355                 360                 365             


Thr Gly Gln His Ser Leu Asp Val Ser Arg Ala Leu Ser Gln Lys Cys 
    370                 375                 380                 


Pro Glu Val Phe Glu Trp Glu Thr Gln Ser Cys Leu Asp Gly Ser Tyr 
385                 390                 395                 400 


Val Ile Val Gln Pro Pro Arg Asp Ala Trp Glu Ser Phe Ile Ile Leu 
                405                 410                 415     


<210>  5
<211>  1242
<212>  DNA
<213>  mus musculus

<400>  5
atgggagcac cctcagcatc cagatgttct ggagtctgca gtaccagtgt tccagaaggc       60

ttcactcctg agggaagccc ggtatttcag gacaaggaca tccccgcaat taaccaaggg      120

ctcatctcag aggagacccc agaaagcagc ttcctggtag aaggggacat tatccggcca      180

agccctttcc gattgttgtc agtgaccaat aataaatggc ccaagggcgt tggtggcttt      240

gtggagatcc ccttcctgct ttccagaaag tatgatgaac tcagccgccg ggtcattatg      300

gatgcctttg ctgagtttga acgtttcaca tgcatccggt ttgttgccta ccatggtcag      360

agagactttg tttccattct tcctatggcg gggtgtttct ctggtgtggg acgcagtgga      420

gggatgcagg tggtgtcctt ggcacccact tgtctccgga agggccgagg cattgtccta      480

catgagctca tgcacgtact tggcttctgg catgagcatt cacgggcaga tcgggaccgc      540

tacatccaag tcaactggaa cgagatcctc ccgggctttg aaatcaactt catcaagtca      600

cggagtacca atatgttagt tccctatgac tactcatctg tgatgcatta tgggagattt      660

gccttcagct ggcgtgggca gcccaccatc ataccactct ggacctccag tgttcacatt      720

ggccagcgat ggaacctgag tacctcagat atcacccggg tctgcaggct gtataactgc      780

agccggagtg tccctgactc ccacgggaga gggtttgagg cccagagtga tggaagcagc      840

ctcacccctg cctctatatc acgtctacaa agacttctcg aggcactgtc agaggaatct      900

ggaagctctg cccctagtgg ctccaggact ggaggccaga gtattgccgg gcttggtaac      960

agccagcaag gatgggagca tcctcctcag agcacattca gtgtgggagc cttggcaaga     1020

ccacctcaga tgctagccga tgcttcaaaa tcggggcctg gagcaggtgc agacagcttg     1080

tctctagagc agttccagct agcccaggcc cccactgtac ctcttgctct atttccagaa     1140

gccagagaca agccagcacc tatccaagat gcctttgaga ggctagctcc acttccagga     1200

ggctgtgcac ctggaagtca cattagagag gtgcccagag ac                        1242


<210>  6
<211>  414
<212>  PRT
<213>  mus musculus

<400>  6

Met Gly Ala Pro Ser Ala Ser Arg Cys Ser Gly Val Cys Ser Thr Ser 
1               5                   10                  15      


Val Pro Glu Gly Phe Thr Pro Glu Gly Ser Pro Val Phe Gln Asp Lys 
            20                  25                  30          


Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Ser Glu Glu Thr Pro Glu 
        35                  40                  45              


Ser Ser Phe Leu Val Glu Gly Asp Ile Ile Arg Pro Ser Pro Phe Arg 
    50                  55                  60                  


Leu Leu Ser Val Thr Asn Asn Lys Trp Pro Lys Gly Val Gly Gly Phe 
65                  70                  75                  80  


Val Glu Ile Pro Phe Leu Leu Ser Arg Lys Tyr Asp Glu Leu Ser Arg 
                85                  90                  95      


Arg Val Ile Met Asp Ala Phe Ala Glu Phe Glu Arg Phe Thr Cys Ile 
            100                 105                 110         


Arg Phe Val Ala Tyr His Gly Gln Arg Asp Phe Val Ser Ile Leu Pro 
        115                 120                 125             


Met Ala Gly Cys Phe Ser Gly Val Gly Arg Ser Gly Gly Met Gln Val 
    130                 135                 140                 


Val Ser Leu Ala Pro Thr Cys Leu Arg Lys Gly Arg Gly Ile Val Leu 
145                 150                 155                 160 


His Glu Leu Met His Val Leu Gly Phe Trp His Glu His Ser Arg Ala 
                165                 170                 175     


Asp Arg Asp Arg Tyr Ile Gln Val Asn Trp Asn Glu Ile Leu Pro Gly 
            180                 185                 190         


Phe Glu Ile Asn Phe Ile Lys Ser Arg Ser Thr Asn Met Leu Val Pro 
        195                 200                 205             


Tyr Asp Tyr Ser Ser Val Met His Tyr Gly Arg Phe Ala Phe Ser Trp 
    210                 215                 220                 


Arg Gly Gln Pro Thr Ile Ile Pro Leu Trp Thr Ser Ser Val His Ile 
225                 230                 235                 240 


Gly Gln Arg Trp Asn Leu Ser Thr Ser Asp Ile Thr Arg Val Cys Arg 
                245                 250                 255     


Leu Tyr Asn Cys Ser Arg Ser Val Pro Asp Ser His Gly Arg Gly Phe 
            260                 265                 270         


Glu Ala Gln Ser Asp Gly Ser Ser Leu Thr Pro Ala Ser Ile Ser Arg 
        275                 280                 285             


Leu Gln Arg Leu Leu Glu Ala Leu Ser Glu Glu Ser Gly Ser Ser Ala 
    290                 295                 300                 


Pro Ser Gly Ser Arg Thr Gly Gly Gln Ser Ile Ala Gly Leu Gly Asn 
305                 310                 315                 320 


Ser Gln Gln Gly Trp Glu His Pro Pro Gln Ser Thr Phe Ser Val Gly 
                325                 330                 335     


Ala Leu Ala Arg Pro Pro Gln Met Leu Ala Asp Ala Ser Lys Ser Gly 
            340                 345                 350         


Pro Gly Ala Gly Ala Asp Ser Leu Ser Leu Glu Gln Phe Gln Leu Ala 
        355                 360                 365             


Gln Ala Pro Thr Val Pro Leu Ala Leu Phe Pro Glu Ala Arg Asp Lys 
    370                 375                 380                 


Pro Ala Pro Ile Gln Asp Ala Phe Glu Arg Leu Ala Pro Leu Pro Gly 
385                 390                 395                 400 


Gly Cys Ala Pro Gly Ser His Ile Arg Glu Val Pro Arg Asp 
                405                 410                 


<210>  7
<211>  1176
<212>  DNA
<213>  mus musculus

<400>  7
atgggagcac cctcagcatc cagatgttct ggagtctgca gtaccagtgt tccagaaggc       60

ttcactcctg agggaagccc ggtatttcag gacaaggaca tccccgcaat taaccaaggg      120

ctcatctcag aggagacccc agaaagcagc ttcctggtag aaggggacat tatccggcca      180

ggggtcagcc acggtgtgtc tttcccagat gaactcagcc gccgggtcat tatggatgcc      240

tttgctgagt ttgaacgttt cacatgcatc cggtttgttg cctaccatgg tcagagagac      300

tttgtttcca ttcttcctat ggcggggtgt ttctctggtg tgggacgcag tggagggatg      360

caggtggtgt ccttggcacc cacttgtctc cggaagggcc gaggcattgt cctacatgag      420

ctcatgcacg tacttggctt ctggcatgag cattcacggg cagatcggga ccgctacatc      480

caagtcaact ggaacgagat cctcccgggc tttgaaatca acttcatcaa gtcacggagt      540

accaatatgt tagttcccta tgactactca tctgtgatgc attatgggag atttgccttc      600

agctggcgtg ggcagcccac catcatacca ctctggacct ccagtgttca cattggccag      660

cgatggaacc tgagtacctc agatatcacc cgggtctgca ggctgtataa ctgcagccgg      720

agtgtccctg actcccacgg gagagggttt gaggcccaga gtgatggaag cagcctcacc      780

cctgcctcta tatcacgtct acaaagactt ctcgaggcac tgtcagagga atctggaagc      840

tctgccccta gtggctccag gactggaggc cagagtattg ccgggcttgg taacagccag      900

caaggatggg agcatcctcc tcagagcaca ttcagtgtgg gagccttggc aagaccacct      960

cagatgctag ccgatgcttc aaaatcgggg cctggagcag gtgcagacag cttgtctcta     1020

gagcagttcc agctagccca ggcccccact gtacctcttg ctctatttcc agaagccaga     1080

gacaagccag cacctatcca agatgccttt gagaggctag ctccacttcc aggaggctgt     1140

gcacctggaa gtcacattag agaggtgccc agagac                               1176


<210>  8
<211>  392
<212>  PRT
<213>  mus musculus

<400>  8

Met Gly Ala Pro Ser Ala Ser Arg Cys Ser Gly Val Cys Ser Thr Ser 
1               5                   10                  15      


Val Pro Glu Gly Phe Thr Pro Glu Gly Ser Pro Val Phe Gln Asp Lys 
            20                  25                  30          


Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Ser Glu Glu Thr Pro Glu 
        35                  40                  45              


Ser Ser Phe Leu Val Glu Gly Asp Ile Ile Arg Pro Gly Val Ser His 
    50                  55                  60                  


Gly Val Ser Phe Pro Asp Glu Leu Ser Arg Arg Val Ile Met Asp Ala 
65                  70                  75                  80  


Phe Ala Glu Phe Glu Arg Phe Thr Cys Ile Arg Phe Val Ala Tyr His 
                85                  90                  95      


Gly Gln Arg Asp Phe Val Ser Ile Leu Pro Met Ala Gly Cys Phe Ser 
            100                 105                 110         


Gly Val Gly Arg Ser Gly Gly Met Gln Val Val Ser Leu Ala Pro Thr 
        115                 120                 125             


Cys Leu Arg Lys Gly Arg Gly Ile Val Leu His Glu Leu Met His Val 
    130                 135                 140                 


Leu Gly Phe Trp His Glu His Ser Arg Ala Asp Arg Asp Arg Tyr Ile 
145                 150                 155                 160 


Gln Val Asn Trp Asn Glu Ile Leu Pro Gly Phe Glu Ile Asn Phe Ile 
                165                 170                 175     


Lys Ser Arg Ser Thr Asn Met Leu Val Pro Tyr Asp Tyr Ser Ser Val 
            180                 185                 190         


Met His Tyr Gly Arg Phe Ala Phe Ser Trp Arg Gly Gln Pro Thr Ile 
        195                 200                 205             


Ile Pro Leu Trp Thr Ser Ser Val His Ile Gly Gln Arg Trp Asn Leu 
    210                 215                 220                 


Ser Thr Ser Asp Ile Thr Arg Val Cys Arg Leu Tyr Asn Cys Ser Arg 
225                 230                 235                 240 


Ser Val Pro Asp Ser His Gly Arg Gly Phe Glu Ala Gln Ser Asp Gly 
                245                 250                 255     


Ser Ser Leu Thr Pro Ala Ser Ile Ser Arg Leu Gln Arg Leu Leu Glu 
            260                 265                 270         


Ala Leu Ser Glu Glu Ser Gly Ser Ser Ala Pro Ser Gly Ser Arg Thr 
        275                 280                 285             


Gly Gly Gln Ser Ile Ala Gly Leu Gly Asn Ser Gln Gln Gly Trp Glu 
    290                 295                 300                 


His Pro Pro Gln Ser Thr Phe Ser Val Gly Ala Leu Ala Arg Pro Pro 
305                 310                 315                 320 


Gln Met Leu Ala Asp Ala Ser Lys Pro Gly Pro Gly Ala Gly Ala Asp 
                325                 330                 335     


Ser Leu Ser Leu Glu Gln Phe Gln Leu Ala Gln Ala Pro Thr Val Pro 
            340                 345                 350         


Leu Ala Leu Phe Pro Glu Ala Arg Asp Lys Pro Ala Pro Ile Gln Asp 
        355                 360                 365             


Ala Phe Glu Arg Leu Ala Pro Leu Pro Gly Gly Cys Ala Pro Gly Ser 
    370                 375                 380                 


His Ile Arg Glu Val Pro Arg Asp 
385                 390         


<210>  9
<211>  1140
<212>  DNA
<213>  mus musculus

<400>  9
atgggagcac cctcagcatc cagatgttct ggagtctgca gtaccagtgt tccagaaggc       60

ttcactcctg agggaagccc ggtatttcag gacaaggaca tccccgcaat taaccaaggg      120

ctcatctcag aggagacccc agaaagcagc ttcctgcttt ccagaaagta tgatgaactc      180

agccgccggg tcattatgga tgcctttgct gagtttgaac gtttcacatg catccggttt      240

gttgcctacc atggtcagag agactttgtt tccattcttc ctatggcggg gtgtttctct      300

ggtgtgggac gcagtggagg gatgcaggtg gtgtccttgg cacccacttg tctccggaag      360

ggccgaggca ttgtcctaca tgagctcatg cacgtacttg gcttctggca tgagcattca      420

cgggcagatc gggaccgcta catccaagtc aactggaacg agatcctccc gggctttgaa      480

atcaacttca tcaagtcacg gagtaccaat atgttagttc cctatgacta ctcatctgtg      540

atgcattatg ggagatttgc cttcagctgg cgtgggcagc ccaccatcat accactctgg      600

acctccagtg ttcacattgg ccagcgatgg aacctgagta cctcagatat cacccgggtc      660

tgcaggctgt ataactgcag ccggagtgtc cctgactccc acgggagagg gtttgaggcc      720

cagagtgatg gaagcagcct cacccctgcc tctatatcac gtctacaaag acttctcgag      780

gcactgtcag aggaatctgg aagctctgcc cctagtggct ccaggactgg aggccagagt      840

attgccgggc ttggtaacag ccagcaagga tgggagcatc ctcctcagag cacattcagt      900

gtgggagcct tggcaagacc acctcagatg ctagccgatg cttcaaaatc ggggcctgga      960

gcaggtgcag acagcttgtc tctagagcag ttccagctag cccaggcccc cactgtacct     1020

cttgctctat ttccagaagc cagagacaag ccagcaccta tccaagatgc ctttgagagg     1080

ctagctccac ttccaggagg ctgtgcacct ggaagtcaca ttagagaggt gcccagagac     1140


<210>  10
<211>  380
<212>  PRT
<213>  Mus musculus

<400>  10

Met Gly Ala Pro Ser Ala Ser Arg Cys Ser Gly Val Cys Ser Thr Ser 
1               5                   10                  15      


Val Pro Glu Gly Phe Thr Pro Glu Gly Ser Pro Val Phe Gln Asp Lys 
            20                  25                  30          


Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Ser Glu Glu Thr Pro Glu 
        35                  40                  45              


Ser Ser Phe Leu Leu Ser Arg Lys Tyr Asp Glu Leu Ser Arg Arg Val 
    50                  55                  60                  


Ile Met Asp Ala Phe Ala Glu Phe Glu Arg Phe Thr Cys Ile Arg Phe 
65                  70                  75                  80  


Val Ala Tyr His Gly Gln Arg Asp Phe Val Ser Ile Leu Pro Met Ala 
                85                  90                  95      


Gly Cys Phe Ser Gly Val Gly Arg Ser Gly Gly Met Gln Val Val Ser 
            100                 105                 110         


Leu Ala Pro Thr Cys Leu Arg Lys Gly Arg Gly Ile Val Leu His Glu 
        115                 120                 125             


Leu Met His Val Leu Gly Phe Trp His Glu His Ser Arg Ala Asp Arg 
    130                 135                 140                 


Asp Arg Tyr Ile Gln Val Asn Trp Asn Glu Ile Leu Pro Gly Phe Glu 
145                 150                 155                 160 


Ile Asn Phe Ile Lys Ser Arg Ser Thr Asn Met Leu Val Pro Tyr Asp 
                165                 170                 175     


Tyr Ser Ser Val Met His Tyr Gly Arg Phe Ala Phe Ser Trp Arg Gly 
            180                 185                 190         


Gln Pro Thr Ile Ile Pro Leu Trp Thr Ser Ser Val His Ile Gly Gln 
        195                 200                 205             


Arg Trp Asn Leu Ser Thr Ser Asp Ile Thr Arg Val Cys Arg Leu Tyr 
    210                 215                 220                 


Asn Cys Ser Arg Ser Val Pro Asp Ser His Gly Arg Gly Phe Glu Ala 
225                 230                 235                 240 


Gln Ser Asp Gly Ser Ser Leu Thr Pro Ala Ser Ile Ser Arg Leu Gln 
                245                 250                 255     


Arg Leu Leu Glu Ala Leu Ser Glu Glu Ser Gly Ser Ser Ala Pro Ser 
            260                 265                 270         


Gly Ser Arg Thr Gly Gly Gln Ser Ile Ala Gly Leu Gly Asn Ser Gln 
        275                 280                 285             


Gln Gly Trp Glu His Pro Pro Gln Ser Thr Phe Ser Val Gly Ala Leu 
    290                 295                 300                 


Ala Arg Pro Pro Gln Met Leu Ala Asp Ala Ser Lys Ser Gly Pro Gly 
305                 310                 315                 320 


Ala Gly Ala Asp Ser Leu Ser Leu Glu Gln Phe Gln Leu Ala Gln Ala 
                325                 330                 335     


Pro Thr Val Pro Leu Ala Leu Phe Pro Glu Ala Arg Asp Lys Pro Ala 
            340                 345                 350         


Pro Ile Gln Asp Ala Phe Glu Arg Leu Ala Pro Leu Pro Gly Gly Cys 
        355                 360                 365             


Ala Pro Gly Ser His Ile Arg Glu Val Pro Arg Asp 
    370                 375                 380 


<210>  11
<211>  384
<212>  DNA
<213>  mus musculus

<400>  11
aaggtcttca gtcgctgtga gctggccaaa gagatgcatg acttcggtct ggatggctac       60

cggggttata acctggctga ctgggtctgc cttgcttact acacaagtgg cttcaacaca      120

aatgctgtgg atcatgaagc tgatggaagc accaacaatg gcatcttcca gatcagcagc      180

cggaggtggt gcagaaccct cgcctcgaat ggccccaatc tttgcaggat atactgcact      240

gatttgttga acaatgatct caaagattct atcgtctgtg ccatgaagat agttcaagaa      300

cccctgggtc tgggctattg ggaagcctgg aggcaccact gccagggcag ggacctcagt      360

gactgggtgg atggctgtga cttc                                             384


<210>  12
<211>  128
<212>  PRT
<213>  mus musculus

<400>  12

Lys Val Phe Ser Arg Cys Glu Leu Ala Lys Glu Met His Asp Phe Gly 
1               5                   10                  15      


Leu Asp Gly Tyr Arg Gly Tyr Asn Leu Ala Asp Trp Val Cys Leu Ala 
            20                  25                  30          


Tyr Tyr Thr Ser Gly Phe Asn Thr Asn Ala Val Asp His Glu Ala Asp 
        35                  40                  45              


Gly Ser Thr Asn Asn Gly Ile Phe Gln Ile Ser Ser Arg Arg Trp Cys 
    50                  55                  60                  


Arg Thr Leu Ala Ser Asn Gly Pro Asn Leu Cys Arg Ile Tyr Cys Thr 
65                  70                  75                  80  


Asp Leu Leu Asn Asn Asp Leu Lys Asp Ser Ile Val Cys Ala Met Lys 
                85                  90                  95      


Ile Val Gln Glu Pro Leu Gly Leu Gly Tyr Trp Glu Ala Trp Arg His 
            100                 105                 110         


His Cys Gln Gly Arg Asp Leu Ser Asp Trp Val Asp Gly Cys Asp Phe 
        115                 120                 125             


<210>  13
<211>  820
<212>  DNA
<213>  mus musculus

<400>  13
gccctggcaa ggttgtgggg gacatcttga gctgaagcag ggttttgagc cactgctgct       60

gctgccattg tcaccatggt ctcagctctg cggggagcac ccctgatcag ggtgcactca      120

agccctgttt cttctccttc tgtgagtgga ccacggaggc tggtgagctg cctgtcatcc      180

caaagctcag ctctgagcca gagtggtggt ggctccacct ctgccgccgg catagaagcc      240

aggagcaggg ctctcagaag gcggtggtgc ccagctggga tcatgttgtt ggccctggtc      300

tgtctgctca gctgcctgct accctccagt gaggccaagc tctacggtcg ttgtgaactg      360

gccagagtgc tacatgactt cgggctggac ggataccggg gatacagcct ggctgactgg      420

gtctgccttg cttatttcac aagcggtttc aacgcagctg ctttggacta cgaggctgat      480

gggagcacca acaacgggat cttccagatc aacagccgga ggtggtgcag caacctcacc      540

ccgaacgtcc ccaacgtgtg ccggatgtac tgctcagatt tgttgaatcc taatctcaag      600

gataccgtta tctgtgccat gaagataacc caagagcctc agggtctggg ttactgggag      660

gcctggaggc atcactgcca gggaaaagac ctcactgaat gggtggatgg ctgtgacttc      720

taggatggac ggaaccatgc acagcaggct gggaaatgtg gtttggttcc tgacctaggc      780

ttgggaagac aagccagcga ataaaggatg gttgaacgtt                            820


<210>  14
<211>  215
<212>  PRT
<213>  homo sapien

<400>  14

Met Val Ser Ala Leu Arg Gly Ala Pro Leu Ile Arg Val His Ser Ser 
1               5                   10                  15      


Pro Val Ser Ser Pro Ser Val Ser Gly Pro Arg Arg Leu Val Ser Cys 
            20                  25                  30          


Leu Ser Ser Gln Ser Ser Ala Leu Ser Gln Ser Gly Gly Gly Ser Thr 
        35                  40                  45              


Ser Ala Ala Gly Ile Glu Ala Arg Ser Arg Ala Leu Arg Arg Arg Trp 
    50                  55                  60                  


Cys Pro Ala Gly Ile Met Leu Leu Ala Leu Val Cys Leu Leu Ser Cys 
65                  70                  75                  80  


Leu Leu Pro Ser Ser Glu Ala Lys Leu Tyr Gly Arg Cys Glu Leu Ala 
                85                  90                  95      


Arg Val Leu His Asp Phe Gly Leu Asp Gly Tyr Arg Gly Tyr Ser Leu 
            100                 105                 110         


Ala Asp Trp Val Cys Leu Ala Tyr Phe Thr Ser Gly Phe Asn Ala Ala 
        115                 120                 125             


Ala Leu Asp Tyr Glu Ala Asp Gly Ser Thr Asn Asn Gly Ile Phe Gln 
    130                 135                 140                 


Ile Asn Ser Arg Arg Trp Cys Ser Asn Leu Thr Pro Asn Val Pro Asn 
145                 150                 155                 160 


Val Cys Arg Met Tyr Cys Ser Asp Leu Leu Asn Pro Asn Leu Lys Asp 
                165                 170                 175     


Thr Val Ile Cys Ala Met Lys Ile Thr Gln Glu Pro Gln Gly Leu Gly 
            180                 185                 190         


Tyr Trp Glu Ala Trp Arg His His Cys Gln Gly Lys Asp Leu Thr Glu 
        195                 200                 205             


Trp Val Asp Gly Cys Asp Phe 
    210                 215 


<210>  15
<211>  417
<212>  DNA
<213>  mus musculus

<400>  15
aagatttatg aacgctgtga gctggcaaag aagctggagg aggctggcct cgatggcttc       60

aaaggctata ctgttggaga ctggctgtgt gtggcacact atgagagtgg ctttgacacc      120

tcttttgtgg accacaatcc agatggcagc agtgaatatg gcattttcca gctgaactct      180

gcctggtggt gtaacaatgg catcacaccc actcagaacc tctgcaacat cgattgtaat      240

gacctgctca accgccatat tctggatgat atcatatgtg ccaagagggt tgcatcctca      300

cataagagta tgaaggcctg ggattcctgg acccagcact gtgccggtca tgatttatca      360

gaatggctaa aggggtgttc tgtgcgtctg aaaactgact caagctataa taactgg         417


<210>  16
<211>  139
<212>  PRT
<213>  mus musculus

<400>  16

Lys Ile Tyr Glu Arg Cys Glu Leu Ala Lys Lys Leu Glu Glu Ala Gly 
1               5                   10                  15      


Leu Asp Gly Phe Lys Gly Tyr Thr Val Gly Asp Trp Leu Cys Val Ala 
            20                  25                  30          


His Tyr Glu Ser Gly Phe Asp Thr Ser Phe Val Asp His Asn Pro Asp 
        35                  40                  45              


Gly Ser Ser Glu Tyr Gly Ile Phe Gln Leu Asn Ser Ala Trp Trp Cys 
    50                  55                  60                  


Asn Asn Gly Ile Thr Pro Thr Gln Asn Leu Cys Asn Ile Asp Cys Asn 
65                  70                  75                  80  


Asp Leu Leu Asn Arg His Ile Leu Asp Asp Ile Ile Cys Ala Lys Arg 
                85                  90                  95      


Val Ala Ser Ser His Lys Ser Met Lys Ala Trp Asp Ser Trp Thr Gln 
            100                 105                 110         


His Cys Ala Gly His Asp Leu Ser Glu Trp Leu Lys Gly Cys Ser Val 
        115                 120                 125             


Arg Leu Lys Thr Asp Ser Ser Tyr Asn Asn Trp 
    130                 135                 


<210>  17
<211>  588
<212>  DNA
<213>  homo sapien

<400>  17
ctgggagggc ttacaggtgc cataatgaag gcctggggca ctgtggtagt gaccttggcc       60

acgctgatgg ttgtcactgt ggatgccaag atctatgaac gctgcgagct ggcggcaaga      120

ctggagagag cagggctgaa cggctacaag ggctacggcg ttggagactg gctgtgcatg      180

gctcattatg agagtggctt tgacaccgcc ttcgtggacc acaatcctga tggcagcagt      240

gaatatggca ttttccaact gaattctgcc tggtggtgtg acaatggcat tacacccacc      300

aagaacctct gccacatgga ttgtcatgac ctgctcaatc gccatattct ggatgacatc      360

aggtgtgcca agcagattgt gtcctcacag aatgggcttt ctgcctggac ttcttggagg      420

ctacactgtt ctggccatga tttatctgaa tggctcaagg ggtgtgatat gcatgtgaaa      480

attgatccaa aaattcatcc atgactcaga ttcgaagaga cagattttat cttcctttca      540

tttctttctc ttgtgcattt aataaaggat ggtatctata aacaatgc                   588


<210>  18
<211>  159
<212>  PRT
<213>  homo sapien

<400>  18

Met Lys Ala Trp Gly Thr Val Val Val Thr Leu Ala Thr Leu Met Val 
1               5                   10                  15      


Val Thr Val Asp Ala Lys Ile Tyr Glu Arg Cys Glu Leu Ala Ala Arg 
            20                  25                  30          


Leu Glu Arg Ala Gly Leu Asn Gly Tyr Lys Gly Tyr Gly Val Gly Asp 
        35                  40                  45              


Trp Leu Cys Met Ala His Tyr Glu Ser Gly Phe Asp Thr Ala Phe Val 
    50                  55                  60                  


Asp His Asn Pro Asp Gly Ser Ser Glu Tyr Gly Ile Phe Gln Leu Asn 
65                  70                  75                  80  


Ser Ala Trp Trp Cys Asp Asn Gly Ile Thr Pro Thr Lys Asn Leu Cys 
                85                  90                  95      


His Met Asp Cys His Asp Leu Leu Asn Arg His Ile Leu Asp Asp Ile 
            100                 105                 110         


Arg Cys Ala Lys Gln Ile Val Ser Ser Gln Asn Gly Leu Ser Ala Trp 
        115                 120                 125             


Thr Ser Trp Arg Leu His Cys Ser Gly His Asp Leu Ser Glu Trp Leu 
    130                 135                 140                 


Lys Gly Cys Asp Met His Val Lys Ile Asp Pro Lys Ile His Pro 
145                 150                 155                 


<210>  19
<211>  435
<212>  PRT
<213>  mus musculus

<400>  19

Met Gly Ile Met Gly Ser Leu Trp Pro Trp Ile Leu Thr Met Leu Ser 
1               5                   10                  15      


Leu Leu Gly Leu Ser Met Gly Ala Pro Ser Ala Ser Arg Cys Ser Gly 
            20                  25                  30          


Val Cys Ser Thr Ser Val Pro Glu Gly Phe Thr Pro Glu Gly Ser Pro 
        35                  40                  45              


Val Phe Gln Asp Lys Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Ser 
    50                  55                  60                  


Glu Glu Thr Pro Glu Ser Ser Phe Leu Val Glu Gly Asp Ile Ile Arg 
65                  70                  75                  80  


Pro Ser Pro Phe Arg Leu Leu Ser Val Thr Asn Asn Lys Trp Pro Lys 
                85                  90                  95      


Gly Val Gly Gly Phe Val Glu Ile Pro Phe Leu Leu Ser Arg Lys Tyr 
            100                 105                 110         


Asp Glu Leu Ser Arg Arg Val Ile Met Asp Ala Phe Ala Glu Phe Glu 
        115                 120                 125             


Arg Phe Thr Cys Ile Arg Phe Val Ala Tyr His Gly Gln Arg Asp Phe 
    130                 135                 140                 


Val Ser Ile Leu Pro Met Ala Gly Cys Phe Ser Gly Val Gly Arg Ser 
145                 150                 155                 160 


Gly Gly Met Gln Val Val Ser Leu Ala Pro Thr Cys Leu Arg Lys Gly 
                165                 170                 175     


Arg Gly Ile Val Leu His Glu Leu Met His Val Leu Gly Phe Trp His 
            180                 185                 190         


Glu His Ser Arg Ala Asp Arg Asp Arg Tyr Ile Gln Val Asn Trp Asn 
        195                 200                 205             


Glu Ile Leu Pro Gly Phe Glu Ile Asn Phe Ile Lys Ser Arg Ser Thr 
    210                 215                 220                 


Asn Met Leu Val Pro Tyr Asp Tyr Ser Ser Val Met His Tyr Gly Arg 
225                 230                 235                 240 


Phe Ala Phe Ser Trp Arg Gly Gln Pro Thr Ile Ile Pro Leu Trp Thr 
                245                 250                 255     


Ser Ser Val His Ile Gly Gln Arg Trp Asn Leu Ser Thr Ser Asp Ile 
            260                 265                 270         


Thr Arg Val Cys Arg Leu Tyr Asn Cys Ser Arg Ser Val Pro Asp Ser 
        275                 280                 285             


His Gly Arg Gly Phe Glu Ala Gln Ser Asp Gly Ser Ser Leu Thr Pro 
    290                 295                 300                 


Ala Ser Ile Ser Arg Leu Gln Arg Leu Leu Glu Ala Leu Ser Glu Glu 
305                 310                 315                 320 


Ser Gly Ser Ser Ala Pro Ser Gly Ser Arg Thr Gly Gly Gln Ser Ile 
                325                 330                 335     


Ala Gly Leu Gly Asn Ser Gln Gln Gly Trp Glu His Pro Pro Gln Ser 
            340                 345                 350         


Thr Phe Ser Val Gly Ala Leu Ala Arg Pro Pro Gln Met Leu Ala Asp 
        355                 360                 365             


Ala Ser Lys Ser Gly Pro Gly Ala Gly Ala Asp Ser Leu Ser Leu Glu 
    370                 375                 380                 


Gln Phe Gln Leu Ala Gln Ala Pro Thr Val Pro Leu Ala Leu Phe Pro 
385                 390                 395                 400 


Glu Ala Arg Asp Lys Pro Ala Pro Ile Gln Asp Ala Phe Glu Arg Leu 
                405                 410                 415     


Ala Pro Leu Pro Gly Gly Cys Ala Pro Gly Ser His Ile Arg Glu Val 
            420                 425                 430         


Pro Arg Asp 
        435 


<210>  20
<211>  401
<212>  PRT
<213>  mus musculus

<400>  20

Met Gly Ile Met Gly Ser Leu Trp Pro Trp Ile Leu Thr Met Leu Ser 
1               5                   10                  15      


Leu Leu Gly Leu Ser Met Gly Ala Pro Ser Ala Ser Arg Cys Ser Gly 
            20                  25                  30          


Val Cys Ser Thr Ser Val Pro Glu Gly Phe Thr Pro Glu Gly Ser Pro 
        35                  40                  45              


Val Phe Gln Asp Lys Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Ser 
    50                  55                  60                  


Glu Glu Thr Pro Glu Ser Ser Phe Leu Leu Ser Arg Lys Tyr Asp Glu 
65                  70                  75                  80  


Leu Ser Arg Arg Val Ile Met Asp Ala Phe Ala Glu Phe Glu Arg Phe 
                85                  90                  95      


Thr Cys Ile Arg Phe Val Ala Tyr His Gly Gln Arg Asp Phe Val Ser 
            100                 105                 110         


Ile Leu Pro Met Ala Gly Cys Phe Ser Gly Val Gly Arg Ser Gly Gly 
        115                 120                 125             


Met Gln Val Val Ser Leu Ala Pro Thr Cys Leu Arg Lys Gly Arg Gly 
    130                 135                 140                 


Ile Val Leu His Glu Leu Met His Val Leu Gly Phe Trp His Glu His 
145                 150                 155                 160 


Ser Arg Ala Asp Arg Asp Arg Tyr Ile Gln Val Asn Trp Asn Glu Ile 
                165                 170                 175     


Leu Pro Gly Phe Glu Ile Asn Phe Ile Lys Ser Arg Ser Thr Asn Met 
            180                 185                 190         


Leu Val Pro Tyr Asp Tyr Ser Ser Val Met His Tyr Gly Arg Phe Ala 
        195                 200                 205             


Phe Ser Trp Arg Gly Gln Pro Thr Ile Ile Pro Leu Trp Thr Ser Ser 
    210                 215                 220                 


Val His Ile Gly Gln Arg Trp Asn Leu Ser Thr Ser Asp Ile Thr Arg 
225                 230                 235                 240 


Val Cys Arg Leu Tyr Asn Cys Ser Arg Ser Val Pro Asp Ser His Gly 
                245                 250                 255     


Arg Gly Phe Glu Ala Gln Ser Asp Gly Ser Ser Leu Thr Pro Ala Ser 
            260                 265                 270         


Ile Ser Arg Leu Gln Arg Leu Leu Glu Ala Leu Ser Glu Glu Ser Gly 
        275                 280                 285             


Ser Ser Ala Pro Ser Gly Ser Arg Thr Gly Gly Gln Ser Ile Ala Gly 
    290                 295                 300                 


Leu Gly Asn Ser Gln Gln Gly Trp Glu His Pro Pro Gln Ser Thr Phe 
305                 310                 315                 320 


Ser Val Gly Ala Leu Ala Arg Pro Pro Gln Met Leu Ala Asp Ala Ser 
                325                 330                 335     


Lys Ser Gly Pro Gly Ala Gly Ala Asp Ser Leu Ser Leu Glu Gln Phe 
            340                 345                 350         


Gln Leu Ala Gln Ala Pro Thr Val Pro Leu Ala Leu Phe Pro Glu Ala 
        355                 360                 365             


Arg Asp Lys Pro Ala Pro Ile Gln Asp Ala Phe Glu Arg Leu Ala Pro 
    370                 375                 380                 


Leu Pro Gly Gly Cys Ala Pro Gly Ser His Ile Arg Glu Val Pro Arg 
385                 390                 395                 400 


Asp 
    


<210>  21
<211>  413
<212>  PRT
<213>  mus musculus

<400>  21

Met Gly Ile Met Gly Ser Leu Trp Pro Trp Ile Leu Thr Met Leu Ser 
1               5                   10                  15      


Leu Leu Gly Leu Ser Met Gly Ala Pro Ser Ala Ser Arg Cys Ser Gly 
            20                  25                  30          


Val Cys Ser Thr Ser Val Pro Glu Gly Phe Thr Pro Glu Gly Ser Pro 
        35                  40                  45              


Val Phe Gln Asp Lys Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Ser 
    50                  55                  60                  


Glu Glu Thr Pro Glu Ser Ser Phe Leu Val Glu Gly Asp Ile Ile Arg 
65                  70                  75                  80  


Pro Gly Val Ser His Gly Val Ser Phe Pro Asn Glu Leu Ser Arg Arg 
                85                  90                  95      


Val Ile Met Asp Ala Phe Ala Glu Phe Glu Arg Phe Thr Cys Ile Arg 
            100                 105                 110         


Phe Val Ala Tyr His Gly Gln Arg Asp Phe Val Ser Ile Leu Pro Met 
        115                 120                 125             


Ala Gly Cys Phe Ser Gly Val Gly Arg Ser Gly Gly Met Gln Val Val 
    130                 135                 140                 


Ser Leu Ala Pro Thr Cys Leu Arg Lys Gly Arg Gly Ile Val Leu His 
145                 150                 155                 160 


Glu Leu Met His Val Leu Gly Phe Trp His Glu His Ser Arg Ala Asp 
                165                 170                 175     


Arg Asp Arg Tyr Ile Gln Val Asn Trp Asn Glu Ile Leu Pro Gly Phe 
            180                 185                 190         


Glu Ile Asn Phe Ile Lys Ser Arg Ser Thr Asn Met Leu Val Pro Tyr 
        195                 200                 205             


Asp Tyr Ser Ser Val Met His Tyr Gly Arg Phe Ala Phe Ser Trp Arg 
    210                 215                 220                 


Gly Gln Pro Thr Ile Ile Pro Leu Trp Thr Ser Ser Val His Ile Gly 
225                 230                 235                 240 


Gln Arg Trp Asn Leu Ser Thr Ser Asp Ile Thr Arg Val Cys Arg Leu 
                245                 250                 255     


Tyr Asn Cys Ser Arg Ser Val Pro Asp Ser His Gly Arg Gly Phe Glu 
            260                 265                 270         


Ala Gln Ser Asp Gly Ser Ser Leu Thr Pro Ala Ser Ile Ser Arg Leu 
        275                 280                 285             


Gln Arg Leu Leu Glu Ala Leu Ser Glu Glu Ser Gly Ser Ser Ala Pro 
    290                 295                 300                 


Ser Gly Ser Arg Thr Gly Gly Gln Ser Ile Ala Gly Leu Gly Asn Ser 
305                 310                 315                 320 


Gln Gln Gly Trp Glu His Pro Pro Gln Ser Thr Phe Ser Val Gly Ala 
                325                 330                 335     


Leu Ala Arg Pro Pro Gln Met Leu Ala Asp Ala Ser Lys Ser Gly Pro 
            340                 345                 350         


Gly Ala Gly Ala Asp Ser Leu Ser Leu Glu Gln Phe Gln Leu Ala Gln 
        355                 360                 365             


Ala Pro Thr Val Pro Leu Ala Leu Phe Pro Glu Ala Arg Asp Lys Pro 
    370                 375                 380                 


Ala Pro Ile Gln Asp Ala Phe Glu Arg Leu Ala Pro Leu Pro Gly Gly 
385                 390                 395                 400 


Cys Ala Pro Gly Ser His Ile Arg Glu Val Pro Arg Asp 
                405                 410             


<210>  22
<211>  1296
<212>  DNA
<213>  homo sapiens

<400>  22
atggagggtg tagggggtct ctggccttgg gtgctgggtc tgctctcctt gccaggtgtg       60

atcctaggag cgcccctggc ctccagctgc gcaggagcct gtggtaccag cttcccagat      120

ggcctcaccc ctgagggaac ccaggcctcc ggggacaagg acattcctgc aattaaccaa      180

gggctcatcc tggaagaaac cccagagagc agcttcctca tcgaggggga catcatccgg      240

ccgagtccct tccgactgct gtcagcaacc agcaacaaat ggcccatggg tggtagtggt      300

gtcgtggagg tccccttcct gctctccagc aagtacgatg agcccagccg ccaggtcatc      360

ctggaggctc ttgcggagtt tgaacgttcc acgtgcatca ggtttgtcac ctatcaggac      420

cagagagact tcatttccat catccccatg tatgggtgct tctcgagtgt ggggcgcagt      480

ggagggatgc aggtggtctc cctggcgccc acgtgtctcc agaagggccg gggcattgtc      540

cttcatgagc tcatgcatgt gctgggcttc tggcacgagc acacgcgggc cgaccgggac      600

cgctatatcc gtgtcaactg gaacgagatc ctgccaggct ttgaaatcaa cttcatcaag      660

tctcagagca gcaacatgct gacgccctat gactactcct ctgtgatgca ctatgggagg      720

ctcgccttca gccggcgtgg gctgcccacc atcacaccac tttgggcccc cagtgtccac      780

atcggccagc gatggaacct gagtgcctcg gacatcaccc gggtcctcaa actctacggc      840

tgcagcccaa gtggccccag gccccgtggg agagggtccc atgcccacag cactggtagg      900

agccccgctc cggcctccct atctctgcag cggcttttgg aggcactgtc ggcggaatcc      960

aggagccccg accccagtgg ttccagtgcg ggaggccagc ccgttcctgc agggcctggg     1020

gagagcccac atgggtggga gtcccctgcc ctgaaaaagc tcagtgcaga ggcctcggca     1080

aggcagcctc agaccctagc ttcctcccca agatcaaggc ctggagcagg tgcccccggt     1140

gttgctcagg agcagtcctg gctggccgga gtgtccacca agcccacagt cccatcttca     1200

gaagcaggaa tccagccagt ccctgtccag ggaagcccag ctctgccagg gggctgtgta     1260

cctagaaatc atttcaaggg gatgtccgaa gattaa                               1296


<210>  23
<211>  431
<212>  PRT
<213>  homo sapiens

<400>  23

Met Glu Gly Val Gly Gly Leu Trp Pro Trp Val Leu Gly Leu Leu Ser 
1               5                   10                  15      


Leu Pro Gly Val Ile Leu Gly Ala Pro Leu Ala Ser Ser Cys Ala Gly 
            20                  25                  30          


Ala Cys Gly Thr Ser Phe Pro Asp Gly Leu Thr Pro Glu Gly Thr Gln 
        35                  40                  45              


Ala Ser Gly Asp Lys Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Leu 
    50                  55                  60                  


Glu Glu Thr Pro Glu Ser Ser Phe Leu Ile Glu Gly Asp Ile Ile Arg 
65                  70                  75                  80  


Pro Ser Pro Phe Arg Leu Leu Ser Ala Thr Ser Asn Lys Trp Pro Met 
                85                  90                  95      


Gly Gly Ser Gly Val Val Glu Val Pro Phe Leu Leu Ser Ser Lys Tyr 
            100                 105                 110         


Asp Glu Pro Ser Arg Gln Val Ile Leu Glu Ala Leu Ala Glu Phe Glu 
        115                 120                 125             


Arg Ser Thr Cys Ile Arg Phe Val Thr Tyr Gln Asp Gln Arg Asp Phe 
    130                 135                 140                 


Ile Ser Ile Ile Pro Met Tyr Gly Cys Phe Ser Ser Val Gly Arg Ser 
145                 150                 155                 160 


Gly Gly Met Gln Val Val Ser Leu Ala Pro Thr Cys Leu Gln Lys Gly 
                165                 170                 175     


Arg Gly Ile Val Leu His Glu Leu Met His Val Leu Gly Phe Trp His 
            180                 185                 190         


Glu His Thr Arg Ala Asp Arg Asp Arg Tyr Ile Arg Val Asn Trp Asn 
        195                 200                 205             


Glu Ile Leu Pro Gly Phe Glu Ile Asn Phe Ile Lys Ser Gln Ser Ser 
    210                 215                 220                 


Asn Met Leu Thr Pro Tyr Asp Tyr Ser Ser Val Met His Tyr Gly Arg 
225                 230                 235                 240 


Leu Ala Phe Ser Arg Arg Gly Leu Pro Thr Ile Thr Pro Leu Trp Ala 
                245                 250                 255     


Pro Ser Val His Ile Gly Gln Arg Trp Asn Leu Ser Ala Ser Asp Ile 
            260                 265                 270         


Thr Arg Val Leu Lys Leu Tyr Gly Cys Ser Pro Ser Gly Pro Arg Pro 
        275                 280                 285             


Arg Gly Arg Gly Ser His Ala His Ser Thr Gly Arg Ser Pro Ala Pro 
    290                 295                 300                 


Ala Ser Leu Ser Leu Gln Arg Leu Leu Glu Ala Leu Ser Ala Glu Ser 
305                 310                 315                 320 


Arg Ser Pro Asp Pro Ser Gly Ser Ser Ala Gly Gly Gln Pro Val Pro 
                325                 330                 335     


Ala Gly Pro Gly Glu Ser Pro His Gly Trp Glu Ser Pro Ala Leu Lys 
            340                 345                 350         


Lys Leu Ser Ala Glu Ala Ser Ala Arg Gln Pro Gln Thr Leu Ala Ser 
        355                 360                 365             


Ser Pro Arg Ser Arg Pro Gly Ala Gly Ala Pro Gly Val Ala Gln Glu 
    370                 375                 380                 


Gln Ser Trp Leu Ala Gly Val Ser Thr Lys Pro Thr Val Pro Ser Ser 
385                 390                 395                 400 


Glu Ala Gly Ile Gln Pro Val Pro Val Gln Gly Ser Pro Ala Leu Pro 
                405                 410                 415     


Gly Gly Cys Val Pro Arg Asn His Phe Lys Gly Met Ser Glu Asp 
            420                 425                 430     


<210>  24
<211>  11
<212>  PRT
<213>  mus musculus

<400>  24

His Glu Leu Met His Val Leu Gly Phe Trp His 
1               5                   10      


<210>  25
<211>  5
<212>  PRT
<213>  mus musculus

<400>  25

Ser Val Met His Tyr 
1               5   


<210>  26
<211>  11
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  The X represents possible amino acid residue substitution with 
       other amino acids

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

His Glu Xaa Xaa His Xaa Xaa Gly Xaa Xaa His 
1               5                   10      


<210>  27
<211>  5
<212>  PRT
<213>  mus musculus


<220>
<221>  UNSURE
<222>  (1)..(5)
<223>  X indicates the site of possible amino acid substitution

<400>  27

Ser Xaa Met His Tyr 
1               5   


<210>  28
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  28
gcgcccctgg cctccagctg cgca                                              24


<210>  29
<211>  24
<212>  DNA
<213>  homo sapiens

<400>  29
cacgacacca ctaccaccca tggg                                              24


<210>  30
<211>  24
<212>  DNA
<213>  homo sapiens

<400>  30
ggctgcagcc caagtggccc cagg                                              24


<210>  31
<211>  24
<212>  DNA
<213>  homo sapiens

<400>  31
agcaacaccg ggggcacctg ctcc                                              24


<210>  32
<211>  24
<212>  DNA
<213>  homo sapiens

<400>  32
gaggtcccct tcctgctctc cagc                                              24


<210>  33
<211>  24
<212>  DNA
<213>  homo sapiens

<400>  33
ggcatgggac cctctcccac gggg                                              24


