
                                SEQUENCE LISTING

<110> Ho, David
      Olafsen, Tove
      Romero, Jason
      Behrenbruch, Christian


<120> ANTIGEN BINDING CONSTRUCTS TO CD3
  

<130> IGNAB.015WO

<150> US 61/660,594
<151> 2012-06-15

<150> US 61/674,229
<151> 2012-07-20

<150> US 61/776,673
<151> 2013-03-11


<160> 125

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 106
<212> PRT
<213> Mus musculus

<400> 1
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn
            100                 105     


<210> 2
<211> 108
<212> PRT
<213> Homo sapiens

<400> 2
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
                85                  90                  95      
Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 3
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 3
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105     


<210> 4
<211> 119
<212> PRT
<213> Mus musculus

<400> 4
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 5
<211> 115
<212> PRT
<213> Homo sapiens

<400> 5
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 6
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 7
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 7
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser
            20                  25                  30          
Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly
                85                  90                  95      
Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Ser
        115                 120                 125             
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
    130                 135                 140                 
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
145                 150                 155                 160 
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                165                 170                 175     
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
            180                 185                 190         
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
        195                 200                 205             
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
    210                 215                 220                 
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Thr Leu Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 8
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 8
atggaaaccg acactctgct gctgtgggtc ctgctgctgt gggtgcccgg atcaactgga 60
cagatcgtgc tgactcagtc tcccgctatc atgtctgcct cacctggcga aaaagtgaca 120
atgacctgtt ccgcctcttc ttccgtgtct tacatgaatt ggtaccagca gaaatctggg 180
actagtccta aacggtggat ctacgatact agcaaactgg cttctggcgt gcctgctcat 240
ttccgtggtt ctggctctgg aacctcttac tctctgacca tctctggcat ggaggccgag 300
gatgccgcca cctactactg ccagcagtgg agttcaaacc ctttcacatt cggctccggc 360
acaaaactgg agatcaacgg ctctactagt ggtggaggat ctggtggtgg atctggaggg 420
ggcggatcat ctcaggtcca gctgcagcag tctggtgctg aactggcacg tcctggtgcc 480
tccgtgaaaa tgtcttgtaa ggcctctggt tacaccttta cccggtacac tatgcattgg 540
gtcaaacagc gccctgggca gggactggaa tggattggct acatcaaccc ttctcgtggc 600
tacacaaact acaatcagaa attcaaggac aaggccaccc tgacaaccga caaatcttct 660
tcaaccgcct acatgcagct gtcatccctg acctctgagg atagtgctgt gtactactgt 720
gctcggtact acgacgatca ctactgtctg gactactggg gacagggaac aacactgact 780
gtgtcctccg aacccaaatc ctgtgacaaa acccacacct gtccaccttg tggcggtgga 840
tcatctggcg gagggagtgg agggcagcct agggagcctc aggtctacac actgccacct 900
tctcgggacg aactgacaaa aaaccaggtg tccctgacat gtctggtgaa gggcttctac 960
ccttccgata tcgctgtgga gtgggagtca aatggccagc ccgaaaacaa ctacaaaacc 1020
accccacctg tgctggattc cgatggctct ttcttcctgt actctaaact gaccgtggat 1080
aagagtcgat ggcagcaggg aaacgtgttc tcttgctccg tgatgcacga ggccctgcat 1140
aatcattaca cccagaaatc actgtctctg tcacccggca aatga                 1185

<210> 9
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 9
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Ser
        115                 120                 125             
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
    130                 135                 140                 
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                165                 170                 175     
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
            180                 185                 190         
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
        195                 200                 205             
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
    210                 215                 220                 
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
225                 230                 235                 240 
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Pro Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 10
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 10
atggaaaccg acactctgct gctgtgggtc ctgctgctgt gggtgcccgg atcaactggt 60
gacatccaga tgacacagtc tccctcttct ctgtccgcct ctgtgggcga tcgagtgaca 120
atcacctgta gcgcttcatc ctccgtgtct tacatgaatt ggtaccagca gacccctggc 180
aaagctccta aacgatggat ctacgacacc tccaaactgg cttccggcgt gccttcacga 240
ttttctggtt ctggttctgg gaccgactac acctttacca tctcatcact gcagcctgag 300
gatatcgcca catactactg tcagcagtgg tctagcaacc ctttcacatt cgggcagggc 360
acaaaactgc agatcaccgg ctcaacctct ggcggtggct ctggcggcgg tagtggtggt 420
ggtggttcta gtcaggtcca gctggtccag tctggtggag gagtggtcca gcccgggaga 480
tcactgaggc tgtcctgtaa ggctagtggc tacactttta cacggtacac catgcattgg 540
gtgaggcagg cacctgggaa aggcctggaa tggatcggat acatcaaccc tagtagggga 600
tacacaaact acaatcagaa agtcaaggac cggttcacaa tctctaggga caactctaaa 660
aacaccgctt ttctgcagat ggactcactg aggcctgagg acactggagt gtacttttgt 720
gctcggtact acgatgatca ttactgcctg gattactggg gacaggggac acctgtcact 780
gtctcttccg aacccaaatc ttgtgacaaa acccacacat gccctccatg tggtggcgga 840
tcctctggtg gcggttctgg ggggcagcct agggaacctc aggtgtacac actgccacct 900
tctcgtgacg aactgaccaa aaaccaggtg tcactgacct gtctggtcaa gggcttttac 960
ccttccgaca ttgctgtgga gtgggagtca aatggccagc ctgaaaacaa ctacaaaacc 1020
acaccccccg tcctggattc cgatggctct ttcttcctgt actctaaact gaccgtcgac 1080
aaatctcgat ggcagcaggg aaacgtgttc tcttgttccg tcatgcacga ggctctgcac 1140
aatcactaca cacagaaatc actgagcctg agccctggaa aatga                 1185

<210> 11
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 11
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Ser
        115                 120                 125             
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
    130                 135                 140                 
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                165                 170                 175     
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
            180                 185                 190         
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
        195                 200                 205             
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
    210                 215                 220                 
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
225                 230                 235                 240 
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Pro Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 12
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 12
atggaaaccg acactctgct gctgtgggtc ctgctgctgt gggtgcccgg atcaactggt 60
gacatccaga tgacacagtc tccctcttct ctgtccgcct ctgtgggcga tcgagtgaca 120
atcacctgta gcgcttcatc ctccgtgtct tacatgaatt ggtaccagca gacccctggc 180
aaagctccta aacgatggat ctacgacacc tccaaactgg cttccggcgt gccttcacga 240
ttttctggtt ctggttctgg gaccgactac acctttacca tctcatcact gcagcctgag 300
gatatcgcca catactactg tcagcagtgg tctagcaacc ctttcacatt cgggcagggc 360
acaaaactgc agatcaccgg ctcaacctct ggcggtggct ctggcggcgg tagtggtggt 420
ggtggttcta gtcaggtcca gctggtccag tctggtggag gagtggtcca gcccgggaga 480
tcactgaggc tgtcctgtaa ggctagtggc tacactttta cacggtacac catgcattgg 540
gtgaggcagg cacctgggaa aggcctggaa tggatcggat acatcaaccc tagtagggga 600
tacacaaact acaatcagaa agtcaaggac cggttcacaa tctctaggga caactctaaa 660
aacaccgctt ttctgcagat ggactcactg aggcctgagg acactggagt gtacttttgt 720
gctcggtact acgatgatca ttactgcctg gattactggg gacaggggac acctgtcact 780
gtctcttccg aacccaaatc ttgtgacaaa acccacacat gccctccatg tggtggcgga 840
tcctctggtg gcggttctgg ggggcagcct agggaacctc aggtgtacac actgccacct 900
tctcgtgacg aactgaccaa aaaccaggtg tcactgacct gtctggtcaa gggcttttac 960
ccttccgaca ttgctgtgga gtgggagtca aatggccagc ctgaaaacaa ctacaaaacc 1020
acaccccccg tcctggattc cgatggctct ttcttcctgt actctaaact gaccgtcgac 1080
aaatctcgat ggcagcaggg aaacgtgttc tcttgttccg tcatgcacga ggctctgcac 1140
aatcactaca cacagaaatc actgagcctg agccctggaa aatga                 1185

<210> 13
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 13
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
    50                  55                  60                  
Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
                85                  90                  95      
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly
        115                 120                 125             
Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145                 150                 155                 160 
Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
                165                 170                 175     
Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn
            180                 185                 190         
Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 14
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 14
atggaaaccg acactctgct gctgtgggtc ctgctgctgt gggtgcccgg atcaactgga 60
gaaatcgtgc tgactcagtc ccctgctaca ctgtctctgt cacctggcga acgagcaaca 120
ctgtcctgtt ctgcctcttc ttctgtctca tacatgaact ggtaccagca gaaacctgga 180
caggctccta gactgctgat ctacgacacc tctaaactgg catctggcgt gcccgctcat 240
tttcgtggct ctggatctgg aaccgacttt accctgacca tctcttccct ggaacctgag 300
gattttgccg tgtactactg ccagcagtgg tctagtaacc ctttcacttt tggccagggc 360
actaaagtgg agatcaaatc cggtggtggc ggacaggtcc agctggtcca gagtggagct 420
gaggtgaaaa aacccggcgc ttccgtcaaa gtctcctgta aggctagcgg atacacattc 480
acacgctaca ccatgcattg ggtccggcag gctcccggac agggcctgga atggatggga 540
tacatcaacc cttctcgggg ctacacaaac tacaaccaga aattcaagga tcgagtgacc 600
atgacaaccg acactagcat ctctaccgcc tacatggaac tgagccggct gagatccgat 660
gataccgctg tctactactg tgctcggtac tacgatgatc attactgcct ggattactgg 720
gggcagggca cactggtgac tgtgagttcc ggaggatgt                        759

<210> 15
<211> 435
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 15
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Met Asp Trp Val Trp Thr Leu Leu Phe Leu Leu Ser
            20                  25                  30          
Val Thr Ala Gly Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala
        35                  40                  45              
Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser
    50                  55                  60                  
Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro
65                  70                  75                  80  
Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr
                85                  90                  95      
Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp
            100                 105                 110         
Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu
        115                 120                 125             
Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys
    130                 135                 140                 
Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Ser
145                 150                 155                 160 
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
                165                 170                 175     
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser
            180                 185                 190         
Val Ile Ile Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile
        195                 200                 205             
Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser
    210                 215                 220                 
Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser
225                 230                 235                 240 
Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro
                245                 250                 255     
Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile
            260                 265                 270         
Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp
        275                 280                 285             
Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn
    290                 295                 300                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
305                 310                 315                 320 
Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val
                325                 330                 335     
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            340                 345                 350         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        355                 360                 365             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    370                 375                 380                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
385                 390                 395                 400 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                405                 410                 415     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            420                 425                 430         
Pro Gly Lys
        435 


<210> 16
<211> 1308
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 16
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
atggattggg tgtggacctt gctattcctg ttgtcagtaa ctgcaggtgt ccactcccag 120
gtccagctgc agcagtctgg ggctgaactg gcaagacctg gggcctcagt gaagatgtcc 180
tgcaaggctt ctggctacac ctttactagg tacacgatgc actgggtaaa acagaggcct 240
ggacagggtc tggaatggat tggatacatt aatcctagcc gtggttatac taattacaat 300
cagaagttca aggacaaggc cacattgact acagacaaat cctccagcac agcctacatg 360
caactgagca gcctgacatc tgaggactct gcagtctatt actgtgcaag atattatgat 420
gatcattact gccttgacta ctggggccaa ggcaccactc tcacagtctc ctcaggctcc 480
acatccggcg gaggctctgg cggtggatct ggcggaggcg gctcatccat ggattttcaa 540
gtgcagattt tcagcttcct gctaatcagt gcctcagtca taatatccag aggacaaatt 600
gttctcaccc agtctccagc aatcatgtct gcatctccag gggagaaggt caccatgacc 660
tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagtc aggcacctcc 720
cccaaaagat ggatttatga cacatccaaa ctggcttctg gagtccctgc tcacttcagg 780
ggcagtgggt ctgggacctc ttactctctc acaatcagcg gcatggaggc tgaagatgct 840
gccacttatt actgccagca gtggagtagt aacccattca cgttcggctc ggggacaaag 900
ttggaaataa acgagcctaa gtcctgcgac aagacccaca cctgtccccc ttgcggcgga 960
ggaagcagcg gaggcggatc cggtggccag cctcgggagc ctcaggtgta caccctgcct 1020
ccctcccggg acgagctgac caagaaccag gtgtccctga cctgtctggt caagggcttc 1080
tacccttccg atatcgccgt ggagtgggag tccaacggcc agcctgagaa caactacaag 1140
accacccctc ctgtgctgga ctccgacggc tccttcttcc tgtactccaa gctcacagtg 1200
gataagtccc ggtggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg 1260
cacaaccact atacccagaa gtccctgtcc ctgtctcctg gcaagtga              1308

<210> 17
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 17
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser
            20                  25                  30          
Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly
                85                  90                  95      
Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Ser Gly
        115                 120                 125             
Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145                 150                 155                 160 
Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu
                165                 170                 175     
Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn
            180                 185                 190         
Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser
        195                 200                 205             
Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 18
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 18
atggaaaccg acaccctgct gctgtgggtc ctgctcctct gggtgccagg ctctaccggc 60
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc 120
atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc 180
acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac 240
ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa 300
gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg 360
acaaagttgg aaataaactc tggtggaggc gggcaggtcc agctgcagca gtctggggct 420
gaactggcaa gacctggggc ctcagtgaag atgtcctgca aggcttctgg ctacaccttt 480
actaggtaca cgatgcactg ggtaaaacag aggcctggac agggtctgga atggattgga 540
tacattaatc ctagccgtgg ttatactaat tacaatcaga agttcaagga caaggccaca 600
ttgactacag acaaatcctc cagcacagcc tacatgcaac tgagcagcct gacatctgag 660
gactctgcag tctattactg tgcaagatat tatgatgatc attactgcct tgactactgg 720
ggccaaggca ccactctcac agtctcctca ggcggatgct ga                    762

<210> 19
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 19
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala
            20                  25                  30          
Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser
                85                  90                  95      
Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
145                 150                 155                 160 
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                165                 170                 175     
Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
            180                 185                 190         
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu
    210                 215                 220                 
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
225                 230                 235                 240 
Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly Cys
                245                 250             


<210> 20
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 20
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg 120
tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg 180
cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac 240
aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac 300
atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat 360
gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctcaagt 420
ggtggaggag gccaaattgt tctcacccag tctccagcaa tcatgtctgc atctccaggg 480
gagaaggtca ccatgacctg cagtgccagc tcaagtgtaa gttacatgaa ctggtaccag 540
cagaagtcag gcacctcccc caaaagatgg atttatgaca catccaaact ggcttctgga 600
gtccctgctc acttcagggg cagtgggtct gggacctctt actctctcac aatcagcggc 660
atggaggctg aagatgctgc cacttattac tgccagcagt ggagtagtaa cccattcacg 720
ttcggctcgg ggacaaagtt ggaaataaac ggcggctgc                        759

<210> 21
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 21
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser
            20                  25                  30          
Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly
                85                  90                  95      
Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
    130                 135                 140                 
Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly
145                 150                 155                 160 
Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly
                165                 170                 175     
Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr
            180                 185                 190         
Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys
        195                 200                 205             
Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
    210                 215                 220                 
Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu
225                 230                 235                 240 
Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Cys
                245                 250                 255     


<210> 22
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 22
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc 120
atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc 180
acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac 240
ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa 300
gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg 360
acaaagttgg aaataaacgg cggagggagt ggcggaggcg gccaggtcca gctgcagcag 420
tctggggctg aactggcaag acctggggcc tcagtgaaga tgtcctgcaa ggcttctggc 480
tacaccttta ctaggtacac gatgcactgg gtaaaacaga ggcctggaca gggtctggaa 540
tggattggat acattaatcc tagccgtggt tatactaatt acaatcagaa gttcaaggac 600
aaggccacat tgactacaga caaatcctcc agcacagcct acatgcaact gagcagcctg 660
acatctgagg actctgcagt ctattactgt gcaagatatt atgatgatca ttactgcctt 720
gactactggg gccaaggcac cactctcaca gtctcctcag gcggctgc              768

<210> 23
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 23
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala
            20                  25                  30          
Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser
                85                  90                  95      
Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala
145                 150                 155                 160 
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val
                165                 170                 175     
Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg
            180                 185                 190         
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe
        195                 200                 205             
Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met
    210                 215                 220                 
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn
225                 230                 235                 240 
Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly Cys
                245                 250                 255     


<210> 24
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 24
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg 120
tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg 180
cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac 240
aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac 300
atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat 360
gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctcaggc 420
ggagggagtg gcggaggcgg ccaaattgtt ctcacccagt ctccagcaat catgtctgca 480
tctccagggg agaaggtcac catgacctgc agtgccagct caagtgtaag ttacatgaac 540
tggtaccagc agaagtcagg cacctccccc aaaagatgga tttatgacac atccaaactg 600
gcttctggag tccctgctca cttcaggggc agtgggtctg ggacctctta ctctctcaca 660
atcagcggca tggaggctga agatgctgcc acttattact gccagcagtg gagtagtaac 720
ccattcacgt tcggctcggg gacaaagttg gaaataaacg gcggctgc              768

<210> 25
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 25
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly
            100                 105                 110         
Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Ser Thr Ser Gly
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln
145                 150                 155                 160 
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                165                 170                 175     
Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr
            180                 185                 190         
Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser
        195                 200                 205             
Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
225                 230                 235                 240 
Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln
                245                 250                 255     
Gly Thr Lys Leu Gln Ile Thr Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 26
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 26
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagtc tggtggagga gtggtccagc ccgggagatc actgaggctg 120
tcctgtaagg ctagtggcta cacttttaca cggtacacca tgcattgggt gaggcaggca 180
cctgggaaag gcctggaatg gatcggatac atcaacccta gtaggggata cacaaactac 240
aatcagaaag tcaaggaccg gttcacaatc tctagggaca actctaaaaa caccgctttt 300
ctgcagatgg actcactgag gcctgaggac actggagtgt acttttgtgc tcggtactac 360
gatgatcatt actgcctgga ttactgggga caggggacac ctgtcactgt ctcttccggc 420
tccacatccg gcggaggctc tggcggtgga tctggcggag gcggctcatc cgacatccag 480
atgacacagt ctccctcttc tctgtccgcc tctgtgggcg atcgagtgac aatcacctgt 540
agcgcttcat cctccgtgtc ttacatgaat tggtaccagc agacccctgg caaagctcct 600
aaacgatgga tctacgacac ctccaaactg gcttccggcg tgccttcacg attttctggt 660
tctggttctg ggaccgacta cacctttacc atctcatcac tgcagcctga ggatatcgcc 720
acatactact gtcagcagtg gtctagcaac cctttcacat tcgggcaggg cacaaaactg 780
cagatcaccg agcctaagtc ctgcgacaag acccacacct gtcccccttg cggcggagga 840
agcagcggag gcggatccgg tggccagcct cgggagcctc aggtgtacac cctgcctccc 900
tcccgggacg agctgaccaa gaaccaggtg tccctgacct gtctggtcaa gggcttctac 960
ccttccgata tcgccgtgga gtgggagtcc aacggccagc ctgagaacaa ctacaagacc 1020
acccctcctg tgctggactc cgacggctcc ttcttcctgt actccaagct cacagtggat 1080
aagtcccggt ggcagcaggg caacgtgttc tcctgctccg tgatgcacga ggccctgcac 1140
aaccactata cccagaagtc cctgtccctg tctcctggca agtga                 1185

<210> 27
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 27
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Ser Gly
        115                 120                 125             
Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln
    130                 135                 140                 
Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145                 150                 155                 160 
Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                165                 170                 175     
Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn
            180                 185                 190         
Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
        195                 200                 205             
Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val
    210                 215                 220                 
Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 28
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 28
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccaga tgacacagtc tccctcttct ctgtccgcct ctgtgggcga tcgagtgaca 120
atcacctgta gcgcttcatc ctccgtgtct tacatgaatt ggtaccagca gacccctggc 180
aaagctccta aacgatggat ctacgacacc tccaaactgg cttccggcgt gccttcacga 240
ttttctggtt ctggttctgg gaccgactac acctttacca tctcatcact gcagcctgag 300
gatatcgcca catactactg tcagcagtgg tctagcaacc ctttcacatt cgggcagggc 360
acaaaactgc agatcaccag tggtggagga ggccaggtcc agctggtcca gtctggtgga 420
ggagtggtcc agcccgggag atcactgagg ctgtcctgta aggctagtgg ctacactttt 480
acacggtaca ccatgcattg ggtgaggcag gcacctggga aaggcctgga atggatcgga 540
tacatcaacc ctagtagggg atacacaaac tacaatcaga aagtcaagga ccggttcaca 600
atctctaggg acaactctaa aaacaccgct tttctgcaga tggactcact gaggcctgag 660
gacactggag tgtacttttg tgctcggtac tacgatgatc attactgcct ggattactgg 720
ggacagggga cacctgtcac tgtctcttcc ggcggctgc                        759

<210> 29
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 29
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly
            100                 105                 110         
Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
145                 150                 155                 160 
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                165                 170                 175     
Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
            180                 185                 190         
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
    210                 215                 220                 
Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
225                 230                 235                 240 
Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Gly Cys
                245                 250             


<210> 30
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 30
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagtc tggtggagga gtggtccagc ccgggagatc actgaggctg 120
tcctgtaagg ctagtggcta cacttttaca cggtacacca tgcattgggt gaggcaggca 180
cctgggaaag gcctggaatg gatcggatac atcaacccta gtaggggata cacaaactac 240
aatcagaaag tcaaggaccg gttcacaatc tctagggaca actctaaaaa caccgctttt 300
ctgcagatgg actcactgag gcctgaggac actggagtgt acttttgtgc tcggtactac 360
gatgatcatt actgcctgga ttactgggga caggggacac ctgtcactgt ctcttccagt 420
ggtggaggag gcgacatcca gatgacacag tctccctctt ctctgtccgc ctctgtgggc 480
gatcgagtga caatcacctg tagcgcttca tcctccgtgt cttacatgaa ttggtaccag 540
cagacccctg gcaaagctcc taaacgatgg atctacgaca cctccaaact ggcttccggc 600
gtgccttcac gattttctgg ttctggttct gggaccgact acacctttac catctcatca 660
ctgcagcctg aggatatcgc cacatactac tgtcagcagt ggtctagcaa ccctttcaca 720
ttcgggcagg gcacaaaact gcagatcacc ggcggctgc                        759

<210> 31
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 31
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly
    130                 135                 140                 
Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly
145                 150                 155                 160 
Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly
                165                 170                 175     
Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr
            180                 185                 190         
Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn
        195                 200                 205             
Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp
    210                 215                 220                 
Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu
225                 230                 235                 240 
Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Cys
                245                 250                 255     


<210> 32
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 32
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccaga tgacacagtc tccctcttct ctgtccgcct ctgtgggcga tcgagtgaca 120
atcacctgta gcgcttcatc ctccgtgtct tacatgaatt ggtaccagca gacccctggc 180
aaagctccta aacgatggat ctacgacacc tccaaactgg cttccggcgt gccttcacga 240
ttttctggtt ctggttctgg gaccgactac acctttacca tctcatcact gcagcctgag 300
gatatcgcca catactactg tcagcagtgg tctagcaacc ctttcacatt cgggcagggc 360
acaaaactgc agatcaccgg cggagggagt ggcggaggcg gccaggtcca gctggtccag 420
tctggtggag gagtggtcca gcccgggaga tcactgaggc tgtcctgtaa ggctagtggc 480
tacactttta cacggtacac catgcattgg gtgaggcagg cacctgggaa aggcctggaa 540
tggatcggat acatcaaccc tagtagggga tacacaaact acaatcagaa agtcaaggac 600
cggttcacaa tctctaggga caactctaaa aacaccgctt ttctgcagat ggactcactg 660
aggcctgagg acactggagt gtacttttgt gctcggtact acgatgatca ttactgcctg 720
gattactggg gacaggggac acctgtcact gtctcttccg gcggctgc              768

<210> 33
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 33
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly
            100                 105                 110         
Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
145                 150                 155                 160 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val
                165                 170                 175     
Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg
            180                 185                 190         
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe
        195                 200                 205             
Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu
    210                 215                 220                 
Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn
225                 230                 235                 240 
Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Gly Cys
                245                 250                 255     


<210> 34
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 34
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagtc tggtggagga gtggtccagc ccgggagatc actgaggctg 120
tcctgtaagg ctagtggcta cacttttaca cggtacacca tgcattgggt gaggcaggca 180
cctgggaaag gcctggaatg gatcggatac atcaacccta gtaggggata cacaaactac 240
aatcagaaag tcaaggaccg gttcacaatc tctagggaca actctaaaaa caccgctttt 300
ctgcagatgg actcactgag gcctgaggac actggagtgt acttttgtgc tcggtactac 360
gatgatcatt actgcctgga ttactgggga caggggacac ctgtcactgt ctcttccggc 420
ggagggagtg gcggaggcgg cgacatccag atgacacagt ctccctcttc tctgtccgcc 480
tctgtgggcg atcgagtgac aatcacctgt agcgcttcat cctccgtgtc ttacatgaat 540
tggtaccagc agacccctgg caaagctcct aaacgatgga tctacgacac ctccaaactg 600
gcttccggcg tgccttcacg attttctggt tctggttctg ggaccgacta cacctttacc 660
atctcatcac tgcagcctga ggatatcgcc acatactact gtcagcagtg gtctagcaac 720
cctttcacat tcgggcaggg cacaaaactg cagatcaccg gcggctgc              768

<210> 35
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 35
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile
                85                  90                  95      
Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val
145                 150                 155                 160 
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
                165                 170                 175     
Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr
            180                 185                 190         
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser
        195                 200                 205             
Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala
225                 230                 235                 240 
Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln
                245                 250                 255     
Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 36
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 36
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagag tggagctgag gtgaaaaaac ccggcgcttc cgtcaaagtc 120
tcctgtaagg ctagcggata cacctttact cgctacacca tgcattgggt ccggcaggct 180
cccggacagg gcctggaatg gatgggatac atcaaccctt ctcggggcta cacaaactac 240
aatcagaaat tcaaggatcg agtgaccatg acaaccgaca cttcaatctc taccgcttac 300
atggaactgt ctcggctgag gagtgacgat accgctgtct actactgtgc tcggtactac 360
gacgaccatt actgcctgga ttactggggg cagggcacac tggtgactgt gtctagcggc 420
tccacatccg gcggaggctc tggcggtgga tctggcggag gcggctcatc cgaaatcgtg 480
ctgactcagt cccctgctac actgtctctg tcacctggcg aacgagcaac actgtcctgt 540
tctgcctctt cttctgtctc atacatgaac tggtaccagc agaaacctgg acaggctcct 600
agactgctga tctacgacac ctctaaactg gcatctggcg tgcccgctca ttttcgtggc 660
tctggatctg gaaccgactt taccctgacc atctcttccc tggaacctga ggattttgcc 720
gtgtactact gccagcagtg gtctagtaac cctttcactt ttggccaggg cactaaagtg 780
gagatcaagg agcctaagtc ctgcgacaag acccacacct gtcccccttg cggcggagga 840
agcagcggag gcggatccgg tggccagcct cgggagcctc aggtgtacac cctgcctccc 900
tcccgggacg agctgaccaa gaaccaggtg tccctgacct gtctggtcaa gggcttctac 960
ccttccgata tcgccgtgga gtgggagtcc aacggccagc ctgagaacaa ctacaagacc 1020
acccctcctg tgctggactc cgacggctcc ttcttcctgt actccaagct cacagtggat 1080
aagtcccggt ggcagcaggg caacgtgttc tcctgctccg tgatgcacga ggccctgcac 1140
aaccactata cccagaagtc cctgtccctg tctcctggca agtga                 1185

<210> 37
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 37
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
    50                  55                  60                  
Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
                85                  90                  95      
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly
        115                 120                 125             
Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145                 150                 155                 160 
Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
                165                 170                 175     
Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn
            180                 185                 190         
Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 38
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 38
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaatcgtgc tgactcagtc ccctgctaca ctgtctctgt cacctggcga acgagcaaca 120
ctgtcctgtt ctgcctcttc ttctgtctca tacatgaact ggtaccagca gaaacctgga 180
caggctccta gactgctgat ctacgacacc tctaaactgg catctggcgt gcccgctcat 240
tttcgtggct ctggatctgg aaccgacttt accctgacca tctcttccct ggaacctgag 300
gattttgccg tgtactactg ccagcagtgg tctagtaacc ctttcacttt tggccagggc 360
actaaagtgg agatcaagag tggtggagga ggccaggtcc agctggtcca gagtggagct 420
gaggtgaaaa aacccggcgc ttccgtcaaa gtctcctgta aggctagcgg atacaccttt 480
actcgctaca ccatgcattg ggtccggcag gctcccggac agggcctgga atggatggga 540
tacatcaacc cttctcgggg ctacacaaac tacaatcaga aattcaagga tcgagtgacc 600
atgacaaccg acacttcaat ctctaccgct tacatggaac tgtctcggct gaggagtgac 660
gataccgctg tctactactg tgctcggtac tacgacgacc attactgcct ggattactgg 720
gggcagggca cactggtgac tgtgtctagc ggcggctgc                        759

<210> 39
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 39
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile
                85                  90                  95      
Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
145                 150                 155                 160 
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                165                 170                 175     
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
            180                 185                 190         
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
    210                 215                 220                 
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
225                 230                 235                 240 
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250             


<210> 40
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 40
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagag tggagctgag gtgaaaaaac ccggcgcttc cgtcaaagtc 120
tcctgtaagg ctagcggata cacctttact cgctacacca tgcattgggt ccggcaggct 180
cccggacagg gcctggaatg gatgggatac atcaaccctt ctcggggcta cacaaactac 240
aatcagaaat tcaaggatcg agtgaccatg acaaccgaca cttcaatctc taccgcttac 300
atggaactgt ctcggctgag gagtgacgat accgctgtct actactgtgc tcggtactac 360
gacgaccatt actgcctgga ttactggggg cagggcacac tggtgactgt gtctagcagt 420
ggtggaggag gcgaaatcgt gctgactcag tcccctgcta cactgtctct gtcacctggc 480
gaacgagcaa cactgtcctg ttctgcctct tcttctgtct catacatgaa ctggtaccag 540
cagaaacctg gacaggctcc tagactgctg atctacgaca cctctaaact ggcatctggc 600
gtgcccgctc attttcgtgg ctctggatct ggaaccgact ttaccctgac catctcttcc 660
ctggaacctg aggattttgc cgtgtactac tgccagcagt ggtctagtaa ccctttcact 720
tttggccagg gcactaaagt ggagatcaag ggcggctgc                        759

<210> 41
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 41
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly
            100                 105                 110         
Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
        115                 120                 125             
Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
    130                 135                 140                 
Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
145                 150                 155                 160 
Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln
                165                 170                 175     
Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr
            180                 185                 190         
Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr
        195                 200                 205             
Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly
    210                 215                 220                 
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
225                 230                 235     


<210> 42
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 42
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaatcgtgc tgactcagtc ccctgctaca ctgtctctgt cacctggcga acgagcaaca 120
ctgtcctgtt ctgcctcttc ttctgtctca tacatgaact ggtaccagca gaaacctgga 180
caggctccta gactgctgat ctacgacacc tctaaactgg catctggcgt gcccgctcat 240
tttcgtggct ctggatctgg aaccgacttt accctgacca tctcttccct ggaacctgag 300
gattttgccg tgtactactg ccagcagtgg tctagtaacc ctttcacttt tggccagggc 360
actaaagtgg agatcaaggg cggagggagt ggcggaggcg gccaggtcca gctggtccag 420
agtggagctg aggtgaaaaa acccggcgct tccgtcaaag tctcctgtaa ggctagcgga 480
tacaccttta ctcgctacac catgcattgg gtccggcagg ctcccggaca gggcctggaa 540
tggatgggat acatcaaccc ttctcggggc tacacaaact acaatcagaa attcaaggat 600
cgagtgacca tgacaaccga cacttcaatc tctaccgctt acatggaact gtctcggctg 660
aggagtgacg ataccgctgt ctactactgt gctcggtact acgacgacca ttactgcctg 720
gattactggg ggcagggcac actggtgact gtgtctagcg gcggctgc              768

<210> 43
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 43
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile
                85                  90                  95      
Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu
145                 150                 155                 160 
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val
                165                 170                 175     
Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
            180                 185                 190         
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe
        195                 200                 205             
Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
    210                 215                 220                 
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn
225                 230                 235                 240 
Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250                 255     


<210> 44
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 44
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagag tggagctgag gtgaaaaaac ccggcgcttc cgtcaaagtc 120
tcctgtaagg ctagcggata cacctttact cgctacacca tgcattgggt ccggcaggct 180
cccggacagg gcctggaatg gatgggatac atcaaccctt ctcggggcta cacaaactac 240
aatcagaaat tcaaggatcg agtgaccatg acaaccgaca cttcaatctc taccgcttac 300
atggaactgt ctcggctgag gagtgacgat accgctgtct actactgtgc tcggtactac 360
gacgaccatt actgcctgga ttactggggg cagggcacac tggtgactgt gtctagcggc 420
ggagggagtg gcggaggcgg cgaaatcgtg ctgactcagt cccctgctac actgtctctg 480
tcacctggcg aacgagcaac actgtcctgt tctgcctctt cttctgtctc atacatgaac 540
tggtaccagc agaaacctgg acaggctcct agactgctga tctacgacac ctctaaactg 600
gcatctggcg tgcccgctca ttttcgtggc tctggatctg gaaccgactt taccctgacc 660
atctcttccc tggaacctga ggattttgcc gtgtactact gccagcagtg gtctagtaac 720
cctttcactt ttggccaggg cactaaagtg gagatcaagg gcggctgc              768

<210> 45
<211> 389
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 45
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Ser Ser Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
145                 150                 155                 160 
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
                165                 170                 175     
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
            180                 185                 190         
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
        195                 200                 205             
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
    210                 215                 220                 
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
225                 230                 235                 240 
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
                245                 250                 255     
Val Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            260                 265                 270         
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro
        275                 280                 285             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
    290                 295                 300                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
305                 310                 315                 320 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                325                 330                 335     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            340                 345                 350         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        355                 360                 365             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    370                 375                 380                 
Leu Ser Pro Gly Lys
385                 


<210> 46
<211> 1170
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 46
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt ggctccacat ccggcggagg ctctggcggt 420
ggatctggcg gaggcggctc atccgacatc cagctgactc agcccaactc tgtgtctacg 480
tctctaggaa gcacagtcaa gctgtcttgc acactcagct ctggtaacat agaaaacaac 540
tatgtgcact ggtaccagct atatgaggga agatctccca ccactatgat ttatgatgat 600
gataagagac cggatggtgt ccctgacagg ttctctggct ccattgacag gtcttccaac 660
tcagccttcc tgacaatcca taatgtggca attgaagatg aagctatcta cttctgtcat 720
tcttatgtta gtagttttaa tgttttcggc ggtggaacaa agctcactgt ccttgagcct 780
aagtcctgcg acaagaccca cacctgtccc ccttgcggcg gaggaagcag cggaggcgga 840
tccggtggcc agcctcggga gcctcaggtg tacaccctgc ctccctcccg ggacgagctg 900
accaagaacc aggtgtccct gacctgtctg gtcaagggct tctacccttc cgatatcgcc 960
gtggagtggg agtccaacgg ccagcctgag aacaactaca agaccacccc tcctgtgctg 1020
gactccgacg gctccttctt cctgtactcc aagctcacag tggataagtc ccggtggcag 1080
cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctatacccag 1140
aagtccctgt ccctgtctcc tggcaagtga                                  1170

<210> 47
<211> 389
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 47
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Ser Ser Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
145                 150                 155                 160 
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
                165                 170                 175     
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
            180                 185                 190         
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
        195                 200                 205             
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
    210                 215                 220                 
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
225                 230                 235                 240 
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
                245                 250                 255     
Val Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            260                 265                 270         
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro
        275                 280                 285             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
    290                 295                 300                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
305                 310                 315                 320 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                325                 330                 335     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            340                 345                 350         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        355                 360                 365             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    370                 375                 380                 
Leu Ser Pro Gly Lys
385                 


<210> 48
<211> 1170
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 48
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt ggctccacat ccggcggagg ctctggcggt 420
ggatctggcg gaggcggctc atccgacatc cagctgactc agcccaactc tgtgtctacg 480
tctctaggaa gcacagtcaa gctgtcttgc acactcagct ctggtaacat agaaaacaac 540
tatgtgcact ggtaccagct atatgaggga agatctccca ccactatgat ttatgatgat 600
gataagagac cggatggtgt ccctgacagg ttctctggct ccattgacag gtcttccaac 660
tcagccttcc tgacaatcca taatgtggca attgaagatg aagctatcta cttctgtcat 720
tcttatgtta gtagttttaa tgttttcggc ggtggaacaa agctcactgt ccttgagcct 780
aagtcctgcg acaagaccca cacctgtccc ccttgcggcg gaggaagcag cggaggcgga 840
tccggtggcc agcctcggga gcctcaggtg tacaccctgc ctccctcccg ggacgagctg 900
accaagaacc aggtgtccct gacctgtctg gtcaagggct tctacccttc cgatatcgcc 960
gtggagtggg agtccaacgg ccagcctgag aacaactaca agaccacccc tcctgtgctg 1020
gactccgacg gctccttctt cctgtactcc aagctcacag tggataagtc ccggtggcag 1080
cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctatacccag 1140
aagtccctgt ccctgtctcc tggcaagtga                                  1170

<210> 49
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 49
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Ser Gly Gly Gly Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser
    130                 135                 140                 
Val Ser Thr Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser
145                 150                 155                 160 
Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu
                165                 170                 175     
Gly Arg Ser Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp
            180                 185                 190         
Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser
        195                 200                 205             
Ala Phe Leu Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr
    210                 215                 220                 
Phe Cys His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr
225                 230                 235                 240 
Lys Leu Thr Val Leu Gly Gly Cys
                245             


<210> 50
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 50
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt agtggtggag gaggcgacat ccagctgact 420
cagcccaact ctgtgtctac gtctctagga agcacagtca agctgtcttg cacactcagc 480
tctggtaaca tagaaaacaa ctatgtgcac tggtaccagc tatatgaggg aagatctccc 540
accactatga tttatgatga tgataagaga ccggatggtg tccctgacag gttctctggc 600
tccattgaca ggtcttccaa ctcagccttc ctgacaatcc ataatgtggc aattgaagat 660
gaagctatct acttctgtca ttcttatgtt agtagtttta atgttttcgg cggtggaaca 720
aagctcactg tccttggcgg ctgc                                        744

<210> 51
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 51
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Ser Gly Gly Gly Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser
    130                 135                 140                 
Val Ser Thr Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser
145                 150                 155                 160 
Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu
                165                 170                 175     
Gly Arg Ser Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp
            180                 185                 190         
Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser
        195                 200                 205             
Ala Phe Leu Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr
    210                 215                 220                 
Phe Cys His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr
225                 230                 235                 240 
Lys Leu Thr Val Leu Gly Gly Cys
                245             


<210> 52
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 52
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt agtggtggag gaggcgacat ccagctgact 420
cagcccaact ctgtgtctac gtctctagga agcacagtca agctgtcttg cacactcagc 480
tctggtaaca tagaaaacaa ctatgtgcac tggtaccagc tatatgaggg aagatctccc 540
accactatga tttatgatga tgataagaga ccggatggtg tccctgacag gttctctggc 600
tccattgaca ggtcttccaa ctcagccttc ctgacaatcc ataatgtggc aattgaagat 660
gaagctatct acttctgtca ttcttatgtt agtagtttta atgttttcgg cggtggaaca 720
aagctcactg tccttggcgg ctgc                                        744

<210> 53
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 53
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Leu Thr Gln
    130                 135                 140                 
Pro Asn Ser Val Ser Thr Ser Leu Gly Ser Thr Val Lys Leu Ser Cys
145                 150                 155                 160 
Thr Leu Ser Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln
                165                 170                 175     
Leu Tyr Glu Gly Arg Ser Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys
            180                 185                 190         
Arg Pro Asp Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser
        195                 200                 205             
Ser Asn Ser Ala Phe Leu Thr Ile His Asn Val Ala Ile Glu Asp Glu
    210                 215                 220                 
Ala Ile Tyr Phe Cys His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly
225                 230                 235                 240 
Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Cys
                245                 250     


<210> 54
<211> 753
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 54
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt ggcggaggga gtggcggagg cggcgacatc 420
cagctgactc agcccaactc tgtgtctacg tctctaggaa gcacagtcaa gctgtcttgc 480
acactcagct ctggtaacat agaaaacaac tatgtgcact ggtaccagct atatgaggga 540
agatctccca ccactatgat ttatgatgat gataagagac cggatggtgt ccctgacagg 600
ttctctggct ccattgacag gtcttccaac tcagccttcc tgacaatcca taatgtggca 660
attgaagatg aagctatcta cttctgtcat tcttatgtta gtagttttaa tgttttcggc 720
ggtggaacaa agctcactgt ccttggcggc tgc                              753

<210> 55
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 55
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Leu Thr Gln
    130                 135                 140                 
Pro Asn Ser Val Ser Thr Ser Leu Gly Ser Thr Val Lys Leu Ser Cys
145                 150                 155                 160 
Thr Leu Ser Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln
                165                 170                 175     
Leu Tyr Glu Gly Arg Ser Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys
            180                 185                 190         
Arg Pro Asp Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser
        195                 200                 205             
Ser Asn Ser Ala Phe Leu Thr Ile His Asn Val Ala Ile Glu Asp Glu
    210                 215                 220                 
Ala Ile Tyr Phe Cys His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly
225                 230                 235                 240 
Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Cys
                245                 250     


<210> 56
<211> 753
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 56
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt ggcggaggga gtggcggagg cggcgacatc 420
cagctgactc agcccaactc tgtgtctacg tctctaggaa gcacagtcaa gctgtcttgc 480
acactcagct ctggtaacat agaaaacaac tatgtgcact ggtaccagct atatgaggga 540
agatctccca ccactatgat ttatgatgat gataagagac cggatggtgt ccctgacagg 600
ttctctggct ccattgacag gtcttccaac tcagccttcc tgacaatcca taatgtggca 660
attgaagatg aagctatcta cttctgtcat tcttatgtta gtagttttaa tgttttcggc 720
ggtggaacaa agctcactgt ccttggcggc tgc                              753

<210> 57
<211> 395
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 57
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser
            100                 105                 110         
Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
        115                 120                 125             
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro
145                 150                 155                 160 
Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser
                165                 170                 175     
Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
            180                 185                 190         
Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Val Asp
        195                 200                 205             
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
    210                 215                 220                 
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
225                 230                 235                 240 
Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp Gly Arg
                245                 250                 255     
Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr
            260                 265                 270         
His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
        275                 280                 285             
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
    290                 295                 300                 
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
305                 310                 315                 320 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                325                 330                 335     
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
            340                 345                 350         
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
        355                 360                 365             
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
    370                 375                 380                 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 395 


<210> 58
<211> 1188
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 58
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc 120
ctgagctgcc gcgcgagcca gagcgtgagc agctatctgg cgtggtatca gcagaaaccg 180
ggccaggcgc cgcgcctgct gatttatgat gcgagcaacc gcgcgaccgg cattccggcg 240
cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctggaaccg 300
gaagattttg cggtgtatta ttgccagcag cgcagcaact ggccgccgct gacctttggc 360
ggcggcacca aagtggaaat taaaggctcc acatccggcg gaggctctgg cggtggatct 420
ggcggaggcg gctcatccca ggtgcagctg gtggaaagcg gcggcggcgt ggtgcagccg 480
ggccgcagcc tgcgcctgag ctgcgcggcg agcggcttta aatttagcgg ctatggcatg 540
cattgggtgc gccaggcgcc gggcaaaggc ctggaatggg tggcggtgat ttggtatgat 600
ggcagcaaaa aatattatgt ggatagcgtg aaaggccgct ttaccattag ccgcgataac 660
agcaaaaaca ccctgtatct gcagatgaac agcctgcgcg cggaagatac cgcggtgtat 720
tattgcgcgc gccagatggg ctattggcat tttgatctgt ggggccgcgg caccctggtg 780
accgtgagca gcgagcctaa gtcctgcgac aagacccaca cctgtccccc ttgcggcgga 840
ggaagcagcg gaggcggatc cggtggccag cctcgggagc ctcaggtgta caccctgcct 900
ccctcccggg acgagctgac caagaaccag gtgtccctga cctgtctggt caagggcttc 960
tacccttccg atatcgccgt ggagtgggag tccaacggcc agcctgagaa caactacaag 1020
accacccctc ctgtgctgga ctccgacggc tccttcttcc tgtactccaa gctcacagtg 1080
gataagtccc ggtggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg 1140
cacaaccact atacccagaa gtccctgtcc ctgtctcctg gcaagtga              1188

<210> 59
<211> 395
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 59
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys
        35                  40                  45              
Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr
65                  70                  75                  80  
Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp
        115                 120                 125             
Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly
    130                 135                 140                 
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val Leu
145                 150                 155                 160 
Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr
                165                 170                 175     
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr
            180                 185                 190         
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser
        195                 200                 205             
Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala
225                 230                 235                 240 
Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Leu Thr Phe Gly
                245                 250                 255     
Gly Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr
            260                 265                 270         
His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
        275                 280                 285             
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
    290                 295                 300                 
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
305                 310                 315                 320 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                325                 330                 335     
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
            340                 345                 350         
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
        355                 360                 365             
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
    370                 375                 380                 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 395 


<210> 60
<211> 1188
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 60
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg 120
agctgcgcgg cgagcggctt taaatttagc ggctatggca tgcattgggt gcgccaggcg 180
ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa aaaatattat 240
gtggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat 300
ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccagatg 360
ggctattggc attttgatct gtggggccgc ggcaccctgg tgaccgtgag cagcggctcc 420
acatccggcg gaggctctgg cggtggatct ggcggaggcg gctcatccga aattgtgctg 480
acccagagcc cggcgaccct gagcctgagc ccgggcgaac gcgcgaccct gagctgccgc 540
gcgagccaga gcgtgagcag ctatctggcg tggtatcagc agaaaccggg ccaggcgccg 600
cgcctgctga tttatgatgc gagcaaccgc gcgaccggca ttccggcgcg ctttagcggc 660
agcggcagcg gcaccgattt taccctgacc attagcagcc tggaaccgga agattttgcg 720
gtgtattatt gccagcagcg cagcaactgg ccgccgctga cctttggcgg cggcaccaaa 780
gtggaaatta aagagcctaa gtcctgcgac aagacccaca cctgtccccc ttgcggcgga 840
ggaagcagcg gaggcggatc cggtggccag cctcgggagc ctcaggtgta caccctgcct 900
ccctcccggg acgagctgac caagaaccag gtgtccctga cctgtctggt caagggcttc 960
tacccttccg atatcgccgt ggagtgggag tccaacggcc agcctgagaa caactacaag 1020
accacccctc ctgtgctgga ctccgacggc tccttcttcc tgtactccaa gctcacagtg 1080
gataagtccc ggtggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg 1140
cacaaccact atacccagaa gtccctgtcc ctgtctcctg gcaagtga              1188

<210> 61
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 61
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser
            100                 105                 110         
Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
        115                 120                 125             
Ser Gly Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val
    130                 135                 140                 
Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
145                 150                 155                 160 
Lys Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys
                165                 170                 175     
Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr
            180                 185                 190         
Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
        195                 200                 205             
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
    210                 215                 220                 
Ala Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu
225                 230                 235                 240 
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250                 


<210> 62
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 62
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc 120
ctgagctgcc gcgcgagcca gagcgtgagc agctatctgg cgtggtatca gcagaaaccg 180
ggccaggcgc cgcgcctgct gatttatgat gcgagcaacc gcgcgaccgg cattccggcg 240
cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctggaaccg 300
gaagattttg cggtgtatta ttgccagcag cgcagcaact ggccgccgct gacctttggc 360
ggcggcacca aagtggaaat taaaagtggt ggaggaggcc aggtgcagct ggtggaaagc 420
ggcggcggcg tggtgcagcc gggccgcagc ctgcgcctga gctgcgcggc gagcggcttt 480
aaatttagcg gctatggcat gcattgggtg cgccaggcgc cgggcaaagg cctggaatgg 540
gtggcggtga tttggtatga tggcagcaaa aaatattatg tggatagcgt gaaaggccgc 600
tttaccatta gccgcgataa cagcaaaaac accctgtatc tgcagatgaa cagcctgcgc 660
gcggaagata ccgcggtgta ttattgcgcg cgccagatgg gctattggca ttttgatctg 720
tggggccgcg gcaccctggt gaccgtgagc agcggcggct gc                    762

<210> 63
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 63
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys
        35                  40                  45              
Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr
65                  70                  75                  80  
Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp
        115                 120                 125             
Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu
    130                 135                 140                 
Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu
145                 150                 155                 160 
Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu
                165                 170                 175     
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
            180                 185                 190         
Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
    210                 215                 220                 
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Leu
225                 230                 235                 240 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250                 


<210> 64
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 64
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg 120
agctgcgcgg cgagcggctt taaatttagc ggctatggca tgcattgggt gcgccaggcg 180
ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa aaaatattat 240
gtggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat 300
ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccagatg 360
ggctattggc attttgatct gtggggccgc ggcaccctgg tgaccgtgag cagcagtggt 420
ggaggaggcg aaattgtgct gacccagagc ccggcgaccc tgagcctgag cccgggcgaa 480
cgcgcgaccc tgagctgccg cgcgagccag agcgtgagca gctatctggc gtggtatcag 540
cagaaaccgg gccaggcgcc gcgcctgctg atttatgatg cgagcaaccg cgcgaccggc 600
attccggcgc gctttagcgg cagcggcagc ggcaccgatt ttaccctgac cattagcagc 660
ctggaaccgg aagattttgc ggtgtattat tgccagcagc gcagcaactg gccgccgctg 720
acctttggcg gcggcaccaa agtggaaatt aaaggcggct gc                    762

<210> 65
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 65
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser
            100                 105                 110         
Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly
    130                 135                 140                 
Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala
145                 150                 155                 160 
Ser Gly Phe Lys Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala
                165                 170                 175     
Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser
            180                 185                 190         
Lys Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
        195                 200                 205             
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
    210                 215                 220                 
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His
225                 230                 235                 240 
Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly
                245                 250                 255     
Cys
    


<210> 66
<211> 771
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 66
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc 120
ctgagctgcc gcgcgagcca gagcgtgagc agctatctgg cgtggtatca gcagaaaccg 180
ggccaggcgc cgcgcctgct gatttatgat gcgagcaacc gcgcgaccgg cattccggcg 240
cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctggaaccg 300
gaagattttg cggtgtatta ttgccagcag cgcagcaact ggccgccgct gacctttggc 360
ggcggcacca aagtggaaat taaaggcgga gggagtggcg gaggcggcca ggtgcagctg 420
gtggaaagcg gcggcggcgt ggtgcagccg ggccgcagcc tgcgcctgag ctgcgcggcg 480
agcggcttta aatttagcgg ctatggcatg cattgggtgc gccaggcgcc gggcaaaggc 540
ctggaatggg tggcggtgat ttggtatgat ggcagcaaaa aatattatgt ggatagcgtg 600
aaaggccgct ttaccattag ccgcgataac agcaaaaaca ccctgtatct gcagatgaac 660
agcctgcgcg cggaagatac cgcggtgtat tattgcgcgc gccagatggg ctattggcat 720
tttgatctgt ggggccgcgg caccctggtg accgtgagca gcggcggctg c          771

<210> 67
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 67
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys
        35                  40                  45              
Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr
65                  70                  75                  80  
Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp
        115                 120                 125             
Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser
145                 150                 155                 160 
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
                165                 170                 175     
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
            180                 185                 190         
Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe
        195                 200                 205             
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
    210                 215                 220                 
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp
225                 230                 235                 240 
Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly
                245                 250                 255     
Cys
    


<210> 68
<211> 771
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 68
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg 120
agctgcgcgg cgagcggctt taaatttagc ggctatggca tgcattgggt gcgccaggcg 180
ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa aaaatattat 240
gtggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat 300
ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccagatg 360
ggctattggc attttgatct gtggggccgc ggcaccctgg tgaccgtgag cagcggcgga 420
gggagtggcg gaggcggcga aattgtgctg acccagagcc cggcgaccct gagcctgagc 480
ccgggcgaac gcgcgaccct gagctgccgc gcgagccaga gcgtgagcag ctatctggcg 540
tggtatcagc agaaaccggg ccaggcgccg cgcctgctga tttatgatgc gagcaaccgc 600
gcgaccggca ttccggcgcg ctttagcggc agcggcagcg gcaccgattt taccctgacc 660
attagcagcc tggaaccgga agattttgcg gtgtattatt gccagcagcg cagcaactgg 720
ccgccgctga cctttggcgg cggcaccaaa gtggaaatta aaggcggctg c          771

<210> 69
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = C or S

<400> 69
Tyr Tyr Asp Asp His Tyr Xaa Leu Asp Tyr
 1               5                  10  


<210> 70
<211> 106
<212> PRT
<213> Mus musculus

<400> 70
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn
            100                 105     


<210> 71
<211> 318
<212> DNA
<213> Homo sapiens

<400> 71
gacatccaga tgacccagtc tccttcttct ctgtctgctt ctgtcggaga cagagtcaca 60
atcacatgtt ctgcttctag ctctgtctct tacatgaact ggtaccagca gacacctgga 120
aaggctccta agcggtggat ctacgacaca tctaagctcg cttctggagt cccttctaga 180
ttctctggtt ctggctctgg aacagactac acattcacaa tctcttctct ccaacctgag 240
gacatcgcta catactactg ccaacagtgg tctagcaatc ctttcacatt cggacaggga 300
acaaagctgc agatcaca                                               318

<210> 72
<211> 106
<212> PRT
<213> Homo sapiens

<400> 72
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
65                  70                  75                  80  
Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr
            100                 105     


<210> 73
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 73
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gtgccagctc aagtgtaagt tacatgaact ggtaccaaca gaaacctggc 120
caggctccca ggctcctcat ctatgacaca tccaaactgg cttctggagt ccctgctcac 180
ttcaggggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa 240
gattttgcag tttattactg tcagcagtgg agtagtaacc cattcacgtt cggccaaggg 300
accaaggtgg aaatcaaa                                               318

<210> 74
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 74
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105     


<210> 75
<211> 357
<212> DNA
<213> Mus musculus

<400> 75
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg 60
tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg 120
cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac 180
aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac 240
atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat 300
gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctca    357

<210> 76
<211> 119
<212> PRT
<213> Mus musculus

<400> 76
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 77
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 77
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg 60
tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg 120
cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac 180
aaatgcaact gagcagcctg acatctgagg actctgcagt ctattactgt gcaagatatt 240
attcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac 300
gatgatcatt actcacttga ctactggggc caaggcacca ctctcacagt ctcctca    357

<210> 78
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 78
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 79
<211> 357
<212> DNA
<213> Homo sapiens

<400> 79
caggttcagc tggtgcagtc tggaggagga gtcgtccagc ctggaaggtc cctgagactg 60
tcttgtaagg cttctggata caccttcact agatacacaa tgcactgggt cagacaggct 120
cctggaaagg gactcgagtg gattggatac attaatccta gcagaggtta tactaactac 180
aatcagactg cagatggact cactcagacc tgaggatacc ggagtctatt tttgtgctag 240
atattacagg tgaaggacag attcacaatt tctagagaca attctaagaa tacagccttc 300
gatgaccact actgtctgga ctactggggc caaggtaccc cggtcaccgt gagctca    357

<210> 80
<211> 119
<212> PRT
<213> Homo sapiens

<400> 80
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
    50                  55                  60                  
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
65                  70                  75                  80  
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Pro Val Thr Val Ser Ser
        115                 


<210> 81
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 81
caggttcagc tggtgcagtc tggaggagga gtcgtccagc ctggaaggtc cctgagactg 60
tcttgtaagg cttctggata caccttcact agatacacaa tgcactgggt cagacaggct 120
cctggaaagg gactcgagtg gattggatac attaatccta gcagaggtta tactaactac 180
aatcagaagg tgaaggacag attcacaatt tctagagaca attctaagaa tacagccttc 240
ctgcagatgg actcactcag acctgaggat accggagtct atttttgtgc tagatattac 300
gatgaccact actcactgga ctactggggc caaggtaccc cggtcaccgt gagctca    357

<210> 82
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 82
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
    50                  55                  60                  
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
65                  70                  75                  80  
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Pro Val Thr Val Ser Ser
        115                 


<210> 83
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 83
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc aggtacacga tgcactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatac attaatccta gccgtggtta tactaattac 180
aatcagaagt tcaaggacag ggtcaccatg accacagaca cgtccatcag cacagcctac 240
atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagatattat 300
gatgatcatt actgccttga ctactggggc cagggcaccc tggtcaccgt ctcctca    357

<210> 84
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 84
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 85
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 85
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc aggtacacga tgcactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatac attaatccta gccgtggtta tactaattac 180
aatcagaagt tcaaggacag ggtcaccatg accacagaca cgtccatcag cacagcctac 240
atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagatattat 300
gatgatcatt actcacttga ctactggggc cagggcaccc tggtcaccgt ctcctca    357

<210> 86
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 86
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 87
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 87
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60


<210> 88
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 88
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly
            20  


<210> 89
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 89
agtggtggag gaggc                                                  15

<210> 90
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 90
Ser Gly Gly Gly Gly
 1               5  


<210> 91
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 91
ggcggaggga gtggcggagg cggc                                        24

<210> 92
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 92
Gly Gly Gly Ser Gly Gly Gly Gly
 1               5              


<210> 93
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 93
ggcggctgc                                                         9

<210> 94
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 94
Gly Gly Cys
 1          


<210> 95
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 95
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60


<210> 96
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 96
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly
            20  


<210> 97
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 97
ggctccacat ccggcggagg ctctggcggt ggatctggcg gaggcggctc atcc       54

<210> 98
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 98
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser Ser
        


<210> 99
<211> 393
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 99
gagcctaagt cctgcgacaa gacccacacc tgtccccctt gcggcggagg aagcagcgga 60
ggcggatccg gtggccagcc tcgggagcct caggtgtaca ccctgcctcc ctcccgggac 120
gagctgacca agaaccaggt gtccctgacc tgtctggtca agggcttcta cccttccgat 180
atcgccgtgg agtgggagtc caacggccag cctgagaaca actacaagac cacccctcct 240
gtgctggact ccgacggctc cttcttcctg tactccaagc tcacagtgga taagtcccgg 300
tggcagcagg gcaacgtgtt ctcctgctcc gtgatgcacg aggccctgca caaccactat 360
acccagaagt ccctgtccct gtctcctggc aag                              393

<210> 100
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 100
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
 1               5                  10                  15      
Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val
            20                  25                  30          
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        35                  40                  45              
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    50                  55                  60                  
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
65                  70                  75                  80  
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                85                  90                  95      
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            100                 105                 110         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        115                 120                 125             
Pro Gly Lys
    130     


<210> 101
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 101
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 102
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 102
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Gly
 1               5                  10                  15      
Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25  


<210> 103
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 103
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro
            


<210> 104
<211> 70
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 104
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys
 1               5                  10                  15      
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
            20                  25                  30          
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu
        35                  40                  45              
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro
    50                  55                  60                  
Glu Leu Leu Gly Gly Pro
65                  70  


<210> 105
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 105
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys
 1               5                  10                  15      
Pro Ala Pro Glu Leu Leu Gly Gly Pro
            20                  25  


<210> 106
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 106
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 107
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 107
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro
            20  


<210> 108
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 108
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro
            20  


<210> 109
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 109
Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser
 1               5                  10                  15      
Val Gly Val Trp Gly Gln
            20          


<210> 110
<211> 185
<212> PRT
<213> Homo sapiens

<400> 110
Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val
 1               5                  10                  15      
Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly
            20                  25                  30          
Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu
        35                  40                  45              
Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu
    50                  55                  60                  
Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly
65                  70                  75                  80  
Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val
                85                  90                  95      
Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val
            100                 105                 110         
Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr
        115                 120                 125             
Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala
    130                 135                 140                 
Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro
145                 150                 155                 160 
Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu
                165                 170                 175     
Tyr Ser Gly Leu Asn Gln Arg Arg Ile
            180                 185 


<210> 111
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 111
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser
    


<210> 112
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 112
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Ser Glu Gly Ser Thr
 1               5                  10                  15      
Lys Gly
        


<210> 113
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 113
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 114
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 114
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc 60
atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc 120
acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac 180
ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa 240
gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg 300
acaaagttgg aaataaac                                               318

<210> 115
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 115
Gly Gly Cys Gly Gly Cys
 1               5      


<210> 116
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 116
Gly Gly Cys Gly Cys
 1               5  


<210> 117
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 117
Gly Gly Cys Cys
 1              


<210> 118
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 118
tctagagccg ccacc                                                  15

<210> 119
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 119
aagctt                                                            6

<210> 120
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 120
tctagagccg ccacc                                                  15

<210> 121
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 121
aagctt                                                            6

<210> 122
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 122
tctagagccg ccacc                                                  15

<210> 123
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 123
aagctt                                                            6

<210> 124
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 124
tctagagccg ccacc                                                  15

<210> 125
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 125
aagctt                                                            6
