                         SEQUENCE LISTING

<110>  Doudna, Jennifer A.
       Jinek, Martin
       Sternberg, Samuel H.
 
<120>  ENDORIBONUCLEASES AND METHODS OF USE THEREOF

<130>  BERK-190WO

<150>  US 61/660,414
<151>  2012-06-15

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  1
guugcaaggg auugagcccc guaaggggau ugcgac                                 36


<210>  2
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  2
guugcaaacc ucguuagccu cguagaggau ugaaac                                 36


<210>  3
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  3
ggaucgauac ccaccccgaa gaaaagggga cgagaac                                37


<210>  4
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  4
gucgucagac ccaaaacccc gagaggggac ggaaac                                 36


<210>  5
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  5
gauauaaacc uaauuaccuc gagaggggac ggaaac                                 36


<210>  6
<211>  29
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  6
ccccagucac cucgggaggg gacggaaac                                         29


<210>  7
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  7
guuccaauua aucuuaaacc cuauuaggga uugaaac                                37


<210>  8
<211>  32
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  8
gucgcccccc acgcgggggc guggauugaa ac                                     32


<210>  9
<211>  32
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  9
ccagccgccu ucgggcggcu guguguugaa ac                                     32


<210>  10
<211>  32
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  10
gucgcacucu acaugagugc guggauugaa au                                     32


<210>  11
<211>  33
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  11
ugucgcaccu uauauaggug cguggauuga aau                                    33


<210>  12
<211>  32
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  12
gucgcgcccc gcauggggcg cguggauuga aa                                     32


<210>  13
<211>  227
<212>  PRT
<213>  Desulfovibrio vulgaris str. Hildenborough

<400>  13

Met Thr His Gly Ala Val Lys Thr Tyr Gly Ile Arg Leu Arg Val Trp 
1               5                   10                  15      


Gly Asp Tyr Ala Cys Phe Thr Arg Pro Glu Met Lys Val Glu Arg Val 
            20                  25                  30          


Ser Tyr Asp Val Met Pro Pro Ser Ala Ala Arg Gly Ile Leu Glu Ala 
        35                  40                  45              


Ile His Trp Lys Pro Ala Ile Arg Trp Ile Val Asp Arg Ile His Val 
    50                  55                  60                  


Leu Arg Pro Ile Val Phe Asp Asn Val Arg Arg Asn Glu Val Ser Ser 
65                  70                  75                  80  


Lys Ile Pro Lys Pro Asn Pro Ala Thr Ala Met Arg Asp Arg Lys Pro 
                85                  90                  95      


Leu Tyr Phe Leu Val Asp Asp Gly Ser Asn Arg Gln Gln Arg Ala Ala 
            100                 105                 110         


Thr Leu Leu Arg Asn Val Asp Tyr Val Ile Glu Ala His Phe Glu Leu 
        115                 120                 125             


Thr Asp Lys Ala Gly Ala Glu Asp Asn Ala Gly Lys His Leu Asp Ile 
    130                 135                 140                 


Phe Arg Arg Arg Ala Arg Ala Gly Gln Ser Phe Gln Gln Pro Cys Leu 
145                 150                 155                 160 


Gly Cys Arg Glu Phe Pro Ala Ser Phe Glu Leu Leu Glu Gly Asp Val 
                165                 170                 175     


Pro Leu Ser Cys Tyr Ala Gly Glu Lys Arg Asp Leu Gly Tyr Met Leu 
            180                 185                 190         


Leu Asp Ile Asp Phe Glu Arg Asp Met Thr Pro Leu Phe Phe Lys Ala 
        195                 200                 205             


Val Met Glu Asp Gly Val Ile Thr Pro Pro Ser Arg Thr Ser Pro Glu 
    210                 215                 220                 


Val Arg Ala 
225         


<210>  14
<211>  15
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  14
gccccguuag gggau                                                        15


<210>  15
<211>  30
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  15
guugcaaggg auugagcccc guuaggggau                                        30


<210>  16
<211>  267
<212>  PRT
<213>  Meiothermus silvanus DSM 9946

<400>  16

Met Met Leu Ala Ala Leu Val Leu Pro Leu Glu Gly Gln Ala Arg Pro 
1               5                   10                  15      


Asp Pro Asp Gly Trp Arg Gly Leu Val Tyr Gly Leu Leu Lys Glu Ile 
            20                  25                  30          


Asp Pro Glu Leu His Thr Ala Gln His Asn Pro Phe Ser Leu Gly Leu 
        35                  40                  45              


Gly Gly Ala Glu Gly Gln Trp Trp Val Arg Ile Ala Leu Leu Glu Glu 
    50                  55                  60                  


Gly Leu Tyr Ala Arg Leu Ser Pro His Leu Phe Gly Leu Val Gly Gln 
65                  70                  75                  80  


Ser Val Lys Leu Lys Glu Pro Phe Arg Val Arg Ala Val Leu Gln Glu 
                85                  90                  95      


Glu His Pro Trp Ala Ser Leu Ser Thr Tyr Pro Arg Leu Phe Gln Gly 
            100                 105                 110         


Gln Ala Ser Pro Ser Leu Gly Leu Gln Phe Ala Ser Pro Thr Phe Phe 
        115                 120                 125             


Arg Arg Lys Gly Asn Ser Tyr Pro Leu Pro Glu Pro Lys Leu Val Phe 
    130                 135                 140                 


Asp Ser Leu Thr Gln Arg Trp Asn Ala Phe Ala Pro Val Lys Val Pro 
145                 150                 155                 160 


Pro Glu Met Ala Glu Thr Trp Glu Arg Val Thr Ile Thr Arg Leu Gln 
                165                 170                 175     


Gly His Thr Gln Ala Ile Arg Pro Asn Pro Asp Glu Arg Gly Val Gly 
            180                 185                 190         


Phe Val Gly Arg Val Val Tyr His Leu Pro Ala Ala Lys Pro Thr Glu 
        195                 200                 205             


Ala Gln Trp Met Gln Ala Leu Gly Arg Phe Ala Phe Tyr Ala Gly Val 
    210                 215                 220                 


Gly Ala Lys Thr Ser Leu Gly Phe Gly Arg Val Arg Gly Phe Asp Pro 
225                 230                 235                 240 


Ile Leu Lys Glu Glu Ser Ala Asn Gly Arg Leu Asp Ala Glu Asp Ser 
                245                 250                 255     


Ser Ser Leu Ala Thr Pro Gln Asp Pro Gly Ala 
            260                 265         


<210>  17
<211>  267
<212>  PRT
<213>  Meiothermus silvanus DSM 9946

<400>  17

Met Met Leu Ala Ala Leu Val Leu Pro Leu Glu Gly Gln Ala Arg Pro 
1               5                   10                  15      


Asp Pro Asp Gly Trp Arg Gly Leu Val Tyr Gly Leu Leu Lys Glu Ile 
            20                  25                  30          


Asp Pro Glu Leu His Thr Ala Gln His Asn Pro Phe Ser Leu Gly Leu 
        35                  40                  45              


Gly Gly Ala Glu Gly Gln Trp Trp Val Arg Ile Ala Leu Leu Glu Glu 
    50                  55                  60                  


Gly Leu Tyr Ala Arg Leu Ser Pro His Leu Phe Gly Leu Val Gly Gln 
65                  70                  75                  80  


Ser Val Lys Leu Lys Glu Pro Phe Arg Val Arg Ala Val Leu Gln Glu 
                85                  90                  95      


Glu His Pro Trp Ala Ser Leu Ser Thr Tyr Pro Arg Leu Phe Gln Gly 
            100                 105                 110         


Gln Ala Ser Pro Ser Leu Gly Leu Gln Phe Ala Ser Pro Thr Phe Phe 
        115                 120                 125             


Arg Arg Lys Gly Asn Ser Tyr Pro Leu Pro Glu Pro Lys Leu Val Phe 
    130                 135                 140                 


Asp Ser Leu Thr Gln Arg Trp Asn Ala Phe Ala Pro Val Lys Val Pro 
145                 150                 155                 160 


Pro Glu Met Ala Glu Thr Trp Glu Arg Val Thr Ile Thr Arg Leu Gln 
                165                 170                 175     


Gly His Thr Gln Ala Ile Arg Pro Asn Pro Asp Glu Arg Gly Val Gly 
            180                 185                 190         


Phe Val Gly Arg Val Val Tyr His Leu Pro Ala Ala Lys Pro Thr Glu 
        195                 200                 205             


Ala Gln Trp Met Gln Ala Leu Gly Arg Phe Ala Phe Tyr Ala Gly Val 
    210                 215                 220                 


Gly Ala Lys Thr Ser Leu Gly Phe Gly Arg Val Arg Gly Phe Asp Pro 
225                 230                 235                 240 


Ile Leu Lys Glu Glu Ser Ala Asn Gly Arg Leu Asp Ala Glu Asp Ser 
                245                 250                 255     


Ser Ser Leu Ala Thr Pro Gln Asp Pro Gly Ala 
            260                 265         


<210>  18
<211>  262
<212>  PRT
<213>  Meiothermus ruber DSM 1279

<400>  18

Met Ile Leu Ala Ala Leu Ile Leu Pro Leu Glu Gly Pro Thr Arg Pro 
1               5                   10                  15      


Asp Pro Asp Gly Trp Arg Gly Leu Val Tyr Gly Leu Leu Lys Glu Ile 
            20                  25                  30          


Asp Pro Glu Leu His Ala Ala Gln His Asn Pro Phe Ser Leu Gly Leu 
        35                  40                  45              


Gly Gly Ala Leu Gly Gln Trp Trp Val Arg Ile Ala Phe Leu Glu Glu 
    50                  55                  60                  


Gly Leu Tyr Ala Arg Leu Ser Pro His Leu Phe Gly Leu Ala Gly Gln 
65                  70                  75                  80  


Thr Val Arg Leu Lys Glu Ala Phe Gln Val Arg Ala Val Leu Gln Glu 
                85                  90                  95      


Ala His Pro Trp Ala Gly Val Ser Thr Tyr Pro Lys Leu Phe Gln Gly 
            100                 105                 110         


Gln Ala Thr Ala Ser Leu Gly Leu Gln Phe Ala Ser Pro Thr Phe Phe 
        115                 120                 125             


Arg Arg Lys Gly His Ser Tyr Pro Leu Pro Glu Pro Arg Leu Val Phe 
    130                 135                 140                 


Glu Ser Leu Thr Gln Arg Trp Asn Ala Phe Ala Pro Val Lys Val Pro 
145                 150                 155                 160 


Gln Glu Val Gln Glu Ala Trp Glu Arg Leu Leu Val Gly Gln Phe Gln 
                165                 170                 175     


Gly Arg Thr His His Ile Ala Pro Asn Gln Asp Glu Arg Gly Val Gly 
            180                 185                 190         


Phe Val Gly Arg Val Val Tyr Tyr Leu Pro Lys Ala Ser Pro Thr Glu 
        195                 200                 205             


Ala Gln Trp Leu Gln Ala Leu Gly Arg Phe Ala Phe Tyr Ala Gly Val 
    210                 215                 220                 


Gly Ala Lys Thr Ser Leu Gly Phe Gly Arg Val Arg Met Phe Asp Pro 
225                 230                 235                 240 


Leu Gln Gln Glu Arg Arg Pro Asp Glu Ser Glu Gln Gly Ala Leu Thr 
                245                 250                 255     


Gly Thr Val Gly Gly Val 
            260         


<210>  19
<211>  239
<212>  PRT
<213>  Thermus thermophilus HB8

<400>  19

Met Val Leu Ala Ala Leu Val Leu Val Leu Glu Gly Glu Gly Leu Pro 
1               5                   10                  15      


Glu Pro Leu Gly Leu Arg Gly Phe Phe Tyr Gly Leu Leu Arg Glu Val 
            20                  25                  30          


Ala Pro Glu Val His Asp Gln Gly Glu Asn Pro Phe Ala Leu Gly Phe 
        35                  40                  45              


Gly Gly Arg Glu Gly Ala Ala Trp Ala Arg Val Ser Leu Leu Val Glu 
    50                  55                  60                  


Gly Leu Tyr Ala Arg Leu Ala Pro Arg Leu Tyr Ala Leu Glu Gly Glu 
65                  70                  75                  80  


Glu Val Arg Leu Gly Pro Pro Phe Arg Val Arg Ala Val Leu Gln Glu 
                85                  90                  95      


Gly His Pro Trp Ala Gly Val Ser Thr Tyr Pro Arg Leu Phe Gln Gly 
            100                 105                 110         


Pro Pro Ser Arg Asp Leu Ala Leu Arg Phe Ala Ser Pro Thr Phe Phe 
        115                 120                 125             


Arg Arg Lys Gly Val His Tyr Pro Val Pro Glu Pro Arg Leu Val Leu 
    130                 135                 140                 


Glu Ser Leu Leu Arg Arg Leu Glu Ala Phe Gly Pro Leu Lys Ala Pro 
145                 150                 155                 160 


Glu Gly Val Arg Glu Ala Leu Leu Glu Arg Thr Thr Val Arg Ser Leu 
                165                 170                 175     


Glu Gly Arg Thr Leu Pro Ala Arg Thr Glu Val Asp Thr Ala Gly Phe 
            180                 185                 190         


Val Gly Arg Val Val Tyr His Leu Pro Arg Ala Thr Glu Glu Glu Ala 
        195                 200                 205             


Leu Trp Leu Ser Ala Leu Gly Arg Phe Ala Phe Tyr Ser Gly Val Gly 
    210                 215                 220                 


Ala Lys Thr Ser Leu Gly Tyr Gly Arg Ala Arg Ala Glu Ser Ala 
225                 230                 235                 


<210>  20
<211>  239
<212>  PRT
<213>  Thermus thermophilus JL-18

<400>  20

Met Val Leu Ala Ala Leu Val Leu Val Leu Glu Gly Glu Gly Leu Pro 
1               5                   10                  15      


Glu Pro Leu Gly Leu Arg Gly Phe Phe Tyr Gly Leu Leu Arg Glu Val 
            20                  25                  30          


Ala Pro Glu Val His Asp Gln Gly Glu Asn Pro Phe Ala Leu Gly Phe 
        35                  40                  45              


Gly Gly Arg Glu Gly Ala Ser Trp Ala Arg Val Ser Leu Leu Arg Glu 
    50                  55                  60                  


Glu Leu Tyr Ala Arg Leu Ala Pro Arg Leu Tyr Ala Leu Glu Gly Glu 
65                  70                  75                  80  


Glu Val Arg Leu Gly Pro Pro Phe Arg Val Arg Ala Val Leu Gln Glu 
                85                  90                  95      


Gly His Pro Trp Ala Gly Val Ser Thr Tyr Pro Arg Leu Phe Gln Gly 
            100                 105                 110         


Pro Pro Ser Arg Asp Leu Ala Leu Arg Phe Ala Ser Pro Thr Phe Phe 
        115                 120                 125             


Arg Arg Lys Gly Val His Tyr Pro Val Pro Glu Pro Arg Leu Val Leu 
    130                 135                 140                 


Glu Ser Leu Leu Arg Arg Leu Glu Ala Phe Gly Pro Leu Lys Ala Pro 
145                 150                 155                 160 


Glu Gly Val Arg Glu Ala Leu Leu Glu Arg Thr Thr Val Arg Ser Leu 
                165                 170                 175     


Glu Gly Arg Thr Leu Pro Ala Arg Thr Glu Val Asp Thr Ala Gly Phe 
            180                 185                 190         


Val Gly Arg Val Val Tyr His Leu Pro Arg Ala Thr Glu Glu Glu Ala 
        195                 200                 205             


Leu Trp Leu Ser Ala Leu Gly Arg Phe Ala Phe Tyr Ser Gly Val Gly 
    210                 215                 220                 


Ala Lys Thr Ser Leu Gly Tyr Gly Arg Ala Arg Ala Glu Ser Pro 
225                 230                 235                 


<210>  21
<211>  236
<212>  PRT
<213>  Thermus sp. CCB_US3_UF1

<400>  21

Met Leu Ala Ala Leu Val Leu Thr Leu Glu Gly Glu Ala Pro Pro Glu 
1               5                   10                  15      


Pro Arg Gly Leu Arg Gly Phe Phe Tyr Gly Leu Leu Gln Glu Val Ala 
            20                  25                  30          


Pro Glu Val His Asp Gln Gly Glu Asn Pro Phe Ala Leu Gly Phe Gly 
        35                  40                  45              


Gly Lys Glu Gly Ala Tyr Trp Ala Arg Phe Ser Leu Leu Gln Glu Gly 
    50                  55                  60                  


Leu Tyr Ala Arg Leu Ala Pro Arg Leu Phe Ala Leu Glu Gly Lys Glu 
65                  70                  75                  80  


Val Arg Leu Gly Lys Pro Phe Arg Val Arg Gly Val Leu Gln Glu Gly 
                85                  90                  95      


His Pro Trp Ala Gly Val Ser Thr Tyr Ala Arg Leu Phe Gln Gly Glu 
            100                 105                 110         


Ala Leu Pro Asp Leu Pro Leu Arg Phe Ala Ser Pro Thr Phe Phe Arg 
        115                 120                 125             


Arg Lys Gly Val His Tyr Pro Leu Pro Glu Pro Arg Leu Val Val Glu 
    130                 135                 140                 


Ser Leu Leu Arg Arg Leu Glu Ala Phe Gly Pro Leu Lys Ala Pro Glu 
145                 150                 155                 160 


Gly Val Arg Glu Ala Leu Leu Glu Arg Thr Thr Val Arg Trp Phe Glu 
                165                 170                 175     


Gly Lys Thr Leu Lys Ala Glu Thr Glu Val Glu Ala Val Gly Phe Val 
            180                 185                 190         


Gly Lys Val Val Tyr His Leu Pro Arg Ala Thr Glu Glu Glu Ala Arg 
        195                 200                 205             


Trp Leu Gln Ala Leu Gly Arg Phe Ala Phe Tyr Ser Gly Val Gly Ala 
    210                 215                 220                 


Lys Thr Gly Leu Gly Tyr Gly Arg Ala Arg Val Gly 
225                 230                 235     


<210>  22
<211>  247
<212>  PRT
<213>  Thermus aquaticus Y51MC23

<400>  22

Met Val Leu Val Ala Leu Val Leu Val Leu Glu Gly Glu Gly Pro Pro 
1               5                   10                  15      


Glu Pro Leu Gly Leu Arg Gly Phe Phe Tyr Thr Leu Leu Lys Glu Ala 
            20                  25                  30          


Phe Pro Glu Leu His Asp Gln Gly Glu Asn Pro Phe Ala Leu Gly Phe 
        35                  40                  45              


Gly Leu Arg Gly Gly Glu Pro Trp Ala Arg Val Ser Leu Leu Arg Glu 
    50                  55                  60                  


Asp Leu Tyr Gly Arg Leu Ser Pro Ala Leu Phe Gly Leu Glu Gly Arg 
65                  70                  75                  80  


Glu Val Arg Leu Gly Arg Leu Phe Arg Val Arg Ala Val Leu Gln Glu 
                85                  90                  95      


Gly His Pro Trp Ala Gly Leu Thr Thr Tyr Ala Arg Leu Phe Gln Gly 
            100                 105                 110         


Pro His Ser Pro Asn Leu Pro Leu Arg Phe Tyr Ser Pro Thr Phe Phe 
        115                 120                 125             


Arg Arg Lys Gly Val Gln Tyr Pro Leu Pro Glu Pro Arg Leu Val Leu 
    130                 135                 140                 


Glu Ser Leu Leu Arg Arg Leu Glu Ala Phe Gly Pro Leu Lys Ala Pro 
145                 150                 155                 160 


Gln Glu Val Arg Glu Ala Leu Leu Glu Arg Thr Thr Val Arg Phe Leu 
                165                 170                 175     


Glu Gly Arg Thr Gln Met Ala Arg Thr Glu Val Asp Thr Val Gly Phe 
            180                 185                 190         


Val Gly Lys Val Val Tyr His Leu Pro Lys Ala Thr Glu Glu Glu Ala 
        195                 200                 205             


Leu Trp Leu Ser Ala Leu Gly Arg Tyr Ala Phe Phe Ser Gly Val Gly 
    210                 215                 220                 


Ala Lys Thr Ser Leu Gly Tyr Gly Leu Ala Arg Ala Phe Thr Gln Val 
225                 230                 235                 240 


Gly Pro Gln Asp Ala Glu Thr 
                245         


<210>  23
<211>  251
<212>  PRT
<213>  Marinithermus hydrothermalis DSM 14884

<400>  23

Met Leu Leu Ala Ala Leu Val Leu Pro Leu Glu Gly Pro Asp Arg Pro 
1               5                   10                  15      


Gln Pro Leu His Ala Arg Gly Trp Val Tyr Arg Leu Leu Arg Glu Ala 
            20                  25                  30          


Ala Pro Glu Ile His Asp Ala Glu Gly Pro Lys Pro Phe Thr Val Gly 
        35                  40                  45              


Val Gly Gly Arg Pro Asn Ala Val Trp Val Arg Leu Thr Cys Leu Ala 
    50                  55                  60                  


Glu Glu Val Tyr Ala Ala Leu Ser Pro Arg Leu Trp Ser Gln Val Gly 
65                  70                  75                  80  


Leu Glu Val Arg Leu Gly Glu Asp Thr Tyr Arg Ile Lys Ala Val Leu 
                85                  90                  95      


Glu Ala Glu His Pro Trp Ala Gly Leu Ala Thr Trp Pro Arg Leu Phe 
            100                 105                 110         


Gln Gly Glu Ala Gly Pro Asp Leu Gly Leu Glu Phe Ala Ser Pro Thr 
        115                 120                 125             


Phe Phe Arg Arg Gln Gly Ala Asn Tyr Pro Leu Pro Glu Pro Arg Leu 
    130                 135                 140                 


Val Leu Gly Ser Leu Ile Glu Arg Trp Asn Ala His Ala Pro Thr Pro 
145                 150                 155                 160 


Val Pro Pro Glu Val Ala Glu Arg Leu Val Glu Ala Thr Thr Leu Arg 
                165                 170                 175     


Tyr Leu Lys Gly His Thr Val Ser Ala Val Gly His Asp Arg Thr Val 
            180                 185                 190         


Gly Phe Arg Gly Arg Val Thr Tyr His Leu Pro Arg Ala Ser Thr Glu 
        195                 200                 205             


Glu Ala Arg Trp Leu Ala Ala Leu Gly Arg Phe Ala Phe Phe Ser Gly 
    210                 215                 220                 


Val Gly Ala Lys Thr Thr Leu Gly Phe Gly Gln Val Arg Pro Tyr Pro 
225                 230                 235                 240 


Leu Leu Ala Pro Ser Ala Ala Pro Pro Gly Pro 
                245                 250     


<210>  24
<211>  264
<212>  PRT
<213>  Thermus thermophilus HB8

<400>  24

Met Pro Gln Ala Val Val Leu Glu Leu Val Gly Glu Lys Pro Pro Leu 
1               5                   10                  15      


Tyr Pro Ala Arg Tyr Ala His Gly Leu Phe Phe Ala Leu Leu Ser Arg 
            20                  25                  30          


Val Ser Pro Glu Leu Ala Gln Lys Leu His Glu Ala Pro Arg Lys Pro 
        35                  40                  45              


Phe Thr Leu Ala Pro Leu Pro Arg Ala Gly Pro Glu Gly Ala Thr Leu 
    50                  55                  60                  


Lys Gly Thr Leu Arg Leu Arg Leu Thr Thr Leu Asp Asp Gly Leu Phe 
65                  70                  75                  80  


Ala Pro Phe Leu Arg Ala Leu Leu Glu Ala Ala Pro Asp Gly Leu Pro 
                85                  90                  95      


Leu Gly Asp Ser Ser Tyr Arg Leu Ala Arg Val Leu Ala Thr Arg Glu 
            100                 105                 110         


Gly His Pro Leu Ala Gly Ala Thr Ser Trp Glu Glu Leu Lys Glu Ala 
        115                 120                 125             


Pro Lys Arg Glu Lys Ala Thr Phe Arg Phe Leu Thr Pro Thr Val Phe 
    130                 135                 140                 


Ala Thr Ser Lys Pro Gly Gly Arg Thr Arg Tyr Thr Pro Leu Pro Asp 
145                 150                 155                 160 


Pro Arg Leu Ile Ala Gly Ser Leu Leu Asp Lys Trp Gln Ala His Ser 
                165                 170                 175     


Pro Phe Pro Tyr Asn Pro Lys Glu Glu Ala Ala Leu Arg Glu Leu Phe 
            180                 185                 190         


Glu Leu Asp Leu Glu Val Ala Gly Phe Arg Asn Leu Arg Phe His Arg 
        195                 200                 205             


Val Gln Ala Gly Lys Gly Phe Phe Pro Gly Phe Thr Gly Glu Ala Thr 
    210                 215                 220                 


Leu Arg Leu Trp Ser Gln Ser Leu Glu Ala Gln Glu Ala Leu Gly Arg 
225                 230                 235                 240 


Leu His Ala Leu Ala Phe Phe Ser Gly Val Gly Ala Lys Thr Pro Tyr 
                245                 250                 255     


Gly Met Gly Leu Ala Val Pro Leu 
            260                 


<210>  25
<211>  264
<212>  PRT
<213>  Thermus thermophilus HB27

<400>  25

Met Pro Gln Ala Val Val Leu Glu Leu Val Gly Glu Lys Pro Pro Leu 
1               5                   10                  15      


Tyr Pro Ala Arg Tyr Ala His Gly Leu Phe Phe Ala Leu Leu Ser Arg 
            20                  25                  30          


Val Ser Pro Glu Leu Ala Gln Lys Leu His Glu Ala Pro Arg Lys Pro 
        35                  40                  45              


Phe Thr Leu Ala Pro Leu Pro Arg Ala Gly Pro Glu Gly Ala Thr Leu 
    50                  55                  60                  


Lys Gly Thr Leu Arg Leu Arg Leu Thr Thr Leu Asp Asp Gly Leu Phe 
65                  70                  75                  80  


Ala Pro Phe Leu Arg Ala Leu Leu Glu Ala Ala Pro Asp Gly Leu Pro 
                85                  90                  95      


Leu Gly Asp Ser Ser Tyr Arg Leu Ala Arg Val Leu Ala Thr Arg Glu 
            100                 105                 110         


Gly His Pro Leu Ala Gly Ala Thr Ser Trp Glu Glu Leu Lys Glu Ala 
        115                 120                 125             


Pro Lys Arg Glu Lys Val Thr Phe Arg Phe Leu Thr Pro Thr Val Phe 
    130                 135                 140                 


Ala Thr Ser Lys Pro Gly Gly Arg Thr Arg Tyr Thr Pro Leu Pro Asp 
145                 150                 155                 160 


Pro Arg Leu Ile Ala Gly Ser Leu Leu Asp Lys Trp Gln Ala His Ser 
                165                 170                 175     


Pro Phe Pro Tyr Asn Pro Lys Glu Glu Ala Ala Leu Arg Gly Leu Phe 
            180                 185                 190         


Glu Leu Asp Leu Glu Val Ala Gly Phe Arg Asn Leu Arg Phe His Arg 
        195                 200                 205             


Val Gln Ala Gly Lys Gly Phe Phe Pro Gly Phe Thr Gly Glu Met Thr 
    210                 215                 220                 


Leu Arg Leu Trp Ser Gln Ser Leu Glu Ala Arg Glu Ala Leu Gly Arg 
225                 230                 235                 240 


Leu His Ala Leu Ala Phe Phe Ser Gly Val Gly Ala Lys Thr Pro Tyr 
                245                 250                 255     


Gly Met Gly Leu Ala Val Pro Leu 
            260                 


<210>  26
<211>  264
<212>  PRT
<213>  Thermus thermophilus SG0.5JP17-16

<400>  26

Met Pro Gln Ala Val Val Leu Glu Leu Val Gly Glu Lys Pro Pro Leu 
1               5                   10                  15      


Tyr Pro Gly Arg Tyr Ala His Gly Leu Phe Phe Ala Leu Leu Ser Arg 
            20                  25                  30          


Val Ser Pro Glu Leu Ala Gln Lys Leu His Glu Ala Pro Arg Lys Pro 
        35                  40                  45              


Phe Thr Leu Ala Pro Leu Pro Arg Val Gly Pro Glu Gly Ala Thr Leu 
    50                  55                  60                  


Lys Gly Ile Leu Arg Leu Arg Leu Thr Ala Leu Asp Asp Gly Leu Phe 
65                  70                  75                  80  


Ala Pro Phe Leu Arg Ala Leu Leu Glu Ala Ala Pro Asp Gly Leu Pro 
                85                  90                  95      


Leu Gly Asp Ser Ser Tyr Arg Leu Ala Arg Val Leu Ala Thr Arg Glu 
            100                 105                 110         


Gly His Pro Leu Ala Gly Ala Thr Ser Trp Glu Glu Leu Lys Glu Ala 
        115                 120                 125             


Pro Lys Arg Glu Lys Ala Thr Phe Arg Phe Leu Thr Pro Thr Val Phe 
    130                 135                 140                 


Ala Thr Ser Lys Pro Gly Gly Arg Thr Arg Tyr Thr Pro Leu Pro Asp 
145                 150                 155                 160 


Pro Arg Leu Ile Ala Gly Ser Leu Leu Asp Lys Trp Gln Ala His Ser 
                165                 170                 175     


Pro Phe Pro Tyr Asn Pro Lys Glu Glu Ala Ala Leu Arg Glu Leu Phe 
            180                 185                 190         


Glu Leu Asp Leu Glu Val Ala Gly Phe Arg Asn Leu Arg Phe His Arg 
        195                 200                 205             


Val Gln Ala Gly Lys Gly Phe Phe Pro Gly Phe Thr Gly Glu Ala Thr 
    210                 215                 220                 


Leu Arg Leu Trp Ser Gln Ser Leu Glu Ala Gln Glu Ala Leu Gly Arg 
225                 230                 235                 240 


Leu His Ala Leu Ala Phe Phe Ser Gly Val Gly Ala Lys Thr Pro Tyr 
                245                 250                 255     


Gly Met Gly Leu Ala Val Pro Leu 
            260                 


<210>  27
<211>  264
<212>  PRT
<213>  Thermus thermophilus JL-18

<400>  27

Met Pro Gln Ala Val Val Leu Glu Leu Val Gly Glu Glu Ser Pro Leu 
1               5                   10                  15      


Tyr Pro Ala Arg Tyr Ala His Gly Leu Phe Phe Ala Leu Leu Ser Arg 
            20                  25                  30          


Val Ser Pro Glu Leu Ala Gln Lys Leu His Glu Ala Pro Arg Lys Pro 
        35                  40                  45              


Phe Thr Leu Ala Pro Leu Pro Arg Val Gly Ser Glu Gly Ala Thr Leu 
    50                  55                  60                  


Lys Gly Ile Leu Arg Leu Arg Leu Thr Ile Leu Asp Asp Gly Leu Phe 
65                  70                  75                  80  


Ala Pro Phe Leu Arg Ala Leu Leu Glu Ala Ala Pro Asp Gly Leu Pro 
                85                  90                  95      


Leu Gly Asp Ser Ser Tyr Arg Leu Ala Arg Val Leu Ala Thr Arg Glu 
            100                 105                 110         


Gly His Pro Leu Ala Gly Ala Thr Ser Trp Glu Glu Leu Lys Glu Ala 
        115                 120                 125             


Pro Lys Arg Glu Lys Ala Thr Phe Arg Phe Leu Thr Pro Thr Val Phe 
    130                 135                 140                 


Ala Thr Ser Lys Pro Gly Gly Arg Thr Arg Tyr Thr Pro Leu Pro Asp 
145                 150                 155                 160 


Pro Arg Leu Ile Ala Gly Ser Leu Leu Asp Lys Trp Gln Ala His Ser 
                165                 170                 175     


Pro Phe Pro Tyr Asn Pro Lys Glu Glu Ala Ala Leu Arg Glu Leu Phe 
            180                 185                 190         


Glu Leu Asp Leu Glu Val Ala Gly Phe Arg Asn Leu Arg Phe His Arg 
        195                 200                 205             


Val Gln Ala Gly Lys Ser Phe Phe Pro Gly Phe Thr Gly Glu Met Thr 
    210                 215                 220                 


Leu Arg Leu Trp Ser Gln Ser Leu Glu Ala Gln Gly Ala Leu Gly Arg 
225                 230                 235                 240 


Leu His Ala Leu Ala Phe Phe Ser Gly Val Gly Ala Lys Thr Pro Tyr 
                245                 250                 255     


Gly Met Gly Leu Ala Val Pro Leu 
            260                 


<210>  28
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  28
auugagcccc guaaggggau                                                   20


<210>  29
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  29
cguuagccuc guagaggau                                                    19


<210>  30
<211>  24
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  30
uacccacccc gaagaaaagg ggac                                              24


<210>  31
<211>  244
<212>  PRT
<213>  Staphylococcus epidermidis RP62A

<400>  31

Met Ile Asn Lys Ile Thr Val Glu Leu Asp Leu Pro Glu Ser Ile Arg 
1               5                   10                  15      


Phe Gln Tyr Leu Gly Ser Val Leu His Gly Val Leu Met Asp Tyr Leu 
            20                  25                  30          


Ser Asp Asp Ile Ala Asp Gln Leu His His Glu Phe Ala Tyr Ser Pro 
        35                  40                  45              


Leu Lys Gln Arg Ile Tyr His Lys Asn Lys Lys Ile Ile Trp Glu Ile 
    50                  55                  60                  


Val Cys Met Ser Asp Asn Leu Phe Lys Glu Val Val Lys Leu Phe Ser 
65                  70                  75                  80  


Ser Lys Asn Ser Leu Leu Leu Lys Tyr Tyr Gln Thr Asn Ile Asp Ile 
                85                  90                  95      


Gln Ser Phe Gln Ile Glu Lys Ile Asn Val Gln Asn Met Met Asn Gln 
            100                 105                 110         


Leu Leu Gln Val Glu Asp Leu Ser Arg Tyr Val Arg Leu Asn Ile Gln 
        115                 120                 125             


Thr Pro Met Ser Phe Lys Tyr Gln Asn Ser Tyr Met Ile Phe Pro Asp 
    130                 135                 140                 


Val Lys Arg Phe Phe Arg Ser Ile Met Ile Gln Phe Asp Ala Phe Phe 
145                 150                 155                 160 


Glu Glu Tyr Arg Met Tyr Asp Lys Glu Thr Leu Asn Phe Leu Glu Lys 
                165                 170                 175     


Asn Val Asn Ile Val Asp Tyr Lys Leu Lys Ser Thr Arg Phe Asn Leu 
            180                 185                 190         


Glu Lys Val Lys Ile Pro Ser Phe Thr Gly Glu Ile Val Phe Lys Ile 
        195                 200                 205             


Lys Gly Pro Leu Pro Phe Leu Gln Leu Thr His Phe Leu Leu Lys Phe 
    210                 215                 220                 


Gly Glu Phe Ser Gly Ser Gly Ile Lys Thr Ser Leu Gly Met Gly Lys 
225                 230                 235                 240 


Tyr Ser Ile Ile 
                


<210>  32
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  32
ccaaaacccc gagaggggac                                                   20


<210>  33
<211>  314
<212>  PRT
<213>  Mycobacterium tuberculosis H37Rv

<400>  33

Met Ala Ala Arg Arg Gly Gly Ile Arg Arg Thr Asp Leu Leu Arg Arg 
1               5                   10                  15      


Ser Gly Gln Pro Arg Gly Arg His Arg Ala Ser Ala Ala Glu Ser Gly 
            20                  25                  30          


Leu Thr Trp Ile Ser Pro Thr Leu Ile Leu Val Gly Phe Ser His Arg 
        35                  40                  45              


Gly Asp Arg Arg Met Thr Glu His Leu Ser Arg Leu Thr Leu Thr Leu 
    50                  55                  60                  


Glu Val Asp Ala Pro Leu Glu Arg Ala Arg Val Ala Thr Leu Gly Pro 
65                  70                  75                  80  


His Leu His Gly Val Leu Met Glu Ser Ile Pro Ala Asp Tyr Val Gln 
                85                  90                  95      


Thr Leu His Thr Val Pro Val Asn Pro Tyr Ser Gln Tyr Ala Leu Ala 
            100                 105                 110         


Arg Ser Thr Thr Ser Leu Glu Trp Lys Ile Ser Thr Leu Thr Asn Glu 
        115                 120                 125             


Ala Arg Gln Gln Ile Val Gly Pro Ile Asn Asp Ala Ala Phe Ala Gly 
    130                 135                 140                 


Phe Arg Leu Arg Ala Ser Gly Ile Ala Thr Gln Val Thr Ser Arg Ser 
145                 150                 155                 160 


Leu Glu Gln Asn Pro Leu Ser Gln Phe Ala Arg Ile Phe Tyr Ala Arg 
                165                 170                 175     


Pro Glu Thr Arg Lys Phe Arg Val Glu Phe Leu Thr Pro Thr Ala Phe 
            180                 185                 190         


Lys Gln Ser Gly Glu Tyr Val Phe Trp Pro Asp Pro Arg Leu Val Phe 
        195                 200                 205             


Gln Ser Leu Ala Gln Lys Tyr Gly Ala Ile Val Asp Gly Glu Glu Pro 
    210                 215                 220                 


Asp Pro Gly Leu Ile Ala Glu Phe Gly Gln Ser Val Arg Leu Ser Ala 
225                 230                 235                 240 


Phe Arg Val Ala Ser Ala Pro Phe Ala Val Gly Ala Ala Arg Val Pro 
                245                 250                 255     


Gly Phe Thr Gly Ser Ala Thr Phe Thr Val Arg Gly Val Asp Thr Phe 
            260                 265                 270         


Ala Ser Tyr Ile Ala Ala Leu Leu Trp Phe Gly Glu Phe Ser Gly Cys 
        275                 280                 285             


Gly Ile Lys Ala Ser Met Gly Met Gly Ala Ile Arg Val Gln Pro Leu 
    290                 295                 300                 


Ala Pro Arg Glu Lys Cys Val Pro Lys Pro 
305                 310                 


<210>  34
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  34
uaauuaccuc gagaggggac                                                   20


<210>  35
<211>  243
<212>  PRT
<213>  Streptococcus thermophilus LMG 18311

<400>  35

Met Lys Lys Leu Val Phe Thr Phe Lys Arg Ile Asp His Pro Ala Gln 
1               5                   10                  15      


Asp Leu Ala Val Lys Phe His Gly Phe Leu Met Glu Gln Leu Asp Ser 
            20                  25                  30          


Asp Tyr Val Asp Tyr Leu His Gln Gln Gln Thr Asn Pro Tyr Ala Thr 
        35                  40                  45              


Lys Val Ile Gln Gly Lys Glu Asn Thr Gln Trp Val Val His Leu Leu 
    50                  55                  60                  


Thr Asp Asp Ile Glu Asp Lys Val Phe Met Thr Leu Leu Gln Ile Lys 
65                  70                  75                  80  


Glu Val Ser Leu Asn Asp Leu Pro Lys Leu Ser Val Glu Lys Val Glu 
                85                  90                  95      


Ile Gln Glu Leu Gly Ala Asp Lys Leu Leu Glu Ile Phe Asn Ser Glu 
            100                 105                 110         


Glu Asn Gln Thr Tyr Phe Ser Ile Ile Phe Glu Thr Pro Thr Gly Phe 
        115                 120                 125             


Lys Ser Gln Gly Ser Tyr Val Ile Phe Pro Ser Met Arg Leu Ile Phe 
    130                 135                 140                 


Gln Ser Leu Met Gln Lys Tyr Gly Arg Leu Val Glu Asn Gln Pro Glu 
145                 150                 155                 160 


Ile Glu Glu Asp Thr Leu Asp Tyr Leu Ser Glu His Ser Thr Ile Thr 
                165                 170                 175     


Asn Tyr Arg Leu Glu Thr Ser Tyr Phe Arg Val His Arg Gln Arg Ile 
            180                 185                 190         


Pro Ala Phe Arg Gly Lys Leu Thr Phe Lys Val Gln Gly Ala Gln Thr 
        195                 200                 205             


Leu Lys Ala Tyr Val Lys Met Leu Leu Thr Phe Gly Glu Tyr Ser Gly 
    210                 215                 220                 


Leu Gly Met Lys Thr Ser Leu Gly Met Gly Gly Ile Lys Leu Glu Glu 
225                 230                 235                 240 


Arg Lys Asp 
            


<210>  36
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  36
cagucaccuc gggaggggac                                                   20


<210>  37
<211>  244
<212>  PRT
<213>  Streptococcus sanguinis SK36

<400>  37

Met Lys Lys Ile Arg Leu His Leu Ser Lys Val Ser Leu Lys Asp Asp 
1               5                   10                  15      


Asp Leu Val Cys Lys Leu Gln Gly Phe Leu Met Glu Lys Leu Ser Asp 
            20                  25                  30          


Asp Phe Ala Ser Phe Leu His Gln Gln Glu Thr Asn Pro Tyr Ser Met 
        35                  40                  45              


Asn Leu Arg Ser Glu Arg Glu Glu Ser Ile Trp Thr Val Asn Leu Leu 
    50                  55                  60                  


Ser Glu Glu Ala Glu Gln Gln Ile Leu Pro Gln Leu Leu Ser Leu Glu 
65                  70                  75                  80  


Met Ile Lys Leu Glu Thr Tyr Ser Glu Glu Ile Leu Val Lys Asn Ile 
                85                  90                  95      


Glu Ile Gln Ser Leu Ser Ser Gln Ser Leu Leu Glu Val Phe Gln Gly 
            100                 105                 110         


Asp Glu Ala Ser His Leu Ile Ser Leu Asn Phe Tyr Thr Pro Thr Thr 
        115                 120                 125             


Phe Lys Arg Gln Gly Gln Phe Val Leu Phe Pro Asp Thr Arg Leu Ile 
    130                 135                 140                 


Phe Gln Ser Leu Met Gln Lys Tyr Ser Arg Leu Val Glu Gly Lys Ala 
145                 150                 155                 160 


Glu Ile Glu Glu Glu Thr Leu Glu Phe Leu Ala Glu His Ser Gln Ile 
                165                 170                 175     


Ser Ser Tyr Arg Leu Lys Ser His Tyr Phe Pro Ile His Gly Arg Lys 
            180                 185                 190         


Tyr Pro Ala Phe Glu Gly Arg Val Thr Ile Arg Ile Gln Gly Ala Ser 
        195                 200                 205             


Thr Leu Lys Ala Tyr Ala Gln Met Leu Leu Arg Phe Gly Glu Tyr Ser 
    210                 215                 220                 


Gly Val Gly Ala Lys Cys Ser Leu Gly Met Gly Gly Met Arg Ile Glu 
225                 230                 235                 240 


Glu Arg Lys Thr 
                


<210>  38
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  38
cuuaaacccu auuagggau                                                    19


<210>  39
<211>  277
<212>  PRT
<213>  Microcystis aeruginosa NIES-843

<400>  39

Met Pro Tyr Ser Leu Val Leu Asn Leu Thr Pro Arg Ser Pro Ile Tyr 
1               5                   10                  15      


Pro Asn Phe Leu Thr Gly Arg His Leu His Ala Leu Phe Leu Thr Leu 
            20                  25                  30          


Val Ser Ser Val Asp Gln Glu Leu Gly Lys Ile Leu His Thr Ala Glu 
        35                  40                  45              


Ala Asp Lys Ala Phe Thr Leu Ser Pro Leu Gln Met Gln Ser Gly Gly 
    50                  55                  60                  


Lys Thr Ile Asn Ser Pro Gln Trp Arg Tyr Glu Arg Pro Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Pro Cys Trp Trp Arg Ile Ser Leu Leu Asp Asp Arg Leu Phe 
                85                  90                  95      


Gly Lys Leu Thr Pro Leu Trp Leu Asn Leu Asn Pro Lys His Pro Trp 
            100                 105                 110         


His Leu Gly Ser Ala Asp Leu Val Ile Thr Ser Val Leu Ala Thr Pro 
        115                 120                 125             


Gln Ser Val Gln Pro Trp Ala Asn Ser Cys Thr Tyr Gln Tyr Leu Tyr 
    130                 135                 140                 


Glu Asn Ala Ser Glu Thr Asn Arg Glu Phe Asp Phe Leu Phe Ala Thr 
145                 150                 155                 160 


Pro Val Thr Phe Arg Gln Gly Lys Phe Asp Ser Ala Leu Pro Thr Arg 
                165                 170                 175     


Glu Leu Val Phe Asn Ser Leu Leu Asn Arg Trp Asn Arg Tyr Ser Ala 
            180                 185                 190         


Ile Pro Phe Asp Ser Ile Val Leu Glu Ser Ile Phe Pro Ser Phe Phe 
        195                 200                 205             


Asp Ile Gln Thr Lys Leu Ala Asp Glu Ala Tyr Lys Asn Gln Ser Phe 
    210                 215                 220                 


Gly Cys Val Gly Glu Ile His Tyr Arg Leu Leu Gly Glu Val Glu Pro 
225                 230                 235                 240 


Ala Lys Ile Lys Ala Ile Asn Val Leu Ala Asp Phe Ala Leu Tyr Ala 
                245                 250                 255     


Gly Val Gly Arg Lys Thr Thr Met Gly Met Gly Met Thr Arg Arg Ile 
            260                 265                 270         


Ala Lys Glu Lys Arg 
        275         


<210>  40
<211>  32
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  40
gucgcccccc acgcgggggc guggauugaa ac                                     32


<210>  41
<211>  227
<212>  PRT
<213>  Desulfovibrio vulgaris DP4

<400>  41

Met Thr His Gly Ala Val Lys Thr Tyr Gly Ile Arg Leu Arg Val Trp 
1               5                   10                  15      


Gly Asp Tyr Ala Cys Phe Thr Arg Pro Glu Met Lys Val Glu Arg Val 
            20                  25                  30          


Ser Tyr Asp Val Met Thr Pro Ser Ala Ala Arg Gly Ile Leu Glu Ala 
        35                  40                  45              


Ile His Trp Lys Pro Ala Ile Arg Trp Ile Val Asp Arg Ile His Val 
    50                  55                  60                  


Leu Arg Pro Ile Val Phe Asp Asn Val Arg Arg Asn Glu Val Ser Ser 
65                  70                  75                  80  


Lys Ile Pro Lys Pro Asn Pro Ala Thr Ala Met Arg Asp Arg Lys Pro 
                85                  90                  95      


Leu Tyr Phe Leu Val Asp Asp Gly Ser Asn Arg Gln Gln Arg Ala Ala 
            100                 105                 110         


Thr Leu Leu Arg Asn Val Asp Tyr Val Ile Glu Ala His Phe Glu Leu 
        115                 120                 125             


Thr Asp Lys Ala Gly Ala Glu Asp Asn Ala Gly Lys His Leu Asp Ile 
    130                 135                 140                 


Phe Arg Arg Arg Ala Arg Ala Gly Gln Ser Phe Gln Gln Pro Cys Leu 
145                 150                 155                 160 


Gly Cys Arg Glu Phe Pro Ala Ser Phe Glu Leu Leu Glu Gly Asp Val 
                165                 170                 175     


Pro Leu Ser Cys Tyr Ala Gly Glu Lys Arg Asp Leu Gly Tyr Met Leu 
            180                 185                 190         


Leu Asp Ile Asp Phe Glu Arg Asp Met Thr Pro Leu Phe Phe Lys Ala 
        195                 200                 205             


Val Met Glu Asp Gly Val Ile Thr Pro Pro Ser Arg Thr Ser Pro Glu 
    210                 215                 220                 


Val Arg Ala 
225         


<210>  42
<211>  227
<212>  PRT
<213>  Methylomonas methanica MC09

<400>  42

Met Ala Tyr Gly Ile Lys Leu His Ile Trp Gly Asp Tyr Ala Cys Phe 
1               5                   10                  15      


Thr Arg Pro Glu Met Lys Val Glu Arg Val Ser Tyr Asp Val Ile Thr 
            20                  25                  30          


Pro Ser Ala Ala Arg Gly Ile Leu Glu Ala Ile His Trp Lys Pro Ala 
        35                  40                  45              


Ile Arg Trp Val Ile Asp Lys Ile His Val Leu Gln Pro Val Arg Phe 
    50                  55                  60                  


Glu Ser Ile Arg Arg Asn Glu Val Gly Ser Lys Ile Ser Ala Ala Lys 
65                  70                  75                  80  


Ile Lys Thr Ala Met Arg Asn Gln Ser Thr Gln Asp Leu Tyr Leu Val 
                85                  90                  95      


Ala Asp Asp Ala Lys Glu Arg Gln Gln Arg Ala Ser Thr Val Leu Arg 
            100                 105                 110         


Asn Val Ala Tyr Ile Ile Glu Ala His Phe Glu Leu Thr Asp Leu Ala 
        115                 120                 125             


Thr Asp Glu Asp Asn Glu Gly Lys His Leu Asp Ile Phe Asn Arg Arg 
    130                 135                 140                 


Ala Arg Lys Gly Gln Cys Phe Gln Gln Pro Cys Met Gly Val Arg Glu 
145                 150                 155                 160 


Phe Pro Ala Tyr Phe Ala Leu Ile Glu Pro Glu Gln Ser Leu Pro Glu 
                165                 170                 175     


Ser Glu Leu Thr Pro Glu Gln Leu Asn Arg Asp Leu Gly Trp Met Leu 
            180                 185                 190         


His Asp Ile Asp Phe Ala Asn Gly Met Met Pro His Phe Phe Lys Ala 
        195                 200                 205             


Glu Leu Lys Gly Gly Ile Ile Thr Val Pro Asp Phe Tyr Ser Glu Gly 
    210                 215                 220                 


Val Lys Ala 
225         


<210>  43
<211>  227
<212>  PRT
<213>  Nitrosomonas sp. AL212

<400>  43

Met Ala Tyr Gly Ile Lys Leu His Ile Trp Gly Asp Tyr Ala Cys Phe 
1               5                   10                  15      


Thr Arg Pro Glu Met Lys Val Glu Arg Val Ser Tyr Asp Val Ile Thr 
            20                  25                  30          


Pro Ser Ala Ala Arg Gly Ile Leu Asp Ala Ile His Trp Lys Pro Ala 
        35                  40                  45              


Ile Arg Trp Val Ile Asp Lys Ile His Val Leu Arg Pro Val Arg Phe 
    50                  55                  60                  


Glu Ser Ile Arg Arg Asn Glu Val Gly Ser Lys Ile Ser Ala Asn Lys 
65                  70                  75                  80  


Ile Lys Thr Ala Met Arg Asn Gln Ser Thr Gln Asp Leu Tyr Leu Val 
                85                  90                  95      


Ala Asp Asp Ser Lys Glu Arg Gln Gln Arg Ala Ser Thr Val Leu Arg 
            100                 105                 110         


Asn Val Ala Tyr Ile Ile Glu Ala His Phe Glu Leu Thr Asp Leu Ala 
        115                 120                 125             


Ser Glu Glu Asp Ser Glu Gly Lys His Leu Asp Ile Phe Asn Arg Arg 
    130                 135                 140                 


Ala Arg Lys Gly Gln Cys Phe Gln Gln Pro Cys Met Gly Val Arg Glu 
145                 150                 155                 160 


Phe Pro Ala Tyr Phe Ser Leu Ile Glu Pro Glu Glu Ser Leu Pro Glu 
                165                 170                 175     


Ser Glu Leu Thr Leu Glu Gln Leu Asn Arg Asp Leu Gly Trp Met Leu 
            180                 185                 190         


His Asp Ile Asp Phe Ala Asn Glu Met Met Pro Arg Phe Phe Lys Ala 
        195                 200                 205             


Glu Leu Lys Asn Gly Val Ile Thr Val Pro Asp Phe Tyr Ser Asp Glu 
    210                 215                 220                 


Val Lys Ala 
225         


<210>  44
<211>  225
<212>  PRT
<213>  Vibrio metschnikovii CIP 69.14

<400>  44

Met Ala Tyr Gly Ile Lys Leu His Val Trp Gly Glu Tyr Ala Cys Phe 
1               5                   10                  15      


Thr Arg Pro Glu Met Lys Val Glu Arg Val Ser Tyr Asp Val Ile Thr 
            20                  25                  30          


Pro Ser Ala Ala Arg Gly Ile Leu Glu Ala Ile His Trp Lys Pro Ala 
        35                  40                  45              


Ile Ile Trp Val Ile Asp Arg Ile His Val Leu Lys Pro Val Arg Phe 
    50                  55                  60                  


Glu Ser Ile Arg Arg Asn Glu Leu Gly Asn Cys Lys Val Ser Ser Ala 
65                  70                  75                  80  


Lys Val Ser Gly Ala Met Lys Arg Lys Ser Thr Gln Asp Leu Ser Phe 
                85                  90                  95      


Leu Ile Asp Asp Gly Asp Asn Arg Gln Gln Arg Ala Thr Thr Leu Leu 
            100                 105                 110         


Arg Asp Val Ser Tyr Val Ile Glu Ala His Phe Glu Leu Ser Asp Lys 
        115                 120                 125             


Ala Gly Thr Glu Asp Ser Ile Gly Lys His Leu Asp Ile Phe Asn Arg 
    130                 135                 140                 


Arg Ala Arg Arg Gly Gln Tyr Phe His Gln Pro Cys Leu Gly Asn Arg 
145                 150                 155                 160 


Glu Phe Pro Ala Tyr Phe Ser Leu Ile Glu His Glu Trp Asp Phe Pro 
                165                 170                 175     


Lys Ser Glu Leu Ala Thr Ala Ser Lys Asp Leu Gly Trp Met Leu His 
            180                 185                 190         


Asp Ile Asp Phe Ala Asn Gly Ala Glu Pro Arg Phe Phe Arg Ala Glu 
        195                 200                 205             


Leu Lys Asp Gly Met Ile Asp Val Pro Pro Phe Arg Ser Ser Lys Val 
    210                 215                 220                 


Val 
225 


<210>  45
<211>  218
<212>  PRT
<213>  Desulfotomaculum carboxydivorans CO-1-SRB

<400>  45

Met Gly Tyr Gly Ile Lys Leu Lys Val Trp Gly Asp Tyr Ala Cys Phe 
1               5                   10                  15      


Ser Arg Pro Glu Met Lys Val Glu Arg Val Ser Tyr Asp Val Met Thr 
            20                  25                  30          


Pro Ser Ala Ala Arg Gly Ile Leu Glu Ala Ile His Trp Lys Pro Ala 
        35                  40                  45              


Ile Arg Trp Val Val Asp Arg Ile His Ile Leu Asn Ala Phe Lys Phe 
    50                  55                  60                  


Glu Asn Ile Arg Arg Asn Glu Val Gly Thr Lys Ile Pro Ala Gly Thr 
65                  70                  75                  80  


Val Lys Thr Ala Met Lys Gly Gln Pro Val Met Leu Cys Gln Tyr Ala 
                85                  90                  95      


Ser Asn Glu Arg Gln Gln Arg Ala Thr Leu Leu Leu Lys Asp Val Ala 
            100                 105                 110         


Tyr Val Ile Glu Ala His Phe Glu Met Thr Asp Lys Ala Gly Pro Thr 
        115                 120                 125             


Asp Thr Glu Glu Lys His Tyr Asn Met Phe Leu Arg Arg Ala Arg Thr 
    130                 135                 140                 


Gly Gln Cys Phe His Arg Pro Tyr Leu Gly Cys Arg Glu Phe Pro Ala 
145                 150                 155                 160 


His Phe Glu Leu Leu Glu Gly Glu Asn Pro Ile Ser Val His Arg Gly 
                165                 170                 175     


Glu Lys Asp Leu Gly Trp Met Leu Leu Asp Ile Asp Tyr Lys Asn Asn 
            180                 185                 190         


Met Glu Pro His Phe Phe Arg Ala Val Met Gln Asp Gly Val Val Thr 
        195                 200                 205             


Val Pro Pro Leu Lys Gly Gly Gly Ser Leu 
    210                 215             


<210>  46
<211>  224
<212>  PRT
<213>  Neisseria mucosa ATCC 25996

<400>  46

Met Asn Gln Ile Arg Leu His Val Trp Gly Asp Tyr Ala Cys Phe Thr 
1               5                   10                  15      


Arg Pro Glu Met Lys Val Glu Arg Val Ser Tyr Asp Val Ile Thr Pro 
            20                  25                  30          


Ser Ala Ala Arg Gly Ile Leu Ala Ala Val His Trp Lys Pro Ala Ile 
        35                  40                  45              


Arg Trp Val Ile Asp Arg Ile Tyr Val Leu Lys Pro Ile Arg Phe Glu 
    50                  55                  60                  


Ser Val Arg Arg Asn Glu Leu Gly Gly Lys Ile Ser Ala Gly Lys Val 
65                  70                  75                  80  


Ser Gly Ala Met Lys Arg Lys Ser Val Ala Asp Leu Tyr Thr Leu Ile 
                85                  90                  95      


Glu Asp Asp Arg Gln Gln Arg Ala Ala Thr Val Leu Lys Asp Val Ala 
            100                 105                 110         


Tyr Val Ile Glu Ala His Ala Val Leu Thr Ala Lys Ala Gly Ala Asp 
        115                 120                 125             


Glu Thr Val Thr Lys His Ile Glu Met Phe Lys Arg Arg Ala Lys Lys 
    130                 135                 140                 


Gly Gln Cys Phe Gln Gln Pro Cys Leu Gly Val Arg Glu Phe Pro Ala 
145                 150                 155                 160 


Asp Phe Ala Leu Ile Asp Glu Gly Glu Pro Leu Pro Pro Ser Ala Leu 
                165                 170                 175     


Ser Glu Ser Glu Ala Asn Arg Asp Leu Gly Trp Met Leu His Asp Ile 
            180                 185                 190         


Asp Phe Asp His Gly Asn Thr Pro His Phe Phe Arg Ala Gln Met Lys 
        195                 200                 205             


Asp Gly Val Ile Asp Val Pro Pro Phe Tyr Ala Glu Glu Val Lys Ala 
    210                 215                 220                 


<210>  47
<211>  236
<212>  PRT
<213>  Bacillus halodurans C-125

<400>  47

Met Arg Asn Glu Val Gln Phe Glu Leu Phe Gly Asp Tyr Ala Leu Phe 
1               5                   10                  15      


Thr Asp Pro Leu Thr Lys Ile Gly Gly Glu Lys Leu Ser Tyr Ser Val 
            20                  25                  30          


Pro Thr Tyr Gln Ala Leu Lys Gly Ile Ala Glu Ser Ile Tyr Trp Lys 
        35                  40                  45              


Pro Thr Ile Val Phe Val Ile Asp Glu Leu Arg Val Met Lys Pro Ile 
    50                  55                  60                  


Gln Met Glu Ser Lys Gly Val Arg Pro Ile Glu Tyr Gly Gly Gly Asn 
65                  70                  75                  80  


Thr Leu Ala His Tyr Thr Tyr Leu Lys Asp Val His Tyr Gln Val Lys 
                85                  90                  95      


Ala His Phe Glu Phe Asn Leu His Arg Pro Asp Leu Ala Phe Asp Arg 
            100                 105                 110         


Asn Glu Gly Lys His Tyr Ser Ile Leu Gln Arg Ser Leu Lys Ala Gly 
        115                 120                 125             


Gly Arg Arg Asp Ile Phe Leu Gly Ala Arg Glu Cys Gln Gly Tyr Val 
    130                 135                 140                 


Ala Pro Cys Glu Phe Gly Ser Gly Asp Gly Phe Tyr Asp Gly Gln Gly 
145                 150                 155                 160 


Lys Tyr His Leu Gly Thr Met Val His Gly Phe Asn Tyr Pro Asp Glu 
                165                 170                 175     


Thr Gly Gln His Gln Leu Asp Val Arg Leu Trp Ser Ala Val Met Glu 
            180                 185                 190         


Asn Gly Tyr Ile Gln Phe Pro Arg Pro Glu Asp Cys Pro Ile Val Arg 
        195                 200                 205             


Pro Val Lys Glu Met Glu Pro Lys Ile Phe Asn Pro Asp Asn Val Gln 
    210                 215                 220                 


Ser Ala Glu Gln Leu Leu His Asp Leu Gly Gly Glu 
225                 230                 235     


<210>  48
<211>  246
<212>  PRT
<213>  Bacillus cereus F65185

<400>  48

Met Lys Lys Glu Glu Glu Ser Leu Arg Asn Ser Ile Glu Phe Glu Val 
1               5                   10                  15      


Phe Gly Asp Tyr Ala Leu Phe Thr Asp Pro Leu Met Lys Met Gly Gly 
            20                  25                  30          


Glu Lys Leu Thr Tyr Gln Val Pro Thr Tyr Gln Ala Ile Lys Gly Ile 
        35                  40                  45              


Val Glu Ser Ile Tyr Trp Lys Pro Thr Leu Leu Met Ile Val Asp Lys 
    50                  55                  60                  


Ile Arg Ile Met Asn Ala Ile Lys Met Glu Ser Lys Gly Ile Arg Pro 
65                  70                  75                  80  


Ile Glu Tyr Gly Gly Gly Asn Thr Leu Ala Asn Tyr Thr Tyr Leu Lys 
                85                  90                  95      


Asn Val Arg Tyr Gln Val Gln Ala His Phe Ile Phe Asn Pro His Arg 
            100                 105                 110         


Pro Asp Leu Ala Phe Asp Arg Asn Glu Tyr Lys His His Asn Ile Leu 
        115                 120                 125             


Lys Arg Ser Leu Lys Val Gly Gly Arg Arg Asp Ile Phe Leu Gly Thr 
    130                 135                 140                 


Arg Glu Cys Gln Gly Tyr Val Glu Pro Cys Val Phe Gly Glu Gly Glu 
145                 150                 155                 160 


Gly Phe Tyr Asp Asn Tyr Gly Gly Asp Ile His Leu Gly Thr Met Val 
                165                 170                 175     


His Gly Leu Asn Tyr Pro Asp Glu Thr Gly Arg Asn Glu Leu Glu Val 
            180                 185                 190         


Arg Leu Trp Asn Pro Val Met Arg Asp Gly Ile Ile Gln Phe Ile Arg 
        195                 200                 205             


Pro Glu Glu Cys Thr Lys Ile Arg Lys Ile Ser Lys Met Glu Pro Lys 
    210                 215                 220                 


Ile Phe Asp Ser Ser Asn Val Glu Ser Val Asp Glu Leu Ile Lys Gln 
225                 230                 235                 240 


Leu Glu Glu Gly Gly Glu 
                245     


<210>  49
<211>  239
<212>  PRT
<213>  Selenomonas noxia ATCC 43541

<400>  49

Met Arg Asn Ser Ile Glu Phe Gln Val Tyr Gly Arg Met Ala Leu Phe 
1               5                   10                  15      


Thr Asp Pro Ile Thr Lys Ile Gly Gly Glu Lys Ala Ser Tyr Ser Val 
            20                  25                  30          


Pro Thr Tyr Gln Ala Leu Lys Gly Ile Thr Glu Ser Ile Tyr Trp Lys 
        35                  40                  45              


Pro Thr Ile Ile Trp Phe Ile Asp Glu Val Arg Val Met Lys Arg Ile 
    50                  55                  60                  


Thr Thr Gln Val Arg Gly Val Lys Pro Leu Lys Tyr Gly Asp Ser Gly 
65                  70                  75                  80  


Asn Asp Leu Ser Tyr Tyr Lys Tyr Leu Ser Asp Val Cys Tyr Gln Val 
                85                  90                  95      


Arg Ala His Phe Glu Phe Asn Met His Arg Glu Glu Leu Lys Glu Asp 
            100                 105                 110         


Arg Asp Glu His Lys His His Asn Ile Ala Lys Arg Met Val Glu Arg 
        115                 120                 125             


Gly Gly Arg Arg Asp Ile Phe Leu Gly Thr Arg Glu Cys Gln Gly Tyr 
    130                 135                 140                 


Val Glu Pro Val Lys Tyr Gly Val Gly Lys Gly Tyr Tyr Asp Asn Val 
145                 150                 155                 160 


Asp Glu Leu Pro Leu Gly Ile Met Leu His Gly Phe Asn Tyr Pro Asp 
                165                 170                 175     


Glu Thr Gly Glu Asp Lys Leu Gln Val Arg Phe Trp Lys Pro Thr Met 
            180                 185                 190         


Lys Lys Gly Ile Ile His Phe Arg Arg Pro Glu Lys Cys Glu Met Val 
        195                 200                 205             


Arg Asp Ile Arg Glu Val Arg Thr Lys Gln Phe Asp Ala Asp Asn Val 
    210                 215                 220                 


Phe Phe Ala Glu Glu Glu Glu Lys Gln Leu Glu Gly Gly His Leu 
225                 230                 235                 


<210>  50
<211>  33
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  50
gucgcgcccc gcauggggcg cguggauuga aac                                    33


<210>  51
<211>  66
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence


<220>
<221>  misc_feature
<222>  (22)..(66)
<223>  n in any of these positions can be any base (e.g., a,g,c,t) and 
       can be present or absent such that this entire region may be 
       absent. This region may also be of any desired length (e.g., 
       4,000 "n"s, 3000 "n"s, 2,500 "n"s, etc.).

<400>  51
gucgcccccc acgcgggggc gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnn                                                                  66


<210>  52
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  52
gucgcccccc acgcgggggc g                                                 21


<210>  53
<211>  30
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  53
guugcaaggg auugagcccc guaaggggau                                        30


<210>  54
<211>  30
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  54
guugcaaacc ucguuagccu cguagaggau                                        30


<210>  55
<211>  29
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  55
guagucccca cgcguguggg gauggaccg                                         29


<210>  56
<211>  14
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  56
ccccguaagg ggau                                                         14


<210>  57
<211>  18
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  57
gguugcaagg ggauugag                                                     18


<210>  58
<211>  244
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  58

His His His His Gly Ser Arg Phe Leu Ile Arg Leu Val Pro Glu Asp 
1               5                   10                  15      


Lys Asp Arg Ala Phe Lys Val Pro Tyr Asn His Gln Tyr Tyr Leu Gln 
            20                  25                  30          


Gly Leu Ile Tyr Asn Ala Ile Lys Ser Ser Asn Pro Lys Leu Ala Thr 
        35                  40                  45              


Tyr Leu His Glu Val Lys Gly Pro Lys Leu Phe Thr Tyr Ser Leu Phe 
    50                  55                  60                  


Met Ala Glu Lys Arg Glu His Pro Lys Gly Leu Pro Tyr Phe Leu Gly 
65                  70                  75                  80  


Tyr Lys Lys Gly Phe Phe Tyr Phe Ser Thr Cys Val Pro Glu Ile Ala 
                85                  90                  95      


Glu Ala Leu Val Asn Gly Leu Leu Met Asn Pro Glu Val Arg Leu Trp 
            100                 105                 110         


Asp Glu Arg Phe Tyr Leu His Glu Ile Lys Val Leu Arg Glu Pro Lys 
        115                 120                 125             


Lys Phe Asn Gly Ser Thr Phe Val Thr Leu Ser Pro Ile Ala Val Thr 
    130                 135                 140                 


Val Val Arg Lys Gly Lys Ser Tyr Asp Val Pro Pro Met Glu Lys Glu 
145                 150                 155                 160 


Phe Tyr Ser Ile Ile Lys Asp Asp Leu Gln Asp Lys Tyr Val Met Ala 
                165                 170                 175     


Tyr Gly Asp Lys Pro Pro Ser Glu Phe Glu Met Glu Val Leu Ile Ala 
            180                 185                 190         


Lys Pro Lys Arg Phe Arg Ile Lys Pro Gly Ile Tyr Gln Thr Ala Trp 
        195                 200                 205             


His Leu Val Phe Arg Ala Tyr Gly Asn Asp Asp Leu Leu Lys Val Gly 
    210                 215                 220                 


Tyr Glu Val Gly Phe Gly Glu Lys Asn Ser Leu Gly Phe Gly Met Val 
225                 230                 235                 240 


Lys Val Glu Gly 
                


<210>  59
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  59

Gly Thr Gly Ala Met Trp Leu Thr Lys Leu Val Leu Asn Pro Ala Ser 
1               5                   10                  15      


Arg Ala Ala Arg Arg Asp Leu Ala Asn Pro Tyr Glu Met His Arg Thr 
            20                  25                  30          


Leu Ser Lys Ala Val Ser Arg Ala Leu Glu Glu Gly Arg Glu Arg Leu 
        35                  40                  45              


Leu Trp Arg Leu Glu Pro Ala Arg Gly Leu Glu Pro Pro Val Val Leu 
    50                  55                  60                  


Val Gln Thr Leu Thr Glu Pro Asp Trp Ser Val Leu Asp Glu Gly Tyr 
65                  70                  75                  80  


Ala Gln Val Phe Pro Pro Lys Pro Phe His Pro Ala Leu Lys Pro Gly 
                85                  90                  95      


Gln Arg Leu Arg Phe Arg Leu Arg Ala Asn Pro Ala Lys Arg Leu Ala 
            100                 105                 110         


Ala Thr Gly Lys Arg Val Ala Leu Lys Thr Pro Ala Glu Lys Val Ala 
        115                 120                 125             


Trp Leu Glu Arg Arg Leu Glu Glu Gly Gly Phe Arg Leu Leu Glu Gly 
    130                 135                 140                 


Glu Arg Gly Pro Trp Val Gln Ile Leu Gln Asp Thr Phe Leu Glu Val 
145                 150                 155                 160 


Arg Arg Lys Lys Asp Gly Glu Glu Ala Gly Lys Leu Leu Gln Val Gln 
                165                 170                 175     


Ala Val Leu Phe Glu Gly Arg Leu Glu Val Val Asp Pro Glu Arg Ala 
            180                 185                 190         


Leu Ala Thr Leu Arg Arg Gly Val Gly Pro Gly Lys Ala Leu Gly Leu 
        195                 200                 205             


Gly Leu Leu Ser Val Ala Pro 
    210                 215 


<210>  60
<211>  188
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  60

Thr Met Asp His Tyr Leu Asp Ile Arg Leu Arg Pro Asp Pro Glu Phe 
1               5                   10                  15      


Pro Pro Ala Gln Leu Met Ser Val Leu Phe Gly Lys Leu His Gln Ala 
            20                  25                  30          


Leu Val Ala Gln Gly Gly Asp Arg Ile Gly Val Ser Phe Pro Asp Leu 
        35                  40                  45              


Asp Glu Ser Arg Ser Arg Leu Gly Glu Arg Leu Arg Ile His Ala Ser 
    50                  55                  60                  


Ala Asp Asp Leu Arg Ala Leu Leu Ala Arg Pro Trp Leu Glu Gly Leu 
65                  70                  75                  80  


Arg Asp His Leu Gln Phe Gly Glu Pro Ala Val Val Pro His Pro Thr 
                85                  90                  95      


Pro Tyr Arg Gln Val Ser Arg Val Gln Ala Lys Ser Asn Pro Glu Arg 
            100                 105                 110         


Leu Arg Arg Arg Leu Met Arg Arg His Asp Leu Ser Glu Glu Glu Ala 
        115                 120                 125             


Arg Lys Arg Ile Pro Asp Thr Val Ala Arg Ala Leu Asp Leu Pro Phe 
    130                 135                 140                 


Val Thr Leu Arg Ser Gln Ser Thr Gly Gln His Phe Arg Leu Phe Ile 
145                 150                 155                 160 


Arg His Gly Pro Leu Gln Val Thr Ala Glu Glu Gly Gly Phe Thr Cys 
                165                 170                 175     


Tyr Gly Leu Ser Lys Gly Gly Phe Val Pro Trp Phe 
            180                 185             


