                         SEQUENCE LISTING

<110>  NUCLEA BIOTECHNOLOGIES, INC
 
<120>  Predictive Markers For Cancer and Metabolic Syndrome

<130>  2015.1008PCT/NUC-068-PCT

<140>  PCT/USXX/XXXXX
<141>  2013-06-XX

<150>  US 61/660,018
<151>  2012-06-15

<150>  US 61/727,323
<151>  2012-11-16

<150>  US 61/766,931
<151>  2013-02-20

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1017
<212>  DNA
<213>  Homo sapiens

<400>  1
cccttggcca gcgagatgct ttgacacagc cccttaagat gttttaaggg ctatcccata       60

aagccgggaa ggcacaacgg gtggagctgg cggccgccgg gggcaggcac ttttgagcta      120

aggaggaagc gggggaggga aggagggcgg gaaggacgcg ccacctactt cctgaatccc      180

ctgcaaaccc cagaggagct cggcctgcgc tgcgccacga tgtccgggga gtcagccagg      240

agcttgggga agggaagcgc gcccccgggg ccggtcccgg agggctcgat ccgcatctac      300

agcatgaggt tctgcccgtt tgctgagagg acgcgtctag tcctgaaggc caagggaatc      360

aggcatgaag tcatcaatat caacctgaaa aataagcctg agtggttctt taagaaaaat      420

ccctttggtc tggtgccagt tctggaaaac agtcagggtc agctgatcta cgagtctgcc      480

atcacctgtg agtacctgga tgaagcatac ccagggaaga agctgttgcc ggatgacccc      540

tatgagaaag cttgccagaa gatgatctta gagttgtttt ctaaggtgcc atccttggta      600

ggaagcttta ttagaagcca aaataaagaa gactatgctg gcctaaaaga agaatttcgt      660

aaagaattta ccaagctaga ggaggttctg actaataaga agacgacctt ctttggtggc      720

aattctatct ctatgattga ttacctcatc tggccctggt ttgaacggct ggaagcaatg      780

aagttaaatg agtgtgtaga ccacactcca aaactgaaac tgtggatggc agccatgaag      840

gaagatccca cagtctcagc cctgcttact agtgagaaag actggcaagg tttcctagag      900

ctctacttac agaacagccc tgaggcctgt gactatgggc tctgaagggg gcaggagtca      960

gcaataaagc tatgtctgat attttccttc actaatatga ataaaaaaaa aaaaaaa        1017


<210>  2
<211>  1593
<212>  DNA
<213>  Homo sapiens

<400>  2
gcggtgccct tgcggcgcag ctggggtcgc ggccctgctc cccgcgcttt cttaaggccc       60

gcgggcggcg caggagcggc actcgtggct gtggtggctt cggcagcggc ttcagcagat      120

cggcggcatc agcggtagca ccagcactag cagcatgttg agccgggcag tgtgcggcac      180

cagcaggcag ctggctccgg ttttggggta tctgggctcc aggcagaagc acagcctccc      240

cgacctgccc tacgactacg gcgccctgga acctcacatc aacgcgcaga tcatgcagct      300

gcaccacagc aagcaccacg cggcctacgt gaacaacctg aacgtcaccg aggagaagta      360

ccaggaggcg ttggccaagg gagatgttac agcccagata gctcttcagc ctgcactgaa      420

gttcaatggt ggtggtcata tcaatcatag cattttctgg acaaacctca gccctaacgg      480

tggtggagaa cccaaagggg agttgctgga agccatcaaa cgtgactttg gttcctttga      540

caagtttaag gagaagctga cggctgcatc tgttggtgtc caaggctcag gttggggttg      600

gcttggtttc aataaggaac ggggacactt acaaattgct gcttgtccaa atcaggatcc      660

actgcaagga acaacaggcc ttattccact gctggggatt gatgtgtggg agcacgctta      720

ctaccttcag tataaaaatg tcaggcctga ttatctaaaa gctatttgga atgtaatcaa      780

ctgggagaat gtaactgaaa gatacatggc ttgcaaaaag taaaccacga tcgttatgct      840

gagtatgtta agctctttat gactgttttt gtagtggtat agagtactgc agaatacagt      900

aagctgctct attgtagcat ttcttgatgt tgcttagtca cttatttcat aaacaactta      960

atgttctgaa taatttctta ctaaacattt tgttattggg caagtgattg aaaatagtaa     1020

atgctttgtg tgattgaatc tgattggaca ttttcttcag agagctaaat tacaattgtc     1080

atttataaaa ccatcaaaaa tattccatcc atatactttg gggacttgta gggatgcctt     1140

tctagtccta ttctattgca gttatagaaa atctagtctt ttgccccagt tacttaaaaa     1200

taaaatatta acactttccc aagggaaaca ctcggctttc tatagaaaat tgcacttttt     1260

gtcgagtaat cctctgcagt gatacttctg gtagatgtca cccagtggtt tttgttaggt     1320

caaatgttcc tgtatagttt ttgcaaatag agctgtatac tgtttaaatg tagcaggtga     1380

actgaactgg ggtttgctca cctgcacagt aaaggcaaac ttcaacagca aaactgcaaa     1440

aaggtggttt ttgcagtagg agaaaggagg atgtttattt gcagggcgcc aagcaaggag     1500

aattgggcag ctcatgcttg agacccaatc tccatgatga cctacaagct agagtattta     1560

aaggcagtgg taaatttcag gaaagcagaa gtt                                  1593


<210>  3
<211>  809
<212>  DNA
<213>  Homo sapiens

<400>  3
gtaaggtgaa ggtgcccagc aggctgaggc ttgtgtgcaa cccagaagag agctcgctaa       60

cgccagcaag aaggttcaga acagcctggc tttggaaagg aatttcatcc tgcccacaca      120

ctgcatagca ggagggaagc atgtctactt tatccaattt cacacagacg ctggaagacg      180

tcttccgaag gatttttatt acttatatgg acaattggcg ccagaacaca acagctgagc      240

aagaggccct ccaagccaaa gttgatgctg agaacttcta ctatgtcatc ctgtacctca      300

tggtgatgat tggaatgttc tctttcatca tcgtggccat cctggtgagc actgtgaaat      360

ccaagagacg ggaacactcc aatgacccct accaccagta cattgtagag gactggcagg      420

aaaagtacaa gagccaaatc ttgaatctag aagaatcgaa ggccaccatc catgagaaca      480

ttggtgcggc tgggttcaaa atgtccccct gataagggag aaaggcacca agctaacatc      540

tgacgtccag acatgaagag atgccagtgc cacgaggcaa atccaaattg tctttgctta      600

gaagaaagtg agttccttgc tctctgttga gaattttcat ggagattatg tggttggcca      660

ataaagatag atgacatttc aatctcagtg atttatgctt gcttgttgga gcaatatttt      720

gtgctgaaga cctcttttac tttccgggca agtgaatgtc attttaatca atatcaatga      780

tgaaaataaa gccaaatttg aagaaaaaa                                        809


<210>  4
<211>  1922
<212>  DNA
<213>  Homo sapiens

<400>  4
ctgtgagatc accccgtgct cccagcgctc acgtcggtcc tcggaaagcc ggggtcctcc       60

ctgccttttc cagcaacggt ggggtgggga ggcaggaaga aagcgccaac ctaggacccc      120

ggagatttgc agcaaaggaa gaagcgggag acgggcactt gtctgtgtct ccagcgcgtt      180

cctgcccccc gccgacccgg cccatttcta tacaaggtcg ctctgcccgg tctccacctc      240

ccacgtgcag gccgcggagg ggctcattcc cgggccctga tctcagaggc ccggaatgtg      300

gctgataaat cagagactag acctgcatgg caggcaggcc cgacactcag ctccaggata      360

aaaggccacg gtgtcccgag gagccaggag gagcaccccg caggctgagg gcaggtggga      420

agcaaacccg gacgcatcgc agcagcagca gcagcagcag aagcagcagc agcagcctcc      480

gcagtccctc cagagacatg gatccccaga cagcaccttc ccgggcgctc ctgctcctgc      540

tcttcttgca tctggctttc ctgggaggtc gttcccaccc gctgggcagc cccggttcag      600

cctcggactt ggaaacgtcc gggttacagg tgagagcgga gggcagctca gggggattgg      660

acagcagcaa tgaaagggtc ctcacctgct gtcccaagag gccctcatct ttcctttgga      720

attagtgata aaggaatcag aaaatggaga gactgggtgc cctgaccctg tacccaaggc      780

agtcggttca cttgggtgcc atgaagggct ggtgagccag gggtgggtcc ctgaggcttg      840

gacgccccca ttcattgcag gagcagcgca accatttgca gggcaaactg tcggagctgc      900

aggtggagca gacatccctg gagcccctcc aggagagccc ccgtcccaca ggtgtctgga      960

agtcccggga ggtagccacc gagggcatcc gtgggcaccg caaaatggtc ctctacaccc     1020

tgcgggcacc acgaagcccc aagatggtgc aagggtctgg ctgctttggg aggaagatgg     1080

accggatcag ctcctccagt ggcctgggct gcaaaggtaa gcaccccctg ccaccccggc     1140

cgccttcccc cattccagtg tgtgacactg ttagagtcac tttggggttt gttgtctctg     1200

ggaaccacac tctttgagaa aaggtcacct ggacatcgct tcctcttgtt aacagccttc     1260

agggccaagg ggtgcctttg tggaattagt aaatgtgggc ttatttcatt accatgccca     1320

caataccttc tccccacctc ctacttctta tcaaaggggc agaatctcct ttgggggtct     1380

gtttatcatt tggcagcccc ccagtggtgc agaaagagaa ccaaacattt cctcctggtt     1440

tcctctaaac tgtctatagt ctcaaaggca gagagcagga tcaccagagc aatgataatc     1500

cccaatttac agatgaggaa actgaggctc agagagttgc attaagcctc aaacgtctga     1560

tgactaacag ggtggtgggt ggcacacgat gaggtaagct cagcccctgc ctccatctcc     1620

caccctaacc atcatcaccc tctctctttc cctgacagtg ctgaggcggc attaagagga     1680

agtcctggct gcagacacct gcttctgatt ccacaagggg ctttttcctc aaccctgtgg     1740

ccgcctttga agtgactcat tttttttaat gtatttatgt atttatttga ttgttttata     1800

taagatggtt tcttaccttt gagcacaaaa tttccacggt gaaataaagt caacattata     1860

agctttatct tttgaaactg atttgtcttg gcgcattaaa aataatccct catttcaaag     1920

aa                                                                    1922


<210>  5
<211>  1070
<212>  DNA
<213>  Homo sapiens

<400>  5
aaggatgact cctagacctg tctttgtccc atacttggga agataagctg ttagtttaca       60

ttgccaagat gaaattcaac tgatctgttt tagagtaaag atcttgcggg ccaacaagga      120

atttccttgg ggaggtgtgt ggcctttgat ctttgtagct atttagcaac aaaatgggag      180

gcagtgttgc ctgactcagt ttccaagctt gactcttccc tttggcatag tgagtttgga      240

gtcaagagat ttttattttc ccttcacaag ctgaacagga gcctttggag agaacgctct      300

ggaccggaag cgcgcccccg gggccggtcc cggagggctc gatccgcatc tacagcatga      360

ggttctgccc gtttgctgag aggacgcgtc tagtcctgaa ggccaaggga atcaggcatg      420

aagtcatcaa tatcaacctg aaaaataagc ctgagtggtt ctttaagaaa aatccctttg      480

gtctggtgcc agttctggaa aacagtcagg gtcagctgat ctacgagtct gccatcacct      540

gtgagtacct ggatgaagca tacccaggga agaagctgtt gccggatgac ccctatgaga      600

aagcttgcca gaagatgatc ttagagttgt tttctaaggt gccatccttg gtaggaagct      660

ttattagaag ccaaaataaa gaagactatg ctggcctaaa agaagaattt cgtaaagaat      720

ttaccaagct agaggaggtt ctgactaata agaagacgac cttctttggt ggcaattcta      780

tctctatgat tgattacctc atctggccct ggtttgaacg gctggaagca atgaagttaa      840

atgagtgtgt agaccacact ccaaaactga aactgtggat ggcagccatg aaggaagatc      900

ccacagtctc agccctgctt actagtgaga aagactggca aggtttccta gagctctact      960

tacagaacag ccctgaggcc tgtgactatg ggctctgaag ggggcaggag tcagcaataa     1020

agctatgtct gatattttcc ttcactaata tgaataaaaa aaaaaaaaaa                1070


<210>  6
<211>  918
<212>  DNA
<213>  Homo sapiens

<400>  6
cccttggcca gcgagatgct ttgacacagc cccttaagat gttttaaggg ctatcccata       60

aagccgggaa ggcacaacgg gtggagctgg cggccgccgg gggcaggcac ttttgagcta      120

aggaggaagc gggggaggga aggagggcgg gaaggacgcg ccacctactt cctgaatccc      180

ctgcaaaccc cagaggagct cggcctgcgc tgcgccacga tgtccgggga gtcagccagg      240

agcttgggga agggaagcgc gcccccgggg ccggtcccgg agggctcgat ccgcatctac      300

agcatgaggt tctgcccgtt tgctgagagg acgcgtctag tcctgaaggc caagggaatc      360

aggcatgaag tcatcaatat caacctgaaa aataagcctg agtggttctt taagaaaaat      420

ccctttggtc tggtgccagt tctggaaaac agtcagggtc agctgatcta cgagtctgcc      480

atcacctgtg agtacctgga tgaagcatac ccagggaaga agctgttgcc ggatgacccc      540

tatgagaaag cttgccagaa gatgatctta gagttgtttt ctaaggttct gactaataag      600

aagacgacct tctttggtgg caattctatc tctatgattg attacctcat ctggccctgg      660

tttgaacggc tggaagcaat gaagttaaat gagtgtgtag accacactcc aaaactgaaa      720

ctgtggatgg cagccatgaa ggaagatccc acagtctcag ccctgcttac tagtgagaaa      780

gactggcaag gtttcctaga gctctactta cagaacagcc ctgaggcctg tgactatggg      840

ctctgaaggg ggcaggagtc agcaataaag ctatgtctga tattttcctt cactaatatg      900

aataaaaaaa aaaaaaaa                                                    918


<210>  7
<211>  918
<212>  DNA
<213>  Homo sapiens

<400>  7
gcggtgccct tgcggcgcag ctggggtcgc ggccctgctc cccgcgcttt cttaaggccc       60

gcgggcggcg caggagcggc actcgtggct gtggtggctt cggcagcggc ttcagcagat      120

cggcggcatc agcggtagca ccagcactag cagcatgttg agccgggcag tgtgcggcac      180

cagcaggcag ctggctccgg ttttggggta tctgggctcc aggcagaagc acagcctccc      240

cgacctgccc tacgactacg gcgccctgga acctcacatc aacgcgcaga tcatgcagct      300

gcaccacagc aagcaccacg cggcctacgt gaacaacctg aacgtcaccg aggagaagta      360

ccaggaggcg ttggccaagg gggagttgct ggaagccatc aaacgtgact ttggttcctt      420

tgacaagttt aaggagaagc tgacggctgc atctgttggt gtccaaggct caggttgggg      480

ttggcttggt ttcaataagg aacggggaca cttacaaatt gctgcttgtc caaatcagga      540

tccactgcaa ggaacaacag gccttattcc actgctgggg attgatgtgt gggagcacgc      600

ttactacctt cagtataaaa atgtcaggcc tgattatcta aaagctattt ggaatgtaat      660

caactgggag aatgtaactg aaagatacat ggcttgcaaa aagtaaacca cgatcgttat      720

gctgatcata ccctaatgat cccagcaaga taatgtcctg tcttctaaga tgtgcatcaa      780

gcctggtaca tactgaaaac cctataaggt cctggataat ttttgtttga ttattcattg      840

aagaaacatt tattttccaa ttgtgtgaag tttttgactg ttaataaaag aatctgtcaa      900

ccatcaaaaa aaaaaaaa                                                    918


<210>  8
<211>  1035
<212>  DNA
<213>  Homo sapiens

<400>  8
gcggtgccct tgcggcgcag ctggggtcgc ggccctgctc cccgcgcttt cttaaggccc       60

gcgggcggcg caggagcggc actcgtggct gtggtggctt cggcagcggc ttcagcagat      120

cggcggcatc agcggtagca ccagcactag cagcatgttg agccgggcag tgtgcggcac      180

cagcaggcag ctggctccgg ttttggggta tctgggctcc aggcagaagc acagcctccc      240

cgacctgccc tacgactacg gcgccctgga acctcacatc aacgcgcaga tcatgcagct      300

gcaccacagc aagcaccacg cggcctacgt gaacaacctg aacgtcaccg aggagaagta      360

ccaggaggcg ttggccaagg gagatgttac agcccagata gctcttcagc ctgcactgaa      420

gttcaatggt ggtggtcata tcaatcatag cattttctgg acaaacctca gccctaacgg      480

tggtggagaa cccaaagggg agttgctgga agccatcaaa cgtgactttg gttcctttga      540

caagtttaag gagaagctga cggctgcatc tgttggtgtc caaggctcag gttggggttg      600

gcttggtttc aataaggaac ggggacactt acaaattgct gcttgtccaa atcaggatcc      660

actgcaagga acaacaggcc ttattccact gctggggatt gatgtgtggg agcacgctta      720

ctaccttcag tataaaaatg tcaggcctga ttatctaaaa gctatttgga atgtaatcaa      780

ctgggagaat gtaactgaaa gatacatggc ttgcaaaaag taaaccacga tcgttatgct      840

gatcataccc taatgatccc agcaagataa tgtcctgtct tctaagatgt gcatcaagcc      900

tggtacatac tgaaaaccct ataaggtcct ggataatttt tgtttgatta ttcattgaag      960

aaacatttat tttccaattg tgtgaagttt ttgactgtta ataaaagaat ctgtcaacca     1020

tcaaaaaaaa aaaaa                                                      1035


<210>  9
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  9
ccccgcaggc tgagggcagg tgggaagcaa acccggacgc atcgcagcag cagcagcagc       60

agcagaagca gcagcagcag cctccgcagt ccctccagag acatggatcc ccagacagca      120

ccttcccggg cgctcctgct cctgctcttc ttgcatctgg ctttcctggg aggtcgttcc      180

cacccgctgg gcagccccgg ttcagcctcg gacttggaaa cgtccgggtt acaggagcag      240

cgcaaccatt tgcagggcaa actgtcggag ctgcaggtgg agcagacatc cctggagccc      300

ctccaggaga gcccccgtcc cacaggtgtc tggaagtccc gggaggtagc caccgagggc      360

atccgtgggc accgcaaaat ggtcctctac accctgcggg caccacgaag ccccaagatg      420

gtgcaagggt ctggctgctt tgggaggaag atggaccgga tcagctcctc cagtggcctg      480

ggctgcaaag tgctgaggcg gcattaagag gaagtcctgg ctgcagacac ctgcttctga      540

ttccacaagg ggctttttcc tcaaccctgt ggccgccttt gaagtgactc atttttttaa      600

tgtatttatg tatttatttg attgttttat ataagatggt ttcttacctt tgagcacaaa      660

atttccacgg tgaaataaag tcaacattat aagctttaaa aaaaaaaa                   708


<210>  10
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Phe Cys Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala 
1               5                   10                  15      


Lys Gly Ile Arg His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro 
            20                  25                  30          


Glu Trp Phe Phe Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu 
        35                  40                  45              


Asn Ser Gln Gly Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr 
    50                  55                  60                  


Leu Asp Glu Ala Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr 
65                  70                  75                  80  


Glu Lys Ala Cys Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro 
                85                  90                  95      


Ser Leu Val Gly Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala 
            100                 105                 110         


Gly Leu Lys Glu Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val 
        115                 120                 125             


Leu Thr Asn Lys Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met 
    130                 135                 140                 


Ile Asp Tyr Leu Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys 
145                 150                 155                 160 


Leu Asn Glu Cys Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala 
                165                 170                 175     


Ala Met Lys Glu Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys 
            180                 185                 190         


Asp Trp Gln Gly Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala 
        195                 200                 205             


Cys Asp Tyr Gly Leu 
    210             


<210>  11
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
1               5                   10                  15      


Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
            20                  25                  30          


Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
        35                  40                  45              


His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
    50                  55                  60                  


Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
65                  70                  75                  80  


Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                85                  90                  95      


Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
            100                 105                 110         


Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly 
        115                 120                 125             


Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu 
    130                 135                 140                 


Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys 
145                 150                 155                 160 


Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu 
                165                 170                 175     


Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys 
            180                 185                 190         


Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu 
        195                 200                 205             


Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly 
    210                 215                 220                 


Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly 
225                 230                 235                 240 


Leu 
    


<210>  12
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
1               5                   10                  15      


Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
            20                  25                  30          


Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
        35                  40                  45              


His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
    50                  55                  60                  


Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
65                  70                  75                  80  


Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                85                  90                  95      


Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
            100                 105                 110         


Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Leu Thr Asn Lys Lys 
        115                 120                 125             


Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu Ile 
    130                 135                 140                 


Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys Val 
145                 150                 155                 160 


Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu Asp 
                165                 170                 175     


Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly Phe 
            180                 185                 190         


Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly Leu 
        195                 200                 205             


<210>  13
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Val 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala 
65                  70                  75                  80  


Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile 
                85                  90                  95      


Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu 
            100                 105                 110         


Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe 
        115                 120                 125             


Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly 
    130                 135                 140                 


Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln 
145                 150                 155                 160 


Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu 
                165                 170                 175     


Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln 
            180                 185                 190         


Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile 
        195                 200                 205             


Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys 
    210                 215                 220         


<210>  14
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Val 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Glu Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Lys Arg Asp Phe Gly Ser Phe Asp Lys Phe Lys Glu Lys Leu 
                85                  90                  95      


Thr Ala Ala Ser Val Gly Val Gln Gly Ser Gly Trp Gly Trp Leu Gly 
            100                 105                 110         


Phe Asn Lys Glu Arg Gly His Leu Gln Ile Ala Ala Cys Pro Asn Gln 
        115                 120                 125             


Asp Pro Leu Gln Gly Thr Thr Gly Leu Ile Pro Leu Leu Gly Ile Asp 
    130                 135                 140                 


Val Trp Glu His Ala Tyr Tyr Leu Gln Tyr Lys Asn Val Arg Pro Asp 
145                 150                 155                 160 


Tyr Leu Lys Ala Ile Trp Asn Val Ile Asn Trp Glu Asn Val Thr Glu 
                165                 170                 175     


Arg Tyr Met Ala Cys Lys Lys 
            180             


<210>  15
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg 
1               5                   10                  15      


Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln Asn Thr Thr Ala 
            20                  25                  30          


Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu Asn Phe Tyr Tyr 
        35                  40                  45              


Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ser Phe Ile Ile 
    50                  55                  60                  


Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser 
65                  70                  75                  80  


Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Glu Lys Tyr 
                85                  90                  95      


Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala Thr Ile His Glu 
            100                 105                 110         


Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro 
        115                 120             


<210>  16
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              


His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  


Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg 
65                  70                  75                  80  


Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr 
                85                  90                  95      


Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
            100                 105                 110         


Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys 
        115                 120                 125             


Lys Val Leu Arg Arg His 
    130                 


