                               SEQUENCE LISTING

<110> MEDIMMUNE, LLC.
 
<120> FIXED DOSAGE REGIMENS FOR ANTI-TYPE I INTERFERON RECEPTOR
      (IFNAR) ANTIBODIES

<130> IFNAR-310WO1

<140> PCT/US2013/045327
<141> 2013-06-12

<150> 61/659,138
<151> 2012-06-13

<160> 23    

<170> PatentIn version 3.5

<210> 1
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Cys Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Ile Glu Gly Phe Asp Tyr Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Ala 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 3
<211> 119
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Val Pro Met Val Leu 
        35                  40                  45              


Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser Ser Ile Ala 
    50                  55                  60                  


Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly Gly Val Ala 
65                  70                  75                  80  


Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Thr Gly Leu 
                85                  90                  95      


Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser Ala Ile Ala 
            100                 105                 110         


Ala Val Ile Ala Arg Phe Tyr 
        115                 


<210> 4
<211> 444
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Val Thr Thr Arg Leu Thr Trp Leu His Glu Lys Ile Leu Gln 
1               5                   10                  15      


Asn His Phe Gly Gly Lys Arg Leu Ser Leu Leu Tyr Lys Gly Ser Val 
            20                  25                  30          


His Gly Phe Arg Asn Gly Val Leu Leu Asp Arg Cys Cys Asn Gln Gly 
        35                  40                  45              


Pro Thr Leu Thr Val Ile Tyr Ser Glu Asp His Ile Ile Gly Ala Tyr 
    50                  55                  60                  


Ala Glu Glu Ser Tyr Gln Glu Gly Lys Tyr Ala Ser Ile Ile Leu Phe 
65                  70                  75                  80  


Ala Leu Gln Asp Thr Lys Ile Ser Glu Trp Lys Leu Gly Leu Cys Thr 
                85                  90                  95      


Pro Glu Thr Leu Phe Cys Cys Asp Val Thr Lys Tyr Asn Ser Pro Thr 
            100                 105                 110         


Asn Phe Gln Ile Asp Gly Arg Asn Arg Lys Val Ile Met Asp Leu Lys 
        115                 120                 125             


Thr Met Glu Asn Leu Gly Leu Ala Gln Asn Cys Thr Ile Ser Ile Gln 
    130                 135                 140                 


Asp Tyr Glu Val Phe Arg Cys Glu Asp Ser Leu Asp Glu Arg Lys Ile 
145                 150                 155                 160 


Lys Gly Val Ile Glu Leu Arg Lys Ser Leu Leu Ser Ala Leu Arg Thr 
                165                 170                 175     


Tyr Glu Pro Tyr Gly Ser Leu Val Gln Gln Ile Arg Ile Leu Leu Leu 
            180                 185                 190         


Gly Pro Ile Gly Ala Gly Lys Ser Ser Phe Phe Asn Ser Val Arg Ser 
        195                 200                 205             


Val Phe Gln Gly His Val Thr His Gln Ala Leu Val Gly Thr Asn Thr 
    210                 215                 220                 


Thr Gly Ile Ser Glu Lys Tyr Arg Thr Tyr Ser Ile Arg Asp Gly Lys 
225                 230                 235                 240 


Asp Gly Lys Tyr Leu Pro Phe Ile Leu Cys Asp Ser Leu Gly Leu Ser 
                245                 250                 255     


Glu Lys Glu Gly Gly Leu Cys Arg Asp Asp Ile Phe Tyr Ile Leu Asn 
            260                 265                 270         


Gly Asn Ile Arg Asp Arg Tyr Gln Phe Asn Pro Met Glu Ser Ile Lys 
        275                 280                 285             


Leu Asn His His Asp Tyr Ile Asp Ser Pro Ser Leu Lys Asp Arg Ile 
    290                 295                 300                 


His Cys Val Ala Phe Val Phe Asp Ala Ser Ser Ile Gln Tyr Phe Ser 
305                 310                 315                 320 


Ser Gln Met Ile Val Lys Ile Lys Arg Ile Arg Arg Glu Leu Val Asn 
                325                 330                 335     


Ala Gly Val Val His Val Ala Leu Leu Thr His Val Asp Ser Met Asp 
            340                 345                 350         


Leu Ile Thr Lys Gly Asp Leu Ile Glu Ile Glu Arg Cys Glu Pro Val 
        355                 360                 365             


Arg Ser Lys Leu Glu Glu Val Gln Arg Lys Leu Gly Phe Ala Leu Ser 
    370                 375                 380                 


Asp Ile Ser Val Val Ser Asn Tyr Ser Ser Glu Trp Glu Leu Asp Pro 
385                 390                 395                 400 


Val Lys Asp Val Leu Ile Leu Ser Ala Leu Arg Arg Met Leu Trp Ala 
                405                 410                 415     


Ala Asp Asp Phe Leu Glu Asp Leu Pro Phe Glu Gln Ile Gly Asn Leu 
            420                 425                 430         


Arg Glu Glu Ile Ile Asn Cys Ala Gln Gly Lys Lys 
        435                 440                 


<210> 5
<211> 452
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Val Thr Thr Arg Leu Thr Trp Asn Asp Glu Asn His Leu Arg 
1               5                   10                  15      


Lys Leu Leu Gly Asn Val Ser Leu Ser Leu Leu Tyr Lys Ser Ser Val 
            20                  25                  30          


His Gly Gly Ser Ile Glu Asp Met Val Glu Arg Cys Ser Arg Gln Gly 
        35                  40                  45              


Cys Thr Ile Thr Met Ala Tyr Ile Asp Tyr Asn Met Ile Val Ala Phe 
    50                  55                  60                  


Met Leu Gly Asn Tyr Ile Asn Leu His Glu Ser Ser Thr Glu Pro Asn 
65                  70                  75                  80  


Asp Ser Leu Trp Phe Ser Leu Gln Lys Lys Asn Asp Thr Thr Glu Ile 
                85                  90                  95      


Glu Thr Leu Leu Leu Asn Thr Ala Pro Lys Ile Ile Asp Glu Gln Leu 
            100                 105                 110         


Val Cys Arg Leu Ser Lys Thr Asp Ile Phe Ile Ile Cys Arg Asp Asn 
        115                 120                 125             


Lys Ile Tyr Leu Asp Lys Met Ile Thr Arg Asn Leu Lys Leu Arg Phe 
    130                 135                 140                 


Tyr Gly His Arg Gln Tyr Leu Glu Cys Glu Val Phe Arg Val Glu Gly 
145                 150                 155                 160 


Ile Lys Asp Asn Leu Asp Asp Ile Lys Arg Ile Ile Lys Ala Arg Glu 
                165                 170                 175     


His Arg Asn Arg Leu Leu Ala Asp Ile Arg Asp Tyr Arg Pro Tyr Ala 
            180                 185                 190         


Asp Leu Val Ser Glu Ile Arg Ile Leu Leu Val Gly Pro Val Gly Ser 
        195                 200                 205             


Gly Lys Ser Ser Phe Phe Asn Ser Val Lys Ser Ile Phe His Gly His 
    210                 215                 220                 


Val Thr Gly Gln Ala Val Val Gly Ser Asp Ile Thr Ser Ile Thr Glu 
225                 230                 235                 240 


Arg Tyr Arg Ile Tyr Ser Val Lys Asp Gly Lys Asn Gly Lys Ser Leu 
                245                 250                 255     


Pro Phe Met Leu Cys Asp Thr Met Gly Leu Asp Gly Ala Glu Gly Ala 
            260                 265                 270         


Gly Leu Cys Met Asp Asp Ile Pro His Ile Leu Lys Gly Cys Met Pro 
        275                 280                 285             


Asp Arg Tyr Gln Phe Asn Ser Arg Lys Pro Ile Thr Pro Glu His Ser 
    290                 295                 300                 


Thr Phe Ile Thr Ser Pro Ser Leu Lys Asp Arg Ile His Cys Val Ala 
305                 310                 315                 320 


Tyr Val Leu Asp Ile Asn Ser Ile Asp Asn Leu Tyr Ser Lys Met Leu 
                325                 330                 335     


Ala Lys Val Lys Gln Val His Lys Glu Val Leu Asn Cys Gly Ile Ala 
            340                 345                 350         


Tyr Val Ala Leu Leu Thr Lys Val Asp Asp Cys Ser Glu Val Leu Gln 
        355                 360                 365             


Asp Asn Phe Leu Asn Met Ser Arg Ser Met Thr Ser Gln Ser Arg Val 
    370                 375                 380                 


Met Asn Val His Lys Met Leu Gly Ile Pro Ile Ser Asn Ile Leu Met 
385                 390                 395                 400 


Val Gly Asn Tyr Ala Ser Asp Leu Glu Leu Asp Pro Met Lys Asp Ile 
                405                 410                 415     


Leu Ile Leu Ser Ala Leu Arg Gln Met Leu Arg Ala Ala Asp Asp Phe 
            420                 425                 430         


Leu Glu Asp Leu Pro Leu Glu Glu Thr Gly Ala Ile Glu Arg Ala Leu 
        435                 440                 445             


Gln Pro Cys Ile 
    450         


<210> 6
<211> 361
<212> PRT
<213> Homo sapiens

<400> 6
Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210> 7
<211> 130
<212> PRT
<213> Homo sapiens

<400> 7
Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Lys Lys Lys Cys Ser Glu Ser Ser 
            20                  25                  30          


Asp Ser Gly Ser Gly Phe Trp Lys Ala Leu Thr Phe Met Ala Val Gly 
        35                  40                  45              


Gly Gly Leu Ala Val Ala Gly Leu Pro Ala Leu Gly Phe Thr Gly Ala 
    50                  55                  60                  


Gly Ile Ala Ala Asn Ser Val Ala Ala Ser Leu Met Ser Trp Ser Ala 
65                  70                  75                  80  


Ile Leu Asn Gly Gly Gly Val Pro Ala Gly Gly Leu Val Ala Thr Leu 
                85                  90                  95      


Gln Ser Leu Gly Ala Gly Gly Ser Ser Val Val Ile Gly Asn Ile Gly 
            100                 105                 110         


Ala Leu Met Gly Tyr Ala Thr His Lys Tyr Leu Asp Ser Glu Glu Asp 
        115                 120                 125             


Glu Glu 
    130 


<210> 8
<211> 662
<212> PRT
<213> Homo sapiens

<400> 8
Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210> 9
<211> 478
<212> PRT
<213> Homo sapiens

<400> 9
Met Ser Thr Asn Gly Asp Asp His Gln Val Lys Asp Ser Leu Glu Gln 
1               5                   10                  15      


Leu Arg Cys His Phe Thr Trp Glu Leu Ser Ile Asp Asp Asp Glu Met 
            20                  25                  30          


Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp Thr 
        35                  40                  45              


Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His Leu 
    50                  55                  60                  


Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu Asn 
65                  70                  75                  80  


Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu Val 
                85                  90                  95      


Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu Ala 
            100                 105                 110         


Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys Leu 
        115                 120                 125             


Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys Glu 
    130                 135                 140                 


Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala 
145                 150                 155                 160 


Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro Glu 
                165                 170                 175     


Ser Ser Ala Gly Tyr Ala Ile Ser Ala Tyr Arg Leu Asp Gly Phe Lys 
            180                 185                 190         


Leu Ala Thr Lys Asn His Lys Pro Phe Ser Leu Leu Pro Leu Arg Gln 
        195                 200                 205             


Ala Val Arg Leu Asn Pro Asp Asn Gly Tyr Ile Lys Val Leu Leu Ala 
    210                 215                 220                 


Leu Lys Leu Gln Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Glu Glu Ala Leu Ala Asn Met Ser Ser Gln Thr Tyr Val Phe Arg Tyr 
                245                 250                 255     


Ala Ala Lys Phe Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu Glu 
            260                 265                 270         


Leu Leu Lys Lys Ala Leu Gln Glu Thr Pro Thr Ser Val Leu Leu His 
        275                 280                 285             


His Gln Ile Gly Leu Cys Tyr Lys Ala Gln Met Ile Gln Ile Lys Glu 
    290                 295                 300                 


Ala Thr Lys Gly Gln Pro Arg Gly Gln Asn Arg Glu Lys Leu Asp Lys 
305                 310                 315                 320 


Met Ile Arg Ser Ala Ile Phe His Phe Glu Ser Ala Val Glu Lys Lys 
                325                 330                 335     


Pro Thr Phe Glu Val Ala His Leu Asp Leu Ala Arg Met Tyr Ile Glu 
            340                 345                 350         


Ala Gly Asn His Arg Lys Ala Glu Glu Asn Phe Gln Lys Leu Leu Cys 
        355                 360                 365             


Met Lys Pro Val Val Glu Glu Thr Met Gln Asp Ile His Phe His Tyr 
    370                 375                 380                 


Gly Arg Phe Gln Glu Phe Gln Lys Lys Ser Asp Val Asn Ala Ile Ile 
385                 390                 395                 400 


His Tyr Leu Lys Ala Ile Lys Ile Glu Gln Ala Ser Leu Thr Arg Asp 
                405                 410                 415     


Lys Ser Ile Asn Ser Leu Lys Lys Leu Val Leu Arg Lys Leu Arg Arg 
            420                 425                 430         


Lys Ala Leu Asp Leu Glu Ser Leu Ser Leu Leu Gly Phe Val Tyr Lys 
        435                 440                 445             


Leu Glu Gly Asn Met Asn Glu Ala Leu Glu Tyr Tyr Glu Arg Ala Leu 
    450                 455                 460                 


Arg Leu Ala Ala Asp Phe Glu Asn Ser Val Arg Gln Gly Pro 
465                 470                 475             


<210> 10
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Arg Arg Ser Arg Arg Lys Ser Arg Arg Asn Gly Arg Ser Thr 
1               5                   10                  15      


Ala Gly Lys Ala Ala Ala Thr Gln Pro Ala Lys Ser Pro Gly Ala Gln 
            20                  25                  30          


Leu Trp Leu Phe Pro Ser Ala Ala Gly Leu His Arg Ala Leu Leu Arg 
        35                  40                  45              


Arg Val Glu Val Thr Arg Gln Leu Cys Cys Ser Pro Gly Arg Leu Ala 
    50                  55                  60                  


Val Leu Glu Arg Gly Gly Ala Gly Val Gln Val His Gln Leu Leu Ala 
65                  70                  75                  80  


Gly Ser Gly Gly Ala Arg Thr Pro Lys Cys Ile Lys Leu Gly Lys Asn 
                85                  90                  95      


Met Lys Ile His Ser Val Asp Gln Gly Ala Glu His Met Leu Ile Leu 
            100                 105                 110         


Ser Ser Asp Gly Lys Pro Phe Glu Tyr Asp Asn Tyr Ser Met Lys His 
        115                 120                 125             


Leu Arg Phe Glu Ser Ile Leu Gln Glu Lys Lys Ile Ile Gln Ile Thr 
    130                 135                 140                 


Cys Gly Asp Tyr His Ser Leu Ala Leu Ser Lys Gly Gly Glu Leu Phe 
145                 150                 155                 160 


Ala Trp Gly Gln Asn Leu His Gly Gln Leu Gly Val Gly Arg Lys Phe 
                165                 170                 175     


Pro Ser Thr Thr Thr Pro Gln Ile Val Glu His Leu Ala Gly Val Pro 
            180                 185                 190         


Leu Ala Gln Ile Ser Ala Gly Glu Ala His Ser Met Ala Leu Ser Met 
        195                 200                 205             


Ser Gly Asn Ile Tyr Ser Trp Gly Lys Asn Glu Cys Gly Gln Leu Gly 
    210                 215                 220                 


Leu Gly His Thr Glu Ser Lys Asp Asp Pro Ser Leu Ile Glu Gly Leu 
225                 230                 235                 240 


Asp Asn Gln Lys Val Glu Phe Val Ala Cys Gly Gly Ser His Ser Ala 
                245                 250                 255     


Leu Leu Thr Gln Asp Gly Leu Leu Phe Thr Phe Gly Ala Gly Lys His 
            260                 265                 270         


Gly Gln Leu Gly His Asn Ser Thr Gln Asn Glu Leu Arg Pro Cys Leu 
        275                 280                 285             


Val Ala Glu Leu Val Gly Tyr Arg Val Thr Gln Ile Ala Cys Gly Arg 
    290                 295                 300                 


Trp His Thr Leu Ala Tyr Val Ser Asp Leu Gly Lys Val Phe Ser Phe 
305                 310                 315                 320 


Gly Ser Gly Lys Asp Gly Gln Leu Gly Asn Gly Gly Thr Arg Asp Gln 
                325                 330                 335     


Leu Met Pro Leu Pro Val Lys Val Ser Ser Ser Glu Glu Leu Lys Leu 
            340                 345                 350         


Glu Ser His Thr Ser Glu Lys Glu Leu Ile Met Ile Ala Gly Gly Asn 
        355                 360                 365             


Gln Ser Ile Leu Leu Trp Ile Lys Lys Glu Asn Ser Tyr Val Asn Leu 
    370                 375                 380                 


Lys Arg Thr Ile Pro Thr Leu Asn Glu Gly Thr Val Lys Arg Trp Ile 
385                 390                 395                 400 


Ala Asp Val Glu Thr Lys Arg Trp Gln Ser Thr Lys Arg Glu Ile Gln 
                405                 410                 415     


Glu Ile Phe Ser Ser Pro Ala Cys Leu Thr Gly Ser Phe Leu Arg Lys 
            420                 425                 430         


Arg Arg Thr Thr Glu Met Met Pro Val Tyr Leu Asp Leu Asn Lys Ala 
        435                 440                 445             


Arg Asn Ile Phe Lys Glu Leu Thr Gln Lys Asp Trp Ile Thr Asn Met 
    450                 455                 460                 


Ile Thr Thr Cys Leu Lys Asp Asn Leu Leu Lys Arg Leu Pro Phe His 
465                 470                 475                 480 


Ser Pro Pro Gln Glu Ala Leu Glu Ile Phe Phe Leu Leu Pro Glu Cys 
                485                 490                 495     


Pro Met Met His Ile Ser Asn Asn Trp Glu Ser Leu Val Val Pro Phe 
            500                 505                 510         


Ala Lys Val Val Cys Lys Met Ser Asp Gln Ser Ser Leu Val Leu Glu 
        515                 520                 525             


Glu Tyr Trp Ala Thr Leu Gln Glu Ser Thr Phe Ser Lys Leu Val Gln 
    530                 535                 540                 


Met Phe Lys Thr Ala Val Ile Cys Gln Leu Asp Tyr Trp Asp Glu Ser 
545                 550                 555                 560 


Ala Glu Glu Asn Gly Asn Val Gln Ala Leu Leu Glu Met Leu Lys Lys 
                565                 570                 575     


Leu His Arg Val Asn Gln Val Lys Cys Gln Leu Pro Glu Ser Ile Phe 
            580                 585                 590         


Gln Val Asp Glu Leu Leu His Arg Leu Asn Phe Phe Val Glu Val Cys 
        595                 600                 605             


Arg Arg Tyr Leu Trp Lys Met Thr Val Asp Ala Ser Glu Asn Val Gln 
    610                 615                 620                 


Cys Cys Val Ile Phe Ser His Phe Pro Phe Ile Phe Asn Asn Leu Ser 
625                 630                 635                 640 


Lys Ile Lys Leu Leu His Thr Asp Thr Leu Leu Lys Ile Glu Ser Lys 
                645                 650                 655     


Lys His Lys Ala Tyr Leu Arg Ser Ala Ala Ile Glu Glu Glu Arg Glu 
            660                 665                 670         


Ser Glu Phe Ala Leu Arg Pro Thr Phe Asp Leu Thr Val Arg Arg Asn 
        675                 680                 685             


His Leu Ile Glu Asp Val Leu Asn Gln Leu Ser Gln Phe Glu Asn Glu 
    690                 695                 700                 


Asp Leu Arg Lys Glu Leu Trp Val Ser Phe Ser Gly Glu Ile Gly Tyr 
705                 710                 715                 720 


Asp Leu Gly Gly Val Lys Lys Glu Phe Phe Tyr Cys Leu Phe Ala Glu 
                725                 730                 735     


Met Ile Gln Pro Glu Tyr Gly Met Phe Met Tyr Pro Glu Gly Ala Ser 
            740                 745                 750         


Cys Met Trp Phe Pro Val Lys Pro Lys Phe Glu Lys Lys Arg Tyr Phe 
        755                 760                 765             


Phe Phe Gly Val Leu Cys Gly Leu Ser Leu Phe Asn Cys Asn Val Ala 
    770                 775                 780                 


Asn Leu Pro Phe Pro Leu Ala Leu Phe Lys Lys Leu Leu Asp Gln Met 
785                 790                 795                 800 


Pro Ser Leu Glu Asp Leu Lys Glu Leu Ser Pro Asp Leu Gly Lys Asn 
                805                 810                 815     


Leu Gln Thr Leu Leu Asp Asp Glu Gly Asp Asn Phe Glu Glu Val Phe 
            820                 825                 830         


Tyr Ile His Phe Asn Val His Trp Asp Arg Asn Asp Thr Asn Leu Ile 
        835                 840                 845             


Pro Asn Gly Ser Ser Ile Thr Val Asn Gln Thr Asn Lys Arg Asp Tyr 
    850                 855                 860                 


Val Ser Lys Tyr Ile Asn Tyr Ile Phe Asn Asp Ser Val Lys Ala Val 
865                 870                 875                 880 


Tyr Glu Glu Phe Arg Arg Gly Phe Tyr Lys Met Cys Asp Glu Asp Ile 
                885                 890                 895     


Ile Lys Leu Phe His Pro Glu Glu Leu Lys Asp Val Ile Val Gly Asn 
            900                 905                 910         


Thr Asp Tyr Asp Trp Lys Thr Phe Glu Lys Asn Ala Arg Tyr Glu Pro 
        915                 920                 925             


Gly Tyr Asn Ser Ser His Pro Thr Ile Val Met Phe Trp Lys Ala Phe 
    930                 935                 940                 


His Lys Leu Thr Leu Glu Glu Lys Lys Lys Phe Leu Val Phe Leu Thr 
945                 950                 955                 960 


Gly Thr Asp Arg Leu Gln Met Lys Asp Leu Asn Asn Met Lys Ile Thr 
                965                 970                 975     


Phe Cys Cys Pro Glu Ser Trp Asn Glu Arg Asp Pro Ile Arg Ala Leu 
            980                 985                 990         


Thr Cys Phe Ser Val Leu Phe Leu  Pro Lys Tyr Ser Thr  Met Glu Thr 
        995                 1000                 1005             


Val Glu  Glu Ala Leu Gln Glu  Ala Ile Asn Asn Asn  Arg Gly Phe 
    1010                 1015                 1020             


Gly 
    


<210> 11
<211> 165
<212> PRT
<213> Homo sapiens

<400> 11
Met Gly Trp Asp Leu Thr Val Lys Met Leu Ala Gly Asn Glu Phe Gln 
1               5                   10                  15      


Val Ser Leu Ser Ser Ser Met Ser Val Ser Glu Leu Lys Ala Gln Ile 
            20                  25                  30          


Thr Gln Lys Ile Gly Val His Ala Phe Gln Gln Arg Leu Ala Val His 
        35                  40                  45              


Pro Ser Gly Val Ala Leu Gln Asp Arg Val Pro Leu Ala Ser Gln Gly 
    50                  55                  60                  


Leu Gly Pro Gly Ser Thr Val Leu Leu Val Val Asp Lys Cys Asp Glu 
65                  70                  75                  80  


Pro Leu Ser Ile Leu Val Arg Asn Asn Lys Gly Arg Ser Ser Thr Tyr 
                85                  90                  95      


Glu Val Arg Leu Thr Gln Thr Val Ala His Leu Lys Gln Gln Val Ser 
            100                 105                 110         


Gly Leu Glu Gly Val Gln Asp Asp Leu Phe Trp Leu Thr Phe Glu Gly 
        115                 120                 125             


Lys Pro Leu Glu Asp Gln Leu Pro Leu Gly Glu Tyr Gly Leu Lys Pro 
    130                 135                 140                 


Leu Ser Thr Val Phe Met Asn Leu Arg Leu Arg Gly Gly Gly Thr Glu 
145                 150                 155                 160 


Pro Gly Gly Arg Ser 
                165 


<210> 12
<211> 416
<212> PRT
<213> Homo sapiens

<400> 12
Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210> 13
<211> 1087
<212> PRT
<213> Homo sapiens

<400> 13
Met Asp Leu Tyr Ser Thr Pro Ala Ala Ala Leu Asp Arg Phe Val Ala 
1               5                   10                  15      


Arg Arg Leu Gln Pro Arg Lys Glu Phe Val Glu Lys Ala Arg Arg Ala 
            20                  25                  30          


Leu Gly Ala Leu Ala Ala Ala Leu Arg Glu Arg Gly Gly Arg Leu Gly 
        35                  40                  45              


Ala Ala Ala Pro Arg Val Leu Lys Thr Val Lys Gly Gly Ser Ser Gly 
    50                  55                  60                  


Arg Gly Thr Ala Leu Lys Gly Gly Cys Asp Ser Glu Leu Val Ile Phe 
65                  70                  75                  80  


Leu Asp Cys Phe Lys Ser Tyr Val Asp Gln Arg Ala Arg Arg Ala Glu 
                85                  90                  95      


Ile Leu Ser Glu Met Arg Ala Ser Leu Glu Ser Trp Trp Gln Asn Pro 
            100                 105                 110         


Val Pro Gly Leu Arg Leu Thr Phe Pro Glu Gln Ser Val Pro Gly Ala 
        115                 120                 125             


Leu Gln Phe Arg Leu Thr Ser Val Asp Leu Glu Asp Trp Met Asp Val 
    130                 135                 140                 


Ser Leu Val Pro Ala Phe Asn Val Leu Gly Gln Ala Gly Ser Gly Val 
145                 150                 155                 160 


Lys Pro Lys Pro Gln Val Tyr Ser Thr Leu Leu Asn Ser Gly Cys Gln 
                165                 170                 175     


Gly Gly Glu His Ala Ala Cys Phe Thr Glu Leu Arg Arg Asn Phe Val 
            180                 185                 190         


Asn Ile Arg Pro Ala Lys Leu Lys Asn Leu Ile Leu Leu Val Lys His 
        195                 200                 205             


Trp Tyr His Gln Val Cys Leu Gln Gly Leu Trp Lys Glu Thr Leu Pro 
    210                 215                 220                 


Pro Val Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala Trp Glu Gln Gly 
225                 230                 235                 240 


Cys Lys Lys Asp Ala Phe Ser Leu Ala Glu Gly Leu Arg Thr Val Leu 
                245                 250                 255     


Gly Leu Ile Gln Gln His Gln His Leu Cys Val Phe Trp Thr Val Asn 
            260                 265                 270         


Tyr Gly Phe Glu Asp Pro Ala Val Gly Gln Phe Leu Gln Arg Gln Leu 
        275                 280                 285             


Lys Arg Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro Thr Trp Asp 
    290                 295                 300                 


Leu Gly Asn Gly Ala Ala Trp His Trp Asp Leu Leu Ala Gln Glu Ala 
305                 310                 315                 320 


Ala Ser Cys Tyr Asp His Pro Cys Phe Leu Arg Gly Met Gly Asp Pro 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Pro Gly Leu Pro Arg Ala Gly Cys Ser Gly 
            340                 345                 350         


Leu Gly His Pro Ile Gln Leu Asp Pro Asn Gln Lys Thr Pro Glu Asn 
        355                 360                 365             


Ser Lys Ser Leu Asn Ala Val Tyr Pro Arg Ala Gly Ser Lys Pro Pro 
    370                 375                 380                 


Ser Cys Pro Ala Pro Gly Pro Thr Gly Ala Ala Ser Ile Val Pro Ser 
385                 390                 395                 400 


Val Pro Gly Met Ala Leu Asp Leu Ser Gln Ile Pro Thr Lys Glu Leu 
                405                 410                 415     


Asp Arg Phe Ile Gln Asp His Leu Lys Pro Ser Pro Gln Phe Gln Glu 
            420                 425                 430         


Gln Val Lys Lys Ala Ile Asp Ile Ile Leu Arg Cys Leu His Glu Asn 
        435                 440                 445             


Cys Val His Lys Ala Ser Arg Val Ser Lys Gly Gly Ser Phe Gly Arg 
    450                 455                 460                 


Gly Thr Asp Leu Arg Asp Gly Cys Asp Val Glu Leu Ile Ile Phe Leu 
465                 470                 475                 480 


Asn Cys Phe Thr Asp Tyr Lys Asp Gln Gly Pro Arg Arg Ala Glu Ile 
                485                 490                 495     


Leu Asp Glu Met Arg Ala Gln Leu Glu Ser Trp Trp Gln Asp Gln Val 
            500                 505                 510         


Pro Ser Leu Ser Leu Gln Phe Pro Glu Gln Asn Val Pro Glu Ala Leu 
        515                 520                 525             


Gln Phe Gln Leu Val Ser Thr Ala Leu Lys Ser Trp Thr Asp Val Ser 
    530                 535                 540                 


Leu Leu Pro Ala Phe Asp Ala Val Gly Gln Leu Ser Ser Gly Thr Lys 
545                 550                 555                 560 


Pro Asn Pro Gln Val Tyr Ser Arg Leu Leu Thr Ser Gly Cys Gln Glu 
                565                 570                 575     


Gly Glu His Lys Ala Cys Phe Ala Glu Leu Arg Arg Asn Phe Met Asn 
            580                 585                 590         


Ile Arg Pro Val Lys Leu Lys Asn Leu Ile Leu Leu Val Lys His Trp 
        595                 600                 605             


Tyr Arg Gln Val Ala Ala Gln Asn Lys Gly Lys Gly Pro Ala Pro Ala 
    610                 615                 620                 


Ser Leu Pro Pro Ala Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala Trp 
625                 630                 635                 640 


Glu Gln Gly Cys Arg Gln Asp Cys Phe Asn Met Ala Gln Gly Phe Arg 
                645                 650                 655     


Thr Val Leu Gly Leu Val Gln Gln His Gln Gln Leu Cys Val Tyr Trp 
            660                 665                 670         


Thr Val Asn Tyr Ser Thr Glu Asp Pro Ala Met Arg Met His Leu Leu 
        675                 680                 685             


Gly Gln Leu Arg Lys Pro Arg Pro Leu Val Leu Asp Pro Ala Asp Pro 
    690                 695                 700                 


Thr Trp Asn Val Gly His Gly Ser Trp Glu Leu Leu Ala Gln Glu Ala 
705                 710                 715                 720 


Ala Ala Leu Gly Met Gln Ala Cys Phe Leu Ser Arg Asp Gly Thr Ser 
                725                 730                 735     


Val Gln Pro Trp Asp Val Met Pro Ala Leu Leu Tyr Gln Thr Pro Ala 
            740                 745                 750         


Gly Asp Leu Asp Lys Phe Ile Ser Glu Phe Leu Gln Pro Asn Arg Gln 
        755                 760                 765             


Phe Leu Ala Gln Val Asn Lys Ala Val Asp Thr Ile Cys Ser Phe Leu 
    770                 775                 780                 


Lys Glu Asn Cys Phe Arg Asn Ser Pro Ile Lys Val Ile Lys Val Val 
785                 790                 795                 800 


Lys Gly Gly Ser Ser Ala Lys Gly Thr Ala Leu Arg Gly Arg Ser Asp 
                805                 810                 815     


Ala Asp Leu Val Val Phe Leu Ser Cys Phe Ser Gln Phe Thr Glu Gln 
            820                 825                 830         


Gly Asn Lys Arg Ala Glu Ile Ile Ser Glu Ile Arg Ala Gln Leu Glu 
        835                 840                 845             


Ala Cys Gln Gln Glu Arg Gln Phe Glu Val Lys Phe Glu Val Ser Lys 
    850                 855                 860                 


Trp Glu Asn Pro Arg Val Leu Ser Phe Ser Leu Thr Ser Gln Thr Met 
865                 870                 875                 880 


Leu Asp Gln Ser Val Asp Phe Asp Val Leu Pro Ala Phe Asp Ala Leu 
                885                 890                 895     


Gly Gln Leu Val Ser Gly Ser Arg Pro Ser Ser Gln Val Tyr Val Asp 
            900                 905                 910         


Leu Ile His Ser Tyr Ser Asn Ala Gly Glu Tyr Ser Thr Cys Phe Thr 
        915                 920                 925             


Glu Leu Gln Arg Asp Phe Ile Ile Ser Arg Pro Thr Lys Leu Lys Ser 
    930                 935                 940                 


Leu Ile Arg Leu Val Lys His Trp Tyr Gln Gln Cys Thr Lys Ile Ser 
945                 950                 955                 960 


Lys Gly Arg Gly Ser Leu Pro Pro Gln His Gly Leu Glu Leu Leu Thr 
                965                 970                 975     


Val Tyr Ala Trp Glu Gln Gly Gly Lys Asp Ser Gln Phe Asn Met Ala 
            980                 985                 990         


Glu Gly Phe Arg Thr Val Leu Glu  Leu Val Thr Gln Tyr  Arg Gln Leu 
        995                 1000                 1005             


Cys Ile  Tyr Trp Thr Ile Asn  Tyr Asn Ala Lys Asp  Lys Thr Val 
    1010                 1015                 1020             


Gly Asp  Phe Leu Lys Gln Gln  Leu Gln Lys Pro Arg  Pro Ile Ile 
    1025                 1030                 1035             


Leu Asp  Pro Ala Asp Pro Thr  Gly Asn Leu Gly His  Asn Ala Arg 
    1040                 1045                 1050             


Trp Asp  Leu Leu Ala Lys Glu  Ala Ala Ala Cys Thr  Ser Ala Leu 
    1055                 1060                 1065             


Cys Cys  Met Gly Arg Asn Gly  Ile Pro Ile Gln Pro  Trp Pro Val 
    1070                 1075                 1080             


Lys Ala  Ala Val 
    1085         


<210> 14
<211> 400
<212> PRT
<213> Homo sapiens

<400> 14
Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Ala Glu Ser Asn Ser Ala 
            340                 345                 350         


Asp Asp Glu Thr Asp Asp Pro Arg Arg Tyr Gln Lys Tyr Gly Tyr Ile 
        355                 360                 365             


Gly Thr His Glu Tyr Pro His Phe Ser His Arg Pro Ser Thr Leu Gln 
    370                 375                 380                 


Ala Ala Ser Thr Pro Gln Ala Glu Glu Asp Trp Thr Cys Thr Ile Leu 
385                 390                 395                 400 


<210> 15
<211> 410
<212> PRT
<213> Homo sapiens

<400> 15
Met Asn Thr Arg Asn Arg Val Val Asn Ser Gly Leu Gly Ala Ser Pro 
1               5                   10                  15      


Ala Ser Arg Pro Thr Arg Asp Pro Gln Asp Pro Ser Gly Arg Gln Gly 
            20                  25                  30          


Glu Leu Ser Pro Val Glu Asp Gln Arg Glu Gly Leu Glu Ala Ala Pro 
        35                  40                  45              


Lys Gly Pro Ser Arg Glu Ser Val Val His Ala Gly Gln Arg Arg Thr 
    50                  55                  60                  


Ser Ala Tyr Thr Leu Ile Ala Pro Asn Ile Asn Arg Arg Asn Glu Ile 
65                  70                  75                  80  


Gln Arg Ile Ala Glu Gln Glu Leu Ala Asn Leu Glu Lys Trp Lys Glu 
                85                  90                  95      


Gln Asn Arg Ala Lys Pro Val His Leu Val Pro Arg Arg Leu Gly Gly 
            100                 105                 110         


Ser Gln Ser Glu Thr Glu Val Arg Gln Lys Gln Gln Leu Gln Leu Met 
        115                 120                 125             


Gln Ser Lys Tyr Lys Gln Lys Leu Lys Arg Glu Glu Ser Val Arg Ile 
    130                 135                 140                 


Lys Lys Glu Ala Glu Glu Ala Glu Leu Gln Lys Met Lys Ala Ile Gln 
145                 150                 155                 160 


Arg Glu Lys Ser Asn Lys Leu Glu Glu Lys Lys Arg Leu Gln Glu Asn 
                165                 170                 175     


Leu Arg Arg Glu Ala Phe Arg Glu His Gln Gln Tyr Lys Thr Ala Glu 
            180                 185                 190         


Phe Leu Ser Lys Leu Asn Thr Glu Ser Pro Asp Arg Ser Ala Cys Gln 
        195                 200                 205             


Ser Ala Val Cys Gly Pro Gln Ser Ser Thr Trp Lys Leu Pro Ile Leu 
    210                 215                 220                 


Pro Arg Asp His Ser Trp Ala Arg Ser Trp Ala Tyr Arg Asp Ser Leu 
225                 230                 235                 240 


Lys Ala Glu Glu Asn Arg Lys Leu Gln Lys Met Lys Asp Glu Gln His 
                245                 250                 255     


Gln Lys Ser Glu Leu Leu Glu Leu Lys Arg Gln Gln Gln Glu Gln Glu 
            260                 265                 270         


Arg Ala Lys Ile His Gln Thr Glu His Arg Arg Val Asn Asn Ala Phe 
        275                 280                 285             


Leu Asp Arg Leu Gln Gly Lys Ser Gln Pro Gly Gly Leu Glu Gln Ser 
    290                 295                 300                 


Gly Gly Cys Trp Asn Met Asn Ser Gly Asn Ser Trp Gly Ser Leu Leu 
305                 310                 315                 320 


Val Phe Ser Arg His Leu Arg Val Tyr Glu Lys Ile Leu Thr Pro Ile 
                325                 330                 335     


Trp Pro Ser Ser Thr Asp Leu Glu Lys Pro His Glu Met Leu Phe Leu 
            340                 345                 350         


Asn Val Ile Leu Phe Ser Leu Thr Val Phe Thr Leu Ile Ser Thr Ala 
        355                 360                 365             


His Thr Leu Asp Arg Ala Val Arg Ser Asp Trp Leu Leu Leu Val Leu 
    370                 375                 380                 


Ile Tyr Ala Cys Leu Glu Glu Leu Ile Pro Glu Leu Ile Phe Asn Leu 
385                 390                 395                 400 


Tyr Cys Gln Gly Asn Ala Thr Leu Phe Phe 
                405                 410 


<210> 16
<211> 490
<212> PRT
<213> Homo sapiens

<400> 16
Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210> 17
<211> 86
<212> PRT
<213> Homo sapiens

<400> 17
Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Asn Leu Val Thr Phe Gly 
    50                  55                  60                  


His Ser Leu Ser Lys Thr Cys Ser Pro Ala Cys Pro Ile Pro Glu Gly 
65                  70                  75                  80  


Val Asn Val Ala Ala Ser 
                85      


<210> 18
<211> 172
<212> PRT
<213> Homo sapiens

<400> 18
Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Lys His Cys Trp Val Ser Gly Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Ser Gly Cys Gln Thr Ala Leu Cys Asn Leu 
                165                 170         


<210> 19
<211> 318
<212> PRT
<213> Homo sapiens

<400> 19
Met Asp Lys Gln Asn Ser Gln Met Asn Ala Ser His Pro Glu Thr Asn 
1               5                   10                  15      


Leu Pro Val Gly Tyr Pro Pro Gln Tyr Pro Pro Thr Ala Phe Gln Gly 
            20                  25                  30          


Pro Pro Gly Tyr Ser Gly Tyr Pro Gly Pro Gln Val Ser Tyr Pro Pro 
        35                  40                  45              


Pro Pro Ala Gly His Ser Gly Pro Gly Pro Ala Gly Phe Pro Val Pro 
    50                  55                  60                  


Asn Gln Pro Val Tyr Asn Gln Pro Val Tyr Asn Gln Pro Val Gly Ala 
65                  70                  75                  80  


Ala Gly Val Pro Trp Met Pro Ala Pro Gln Pro Pro Leu Asn Cys Pro 
                85                  90                  95      


Pro Gly Leu Glu Tyr Leu Ser Gln Ile Asp Gln Ile Leu Ile His Gln 
            100                 105                 110         


Gln Ile Glu Leu Leu Glu Val Leu Thr Gly Phe Glu Thr Asn Asn Lys 
        115                 120                 125             


Tyr Glu Ile Lys Asn Ser Phe Gly Gln Arg Val Tyr Phe Ala Ala Glu 
    130                 135                 140                 


Asp Thr Asp Cys Cys Thr Arg Asn Cys Cys Gly Pro Ser Arg Pro Phe 
145                 150                 155                 160 


Thr Leu Arg Ile Ile Asp Asn Met Gly Gln Glu Val Ile Thr Leu Glu 
                165                 170                 175     


Arg Pro Leu Arg Cys Ser Ser Cys Cys Cys Pro Cys Cys Leu Gln Glu 
            180                 185                 190         


Ile Glu Ile Gln Ala Pro Pro Gly Val Pro Ile Gly Tyr Val Ile Gln 
        195                 200                 205             


Thr Trp His Pro Cys Leu Pro Lys Phe Thr Ile Gln Asn Glu Lys Arg 
    210                 215                 220                 


Glu Asp Val Leu Lys Ile Ser Gly Pro Cys Val Val Cys Ser Cys Cys 
225                 230                 235                 240 


Gly Asp Val Asp Phe Glu Ile Lys Ser Leu Asp Glu Gln Cys Val Val 
                245                 250                 255     


Gly Lys Ile Ser Lys His Trp Thr Gly Ile Leu Arg Glu Ala Phe Thr 
            260                 265                 270         


Asp Ala Asp Asn Phe Gly Ile Gln Phe Pro Leu Asp Leu Asp Val Lys 
        275                 280                 285             


Met Lys Ala Val Met Ile Gly Ala Cys Phe Leu Ile Asp Phe Met Phe 
    290                 295                 300                 


Phe Glu Ser Thr Gly Ser Gln Glu Gln Lys Ser Gly Val Trp 
305                 310                 315             


<210> 20
<211> 1688
<212> PRT
<213> Homo sapiens

<400> 20
Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala 
1               5                   10                  15      


Gly Gln Ala Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val 
            20                  25                  30          


Lys Gly Ser Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp 
        35                  40                  45              


Val Glu Val Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser 
    50                  55                  60                  


Gly Gln Arg Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu 
65                  70                  75                  80  


Ala Arg Phe Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg 
                85                  90                  95      


Val Cys Asn Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser 
            100                 105                 110         


Tyr Asn Phe Arg Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val 
        115                 120                 125             


Lys Gly Thr Leu Val Thr Val Thr Glu Glu Pro Arg Val Pro Thr Ile 
    130                 135                 140                 


Ala Ser Pro Val Glu Leu Leu Glu Gly Thr Glu Val Asp Phe Asn Cys 
145                 150                 155                 160 


Ser Thr Pro Tyr Val Cys Leu Gln Glu Gln Val Arg Leu Gln Trp Gln 
                165                 170                 175     


Gly Gln Asp Pro Ala Arg Ser Val Thr Phe Asn Ser Gln Lys Phe Glu 
            180                 185                 190         


Pro Thr Gly Val Gly His Leu Glu Thr Leu His Met Ala Met Ser Trp 
        195                 200                 205             


Gln Asp His Gly Arg Ile Leu Arg Cys Gln Leu Ser Met Ala Asn His 
    210                 215                 220                 


Arg Ala Gln Ser Glu Ile His Leu Gln Val Lys Tyr Ala Pro Arg Gly 
225                 230                 235                 240 


Val Lys Ile Leu Leu Ser Pro Ser Gly Arg Asn Ile Leu Pro Gly Glu 
                245                 250                 255     


Leu Val Thr Leu Thr Cys Gln Val Asn Ser Ser Tyr Pro Ala Val Ser 
            260                 265                 270         


Ser Ile Lys Trp Leu Lys Asp Gly Val Arg Leu Gln Thr Lys Thr Gly 
        275                 280                 285             


Val Leu His Leu Pro Gln Ala Ala Trp Ser Asp Ala Gly Val Tyr Thr 
    290                 295                 300                 


Cys Gln Ala Glu Asn Gly Val Gly Ser Leu Val Ser Pro Pro Ile Ser 
305                 310                 315                 320 


Leu His Ile Phe Met Ala Glu Val Gln Val Ser Pro Ala Gly Pro Ile 
                325                 330                 335     


Leu Glu Asn Gln Thr Val Thr Leu Val Cys Asn Thr Pro Asn Glu Ala 
            340                 345                 350         


Pro Ser Asp Leu Arg Tyr Ser Trp Tyr Lys Asn His Val Leu Leu Glu 
        355                 360                 365             


Asp Ala His Ser His Thr Leu Arg Leu His Leu Ala Thr Arg Ala Asp 
    370                 375                 380                 


Thr Gly Phe Tyr Phe Cys Glu Val Gln Asn Val His Gly Ser Glu Arg 
385                 390                 395                 400 


Ser Gly Pro Val Ser Val Val Val Asn His Pro Pro Leu Thr Pro Val 
                405                 410                 415     


Leu Thr Ala Phe Leu Glu Thr Gln Ala Gly Leu Val Gly Ile Leu His 
            420                 425                 430         


Cys Ser Val Val Ser Glu Pro Leu Ala Thr Leu Val Leu Ser His Gly 
        435                 440                 445             


Gly His Ile Leu Ala Ser Thr Ser Gly Asp Ser Asp His Ser Pro Arg 
    450                 455                 460                 


Phe Ser Gly Thr Ser Gly Pro Asn Ser Leu Arg Leu Glu Ile Arg Asp 
465                 470                 475                 480 


Leu Glu Glu Thr Asp Ser Gly Glu Tyr Lys Cys Ser Ala Thr Asn Ser 
                485                 490                 495     


Leu Gly Asn Ala Thr Ser Thr Leu Asp Phe His Ala Asn Ala Ala Arg 
            500                 505                 510         


Leu Leu Ile Ser Pro Ala Ala Glu Val Val Glu Gly Gln Ala Val Thr 
        515                 520                 525             


Leu Ser Cys Arg Ser Gly Leu Ser Pro Thr Pro Asp Ala Arg Phe Ser 
    530                 535                 540                 


Trp Tyr Leu Asn Gly Ala Leu Leu His Glu Gly Pro Gly Ser Ser Leu 
545                 550                 555                 560 


Leu Leu Pro Ala Ala Ser Ser Thr Asp Ala Gly Ser Tyr His Cys Arg 
                565                 570                 575     


Ala Arg Asp Gly His Ser Ala Ser Gly Pro Ser Ser Pro Ala Val Leu 
            580                 585                 590         


Thr Val Leu Tyr Pro Pro Arg Gln Pro Thr Phe Thr Thr Arg Leu Asp 
        595                 600                 605             


Leu Asp Ala Ala Gly Ala Gly Ala Gly Arg Arg Gly Leu Leu Leu Cys 
    610                 615                 620                 


Arg Val Asp Ser Asp Pro Pro Ala Arg Leu Gln Leu Leu His Lys Asp 
625                 630                 635                 640 


Arg Val Val Ala Thr Ser Leu Pro Ser Gly Gly Gly Cys Ser Thr Cys 
                645                 650                 655     


Gly Gly Cys Ser Pro Arg Met Lys Val Thr Lys Ala Pro Asn Leu Leu 
            660                 665                 670         


Arg Val Glu Ile His Asn Pro Leu Leu Glu Glu Glu Gly Leu Tyr Leu 
        675                 680                 685             


Cys Glu Ala Ser Asn Ala Leu Gly Asn Ala Ser Thr Ser Ala Thr Phe 
    690                 695                 700                 


Asn Gly Gln Ala Thr Val Leu Ala Ile Ala Pro Ser His Thr Leu Gln 
705                 710                 715                 720 


Glu Gly Thr Glu Ala Asn Leu Thr Cys Asn Val Ser Arg Glu Ala Ala 
                725                 730                 735     


Gly Ser Pro Ala Asn Phe Ser Trp Phe Arg Asn Gly Val Leu Trp Ala 
            740                 745                 750         


Gln Gly Pro Leu Glu Thr Val Thr Leu Leu Pro Val Ala Arg Thr Asp 
        755                 760                 765             


Ala Ala Leu Tyr Ala Cys Arg Ile Leu Thr Glu Ala Gly Ala Gln Leu 
    770                 775                 780                 


Ser Thr Pro Val Leu Leu Ser Val Leu Tyr Pro Pro Asp Arg Pro Lys 
785                 790                 795                 800 


Leu Ser Ala Leu Leu Asp Met Gly Gln Gly His Met Ala Leu Phe Ile 
                805                 810                 815     


Cys Thr Val Asp Ser Arg Pro Leu Ala Leu Leu Ala Leu Phe His Gly 
            820                 825                 830         


Glu His Leu Leu Ala Thr Ser Leu Gly Pro Gln Val Pro Ser His Gly 
        835                 840                 845             


Arg Phe Gln Ala Lys Ala Glu Ala Asn Ser Leu Lys Leu Glu Val Arg 
    850                 855                 860                 


Glu Leu Gly Leu Gly Asp Ser Gly Ser Tyr Arg Cys Glu Ala Thr Asn 
865                 870                 875                 880 


Val Leu Gly Ser Ser Asn Thr Ser Leu Phe Phe Gln Val Arg Gly Ala 
                885                 890                 895     


Trp Val Gln Val Ser Pro Ser Pro Glu Leu Gln Glu Gly Gln Ala Val 
            900                 905                 910         


Val Leu Ser Cys Gln Val Pro Thr Gly Val Pro Glu Gly Thr Ser Tyr 
        915                 920                 925             


Arg Trp Tyr Arg Asp Gly Gln Pro Leu Gln Glu Ser Thr Ser Ala Thr 
    930                 935                 940                 


Leu Arg Phe Ala Ala Ile Thr Leu Thr Gln Ala Gly Ala Tyr His Cys 
945                 950                 955                 960 


Gln Ala Gln Ala Pro Gly Ser Ala Thr Thr Ser Leu Ala Val Pro Ile 
                965                 970                 975     


Ser Leu His Val Ser Tyr Ala Pro Arg His Val Thr Leu Thr Thr Leu 
            980                 985                 990         


Met Asp Thr Gly Pro Gly Arg Leu  Gly Leu Leu Leu Cys  Arg Val Asp 
        995                 1000                 1005             


Ser Asp  Pro Pro Ala Gln Leu  Arg Leu Leu His Gly  Asp Arg Leu 
    1010                 1015                 1020             


Val Ala  Ser Thr Leu Gln Gly  Val Gly Gly Pro Glu  Gly Ser Ser 
    1025                 1030                 1035             


Pro Arg  Leu His Val Ala Val  Ala Pro Asn Thr Leu  Arg Leu Glu 
    1040                 1045                 1050             


Ile His  Gly Ala Met Leu Glu  Asp Glu Gly Val Tyr  Ile Cys Glu 
    1055                 1060                 1065             


Ala Ser  Asn Thr Leu Gly Gln  Ala Ser Ala Ser Ala  Asp Phe Asp 
    1070                 1075                 1080             


Ala Gln  Ala Val Asn Val Gln  Val Trp Pro Gly Ala  Thr Val Arg 
    1085                 1090                 1095             


Glu Gly  Gln Leu Val Asn Leu  Thr Cys Leu Val Trp  Thr Thr His 
    1100                 1105                 1110             


Pro Ala  Gln Leu Thr Tyr Thr  Trp Tyr Gln Asp Gly  Gln Gln Arg 
    1115                 1120                 1125             


Leu Asp  Ala His Ser Ile Pro  Leu Pro Asn Val Thr  Val Arg Asp 
    1130                 1135                 1140             


Ala Thr  Ser Tyr Arg Cys Gly  Val Gly Pro Pro Gly  Arg Ala Pro 
    1145                 1150                 1155             


Arg Leu  Ser Arg Pro Ile Thr  Leu Asp Val Leu Tyr  Ala Pro Arg 
    1160                 1165                 1170             


Asn Leu  Arg Leu Thr Tyr Leu  Leu Glu Ser His Gly  Gly Gln Leu 
    1175                 1180                 1185             


Ala Leu  Val Leu Cys Thr Val  Asp Ser Arg Pro Pro  Ala Gln Leu 
    1190                 1195                 1200             


Ala Leu  Ser His Ala Gly Arg  Leu Leu Ala Ser Ser  Thr Ala Ala 
    1205                 1210                 1215             


Ser Val  Pro Asn Thr Leu Arg  Leu Glu Leu Arg Gly  Pro Gln Pro 
    1220                 1225                 1230             


Arg Asp  Glu Gly Phe Tyr Ser  Cys Ser Ala Arg Ser  Pro Leu Gly 
    1235                 1240                 1245             


Gln Ala  Asn Thr Ser Leu Glu  Leu Arg Leu Glu Gly  Val Arg Val 
    1250                 1255                 1260             


Ile Leu  Ala Pro Glu Ala Ala  Val Pro Glu Gly Ala  Pro Ile Thr 
    1265                 1270                 1275             


Val Thr  Cys Ala Asp Pro Ala  Ala His Ala Pro Thr  Leu Tyr Thr 
    1280                 1285                 1290             


Trp Tyr  His Asn Gly Arg Trp  Leu Gln Glu Gly Pro  Ala Ala Ser 
    1295                 1300                 1305             


Leu Ser  Phe Leu Val Ala Thr  Arg Ala His Ala Gly  Ala Tyr Ser 
    1310                 1315                 1320             


Cys Gln  Ala Gln Asp Ala Gln  Gly Thr Arg Ser Ser  Arg Pro Ala 
    1325                 1330                 1335             


Ala Leu  Gln Val Leu Tyr Ala  Pro Gln Asp Ala Val  Leu Ser Ser 
    1340                 1345                 1350             


Phe Arg  Asp Ser Arg Ala Arg  Ser Met Ala Val Ile  Gln Cys Thr 
    1355                 1360                 1365             


Val Asp  Ser Glu Pro Pro Ala  Glu Leu Ala Leu Ser  His Asp Gly 
    1370                 1375                 1380             


Lys Val  Leu Ala Thr Ser Ser  Gly Val His Ser Leu  Ala Ser Gly 
    1385                 1390                 1395             


Thr Gly  His Val Gln Val Ala  Arg Asn Ala Leu Arg  Leu Gln Val 
    1400                 1405                 1410             


Gln Asp  Val Pro Ala Gly Asp  Asp Thr Tyr Val Cys  Thr Ala Gln 
    1415                 1420                 1425             


Asn Leu  Leu Gly Ser Ile Ser  Thr Ile Gly Arg Leu  Gln Val Glu 
    1430                 1435                 1440             


Gly Ala  Arg Val Val Ala Glu  Pro Gly Leu Asp Val  Pro Glu Gly 
    1445                 1450                 1455             


Ala Ala  Leu Asn Leu Ser Cys  Arg Leu Leu Gly Gly  Pro Gly Pro 
    1460                 1465                 1470             


Val Gly  Asn Ser Thr Phe Ala  Trp Phe Trp Asn Asp  Arg Arg Leu 
    1475                 1480                 1485             


His Ala  Glu Pro Val Pro Thr  Leu Ala Phe Thr His  Val Ala Arg 
    1490                 1495                 1500             


Ala Gln  Ala Gly Met Tyr His  Cys Leu Ala Glu Leu  Pro Thr Gly 
    1505                 1510                 1515             


Ala Ala  Ala Ser Ala Pro Val  Met Leu Arg Val Leu  Tyr Pro Pro 
    1520                 1525                 1530             


Lys Thr  Pro Thr Met Met Val  Phe Val Glu Pro Glu  Gly Gly Leu 
    1535                 1540                 1545             


Arg Gly  Ile Leu Asp Cys Arg  Val Asp Ser Glu Pro  Leu Ala Ser 
    1550                 1555                 1560             


Leu Thr  Leu His Leu Gly Ser  Arg Leu Val Ala Ser  Ser Gln Pro 
    1565                 1570                 1575             


Gln Gly  Ala Pro Ala Glu Pro  His Ile His Val Leu  Ala Ser Pro 
    1580                 1585                 1590             


Asn Ala  Leu Arg Val Asp Ile  Glu Ala Leu Arg Pro  Ser Asp Gln 
    1595                 1600                 1605             


Gly Glu  Tyr Ile Cys Ser Ala  Ser Asn Val Leu Gly  Ser Ala Ser 
    1610                 1615                 1620             


Thr Ser  Thr Tyr Phe Gly Val  Arg Ala Leu His Arg  Leu His Gln 
    1625                 1630                 1635             


Phe Gln  Gln Leu Leu Trp Val  Leu Gly Leu Leu Val  Gly Leu Leu 
    1640                 1645                 1650             


Leu Leu  Leu Leu Gly Leu Gly  Ala Cys Tyr Thr Trp  Ser Ser Leu 
    1655                 1660                 1665             


Ile Leu  Met Gln Pro His Val  Arg Pro Gln Pro Val  Pro His Pro 
    1670                 1675                 1680             


Trp Ala  Glu Val Ile 
    1685             


<210> 21
<211> 372
<212> PRT
<213> Homo sapiens

<400> 21
Met Ser Lys Ala Phe Gly Leu Leu Arg Gln Ile Cys Gln Ser Ile Leu 
1               5                   10                  15      


Ala Glu Ser Ser Gln Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu 
            20                  25                  30          


Asp Ser Asn Met Lys Arg Glu Gln Pro Arg Glu Arg Pro Arg Ala Trp 
        35                  40                  45              


Asp Tyr Pro His Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Thr 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Cys Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Thr Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Met Ile Arg Val Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp Gln Glu Thr Ala Tyr Leu Leu Val Tyr Met 
        355                 360                 365             


Lys Met Glu Cys 
    370         


<210> 22
<211> 246
<212> PRT
<213> Homo sapiens

<400> 22
Met Val Val Asp Phe Trp Thr Trp Glu Gln Thr Phe Gln Glu Leu Ile 
1               5                   10                  15      


Gln Glu Ala Lys Pro Arg Ala Thr Trp Thr Leu Lys Leu Asp Gly Asn 
            20                  25                  30          


Leu Gln Leu Asp Cys Leu Ala Gln Gly Trp Lys Gln Tyr Gln Gln Arg 
        35                  40                  45              


Ala Phe Gly Trp Phe Arg Cys Ser Ser Cys Gln Arg Ser Trp Ala Ser 
    50                  55                  60                  


Ala Gln Val Gln Ile Leu Cys His Thr Tyr Trp Glu His Trp Thr Ser 
65                  70                  75                  80  


Gln Gly Gln Val Arg Met Arg Leu Phe Gly Gln Arg Cys Gln Lys Cys 
                85                  90                  95      


Ser Trp Ser Gln Tyr Glu Met Pro Glu Phe Ser Ser Asp Ser Thr Met 
            100                 105                 110         


Arg Ile Leu Ser Asn Leu Val Gln His Ile Leu Lys Lys Tyr Tyr Gly 
        115                 120                 125             


Asn Gly Thr Arg Lys Ser Pro Glu Met Pro Val Ile Leu Glu Val Ser 
    130                 135                 140                 


Leu Glu Gly Ser His Asp Thr Ala Asn Cys Glu Ala Cys Thr Leu Gly 
145                 150                 155                 160 


Ile Cys Gly Gln Gly Leu Lys Ser Cys Met Thr Lys Pro Ser Lys Ser 
                165                 170                 175     


Leu Leu Pro His Leu Lys Thr Gly Asn Ser Ser Pro Gly Ile Gly Ala 
            180                 185                 190         


Val Tyr Leu Ala Asn Gln Ala Lys Asn Gln Ser Ala Glu Ala Lys Glu 
        195                 200                 205             


Ala Lys Gly Ser Gly Tyr Glu Lys Leu Gly Pro Ser Arg Asp Pro Asp 
    210                 215                 220                 


Pro Leu Asn Ile Cys Val Phe Ile Leu Leu Leu Val Phe Ile Val Val 
225                 230                 235                 240 


Lys Cys Phe Thr Ser Glu 
                245     


<210> 23
<211> 558
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Glu Leu Asn Thr His Val Asn Val Lys Glu Lys Ile Tyr Ala 
1               5                   10                  15      


Val Arg Ser Val Val Pro Asn Lys Ser Asn Asn Glu Ile Val Leu Val 
            20                  25                  30          


Leu Gln Gln Phe Asp Phe Asn Val Asp Lys Ala Val Gln Ala Phe Val 
        35                  40                  45              


Asp Gly Ser Ala Ile Gln Val Leu Lys Glu Trp Asn Met Thr Gly Lys 
    50                  55                  60                  


Lys Lys Asn Asn Lys Arg Lys Arg Ser Lys Ser Lys Gln His Gln Gly 
65                  70                  75                  80  


Asn Lys Asp Ala Lys Asp Lys Val Glu Arg Pro Glu Ala Gly Pro Leu 
                85                  90                  95      


Gln Pro Gln Pro Pro Gln Ile Gln Asn Gly Pro Met Asn Gly Cys Glu 
            100                 105                 110         


Lys Asp Ser Ser Ser Thr Asp Ser Ala Asn Glu Lys Pro Ala Leu Ile 
        115                 120                 125             


Pro Arg Glu Lys Lys Ile Ser Ile Leu Glu Glu Pro Ser Lys Ala Leu 
    130                 135                 140                 


Arg Gly Val Thr Glu Gly Asn Arg Leu Leu Gln Gln Lys Leu Ser Leu 
145                 150                 155                 160 


Asp Gly Asn Pro Lys Pro Ile His Gly Thr Thr Glu Arg Ser Asp Gly 
                165                 170                 175     


Leu Gln Trp Ser Ala Glu Gln Pro Cys Asn Pro Ser Lys Pro Lys Ala 
            180                 185                 190         


Lys Thr Ser Pro Val Lys Ser Asn Thr Pro Ala Ala His Leu Glu Ile 
        195                 200                 205             


Lys Pro Asp Glu Leu Ala Lys Lys Arg Gly Pro Asn Ile Glu Lys Ser 
    210                 215                 220                 


Val Lys Asp Leu Gln Arg Cys Thr Val Ser Leu Thr Arg Tyr Arg Val 
225                 230                 235                 240 


Met Ile Lys Glu Glu Val Asp Ser Ser Val Lys Lys Ile Lys Ala Ala 
                245                 250                 255     


Phe Ala Glu Leu His Asn Cys Ile Ile Asp Lys Glu Val Ser Leu Met 
            260                 265                 270         


Ala Glu Met Asp Lys Val Lys Glu Glu Ala Met Glu Ile Leu Thr Ala 
        275                 280                 285             


Arg Gln Lys Lys Ala Glu Glu Leu Lys Arg Leu Thr Asp Leu Ala Ser 
    290                 295                 300                 


Gln Met Ala Glu Met Gln Leu Ala Glu Leu Arg Ala Glu Ile Lys His 
305                 310                 315                 320 


Phe Val Ser Glu Arg Lys Tyr Asp Glu Glu Leu Gly Lys Ala Ala Arg 
                325                 330                 335     


Phe Ser Cys Asp Ile Glu Gln Leu Lys Ala Gln Ile Met Leu Cys Gly 
            340                 345                 350         


Glu Ile Thr His Pro Lys Asn Asn Tyr Ser Ser Arg Thr Pro Cys Ser 
        355                 360                 365             


Ser Leu Leu Pro Leu Leu Asn Ala His Ala Ala Thr Ser Gly Lys Gln 
    370                 375                 380                 


Ser Asn Phe Ser Arg Lys Ser Ser Thr His Asn Lys Pro Ser Glu Gly 
385                 390                 395                 400 


Lys Ala Ala Asn Pro Lys Met Val Ser Ser Leu Pro Ser Thr Ala Asp 
                405                 410                 415     


Pro Ser His Gln Thr Met Pro Ala Asn Lys Gln Asn Gly Ser Ser Asn 
            420                 425                 430         


Gln Arg Arg Arg Phe Asn Pro Gln Tyr His Asn Asn Arg Leu Asn Gly 
        435                 440                 445             


Pro Ala Lys Ser Gln Gly Ser Gly Asn Glu Ala Glu Pro Leu Gly Lys 
    450                 455                 460                 


Gly Asn Ser Arg His Glu His Arg Arg Gln Pro His Asn Gly Phe Arg 
465                 470                 475                 480 


Pro Lys Asn Lys Gly Gly Ala Lys Asn Gln Glu Ala Ser Leu Gly Met 
                485                 490                 495     


Lys Thr Pro Glu Ala Pro Ala His Ser Glu Lys Pro Arg Arg Arg Gln 
            500                 505                 510         


His Ala Ala Asp Thr Ser Glu Ala Arg Pro Phe Arg Gly Ser Val Gly 
        515                 520                 525             


Arg Val Ser Gln Cys Asn Leu Cys Pro Thr Arg Ile Glu Val Ser Thr 
    530                 535                 540                 


Asp Ala Ala Val Leu Ser Val Pro Ala Val Thr Leu Val Ala 
545                 550                 555             


