               SEQUENCE LISTING

<110> UNIVERSITA' DEGLI STUDI DI NAPOLI "FEDERICO II" DIPARTIMENTO DI MEDICINA MOLECOLARE E BIOTECNOLOGIE MEDICHE
      KEDRION S.P.A.

<120> Monoclonal antibodies able to bind E2 viral protein, preparation and use thereof

<130> 11565PTWO

<150> ITFI2012A000122
<151> 2012-06-15

<160> 81

<170> BiSSAP 1.0

<210> 1
<211> 104
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..104
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 1
Ala Glu Leu Val Arg Pro Gly Gly Ser Val Lys Leu Ser Cys Lys Ala 
1               5                   10                   15    
Ser Gly Tyr Ser Phe Thr Thr Tyr Trp Met Asn Trp Val Lys Gln Arg 
            20                   25                  30        
Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Gln Pro Ser Asp Ser 
        35                   40                  45            
Glu Thr Arg Leu Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Leu 
    50                   55                  60                
Asp Arg Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser Pro Thr Ser 
65                   70                  75                  80
Asp Asp Ser Ala Val Tyr Tyr Cys Ala Arg Thr Gly Arg Gly Asp Ala 
                85                   90                  95    
Trp Leu Thr Tyr Trp Gly Gln Gly 
            100                

<210> 2
<211> 94
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..94
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 2
Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Tyr 
1               5                   10                   15    
Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp 
            20                   25                  30        
Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val 
        35                   40                  45            
Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    50                   55                  60                
Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala 
65                   70                  75                  80
Ala Thr Tyr Tyr Cys Gln His Ile Arg Glu Leu Thr Arg Ser 
                85                   90                

<210> 3
<211> 104
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..104
<223> /mol_type="protein"
      /note="Mab V"
      /organism="Hepatitis C virus"

<400> 3
Ala Glu Leu Val Arg Pro Gly Gly Ser Val Lys Leu Ser Cys Lys Ala 
1               5                   10                   15    
Ser Gly Tyr Ser Phe Thr Thr Tyr Trp Met Asn Trp Val Lys Gln Arg 
            20                   25                  30        
Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Gln Pro Ser Asp Ser 
        35                   40                  45            
Glu Thr Arg Leu Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Leu 
    50                   55                  60                
Asp Arg Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser Pro Thr Ser 
65                   70                  75                  80
Asp Asp Ser Ala Val Tyr Tyr Cys Ala Arg Thr Gly Arg Gly Asp Ala 
                85                   90                  95    
Trp Leu Thr Tyr Trp Gly Gln Gly 
            100                

<210> 4
<211> 99
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..99
<223> /mol_type="protein"
      /note="Mab V"
      /organism="Hepatitis C virus"

<220> 
<221> VAR_SEQ
<222> 4
<223> metionine

<400> 4
Gln Lys Phe Xaa Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
1               5                   10                   15    
Lys Ala Ser Gln Asn Val Arg Thr Ala Val Ala Trp Tyr Gln Gln Lys 
            20                   25                  30        
Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His 
        35                   40                  45            
Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
    50                   55                  60                
Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Ala Tyr Phe 
65                   70                  75                  80
Cys Gln Gln Tyr Leu Asn Tyr Pro Arg Thr Arg Ser Glu Gly Gly Pro 
                85                   90                  95    
Ser Trp Asn 
            

<210> 5
<211> 101
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..101
<223> /mol_type="protein"
      /note="Mab VI"
      /organism="Hepatitis C virus"

<400> 5
Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala 
1               5                   10                   15    
Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Ile Lys Gln Arg 
            20                   25                  30        
Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Ala Tyr Ala Asp Gly 
        35                   40                  45            
Asn Ile Lys Ile Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Thr 
    50                   55                  60                
Val Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser 
65                   70                  75                  80
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Tyr Tyr Gly Leu Leu Phe Ala 
                85                   90                  95    
Tyr Trp Gly Gln Gly 
            100    

<210> 6
<211> 94
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..94
<223> /mol_type="protein"
      /note="Mab VI"
      /organism="Hepatitis C virus"

<400> 6
Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Tyr 
1               5                   10                   15    
Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp 
            20                   25                  30        
Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val 
        35                   40                  45            
Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    50                   55                  60                
Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala 
65                   70                  75                  80
Ala Thr Tyr Tyr Cys Gln His Ile Arg Glu Leu Thr Arg Ser 
                85                   90                

<210> 7
<211> 15
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..15
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 7
Lys Lys Cys Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile Cys 
1               5                   10                   15

<210> 8
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 8
Gln Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 9
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 9
Gln Leu Ile Asn Thr Asp Gly Ser Trp His 
1               5                   10

<210> 10
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 10
Gln Leu Val Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 11
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 11
Gln Leu Met Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 12
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 12
Gln Leu Ile Ser Thr Asn Gly Ser Trp His 
1               5                   10

<210> 13
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 13
Gln Leu Ile Asn Ser Asn Gly Ser Trp His 
1               5                   10

<210> 14
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 14
Gln Leu Ile Asn Thr Ser Gly Ser Trp His 
1               5                   10

<210> 15
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 15
Glu Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 16
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 16
Arg Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 17
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 17
His Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 18
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 18
Lys Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 19
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 19
Tyr Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 20
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 20
Ser Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 21
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 21
Asn Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 22
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 22
Gly Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 23
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 23
Gln Leu Ile Asn Thr Gly Gly Ser Trp His 
1               5                   10

<210> 24
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 24
Gln Leu Ile Asn Thr Asn Gly Gly Trp His 
1               5                   10

<210> 25
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 25
Gln Leu Thr Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 26
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 26
Gln Leu Met Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 27
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 27
Gln Leu Ile Asp Thr Asn Gly Ser Trp His 
1               5                   10

<210> 28
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 28
Gln Leu Ile Tyr Thr Asn Gly Ser Trp His 
1               5                   10

<210> 29
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 29
Gln Leu Ile Arg Thr Asn Gly Ser Trp His 
1               5                   10

<210> 30
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 30
Gln Leu Ile His Thr Asn Gly Ser Trp His 
1               5                   10

<210> 31
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 31
Gln Leu Ile Lys Thr Asn Gly Ser Trp His 
1               5                   10

<210> 32
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 32
Gln Leu Ile Tyr Thr Asn Gly Ser Trp His 
1               5                   10

<210> 33
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 33
Gln Leu Ile Asn Ala Asn Gly Ser Trp His 
1               5                   10

<210> 34
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 34
Gln Leu Ile Asn Thr Asp Gly Ser Trp His 
1               5                   10

<210> 35
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 35
Glu Leu Ile Asn Ser Asn Gly Ser Trp His 
1               5                   10

<210> 36
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 36
Glu Leu Val Asn Thr Ser Gly Ser Trp His 
1               5                   10

<210> 37
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 37
His Leu Val Asn Ser Asn Gly Ser Trp His 
1               5                   10

<210> 38
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 38
Asn Leu Val Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 39
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 39
Lys Leu Ile Asn Ser Asn Gly Ser Trp His 
1               5                   10

<210> 40
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 40
Arg Leu Ile Asn Ser Asn Gly Ser Trp His 
1               5                   10

<210> 41
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 41
Arg Leu Val Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 42
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 42
Ser Leu Ile Asn Ser Asn Gly Ser Trp His 
1               5                   10

<210> 43
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 43
Asn Leu Ile Lys Thr Asn Gly Ser Trp His 
1               5                   10

<210> 44
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 44
His Leu Val Asn Ser Asn Gly Ser Trp His 
1               5                   10

<210> 45
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 45
Gln Phe Val Asn Thr Asn Gly Ser Trp His 
1               5                   10

<210> 46
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 46
Gln Leu Val Lys Thr Asn Gly Ser Trp His 
1               5                   10

<210> 47
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 47
Gln Leu Val Asn Lys Asn Gly Ser Trp His 
1               5                   10

<210> 48
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 48
Gln Leu Val Asn Ala Asn Gly Ser Trp His 
1               5                   10

<210> 49
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 49
Gln Leu Val Asn Thr Ser Gly Ser Trp His 
1               5                   10

<210> 50
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 50
Gln Leu Val Asn Thr Asn Gly Arg Trp His 
1               5                   10

<210> 51
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 51
Gln Leu Met Tyr Thr Asn Gly Ser Trp His 
1               5                   10

<210> 52
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 52
Gln Leu Val Asn Ser Asn Gly Ser Trp His 
1               5                   10

<210> 53
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 53
Gln Leu Val Asn Lys Asn Gly Ser Trp His 
1               5                   10

<210> 54
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 54
Gln Leu Val Asn Arg Asn Gly Ser Trp His 
1               5                   10

<210> 55
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 55
Gln Leu Val Asn Thr Asp Gly Ser Trp His 
1               5                   10

<210> 56
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<220> 
<221> VAR_SEQ
<222> 7
<223> Glycine
      Serine

<400> 56
Gln Leu Ile Asn Ser Asn Xaa Ser Trp His 
1               5                   10

<210> 57
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 57
Gln Leu Val Asn Ala Ser Gly Ser Trp His 
1               5                   10

<210> 58
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 58
Gln Leu Val Lys Thr Glu Gly Asn Trp His 
1               5                   10

<210> 59
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 59
Gln Leu Val His Ala Asn Gly Ser Trp His 
1               5                   10

<210> 60
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 60
Gln Leu Val Asn Ser His Gly Ser Trp His 
1               5                   10

<210> 61
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 61
Gln Leu Val Asn Ser Asn Gly Ser Arg His 
1               5                   10

<210> 62
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 62
Gln Leu Val His Ser Asn Gly Ser Trp His 
1               5                   10

<210> 63
<211> 10
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 63
Gln Leu Ile Lys Asn Gly Ser Ser Trp His 
1               5                   10

<210> 64
<211> 311
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..311
<223> /mol_type="protein"
      /note="Mab II"
      /organism="Hepatitis C virus"

<400> 64
Gly Cys Thr Gly Ala Gly Cys Thr Gly Gly Thr Gly Ala Gly Gly Cys 
1               5                   10                   15    
Cys Thr Gly Gly Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Ala Ala 
            20                   25                  30        
Gly Cys Thr Gly Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys Gly 
        35                   40                  45            
Thr Cys Thr Gly Gly Cys Thr Ala Cys Thr Cys Cys Thr Thr Cys Ala 
    50                   55                  60                
Cys Cys Ala Cys Cys Thr Ala Cys Thr Gly Gly Ala Thr Gly Ala Ala 
65                   70                  75                  80
Cys Thr Gly Gly Gly Thr Gly Ala Ala Gly Cys Ala Gly Ala Gly Gly 
                85                   90                  95    
Cys Cys Thr Gly Gly Ala Cys Ala Ala Gly Gly Cys Cys Thr Thr Gly 
            100                  105                110        
Ala Gly Thr Gly Gly Ala Thr Thr Gly Gly Cys Ala Thr Gly Ala Thr 
        115                  120                125            
Thr Cys Ala Gly Cys Gly Thr Thr Cys Cys Gly Ala Thr Ala Gly Thr 
    130                  135                140                
Gly Ala Ala Ala Cys Thr Ala Gly Gly Thr Thr Ala Ala Ala Thr Cys 
145                  150                155                  160
Ala Gly Ala Ala Gly Thr Thr Cys Ala Ala Gly Gly Ala Cys Ala Ala 
                165                  170                175    
Gly Gly Cys Cys Ala Cys Ala Thr Thr Gly Ala Cys Thr Thr Thr Ala 
            180                  185                190        
Gly Ala Cys Ala Gly Ala Thr Cys Cys Thr Cys Cys Ala Gly Cys Ala 
        195                  200                205            
Cys Ala Gly Thr Cys Thr Ala Cys Ala Thr Gly Cys Ala Ala Cys Thr 
    210                  215                220                
Cys Ala Gly Thr Ala Gly Thr Cys Cys Gly Ala Cys Ala Thr Cys Thr 
225                  230                235                  240
Gly Ala Thr Gly Ala Cys Thr Cys Thr Gly Cys Gly Gly Thr Cys Thr 
                245                  250                255    
Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Ala Ala Gly Ala Ala Cys 
            260                  265                270        
Gly Gly Gly Cys Ala Gly Gly Gly Gly Gly Gly Ala Cys Gly Cys Thr 
        275                  280                285            
Thr Gly Gly Thr Thr Ala Ala Cys Thr Thr Ala Cys Thr Gly Gly Gly 
    290                  295                300                
Gly Cys Cys Ala Ala Gly Gly 
305                  310    

<210> 65
<211> 285
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..285
<223> /mol_type="protein"
      /note="Mab II"
      /organism="Hepatitis C virus"

<400> 65
Cys Cys Thr Gly Cys Thr Thr Cys Cys Thr Thr Ala Gly Cys Thr Gly 
1               5                   10                   15    
Thr Ala Thr Cys Thr Cys Thr Gly Gly Gly Gly Cys Ala Gly Ala Gly 
            20                   25                  30        
Gly Gly Cys Cys Ala Cys Cys Ala Thr Cys Thr Cys Ala Thr Ala Cys 
        35                   40                  45            
Ala Gly Gly Gly Cys Cys Ala Gly Cys Ala Ala Ala Ala Gly Thr Gly 
    50                   55                  60                
Thr Cys Ala Gly Thr Ala Cys Ala Thr Cys Thr Gly Gly Cys Thr Ala 
65                   70                  75                  80
Thr Ala Gly Thr Thr Ala Thr Ala Thr Gly Cys Ala Cys Thr Gly Gly 
                85                   90                  95    
Ala Ala Cys Cys Ala Ala Cys Ala Gly Ala Ala Ala Cys Cys Ala Gly 
            100                  105                110        
Gly Ala Cys Ala Gly Cys Cys Ala Cys Cys Cys Ala Gly Ala Cys Thr 
        115                  120                125            
Cys Cys Thr Cys Ala Thr Cys Thr Ala Thr Cys Thr Thr Gly Thr Ala 
    130                  135                140                
Thr Cys Cys Ala Ala Cys Cys Thr Ala Gly Ala Ala Thr Cys Thr Gly 
145                  150                155                  160
Gly Gly Gly Thr Cys Cys Cys Thr Gly Cys Cys Ala Gly Gly Thr Thr 
                165                  170                175    
Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr Gly Gly Gly Thr Cys Thr 
            180                  185                190        
Gly Gly Gly Ala Cys Ala Gly Ala Cys Thr Thr Cys Ala Cys Cys Cys 
        195                  200                205            
Thr Cys Ala Ala Cys Ala Thr Cys Cys Ala Thr Cys Cys Thr Gly Thr 
    210                  215                220                
Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala Thr Gly Cys Thr 
225                  230                235                  240
Gly Cys Ala Ala Cys Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr Cys 
                245                  250                255    
Ala Gly Cys Ala Cys Ala Thr Thr Ala Gly Gly Gly Ala Gly Cys Thr 
            260                  265                270        
Thr Ala Cys Ala Cys Gly Thr Thr Cys Gly Gly Ala Gly 
        275                  280                285

<210> 66
<211> 312
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..312
<223> /mol_type="protein"
      /note="Mab V"
      /organism="Hepatitis C virus"

<400> 66
Gly Cys Ala Gly Ala Ala Cys Thr Thr Gly Thr Gly Ala Ala Gly Cys 
1               5                   10                   15    
Cys Ala Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Cys Ala Ala 
            20                   25                  30        
Gly Thr Thr Gly Thr Cys Cys Thr Gly Cys Ala Cys Ala Gly Cys Thr 
        35                   40                  45            
Thr Cys Thr Gly Gly Cys Thr Thr Cys Ala Ala Cys Ala Thr Thr Ala 
    50                   55                  60                
Ala Ala Gly Ala Cys Ala Cys Cys Thr Ala Thr Ala Thr Gly Cys Ala 
65                   70                  75                  80
Cys Thr Gly Gly Ala Thr Ala Ala Ala Gly Cys Ala Gly Ala Gly Gly 
                85                   90                  95    
Cys Cys Thr Gly Ala Ala Cys Ala Gly Gly Gly Cys Cys Thr Gly Gly 
            100                  105                110        
Ala Gly Thr Gly Gly Ala Thr Thr Gly Gly Ala Ala Gly Gly Ala Thr 
        115                  120                125            
Thr Gly Cys Thr Thr Ala Thr Gly Cys Gly Gly Ala Thr Gly Gly Thr 
    130                  135                140                
Ala Ala Thr Ala Thr Thr Ala Ala Ala Ala Thr Thr Gly Ala Cys Cys 
145                  150                155                  160
Cys Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Gly Cys Ala Ala 
                165                  170                175    
Gly Gly Cys Cys Ala Cys Thr Ala Thr Ala Ala Cys Ala Ala Cys Ala 
            180                  185                190        
Gly Thr Cys Ala Cys Ala Thr Cys Thr Thr Cys Cys Ala Ala Cys Ala 
        195                  200                205            
Cys Ala Gly Cys Thr Thr Ala Cys Cys Thr Gly Cys Ala Gly Cys Thr 
    210                  215                220                
Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Thr Cys Ala 
225                  230                235                  240
Gly Ala Gly Gly Ala Cys Ala Cys Thr Gly Cys Cys Gly Thr Cys Thr 
                245                  250                255    
Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Thr Thr Ala Thr Thr Ala 
            260                  265                270        
Cys Gly Gly Cys Cys Thr Cys Thr Thr Ala Thr Thr Thr Gly Cys Thr 
        275                  280                285            
Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala 
    290                  295                300                
Cys Thr Cys Thr Gly Gly Thr Thr 
305                  310        

<210> 67
<211> 286
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..286
<223> /mol_type="protein"
      /note="Mab V"
      /organism="Hepatitis C virus"

<400> 67
Cys Cys Thr Gly Cys Thr Thr Cys Cys Thr Thr Ala Gly Cys Thr Gly 
1               5                   10                   15    
Thr Ala Thr Cys Thr Cys Thr Gly Gly Gly Gly Cys Ala Gly Ala Gly 
            20                   25                  30        
Gly Gly Cys Cys Ala Cys Cys Ala Thr Cys Thr Cys Ala Thr Ala Cys 
        35                   40                  45            
Ala Gly Gly Gly Cys Cys Ala Gly Cys Ala Ala Ala Ala Gly Thr Gly 
    50                   55                  60                
Thr Cys Ala Gly Thr Ala Cys Ala Thr Cys Thr Gly Gly Cys Thr Ala 
65                   70                  75                  80
Thr Ala Gly Thr Thr Ala Thr Ala Thr Gly Cys Ala Cys Thr Gly Gly 
                85                   90                  95    
Ala Ala Cys Cys Ala Ala Cys Ala Gly Ala Ala Ala Cys Cys Ala Gly 
            100                  105                110        
Gly Ala Cys Ala Gly Cys Cys Ala Cys Cys Cys Ala Gly Ala Cys Thr 
        115                  120                125            
Cys Cys Thr Cys Ala Thr Cys Thr Ala Thr Cys Thr Thr Gly Thr Ala 
    130                  135                140                
Thr Cys Cys Ala Ala Cys Cys Thr Ala Gly Ala Ala Thr Cys Thr Gly 
145                  150                155                  160
Gly Gly Gly Thr Cys Cys Cys Thr Gly Cys Cys Ala Gly Gly Thr Thr 
                165                  170                175    
Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr Gly Gly Gly Thr Cys Thr 
            180                  185                190        
Gly Gly Gly Ala Cys Ala Gly Ala Cys Thr Thr Cys Ala Cys Cys Cys 
        195                  200                205            
Thr Cys Ala Ala Cys Ala Thr Cys Cys Ala Thr Cys Cys Thr Gly Thr 
    210                  215                220                
Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala Thr Gly Cys Thr 
225                  230                235                  240
Gly Cys Ala Ala Cys Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr Cys 
                245                  250                255    
Ala Gly Cys Ala Cys Ala Thr Thr Ala Gly Gly Gly Ala Gly Cys Thr 
            260                  265                270        
Thr Ala Cys Asn Cys Gly Thr Thr Cys Gly Gly Ala Asn Gly 
        275                  280                285    

<210> 68
<211> 312
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..312
<223> /mol_type="protein"
      /note="Mab VI"
      /organism="Hepatitis C virus"

<400> 68
Gly Cys Ala Gly Ala Ala Cys Thr Thr Gly Thr Gly Ala Ala Gly Cys 
1               5                   10                   15    
Cys Ala Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Cys Ala Ala 
            20                   25                  30        
Gly Thr Thr Gly Thr Cys Cys Thr Gly Cys Ala Cys Ala Gly Cys Thr 
        35                   40                  45            
Thr Cys Thr Gly Gly Cys Thr Thr Cys Ala Ala Cys Ala Thr Thr Ala 
    50                   55                  60                
Ala Ala Gly Ala Cys Ala Cys Cys Thr Ala Thr Ala Thr Gly Cys Ala 
65                   70                  75                  80
Cys Thr Gly Gly Ala Thr Ala Ala Ala Gly Cys Ala Gly Ala Gly Gly 
                85                   90                  95    
Cys Cys Thr Gly Ala Ala Cys Ala Gly Gly Gly Cys Cys Thr Gly Gly 
            100                  105                110        
Ala Gly Thr Gly Gly Ala Thr Thr Gly Gly Ala Ala Gly Gly Ala Thr 
        115                  120                125            
Thr Gly Cys Thr Thr Ala Thr Gly Cys Gly Gly Ala Thr Gly Gly Thr 
    130                  135                140                
Ala Ala Thr Ala Thr Thr Ala Ala Ala Ala Thr Thr Gly Ala Cys Cys 
145                  150                155                  160
Cys Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Gly Cys Ala Ala 
                165                  170                175    
Gly Gly Cys Cys Ala Cys Thr Ala Thr Ala Ala Cys Ala Ala Cys Ala 
            180                  185                190        
Gly Thr Cys Ala Cys Ala Thr Cys Thr Thr Cys Cys Ala Ala Cys Ala 
        195                  200                205            
Cys Ala Gly Cys Thr Thr Ala Cys Cys Thr Gly Cys Ala Gly Cys Thr 
    210                  215                220                
Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Thr Cys Ala 
225                  230                235                  240
Gly Ala Gly Gly Ala Cys Ala Cys Thr Gly Cys Cys Gly Thr Cys Thr 
                245                  250                255    
Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Thr Thr Ala Thr Thr Ala 
            260                  265                270        
Cys Gly Gly Cys Cys Thr Cys Thr Thr Ala Thr Thr Thr Gly Cys Thr 
        275                  280                285            
Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala 
    290                  295                300                
Cys Thr Cys Thr Gly Gly Thr Thr 
305                  310        

<210> 69
<211> 286
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..286
<223> /mol_type="protein"
      /note="Mab VI"
      /organism="Hepatitis C virus"

<400> 69
Cys Cys Thr Gly Cys Thr Thr Cys Cys Thr Thr Ala Gly Cys Thr Gly 
1               5                   10                   15    
Thr Ala Thr Cys Thr Cys Thr Gly Gly Gly Gly Cys Ala Gly Ala Gly 
            20                   25                  30        
Gly Gly Cys Cys Ala Cys Cys Ala Thr Cys Thr Cys Ala Thr Ala Cys 
        35                   40                  45            
Ala Gly Gly Gly Cys Cys Ala Gly Cys Ala Ala Ala Ala Gly Thr Gly 
    50                   55                  60                
Thr Cys Ala Gly Thr Ala Cys Ala Thr Cys Thr Gly Gly Cys Thr Ala 
65                   70                  75                  80
Thr Ala Gly Thr Thr Ala Thr Ala Thr Gly Cys Ala Cys Thr Gly Gly 
                85                   90                  95    
Ala Ala Cys Cys Ala Ala Cys Ala Gly Ala Ala Ala Cys Cys Ala Gly 
            100                  105                110        
Gly Ala Cys Ala Gly Cys Cys Ala Cys Cys Cys Ala Gly Ala Cys Thr 
        115                  120                125            
Cys Cys Thr Cys Ala Thr Cys Thr Ala Thr Cys Thr Thr Gly Thr Ala 
    130                  135                140                
Thr Cys Cys Ala Ala Cys Cys Thr Ala Gly Ala Ala Thr Cys Thr Gly 
145                  150                155                  160
Gly Gly Gly Thr Cys Cys Cys Thr Gly Cys Cys Ala Gly Gly Thr Thr 
                165                  170                175    
Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr Gly Gly Gly Thr Cys Thr 
            180                  185                190        
Gly Gly Gly Ala Cys Ala Gly Ala Cys Thr Thr Cys Ala Cys Cys Cys 
        195                  200                205            
Thr Cys Ala Ala Cys Ala Thr Cys Cys Ala Thr Cys Cys Thr Gly Thr 
    210                  215                220                
Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala Thr Gly Cys Thr 
225                  230                235                  240
Gly Cys Ala Ala Cys Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr Cys 
                245                  250                255    
Ala Gly Cys Ala Cys Ala Thr Thr Ala Gly Gly Gly Ala Gly Cys Thr 
            260                  265                270        
Thr Ala Cys Asn Cys Gly Thr Thr Cys Gly Gly Ala Asn Gly 
        275                  280                285    

<210> 70
<211> 15
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..15
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 70
Lys Lys Cys Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile Cys 
1               5                   10                   15

<210> 71
<211> 14
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..14
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 71
Lys Lys Cys Ala Ala Ala Thr Asn Gly Ser Trp His Ile Cys 
1               5                   10                

<210> 72
<211> 15
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..15
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 72
Lys Lys Cys Gln Leu Ile Ala Ala Ala Gly Ser Trp His Ile Cys 
1               5                   10                   15

<210> 73
<211> 15
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..15
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 73
Lys Lys Cys Gln Leu Ile Asn Thr Asn Glu Glu Trp His Ile Cys 
1               5                   10                   15

<210> 74
<211> 15
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..15
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 74
Lys Lys Cys Gln Leu Ile Asn Thr Asn Gly Ser Ala Ala Ala Cys 
1               5                   10                   15

<210> 75
<211> 5
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 75
Asp Asp Asp Asp Tyr 
1               5

<210> 76
<211> 5
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 76
His Pro Phe His Leu 
1               5

<210> 77
<211> 11
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 77
Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile 
1               5                   10    

<210> 78
<211> 8
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..8
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 78
Gln Leu Ile Asn Thr Asn Gly Ser 
1               5            

<210> 79
<211> 17
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..17
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<220> 
<221> MOD_RES
<222> 4
<223> metil

<220> 
<221> MOD_RES
<222> 17
<223> metil

<400> 79
Lys Lys Cys Xaa Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile Cys 
1               5                   10                   15    
Xaa 
    

<210> 80
<211> 15
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..15
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 80
Lys Lys Cys Gln Leu Ile Asn Thr Asn Gly Ser Ala Ala Ala Cys 
1               5                   10                   15

<210> 81
<211> 5
<212> PRT
<213> Hepatitis C virus

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /organism="Hepatitis C virus"

<400> 81
Gly Ser Trp His Ile 
1               5

