                         SEQUENCE LISTING

<110>  NasVax Ltd.
 
<120>  HUMANIZED ANTIBODIES TO CLUSTER OF DIFFERENTIATION 3 (CD3)

<130>  36678-0002WO1

<150>  US 61/659,717
<151>  2012-06-14

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  1

Arg Tyr Thr Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  2

Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  3

Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  4

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  5

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  6

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  7
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated protein

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  8
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated protein

<400>  8

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105     


<210>  9
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  recombinent protein

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated protein

<400>  10

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  11
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant protein

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  12
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant protein

<400>  12

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  13
<211>  2163
<212>  DNA
<213>  Artificial

<220>
<223>  Recombinant DNA

<400>  13
caggtccagc tggtgcagtc tgggtctgaa ctgaaaaaac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aagacaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

aatcagaagt tcaaggacag ggccacattg actacagaca aatccaccag cacagcctac      240

atgcaactga gcagcctgag atctgaggac actgcagtct attactgtgc aagatattat      300

gatgatcatt actcccttga ctactggggc caaggcaccc ttgtcacagt ctcctcaggt      360

aagctttctg gggcaggccg ggcctgactt tggctggggg cagggagggg gctaaggtga      420

cgcaggtggc gccagccagg tgcacaccca atgcccatga gcccagacac tggaccctgc      480

atggaccatc gcggatagac aagaaccgag gggcctctgc gccctgggcc cagctctgtc      540

ccacaccgcg gtcacatggc accacctctc ttgcagcttc caccaagggc ccatccgtct      600

tccccctggc gccctgctcc aggagcacct ccgagagcac agccgccctg ggctgcctgg      660

tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg      720

gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc agcagcgtgg      780

tgaccgtgcc ctccagcagc ttgggcacga agacctacac ctgcaatgta gatcacaagc      840

ccagcaacac caaggtggac aagagagttg gtgagaggcc agcacaggga gggagggtgt      900

ctgctggaag ccaggctcag ccctcctgcc tggacgcacc ccggctgtgc agccccagcc      960

cagggcagca aggcaggccc catctgtctc ctcacctgga ggcctctgac caccccactc     1020

atgctcaggg agagggtctt ctggattttt ccaccaggct ccgggcagcc acaggctgga     1080

tgcccctacc ccaggccctg cgcatacagg ggcaggtgct gcgctcagac ctgccaagag     1140

ccatatccgg gaggaccctg cccctgacct aagcccaccc caaaggccaa actctccact     1200

ccctcagctc agacaccttc tctcctccca gatctgagta actcccaatc ttctctctgc     1260

agagtccaaa tatggtcccc catgcccacc atgcccaggt aagccaaccc aggcctcgcc     1320

ctccagctca aggcgggaca ggtgccctag agtagcctgc atccagggac aggccccagc     1380

cgggtgctga cgcatccacc tccatctctt cctcagcacc tgagttcctg gggggaccat     1440

cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg acccctgagg     1500

tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc aactggtacg     1560

tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag ttcaacagca     1620

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt     1680

acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc atctccaaag     1740

ccaaaggtgg gacccacggg gtgcgagggc cacatggaca gaggtcagct cggcccaccc     1800

tctgccctgg gagtgaccgc tgtgccaacc tctgtcccta cagggcagcc ccgagagcca     1860

caggtgtaca ccctgccccc atcccaggag gagatgacca agaaccaggt cagcctgacc     1920

tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag     1980

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     2040

tacagcaggc taaccgtgga caagagcagg tggcaggagg ggaatgtctt ctcatgctcc     2100

gtgatgcatg aggctctgca caaccactac acacagaaga gcctctccct gtctctgggt     2160

aaa                                                                   2163


<210>  14
<211>  1015
<212>  DNA
<213>  Artificial

<220>
<223>  Recombinant DNA

<400>  14
caaattgttc tcacccagtc tccagcaacc ctgtctctgt ctccagggga gagggccacc       60

atgtcctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagccaggc      120

aaagccccca aaagatggat ttatgacaca tccaaactgg cttctggagt cccttctagg      180

ttcaggggca gtgggtctgg gaccgattac actctcacaa tcagcagcct gcagcctgaa      240

gattttgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggcggcggg      300

acaaaggtgg aaataaaacg tgagtagaat ttaaactttg cttcctcagt tggatcccgc      360

aattctaaac tctgaggggg tcggatgacg tggccattct ttgcctaaag cattgagttt      420

actgcaaggt cagaaaagca tgcaaagccc tcagaatggc tgcaaagagc tccaacaaaa      480

caatttagaa ctttattaag gaataggggg aagctaggaa gaaactcaaa acatcaagat      540

tttaaatacg cttcttggtc tccttgctat aattatctgg gataagcatg ctgttttctg      600

tctgtcccta acatgccctg tgattatccg caaacaacac acccaagggc agaactttgt      660

tacttaaaca ccatcctgtt tgcttctttc ctcaggaact gtggctgcac catctgtctt      720

catcttcccg ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct      780

gaataacttc tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc      840

gggtaactcc caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag      900

cagcaccctg acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt      960

cacccatcag ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt          1015


<210>  15
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant protein

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 
    210                 215                 220                 


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
                245                 250                 255     


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
            260                 265                 270         


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
    290                 295                 300                 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
        355                 360                 365             


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
    370                 375                 380                 


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
                405                 410                 415     


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
            420                 425                 430         


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
        435                 440                 445             


Lys 
    


<210>  16
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant protein

<400>  16

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Ala Asp Thr Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  17
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant protein

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  18
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant protein

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant protein

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant protein

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  21
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  22

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  23

Arg Ala Thr Leu Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  24
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  24

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  25
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  25

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys 
            20              


<210>  26
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  26

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
1               5                   10                  15  


<210>  27
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  27

Gly Val Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  28
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  28

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  29
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  30
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  30

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  31
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  31

Arg Ala Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  32
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  32

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  33

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  34
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  34

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
1               5                   10                  15  


<210>  35
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  35

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  36
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically Generated Peptide

<400>  36

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  37
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  38

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  39
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  39

Arg Val Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  40
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  40

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  41
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  41

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  42
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  42

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
1               5                   10                  15  


<210>  43
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  43

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  44
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  44

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  45
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  45

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser 
            


<210>  46
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated peptide

<400>  46

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys 
            20  


<210>  47
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated protein

<400>  47

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  48
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated protein

<400>  48

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


