                               SEQUENCE LISTING

<110> ALKERMES, INC.
 
<120> LIGANDS MODIFIED BY CIRCULAR PERMUTATION AS AGONISTS AND 
      ANTAGONISTS

<130> 4000.3059 WO

<140>
<141>

<150> 61/778,575
<151> 2013-03-13

<150> 61/778,812
<151> 2013-03-13

<150> 61/723,081
<151> 2012-11-06

<150> 61/657,264
<151> 2012-06-08

<150> 61/657,378
<151> 2012-06-08

<150> 61/657,285
<151> 2012-06-08

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 170
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser 
1               5                   10                  15      


Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met Ser 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg 
        35                  40                  45              


Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys 
    50                  55                  60                  


Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu 
65                  70                  75                  80  


Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe 
                85                  90                  95      


Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe 
            100                 105                 110         


Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu 
        115                 120                 125             


Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu 
    130                 135                 140                 


Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr 
145                 150                 155                 160 


Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln 
                165                 170 


<210> 2
<211> 516
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
cagaaccagt ggctgcagga catgaccacc cacctgatcc tgcggtcctt caaagagttc       60

ctgcagtcct ccctgcgggc cctgagacag atgagcggag gatctggcgg aggctcctct      120

gagcggatcg acaagcagat ccggtacatc ctggacggca tctccgccct gcggaaagag      180

acatgcaaca agtccaacat gtgcgagtcc agcaaagagg ccctggccga gaacaacctg      240

aacctgccca agatggctga gaaggacggc tgcttccagt ccggcttcaa cgaagagact      300

tgcctggtca agatcatcac cggcctgctg gaatttgagg tgtacctgga atacctgcag      360

aacagattcg agtcctccga ggaacaggcc agagccgtgc agatgtccac caaggtgctg      420

atccagtttc tgcagaagaa ggccaagaac ctggacgcta tcaccacccc cgaccctacc      480

accaatgcct ccctgctgac caagctgcag tgataa                                516


<210> 3
<211> 212
<212> PRT
<213> Homo sapiens

<400> 3
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210> 4
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser 
1               5                   10                  15      


Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met Ser 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg 
        35                  40                  45              


Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys 
    50                  55                  60                  


Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu 
65                  70                  75                  80  


Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe 
                85                  90                  95      


Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe 
            100                 105                 110         


Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu 
        115                 120                 125             


Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu 
    130                 135                 140                 


Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr 
145                 150                 155                 160 


Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Ser Glu Leu Leu Asp 
                165                 170                 175     


Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val Gln Leu His Ser 
            180                 185                 190         


Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys Met Asp Tyr Phe 
        195                 200                 205             


His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn His Phe Thr Ile 
    210                 215                 220                 


Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala Ser Ser Val Thr 
225                 230                 235                 240 


Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu 
                245                 250                 255     


Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser 
            260                 265                 270         


Gly Leu Val Pro Arg Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505                 510     


<210> 5
<211> 1539
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
caaaaccagt ggctccagga tatgaccacc cacctcatcc tcagaagttt caaggagttc       60

ctccagtcca gcctgagggc tctgaggcaa atgagcggag gctccggcgg aggcagctcc      120

gagagaatcg acaagcagat caggtacatc ctcgatggca tcagcgccct cagaaaagaa      180

acctgtaata agagcaacat gtgtgagagc agcaaggaag ccctcgccga gaacaatctg      240

aacctcccca aaatggctga gaaggacgga tgcttccaga gcggcttcaa tgaggagaca      300

tgcctcgtga agatcatcac aggactcctg gagttcgaag tctacctgga gtacctccag      360

aacaggttcg aatccagcga ggaacaggct agggctgtgc agatgtccac caaggtgctg      420

atccagttcc tccagaagaa ggccaagaat ctggatgcca tcaccacacc cgatcctaca      480

accaacgcca gcctgctgac caagctccag gcctccgaac tcctggaccc ttgtggctac      540

atttcccctg aaagccctgt ggtgcaactc cacagcaatt tcacagccgt ctgtgtgctc      600

aaggagaagt gcatggacta ctttcacgtg aatgctaatt atatcgtgtg gaagacaaac      660

cacttcacca tccccaagga gcagtatacc atcatcaaca ggaccgcctc cagcgtgaca      720

ttcaccgaca tcgcttccct caacattcag ctgacctgca atatcctcac cttcggccag      780

ctggagcaga acgtgtacgg aatcaccatc attagcggcc tcgtccctag aggctccgaa      840

cccaagtcct ccgataaaac ccatacctgc cccccttgcc ctgctcccga actcctcggc      900

ggccccagcg tgtttctctt ccctcccaag cccaaagata ccctgatgat cagcaggaca      960

cccgaagtca cctgcgtggt ggtcgacgtg tcccacgagg accccgaggt caaattcaac     1020

tggtacgtcg atggcgtgga ggtgcataat gctaagacca agcccaggga ggagcagtac     1080

aactccacat acagggtggt ctccgtcctg accgtgctgc atcaagactg gctgaacggc     1140

aaggagtata agtgcaaggt gagcaataaa gccctccccg cccctattga gaagaccatt     1200

tccaaggcca agggccagcc tagagaacct caagtctaca cactcccccc ctccagggag     1260

gagatgacca aaaatcaggt ctccctgacc tgcctggtga agggcttcta tcctagcgac     1320

atcgccgtcg agtgggagag caacggacag cccgagaaca actacaaaac cacacctccc     1380

gtgctcgaca gcgacggcag cttcttcctg tactccaagc tcaccgtgga taagtccagg     1440

tggcagcaag gcaacgtgtt tagctgcagc gtgatgcacg aagctctcca caaccactat     1500

acccagaagt ccctcagcct cagccctggc aagtagtga                            1539


<210> 6
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp 
1               5                   10                  15      


Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys 
            20                  25                  30          


Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys 
        35                  40                  45              


Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr 
    50                  55                  60                  


Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu 
65                  70                  75                  80  


Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala 
                85                  90                  95      


Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala 
            100                 105                 110         


Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser 
        115                 120                 125             


Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr 
    130                 135                 140                 


Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu 
145                 150                 155                 160 


Arg Ala Leu Arg Gln Met Ser Glu Leu Leu Asp Pro Cys Gly Tyr Ile 
                165                 170                 175     


Ser Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val 
            180                 185                 190         


Cys Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn 
        195                 200                 205             


Tyr Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr 
    210                 215                 220                 


Thr Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala 
225                 230                 235                 240 


Ser Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu 
                245                 250                 255     


Glu Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Val Pro Arg 
            260                 265                 270         


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        275                 280                 285             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    290                 295                 300                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
305                 310                 315                 320 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                325                 330                 335     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            340                 345                 350         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        355                 360                 365             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    370                 375                 380                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
385                 390                 395                 400 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                405                 410                 415     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            420                 425                 430         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        435                 440                 445             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    450                 455                 460                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
465                 470                 475                 480 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                485                 490                 495     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505     


<210> 7
<211> 1524
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
ctgacctcca gcgaaaggat cgacaagcag atcaggtaca tcctcgacgg catctccgct       60

ctcagaaagg agacctgcaa caagagcaac atgtgcgaga gcagcaagga agccctggct      120

gagaacaatc tcaacctgcc caagatggcc gaaaaggatg gatgcttcca gagcggcttt      180

aacgaggaga cctgcctcgt gaagatcatc accggcctgc tcgagtttga ggtgtatctc      240

gagtacctgc agaataggtt cgagagcagc gaggaacagg ctagagctgt ccagatgtcc      300

accaaggtgc tgatccagtt cctgcaaaag aaggccaaga atctcgacgc tatcaccacc      360

cctgacccta ccacaaacgc cagcctgctg accaagctgc aggcccaaaa ccaatggctc      420

caggacatga caacccacct gatcctgagg agcttcaagg agttcctcca atcctccctc      480

agggccctga gacagatgag cgaactgctc gacccttgtg gatacattag ccctgaatcc      540

cccgtggtgc agctgcatag caatttcacc gccgtgtgcg tgctcaaaga gaagtgcatg      600

gactacttcc atgtgaacgc caactacatc gtgtggaaga ccaaccattt caccatcccc      660

aaggagcaat acaccatcat caacagaacc gccagcagcg tcacattcac cgacatcgcc      720

tccctgaaca tccaactgac atgcaacatt ctcaccttcg gccagctgga gcaaaatgtg      780

tacggcatca ccatcattag cggcctcgtc cctagaggct ccgaacccaa gtcctccgat      840

aaaacccata cctgcccccc ttgccctgct cccgaactcc tcggcggccc cagcgtgttt      900

ctcttccctc ccaagcccaa agataccctg atgatcagca ggacacccga agtcacctgc      960

gtggtggtcg acgtgtccca cgaggacccc gaggtcaaat tcaactggta cgtcgatggc     1020

gtggaggtgc ataatgctaa gaccaagccc agggaggagc agtacaactc cacatacagg     1080

gtggtctccg tcctgaccgt gctgcatcaa gactggctga acggcaagga gtataagtgc     1140

aaggtgagca ataaagccct ccccgcccct attgagaaga ccatttccaa ggccaagggc     1200

cagcctagag aacctcaagt ctacacactc cccccctcca gggaggagat gaccaaaaat     1260

caggtctccc tgacctgcct ggtgaagggc ttctatccta gcgacatcgc cgtcgagtgg     1320

gagagcaacg gacagcccga gaacaactac aaaaccacac ctcccgtgct cgacagcgac     1380

ggcagcttct tcctgtactc caagctcacc gtggataagt ccaggtggca gcaaggcaac     1440

gtgtttagct gcagcgtgat gcacgaagct ctccacaacc actataccca gaagtccctc     1500

agcctcagcc ctggcaagta gtga                                            1524


<210> 8
<211> 160
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr 
1               5                   10                  15      


Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met 
            20                  25                  30          


Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu 
        35                  40                  45              


Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala 
    50                  55                  60                  


Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile 
65                  70                  75                  80  


Thr Asp Phe Thr Met Gln Phe Val Ser Ser Gly Gly Ser Gly Gly Ser 
                85                  90                  95      


Gly Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln Gln 
            100                 105                 110         


Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His Leu 
        115                 120                 125             


Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe Val 
    130                 135                 140                 


Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys 
145                 150                 155                 160 


<210> 9
<211> 486
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
gagaagaacc tctacctctc ctgcgtgctg aaggacgaca agcccacact ccagctggag       60

tccgtggacc ccaagaacta ccccaagaag aagatggaga agcggttcgt gttcaacaag      120

atcgagatca acaacaagct ggagttcgag agcgcccagt tccccaactg gtacatttcc      180

acctcccagg ccgagaacat gcccgtcttt ctgggcggaa ccaagggcgg ccaggacatc      240

accgacttca ccatgcagtt cgtctccagc ggaggaagcg gaggcagcgg agctcccgtg      300

aggagcctga actgcaccct gagggacagc cagcagaagt ccctggtgat gtccggaccc      360

tacgaactga aggccctcca tctgcaagga caggatatgg agcagcaggt ggtgttctcc      420

atgtccttcg tccagggcga agagtccaac gacaagatcc ccgtggccct gggcctgaaa      480

tagtga                                                                 486


<210> 10
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Arg Asp Tyr Lys Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu Val Ser Ser Ala Asn 
        35                  40                  45              


Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro Asn Glu His Lys Gly 
    50                  55                  60                  


Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr Pro Val Ser Thr Glu 
65                  70                  75                  80  


Gln Ala Ser Arg Ile His Gln His Lys Glu Lys Leu Trp Phe Val Pro 
                85                  90                  95      


Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys Val Val Arg Asn Ser 
            100                 105                 110         


Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys Phe Val Glu Asn Glu 
        115                 120                 125             


Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe Lys Gln Lys Leu Pro 
    130                 135                 140                 


Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr Met Glu Phe Phe Lys 
145                 150                 155                 160 


Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp Tyr Lys Asp Cys Lys 
                165                 170                 175     


Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly Val Lys Asp Arg Leu 
            180                 185                 190         


Ile Val Met Asn Val Ala Glu Lys His Arg Gly Asn Tyr Thr Cys His 
        195                 200                 205             


Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro Ile Thr Arg Val Ile 
    210                 215                 220                 


Glu Phe Ile Thr Leu Glu Glu Asn Ser Gly Gly Ser Gly Asn Lys Leu 
225                 230                 235                 240 


Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
                245                 250                 255     


Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp 
            260                 265                 270         


Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser Gly Gly Ser Gly Gly 
        275                 280                 285             


Ser Gly Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln 
    290                 295                 300                 


Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His 
305                 310                 315                 320 


Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe 
                325                 330                 335     


Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
            340                 345                 350         


Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro 
        355                 360                 365             


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys 
    370                 375                 380                 


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn 
385                 390                 395         


<210> 11
<211> 1197
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atggacgcta tgaagcgggg actgtgctgc gtgctcctgc tgtgcggcgc tgtctttgtc       60

agcgcccggg actataagga cgatgatgac aaggacaagt gcaaggagcg ggaggagaag      120

atcatcctgg tgagctccgc caacgagatt gacgtccggc cctgccctct caaccccaac      180

gagcataagg gcaccatcac ctggtacaaa gacgacagca aaacacccgt ctccaccgag      240

caagcctccc ggattcacca gcacaaggag aagctctggt tcgtgcccgc taaggtggag      300

gattccggac actactactg tgtggtccgg aactccagct actgcctgag gattaagatc      360

agcgctaagt tcgtcgagaa cgagcccaac ctctgctaca atgcccaggc catcttcaag      420

cagaagctcc ctgtggctgg agacggaggc ctggtctgcc cctacatgga gttcttcaag      480

aacgagaata acgagctgcc taagctgcag tggtacaagg actgcaaacc cctgctcctc      540

gacaacatcc acttctccgg cgtcaaggac cggctgatcg tcatgaacgt ggccgagaag      600

cacaggggca actatacctg tcacgccagc tacacctacc tgggaaagca gtatcctatc      660

accagggtga ttgagttcat cacactcgag gaaaacagcg gcggcagcgg caacaagctg      720

gagttcgagt ccgcccagtt tcctaactgg tacatctcca caagccaggc cgagaacatg      780

cctgtcttcc tgggcggcac caaaggcggc caagatatca ccgacttcac catgcagttt      840

gtgagctccg gaggctccgg aggaagcgga gctcctgtgc ggtccctgaa ttgcaccctg      900

cgggattccc aacagaagag cctggtgatg tccggcccct acgagctcaa ggccctccat      960

ctgcaaggcc aggacatgga gcagcaggtg gtcttcagca tgagcttcgt gcagggagag     1020

gagtccaacg ataagatccc cgtcgctctc ggactcaagg agaagaacct gtacctctcc     1080

tgcgtgctga aggacgataa gcccaccctc cagctggaat ccgtggaccc caagaactac     1140

cccaagaaaa aaatggaaaa gcggtttgtc tttaacaaga tcgagattaa ctagtga        1197


<210> 12
<211> 539
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
1               5                   10                  15      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            20                  25                  30          


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        35                  40                  45              


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Ser Ser 
    50                  55                  60                  


Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 
65                  70                  75                  80  


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
                85                  90                  95      


Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
            100                 105                 110         


His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 
        115                 120                 125             


Asn Leu Ala Gln Gly Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp 
    130                 135                 140                 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
145                 150                 155                 160 


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
                165                 170                 175     


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
            180                 185                 190         


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
        195                 200                 205             


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
    210                 215                 220                 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
225                 230                 235                 240 


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
                245                 250                 255     


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
            260                 265                 270         


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
        275                 280                 285             


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
305                 310                 315                 320 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                325                 330                 335     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            340                 345                 350         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        355                 360                 365             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    370                 375                 380                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
385                 390                 395                 400 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                405                 410                 415     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            420                 425                 430         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        435                 440                 445             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    450                 455                 460                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
465                 470                 475                 480 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                485                 490                 495     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            500                 505                 510         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        515                 520                 525             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535                 


<210> 13
<211> 1623
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
tccaagaact tccacctgag gcctcgggac ctgatctcca acatcaacgt gatcgtgctg       60

gaactgaagg gctccgagac aaccttcatg tgcgagtacg ccgacgagac agctaccatc      120

gtggaatttc tgaaccggtg gatcaccttc tgccagtcca tcatctccac cctgaccggc      180

ggctcctcca gcaccaagaa aacccagctg cagctggaac atctgctgct ggacctgcag      240

atgatcctga acggcatcaa caactacaag aaccccaagc tgacccggat gctgaccttc      300

aagttctaca tgcccaagaa ggccaccgaa ctgaaacatc tgcagtgcct ggaagaagaa      360

ctgaagcccc tggaagaggt gctgaacctg gctcagggat ctggcggcgg atctgagctg      420

tgcgacgacg accctcctga gatccctcac gccaccttca aggccatggc ttacaaagag      480

ggcaccatgc tgaactgcga gtgcaagaga ggcttccggc ggatcaagtc cggctccctg      540

tacatgctgt gcaccggcaa ctccagccac tcctcctggg acaaccagtg ccagtgcacc      600

tcctctgcca cccggaacac caccaaacaa gtgacccccc agcccgagga acagaaagag      660

cgcaagacca ccgagatgca gtcccccatg cagcctgtgg accaggcttc tctgcctggc      720

cactgcagag agcctccacc ttgggagaac gaggctaccg agagaatcta ccacttcgtc      780

gtgggccaga tggtgtacta ccagtgcgtg cagggctacc gcgccctgca tagaggacct      840

gctgagtccg tgtgcaagat gacccacggc aagacccggt ggacccagcc tcagctgatc      900

tgtacaggcg gcggaggctc cgagcctaag tcctccgata agacccacac ctgtcccccc      960

tgtcctgccc ctgaactgct gggaggccct tccgtgttcc tgttcccccc aaagcccaag     1020

gacaccctga tgatctcccg gacccccgaa gtgacctgcg tggtggtgga tgtgtcccac     1080

gaggaccctg aagtgaagtt caattggtac gtggacggcg tggaagtgca caacgccaag     1140

accaagccca gagaggaaca gtacaactcc acctaccggg tggtgtccgt gctgaccgtg     1200

ctgcaccagg attggctgaa tggcaaagag tacaagtgca aggtgtccaa caaggccctg     1260

ccagccccca tcgaaaagac catctccaag gccaagggcc agccccggga accccaggtg     1320

tacacactgc cccctagccg ggaagagatg accaagaacc aggtgtccct gacctgtctc     1380

gtgaagggct tctacccctc cgatatcgcc gtggaatggg agtccaacgg ccagcctgag     1440

aacaattata agaccacccc ccctgtgctg gactccgacg gctcattctt cctgtacagc     1500

aagctgacag tggacaagtc ccggtggcag cagggcaacg tgttctcctg ctccgtgatg     1560

cacgaggccc tgcacaacca ctacacccag aagtccctgt ccctgtctcc cggcaagtga     1620

tga                                                                   1623


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ser Gly Gly Ser Gly Gly Gly 
1               5           


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Gly Ser Gly Gly Ser Gly 
1               5           


<210> 16
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Gly 
1       


<210> 17
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Met Gly 
1       


<210> 18
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Met Gly Gly 
1           


<210> 19
<211> 269
<212> PRT
<213> Homo sapiens

<400> 19
Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210> 20
<211> 153
<212> PRT
<213> Homo sapiens

<400> 20
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 21
<211> 918
<212> PRT
<213> Homo sapiens

<400> 21
Met Leu Thr Leu Gln Thr Trp Val Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210> 22
<211> 569
<212> PRT
<213> Homo sapiens

<400> 22
Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Asn Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Ser Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210> 23
<211> 272
<212> PRT
<213> Homo sapiens

<400> 23
Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210> 24
<211> 142
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
1               5                   10                  15      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            20                  25                  30          


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        35                  40                  45              


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Ser Ser 
    50                  55                  60                  


Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 
65                  70                  75                  80  


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
                85                  90                  95      


Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
            100                 105                 110         


His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 
        115                 120                 125             


Asn Leu Ala Gln Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140         


<210> 25
<211> 539
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
1               5                   10                  15      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            20                  25                  30          


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        35                  40                  45              


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Ser Ser 
    50                  55                  60                  


Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 
65                  70                  75                  80  


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
                85                  90                  95      


Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
            100                 105                 110         


His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 
        115                 120                 125             


Asn Leu Ala Gln Gly Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp 
    130                 135                 140                 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
145                 150                 155                 160 


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
                165                 170                 175     


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
            180                 185                 190         


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
        195                 200                 205             


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
    210                 215                 220                 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
225                 230                 235                 240 


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
                245                 250                 255     


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
            260                 265                 270         


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
        275                 280                 285             


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
305                 310                 315                 320 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                325                 330                 335     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            340                 345                 350         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        355                 360                 365             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    370                 375                 380                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
385                 390                 395                 400 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                405                 410                 415     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            420                 425                 430         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        435                 440                 445             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    450                 455                 460                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
465                 470                 475                 480 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                485                 490                 495     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            500                 505                 510         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        515                 520                 525             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535                 


<210> 26
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
1               5                   10                  15      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            20                  25                  30          


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        35                  40                  45              


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Ser Ser 
    50                  55                  60                  


Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 
65                  70                  75                  80  


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
                85                  90                  95      


Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
            100                 105                 110         


His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 
        115                 120                 125             


Asn Leu Ala Gln Gly Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp 
    130                 135                 140                 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
145                 150                 155                 160 


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
                165                 170                 175     


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
            180                 185                 190         


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
        195                 200                 205             


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
    210                 215                 220                 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
225                 230                 235                 240 


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
                245                 250                 255     


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
            260                 265                 270         


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
        275                 280                 285             


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Asp 
    290                 295                 300                 


Tyr Lys Asp Asp Asp Asp Lys 
305                 310     


<210> 27
<211> 418
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Ile Thr Cys Pro Pro Pro 
225                 230                 235                 240 


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
                245                 250                 255     


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            260                 265                 270         


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        275                 280                 285             


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Gly Gly Ser Glu 
    290                 295                 300                 


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
305                 310                 315                 320 


Val Gln Met Phe Ile Asn Gly Gly Gly Ser Asn Trp Val Asn Val Ile 
                325                 330                 335     


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
            340                 345                 350         


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
        355                 360                 365             


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
    370                 375                 380                 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
385                 390                 395                 400 


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
                405                 410                 415     


Glu Cys 
        


<210> 28
<211> 194
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ile Thr Cys Pro Pro Pro 
1               5                   10                  15      


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
            20                  25                  30          


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
        35                  40                  45              


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
    50                  55                  60                  


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Gly Gly Ser Glu 
65                  70                  75                  80  


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
                85                  90                  95      


Val Gln Met Phe Ile Asn Gly Gly Gly Ser Asn Trp Val Asn Val Ile 
            100                 105                 110         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        115                 120                 125             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    130                 135                 140                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
145                 150                 155                 160 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                165                 170                 175     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            180                 185                 190         


Glu Cys 
        

