                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
       THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE 
       DEPARTMENT OF VETERANS AFFAIRS
       Chen, Beibei
       Mallampalli, Rama K.
 
<120>  FBXO3 INHIBITORS

<130>  8123-89258-02

<150>  US 61/657,423
<151>  2012-06-08

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (278)..(400)
<223>  ApaG motif

<400>  1

Met Ala Ala Met Glu Thr Glu Thr Ala Pro Leu Thr Leu Glu Ser Leu 
1               5                   10                  15      


Pro Thr Asp Pro Leu Leu Leu Ile Leu Ser Phe Leu Asp Tyr Arg Asp 
            20                  25                  30          


Leu Ile Asn Cys Cys Tyr Val Ser Arg Arg Leu Ser Gln Leu Ser Ser 
        35                  40                  45              


His Asp Pro Leu Trp Arg Arg His Cys Lys Lys Tyr Trp Leu Ile Ser 
    50                  55                  60                  


Glu Glu Glu Lys Thr Gln Lys Asn Gln Cys Trp Lys Ser Leu Phe Ile 
65                  70                  75                  80  


Asp Thr Tyr Ser Asp Val Gly Arg Tyr Ile Asp His Tyr Ala Ala Ile 
                85                  90                  95      


Lys Lys Ala Trp Asp Asp Leu Lys Lys Tyr Leu Glu Pro Arg Cys Pro 
            100                 105                 110         


Arg Met Val Leu Ser Leu Lys Glu Gly Ala Arg Glu Glu Asp Leu Asp 
        115                 120                 125             


Ala Val Glu Ala Gln Ile Gly Cys Lys Leu Pro Asp Asp Tyr Arg Cys 
    130                 135                 140                 


Ser Tyr Arg Ile His Asn Gly Gln Lys Leu Val Val Pro Gly Leu Leu 
145                 150                 155                 160 


Gly Ser Met Ala Leu Ser Asn His Tyr Arg Ser Glu Asp Leu Leu Asp 
                165                 170                 175     


Val Asp Thr Ala Ala Gly Gly Phe Gln Gln Arg Gln Gly Leu Lys Tyr 
            180                 185                 190         


Cys Leu Pro Leu Thr Phe Cys Ile His Thr Gly Leu Ser Gln Tyr Ile 
        195                 200                 205             


Ala Val Glu Ala Ala Glu Gly Arg Asn Lys Asn Glu Val Phe Tyr Gln 
    210                 215                 220                 


Cys Pro Asp Gln Met Ala Arg Asn Pro Ala Ala Ile Asp Met Phe Ile 
225                 230                 235                 240 


Ile Gly Ala Thr Phe Thr Asp Trp Phe Thr Ser Tyr Val Lys Asn Val 
                245                 250                 255     


Val Ser Gly Gly Phe Pro Ile Ile Arg Asp Gln Ile Phe Arg Tyr Val 
            260                 265                 270         


His Asp Pro Glu Cys Val Ala Thr Thr Gly Asp Ile Thr Val Ser Val 
        275                 280                 285             


Ser Thr Ser Phe Leu Pro Glu Leu Ser Ser Val His Pro Pro His Tyr 
    290                 295                 300                 


Phe Phe Thr Tyr Arg Ile Arg Ile Glu Met Ser Lys Asp Ala Leu Pro 
305                 310                 315                 320 


Glu Lys Ala Cys Gln Leu Asp Ser Arg Tyr Trp Arg Ile Thr Asn Ala 
                325                 330                 335     


Lys Gly Asp Val Glu Glu Val Gln Gly Pro Gly Val Val Gly Glu Phe 
            340                 345                 350         


Pro Ile Ile Ser Pro Gly Arg Val Tyr Glu Tyr Thr Ser Cys Thr Thr 
        355                 360                 365             


Phe Ser Thr Thr Ser Gly Tyr Met Glu Gly Tyr Tyr Thr Phe His Phe 
    370                 375                 380                 


Leu Tyr Phe Lys Asp Lys Ile Phe Asn Val Ala Ile Pro Arg Phe His 
385                 390                 395                 400 


Met Ala Cys Pro Thr Phe Arg Val Ser Ile Ala Arg Leu Glu Met Gly 
                405                 410                 415     


Pro Asp Glu Tyr Glu Glu Met Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Glu Asp Glu Asp Asp Asp Ser Ala Asp Met Asp Glu Ser Asp Glu Asp 
        435                 440                 445             


Asp Glu Glu Glu Arg Arg Arg Arg Val Phe Asp Val Pro Ile Arg Arg 
    450                 455                 460                 


Arg Arg Cys Ser Arg Leu Phe 
465                 470     


