                         SEQUENCE LISTING

<110>  Flynn, Daniel L.
       Kaufman, Michael D.
 
<120>  DIHYDRONAPHTHYRIDINES AND RELATED COMPOUNDS USEFUL AS KINASE 
       INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

<130>  DECP-060/00US

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-KIT with N-terminal GST fusion

<400>  1

Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro Thr Arg Leu Leu 
1               5                   10                  15      


Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu Tyr Glu Arg Asp 
            20                  25                  30          


Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu Gly Leu Glu Phe 
        35                  40                  45              


Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys Leu Thr Gln Ser 
    50                  55                  60                  


Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn Met Leu Gly Gly 
65                  70                  75                  80  


Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu Gly Ala Val Asp 
                85                  90                  95      


Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr 
            100                 105                 110         


Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu Met Leu Lys Met Phe 
        115                 120                 125             


Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn Gly Asp His Val Thr 
    130                 135                 140                 


His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp Val Val Leu Tyr Met 
145                 150                 155                 160 


Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu Val Cys Phe Lys Lys 
                165                 170                 175     


Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys 
            180                 185                 190         


Tyr Ile Trp Pro Leu Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp 
        195                 200                 205             


His Pro Pro Lys Ser Asp Leu Val Pro Arg His Asn Gln Thr Ser Leu 
    210                 215                 220                 


Tyr Lys Lys Ala Gly Ser Ala Ala Ala Val Leu Glu Glu Asn Leu Tyr 
225                 230                 235                 240 


Phe Gln Gly Thr Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln 
                245                 250                 255     


Trp Lys Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp 
            260                 265                 270         


Pro Thr Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg 
        275                 280                 285             


Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val 
    290                 295                 300                 


Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val 
305                 310                 315                 320 


Ala Val Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala 
                325                 330                 335     


Leu Met Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn 
            340                 345                 350         


Ile Val Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val 
        355                 360                 365             


Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg 
    370                 375                 380                 


Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala 
385                 390                 395                 400 


Ala Leu Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp 
                405                 410                 415     


Ser Thr Asn Glu Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val 
            420                 425                 430         


Pro Thr Lys Ala Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile 
        435                 440                 445             


Glu Arg Asp Val Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu 
    450                 455                 460                 


Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met 
465                 470                 475                 480 


Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg 
                485                 490                 495     


Asn Ile Leu Leu Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly 
            500                 505                 510         


Leu Ala Arg Asp Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn 
        515                 520                 525             


Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys 
    530                 535                 540                 


Val Tyr Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp 
545                 550                 555                 560 


Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp 
                565                 570                 575     


Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro 
            580                 585                 590         


Glu His Ala Pro Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp 
        595                 600                 605             


Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile 
    610                 615                 620                 


Glu Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala 
625                 630                 635                 640 


Asn Cys Ser Pro Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg 
                645                 650                 655     


Ile Asn Ser Val Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val 
            660                 665                 670         


His Asp Asp Val 
        675     


<210>  2
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-KIT (V654A)

<400>  2

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Pro Trp Gly Ser Thr Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val 
        35                  40                  45              


Gln Trp Lys Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile 
    50                  55                  60                  


Asp Pro Thr Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn 
65                  70                  75                  80  


Arg Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val 
                85                  90                  95      


Val Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr 
            100                 105                 110         


Val Ala Val Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu 
        115                 120                 125             


Ala Leu Met Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met 
    130                 135                 140                 


Asn Ile Ala Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu 
145                 150                 155                 160 


Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg 
                165                 170                 175     


Arg Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu 
            180                 185                 190         


Ala Ala Leu Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser 
        195                 200                 205             


Asp Ser Thr Asn Glu Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val 
    210                 215                 220                 


Val Pro Thr Lys Ala Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr 
225                 230                 235                 240 


Ile Glu Arg Asp Val Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala 
                245                 250                 255     


Leu Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly 
            260                 265                 270         


Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala 
        275                 280                 285             


Arg Asn Ile Leu Leu Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe 
    290                 295                 300                 


Gly Leu Ala Arg Asp Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly 
305                 310                 315                 320 


Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn 
                325                 330                 335     


Cys Val Tyr Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu 
            340                 345                 350         


Trp Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val 
        355                 360                 365             


Asp Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser 
    370                 375                 380                 


Pro Glu His Ala Pro Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp 
385                 390                 395                 400 


Asp Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu 
                405                 410                 415     


Ile Glu Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu 
            420                 425                 430         


Ala Asn Cys Ser Pro Asn Arg Gln Lys Pro Val Val Asp His Ser Val 
        435                 440                 445             


Arg Ile Asn Ser Val Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu 
    450                 455                 460                 


Val His Asp Asp Val 
465                 


<210>  3
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-KIT (D816H)

<400>  3

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Glu Phe Lys Gly Leu Arg Arg Gln Thr Tyr Lys Tyr 
225                 230                 235                 240 


Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val Glu Glu Ile 
                245                 250                 255     


Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp 
            260                 265                 270         


His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu 
        275                 280                 285             


Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala Tyr Gly Leu 
    290                 295                 300                 


Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met Leu Lys Pro 
305                 310                 315                 320 


Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu Leu Lys Val 
                325                 330                 335     


Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu Leu Gly Ala 
            340                 345                 350         


Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr 
        355                 360                 365             


Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys 
    370                 375                 380                 


Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu 
385                 390                 395                 400 


His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp 
                405                 410                 415     


Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala Asp Lys Arg 
            420                 425                 430         


Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala 
        435                 440                 445             


Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser 
    450                 455                 460                 


Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala Ser Lys Asn 
465                 470                 475                 480 


Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Thr His Gly 
                485                 490                 495     


Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg His Ile Lys Asn 
            500                 505                 510         


Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp 
        515                 520                 525             


Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp 
    530                 535                 540                 


Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser 
545                 550                 555                 560 


Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr Lys Met Ile 
                565                 570                 575     


Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro Ala Glu Met 
            580                 585                 590         


Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro 
        595                 600                 605             


Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln 
    610                 615                 620 


<210>  4
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-KIT (D816V)

<400>  4

Met Glu His His His His His His His His Glu Tyr Met Pro Met Glu 
1               5                   10                  15      


Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
            20                  25                  30          


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
        35                  40                  45              


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
    50                  55                  60                  


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
65                  70                  75                  80  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
                85                  90                  95      


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
            100                 105                 110         


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
        115                 120                 125             


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
    130                 135                 140                 


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
145                 150                 155                 160 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
                165                 170                 175     


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
            180                 185                 190         


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
        195                 200                 205             


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
    210                 215                 220                 


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
225                 230                 235                 240 


His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Val 
                245                 250                 255     


Leu Glu Glu Asn Leu Tyr Phe Gln Gly Thr Tyr Lys Tyr Leu Gln Lys 
            260                 265                 270         


Pro Met Tyr Glu Val Gln Trp Lys Val Val Glu Glu Ile Asn Gly Asn 
        275                 280                 285             


Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp His Lys Trp 
    290                 295                 300                 


Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly 
305                 310                 315                 320 


Ala Phe Gly Lys Val Val Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser 
                325                 330                 335     


Asp Ala Ala Met Thr Val Ala Val Lys Met Leu Lys Pro Ser Ala His 
            340                 345                 350         


Leu Thr Glu Arg Glu Ala Leu Met Ser Glu Leu Lys Val Leu Ser Tyr 
        355                 360                 365             


Leu Gly Asn His Met Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Ile 
    370                 375                 380                 


Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu 
385                 390                 395                 400 


Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln 
                405                 410                 415     


Glu Asp His Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu His Ser Lys 
            420                 425                 430         


Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp Met Lys Pro 
        435                 440                 445             


Gly Val Ser Tyr Val Val Pro Thr Lys Ala Asp Lys Arg Arg Ser Val 
    450                 455                 460                 


Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile Met Glu 
465                 470                 475                 480 


Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr 
                485                 490                 495     


Gln Val Ala Lys Gly Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His 
            500                 505                 510         


Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Thr His Gly Arg Ile Thr 
        515                 520                 525             


Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ile Lys Asn Asp Ser Asn 
    530                 535                 540                 


Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro 
545                 550                 555                 560 


Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp Val Trp Ser 
                565                 570                 575     


Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr 
            580                 585                 590         


Pro Gly Met Pro Val Asp Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly 
        595                 600                 605             


Phe Arg Met Leu Ser Pro Glu His Ala Pro Ala Glu Met Tyr Asp Ile 
    610                 615                 620                 


Met Lys Thr Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys 
625                 630                 635                 640 


Gln Ile Val Gln Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr Asn His 
                645                 650                 655     


Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys Pro Val 
            660                 665                 670         


Val Asp His Ser Val Arg Ile Asn Ser Val Gly Ser Thr Ala Ser Ser 
        675                 680                 685             


Ser Gln Pro Leu Leu Val His Asp Asp Val 
    690                 695             


<210>  5
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cKIT-VVDV

<400>  5

Met Glu His His His His His His His His Glu Tyr Met Pro Met Glu 
1               5                   10                  15      


Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
            20                  25                  30          


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
        35                  40                  45              


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
    50                  55                  60                  


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
65                  70                  75                  80  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
                85                  90                  95      


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
            100                 105                 110         


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
        115                 120                 125             


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
    130                 135                 140                 


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
145                 150                 155                 160 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
                165                 170                 175     


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
            180                 185                 190         


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
        195                 200                 205             


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
    210                 215                 220                 


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
225                 230                 235                 240 


His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Val 
                245                 250                 255     


Leu Glu Glu Asn Leu Tyr Phe Gln Gly Thr Tyr Lys Tyr Leu Gln Lys 
            260                 265                 270         


Pro Met Tyr Glu Val Gln Trp Lys Glu Glu Ile Asn Gly Asn Asn Tyr 
        275                 280                 285             


Val Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp His Lys Trp Glu Phe 
    290                 295                 300                 


Pro Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe 
305                 310                 315                 320 


Gly Lys Val Val Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala 
                325                 330                 335     


Ala Met Thr Val Ala Val Lys Met Leu Lys Pro Ser Ala His Leu Thr 
            340                 345                 350         


Glu Arg Glu Ala Leu Met Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly 
        355                 360                 365             


Asn His Met Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly 
    370                 375                 380                 


Pro Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn 
385                 390                 395                 400 


Phe Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp 
                405                 410                 415     


His Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu His Ser Lys Glu Ser 
            420                 425                 430         


Ser Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp Met Lys Pro Gly Val 
        435                 440                 445             


Ser Tyr Val Val Pro Thr Lys Ala Asp Lys Arg Arg Ser Val Arg Ile 
    450                 455                 460                 


Gly Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile Met Glu Asp Asp 
465                 470                 475                 480 


Glu Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val 
                485                 490                 495     


Ala Lys Gly Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp 
            500                 505                 510         


Leu Ala Ala Arg Asn Ile Leu Leu Thr His Gly Arg Ile Thr Lys Ile 
        515                 520                 525             


Cys Asp Phe Gly Leu Ala Arg Val Ile Lys Asn Asp Ser Asn Tyr Val 
    530                 535                 540                 


Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser 
545                 550                 555                 560 


Ile Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly 
                565                 570                 575     


Ile Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly 
            580                 585                 590         


Met Pro Val Asp Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg 
        595                 600                 605             


Met Leu Ser Pro Glu His Ala Pro Ala Glu Met Tyr Asp Ile Met Lys 
    610                 615                 620                 


Thr Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile 
625                 630                 635                 640 


Val Gln Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr 
                645                 650                 655     


Ser Asn Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys Pro Val Val Asp 
            660                 665                 670         


His Ser Val Arg Ile Asn Ser Val Gly Ser Thr Ala Ser Ser Ser Gln 
        675                 680                 685             


Pro Leu Leu Val His Asp Asp Val 
    690                 695     


<210>  6
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cKIT-T670I

<400>  6

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Pro Trp Gly Ser Thr Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val 
        35                  40                  45              


Gln Trp Lys Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile 
    50                  55                  60                  


Asp Pro Thr Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn 
65                  70                  75                  80  


Arg Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val 
                85                  90                  95      


Val Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr 
            100                 105                 110         


Val Ala Val Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu 
        115                 120                 125             


Ala Leu Met Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met 
    130                 135                 140                 


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu 
145                 150                 155                 160 


Val Ile Ile Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg 
                165                 170                 175     


Arg Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu 
            180                 185                 190         


Ala Ala Leu Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser 
        195                 200                 205             


Asp Ser Thr Asn Glu Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val 
    210                 215                 220                 


Val Pro Thr Lys Ala Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr 
225                 230                 235                 240 


Ile Glu Arg Asp Val Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala 
                245                 250                 255     


Leu Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly 
            260                 265                 270         


Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala 
        275                 280                 285             


Arg Asn Ile Leu Leu Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe 
    290                 295                 300                 


Gly Leu Ala Arg Asp Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly 
305                 310                 315                 320 


Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn 
                325                 330                 335     


Cys Val Tyr Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu 
            340                 345                 350         


Trp Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val 
        355                 360                 365             


Asp Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser 
    370                 375                 380                 


Pro Glu His Ala Pro Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp 
385                 390                 395                 400 


Asp Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu 
                405                 410                 415     


Ile Glu Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu 
            420                 425                 430         


Ala Asn Cys Ser Pro Asn Arg Gln Lys Pro Val Val Asp His Ser Val 
        435                 440                 445             


Arg Ile Asn Ser Val Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu 
    450                 455                 460                 


Val His Asp Asp Val 
465                 


