                         LISTADO DE SECUENCIAS


<110>  Servicio Andaluz de Salud
<110>  Universidad de Sevilla
<110>  Consejo Superior de Investigaciones Cientficas
 
<120>  Mtodo de obtencin de datos tiles para el diagnstico, 
       pronstico y clasificacin de los pacientes con enfermedad 
       pulmonar obstructiva crnica (EPOC)y/o cncer de pulmn.

<130>  PCT-06449

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  5928
<212>  DNA
<213>  Homo sapiens

<400>  1
ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt       60

cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac      120

ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc      180

gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag      240

aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct      300

gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc      360

cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg      420

gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg      480

cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggcg agaggcgtgc      540

tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca      600

atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg      660

ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt      720

catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg      780

aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg      840

gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga      900

acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct      960

cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg     1020

ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc     1080

agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca     1140

gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc     1200

tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc     1260

atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc     1320

aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt     1380

ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta     1440

ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc     1500

cagtgcaaga ttcttcttca gtaccactgc ccacattcct ggttgctgga gggagcctgg     1560

ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc     1620

gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc     1680

cggagaggcc tcgacccacc ccagtgcttg ttcctctcat ctccccaccg gtgtccccca     1740

gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga     1800

gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc     1860

agcagcctgg accctgtgga tgataaaaca caaacgggct cagcaaaaga tgcttctcac     1920

tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga     1980

aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa     2040

cctccctttc caaatgccca gcttaaaggg gctagagtga acttgggcca ctgtgaagag     2100

aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg     2160

gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca     2220

ccctcaggca ggtgggatgg atttccagcc aaagcctcct ccagccgcca tgctcctggc     2280

ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgcct tagcaaattc     2340

tgtttttcta ggcctgggga cggcttttac ttaaaccgcc aaggctgggg gaagaagctc     2400

tctcctccct ttcttcccta cagttgaaaa acagctgagg gtgagtgggt gaataataca     2460

gtatctcagg gcctggtcgt tttcaacaga attataatta gttcctcatt agcattttgc     2520

taaatgtgaa tgatgatcct aggcatttgc tgaatacaga ggcaactgca ttggctttgg     2580

gttgcaggac ctcaggtgag aagcagagga aggagaggag aggggcacag ggtctctacc     2640

atcccctgta gagtgggagc tgagtggggg atcacagcct ctgaaaacca atgttctctc     2700

ttctccacct cccacaaagg agagctagca gcagggaggg cttctgccat ttctgagatc     2760

aaaacggttt tactgcagct ttgtttgttg tcagctgaac ctgggtaact agggaagata     2820

atattaagga agacaatgtg aaaagaaaaa tgagcctggc aagaatgtgt ttaaacttgg     2880

tttttaaaaa actgctgact gttttctctt gagagggtgg aatatccaat attcgctgtg     2940

tcagcataga agtaacttac ttaggtgtgg gggaagcacc ataactttgt ttagcccaaa     3000

accaagtcaa gtgaaaaagg aggaagagaa aaaatatttt cctgccaggc atggtggccc     3060

acgcacttcg ggaggtcgag gcaggaggat cacttgagtc cagaagtttg agatcagcct     3120

gggcaatgtg ataaaacccc atctctacaa aaagcataaa aattagccaa gtgtggtaga     3180

gtgtgcctga agtcccagat acttgggggg ctgaggtggg aggatctctt gagcctggga     3240

ggtcaaggct gcagtgagcc gagattgcac cactgcactc cagcctgggt gacagagcaa     3300

gtgagaccct gtctcaaaaa aagaaaaaga aaaagaaaaa atattttccc tattagagaa     3360

gagattgtgg tttcattctg tattttgttt ttgtcttaaa aagtggaaaa atagcctgcc     3420

tcttctctac tctagggaaa aaccagcgtg tgactactcc cccaggtggt tatggagagg     3480

gtgtccggtc cctgtcccag tgccgagaag gaagcctccc acgactgccc ggcagggtcc     3540

tagaaattcc ccaccctgaa agccctgagc tttctgctat caaagaggtt ttaaaaaaat     3600

cccatttaaa aaaaatccct tacctcggtg ccttcctctt tttatttagt tccttgagtt     3660

gattcagctc tgcaagaatt gaagcaggac taaatgtcta gttgtaacac catgattaac     3720

cacttcagct gacttttctg tccgagcttt gaaaattcag tggtgttagt ggttacccag     3780

ttagctctca agttatcagg gtattccaga gtggggatat gatttaaatc agccgtgtaa     3840

ccatggaccc aatatttacc agaccacaaa acttttctaa tactctaccc tcttagaaaa     3900

accaccacca tcaccagaca ggtgcgaaag gatgaaagtg accatgtttt gtttacggtt     3960

ttccaggttt aagctgttac tgtcttcagt aagccgtgat tttcattgct gggcttgtct     4020

gtagatttta gaccctattg ctgcttgagg caactcatct taggttggca aaaaggcagg     4080

atggccgggc gcggtggctc acgcctgtaa tcctagcact ttgggaggcc aaggtgggag     4140

gattgcttga gctcaggagt ttgagaccaa cctgggtaac atagtgagac accatctcta     4200

ttatgaacaa taacagttaa gaaaaaaaaa ggcaggcagg cggttatggt ggttccctcc     4260

catcccacca cataaagttt ctgagacttg agaacagcaa aatgctgtta aagggaaata     4320

ttaagaatga gaatctgcag taagggtgat tctgtgccca cagttcttca attctttata     4380

ccgttttacc cacatgtggt gttaccaaag ccgggcagaa ccatgctagc ggaagatgtg     4440

aaatccagat agctcattat tgccaagagc taggcagctt tgatctccaa attgttattg     4500

ctttcatttt tattgtaatg gaattgcttt gttttgtttt tttgtttttg tattgaagag     4560

ggttgttttc cctttatttt tcataagcta atgtaaatga agaaaaaatg tcttctctgg     4620

gctgtaggcc tggctcagcg tacacaggta tacatcctaa gctctctatg ttctctaatc     4680

tgtggtgact gaacatgtgt ctcaatgcac ggggcatttc tacctgtgtt tctgcagcac     4740

ccccactgcc ttgagtcccc agcagtgctg ttatttgcct aacacctgta gccatctgcc     4800

acgcagccag acgtgaaacg ctgagacaga gaccatttag gttaaatacg acagcttatc     4860

ctgctgggtg gggaaagtaa aaaatatgct ggttcaaggc ctaaagtaaa atgatcaata     4920

atgtttgtag cattaatgaa atattttcaa gaaatgtgtc caggggtagc actggctatg     4980

ttgacgaggc ctttggtaac tcagagagct cttggccctg atggggactt gcccttacgc     5040

tttctttatc aggctctgag ttcacacgga gcctctggca cttccctgct gtcttgggag     5100

aaaggaaact ggttgccgcg gcaggttgtg gaatctgttg ctggaaccag gctggaagcc     5160

cacctggtag tgaacagggc ccagtggggc aggctgggca tgttgtggtc tatgggtttg     5220

tttcctggag aatgttcagg aatgtcttcc cagctgcttt ggtgctgagc tctattatct     5280

cacagcacgt ccagaaggct aacccaggtg gggaggatgc tgacaccagc tccaggtgga     5340

gttggtggtc ttaatttgga gatgcagggg caacctgtga ccctttgagg caagagccct     5400

gcacccagct gtcccgtgca gccgtgggca ggggctgcac acggaggggc aggcgggcca     5460

gttcagggtc cgtgccaggc cctcctcagt gccctgtgaa ggcctcctgt cctccgtgcg     5520

gctgggcacc agcaccaggg agtttctatg gcaaccttag tgattattaa ggaacactgt     5580

cagttttatg aacatatgct caaatgaaat tctactttag gaggaaagga ttggaacagc     5640

atgtcacaag gctgttaatt aacagagaga ccttattgga tggagatcac atctgttaaa     5700

tagaatacct caactctacg ttgttttctt ggagataaat aatagtttca agtttttgtt     5760

tgtttgtttt acctaattac ctgaaagcaa ataccaaagg ctgatgtctg tatatggggc     5820

aaagggtcag tatatttttc agtgtttttt tttctaccag ctattttgca tttaaagtga     5880

acattgtgtt tggaataaat actcttaaaa aataaaaaaa aaaaaaaa                  5928


<210>  2
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210>  3
<211>  2943
<212>  DNA
<213>  Homo sapiens

<400>  3
accaggcaac accattgaag gctcatatgt aaaaatccat gccttccttt ctcccaatct       60

ccattcccaa acttagccac tggcttctgg ctgaggcctt acgcatacct cccggggctt      120

gcacacacct tcttctacag aagacacacc ttgggcatat cctacagaag accaggcttc      180

tctctggtcc ttggtagagg gctactttac tgtaacaggg ccagggtgga gagttctctc      240

ctgaagctcc atcccctcta taggaaatgt gttgacaata ttcagaagag taagaggatc      300

aagacttctt tgtgctcaaa taccactgtt ctcttctcta ccctgcccta accaggagct      360

tgtcacccca aactctgagg tgatttatgc cttaatcaag caaacttccc tcttcagaaa      420

agatggctca ttttccctca aaagttgcca ggagctgcca agtattctgc caattcaccc      480

tggagcacaa tcaacaaatt cagccagaac acaactacag ctactattag aactattatt      540

attaataaat tcctctccaa atctagcccc ttgacttcgg atttcacgat ttctcccttc      600

ctcctagaaa cttgataagt ttcccgcgct tccctttttc taagactaca tgtttgtcat      660

cttataaagc aaaggggtga ataaatgaac caaatcaata acttctggaa tatctgcaaa      720

caacaataat atcagctatg ccatctttca ctattttagc cagtatcgag ttgaatgaac      780

atagaaaaat acaaaactga attcttccct gtaaattccc cgttttgacg acgcacttgt      840

agccacgtag ccacgcctac ttaagacaat tacaaaaggc gaagaagact gactcaggct      900

taagctgcca gccagagagg gagtcatttc attggcgttt gagtcagcaa agaagtcaag      960

atggccaaag ttccagacat gtttgaagac ctgaagaact gttacagtga aaatgaagaa     1020

gacagttcct ccattgatca tctgtctctg aatcagaaat ccttctatca tgtaagctat     1080

ggcccactcc atgaaggctg catggatcaa tctgtgtctc tgagtatctc tgaaacctct     1140

aaaacatcca agcttacctt caaggagagc atggtggtag tagcaaccaa cgggaaggtt     1200

ctgaagaaga gacggttgag tttaagccaa tccatcactg atgatgacct ggaggccatc     1260

gccaatgact cagaggaaga aatcatcaag cctaggtcag caccttttag cttcctgagc     1320

aatgtgaaat acaactttat gaggatcatc aaatacgaat tcatcctgaa tgacgccctc     1380

aatcaaagta taattcgagc caatgatcag tacctcacgg ctgctgcatt acataatctg     1440

gatgaagcag tgaaatttga catgggtgct tataagtcat caaaggatga tgctaaaatt     1500

accgtgattc taagaatctc aaaaactcaa ttgtatgtga ctgcccaaga tgaagaccaa     1560

ccagtgctgc tgaaggagat gcctgagata cccaaaacca tcacaggtag tgagaccaac     1620

ctcctcttct tctgggaaac tcacggcact aagaactatt tcacatcagt tgcccatcca     1680

aacttgttta ttgccacaaa gcaagactac tgggtgtgct tggcaggggg gccaccctct     1740

atcactgact ttcagatact ggaaaaccag gcgtaggtct ggagtctcac ttgtctcact     1800

tgtgcagtgt tgacagttca tatgtaccat gtacatgaag aagctaaatc ctttactgtt     1860

agtcatttgc tgagcatgta ctgagccttg taattctaaa tgaatgttta cactctttgt     1920

aagagtggaa ccaacactaa catataatgt tgttatttaa agaacaccct atattttgca     1980

tagtaccaat cattttaatt attattcttc ataacaattt taggaggacc agagctactg     2040

actatggcta ccaaaaagac tctacccata ttacagatgg gcaaattaag gcataagaaa     2100

actaagaaat atgcacaata gcagttgaaa caagaagcca cagacctagg atttcatgat     2160

ttcatttcaa ctgtttgcct tctactttta agttgctgat gaactcttaa tcaaatagca     2220

taagtttctg ggacctcagt tttatcattt tcaaaatgga gggaataata cctaagcctt     2280

cctgccgcaa cagtttttta tgctaatcag ggaggtcatt ttggtaaaat acttcttgaa     2340

gccgagcctc aagatgaagg caaagcacga aatgttattt tttaattatt atttatatat     2400

gtatttataa atatatttaa gataattata atatactata tttatgggaa ccccttcatc     2460

ctctgagtgt gaccaggcat cctccacaat agcagacagt gttttctggg ataagtaagt     2520

ttgatttcat taatacaggg cattttggtc caagttgtgc ttatcccata gccaggaaac     2580

tctgcattct agtacttggg agacctgtaa tcatataata aatgtacatt aattaccttg     2640

agccagtaat tggtccgatc tttgactctt ttgccattaa acttacctgg gcattcttgt     2700

ttcaattcca cctgcaatca agtcctacaa gctaaaatta gatgaactca actttgacaa     2760

ccatgagacc actgttatca aaactttctt ttctggaatg taatcaatgt ttcttctagg     2820

ttctaaaaat tgtgatcaga ccataatgtt acattattat caacaatagt gattgataga     2880

gtgttatcag tcataactaa ataaagcttg caacaaaatt ctctgacaaa aaaaaaaaaa     2940

aaa                                                                   2943


<210>  4
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210>  5
<211>  2354
<212>  DNA
<213>  Homo sapiens

<400>  5
gctcagggca catgcctccc ctccccaggc cgcggcccag ctgaccctcg gggctccccc       60

ggcagcggac agggaagggt taaaggcccc cggctccctg ccccctgccc tggggaaccc      120

ctggccctgt ggggacatga actgtgtttg ccgcctggtc ctggtcgtgc tgagcctgtg      180

gccagataca gctgtcgccc ctgggccacc acctggcccc cctcgagttt ccccagaccc      240

tcgggccgag ctggacagca ccgtgctcct gacccgctct ctcctggcgg acacgcggca      300

gctggctgca cagctgaggg acaaattccc agctgacggg gaccacaacc tggattccct      360

gcccaccctg gccatgagtg cgggggcact gggagctcta cagctcccag gtgtgctgac      420

aaggctgcga gcggacctac tgtcctacct gcggcacgtg cagtggctgc gccgggcagg      480

tggctcttcc ctgaagaccc tggagcccga gctgggcacc ctgcaggccc gactggaccg      540

gctgctgcgc cggctgcagc tcctgatgtc ccgcctggcc ctgccccagc cacccccgga      600

cccgccggcg cccccgctgg cgcccccctc ctcagcctgg gggggcatca gggccgccca      660

cgccatcctg ggggggctgc acctgacact tgactgggcc gtgaggggac tgctgctgct      720

gaagactcgg ctgtgacccg gggcccaaag ccaccaccgt ccttccaaag ccagatctta      780

tttatttatt tatttcagta ctgggggcga aacagccagg tgatcccccc gccattatct      840

ccccctagtt agagacagtc cttccgtgag gcctgggggg catctgtgcc ttatttatac      900

ttatttattt caggagcagg ggtgggaggc aggtggactc ctgggtcccc gaggaggagg      960

ggactggggt cccggattct tgggtctcca agaagtctgt ccacagactt ctgccctggc     1020

tcttccccat ctaggcctgg gcaggaacat atattattta tttaagcaat tacttttcat     1080

gttggggtgg ggacggaggg gaaagggaag cctgggtttt tgtacaaaaa tgtgagaaac     1140

ctttgtgaga cagagaacag ggaattaaat gtgtcataca tatccacttg agggcgattt     1200

gtctgagagc tggggctgga tgcttgggta actggggcag ggcaggtgga ggggagacct     1260

ccattcaggt ggaggtcccg agtgggcggg gcagcgactg ggagatgggt cggtcaccca     1320

gacagctctg tggaggcagg gtctgagcct tgcctggggc cccgcactgc atagggcctt     1380

ttgtttgttt tttgagatgg agtctcgctc tgttgcctag gctggagtgc agtgaggcaa     1440

tctgaggtca ctgcaacctc cacctcccgg gttcaagcaa ttctcctgcc tcagcctccc     1500

gattagctgg gatcacaggt gtgcaccacc atgcccagct aattatttat ttcttttgta     1560

tttttagtag agacagggtt tcaccatgtt ggccaggctg gtttcgaact cctgacctca     1620

ggtgatcctc ctgcctcggc ctcccaaagt gctgggatta caggtgtgag ccaccacacc     1680

tgacccatag gtcttcaata aatatttaat ggaaggttcc acaagtcacc ctgtgatcaa     1740

cagtacccgt atgggacaaa gctgcaaggt caagatggtt cattatggct gtgttcacca     1800

tagcaaactg gaaacaatct agatatccaa cagtgagggt taagcaacat ggtgcatctg     1860

tggatagaac gccacccagc cgcccggagc agggactgtc attcagggag gctaaggaga     1920

gaggcttgct tgggatatag aaagatatcc tgacattggc caggcatggt ggctcacgcc     1980

tgtaatcctg gcactttggg aggacgaagc gagtggatca ctgaagtcca agagttcgag     2040

accggcctgc gagacatggc aaaaccctgt ctcaaaaaag aaagaatgat gtcctgacat     2100

gaaacagcag gctacaaaac cactgcatgc tgtgatccca attttgtgtt tttctttcta     2160

tatatggatt aaaacaaaaa tcctaaaggg aaatacgcca aaatgttgac aatgactgtc     2220

tccaggtcaa aggagagagg tgggattgtg ggtgactttt aatgtgtatg attgtctgta     2280

ttttacagaa tttctgccat gactgtgtat tttgcatgac acattttaaa aataataaac     2340

actattttta gaat                                                       2354


<210>  6
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Thr Ala Val Ala Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser 
            20                  25                  30          


Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr 
        115                 120                 125             


Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  7
<211>  542
<212>  DNA
<213>  Homo sapiens

<400>  7
acagtggtga gctcttagct tcaccaggct catcaaagct gctccaggaa ggcccaagcc       60

agaccagaag acatgcagat catcaccaca gccctggtgt gcttgctgct agctgggatg      120

tggccggaag atgtggacag caagagcatg caggtaccct tctccagatg ttgcttctca      180

tttgcggagc aagagattcc cctgagggca atcctgtgtt acagaaatac cagctccatc      240

tgctccaatg agggcttaat attcaagctg aagagaggca aagaggcctg cgccttggac      300

acagttggat gggttcagag gcacagaaaa atgctgaggc actgcccgtc aaaaagaaaa      360

tgagcagatt tctttccatt gtgggctctg gaaaccacat ggcttcacct gtccccgaaa      420

ctaccagccc tacaccattc cttctgccct gcttttgcta ggtcacagag gatctgcttg      480

gtcttgataa gctatgttgt tgcactttaa acatttaaat tatacaatca tcaaccccca      540

ac                                                                     542


<210>  8
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Ile Ile Thr Thr Ala Leu Val Cys Leu Leu Leu Ala Gly Met 
1               5                   10                  15      


Trp Pro Glu Asp Val Asp Ser Lys Ser Met Gln Val Pro Phe Ser Arg 
            20                  25                  30          


Cys Cys Phe Ser Phe Ala Glu Gln Glu Ile Pro Leu Arg Ala Ile Leu 
        35                  40                  45              


Cys Tyr Arg Asn Thr Ser Ser Ile Cys Ser Asn Glu Gly Leu Ile Phe 
    50                  55                  60                  


Lys Leu Lys Arg Gly Lys Glu Ala Cys Ala Leu Asp Thr Val Gly Trp 
65                  70                  75                  80  


Val Gln Arg His Arg Lys Met Leu Arg His Cys Pro Ser Lys Arg Lys 
                85                  90                  95      


<210>  9
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  9
atggcaggcc tgatgaccat agtaaccagc cttctgttcc ttggtgtctg tgcccaccac       60

atcatcccta cgggctctgt ggtcatcccc tctccctgct gcatgttctt tgtttccaag      120

agaattcctg agaaccgagt ggtcagctac cagctgtcca gcaggagcac atgcctcaag      180

gcaggagtga tcttcaccac caagaagggc cagcagttct gtggcgaccc caagcaggag      240

tgggtccaga ggtacatgaa gaacctggac gccaagcaga agaaggcttc ccctagggcc      300

agggcagtgg ctgtcaaggg ccctgtccag agatatcctg gcaaccaaac cacctgctaa      360


<210>  10
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Gly Leu Met Thr Ile Val Thr Ser Leu Leu Phe Leu Gly Val 
1               5                   10                  15      


Cys Ala His His Ile Ile Pro Thr Gly Ser Val Val Ile Pro Ser Pro 
            20                  25                  30          


Cys Cys Met Phe Phe Val Ser Lys Arg Ile Pro Glu Asn Arg Val Val 
        35                  40                  45              


Ser Tyr Gln Leu Ser Ser Arg Ser Thr Cys Leu Lys Ala Gly Val Ile 
    50                  55                  60                  


Phe Thr Thr Lys Lys Gly Gln Gln Phe Cys Gly Asp Pro Lys Gln Glu 
65                  70                  75                  80  


Trp Val Gln Arg Tyr Met Lys Asn Leu Asp Ala Lys Gln Lys Lys Ala 
                85                  90                  95      


Ser Pro Arg Ala Arg Ala Val Ala Val Lys Gly Pro Val Gln Arg Tyr 
            100                 105                 110         


Pro Gly Asn Gln Thr Thr Cys 
        115                 


<210>  11
<211>  2809
<212>  DNA
<213>  Homo sapiens

<400>  11
acgcgcgccc tgcggagccc gcccaactcc ggcgagccgg gcctgcgcct actcctcctc       60

ctcctctccc ggcggcggct gcggcggagg cgccgactcg gccttgcgcc cgccctcagg      120

cccgcgcggg cggcgcagcg aggccccggg cggcgggtgg tggctgccag gcggctcggc      180

cgcgggcgct gcccggcccc ggcgagcgga gggcggagcg cggcgccgga gccgagggcg      240

cgccgcggag ggggtgctgg gccgcgctgt gcccggccgg gcggcggctg caagaggagg      300

ccggaggcga gcgcggggcc ggcggtgggc gcgcagggcg gctcgcagct cgcagccggg      360

gccgggccag gcgtccaggc aggtgatcgg tgtggcggcg gcggcggcgg cggccccaga      420

ctccctccgg agttcttctt ggggctgatg tccgcaaata tgcagaatta ccggccgggt      480

cgctcctgaa gccagcgcgg ggagcgagcg cggcggcggc cagcaccggg aacgcaccga      540

ggaagaagcc cagcccccgc cctccgcccc ttccgtcccc accccctacc cggcggccca      600

ggaggctccc cgcgctgcgg gcgcgcactc cctgtttctc ctcctcctgg ctggcgctgc      660

ctgcctctcc gcactcactg ctcgcgccgg gcgcgctccg ccagctccgt gctccccgcg      720

ccaccctcct ccgggccgcg ctccctaagg gatggtactg aatttcgccg ccacaggaga      780

ccggctggag cgcccgcccc gcggcctcgc ctctcctccg agcagccagc gcctcgggac      840

gcgatgagga ccttggcttg cctgctgctc ctcggctgcg gatacctcgc ccatgttctg      900

gccgaggaag ccgagatccc ccgcgaggtg atcgagaggc tggcccgcag tcagatccac      960

agcatccggg acctccagcg actcctggag atagactccg tagggagtga ggattctttg     1020

gacaccagcc tgagagctca cggggtccat gccactaagc atgtgcccga gaagcggccc     1080

ctgcccattc ggaggaagag aagcatcgag gaagctgtcc ccgctgtctg caagaccagg     1140

acggtcattt acgagattcc tcggagtcag gtcgacccca cgtccgccaa cttcctgatc     1200

tggcccccgt gcgtggaggt gaaacgctgc accggctgct gcaacacgag cagtgtcaag     1260

tgccagccct cccgcgtcca ccaccgcagc gtcaaggtgg ccaaggtgga atacgtcagg     1320

aagaagccaa aattaaaaga agtccaggtg aggttagagg agcatttgga gtgcgcctgc     1380

gcgaccacaa gcctgaatcc ggattatcgg gaagaggaca cgggaaggcc tagggagtca     1440

ggtaaaaaac ggaaaagaaa aaggttaaaa cccacctaaa gcagccaacc agatgtgagg     1500

tgaggatgag ccgcagccct ttcctgggac atggatgtac atggcgtgtt acattcctga     1560

acctactatg tacggtgctt tattgccagt gtgcggtctt tgttctcctc cgtgaaaaac     1620

tgtgtccgag aacactcggg agaacaaaga gacagtgcac atttgtttaa tgtgacatca     1680

aagcaagtat tgtagcactc ggtgaagcag taagaagctt ccttgtcaaa aagagagaga     1740

gagaaagaga gagagaaaac aaaaccacaa atgacaaaaa caaaacggac tcacaaaaat     1800

atctaaactc gatgagatgg agggtcgccc cgtgggatgg aagtgcagag gtctcagcag     1860

actggatttc tgtccgggtg gtcacaggtg cttttttgcc gaggatgcag agcctgcttt     1920

gggaacgact ccagaggggt gctggtgggc tctgcagggg cccgcaggaa gcaggaatgt     1980

cttggaaacc gccacgcgaa ctttagaaac cacacctcct cgctgtagta tttaagccca     2040

tacagaaacc ttcctgagag ccttaagtgg tttttttttt tgtttttgtt ttgttttttt     2100

tttttttgtt tttttttttt tttttttaca ccataaagtg attattaagc tttccttttt     2160

actctttggc tagctttttt tttttttttt tttttttaat tatctcttgg atgacattta     2220

caccgataac acacaggctg ctgtaactgt caggacagtg cgacggtatt tttcctagca     2280

agatgcaaac taatgagatg tattaaaata aacatggtat acctacctat gcatcatttc     2340

ctaaatgttt ctggctttgt gtttctccct taccctgctt tatttgttaa tttaagccat     2400

tttgaaagaa ctatgcgtca accaatcgta cgccgtccct gcggcacctg ccccagagcc     2460

cgtttgtggc tgagtgacaa cttgttcccc gcagtgcaca cctagaatgc tgtgttccca     2520

cgcggcacgt gagatgcatt gccgcttctg tctgtgttgt tggtgtgccc tggtgccgtg     2580

gtggcggtca ctccctctgc tgccagtgtt tggacagaac ccaaattctt tatttttggt     2640

aagatattgt gctttacctg tattaacaga aatgtgtgtg tgtggtttgt ttttttgtaa     2700

aggtgaagtt tgtatgttta cctaatatta cctgttttgt atacctgaga gcctgctatg     2760

ttcttttttt gttgatccaa aattaaaaaa aaaaatacca ccaacaaaa                 2809


<210>  12
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
        195                 200                 205             


Lys Pro Thr 
    210     


<210>  13
<211>  2258
<212>  DNA
<213>  Homo sapiens

<400>  13
ctcctccagc tcttcctgtc ccgctgttgc aacactgcct cactcttccc ctcccacctt       60

ctctcccctc ctctctgctt taattttctc agaattctct ggactgaggc tccagttctg      120

gcctttgggg ttcaagatca ctgggaccag gccgtgatct ctatgcccga gtctcaaccc      180

tcaactgtca ccccaaggca cttgggacgt cctggacaga ccgagtcccg ggaagcccca      240

gcactgccgc tgccacactg ccctgagccc aaatggggga gtgagaggcc atagctgtct      300

ggcatgggcc tctccaccgt gcctgacctg ctgctgccac tggtgctcct ggagctgttg      360

gtgggaatat acccctcagg ggttattgga ctggtccctc acctagggga cagggagaag      420

agagatagtg tgtgtcccca aggaaaatat atccaccctc aaaataattc gatttgctgt      480

accaagtgcc acaaaggaac ctacttgtac aatgactgtc caggcccggg gcaggatacg      540

gactgcaggg agtgtgagag cggctccttc accgcttcag aaaaccacct cagacactgc      600

ctcagctgct ccaaatgccg aaaggaaatg ggtcaggtgg agatctcttc ttgcacagtg      660

gaccgggaca ccgtgtgtgg ctgcaggaag aaccagtacc ggcattattg gagtgaaaac      720

cttttccagt gcttcaattg cagcctctgc ctcaatggga ccgtgcacct ctcctgccag      780

gagaaacaga acaccgtgtg cacctgccat gcaggtttct ttctaagaga aaacgagtgt      840

gtctcctgta gtaactgtaa gaaaagcctg gagtgcacga agttgtgcct accccagatt      900

gagaatgtta agggcactga ggactcaggc accacagtgc tgttgcccct ggtcattttc      960

tttggtcttt gccttttatc cctcctcttc attggtttaa tgtatcgcta ccaacggtgg     1020

aagtccaagc tctactccat tgtttgtggg aaatcgacac ctgaaaaaga gggggagctt     1080

gaaggaacta ctactaagcc cctggcccca aacccaagct tcagtcccac tccaggcttc     1140

acccccaccc tgggcttcag tcccgtgccc agttccacct tcacctccag ctccacctat     1200

acccccggtg actgtcccaa ctttgcggct ccccgcagag aggtggcacc accctatcag     1260

ggggctgacc ccatccttgc gacagccctc gcctccgacc ccatccccaa cccccttcag     1320

aagtgggagg acagcgccca caagccacag agcctagaca ctgatgaccc cgcgacgctg     1380

tacgccgtgg tggagaacgt gcccccgttg cgctggaagg aattcgtgcg gcgcctaggg     1440

ctgagcgacc acgagatcga tcggctggag ctgcagaacg ggcgctgcct gcgcgaggcg     1500

caatacagca tgctggcgac ctggaggcgg cgcacgccgc ggcgcgaggc cacgctggag     1560

ctgctgggac gcgtgctccg cgacatggac ctgctgggct gcctggagga catcgaggag     1620

gcgctttgcg gccccgccgc cctcccgccc gcgcccagtc ttctcagatg aggctgcgcc     1680

cctgcgggca gctctaagga ccgtcctgcg agatcgcctt ccaaccccac ttttttctgg     1740

aaaggagggg tcctgcaggg gcaagcagga gctagcagcc gcctacttgg tgctaacccc     1800

tcgatgtaca tagcttttct cagctgcctg cgcgccgccg acagtcagcg ctgtgcgcgc     1860

ggagagaggt gcgccgtggg ctcaagagcc tgagtgggtg gtttgcgagg atgagggacg     1920

ctatgcctca tgcccgtttt gggtgtcctc accagcaagg ctgctcgggg gcccctggtt     1980

cgtccctgag cctttttcac agtgcataag cagttttttt tgtttttgtt ttgttttgtt     2040

ttgtttttaa atcaatcatg ttacactaat agaaacttgg cactcctgtg ccctctgcct     2100

ggacaagcac atagcaagct gaactgtcct aaggcagggg cgagcacgga acaatggggc     2160

cttcagctgg agctgtggac ttttgtacat acactaaaat tctgaagtta aagctctgct     2220

cttggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             2258


<210>  14
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  15
<211>  3682
<212>  DNA
<213>  Homo sapiens

<400>  15
gcgagcgcag cggagcctgg agagaaggcg ctgggctgcg agggcgcgag ggcgcgaggg       60

cagggggcaa ccggaccccg cccgcaccca tggcgcccgt cgccgtctgg gccgcgctgg      120

ccgtcggact ggagctctgg gctgcggcgc acgccttgcc cgcccaggtg gcatttacac      180

cctacgcccc ggagcccggg agcacatgcc ggctcagaga atactatgac cagacagctc      240

agatgtgctg cagcaaatgc tcgccgggcc aacatgcaaa agtcttctgt accaagacct      300

cggacaccgt gtgtgactcc tgtgaggaca gcacatacac ccagctctgg aactgggttc      360

ccgagtgctt gagctgtggc tcccgctgta gctctgacca ggtggaaact caagcctgca      420

ctcgggaaca gaaccgcatc tgcacctgca ggcccggctg gtactgcgcg ctgagcaagc      480

aggaggggtg ccggctgtgc gcgccgctgc gcaagtgccg cccgggcttc ggcgtggcca      540

gaccaggaac tgaaacatca gacgtggtgt gcaagccctg tgccccgggg acgttctcca      600

acacgacttc atccacggat atttgcaggc cccaccagat ctgtaacgtg gtggccatcc      660

ctgggaatgc aagcatggat gcagtctgca cgtccacgtc ccccacccgg agtatggccc      720

caggggcagt acacttaccc cagccagtgt ccacacgatc ccaacacacg cagccaactc      780

cagaacccag cactgctcca agcacctcct tcctgctccc aatgggcccc agccccccag      840

ctgaagggag cactggcgac ttcgctcttc cagttggact gattgtgggt gtgacagcct      900

tgggtctact aataatagga gtggtgaact gtgtcatcat gacccaggtg aaaaagaagc      960

ccttgtgcct gcagagagaa gccaaggtgc ctcacttgcc tgccgataag gcccggggta     1020

cacagggccc cgagcagcag cacctgctga tcacagcgcc gagctccagc agcagctccc     1080

tggagagctc ggccagtgcg ttggacagaa gggcgcccac tcggaaccag ccacaggcac     1140

caggcgtgga ggccagtggg gccggggagg cccgggccag caccgggagc tcagattctt     1200

cccctggtgg ccatgggacc caggtcaatg tcacctgcat cgtgaacgtc tgtagcagct     1260

ctgaccacag ctcacagtgc tcctcccaag ccagctccac aatgggagac acagattcca     1320

gcccctcgga gtccccgaag gacgagcagg tccccttctc caaggaggaa tgtgcctttc     1380

ggtcacagct ggagacgcca gagaccctgc tggggagcac cgaagagaag cccctgcccc     1440

ttggagtgcc tgatgctggg atgaagccca gttaaccagg ccggtgtggg ctgtgtcgta     1500

gccaaggtgg gctgagccct ggcaggatga ccctgcgaag gggccctggt ccttccaggc     1560

ccccaccact aggactctga ggctctttct gggccaagtt cctctagtgc cctccacagc     1620

cgcagcctcc ctctgacctg caggccaaga gcagaggcag cgagttgtgg aaagcctctg     1680

ctgccatggc gtgtccctct cggaaggctg gctgggcatg gacgttcggg gcatgctggg     1740

gcaagtccct gactctctgt gacctgcccc gcccagctgc acctgccagc ctggcttctg     1800

gagcccttgg gttttttgtt tgtttgtttg tttgtttgtt tgtttctccc cctgggctct     1860

gccccagctc tggcttccag aaaaccccag catccttttc tgcagagggg ctttctggag     1920

aggagggatg ctgcctgagt cacccatgaa gacaggacag tgcttcagcc tgaggctgag     1980

actgcgggat ggtcctgggg ctctgtgcag ggaggaggtg gcagccctgt agggaacggg     2040

gtccttcaag ttagctcagg aggcttggaa agcatcacct caggccaggt gcagtggctc     2100

acgcctatga tcccagcact ttgggaggct gaggcgggtg gatcacctga ggttaggagt     2160

tcgagaccag cctggccaac atggtaaaac cccatctcta ctaaaaatac agaaattagc     2220

cgggcgtggt ggcgggcacc tatagtccca gctactcaga agcctgaggc tgggaaatcg     2280

tttgaacccg ggaagcggag gttgcaggga gccgagatca cgccactgca ctccagcctg     2340

ggcgacagag cgagagtctg tctcaaaaga aaaaaaaaag caccgcctcc aaatgccaac     2400

ttgtcctttt gtaccatggt gtgaaagtca gatgcccaga gggcccaggc aggccaccat     2460

attcagtgct gtggcctggg caagataacg cacttctaac tagaaatctg ccaatttttt     2520

aaaaaagtaa gtaccactca ggccaacaag ccaacgacaa agccaaactc tgccagccac     2580

atccaacccc ccacctgcca tttgcaccct ccgccttcac tccggtgtgc ctgcagcccc     2640

gcgcctcctt ccttgctgtc ctaggccaca ccatctcctt tcagggaatt tcaggaacta     2700

gagatgactg agtcctcgta gccatctctc tactcctacc tcagcctaga ccctcctcct     2760

cccccagagg ggtgggttcc tcttccccac tccccacctt caattcctgg gccccaaacg     2820

ggctgccctg ccactttggt acatggccag tgtgatccca agtgccagtc ttgtgtctgc     2880

gtctgtgttg cgtgtcgtgg gtgtgtgtag ccaaggtcgg taagttgaat ggcctgcctt     2940

gaagccactg aagctgggat tcctccccat tagagtcagc cttccccctc ccagggccag     3000

ggccctgcag aggggaaacc agtgtagcct tgcccggatt ctgggaggaa gcaggttgag     3060

gggctcctgg aaaggctcag tctcaggagc atggggataa aggagaaggc atgaaattgt     3120

ctagcagagc aggggcaggg tgataaattg ttgataaatt ccactggact tgagcttggc     3180

agctgaacta ttggagggtg ggagagccca gccattacca tggagacaag aagggttttc     3240

caccctggaa tcaagatgtc agactggctg gctgcagtga cgtgcacctg tactcaggag     3300

gctgagggga ggatcactgg agcccaggag tttgaggctg cagcgagcta tgatcgcgcc     3360

actacactcc agcctgagca acagagtgag accctgtctc ttaaagaaaa aaaaagtcag     3420

actgctggga ctggccaggt ttctgcccac attggaccca catgaggaca tgatggagcg     3480

cacctgcccc ctggtggaca gtcctgggag aacctcaggc ttccttggca tcacagggca     3540

gagccgggaa gcgatgaatt tggagactct gtggggcctt ggttcccttg tgtgtgtgtg     3600

ttgatcccaa gacaatgaaa gtttgcactg tatgctggac ggcattcctg cttatcaata     3660

aacctgtttg ttttaaaaaa aa                                              3682


<210>  16
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  17
<211>  5600
<212>  DNA
<213>  Homo sapiens

<400>  17
aaaaagagaa actgttggga gaggaatcgt atctccatat ttcttctttc agccccaatc       60

caagggttgt agctggaact ttccatcagt tcttcctttc tttttcctct ctaagccttt      120

gccttgctct gtcacagtga agtcagccag agcagggctg ttaaactctg tgaaatttgt      180

cataagggtg tcaggtattt cttactggct tccaaagaaa catagataaa gaaatctttc      240

ctgtggcttc ccttggcagg ctgcattcag aaggtctctc agttgaagaa agagcttgga      300

ggacaacagc acaacaggag agtaaaagat gccccagggc tgaggcctcc gctcaggcag      360

ccgcatctgg ggtcaatcat actcaccttg cccgggccat gctccagcaa aatcaagctg      420

ttttcttttg aaagttcaaa ctcatcaaga ttatgctgct cactcttatc attctgttgc      480

cagtagtttc aaaatttagt tttgttagtc tctcagcacc gcagcactgg agctgtcctg      540

aaggtactct cgcaggaaat gggaattcta cttgtgtggg tcctgcaccc ttcttaattt      600

tctcccatgg aaatagtatc tttaggattg acacagaagg aaccaattat gagcaattgg      660

tggtggatgc tggtgtctca gtgatcatgg attttcatta taatgagaaa agaatctatt      720

gggtggattt agaaagacaa cttttgcaaa gagtttttct gaatgggtca aggcaagaga      780

gagtatgtaa tatagagaaa aatgtttctg gaatggcaat aaattggata aatgaagaag      840

ttatttggtc aaatcaacag gaaggaatca ttacagtaac agatatgaaa ggaaataatt      900

cccacattct tttaagtgct ttaaaatatc ctgcaaatgt agcagttgat ccagtagaaa      960

ggtttatatt ttggtcttca gaggtggctg gaagccttta tagagcagat ctcgatggtg     1020

tgggagtgaa ggctctgttg gagacatcag agaaaataac agctgtgtca ttggatgtgc     1080

ttgataagcg gctgttttgg attcagtaca acagagaagg aagcaattct cttatttgct     1140

cctgtgatta tgatggaggt tctgtccaca ttagtaaaca tccaacacag cataatttgt     1200

ttgcaatgtc cctttttggt gaccgtatct tctattcaac atggaaaatg aagacaattt     1260

ggatagccaa caaacacact ggaaaggaca tggttagaat taacctccat tcatcatttg     1320

taccacttgg tgaactgaaa gtagtgcatc cacttgcaca acccaaggca gaagatgaca     1380

cttgggagcc tgagcagaaa ctttgcaaat tgaggaaagg aaactgcagc agcactgtgt     1440

gtgggcaaga cctccagtca cacttgtgca tgtgtgcaga gggatacgcc ctaagtcgag     1500

accggaagta ctgtgaagat gttaatgaat gtgctttttg gaatcatggc tgtactcttg     1560

ggtgtaaaaa cacccctgga tcctattact gcacgtgccc tgtaggattt gttctgcttc     1620

ctgatgggaa acgatgtcat caacttgttt cctgtccacg caatgtgtct gaatgcagcc     1680

atgactgtgt tctgacatca gaaggtccct tatgtttctg tcctgaaggc tcagtgcttg     1740

agagagatgg gaaaacatgt agcggttgtt cctcacccga taatggtgga tgtagccagc     1800

tctgcgttcc tcttagccca gtatcctggg aatgtgattg ctttcctggg tatgacctac     1860

aactggatga aaaaagctgt gcagcttcag gaccacaacc atttttgctg tttgccaatt     1920

ctcaagatat tcgacacatg cattttgatg gaacagacta tggaactctg ctcagccagc     1980

agatgggaat ggtttatgcc ctagatcatg accctgtgga aaataagata tactttgccc     2040

atacagccct gaagtggata gagagagcta atatggatgg ttcccagcga gaaaggctta     2100

ttgaggaagg agtagatgtg ccagaaggtc ttgctgtgga ctggattggc cgtagattct     2160

attggacaga cagagggaaa tctctgattg gaaggagtga tttaaatggg aaacgttcca     2220

aaataatcac taaggagaac atctctcaac cacgaggaat tgctgttcat ccaatggcca     2280

agagattatt ctggactgat acagggatta atccacgaat tgaaagttct tccctccaag     2340

gccttggccg tctggttata gccagctctg atctaatctg gcccagtgga ataacgattg     2400

acttcttaac tgacaagttg tactggtgcg atgccaagca gtctgtgatt gaaatggcca     2460

atctggatgg ttcaaaacgc cgaagactta cccagaatga tgtaggtcac ccatttgctg     2520

tagcagtgtt tgaggattat gtgtggttct cagattgggc tatgccatca gtaatgagag     2580

taaacaagag gactggcaaa gatagagtac gtctccaagg cagcatgctg aagccctcat     2640

cactggttgt ggttcatcca ttggcaaaac caggagcaga tccctgctta tatcaaaacg     2700

gaggctgtga acatatttgc aaaaagaggc ttggaactgc ttggtgttcg tgtcgtgaag     2760

gttttatgaa agcctcagat gggaaaacgt gtctggctct ggatggtcat cagctgttgg     2820

caggtggtga agttgatcta aagaaccaag taacaccatt ggacatcttg tccaagacta     2880

gagtgtcaga agataacatt acagaatctc aacacatgct agtggctgaa atcatggtgt     2940

cagatcaaga tgactgtgct cctgtgggat gcagcatgta tgctcggtgt atttcagagg     3000

gagaggatgc cacatgtcag tgtttgaaag gatttgctgg ggatggaaaa ctatgttctg     3060

atatagatga atgtgagatg ggtgtcccag tgtgcccccc tgcctcctcc aagtgcatca     3120

acaccgaagg tggttatgtc tgccggtgct cagaaggcta ccaaggagat gggattcact     3180

gtcttgatat tgatgagtgc caactggggg agcacagctg tggagagaat gccagctgca     3240

caaatacaga gggaggctat acctgcatgt gtgctggacg cctgtctgaa ccaggactga     3300

tttgccctga ctctactcca ccccctcacc tcagggaaga tgaccaccac tattccgtaa     3360

gaaatagtga ctctgaatgt cccctgtccc acgatgggta ctgcctccat gatggtgtgt     3420

gcatgtatat tgaagcattg gacaagtatg catgcaactg tgttgttggc tacatcgggg     3480

agcgatgtca gtaccgagac ctgaagtggt gggaactgcg ccacgctggc cacgggcagc     3540

agcagaaggt catcgtggtg gctgtctgcg tggtggtgct tgtcatgctg ctcctcctga     3600

gcctgtgggg ggcccactac tacaggactc agaagctgct atcgaaaaac ccaaagaatc     3660

cttatgagga gtcgagcaga gatgtgagga gtcgcaggcc tgctgacact gaggatggga     3720

tgtcctcttg ccctcaacct tggtttgtgg ttataaaaga acaccaagac ctcaagaatg     3780

ggggtcaacc agtggctggt gaggatggcc aggcagcaga tgggtcaatg caaccaactt     3840

catggaggca ggagccccag ttatgtggaa tgggcacaga gcaaggctgc tggattccag     3900

tatccagtga taagggctcc tgtccccagg taatggagcg aagctttcat atgccctcct     3960

atgggacaca gacccttgaa gggggtgtcg agaagcccca ttctctccta tcagctaacc     4020

cattatggca acaaagggcc ctggacccac cacaccaaat ggagctgact cagtgaaaac     4080

tggaattaaa aggaaagtca agaagaatga actatgtcga tgcacagtat cttttctttc     4140

aaaagtagag caaaactata ggttttggtt ccacaatctc tacgactaat cacctactca     4200

atgcctggag acagatacgt agttgtgctt ttgtttgctc ttttaagcag tctcactgca     4260

gtcttatttc caagtaagag tactgggaga atcactaggt aacttattag aaacccaaat     4320

tgggacaaca gtgctttgta aattgtgttg tcttcagcag tcaatacaaa tagatttttg     4380

tttttgttgt tcctgcagcc ccagaagaaa ttaggggtta aagcagacag tcacactggt     4440

ttggtcagtt acaaagtaat ttctttgatc tggacagaac atttatatca gtttcatgaa     4500

atgattggaa tattacaata ccgttaagat acagtgtagg catttaactc ctcattggcg     4560

tggtccatgc tgatgatttt gcaaaatgag ttgtgatgaa tcaatgaaaa atgtaattta     4620

gaaactgatt tcttcagaat tagatggctt attttttaaa atatttgaat gaaaacattt     4680

tatttttaaa atattacaca ggaggcttcg gagtttctta gtcattactg tccttttccc     4740

ctacagaatt ttccctcttg gtgtgattgc acagaatttg tatgtatttt cagttacaag     4800

attgtaagta aattgcctga tttgttttca ttatagacaa cgatgaattt cttctaatta     4860

tttaaataaa atcaccaaaa acataaacat tttattgtat gcctgattaa gtagttaatt     4920

atagtctaag gcagtactag agttgaacca aaatgatttg tcaagcttgc tgatgtttct     4980

gtttttcgtt tttttttttt ttccggagag aggataggat ctcactctgt tatccaggct     5040

ggagtgtgca atggcacaat catagctcag tgcagcctca aactcctggg ctcaagcaat     5100

cctcctgcct cagcctcccg agtaactagg accacaggca caggccacca tgcctggcta     5160

aggtttttat ttttattttt tgtagacatg gggatcacac aatgttgccc aggctggtct     5220

tgaactcctg gcctcaagca aggtcgtgct ggtaattttg caaaatgaat tgtgattgac     5280

tttcagcctc ccaacgtatt agattatagg cattagccat ggtgcccagc cttgtaactt     5340

ttaaaaaaat tttttaatct acaactctgt agattaaaat ttcacatggt gttctaatta     5400

aatatttttc ttgcagccaa gatattgtta ctacagataa cacaacctga tatggtaact     5460

ttaaattttg ggggctttga atcattcagt ttatgcatta actagtccct ttgtttatct     5520

ttcatttctc aaccccttgt actttggtga taccagacat cagaataaaa agaaattgaa     5580

gtaaaaaaaa aaaaaaaaaa                                                 5600


<210>  18
<211>  1207
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         


<210>  19
<211>  667
<212>  DNA
<213>  Homo sapiens

<400>  19
agcacaggac acagctgggt tctgaagctt ctgagttctg cagcctcacc tctgagaaaa       60

cctctttgcc accaatacca tgaagctctg cgtgactgtc ctgtctctcc tcatgctagt      120

agctgccttc tgctctccag cgctctcagc accaatgggc tcagaccctc ccaccgcctg      180

ctgcttttct tacactgcga ggaagcttcc tcgcaacttt gtggtagatt actatgagac      240

cagcagcctc tgctcccagc cagctgtggt attccaaacc aaaagaagca agcaagtctg      300

tgctgatccc agtgaatcct gggtccagga gtacgtgtat gacctggaac tgaactgagc      360

tgctcagaga caggaagtct tcagggaagg tcacctgagc ccggatgctt ctccatgaga      420

cacatctcct ccatactcag gactcctctc cgcagttcct gtcccttctc ttaatttaat      480

cttttttatg tgccgtgtta ttgtattagg tgtcatttcc attatttata ttagtttagc      540

caaaggataa gtgtccccta tggggatggt ccactgtcac tgtttctctg ctgttgcaaa      600

tacatggata acacatttga ttctgtgtgt tttcataata aaactttaaa ataaaatgca      660

gacagtt                                                                667


<210>  20
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  21
<211>  2545
<212>  DNA
<213>  Homo sapiens

<400>  21
atccaataca ggagtgactt ggaactccat tctatcacta tgaagaaaag tggtgttctt       60

ttcctcttgg gcatcatctt gctggttctg attggagtgc aaggaacccc agtagtgaga      120

aagggtcgct gttcctgcat cagcaccaac caagggacta tccacctaca atccttgaaa      180

gaccttaaac aatttgcccc aagcccttcc tgcgagaaaa ttgaaatcat tgctacactg      240

aagaatggag ttcaaacatg tctaaaccca gattcagcag atgtgaagga actgattaaa      300

aagtgggaga aacaggtcag ccaaaagaaa aagcaaaaga atgggaaaaa acatcaaaaa      360

aagaaagttc tgaaagttcg aaaatctcaa cgttctcgtc aaaagaagac tacataagag      420

accacttcac caataagtat tctgtgttaa aaatgttcta ttttaattat accgctatca      480

ttccaaagga ggatggcata taatacaaag gcttattaat ttgactagaa aatttaaaac      540

attactctga aattgtaact aaagttagaa agttgatttt aagaatccaa acgttaagaa      600

ttgttaaagg ctatgattgt ctttgttctt ctaccaccca ccagttgaat ttcatcatgc      660

ttaaggccat gattttagca atacccatgt ctacacagat gttcacccaa ccacatccca      720

ctcacaacag ctgcctggaa gagcagccct aggcttccac gtactgcagc ctccagagag      780

tatctgaggc acatgtcagc aagtcctaag cctgttagca tgctggtgag ccaagcagtt      840

tgaaattgag ctggacctca ccaagctgct gtggccatca acctctgtat ttgaatcagc      900

ctacaggcct cacacacaat gtgtctgaga gattcatgct gattgttatt gggtatcacc      960

actggagatc accagtgtgt ggctttcaga gcctcctttc tggctttgga agccatgtga     1020

ttccatcttg cccgctcagg ctgaccactt tatttctttt tgttcccctt tgcttcattc     1080

aagtcagctc ttctccatcc taccacaatg cagtgccttt cttctctcca gtgcacctgt     1140

catatgctct gatttatctg agtcaactcc tttctcatct tgtccccaac accccacaga     1200

agtgctttct tctcccaatt catcctcact cagtccagct tagttcaagt cctgcctctt     1260

aaataaacct ttttggacac acaaattatc ttaaaactcc tgtttcactt ggttcagtac     1320

cacatgggtg aacactcaat ggttaactaa ttcttgggtg tttatcctat ctctccaacc     1380

agattgtcag ctccttgagg gcaagagcca cagtatattt ccctgtttct tccacagtgc     1440

ctaataatac tgtggaacta ggttttaata attttttaat tgatgttgtt atgggcagga     1500

tggcaaccag accattgtct cagagcaggt gctggctctt tcctggctac tccatgttgg     1560

ctagcctctg gtaacctctt acttattatc ttcaggacac tcactacagg gaccagggat     1620

gatgcaacat ccttgtcttt ttatgacagg atgtttgctc agcttctcca acaataagaa     1680

gcacgtggta aaacacttgc ggatattctg gactgttttt aaaaaatata cagtttaccg     1740

aaaatcatat aatcttacaa tgaaaaggac tttatagatc agccagtgac caaccttttc     1800

ccaaccatac aaaaattcct tttcccgaag gaaaagggct ttctcaataa gcctcagctt     1860

tctaagatct aacaagatag ccaccgagat ccttatcgaa actcatttta ggcaaatatg     1920

agttttattg tccgtttact tgtttcagag tttgtattgt gattatcaat taccacacca     1980

tctcccatga agaaagggaa cggtgaagta ctaagcgcta gaggaagcag ccaagtcggt     2040

tagtggaagc atgattggtg cccagttagc ctctgcagga tgtggaaacc tccttccagg     2100

ggaggttcag tgaattgtgt aggagaggtt gtctgtggcc agaatttaaa cctatactca     2160

ctttcccaaa ttgaatcact gctcacactg ctgatgattt agagtgctgt ccggtggaga     2220

tcccacccga acgtcttatc taatcatgaa actccctagt tccttcatgt aacttccctg     2280

aaaaatctaa gtgtttcata aatttgagag tctgtgaccc acttaccttg catctcacag     2340

gtagacagta tataactaac aaccaaagac tacatattgt cactgacaca cacgttataa     2400

tcatttatca tatatataca tacatgcata cactctcaaa gcaaataatt tttcacttca     2460

aaacagtatt gacttgtata ccttgtaatt tgaaatattt tctttgttaa aatagaatgg     2520

tatcaataaa tagaccatta atcag                                           2545


<210>  22
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  23
<211>  760
<212>  DNA
<213>  Homo sapiens

<400>  23
gaggaaccga gaggctgaga ctaacccaga aacatccaat tctcaaactg aagctcgcac       60

tctcgcctcc agcatgaaag tctctgccgc ccttctgtgc ctgctgctca tagcagccac      120

cttcattccc caagggctcg ctcagccaga tgcaatcaat gccccagtca cctgctgtta      180

taacttcacc aataggaaga tctcagtgca gaggctcgcg agctatagaa gaatcaccag      240

cagcaagtgt cccaaagaag ctgtgatctt caagaccatt gtggccaagg agatctgtgc      300

tgaccccaag cagaagtggg ttcaggattc catggaccac ctggacaagc aaacccaaac      360

tccgaagact tgaacactca ctccacaacc caagaatctg cagctaactt attttcccct      420

agctttcccc agacaccctg ttttatttta ttataatgaa ttttgtttgt tgatgtgaaa      480

cattatgcct taagtaatgt taattcttat ttaagttatt gatgttttaa gtttatcttt      540

catggtacta gtgtttttta gatacagaga cttggggaaa ttgcttttcc tcttgaacca      600

cagttctacc cctgggatgt tttgagggtc tttgcaagaa tcattaatac aaagaatttt      660

ttttaacatt ccaatgcatt gctaaaatat tattgtggaa atgaatattt tgtaactatt      720

acaccaaata aatatatttt tgtacaaaaa aaaaaaaaaa                            760


<210>  24
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210>  25
<211>  1439
<212>  DNA
<213>  Homo sapiens

<400>  25
tgcggcggcg agggaggagg aagaagcgga ggaggcggct cccgcgctcg cagggccgtg       60

ccacctgccc gcccgcccgc tcgctcgctc gcccgccgcg ccgcgctgcc gaccgccagc      120

atgctgccga gagtgggctg ccccgcgctg ccgctgccgc cgccgccgct gctgccgctg      180

ctgccgctgc tgctgctgct actgggcgcg agtggcggcg gcggcggggc gcgcgcggag      240

gtgctgttcc gctgcccgcc ctgcacaccc gagcgcctgg ccgcctgcgg gcccccgccg      300

gttgcgccgc ccgccgcggt ggccgcagtg gccggaggcg cccgcatgcc atgcgcggag      360

ctcgtccggg agccgggctg cggctgctgc tcggtgtgcg cccggctgga gggcgaggcg      420

tgcggcgtct acaccccgcg ctgcggccag gggctgcgct gctatcccca cccgggctcc      480

gagctgcccc tgcaggcgct ggtcatgggc gagggcactt gtgagaagcg ccgggacgcc      540

gagtatggcg ccagcccgga gcaggttgca gacaatggcg atgaccactc agaaggaggc      600

ctggtggaga accacgtgga cagcaccatg aacatgttgg gcgggggagg cagtgctggc      660

cggaagcccc tcaagtcggg tatgaaggag ctggccgtgt tccgggagaa ggtcactgag      720

cagcaccggc agatgggcaa gggtggcaag catcaccttg gcctggagga gcccaagaag      780

ctgcgaccac cccctgccag gactccctgc caacaggaac tggaccaggt cctggagcgg      840

atctccacca tgcgccttcc ggatgagcgg ggccctctgg agcacctcta ctccctgcac      900

atccccaact gtgacaagca tggcctgtac aacctcaaac agtgcaagat gtctctgaac      960

gggcagcgtg gggagtgctg gtgtgtgaac cccaacaccg ggaagctgat ccagggagcc     1020

cccaccatcc ggggggaccc cgagtgtcat ctcttctaca atgagcagca ggaggctcgc     1080

ggggtgcaca cccagcggat gcagtagacc gcagccagcc ggtgcctggc gcccctgccc     1140

cccgcccctc tccaaacacc ggcagaaaac ggagagtgct tgggtggtgg gtgctggagg     1200

attttccagt tctgacacac gtatttatat ttggaaagag accagcaccg agctcggcac     1260

ctccccggcc tctctcttcc cagctgcaga tgccacacct gctccttctt gctttccccg     1320

ggggaggaag ggggttgtgg tcggggagct ggggtacagg tttggggagg gggaagagaa     1380

atttttattt ttgaacccct gtgtcccttt tgcataagat taaaggaagg aaaagtaaa      1439


<210>  26
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  27
<211>  1660
<212>  DNA
<213>  Homo sapiens

<400>  27
ggtgcactag caaaacaaac ttattttgaa cactcagctc ctagcgtgcg gcgctgccaa       60

tcattaacct cctggtgcaa gtggcgcggc ctgtgccctt tataaggtgc gcgctgtgtc      120

cagcgagcat cggccaccgc catcccatcc agcgagcatc tgccgccgcg ccgccgccac      180

cctcccagag agcactggcc accgctccac catcacttgc ccagagtttg ggccaccgcc      240

cgccgccacc agcccagaga gcatcggccc ctgtctgctg ctcgcgcctg gagatgtcag      300

aggtccccgt tgctcgcgtc tggctggtac tgctcctgct gactgtccag gtcggcgtga      360

cagccggcgc tccgtggcag tgcgcgccct gctccgccga gaagctcgcg ctctgcccgc      420

cggtgtccgc ctcgtgctcg gaggtcaccc ggtccgccgg ctgcggctgt tgcccgatgt      480

gcgccctgcc tctgggcgcc gcgtgcggcg tggcgactgc acgctgcgcc cggggactca      540

gttgccgcgc gctgccgggg gagcagcaac ctctgcacgc cctcacccgc ggccaaggcg      600

cctgcgtgca ggagtctgac gcctccgctc cccatgctgc agaggcaggg agccctgaaa      660

gcccagagag cacggagata actgaggagg agctcctgga taatttccat ctgatggccc      720

cttctgaaga ggatcattcc atcctttggg acgccatcag tacctatgat ggctcgaagg      780

ctctccatgt caccaacatc aaaaaatgga aggagccctg ccgaatagaa ctctacagag      840

tcgtagagag tttagccaag gcacaggaga catcaggaga agaaatttcc aaattttacc      900

tgccaaactg caacaagaat ggattttatc acagcagaca gtgtgagaca tccatggatg      960

gagaggcggg actctgctgg tgcgtctacc cttggaatgg gaagaggatc cctgggtctc     1020

cagagatcag gggagacccc aactgccaga tatattttaa tgtacaaaac tgaaaccaga     1080

tgaaataatg ttctgtcacg tgaaatattt aagtatatag tatatttata ctctagaaca     1140

tgcacattta tatatatatg tatatgtata tatatatagt aactactttt tatactccat     1200

acataacttg atatagaaag ctgtttattt attcactgta agtttatttt ttctacacag     1260

taaaaacttg tactatgtta ataacttgtc ctatgtcaat ttgtatatca tgaaacactt     1320

ctcatcatat tgtatgtaag taattgcatt tctgctcttc caaagctcct gcgtctgttt     1380

ttaaagagca tggaaaaata ctgcctagaa aatgcaaaat gaaataagag agagtagttt     1440

ttcagctagt ttgaaggagg acggttaact tgtatattcc accattcaca tttgatgtac     1500

atgtgtaggg aaagttaaaa gtgttgatta cataatcaaa gctacctgtg gtgatgttgc     1560

cacctgttaa aatgtacact ggatatgttg ttaaacacgt gtctataatg gaaacattta     1620

caataaatat tctgcatgga aatactgtta aaaaaaaaaa                           1660


<210>  28
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 
            20                  25                  30          


Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 
        35                  40                  45              


Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 
65                  70                  75                  80  


Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 
                85                  90                  95      


Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 
            100                 105                 110         


Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 
        115                 120                 125             


Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 
    130                 135                 140                 


Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 
145                 150                 155                 160 


Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 
                165                 170                 175     


Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 
            180                 185                 190         


Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 
        195                 200                 205             


Asn Gly Phe Tyr His Ser Arg Gln Cys Glu Thr Ser Met Asp Gly Glu 
    210                 215                 220                 


Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro 
225                 230                 235                 240 


Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn 
                245                 250                 255     


Val Gln Asn 
            


<210>  29
<211>  1220
<212>  DNA
<213>  Homo sapiens

<400>  29
agtcccagct cagagccgca acctgcacag ccatgcccgg gcaagaactc aggacggtga       60

atggctctca gatgctcctg gtgttgctgg tgctctcgtg gctgccgcat gggggcgccc      120

tgtctctggc cgaggcgagc cgcgcaagtt tcccgggacc ctcagagttg cactccgaag      180

actccagatt ccgagagttg cggaaacgct acgaggacct gctaaccagg ctgcgggcca      240

accagagctg ggaagattcg aacaccgacc tcgtcccggc ccctgcagtc cggatactca      300

cgccagaagt gcggctggga tccggcggcc acctgcacct gcgtatctct cgggccgccc      360

ttcccgaggg gctccccgag gcctcccgcc ttcaccgggc tctgttccgg ctgtccccga      420

cggcgtcaag gtcgtgggac gtgacacgac cgctgcggcg tcagctcagc cttgcaagac      480

cccaggcgcc cgcgctgcac ctgcgactgt cgccgccgcc gtcgcagtcg gaccaactgc      540

tggcagaatc ttcgtccgca cggccccagc tggagttgca cttgcggccg caagccgcca      600

gggggcgccg cagagcgcgt gcgcgcaacg gggaccactg tccgctcggg cccgggcgtt      660

gctgccgtct gcacacggtc cgcgcgtcgc tggaagacct gggctgggcc gattgggtgc      720

tgtcgccacg ggaggtgcaa gtgaccatgt gcatcggcgc gtgcccgagc cagttccggg      780

cggcaaacat gcacgcgcag atcaagacga gcctgcaccg cctgaagccc gacacggtgc      840

cagcgccctg ctgcgtgccc gccagctaca atcccatggt gctcattcaa aagaccgaca      900

ccggggtgtc gctccagacc tatgatgact tgttagccaa agactgccac tgcatatgag      960

cagtcctggt ccttccactg tgcacctgcg cggaggacgc gacctcagtt gtcctgccct     1020

gtggaatggg ctcaaggttc ctgagacacc cgattcctgc ccaaacagct gtatttatat     1080

aagtctgtta tttattatta atttattggg gtgaccttct tggggactcg ggggctggtc     1140

tgatggaact gtgtatttat ttaaaactct ggtgataaaa ataaagctgt ctgaactgtt     1200

aaaaaaaaaa aaaaaaaaaa                                                 1220


<210>  30
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  31
<211>  3677
<212>  DNA
<213>  Homo sapiens

<400>  31
tcgcggaggc ttggggcagc cgggtagctc ggaggtcgtg gcgctggggg ctagcaccag       60

cgctctgtcg ggaggcgcag cggttaggtg gaccggtcag cggactcacc ggccagggcg      120

ctcggtgctg gaatttgata ttcattgatc cgggttttat ccctcttctt ttttcttaaa      180

catttttttt taaaactgta ttgtttctcg ttttaattta tttttgcttg ccattcccca      240

cttgaatcgg gccgacggct tggggagatt gctctacttc cccaaatcac tgtggatttt      300

ggaaaccagc agaaagagga aagaggtagc aagagctcca gagagaagtc gaggaagaga      360

gagacggggt cagagagagc gcgcgggcgt gcgagcagcg aaagcgacag gggcaaagtg      420

agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc cttgggatcc      480

cgcagctgac cagtcgcgct gacggacaga cagacagaca ccgcccccag ccccagctac      540

cacctcctcc ccggccggcg gcggacagtg gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg ggtggagggg gtcggggctc gcggcgtcgc actgaaactt      660

ttcgtccaac ttctgggctg ttctcgcttc ggaggagccg tggtccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagtgctagc tcgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc agtggcgact cggcgctcgg      840

aagccgggct catggacggg tgaggcggcg gtgtgcgcag acagtgctcc agccgcgcgc      900

gctccccagg ccctggcccg ggcctcgggc cggggaggaa gagtagctcg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggtcgggcct ccgaaaccat gaactttctg ctgtcttggg tgcattggag ccttgccttg     1080

ctgctctacc tccaccatgc caagtggtcc caggctgcac ccatggcaga aggaggaggg     1140

cagaatcatc acgaagtggt gaagttcatg gatgtctatc agcgcagcta ctgccatcca     1200

atcgagaccc tggtggacat cttccaggag taccctgatg agatcgagta catcttcaag     1260

ccatcctgtg tgcccctgat gcgatgcggg ggctgctgca atgacgaggg cctggagtgt     1320

gtgcccactg aggagtccaa catcaccatg cagattatgc ggatcaaacc tcaccaaggc     1380

cagcacatag gagagatgag cttcctacag cacaacaaat gtgaatgcag accaaagaaa     1440

gatagagcaa gacaagaaaa aaaatcagtt cgaggaaagg gaaaggggca aaaacgaaag     1500

cgcaagaaat cccggtataa gtcctggagc gtgtacgttg gtgcccgctg ctgtctaatg     1560

ccctggagcc tccctggccc ccatccctgt gggccttgct cagagcggag aaagcatttg     1620

tttgtacaag atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag     1680

gcgaggcagc ttgagttaaa cgaacgtact tgcagatgtg acaagccgag gcggtgagcc     1740

gggcaggagg aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac     1800

tgatacagaa cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag     1860

aacagtcctt aatccagaaa cctgaaatga aggaagagga gactctgcgc agagcacttt     1920

gggtccggag ggcgagactc cggcggaagc attcccgggc gggtgaccca gcacggtccc     1980

tcttggaatt ggattcgcca ttttattttt cttgctgcta aatcaccgag cccggaagat     2040

tagagagttt tatttctggg attcctgtag acacacccac ccacatacat acatttatat     2100

atatatatat tatatatata taaaaataaa tatctctatt ttatatatat aaaatatata     2160

tattcttttt ttaaattaac agtgctaatg ttattggtgt cttcactgga tgtatttgac     2220

tgctgtggac ttgagttggg aggggaatgt tcccactcag atcctgacag ggaagaggag     2280

gagatgagag actctggcat gatctttttt ttgtcccact tggtggggcc agggtcctct     2340

cccctgccca ggaatgtgca aggccagggc atgggggcaa atatgaccca gttttgggaa     2400

caccgacaaa cccagccctg gcgctgagcc tctctacccc aggtcagacg gacagaaaga     2460

cagatcacag gtacagggat gaggacaccg gctctgacca ggagtttggg gagcttcagg     2520

acattgctgt gctttgggga ttccctccac atgctgcacg cgcatctcgc ccccaggggc     2580

actgcctgga agattcagga gcctgggcgg ccttcgctta ctctcacctg cttctgagtt     2640

gcccaggaga ccactggcag atgtcccggc gaagagaaga gacacattgt tggaagaagc     2700

agcccatgac agctcccctt cctgggactc gccctcatcc tcttcctgct ccccttcctg     2760

gggtgcagcc taaaaggacc tatgtcctca caccattgaa accactagtt ctgtcccccc     2820

aggagacctg gttgtgtgtg tgtgagtggt tgaccttcct ccatcccctg gtccttccct     2880

tcccttcccg aggcacagag agacagggca ggatccacgt gcccattgtg gaggcagaga     2940

aaagagaaag tgttttatat acggtactta tttaatatcc ctttttaatt agaaattaaa     3000

acagttaatt taattaaaga gtagggtttt ttttcagtat tcttggttaa tatttaattt     3060

caactattta tgagatgtat cttttgctct ctcttgctct cttatttgta ccggtttttg     3120

tatataaaat tcatgtttcc aatctctctc tccctgatcg gtgacagtca ctagcttatc     3180

ttgaacagat atttaatttt gctaacactc agctctgccc tccccgatcc cctggctccc     3240

cagcacacat tcctttgaaa taaggtttca atatacatct acatactata tatatatttg     3300

gcaacttgta tttgtgtgta tatatatata tatatgttta tgtatatatg tgattctgat     3360

aaaatagaca ttgctattct gttttttata tgtaaaaaca aaacaagaaa aaatagagaa     3420

ttctacatac taaatctctc tcctttttta attttaatat ttgttatcat ttatttattg     3480

gtgctactgt ttatccgtaa taattgtggg gaaaagatat taacatcacg tctttgtctc     3540

tagtgcagtt tttcgagata ttccgtagta catatttatt tttaaacaac gacaaagaaa     3600

tacagatata tcttaaaaaa aaaaaagcat tttgtattaa agaatttaat tctgatctca     3660

aaaaaaaaaa aaaaaaa                                                    3677


<210>  32
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


