                         SEQUENCE LISTING

<110>  Biostrategies LC
       Radin, David
 
<120>  Plant Lectins as Carriers of Associated Drug Substances into 
       Animal and Human Cells

<130>  BSL.100CXC1PCT

<150>  61/653,062
<151>  2012-05-30

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  919
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  1

Met Ala Ser Ser Ala Thr Thr Lys Ser Phe Leu Ile Leu Phe Phe Met 
1               5                   10                  15      


Ile Leu Ala Thr Thr Ser Ser Thr Cys Ala Val Asp Glu Ala Pro His 
            20                  25                  30          


Leu Val Gln Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe 
        35                  40                  45              


Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp 
    50                  55                  60                  


Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly 
65                  70                  75                  80  


Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu 
                85                  90                  95      


Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn 
            100                 105                 110         


Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu 
        115                 120                 125             


Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp 
    130                 135                 140                 


Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser 
145                 150                 155                 160 


Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys 
                165                 170                 175     


Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn 
            180                 185                 190         


Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser 
        195                 200                 205             


Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly 
    210                 215                 220                 


Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu 
225                 230                 235                 240 


Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val 
                245                 250                 255     


Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile 
            260                 265                 270         


Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu 
        275                 280                 285             


Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro 
    290                 295                 300                 


Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr 
305                 310                 315                 320 


Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu 
                325                 330                 335     


Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn 
            340                 345                 350         


Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr 
        355                 360                 365             


Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu 
    370                 375                 380                 


Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu 
385                 390                 395                 400 


Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser 
                405                 410                 415     


Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro 
            420                 425                 430         


Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr 
        435                 440                 445             


Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly 
    450                 455                 460                 


Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn 
465                 470                 475                 480 


Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val 
                485                 490                 495     


Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro 
            500                 505                 510         


Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu 
        515                 520                 525             


Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala 
    530                 535                 540                 


Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro 
545                 550                 555                 560 


Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly 
                565                 570                 575     


Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys 
            580                 585                 590         


Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val 
        595                 600                 605             


Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala 
    610                 615                 620                 


Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr 
625                 630                 635                 640 


Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro Leu 
                645                 650                 655     


Glu Pro Glu Pro Ile Val Arg Ile Val Gly Arg Asn Gly Leu Cys Val 
            660                 665                 670         


Asp Val Arg Asp Gly Arg Phe His Asn Gly Asn Ala Ile Gln Leu Trp 
        675                 680                 685             


Pro Cys Lys Ser Asn Thr Asp Ala Asn Gln Leu Trp Thr Leu Lys Arg 
    690                 695                 700                 


Asp Asn Thr Ile Arg Ser Asn Gly Lys Cys Leu Thr Thr Tyr Gly Tyr 
705                 710                 715                 720 


Ser Pro Gly Val Tyr Val Met Ile Tyr Asp Cys Asn Thr Ala Ala Thr 
                725                 730                 735     


Asp Ala Thr Arg Trp Gln Ile Trp Asp Asn Gly Thr Ile Ile Asn Pro 
            740                 745                 750         


Arg Ser Ser Leu Val Leu Ala Ala Thr Ser Gly Asn Ser Gly Thr Thr 
        755                 760                 765             


Leu Thr Val Gln Thr Asn Ile Tyr Ala Val Ser Gln Gly Trp Leu Pro 
    770                 775                 780                 


Thr Asn Asn Thr Gln Pro Phe Val Thr Thr Ile Val Gly Leu Tyr Gly 
785                 790                 795                 800 


Leu Cys Leu Gln Ala Asn Ser Gly Gln Val Trp Ile Glu Asp Cys Ser 
                805                 810                 815     


Ser Glu Lys Ala Glu Gln Gln Trp Ala Leu Tyr Ala Asp Gly Ser Ile 
            820                 825                 830         


Arg Pro Gln Gln Asn Arg Asp Asn Cys Leu Thr Ser Asp Ser Asn Ile 
        835                 840                 845             


Arg Glu Thr Val Val Lys Ile Leu Ser Cys Gly Pro Ala Ser Ser Gly 
    850                 855                 860                 


Gln Arg Trp Met Phe Lys Asn Asp Gly Thr Ile Leu Asn Leu Tyr Ser 
865                 870                 875                 880 


Gly Leu Val Leu Asp Val Arg Ala Ser Asp Pro Ser Leu Lys Gln Ile 
                885                 890                 895     


Ile Leu Tyr Pro Leu His Gly Asp Pro Asn Gln Ile Trp Leu Pro Leu 
            900                 905                 910         


Phe His His His His His His 
        915                 


<210>  2
<211>  930
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  2

Met Ala Ser Ser Ala Thr Thr Lys Ser Phe Leu Ile Leu Phe Phe Met 
1               5                   10                  15      


Ile Leu Ala Thr Thr Ser Ser Thr Cys Ala Val Asp Glu Ala Pro His 
            20                  25                  30          


Leu Val Gln Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe 
        35                  40                  45              


Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp 
    50                  55                  60                  


Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly 
65                  70                  75                  80  


Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu 
                85                  90                  95      


Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn 
            100                 105                 110         


Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu 
        115                 120                 125             


Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp 
    130                 135                 140                 


Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser 
145                 150                 155                 160 


Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys 
                165                 170                 175     


Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn 
            180                 185                 190         


Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser 
        195                 200                 205             


Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly 
    210                 215                 220                 


Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu 
225                 230                 235                 240 


Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val 
                245                 250                 255     


Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile 
            260                 265                 270         


Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu 
        275                 280                 285             


Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro 
    290                 295                 300                 


Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr 
305                 310                 315                 320 


Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu 
                325                 330                 335     


Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn 
            340                 345                 350         


Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr 
        355                 360                 365             


Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu 
    370                 375                 380                 


Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu 
385                 390                 395                 400 


Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser 
                405                 410                 415     


Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro 
            420                 425                 430         


Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr 
        435                 440                 445             


Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly 
    450                 455                 460                 


Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn 
465                 470                 475                 480 


Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val 
                485                 490                 495     


Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro 
            500                 505                 510         


Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu 
        515                 520                 525             


Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala 
    530                 535                 540                 


Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro 
545                 550                 555                 560 


Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly 
                565                 570                 575     


Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys 
            580                 585                 590         


Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val 
        595                 600                 605             


Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala 
    610                 615                 620                 


Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr 
625                 630                 635                 640 


Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro Leu 
                645                 650                 655     


Glu Gly Glu Thr Ser Thr Leu Arg Thr Ser Phe Thr Arg Asn Ile Val 
            660                 665                 670         


Gly Arg Asp Gly Leu Cys Val Asp Val Arg Asn Gly Tyr Asp Thr Asp 
        675                 680                 685             


Gly Thr Pro Leu Gln Leu Trp Pro Cys Gly Thr Gln Arg Asn Gln Arg 
    690                 695                 700                 


Trp Thr Phe Asp Ser Asp Asp Thr Ile Arg Ser Met Gly Lys Cys Met 
705                 710                 715                 720 


Thr Ala Asn Gly Leu Asn Asn Gly Ser Asn Ile Val Ile Phe Asn Cys 
                725                 730                 735     


Ser Thr Ala Ala Glu Asn Ala Ile Lys Trp Glu Val Pro Ile Asp Gly 
            740                 745                 750         


Ser Ile Ile Asn Pro Ser Ser Gly Leu Val Met Thr Ala Pro Arg Ala 
        755                 760                 765             


Ala Ser Arg Thr Ile Leu Leu Leu Glu Asp Asn Ile Tyr Ala Ala Ser 
    770                 775                 780                 


Gln Gly Trp Thr Val Thr Asn Asn Val Lys Pro Ile Val Ala Ser Ile 
785                 790                 795                 800 


Val Gly Tyr Lys Glu Met Cys Leu Gln Ser Asn Gly Glu Asn Asn Gly 
                805                 810                 815     


Val Trp Met Glu Asp Cys Glu Ala Thr Ser Leu Gln Gln Gln Trp Ala 
            820                 825                 830         


Leu Tyr Gly Asp Arg Thr Ile Arg Val Asn Ser Thr Arg Gly Leu Cys 
        835                 840                 845             


Val Thr Thr Asn Gly Tyr Asn Ser Lys Asp Leu Ile Ile Ile Leu Lys 
    850                 855                 860                 


Cys Gln Gly Leu Pro Ser Gln Arg Trp Phe Phe Asn Ser Asp Gly Ala 
865                 870                 875                 880 


Ile Val Asn Pro Lys Ser Arg His Val Met Asp Val Arg Ala Ser Asn 
                885                 890                 895     


Val Ser Leu Arg Glu Ile Ile Ile Phe Pro Ala Thr Gly Asn Pro Asn 
            900                 905                 910         


Gln Gln Trp Val Thr Gln Val Leu Pro Ser Pro Gly His His His His 
        915                 920                 925             


His His 
    930 


<210>  3
<211>  527
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  3

Met Ala Ser Ser Ala Thr Thr Lys Ser Phe Leu Ile Leu Phe Phe Met 
1               5                   10                  15      


Ile Leu Ala Thr Thr Ser Ser Thr Cys Ala Val Val Arg Ser Ser Lys 
            20                  25                  30          


Asn Val Ile Lys Glu Phe Met Arg Phe Lys Val Arg Met Glu Gly Thr 
        35                  40                  45              


Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro 
    50                  55                  60                  


Tyr Glu Gly His Asn Thr Val Lys Leu Lys Val Thr Lys Gly Gly Pro 
65                  70                  75                  80  


Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Gln Tyr Gly Ser 
                85                  90                  95      


Lys Val Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Lys Lys Leu 
            100                 105                 110         


Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp 
        115                 120                 125             


Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Cys 
    130                 135                 140                 


Phe Ile Tyr Lys Val Lys Phe Ile Gly Val Asn Phe Pro Ser Asp Gly 
145                 150                 155                 160 


Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu Arg 
                165                 170                 175     


Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu Ile His Lys Ala Leu 
            180                 185                 190         


Lys Leu Lys Asp Gly Gly His Tyr Leu Val Glu Phe Lys Ser Ile Tyr 
        195                 200                 205             


Met Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln 
225                 230                 235                 240 


Tyr Glu Arg Thr Glu Gly Arg His His Leu Phe Leu Leu Glu Gly Glu 
                245                 250                 255     


Thr Ser Thr Leu Arg Thr Ser Phe Thr Arg Asn Ile Val Gly Arg Asp 
            260                 265                 270         


Gly Leu Cys Val Asp Val Arg Asn Gly Tyr Asp Thr Asp Gly Thr Pro 
        275                 280                 285             


Leu Gln Leu Trp Pro Cys Gly Thr Gln Arg Asn Gln Arg Trp Thr Phe 
    290                 295                 300                 


Asp Ser Asp Asp Thr Ile Arg Ser Met Gly Lys Cys Met Thr Ala Asn 
305                 310                 315                 320 


Gly Leu Asn Asn Gly Ser Asn Ile Val Ile Phe Asn Cys Ser Thr Ala 
                325                 330                 335     


Ala Glu Asn Ala Ile Lys Trp Glu Val Pro Ile Asp Gly Ser Ile Ile 
            340                 345                 350         


Asn Pro Ser Ser Gly Leu Val Met Thr Ala Pro Arg Ala Ala Ser Arg 
        355                 360                 365             


Thr Ile Leu Leu Leu Glu Asp Asn Ile Tyr Ala Ala Ser Gln Gly Trp 
    370                 375                 380                 


Thr Val Thr Asn Asn Val Lys Pro Ile Val Ala Ser Ile Val Gly Tyr 
385                 390                 395                 400 


Lys Glu Met Cys Leu Gln Ser Asn Gly Glu Asn Asn Gly Val Trp Met 
                405                 410                 415     


Glu Asp Cys Glu Ala Thr Ser Leu Gln Gln Gln Trp Ala Leu Tyr Gly 
            420                 425                 430         


Asp Arg Thr Ile Arg Val Asn Ser Thr Arg Gly Leu Cys Val Thr Thr 
        435                 440                 445             


Asn Gly Tyr Asn Ser Lys Asp Leu Ile Ile Ile Leu Lys Cys Gln Gly 
    450                 455                 460                 


Leu Pro Ser Gln Arg Trp Phe Phe Asn Ser Asp Gly Ala Ile Val Asn 
465                 470                 475                 480 


Pro Lys Ser Arg His Val Met Asp Val Arg Ala Ser Asn Val Ser Leu 
                485                 490                 495     


Arg Glu Ile Ile Ile Phe Pro Ala Thr Gly Asn Pro Asn Gln Gln Trp 
            500                 505                 510         


Val Thr Gln Val Leu Pro Ser Pro Gly His His His His His His 
        515                 520                 525         


<210>  4
<211>  783
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  4

Met Ala Ser Ser Ala Thr Thr Lys Ser Phe Leu Ile Leu Phe Phe Met 
1               5                   10                  15      


Ile Leu Ala Thr Thr Ser Ser Thr Cys Ala Val Asp Gly Glu Thr Ser 
            20                  25                  30          


Thr Leu Arg Thr Ser Phe Thr Arg Asn Ile Val Gly Arg Asp Gly Leu 
        35                  40                  45              


Cys Val Asp Val Arg Asn Gly Tyr Asp Thr Asp Gly Thr Pro Leu Gln 
    50                  55                  60                  


Leu Trp Pro Cys Gly Thr Gln Arg Asn Gln Arg Trp Thr Phe Asp Ser 
65                  70                  75                  80  


Asp Asp Thr Ile Arg Ser Met Gly Lys Cys Met Thr Ala Asn Gly Leu 
                85                  90                  95      


Asn Asn Gly Ser Asn Ile Val Ile Phe Asn Cys Ser Thr Ala Ala Glu 
            100                 105                 110         


Asn Ala Ile Lys Trp Glu Val Pro Ile Asp Gly Ser Ile Ile Asn Pro 
        115                 120                 125             


Ser Ser Gly Leu Val Met Thr Ala Pro Arg Ala Ala Ser Arg Thr Ile 
    130                 135                 140                 


Leu Leu Leu Glu Asp Asn Ile Tyr Ala Ala Ser Gln Gly Trp Thr Val 
145                 150                 155                 160 


Thr Asn Asn Val Lys Pro Ile Val Ala Ser Ile Val Gly Tyr Lys Glu 
                165                 170                 175     


Met Cys Leu Gln Ser Asn Gly Glu Asn Asn Gly Val Trp Met Glu Asp 
            180                 185                 190         


Cys Glu Ala Thr Ser Leu Gln Gln Gln Trp Ala Leu Tyr Gly Asp Arg 
        195                 200                 205             


Thr Ile Arg Val Asn Ser Thr Arg Gly Leu Cys Val Thr Thr Asn Gly 
    210                 215                 220                 


Tyr Asn Ser Lys Asp Leu Ile Ile Ile Leu Lys Cys Gln Gly Leu Pro 
225                 230                 235                 240 


Ser Gln Arg Trp Phe Phe Asn Ser Asp Gly Ala Ile Val Asn Pro Lys 
                245                 250                 255     


Ser Arg His Val Met Asp Val Arg Ala Ser Asn Val Ser Leu Arg Glu 
            260                 265                 270         


Ile Ile Ile Phe Pro Ala Thr Gly Asn Pro Asn Gln Gln Trp Val Thr 
        275                 280                 285             


Gln Val Leu Pro Ser Leu Glu Arg Pro Arg Asn Ala Leu Leu Leu Leu 
    290                 295                 300                 


Ala Asp Asp Gly Gly Phe Glu Ser Gly Ala Tyr Asn Asn Ser Ala Ile 
305                 310                 315                 320 


Ala Thr Pro His Leu Asp Ala Leu Ala Arg Arg Ser Leu Leu Phe Arg 
                325                 330                 335     


Asn Ala Phe Thr Ser Val Ser Ser Cys Ser Pro Ser Arg Ala Ser Leu 
            340                 345                 350         


Leu Thr Gly Leu Pro Gln His Gln Asn Gly Met Tyr Gly Leu His Gln 
        355                 360                 365             


Asp Val His His Phe Asn Ser Phe Asp Lys Val Arg Ser Leu Pro Leu 
    370                 375                 380                 


Leu Leu Ser Gln Ala Gly Val Arg Thr Gly Ile Ile Gly Lys Lys His 
385                 390                 395                 400 


Val Gly Pro Glu Thr Val Tyr Pro Phe Asp Phe Ala Tyr Thr Glu Glu 
                405                 410                 415     


Asn Gly Ser Val Leu Gln Val Gly Arg Asn Ile Thr Arg Ile Lys Leu 
            420                 425                 430         


Leu Val Arg Lys Phe Leu Gln Thr Gln Asp Asp Arg Pro Phe Phe Leu 
        435                 440                 445             


Tyr Val Ala Phe His Asp Pro His Arg Cys Gly His Ser Gln Pro Gln 
    450                 455                 460                 


Tyr Gly Thr Phe Cys Glu Lys Phe Gly Asn Gly Glu Ser Gly Met Gly 
465                 470                 475                 480 


Arg Ile Pro Asp Trp Thr Pro Gln Ala Tyr Asp Pro Leu Asp Val Leu 
                485                 490                 495     


Val Pro Tyr Phe Val Pro Asn Thr Pro Ala Ala Arg Ala Asp Leu Ala 
            500                 505                 510         


Ala Gln Tyr Thr Thr Val Gly Arg Met Asp Gln Gly Val Gly Leu Val 
        515                 520                 525             


Leu Gln Glu Leu Arg Asp Ala Gly Val Leu Asn Asp Thr Leu Val Ile 
    530                 535                 540                 


Phe Thr Ser Asp Asn Gly Ile Pro Phe Pro Ser Gly Arg Thr Asn Leu 
545                 550                 555                 560 


Tyr Trp Pro Gly Thr Ala Glu Pro Leu Leu Val Ser Ser Pro Glu His 
                565                 570                 575     


Pro Lys Arg Trp Gly Gln Val Ser Glu Ala Tyr Val Ser Leu Leu Asp 
            580                 585                 590         


Leu Thr Pro Thr Ile Leu Asp Trp Phe Ser Ile Pro Tyr Pro Ser Tyr 
        595                 600                 605             


Ala Ile Phe Gly Ser Lys Thr Ile His Leu Thr Gly Arg Ser Leu Leu 
    610                 615                 620                 


Pro Ala Leu Glu Ala Glu Pro Leu Trp Ala Thr Val Phe Gly Ser Gln 
625                 630                 635                 640 


Ser His His Glu Val Thr Met Ser Tyr Pro Met Arg Ser Val Gln His 
                645                 650                 655     


Arg His Phe Arg Leu Val His Asn Leu Asn Phe Lys Met Pro Phe Pro 
            660                 665                 670         


Ile Asp Gln Asp Phe Tyr Val Ser Pro Thr Phe Gln Asp Leu Leu Asn 
        675                 680                 685             


Arg Thr Thr Ala Gly Gln Pro Thr Gly Trp Tyr Lys Asp Leu Arg His 
    690                 695                 700                 


Tyr Tyr Tyr Arg Ala Arg Trp Glu Leu Tyr Asp Arg Ser Arg Asp Pro 
705                 710                 715                 720 


His Glu Thr Gln Asn Leu Ala Thr Asp Pro Arg Phe Ala Gln Leu Leu 
                725                 730                 735     


Glu Met Leu Arg Asp Gln Leu Ala Lys Trp Gln Trp Glu Thr His Asp 
            740                 745                 750         


Pro Trp Val Cys Ala Pro Asp Gly Val Leu Glu Glu Lys Leu Ser Pro 
        755                 760                 765             


Gln Cys Gln Pro Leu His Asn Glu Leu His His His His His His 
    770                 775                 780             


<210>  5
<211>  766
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  5

Met Ser Cys Pro Val Pro Ala Cys Cys Ala Leu Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Cys Arg Ala Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp 
            20                  25                  30          


Gly Gly Phe Glu Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro 
        35                  40                  45              


His Leu Asp Ala Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe 
    50                  55                  60                  


Thr Ser Val Ser Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly 
65                  70                  75                  80  


Leu Pro Gln His Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His 
                85                  90                  95      


His Phe Asn Ser Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser 
            100                 105                 110         


Gln Ala Gly Val Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro 
        115                 120                 125             


Glu Thr Val Tyr Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser 
    130                 135                 140                 


Val Leu Gln Val Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg 
145                 150                 155                 160 


Lys Phe Leu Gln Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala 
                165                 170                 175     


Phe His Asp Pro His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr 
            180                 185                 190         


Phe Cys Glu Lys Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro 
        195                 200                 205             


Asp Trp Thr Pro Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr 
    210                 215                 220                 


Phe Val Pro Asn Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Thr Thr Val Gly Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu 
                245                 250                 255     


Leu Arg Asp Ala Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser 
            260                 265                 270         


Asp Asn Gly Ile Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro 
        275                 280                 285             


Gly Thr Ala Glu Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg 
    290                 295                 300                 


Trp Gly Gln Val Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro 
305                 310                 315                 320 


Thr Ile Leu Asp Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe 
                325                 330                 335     


Gly Ser Lys Thr Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu 
            340                 345                 350         


Glu Ala Glu Pro Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His 
        355                 360                 365             


Glu Val Thr Met Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe 
    370                 375                 380                 


Arg Leu Val His Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln 
385                 390                 395                 400 


Asp Phe Tyr Val Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr 
                405                 410                 415     


Ala Gly Gln Pro Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr 
            420                 425                 430         


Arg Ala Arg Trp Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr 
        435                 440                 445             


Gln Asn Leu Ala Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu 
    450                 455                 460                 


Arg Asp Gln Leu Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val 
465                 470                 475                 480 


Cys Ala Pro Asp Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln 
                485                 490                 495     


Pro Leu His Asn Glu Leu Leu Glu Pro Glu Pro Ile Val Arg Ile Val 
            500                 505                 510         


Gly Arg Asn Gly Leu Cys Val Asp Val Arg Asp Gly Arg Phe His Asn 
        515                 520                 525             


Gly Asn Ala Ile Gln Leu Trp Pro Cys Lys Ser Asn Thr Asp Ala Asn 
    530                 535                 540                 


Gln Leu Trp Thr Leu Lys Arg Asp Asn Thr Ile Arg Ser Asn Gly Lys 
545                 550                 555                 560 


Cys Leu Thr Thr Tyr Gly Tyr Ser Pro Gly Val Tyr Val Met Ile Tyr 
                565                 570                 575     


Asp Cys Asn Thr Ala Ala Thr Asp Ala Thr Arg Trp Gln Ile Trp Asp 
            580                 585                 590         


Asn Gly Thr Ile Ile Asn Pro Arg Ser Ser Leu Val Leu Ala Ala Thr 
        595                 600                 605             


Ser Gly Asn Ser Gly Thr Thr Leu Thr Val Gln Thr Asn Ile Tyr Ala 
    610                 615                 620                 


Val Ser Gln Gly Trp Leu Pro Thr Asn Asn Thr Gln Pro Phe Val Thr 
625                 630                 635                 640 


Thr Ile Val Gly Leu Tyr Gly Leu Cys Leu Gln Ala Asn Ser Gly Gln 
                645                 650                 655     


Val Trp Ile Glu Asp Cys Ser Ser Glu Lys Ala Glu Gln Gln Trp Ala 
            660                 665                 670         


Leu Tyr Ala Asp Gly Ser Ile Arg Pro Gln Gln Asn Arg Asp Asn Cys 
        675                 680                 685             


Leu Thr Ser Asp Ser Asn Ile Arg Glu Thr Val Val Lys Ile Leu Ser 
    690                 695                 700                 


Cys Gly Pro Ala Ser Ser Gly Gln Arg Trp Met Phe Lys Asn Asp Gly 
705                 710                 715                 720 


Thr Ile Leu Asn Leu Tyr Ser Gly Leu Val Leu Asp Val Arg Ala Ser 
                725                 730                 735     


Asp Pro Ser Leu Lys Gln Ile Ile Leu Tyr Pro Leu His Gly Asp Pro 
            740                 745                 750         


Asn Gln Ile Trp Leu Pro Leu Phe His His His His His His 
        755                 760                 765     


<210>  6
<211>  883
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  6

Glu Ala Pro His Leu Val Gln Val Asp Ala Ala Arg Ala Leu Trp Pro 
1               5                   10                  15      


Leu Arg Arg Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His 
            20                  25                  30          


Ser Gln Ala Asp Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu 
        35                  40                  45              


Ala Tyr Val Gly Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr 
    50                  55                  60                  


His Trp Leu Leu Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly 
65                  70                  75                  80  


Leu Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg 
                85                  90                  95      


Glu Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly 
            100                 105                 110         


His Phe Thr Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp 
        115                 120                 125             


Leu Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala 
    130                 135                 140                 


His Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His 
145                 150                 155                 160 


Asp Phe Asp Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr 
                165                 170                 175     


Asp Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu 
            180                 185                 190         


Gly Gly Pro Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser 
        195                 200                 205             


Trp Gly Leu Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly 
    210                 215                 220                 


Glu Ala Gly Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala 
225                 230                 235                 240 


Arg Ser Ser Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln 
                245                 250                 255     


Ile Arg Gln Leu Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp 
            260                 265                 270         


Glu Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala 
        275                 280                 285             


Asp Val Thr Tyr Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln 
    290                 295                 300                 


Asn Leu Leu Leu Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu 
305                 310                 315                 320 


Ser Asn Asp Asn Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln 
                325                 330                 335     


Arg Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His 
            340                 345                 350         


Val Gln Leu Leu Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala 
        355                 360                 365             


Leu Leu Asp Glu Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr 
    370                 375                 380                 


Val Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg 
385                 390                 395                 400 


Pro Gln Gly Pro Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala 
                405                 410                 415     


Ser Asp Asp Thr Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu 
            420                 425                 430         


Arg Leu Arg Gly Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg 
        435                 440                 445             


Tyr Leu Asp Asn Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu 
    450                 455                 460                 


Gly Arg Pro Val Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala 
465                 470                 475                 480 


Ala Glu Asp Pro Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly 
                485                 490                 495     


Arg Leu Thr Leu Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val 
            500                 505                 510         


His Val Cys Ala Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu 
        515                 520                 525             


Arg Ala Leu Pro Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp 
    530                 535                 540                 


Glu His Val Gly Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser 
545                 550                 555                 560 


Gln Asp Gly Lys Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe 
                565                 570                 575     


Asn Leu Phe Val Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr 
            580                 585                 590         


Arg Val Arg Ala Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp 
        595                 600                 605             


Pro Val Pro Tyr Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro 
    610                 615                 620                 


Gly Asn Pro Pro Glu Pro Ile Val Arg Ile Val Gly Arg Asn Gly Leu 
625                 630                 635                 640 


Cys Val Asp Val Arg Asp Gly Arg Phe His Asn Gly Asn Ala Ile Gln 
                645                 650                 655     


Leu Trp Pro Cys Lys Ser Asn Thr Asp Ala Asn Gln Leu Trp Thr Leu 
            660                 665                 670         


Lys Arg Asp Asn Thr Ile Arg Ser Asn Gly Lys Cys Leu Thr Thr Tyr 
        675                 680                 685             


Gly Tyr Ser Pro Gly Val Tyr Val Met Ile Tyr Asp Cys Asn Thr Ala 
    690                 695                 700                 


Ala Thr Asp Ala Thr Arg Trp Gln Ile Trp Asp Asn Gly Thr Ile Ile 
705                 710                 715                 720 


Asn Pro Arg Ser Ser Leu Val Leu Ala Ala Thr Ser Gly Asn Ser Gly 
                725                 730                 735     


Thr Thr Leu Thr Val Gln Thr Asn Ile Tyr Ala Val Ser Gln Gly Trp 
            740                 745                 750         


Leu Pro Thr Asn Asn Thr Gln Pro Phe Val Thr Thr Ile Val Gly Leu 
        755                 760                 765             


Tyr Gly Leu Cys Leu Gln Ala Asn Ser Gly Gln Val Trp Ile Glu Asp 
    770                 775                 780                 


Cys Ser Ser Glu Lys Ala Glu Gln Gln Trp Ala Leu Tyr Ala Asp Gly 
785                 790                 795                 800 


Ser Ile Arg Pro Gln Gln Asn Arg Asp Asn Cys Leu Thr Ser Asp Ser 
                805                 810                 815     


Asn Ile Arg Glu Thr Val Val Lys Ile Leu Ser Cys Gly Pro Ala Ser 
            820                 825                 830         


Ser Gly Gln Arg Trp Met Phe Lys Asn Asp Gly Thr Ile Leu Asn Leu 
        835                 840                 845             


Tyr Ser Gly Leu Val Leu Asp Val Arg Ala Ser Asp Pro Ser Leu Lys 
    850                 855                 860                 


Gln Ile Ile Leu Tyr Pro Leu His Gly Asp Pro Asn Gln Ile Trp Leu 
865                 870                 875                 880 


Pro Leu Phe 
            


<210>  7
<211>  892
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  7

Glu Ala Pro His Leu Val Gln Val Asp Ala Ala Arg Ala Leu Trp Pro 
1               5                   10                  15      


Leu Arg Arg Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His 
            20                  25                  30          


Ser Gln Ala Asp Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu 
        35                  40                  45              


Ala Tyr Val Gly Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr 
    50                  55                  60                  


His Trp Leu Leu Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly 
65                  70                  75                  80  


Leu Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg 
                85                  90                  95      


Glu Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly 
            100                 105                 110         


His Phe Thr Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp 
        115                 120                 125             


Leu Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala 
    130                 135                 140                 


His Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His 
145                 150                 155                 160 


Asp Phe Asp Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr 
                165                 170                 175     


Asp Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu 
            180                 185                 190         


Gly Gly Pro Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser 
        195                 200                 205             


Trp Gly Leu Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly 
    210                 215                 220                 


Glu Ala Gly Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala 
225                 230                 235                 240 


Arg Ser Ser Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln 
                245                 250                 255     


Ile Arg Gln Leu Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp 
            260                 265                 270         


Glu Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala 
        275                 280                 285             


Asp Val Thr Tyr Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln 
    290                 295                 300                 


Asn Leu Leu Leu Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu 
305                 310                 315                 320 


Ser Asn Asp Asn Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln 
                325                 330                 335     


Arg Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His 
            340                 345                 350         


Val Gln Leu Leu Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala 
        355                 360                 365             


Leu Leu Asp Glu Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr 
    370                 375                 380                 


Val Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg 
385                 390                 395                 400 


Pro Gln Gly Pro Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala 
                405                 410                 415     


Ser Asp Asp Thr Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu 
            420                 425                 430         


Arg Leu Arg Gly Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg 
        435                 440                 445             


Tyr Leu Asp Asn Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu 
    450                 455                 460                 


Gly Arg Pro Val Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala 
465                 470                 475                 480 


Ala Glu Asp Pro Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly 
                485                 490                 495     


Arg Leu Thr Leu Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val 
            500                 505                 510         


His Val Cys Ala Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu 
        515                 520                 525             


Arg Ala Leu Pro Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp 
    530                 535                 540                 


Glu His Val Gly Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser 
545                 550                 555                 560 


Gln Asp Gly Lys Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe 
                565                 570                 575     


Asn Leu Phe Val Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr 
            580                 585                 590         


Arg Val Arg Ala Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp 
        595                 600                 605             


Pro Val Pro Tyr Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro 
    610                 615                 620                 


Gly Asn Pro Gly Glu Thr Ser Thr Leu Arg Thr Ser Phe Thr Arg Asn 
625                 630                 635                 640 


Ile Val Gly Arg Asp Gly Leu Cys Val Asp Val Arg Asn Gly Tyr Asp 
                645                 650                 655     


Thr Asp Gly Thr Pro Leu Gln Leu Trp Pro Cys Gly Thr Gln Arg Asn 
            660                 665                 670         


Gln Arg Trp Thr Phe Asp Ser Asp Asp Thr Ile Arg Ser Met Gly Lys 
        675                 680                 685             


Cys Met Thr Ala Asn Gly Leu Asn Asn Gly Ser Asn Ile Val Ile Phe 
    690                 695                 700                 


Asn Cys Ser Thr Ala Ala Glu Asn Ala Ile Lys Trp Glu Val Pro Ile 
705                 710                 715                 720 


Asp Gly Ser Ile Ile Asn Pro Ser Ser Gly Leu Val Met Thr Ala Pro 
                725                 730                 735     


Arg Ala Ala Ser Arg Thr Ile Leu Leu Leu Glu Asp Asn Ile Tyr Ala 
            740                 745                 750         


Ala Ser Gln Gly Trp Thr Val Thr Asn Asn Val Lys Pro Ile Val Ala 
        755                 760                 765             


Ser Ile Val Gly Tyr Lys Glu Met Cys Leu Gln Ser Asn Gly Glu Asn 
    770                 775                 780                 


Asn Gly Val Trp Met Glu Asp Cys Glu Ala Thr Ser Leu Gln Gln Gln 
785                 790                 795                 800 


Trp Ala Leu Tyr Gly Asp Arg Thr Ile Arg Val Asn Ser Thr Arg Gly 
                805                 810                 815     


Leu Cys Val Thr Thr Asn Gly Tyr Asn Ser Lys Asp Leu Ile Ile Ile 
            820                 825                 830         


Leu Lys Cys Gln Gly Leu Pro Ser Gln Arg Trp Phe Phe Asn Ser Asp 
        835                 840                 845             


Gly Ala Ile Val Asn Pro Lys Ser Arg His Val Met Asp Val Arg Ala 
    850                 855                 860                 


Ser Asn Val Ser Leu Arg Glu Ile Ile Ile Phe Pro Ala Thr Gly Asn 
865                 870                 875                 880 


Pro Asn Gln Gln Trp Val Thr Gln Val Leu Pro Ser 
                885                 890         


<210>  8
<211>  490
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  8

Val Arg Ser Ser Lys Asn Val Ile Lys Glu Phe Met Arg Phe Lys Val 
1               5                   10                  15      


Arg Met Glu Gly Thr Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
            20                  25                  30          


Gly Glu Gly Arg Pro Tyr Glu Gly His Asn Thr Val Lys Leu Lys Val 
        35                  40                  45              


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
    50                  55                  60                  


Phe Gln Tyr Gly Ser Lys Val Tyr Val Lys His Pro Ala Asp Ile Pro 
65                  70                  75                  80  


Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val 
                85                  90                  95      


Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser 
            100                 105                 110         


Leu Gln Asp Gly Cys Phe Ile Tyr Lys Val Lys Phe Ile Gly Val Asn 
        115                 120                 125             


Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu 
    130                 135                 140                 


Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu 
145                 150                 155                 160 


Ile His Lys Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val Glu 
                165                 170                 175     


Phe Lys Ser Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr 
            180                 185                 190         


Tyr Tyr Val Asp Ser Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr 
        195                 200                 205             


Thr Ile Val Glu Gln Tyr Glu Arg Thr Glu Gly Arg His His Leu Phe 
    210                 215                 220                 


Leu Gly Glu Thr Ser Thr Leu Arg Thr Ser Phe Thr Arg Asn Ile Val 
225                 230                 235                 240 


Gly Arg Asp Gly Leu Cys Val Asp Val Arg Asn Gly Tyr Asp Thr Asp 
                245                 250                 255     


Gly Thr Pro Leu Gln Leu Trp Pro Cys Gly Thr Gln Arg Asn Gln Arg 
            260                 265                 270         


Trp Thr Phe Asp Ser Asp Asp Thr Ile Arg Ser Met Gly Lys Cys Met 
        275                 280                 285             


Thr Ala Asn Gly Leu Asn Asn Gly Ser Asn Ile Val Ile Phe Asn Cys 
    290                 295                 300                 


Ser Thr Ala Ala Glu Asn Ala Ile Lys Trp Glu Val Pro Ile Asp Gly 
305                 310                 315                 320 


Ser Ile Ile Asn Pro Ser Ser Gly Leu Val Met Thr Ala Pro Arg Ala 
                325                 330                 335     


Ala Ser Arg Thr Ile Leu Leu Leu Glu Asp Asn Ile Tyr Ala Ala Ser 
            340                 345                 350         


Gln Gly Trp Thr Val Thr Asn Asn Val Lys Pro Ile Val Ala Ser Ile 
        355                 360                 365             


Val Gly Tyr Lys Glu Met Cys Leu Gln Ser Asn Gly Glu Asn Asn Gly 
    370                 375                 380                 


Val Trp Met Glu Asp Cys Glu Ala Thr Ser Leu Gln Gln Gln Trp Ala 
385                 390                 395                 400 


Leu Tyr Gly Asp Arg Thr Ile Arg Val Asn Ser Thr Arg Gly Leu Cys 
                405                 410                 415     


Val Thr Thr Asn Gly Tyr Asn Ser Lys Asp Leu Ile Ile Ile Leu Lys 
            420                 425                 430         


Cys Gln Gly Leu Pro Ser Gln Arg Trp Phe Phe Asn Ser Asp Gly Ala 
        435                 440                 445             


Ile Val Asn Pro Lys Ser Arg His Val Met Asp Val Arg Ala Ser Asn 
    450                 455                 460                 


Val Ser Leu Arg Glu Ile Ile Ile Phe Pro Ala Thr Gly Asn Pro Asn 
465                 470                 475                 480 


Gln Gln Trp Val Thr Gln Val Leu Pro Ser 
                485                 490 


<210>  9
<211>  747
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  9

Gly Glu Thr Ser Thr Leu Arg Thr Ser Phe Thr Arg Asn Ile Val Gly 
1               5                   10                  15      


Arg Asp Gly Leu Cys Val Asp Val Arg Asn Gly Tyr Asp Thr Asp Gly 
            20                  25                  30          


Thr Pro Leu Gln Leu Trp Pro Cys Gly Thr Gln Arg Asn Gln Arg Trp 
        35                  40                  45              


Thr Phe Asp Ser Asp Asp Thr Ile Arg Ser Met Gly Lys Cys Met Thr 
    50                  55                  60                  


Ala Asn Gly Leu Asn Asn Gly Ser Asn Ile Val Ile Phe Asn Cys Ser 
65                  70                  75                  80  


Thr Ala Ala Glu Asn Ala Ile Lys Trp Glu Val Pro Ile Asp Gly Ser 
                85                  90                  95      


Ile Ile Asn Pro Ser Ser Gly Leu Val Met Thr Ala Pro Arg Ala Ala 
            100                 105                 110         


Ser Arg Thr Ile Leu Leu Leu Glu Asp Asn Ile Tyr Ala Ala Ser Gln 
        115                 120                 125             


Gly Trp Thr Val Thr Asn Asn Val Lys Pro Ile Val Ala Ser Ile Val 
    130                 135                 140                 


Gly Tyr Lys Glu Met Cys Leu Gln Ser Asn Gly Glu Asn Asn Gly Val 
145                 150                 155                 160 


Trp Met Glu Asp Cys Glu Ala Thr Ser Leu Gln Gln Gln Trp Ala Leu 
                165                 170                 175     


Tyr Gly Asp Arg Thr Ile Arg Val Asn Ser Thr Arg Gly Leu Cys Val 
            180                 185                 190         


Thr Thr Asn Gly Tyr Asn Ser Lys Asp Leu Ile Ile Ile Leu Lys Cys 
        195                 200                 205             


Gln Gly Leu Pro Ser Gln Arg Trp Phe Phe Asn Ser Asp Gly Ala Ile 
    210                 215                 220                 


Val Asn Pro Lys Ser Arg His Val Met Asp Val Arg Ala Ser Asn Val 
225                 230                 235                 240 


Ser Leu Arg Glu Ile Ile Ile Phe Pro Ala Thr Gly Asn Pro Asn Gln 
                245                 250                 255     


Gln Trp Val Thr Gln Val Leu Pro Ser Arg Pro Arg Asn Ala Leu Leu 
            260                 265                 270         


Leu Leu Ala Asp Asp Gly Gly Phe Glu Ser Gly Ala Tyr Asn Asn Ser 
        275                 280                 285             


Ala Ile Ala Thr Pro His Leu Asp Ala Leu Ala Arg Arg Ser Leu Leu 
    290                 295                 300                 


Phe Arg Asn Ala Phe Thr Ser Val Ser Ser Cys Ser Pro Ser Arg Ala 
305                 310                 315                 320 


Ser Leu Leu Thr Gly Leu Pro Gln His Gln Asn Gly Met Tyr Gly Leu 
                325                 330                 335     


His Gln Asp Val His His Phe Asn Ser Phe Asp Lys Val Arg Ser Leu 
            340                 345                 350         


Pro Leu Leu Leu Ser Gln Ala Gly Val Arg Thr Gly Ile Ile Gly Lys 
        355                 360                 365             


Lys His Val Gly Pro Glu Thr Val Tyr Pro Phe Asp Phe Ala Tyr Thr 
    370                 375                 380                 


Glu Glu Asn Gly Ser Val Leu Gln Val Gly Arg Asn Ile Thr Arg Ile 
385                 390                 395                 400 


Lys Leu Leu Val Arg Lys Phe Leu Gln Thr Gln Asp Asp Arg Pro Phe 
                405                 410                 415     


Phe Leu Tyr Val Ala Phe His Asp Pro His Arg Cys Gly His Ser Gln 
            420                 425                 430         


Pro Gln Tyr Gly Thr Phe Cys Glu Lys Phe Gly Asn Gly Glu Ser Gly 
        435                 440                 445             


Met Gly Arg Ile Pro Asp Trp Thr Pro Gln Ala Tyr Asp Pro Leu Asp 
    450                 455                 460                 


Val Leu Val Pro Tyr Phe Val Pro Asn Thr Pro Ala Ala Arg Ala Asp 
465                 470                 475                 480 


Leu Ala Ala Gln Tyr Thr Thr Val Gly Arg Met Asp Gln Gly Val Gly 
                485                 490                 495     


Leu Val Leu Gln Glu Leu Arg Asp Ala Gly Val Leu Asn Asp Thr Leu 
            500                 505                 510         


Val Ile Phe Thr Ser Asp Asn Gly Ile Pro Phe Pro Ser Gly Arg Thr 
        515                 520                 525             


Asn Leu Tyr Trp Pro Gly Thr Ala Glu Pro Leu Leu Val Ser Ser Pro 
    530                 535                 540                 


Glu His Pro Lys Arg Trp Gly Gln Val Ser Glu Ala Tyr Val Ser Leu 
545                 550                 555                 560 


Leu Asp Leu Thr Pro Thr Ile Leu Asp Trp Phe Ser Ile Pro Tyr Pro 
                565                 570                 575     


Ser Tyr Ala Ile Phe Gly Ser Lys Thr Ile His Leu Thr Gly Arg Ser 
            580                 585                 590         


Leu Leu Pro Ala Leu Glu Ala Glu Pro Leu Trp Ala Thr Val Phe Gly 
        595                 600                 605             


Ser Gln Ser His His Glu Val Thr Met Ser Tyr Pro Met Arg Ser Val 
    610                 615                 620                 


Gln His Arg His Phe Arg Leu Val His Asn Leu Asn Phe Lys Met Pro 
625                 630                 635                 640 


Phe Pro Ile Asp Gln Asp Phe Tyr Val Ser Pro Thr Phe Gln Asp Leu 
                645                 650                 655     


Leu Asn Arg Thr Thr Ala Gly Gln Pro Thr Gly Trp Tyr Lys Asp Leu 
            660                 665                 670         


Arg His Tyr Tyr Tyr Arg Ala Arg Trp Glu Leu Tyr Asp Arg Ser Arg 
        675                 680                 685             


Asp Pro His Glu Thr Gln Asn Leu Ala Thr Asp Pro Arg Phe Ala Gln 
    690                 695                 700                 


Leu Leu Glu Met Leu Arg Asp Gln Leu Ala Lys Trp Gln Trp Glu Thr 
705                 710                 715                 720 


His Asp Pro Trp Val Cys Ala Pro Asp Gly Val Leu Glu Glu Lys Leu 
                725                 730                 735     


Ser Pro Gln Cys Gln Pro Leu His Asn Glu Leu 
            740                 745         


<210>  10
<211>  738
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  10

Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu 
1               5                   10                  15      


Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala 
            20                  25                  30          


Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser 
        35                  40                  45              


Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His 
    50                  55                  60                  


Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser 
65                  70                  75                  80  


Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val 
                85                  90                  95      


Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr 
            100                 105                 110         


Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val 
        115                 120                 125             


Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln 
    130                 135                 140                 


Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro 
145                 150                 155                 160 


His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys 
                165                 170                 175     


Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro 
            180                 185                 190         


Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn 
        195                 200                 205             


Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly 
    210                 215                 220                 


Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala 
225                 230                 235                 240 


Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile 
                245                 250                 255     


Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu 
            260                 265                 270         


Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val 
        275                 280                 285             


Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp 
    290                 295                 300                 


Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr 
305                 310                 315                 320 


Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro 
                325                 330                 335     


Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met 
            340                 345                 350         


Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His 
        355                 360                 365             


Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val 
    370                 375                 380                 


Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro 
385                 390                 395                 400 


Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp 
                405                 410                 415     


Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala 
            420                 425                 430         


Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu 
        435                 440                 445             


Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp 
    450                 455                 460                 


Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn 
465                 470                 475                 480 


Glu Leu Pro Glu Pro Ile Val Arg Ile Val Gly Arg Asn Gly Leu Cys 
                485                 490                 495     


Val Asp Val Arg Asp Gly Arg Phe His Asn Gly Asn Ala Ile Gln Leu 
            500                 505                 510         


Trp Pro Cys Lys Ser Asn Thr Asp Ala Asn Gln Leu Trp Thr Leu Lys 
        515                 520                 525             


Arg Asp Asn Thr Ile Arg Ser Asn Gly Lys Cys Leu Thr Thr Tyr Gly 
    530                 535                 540                 


Tyr Ser Pro Gly Val Tyr Val Met Ile Tyr Asp Cys Asn Thr Ala Ala 
545                 550                 555                 560 


Thr Asp Ala Thr Arg Trp Gln Ile Trp Asp Asn Gly Thr Ile Ile Asn 
                565                 570                 575     


Pro Arg Ser Ser Leu Val Leu Ala Ala Thr Ser Gly Asn Ser Gly Thr 
            580                 585                 590         


Thr Leu Thr Val Gln Thr Asn Ile Tyr Ala Val Ser Gln Gly Trp Leu 
        595                 600                 605             


Pro Thr Asn Asn Thr Gln Pro Phe Val Thr Thr Ile Val Gly Leu Tyr 
    610                 615                 620                 


Gly Leu Cys Leu Gln Ala Asn Ser Gly Gln Val Trp Ile Glu Asp Cys 
625                 630                 635                 640 


Ser Ser Glu Lys Ala Glu Gln Gln Trp Ala Leu Tyr Ala Asp Gly Ser 
                645                 650                 655     


Ile Arg Pro Gln Gln Asn Arg Asp Asn Cys Leu Thr Ser Asp Ser Asn 
            660                 665                 670         


Ile Arg Glu Thr Val Val Lys Ile Leu Ser Cys Gly Pro Ala Ser Ser 
        675                 680                 685             


Gly Gln Arg Trp Met Phe Lys Asn Asp Gly Thr Ile Leu Asn Leu Tyr 
    690                 695                 700                 


Ser Gly Leu Val Leu Asp Val Arg Ala Ser Asp Pro Ser Leu Lys Gln 
705                 710                 715                 720 


Ile Ile Leu Tyr Pro Leu His Gly Asp Pro Asn Gln Ile Trp Leu Pro 
                725                 730                 735     


Leu Phe 
        


<210>  11
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  potatin signal sequence

<400>  11

Met Ala Ser Ser Ala Thr Thr Lys Ser Phe Leu Ile Leu Phe Phe Met 
1               5                   10                  15      


Ile Leu Ala Thr Thr Ser Ser Thr Cys Ala Val Asp 
            20                  25              


