                         SEQUENCE LISTING

<110>  Omeros Corporation
       University of Leicester
        
<120>  Compositions and Methods of Inhibiting MASP-1 and/or MASP-2 
       and/or MASP-3 for the Treatment of Paroxysmal Nocturnal 
       Hemoglobinuria

<130>  MP.1.0146.PCT

<150>  US 61/621,461
<151>  2012-04-06

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  725
<212>  DNA
<213>  homo sapiens

<400>  1
ggccaggcca gctggacggg cacaccatga ggctgctgac cctcctgggc cttctgtgtg       60

gctcggtggc cacccccttg ggcccgaagt ggcctgaacc tgtgttcggg cgcctggcat      120

cccccggctt tccaggggag tatgccaatg accaggagcg gcgctggacc ctgactgcac      180

cccccggcta ccgcctgcgc ctctacttca cccacttcga cctggagctc tcccacctct      240

gcgagtacga cttcgtcaag ctgagctcgg gggccaaggt gctggccacg ctgtgcgggc      300

aggagagcac agacacggag cgggcccctg gcaaggacac tttctactcg ctgggctcca      360

gcctggacat taccttccgc tccgactact ccaacgagaa gccgttcacg gggttcgagg      420

ccttctatgc agccgaggac attgacgagt gccaggtggc cccgggagag gcgcccacct      480

gcgaccacca ctgccacaac cacctgggcg gtttctactg ctcctgccgc gcaggctacg      540

tcctgcaccg taacaagcgc acctgctcag agcagagcct ctagcctccc ctggagctcc      600

ggcctgccca gcaggtcaga agccagagcc agcctgctgg cctcagctcc gggttgggct      660

gagatggctg tgccccaact cccattcacc caccatggac ccaataataa acctggcccc      720

acccc                                                                  725


<210>  2
<211>  185
<212>  PRT
<213>  homo sapiens

<400>  2

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Glu Gln Ser Leu 
            180                 185 


<210>  3
<211>  170
<212>  PRT
<213>  homo sapiens

<400>  3

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala 
1               5                   10                  15      


Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser 
                85                  90                  95      


Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln 
        115                 120                 125             


Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His 
    130                 135                 140                 


Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg 
145                 150                 155                 160 


Asn Lys Arg Thr Cys Ser Glu Gln Ser Leu 
                165                 170 


<210>  4
<211>  2460
<212>  DNA
<213>  homo sapiens

<400>  4
ggccagctgg acgggcacac catgaggctg ctgaccctcc tgggccttct gtgtggctcg       60

gtggccaccc ccttgggccc gaagtggcct gaacctgtgt tcgggcgcct ggcatccccc      120

ggctttccag gggagtatgc caatgaccag gagcggcgct ggaccctgac tgcacccccc      180

ggctaccgcc tgcgcctcta cttcacccac ttcgacctgg agctctccca cctctgcgag      240

tacgacttcg tcaagctgag ctcgggggcc aaggtgctgg ccacgctgtg cgggcaggag      300

agcacagaca cggagcgggc ccctggcaag gacactttct actcgctggg ctccagcctg      360

gacattacct tccgctccga ctactccaac gagaagccgt tcacggggtt cgaggccttc      420

tatgcagccg aggacattga cgagtgccag gtggccccgg gagaggcgcc cacctgcgac      480

caccactgcc acaaccacct gggcggtttc tactgctcct gccgcgcagg ctacgtcctg      540

caccgtaaca agcgcacctg ctcagccctg tgctccggcc aggtcttcac ccagaggtct      600

ggggagctca gcagccctga atacccacgg ccgtatccca aactctccag ttgcacttac      660

agcatcagcc tggaggaggg gttcagtgtc attctggact ttgtggagtc cttcgatgtg      720

gagacacacc ctgaaaccct gtgtccctac gactttctca agattcaaac agacagagaa      780

gaacatggcc cattctgtgg gaagacattg ccccacagga ttgaaacaaa aagcaacacg      840

gtgaccatca cctttgtcac agatgaatca ggagaccaca caggctggaa gatccactac      900

acgagcacag cgcagccttg cccttatccg atggcgccac ctaatggcca cgtttcacct      960

gtgcaagcca aatacatcct gaaagacagc ttctccatct tttgcgagac tggctatgag     1020

cttctgcaag gtcacttgcc cctgaaatcc tttactgcag tttgtcagaa agatggatct     1080

tgggaccggc caatgcccgc gtgcagcatt gttgactgtg gccctcctga tgatctaccc     1140

agtggccgag tggagtacat cacaggtcct ggagtgacca cctacaaagc tgtgattcag     1200

tacagctgtg aagagacctt ctacacaatg aaagtgaatg atggtaaata tgtgtgtgag     1260

gctgatggat tctggacgag ctccaaagga gaaaaatcac tcccagtctg tgagcctgtt     1320

tgtggactat cagcccgcac aacaggaggg cgtatatatg gagggcaaaa ggcaaaacct     1380

ggtgattttc cttggcaagt cctgatatta ggtggaacca cagcagcagg tgcactttta     1440

tatgacaact gggtcctaac agctgctcat gccgtctatg agcaaaaaca tgatgcatcc     1500

gccctggaca ttcgaatggg caccctgaaa agactatcac ctcattatac acaagcctgg     1560

tctgaagctg tttttataca tgaaggttat actcatgatg ctggctttga caatgacata     1620

gcactgatta aattgaataa caaagttgta atcaatagca acatcacgcc tatttgtctg     1680

ccaagaaaag aagctgaatc ctttatgagg acagatgaca ttggaactgc atctggatgg     1740

ggattaaccc aaaggggttt tcttgctaga aatctaatgt atgtcgacat accgattgtt     1800

gaccatcaaa aatgtactgc tgcatatgaa aagccaccct atccaagggg aagtgtaact     1860

gctaacatgc tttgtgctgg cttagaaagt gggggcaagg acagctgcag aggtgacagc     1920

ggaggggcac tggtgtttct agatagtgaa acagagaggt ggtttgtggg aggaatagtg     1980

tcctggggtt ccatgaattg tggggaagca ggtcagtatg gagtctacac aaaagttatt     2040

aactatattc cctggatcga gaacataatt agtgattttt aacttgcgtg tctgcagtca     2100

aggattcttc atttttagaa atgcctgtga agaccttggc agcgacgtgg ctcgagaagc     2160

attcatcatt actgtggaca tggcagttgt tgctccaccc aaaaaaacag actccaggtg     2220

aggctgctgt catttctcca cttgccagtt taattccagc cttacccatt gactcaaggg     2280

gacataaacc acgagagtga cagtcatctt tgcccaccca gtgtaatgtc actgctcaaa     2340

ttacatttca ttaccttaaa aagccagtct cttttcatac tggctgttgg catttctgta     2400

aactgcctgt ccatgctctt tgtttttaaa cttgttctta ttgaaaaaaa aaaaaaaaaa     2460


<210>  5
<211>  686
<212>  PRT
<213>  homo sapiens

<400>  5

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685     


<210>  6
<211>  671
<212>  PRT
<213>  homo sapiens

<400>  6

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala 
1               5                   10                  15      


Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser 
                85                  90                  95      


Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln 
        115                 120                 125             


Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His 
    130                 135                 140                 


Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg 
145                 150                 155                 160 


Asn Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln 
                165                 170                 175     


Arg Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val 
        195                 200                 205             


Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr 
    210                 215                 220                 


Leu Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser 
                245                 250                 255     


Asn Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro 
        275                 280                 285             


Met Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile 
    290                 295                 300                 


Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu 
305                 310                 315                 320 


Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro 
        355                 360                 365             


Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp 
385                 390                 395                 400 


Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu 
                405                 410                 415     


Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly 
            420                 425                 430         


Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu 
        435                 440                 445             


Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu 
    450                 455                 460                 


Thr Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu 
465                 470                 475                 480 


Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln 
                485                 490                 495     


Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala 
            500                 505                 510         


Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val 
        515                 520                 525             


Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu 
    530                 535                 540                 


Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu 
545                 550                 555                 560 


Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro 
                565                 570                 575     


Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr 
            580                 585                 590         


Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser 
        595                 600                 605             


Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe 
    610                 615                 620                 


Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp 
625                 630                 635                 640 


Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys 
                645                 650                 655     


Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
            660                 665                 670     


<210>  7
<211>  3895
<212>  DNA
<213>  homo sapiens

<400>  7
attccggcac agggacacaa acaagctcac ccaacaaagc caagctggga ggaccaaggc       60

cgggcagccg ggagcaccca aggcaggaaa atgaggtggc tgcttctcta ttatgctctg      120

tgcttctccc tgtcaaaggc ttcagcccac accgtggagc taaacaatat gtttggccag      180

atccagtcgc ctggttatcc agactcctat cccagtgatt cagaggtgac ttggaatatc      240

actgtcccag atgggtttcg gatcaagctt tacttcatgc acttcaactt ggaatcctcc      300

tacctttgtg aatatgacta tgtgaaggta gaaactgagg accaggtgct ggcaaccttc      360

tgtggcaggg agaccacaga cacagagcag actcccggcc aggaggtggt cctctcccct      420

ggctccttca tgtccatcac tttccggtca gatttctcca atgaggagcg tttcacaggc      480

tttgatgccc actacatggc tgtggatgtg gacgagtgca aggagaggga ggacgaggag      540

ctgtcctgtg accactactg ccacaactac attggcggct actactgctc ctgccgcttc      600

ggctacatcc tccacacaga caacaggacc tgccgagtgg agtgcagtga caacctcttc      660

actcaaagga ctggggtgat caccagccct gacttcccaa acccttaccc caagagctct      720

gaatgcctgt ataccatcga gctggaggag ggtttcatgg tcaacctgca gtttgaggac      780

atatttgaca ttgaggacca tcctgaggtg ccctgcccct atgactacat caagatcaaa      840

gttggtccaa aagttttggg gcctttctgt ggagagaaag ccccagaacc catcagcacc      900

cagagccaca gtgtcctgat cctgttccat agtgacaact cgggagagaa ccggggctgg      960

aggctctcat acagggctgc aggaaatgag tgcccagagc tacagcctcc tgtccatggg     1020

aaaatcgagc cctcccaagc caagtatttc ttcaaagacc aagtgctcgt cagctgtgac     1080

acaggctaca aagtgctgaa ggataatgtg gagatggaca cattccagat tgagtgtctg     1140

aaggatggga cgtggagtaa caagattccc acctgtaaaa ttgtagactg tagagcccca     1200

ggagagctgg aacacgggct gatcaccttc tctacaagga acaacctcac cacatacaag     1260

tctgagatca aatactcctg tcaggagccc tattacaaga tgctcaacaa taacacaggt     1320

atatatacct gttctgccca aggagtctgg atgaataaag tattggggag aagcctaccc     1380

acctgccttc cagagtgtgg tcagccctcc cgctccctgc caagcctggt caagaggatc     1440

attgggggcc gaaatgctga gcctggcctc ttcccgtggc aggccctgat agtggtggag     1500

gacacttcga gagtgccaaa tgacaagtgg tttgggagtg gggccctgct ctctgcgtcc     1560

tggatcctca cagcagctca tgtgctgcgc tcccagcgta gagacaccac ggtgatacca     1620

gtctccaagg agcatgtcac cgtctacctg ggcttgcatg atgtgcgaga caaatcgggg     1680

gcagtcaaca gctcagctgc ccgagtggtg ctccacccag acttcaacat ccaaaactac     1740

aaccacgata tagctctggt gcagctgcag gagcctgtgc ccctgggacc ccacgttatg     1800

cctgtctgcc tgccaaggct tgagcctgaa ggcccggccc cccacatgct gggcctggtg     1860

gccggctggg gcatctccaa tcccaatgtg acagtggatg agatcatcag cagtggcaca     1920

cggaccttgt cagatgtcct gcagtatgtc aagttacccg tggtgcctca cgctgagtgc     1980

aaaactagct atgagtcccg ctcgggcaat tacagcgtca cggagaacat gttctgtgct     2040

ggctactacg agggcggcaa agacacgtgc cttggagata gcggtggggc ctttgtcatc     2100

tttgatgact tgagccagcg ctgggtggtg caaggcctgg tgtcctgggg gggacctgaa     2160

gaatgcggca gcaagcaggt ctatggagtc tacacaaagg tctccaatta cgtggactgg     2220

gtgtgggagc agatgggctt accacaaagt gttgtggagc cccaggtgga acggtgagct     2280

gacttacttc ctcggggcct gcctcccctg agcgaagcta caccgcactt ccgacagcac     2340

actccacatt acttatcaga ccatatggaa tggaacacac tgacctagcg gtggcttctc     2400

ctaccgagac agcccccagg accctgagag gcagagtgtg gtatagggaa aaggctccag     2460

gcaggagacc tgtgttcctg agcttgtcca agtctctttc cctgtctggg cctcactcta     2520

ccgagtaata caatgcagga gctcaaccaa ggcctctgtg ccaatcccag cactcctttc     2580

caggccatgc ttcttacccc agtggccttt attcactcct gaccacttat caaacccatc     2640

ggtcctactg ttggtataac tgagcttgga cctgactatt agaaaatggt ttctaacatt     2700

gaactgaatg ccgcatctgt atattttcct gctctgcctt ctgggactag ccttggccta     2760

atccttcctc taggagaaga gcattcaggt tttgggagat ggctcatagc caagcccctc     2820

tctcttagtg tgatcccttg gagcaccttc atgcctgggg tttctctccc aaaagcttct     2880

tgcagtctaa gccttatccc ttatgttccc cattaaagga atttcaaaag acatggagaa     2940

agttgggaag gtttgtgctg actgctggga gcagaatagc cgtgggaggc ccaccaagcc     3000

cttaaattcc cattgtcaac tcagaacaca tttgggccca tatgccaccc tggaacacca     3060

gctgacacca tgggcgtcca cacctgctgc tccagacaag cacaaagcaa tctttcagcc     3120

ttgaaatgta ttatctgaaa ggctacctga agcccaggcc cgaatatggg gacttagtcg     3180

attacctgga aaaagaaaag acccacactg tgtcctgctg tgcttttggg caggaaaatg     3240

gaagaaagag tggggtgggc acattagaag tcacccaaat cctgccaggc tgcctggcat     3300

ccctggggca tgagctgggc ggagaatcca ccccgcagga tgttcagagg gacccactcc     3360

ttcatttttc agagtcaaag gaatcagagg ctcacccatg gcaggcagtg aaaagagcca     3420

ggagtcctgg gttctagtcc ctgctctgcc cccaactggc tgtataacct ttgaaaaatc     3480

attttctttg tctgagtctc tggttctccg tcagcaacag gctggcataa ggtcccctgc     3540

aggttccttc tagctggagc actcagagct tccctgactg ctagcagcct ctctggccct     3600

cacagggctg attgttctcc ttctccctgg agctctctct cctgaaaatc tccatcagag     3660

caaggcagcc agagaagccc ctgagaggga atgattggga agtgtccact ttctcaaccg     3720

gctcatcaaa cacactcctt tgtctatgaa tggcacatgt aaatgatgtt atattttgta     3780

tcttttatat catatgcttc accattctgt aaagggcctc tgcattgttg ctcccatcag     3840

gggtctcaag tggaaataaa ccctcgtgga taaccaaaaa aaaaaaaaaa aaaaa          3895


<210>  8
<211>  728
<212>  PRT
<213>  homo sapiens

<400>  8

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val Lys 
        435                 440                 445             


Arg Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln 
    450                 455                 460                 


Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp 
465                 470                 475                 480 


Phe Gly Ser Gly Ala Leu Leu Ser Ala Ser Trp Ile Leu Thr Ala Ala 
                485                 490                 495     


His Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile Pro Val Ser 
            500                 505                 510         


Lys Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys 
        515                 520                 525             


Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val Val Leu His Pro Asp 
    530                 535                 540                 


Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln 
545                 550                 555                 560 


Glu Pro Val Pro Leu Gly Pro His Val Met Pro Val Cys Leu Pro Arg 
                565                 570                 575     


Leu Glu Pro Glu Gly Pro Ala Pro His Met Leu Gly Leu Val Ala Gly 
            580                 585                 590         


Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser 
        595                 600                 605             


Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr Val Lys Leu Pro Val 
    610                 615                 620                 


Val Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn 
625                 630                 635                 640 


Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly 
                645                 650                 655     


Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Phe Asp 
            660                 665                 670         


Asp Leu Ser Gln Arg Trp Val Val Gln Gly Leu Val Ser Trp Gly Gly 
        675                 680                 685             


Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val 
    690                 695                 700                 


Ser Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Leu Pro Gln Ser 
705                 710                 715                 720 


Val Val Glu Pro Gln Val Glu Arg 
                725             


<210>  9
<211>  2852
<212>  DNA
<213>  homo sapiens

<400>  9
tggcgataca ttcacacagg aacagctatg ccatgtttac gaattccggt tttgaaaaaa       60

ctttcgttga cagttacaca aagggtcact tcctccccag cgacacatgg gcctctcaaa      120

ggagaggagg gagtaagtcc cacggtaggg ccagtggttg ctccctgggt tttggaatca      180

tttctgcgga gctttcaagg ccagaccctg ggcttagggt cgagacttta tagcagtgac      240

agccagaccc agcaagatgg ctgcgaccgt gaaaccctgg gcggcgatcc gggtgcgcat      300

catgagctga gagcgctggc tgttgccccg gtggaaggag tagaggccgt aggtgagggc      360

ggccgccgtg gccaggcaac ctatgggtac caccgggttc tcgcgggcaa gtcaagctgg      420

gaggaccaag gccgggcagc cgggagcacc caaggcagga aaatgaggtg gctgcttctc      480

tattatgctc tgtgcttctc cctgtcaaag gcttcagccc acaccgtgga gctaaacaat      540

atgtttggcc agatccagtc gcctggttat ccagactcct atcccagtga ttcagaggtg      600

acttggaata tcactgtccc agatgggttt cggatcaagc tttacttcat gcacttcaac      660

ttggaatcct cctacctttg tgaatatgac tatgtgaagg tagaaactga ggaccaggtg      720

ctggcaacct tctgtggcag ggagaccaca gacacagagc agactcccgg ccaggaggtg      780

gtcctctccc ctggctcctt catgtccatc actttccggt cagatttctc caatgaggag      840

cgtttcacag gctttgatgc ccactacatg gctgtggatg tggacgagtg caaggagagg      900

gaggacgagg agctgtcctg tgaccactac tgccacaact acattggcgg ctactactgc      960

tcctgccgct tcggctacat cctccacaca gacaacagga cctgccgagt ggagtgcagt     1020

gacaacctct tcactcaaag gactggggtg atcaccagcc ctgacttccc aaacccttac     1080

cccaagagct ctgaatgcct gtataccatc gagctggagg agggtttcat ggtcaacctg     1140

cagtttgagg acatatttga cattgaggac catcctgagg tgccctgccc ctatgactac     1200

atcaagatca aagttggtcc aaaagttttg gggcctttct gtggagagaa agccccagaa     1260

cccatcagca cccagagcca cagtgtcctg atcctgttcc atagtgacaa ctcgggagag     1320

aaccggggct ggaggctctc atacagggct gcaggaaatg agtgcccaga gctacagcct     1380

cctgtccatg ggaaaatcga gccctcccaa gccaagtatt tcttcaaaga ccaagtgctc     1440

gtcagctgtg acacaggcta caaagtgctg aaggataatg tggagatgga cacattccag     1500

attgagtgtc tgaaggatgg gacgtggagt aacaagattc ccacctgtaa aattgtagac     1560

tgtagagccc caggagagct ggaacacggg ctgatcacct tctctacaag gaacaacctc     1620

accacataca agtctgagat caaatactcc tgtcaggagc cctattacaa gatgctcaac     1680

aataacacag gtatatatac ctgttctgcc caaggagtct ggatgaataa agtattgggg     1740

agaagcctac ccacctgcct tccagtgtgt gggctcccca agttctcccg gaagctgatg     1800

gccaggatct tcaatggacg cccagcccag aaaggcacca ctccctggat tgccatgctg     1860

tcacacctga atgggcagcc cttctgcgga ggctcccttc taggctccag ctggatcgtg     1920

accgccgcac actgcctcca ccagtcactc gatccgaaag atccgaccct acgtgattca     1980

gacttgctca gcccttctga cttcaaaatc atcctgggca agcattggag gctccggtca     2040

gatgaaaatg aacagcatct cggcgtaaaa cacaccactc tccaccccaa gtatgatccc     2100

aacacattcg agaatgacgt ggctctggtg gagctgttgg agagcccagt gctgaatgcc     2160

ttcgtgatgc ccatctgtct gcctgaggga ccccagcagg aaggagccat ggtcatcgtc     2220

agcggctggg gaaagcagtt cttgcaaagg ttcccagaga ccctgatgga gattgaaatc     2280

ccgattgttg accacagcac ctgccagaag gcttatgccc cgctgaagaa gaaagtgacc     2340

agggacatga tctgtgctgg ggagaaggaa gggggaaagg acgcctgttc gggtgactct     2400

ggaggcccca tggtgaccct gaatagagaa agaggccagt ggtacctggt gggcactgtg     2460

tcctggggtg atgactgtgg gaagaaggac cgctacggag tatactctta catccaccac     2520

aacaaggact ggatccagag ggtcaccgga gtgaggaact gaatttggct cctcagcccc     2580

agcaccacca gctgtgggca gtcagtagca gaggacgatc ctccgatgaa agcagccatt     2640

tctcctttcc ttcctcccat cccccctcct tcggcctatc cattactggg caatagagca     2700

ggtatcttca cccccttttc actctcttta aagagatgga gcaagagagt ggtcagaaca     2760

caggccgaat ccaggctcta tcacttacta gttttcagtt ctgggcaggt gacttcatct     2820

cttcgaactt cagtttcttc ataagatgga aa                                   2852


<210>  10
<211>  699
<212>  PRT
<213>  homo sapiens

<400>  10

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Val Cys Gly Leu Pro Lys Phe Ser Arg Lys Leu Met Ala Arg 
        435                 440                 445             


Ile Phe Asn Gly Arg Pro Ala Gln Lys Gly Thr Thr Pro Trp Ile Ala 
    450                 455                 460                 


Met Leu Ser His Leu Asn Gly Gln Pro Phe Cys Gly Gly Ser Leu Leu 
465                 470                 475                 480 


Gly Ser Ser Trp Ile Val Thr Ala Ala His Cys Leu His Gln Ser Leu 
                485                 490                 495     


Asp Pro Lys Asp Pro Thr Leu Arg Asp Ser Asp Leu Leu Ser Pro Ser 
            500                 505                 510         


Asp Phe Lys Ile Ile Leu Gly Lys His Trp Arg Leu Arg Ser Asp Glu 
        515                 520                 525             


Asn Glu Gln His Leu Gly Val Lys His Thr Thr Leu His Pro Lys Tyr 
    530                 535                 540                 


Asp Pro Asn Thr Phe Glu Asn Asp Val Ala Leu Val Glu Leu Leu Glu 
545                 550                 555                 560 


Ser Pro Val Leu Asn Ala Phe Val Met Pro Ile Cys Leu Pro Glu Gly 
                565                 570                 575     


Pro Gln Gln Glu Gly Ala Met Val Ile Val Ser Gly Trp Gly Lys Gln 
            580                 585                 590         


Phe Leu Gln Arg Phe Pro Glu Thr Leu Met Glu Ile Glu Ile Pro Ile 
        595                 600                 605             


Val Asp His Ser Thr Cys Gln Lys Ala Tyr Ala Pro Leu Lys Lys Lys 
    610                 615                 620                 


Val Thr Arg Asp Met Ile Cys Ala Gly Glu Lys Glu Gly Gly Lys Asp 
625                 630                 635                 640 


Ala Cys Ser Gly Asp Ser Gly Gly Pro Met Val Thr Leu Asn Arg Glu 
                645                 650                 655     


Arg Gly Gln Trp Tyr Leu Val Gly Thr Val Ser Trp Gly Asp Asp Cys 
            660                 665                 670         


Gly Lys Lys Asp Arg Tyr Gly Val Tyr Ser Tyr Ile His His Asn Lys 
        675                 680                 685             


Asp Trp Ile Gln Arg Val Thr Gly Val Arg Asn 
    690                 695                 


<210>  11
<211>  380
<212>  PRT
<213>  homo sapiens

<400>  11

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Lys Asn Glu Ile Asp 
        355                 360                 365             


Leu Glu Ser Glu Leu Lys Ser Glu Gln Val Thr Glu 
    370                 375                 380 


<210>  12
<211>  2091
<212>  DNA
<213>  rattus

<400>  12
tggcacacaa tgaggctact gatcgtcctg ggtctgcttt ggagtttggt ggccacactt       60

ttgggctcca agtggcctga gcctgtattc gggcgcctgg tgtccctggc cttcccagag      120

aagtatggca accatcagga tcgatcctgg acgctgactg caccccctgg cttccgcctg      180

cgcctctact tcacccactt caacctggaa ctctcttacc gctgcgagta tgactttgtc      240

aagttgacct cagggaccaa ggtgctagcc acgctgtgtg ggcaggagag tacagatact      300

gagcgggcac ctggcaatga caccttctac tcactgggtc ccagcctaaa ggtcaccttc      360

cactccgact actccaatga gaagccattc acaggatttg aggccttcta tgcagcggag      420

gatgtggatg aatgcagaac atccctggga gactcagtcc cttgtgacca ttattgccac      480

aactacctgg gcggctacta ctgctcctgc cgagtgggct acattctgca ccagaacaag      540

catacctgct cagccctttg ttcaggccag gtgttcactg ggaggtctgg ctttctcagt      600

agccctgagt acccacagcc ataccccaaa ctctccagct gcgcctacaa catccgcctg      660

gaggaaggct tcagtatcac cctggacttc gtggagtcct ttgatgtgga gatgcaccct      720

gaagcccagt gcccctacga ctccctcaag attcaaacag acaagaggga atacggcccg      780

ttttgtggga agacgctgcc ccccaggatt gaaactgaca gcaacaaggt gaccattacc      840

tttaccaccg acgagtcagg gaaccacaca ggctggaaga tacactacac aagcacagca      900

cagccctgcc ctgatccaac ggcgccacct aatggtcaca tttcacctgt gcaagccacg      960

tatgtcctga aggacagctt ttctgtcttc tgcaagactg gcttcgagct tctgcaaggt     1020

tctgtccccc tgaagtcatt cactgctgtc tgtcagaaag atggatcttg ggaccggccg     1080

ataccagagt gcagcattat tgactgtggc cctcccgatg acctacccaa tggccacgtg     1140

gactatatca caggccctga agtgaccacc tacaaagctg tgattcagta cagctgtgaa     1200

gagactttct acacaatgag cagcaatggt aaatatgtgt gtgaggctga tggattctgg     1260

acgagctcca aaggagaaaa atccctcccg gtttgcaagc ctgtctgtgg actgtccaca     1320

cacacttcag gaggccgtat aattggagga cagcctgcaa agcctggtga ctttccttgg     1380

caagtcttgt tactgggtga aactacagca gcaggtgctc ttatacatga cgactgggtc     1440

ctaacagcgg ctcatgctgt atatgggaaa acagaggcga tgtcctccct ggacatccgc     1500

atgggcatcc tcaaaaggct ctccctcatt tacactcaag cctggccaga ggctgtcttt     1560

atccatgaag gctacactca cggagctggt tttgacaatg atatagcact gattaaactc     1620

aagaacaaag tcacaatcaa cagaaacatc atgccgattt gtctaccaag aaaagaagct     1680

gcatccttaa tgaaaacaga cttcgttgga actgtggctg gctgggggtt aacccagaag     1740

gggtttcttg ctagaaacct aatgtttgtg gacataccaa ttgttgacca ccaaaaatgt     1800

gctactgcgt atacaaagca gccctaccca ggagcaaaag tgactgttaa catgctctgt     1860

gctggcctag accgcggtgg caaggacagc tgcagaggtg acagcggagg ggcattagtg     1920

tttctagaca atgaaacaca gagatggttt gtgggaggaa tagtttcctg gggttctatt     1980

aactgtgggg ggtcagaaca gtatggggtc tacacgaaag tcacgaacta tattccctgg     2040

attgagaaca taataaataa tttctaattt gcaaaaaaaa aaaaaaaaaa a              2091


<210>  13
<211>  685
<212>  PRT
<213>  rattus

<400>  13

Met Arg Leu Leu Ile Val Leu Gly Leu Leu Trp Ser Leu Val Ala Thr 
1               5                   10                  15      


Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val Ser 
            20                  25                  30          


Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu Thr 
65                  70                  75                  80  


Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro Ser 
            100                 105                 110         


Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg Thr 
    130                 135                 140                 


Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr Leu 
145                 150                 155                 160 


Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His Gln Asn 
                165                 170                 175     


Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly Arg 
            180                 185                 190         


Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser Ile Thr 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu Ala Gln 
225                 230                 235                 240 


Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu Tyr Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser Asn 
            260                 265                 270         


Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp Pro Thr 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr Val Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu Gln 
                325                 330                 335     


Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro Glu 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly Phe 
                405                 410                 415     


Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys Pro Val 
            420                 425                 430         


Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly Gly Gln 
        435                 440                 445             


Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly Glu 
    450                 455                 460                 


Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu Thr Ala 
465                 470                 475                 480 


Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu Asp Ile 
                485                 490                 495     


Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln Ala Trp 
            500                 505                 510         


Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly Phe 
        515                 520                 525             


Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile Asn 
    530                 535                 540                 


Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala Ser Leu 
545                 550                 555                 560 


Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu Thr Gln 
                565                 570                 575     


Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile Val 
            580                 585                 590         


Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr Pro Gly 
        595                 600                 605             


Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg Gly Gly 
    610                 615                 620                 


Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu Asp 
625                 630                 635                 640 


Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly Ser 
                645                 650                 655     


Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys Val Thr 
            660                 665                 670         


Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe 
        675                 680                 685 


<210>  14
<211>  354
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  14
caggtcacct tgaaggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcagc aggggtaaaa tgggtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacacattt tttcgagtga cgaaaaatcc      180

tacaggacat cgctgaagag caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

cgacgtggag gaattgacta ctggggccag ggaaccctgg tcactgtctc ctca            354


<210>  15
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  15

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Thr 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  17

Gln Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Lys Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  18
<211>  324
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  18
tcctatgagc tgatacagcc accctcggtg tcagtggccc caggacagac ggccaccatt       60

acctgtgcgg gagacaacct tgggaagaaa cgtgtgcact ggtaccagca gaggccaggc      120

caggcccctg tgttggtcat ctatgatgat agcgaccggc cctcagggat ccctgaccga      180

ttctctgcct ccaactctgg gaacacggcc accctgacca tcactagggg cgaagccggg      240

gatgaggccg actattattg tcaggtgtgg gacattgcta ctgatcatgt ggtcttcggc      300

ggagggacca agctcaccgt ccta                                             324


<210>  19
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  19

Ser Tyr Glu Leu Ile Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ala Gly Asp Asn Leu Gly Lys Lys Arg Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Arg Gly Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ala Thr Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly 
            100                 105                 110         


Ser Glu Gln Lys Leu Ile Ser Glu 
        115                 120 


<210>  20
<211>  262
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  20

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Thr 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr 
    130                 135                 140                 


Glu Leu Ile Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala 
145                 150                 155                 160 


Thr Ile Thr Cys Ala Gly Asp Asn Leu Gly Lys Lys Arg Val His Trp 
                165                 170                 175     


Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Asp 
            180                 185                 190         


Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Thr Arg Gly Glu Ala Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ala Thr Asp His Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly Ser Glu 
                245                 250                 255     


Gln Lys Leu Ile Ser Glu 
            260         


<210>  21
<211>  245
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  21

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys 
        115                 120                 125             


Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Pro Val Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr Gln Asp Lys Gln Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
        195                 200                 205             


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  22
<211>  750
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  22
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaccagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagatcctt tcggggtacc ttttgatatc tggggccaag ggacaatggt caccgtctct      360

tcaaagcttt cagggagtgc atccgcccca aaacttgaag aaggtgaatt ttcagaagca      420

cgcgtatcct atgagctgat acagccaccc tcggtgtcag tggccccagg acagacggcc      480

accattacct gtgcgggaga caaccttggg aagaaacgtg tgcactggta ccagcagagg      540

ccaggccagg cccctgtgtt ggtcatctat gatgatagcg accggccctc agggatccct      600

gaccgattct ctgcctccaa ctctgggaac acggccaccc tgaccatcac taggggcgaa      660

gccggggatg aggccgacta ttattgtcag gtgtgggaca ttgctactga tcatgtggtc      720

ttcggcggag ggaccaagct caccgtccta                                       750


<210>  23
<211>  735
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (663)..(663)
<223>  n is a, c, g, or t

<400>  23
caggtcacct tgaaggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcagc aggggtaaaa tgggtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacacattt tttcgagtga cgaaaaatcc      180

tacaggacat cgctgaagag caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

cgacgtggag gaattgacta ctggggccag ggaaccctgg tcactgtctc ctcaaagctt      360

tcagggagtg catccgcccc aaaacttgaa gaaggtgaat tttcagaagc acgcgtacag      420

ccagtgctga ctcagccccc ctcactgtcc gtgtccccag gacagacagc cagcatcacc      480

tgctctggag agaaattggg ggataaatat gcttactggt atcagcagaa gccaggccag      540

tcccctgtgt tggtcatgta tcaagataaa cagcggccct cagggatccc tgagcgattc      600

tctggctcca actctgggaa cacagccact ctgaccatca gcgggaccca ggctatggat      660

gangctgact attactgtca ggcgtgggac agcagcactg cggtattcgg cggagggacc      720

aagctgaccg tccta                                                       735


<210>  24
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  24

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Asp Asp Gly Ser Gly Thr Arg Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile 
            100                 105                 110         


Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  25
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  25

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Arg Ser Asp Gly Ser Phe Thr Leu Tyr Ala Thr Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser Gly Asn Val Gly Asp Ile Asp Ala Trp Gly His Gly Thr 
            100                 105                 110         


Glu Val Ile Val Ser Ser 
        115             


<210>  26
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  26

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Phe Gly Asn Ser Thr Gly His Gly Ala Ala Val 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Arg Asp Asp Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Ser Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Val Tyr Gly Tyr Cys Gly Ser Tyr Ser Cys Cys Gly Val 
            100                 105                 110         


Asp Thr Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125             


<210>  27
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  27

Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile 
        35                  40                  45              


Tyr Asp Asn Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala 
65                  70                  75                  80  


Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  28
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  28

Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Tyr Ser Gly Tyr Ala Gly Ser Tyr Tyr 
            20                  25                  30          


Tyr Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu 
        35                  40                  45              


Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg 
65                  70                  75                  80  


Ala Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly 
                85                  90                  95      


Ala Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105             


<210>  29
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  29

Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala 
65                  70                  75                  80  


Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  30
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  30

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Lys Ser Gly Ala Gly Thr Asn Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Thr Gly Ser Gly Cys Ser Ser Gly Tyr Arg Ala Glu Tyr 
            100                 105                 110         


Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125     


<210>  31
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  31

Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala 
65                  70                  75                  80  


Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  32
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  32

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Arg Asn Asp Gly Arg Tyr Thr Glu Tyr Gly Ser Ala 
    50                  55                  60                  


Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val 
65                  70                  75                  80  


Arg Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ala Gly Gly Ser Ala Tyr Trp Phe Asp Ala Gly Gln 
            100                 105                 110         


Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125     


<210>  33
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  33

Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala 
65                  70                  75                  80  


Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  34
<211>  36
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  34

Leu Glu Val Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn 
1               5                   10                  15      


Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Phe Cys Thr Arg Lys 
            20                  25                  30          


Leu Cys Tyr Gln 
        35      


<210>  35
<211>  36
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  35

Leu Glu Val Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn 
1               5                   10                  15      


Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Val Cys Thr Lys Leu 
            20                  25                  30          


Trp Cys Asn Gln 
        35      


<210>  36
<211>  227
<212>  PRT
<213>  homo sapiens

<400>  36

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  37
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  37

Gly Thr Gly Gly Gly Ser Gly Ser Ser Ser Arg Ser 
1               5                   10          


<210>  38
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  38

Gly Thr Gly Gly Gly Ser Gly Ser Ser Ser 
1               5                   10  


<210>  39
<211>  888
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  39
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ctcgaggtga catgtgaacc cggtacgacg tttaaggata agtgcaacac atgtaggtgc      120

ggtagcgacg gcaaatcagc gttctgtacc cggaaattgt gctaccaggg aactggagga      180

gggtcggggt cctcgtcaag atctgacaaa actcacacat gcccaccgtg cccagcacct      240

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      300

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      360

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      420

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      480

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      540

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      600

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      660

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      720

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      780

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca cgaggctctg      840

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                   888


<210>  40
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  40

Leu Glu Val Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn 
1               5                   10                  15      


Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Phe Cys Thr Arg Lys 
            20                  25                  30          


Leu Cys Tyr Gln Gly Thr Gly Gly Gly Ser Gly Ser Ser Ser Arg Ser 
        35                  40                  45              


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                85                  90                  95      


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Lys 
        275 


<210>  41
<211>  888
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  41
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ttggaagtga cgtgtgagcc cggaacgaca ttcaaagaca agtgcaatac ttgtcggtgc      120

ggttcagatg ggaaatcggc ggtctgcaca aagctctggt gtaaccaggg caccggtgga      180

gggtcgggat ccagctcaag atctgacaaa actcacacat gcccaccgtg cccagcacct      240

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      300

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      360

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      420

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      480

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      540

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      600

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      660

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      720

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      780

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca cgaggctctg      840

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                   888


<210>  42
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  42

Leu Glu Val Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn 
1               5                   10                  15      


Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Val Cys Thr Lys Leu 
            20                  25                  30          


Trp Cys Asn Gln Gly Thr Gly Gly Gly Ser Gly Ser Ser Ser Arg Ser 
        35                  40                  45              


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                85                  90                  95      


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Lys 
        275 


