
                                SEQUENCE LISTING

<110> Lu, Yuan
      Swartz, James

<120> Influenza Vaccine Constructs
  

<130> STAN-961WO

<150> 61/650,933          
<151> 2012-05-23  

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 566
<212> PRT
<213> Influenza virus

<220> 
<221> DOMAIN         
<222> 1, 17-58, 292-520
<223> Stem domain

<400> 1
Met Lys Ala Ile Leu Val Val Met Leu Tyr Thr Phe Ala Thr Ala Asn
 1               5                  10                  15      
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
            20                  25                  30          
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
        35                  40                  45              
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val
    50                  55                  60                  
Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly
65                  70                  75                  80  
Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile
                85                  90                  95      
Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe
            100                 105                 110         
Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe
        115                 120                 125             
Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp
    130                 135                 140                 
Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser
145                 150                 155                 160 
Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro
                165                 170                 175     
Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val
            180                 185                 190         
Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu
        195                 200                 205             
Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser
    210                 215                 220                 
Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln
225                 230                 235                 240 
Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys
                245                 250                 255     
Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe
            260                 265                 270         
Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro
        275                 280                 285             
Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn
    290                 295                 300                 
Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys
305                 310                 315                 320 
Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg
                325                 330                 335     
Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly
            340                 345                 350         
Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr
        355                 360                 365             
His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser
    370                 375                 380                 
Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile
385                 390                 395                 400 
Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His
                405                 410                 415     
Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe
            420                 425                 430         
Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn
        435                 440                 445             
Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu
    450                 455                 460                 
Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly
465                 470                 475                 480 
Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val
                485                 490                 495     
Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu
            500                 505                 510         
Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr
        515                 520                 525             
Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val
    530                 535                 540                 
Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu
545                 550                 555                 560 
Gln Cys Arg Ile Cys Ile
                565     


<210> 2
<211> 272
<212> PRT
<213> Influenza virus

<400> 2
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Cys Asn Thr Thr Cys
        35                  40                  45              
Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu Pro Phe Gln Asn Ile
    50                  55                  60                  
His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr Val Lys Ser Thr Lys
65                  70                  75                  80  
Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser Ile Gln Ser Arg
                85                  90                  95      
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly
            100                 105                 110         
Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser
        115                 120                 125             
Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp Glu Ile
    130                 135                 140                 
Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr
145                 150                 155                 160 
Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys Arg Ile Glu Asn Leu
                165                 170                 175     
Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala
            180                 185                 190         
Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr His Asp
        195                 200                 205             
Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Ser Gln Leu Lys Asn
    210                 215                 220                 
Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys
225                 230                 235                 240 
Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro
                245                 250                 255     
Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Glu Ile Asp Gly Val
            260                 265                 270         


<210> 3
<211> 272
<212> PRT
<213> Influzuenza virus

<400> 3
Met Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln
 1               5                  10                  15      
Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp
            20                  25                  30          
Ile Leu Glu Lys Lys His Asn Gly Lys Leu Cys Cys Asn Thr Lys Cys
        35                  40                  45              
Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile
    50                  55                  60                  
His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Arg
65                  70                  75                  80  
Leu Val Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Arg Glu Thr Arg
                85                  90                  95      
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly
            100                 105                 110         
Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser
        115                 120                 125             
Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val
    130                 135                 140                 
Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu
145                 150                 155                 160 
Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu
                165                 170                 175     
Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala
            180                 185                 190         
Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp
        195                 200                 205             
Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp
    210                 215                 220                 
Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys
225                 230                 235                 240 
Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro
                245                 250                 255     
Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val
            260                 265                 270         


<210> 4
<211> 281
<212> PRT
<213> Influenza virus

<400> 4
Met Asp Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly
 1               5                  10                  15      
His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asp Asp
            20                  25                  30          
Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr
        35                  40                  45              
Gly Lys Ile Cys Cys Ile Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile
    50                  55                  60                  
Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala
65                  70                  75                  80  
Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met
                85                  90                  95      
Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Leu Phe Gly Ala Ile Ala
            100                 105                 110         
Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly
        115                 120                 125             
Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys
    130                 135                 140                 
Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val
145                 150                 155                 160 
Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser
                165                 170                 175     
Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr
            180                 185                 190         
Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu
        195                 200                 205             
Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe
    210                 215                 220                 
Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn
225                 230                 235                 240 
Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser
                245                 250                 255     
Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu
            260                 265                 270         
Asn Asn Arg Phe Gln Ile Lys Gly Val
        275                 280     


<210> 5
<211> 272
<212> PRT
<213> Influenza virus

<400> 5
Met Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Lys
 1               5                  10                  15      
Val Asp Thr Ile Leu Glu Arg Asn Val Thr Val Thr His Ala Lys Asp
            20                  25                  30          
Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Cys Glu Thr Lys Cys
        35                  40                  45              
Gln Thr Pro Leu Gly Ala Ile Asn Thr Thr Leu Pro Phe His Asn Val
    50                  55                  60                  
His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Glu Lys
65                  70                  75                  80  
Leu Val Leu Ala Thr Gly Leu Arg Asn Val Pro Gln Ile Glu Ser Arg
                85                  90                  95      
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly
            100                 105                 110         
Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Asp Gln Gly Ser
        115                 120                 125             
Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Phe Asp Gly Ile
    130                 135                 140                 
Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Glu
145                 150                 155                 160 
Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Arg Arg Leu Glu Asn Leu
                165                 170                 175     
Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala
            180                 185                 190         
Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp
        195                 200                 205             
Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Met Gln Leu Arg Asp
    210                 215                 220                 
Asn Val Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys
225                 230                 235                 240 
Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro
                245                 250                 255     
Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val
            260                 265                 270         


<210> 6
<211> 272
<212> PRT
<213> Influenza virus

<400> 6
Met Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Cys Asn Thr Lys Cys
        35                  40                  45              
Gln Thr Pro Leu Gly Ala Ile Asn Ser Ser Leu Pro Tyr Gln Asn Ile
    50                  55                  60                  
His Pro Val Thr Ile Gly Glu Cys Pro Lys Tyr Val Arg Ser Ala Lys
65                  70                  75                  80  
Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg
                85                  90                  95      
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly
            100                 105                 110         
Met Ile Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser
        115                 120                 125             
Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile
    130                 135                 140                 
Thr Asn Lys Val Asn Thr Val Ile Glu Lys Met Asn Ile Gln Phe Thr
145                 150                 155                 160 
Ala Val Gly Lys Glu Phe Asn Lys Leu Glu Lys Arg Met Glu Asn Leu
                165                 170                 175     
Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala
            180                 185                 190         
Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp
        195                 200                 205             
Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn
    210                 215                 220                 
Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys
225                 230                 235                 240 
Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro
                245                 250                 255     
Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Val Asp Gly Val
            260                 265                 270         


<210> 7
<211> 272
<212> PRT
<213> Influenza virus

<400> 7
Met Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Cys Asn Thr Lys Cys
        35                  40                  45              
Gln Thr Pro His Gly Ala Ile Asn Ser Ser Leu Pro Phe Gln Asn Ile
    50                  55                  60                  
His Pro Val Thr Ile Gly Glu Cys Pro Lys Tyr Val Arg Ser Thr Lys
65                  70                  75                  80  
Leu Arg Met Ala Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg
                85                  90                  95      
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly
            100                 105                 110         
Met Ile Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser
        115                 120                 125             
Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asp Gly Ile
    130                 135                 140                 
Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr
145                 150                 155                 160 
Ala Val Gly Lys Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu
                165                 170                 175     
Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala
            180                 185                 190         
Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp
        195                 200                 205             
Ser Asn Val Arg Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn
    210                 215                 220                 
Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys
225                 230                 235                 240 
Asp Asp Ala Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro
                245                 250                 255     
Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Glu Ile Asp Gly Val
            260                 265                 270         


<210> 8
<211> 308
<212> PRT
<213> Influenza virus

<220> 
<221> DOMAIN         
<222> (1)...(277)
<223> HA stem domain

<220> 
<221> DOMAIN         
<222> (278)...(284)
<223> TEV protease cleavage site

<220> 
<221> DOMAIN         
<222> (285)...(314)
<223> Foldon domain

<400> 8
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Cys Asn Thr Thr Cys
        35                  40                  45              
Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu Pro Phe Gln Asn Ile
    50                  55                  60                  
His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr Val Lys Ser Thr Lys
65                  70                  75                  80  
Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser Ile Gln Ser Arg
                85                  90                  95      
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly
            100                 105                 110         
Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser
        115                 120                 125             
Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp Glu Ile
    130                 135                 140                 
Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr
145                 150                 155                 160 
Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys Arg Ile Glu Asn Leu
                165                 170                 175     
Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala
            180                 185                 190         
Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr His Asp
        195                 200                 205             
Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Ser Gln Leu Lys Asn
    210                 215                 220                 
Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys
225                 230                 235                 240 
Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro
                245                 250                 255     
Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Glu Ile Asp Gly Val
            260                 265                 270         
Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val
        275                 280                 285             
Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His
    290                 295                 300                 
His His His His
305             


<210> 9
<211> 963
<212> DNA
<213> Influenza virus

<400> 9
atggataccc tctgcattgg ttaccacgcg aacaactcca ccgataccgt tgacactgtt 60
ctcgaaaaga acgtgaccgt gactcactct gtgaacctgc tggaagacaa acataacggt 120
aagctttgcg gttctggctc tggttgcaat actacctgcc agaccccgaa aggcgccatt 180
aacacctctc tcccattcca gaacatccat ccaatcacca ttggcaagtg tccaaagtat 240
gttaagtcta ccaaactccg cctggctacc ggtctgcgca atgttccgtc tattcagtcc 300
cgtggtctgt tcggcgctat tgctggcttc atcgagggcg gctggactgg tatggttgac 360
ggctggtacg gctaccatca ccagaacgaa caaggctctg gctatgcggc ggacctgaaa 420
tctactcaaa atgctatcga cgaaatcact aataaggtta attccgtgat cgaaaaaatg 480
aatactcagg acactgcggt tggtaaagaa ttcaaccacg acgagaagcg tattgagaat 540
ctgaacaaaa aagtggacga cggttttctc gacatctgga cctataacgc ggaactgctc 600
gtgctcctgg agaatgaacg taccctggat taccatgatt ctaatgtgaa gaatctctat 660
gagaaagttc gctctcagct caaaaacaat gcgaaagaaa tcggtaatgg ttgcttcgaa 720
ttctaccaca aatgtgacaa tacctgcatg gaatccgtta agaacggtac ctacgactac 780
ccaaaatact ctgaagaagc gaaactgaac cgcgaagaga tcgatggcgt ggaaaacctg 840
tacttccagt ctggttctgg ttacatcccg gaagctccgc gtgacggtca ggcgtacgtt 900
cgtaaagacg gtgaatgggt tctgctgtct accttcctgg gtcaccacca tcatcaccac 960
taa                                                               963

<210> 10
<211> 320
<212> PRT
<213> Influenza virus

<400> 10
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Gly Ser Gly Ser Gly
        35                  40                  45              
Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu
    50                  55                  60                  
Pro Phe Gln Asn Thr His Pro Glu Thr Thr Gly Lys Thr Pro Lys Tyr
65                  70                  75                  80  
Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro
                85                  90                  95      
Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu
            100                 105                 110         
Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln
        115                 120                 125             
Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn
    130                 135                 140                 
Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met
145                 150                 155                 160 
Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys
                165                 170                 175     
Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile
            180                 185                 190         
Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr
        195                 200                 205             
Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg
    210                 215                 220                 
Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu
225                 230                 235                 240 
Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly
                245                 250                 255     
Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu
            260                 265                 270         
Glu Ile Asp Gly Val Glu Asn Leu Tyr Phe Gln Ser Gly Ser Gly Tyr
        275                 280                 285             
Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly
    290                 295                 300                 
Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His His
305                 310                 315                 320 


<210> 11
<211> 320
<212> PRT
<213> Influenza virus

<400> 11
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Gly Ser Gly Ser Gly
        35                  40                  45              
Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu
    50                  55                  60                  
Pro Phe Gln Asn Thr His Pro Glu Thr Thr Gly Lys Thr Pro Lys Tyr
65                  70                  75                  80  
Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro
                85                  90                  95      
Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu
            100                 105                 110         
Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln
        115                 120                 125             
Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn
    130                 135                 140                 
Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met
145                 150                 155                 160 
Asn Thr Gln Asp Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys
                165                 170                 175     
Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile
            180                 185                 190         
Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr
        195                 200                 205             
Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg
    210                 215                 220                 
Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu
225                 230                 235                 240 
Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly
                245                 250                 255     
Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu
            260                 265                 270         
Glu Ile Asp Gly Val Glu Asn Leu Tyr Phe Gln Ser Gly Ser Gly Tyr
        275                 280                 285             
Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly
    290                 295                 300                 
Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His His
305                 310                 315                 320 


<210> 12
<211> 320
<212> PRT
<213> Influenza virus

<400> 12
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Gly Ser Gly Ser Gly
        35                  40                  45              
Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu
    50                  55                  60                  
Pro Phe Gln Asn Thr His Pro Glu Thr Thr Gly Lys Thr Pro Lys Tyr
65                  70                  75                  80  
Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro
                85                  90                  95      
Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu
            100                 105                 110         
Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln
        115                 120                 125             
Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn
    130                 135                 140                 
Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met
145                 150                 155                 160 
Asn Thr Gln Asp Thr Ala Val Gly Lys Glu Phe Asn His Asp Glu Lys
                165                 170                 175     
Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile
            180                 185                 190         
Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr
        195                 200                 205             
Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg
    210                 215                 220                 
Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu
225                 230                 235                 240 
Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly
                245                 250                 255     
Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu
            260                 265                 270         
Glu Ile Asp Gly Val Glu Asn Leu Tyr Phe Gln Ser Gly Ser Gly Tyr
        275                 280                 285             
Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly
    290                 295                 300                 
Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His His
305                 310                 315                 320 


<210> 13
<211> 320
<212> PRT
<213> Influenza virus

<400> 13
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Gly Ser Gly Ser Gly
        35                  40                  45              
Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu
    50                  55                  60                  
Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr
65                  70                  75                  80  
Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro
                85                  90                  95      
Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu
            100                 105                 110         
Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln
        115                 120                 125             
Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn
    130                 135                 140                 
Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met
145                 150                 155                 160 
Asn Thr Gln Asp Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys
                165                 170                 175     
Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile
            180                 185                 190         
Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr
        195                 200                 205             
Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg
    210                 215                 220                 
Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu
225                 230                 235                 240 
Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly
                245                 250                 255     
Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu
            260                 265                 270         
Glu Ile Asp Gly Val Glu Asn Leu Tyr Phe Gln Ser Gly Ser Gly Tyr
        275                 280                 285             
Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly
    290                 295                 300                 
Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His His
305                 310                 315                 320 


<210> 14
<211> 320
<212> PRT
<213> Influenza virus

<400> 14
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Gly Ser Gly Ser Gly
        35                  40                  45              
Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu
    50                  55                  60                  
Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr
65                  70                  75                  80  
Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro
                85                  90                  95      
Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu
            100                 105                 110         
Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln
        115                 120                 125             
Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn
    130                 135                 140                 
Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met
145                 150                 155                 160 
Asn Thr Gln Asp Thr Ala Val Gly Lys Glu Phe Asn His Asp Glu Lys
                165                 170                 175     
Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile
            180                 185                 190         
Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr
        195                 200                 205             
Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg
    210                 215                 220                 
Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu
225                 230                 235                 240 
Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly
                245                 250                 255     
Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu
            260                 265                 270         
Glu Ile Asp Gly Val Glu Asn Leu Tyr Phe Gln Ser Gly Ser Gly Tyr
        275                 280                 285             
Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly
    290                 295                 300                 
Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His His
305                 310                 315                 320 


<210> 15
<211> 320
<212> PRT
<213> Influenza virus

<400> 15
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Gly Ser Gly Ser Gly
        35                  40                  45              
Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu
    50                  55                  60                  
Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr
65                  70                  75                  80  
Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro
                85                  90                  95      
Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu
            100                 105                 110         
Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln
        115                 120                 125             
Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn
    130                 135                 140                 
Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met
145                 150                 155                 160 
Asn Thr Gln Asp Thr Ala Val Gly Lys Glu Phe Asn His Asp Glu Lys
                165                 170                 175     
Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile
            180                 185                 190         
Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr
        195                 200                 205             
Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg
    210                 215                 220                 
Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu
225                 230                 235                 240 
Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly
                245                 250                 255     
Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu
            260                 265                 270         
Glu Ile Asp Gly Val Glu Asn Leu Tyr Phe Gln Ser Gly Ser Gly Tyr
        275                 280                 285             
Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly
    290                 295                 300                 
Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His His
305                 310                 315                 320 


<210> 16
<211> 301
<212> PRT
<213> Influenza virus

<400> 16
Met Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr
 1               5                  10                  15      
Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn
            20                  25                  30          
Leu Leu Glu Asp Lys Gly Ser Gly Ser Gly Thr Ser Leu Pro Phe Gln
        35                  40                  45              
Asn Ile His Pro Ile Thr Ile Gly Lys Thr Pro Lys Tyr Val Lys Ser
    50                  55                  60                  
Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser Ile Gln
65                  70                  75                  80  
Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp
                85                  90                  95      
Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln
            100                 105                 110         
Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp
        115                 120                 125             
Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln
    130                 135                 140                 
Asp Thr Ala Val Gly Lys Glu Phe Asn His Asp Glu Lys Arg Ile Glu
145                 150                 155                 160 
Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr
                165                 170                 175     
Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr
            180                 185                 190         
His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Ser Gln Leu
        195                 200                 205             
Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His
    210                 215                 220                 
Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp
225                 230                 235                 240 
Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Glu Ile Asp
                245                 250                 255     
Gly Val Glu Asn Leu Tyr Phe Gln Ser Gly Ser Gly Tyr Ile Pro Glu
            260                 265                 270         
Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val
        275                 280                 285             
Leu Leu Ser Thr Phe Leu Gly His His His His His His
    290                 295                 300     

