                                     SEQUENCE LISTING

<110> VALERION THERAPEUTICS, INC.
 
<120> METHODS FOR INCREASING MUSCLE CONTRACTILITY

<130> 106199-0019-WO1

<140>
<141>

<150> 61/729,160
<151> 2012-11-21

<150> 61/650,899
<151> 2012-05-23

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 603
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Ser Ala Ser Thr Ser Lys Tyr Asn Ser His Ser Leu Glu Asn 
1               5                   10                  15      


Glu Ser Ile Lys Arg Thr Ser Arg Asp Gly Val Asn Arg Asp Leu Thr 
            20                  25                  30          


Glu Ala Val Pro Arg Leu Pro Gly Glu Thr Leu Ile Thr Asp Lys Glu 
        35                  40                  45              


Val Ile Tyr Ile Cys Pro Phe Asn Gly Pro Ile Lys Gly Arg Val Tyr 
    50                  55                  60                  


Ile Thr Asn Tyr Arg Leu Tyr Leu Arg Ser Leu Glu Thr Asp Ser Ser 
65                  70                  75                  80  


Leu Ile Leu Asp Val Pro Leu Gly Val Ile Ser Arg Ile Glu Lys Met 
                85                  90                  95      


Gly Gly Ala Thr Ser Arg Gly Glu Asn Ser Tyr Gly Leu Asp Ile Thr 
            100                 105                 110         


Cys Lys Asp Met Arg Asn Leu Arg Phe Ala Leu Lys Gln Glu Gly His 
        115                 120                 125             


Ser Arg Arg Asp Met Phe Glu Ile Leu Thr Arg Tyr Ala Phe Pro Leu 
    130                 135                 140                 


Ala His Ser Leu Pro Leu Phe Ala Phe Leu Asn Glu Glu Lys Phe Asn 
145                 150                 155                 160 


Val Asp Gly Trp Thr Val Tyr Asn Pro Val Glu Glu Tyr Arg Arg Gln 
                165                 170                 175     


Gly Leu Pro Asn His His Trp Arg Ile Thr Phe Ile Asn Lys Cys Tyr 
            180                 185                 190         


Glu Leu Cys Asp Thr Tyr Pro Ala Leu Leu Val Val Pro Tyr Arg Ala 
        195                 200                 205             


Ser Asp Asp Asp Leu Arg Arg Val Ala Thr Phe Arg Ser Arg Asn Arg 
    210                 215                 220                 


Ile Pro Val Leu Ser Trp Ile His Pro Glu Asn Lys Thr Val Ile Val 
225                 230                 235                 240 


Arg Cys Ser Gln Pro Leu Val Gly Met Ser Gly Lys Arg Asn Lys Asp 
                245                 250                 255     


Asp Glu Lys Tyr Leu Asp Val Ile Arg Glu Thr Asn Lys Gln Ile Ser 
            260                 265                 270         


Lys Leu Thr Ile Tyr Asp Ala Arg Pro Ser Val Asn Ala Val Ala Asn 
        275                 280                 285             


Lys Ala Thr Gly Gly Gly Tyr Glu Ser Asp Asp Ala Tyr His Asn Ala 
    290                 295                 300                 


Glu Leu Phe Phe Leu Asp Ile His Asn Ile His Val Met Arg Glu Ser 
305                 310                 315                 320 


Leu Lys Lys Val Lys Asp Ile Val Tyr Pro Asn Val Glu Glu Ser His 
                325                 330                 335     


Trp Leu Ser Ser Leu Glu Ser Thr His Trp Leu Glu His Ile Lys Leu 
            340                 345                 350         


Val Leu Thr Gly Ala Ile Gln Val Ala Asp Lys Val Ser Ser Gly Lys 
        355                 360                 365             


Ser Ser Val Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln 
    370                 375                 380                 


Leu Thr Ser Leu Ala Met Leu Met Leu Asp Ser Phe Tyr Arg Ser Ile 
385                 390                 395                 400 


Glu Gly Phe Glu Ile Leu Val Gln Lys Glu Trp Ile Ser Phe Gly His 
                405                 410                 415     


Lys Phe Ala Ser Arg Ile Gly His Gly Asp Lys Asn His Thr Asp Ala 
            420                 425                 430         


Asp Arg Ser Pro Ile Phe Leu Gln Phe Ile Asp Cys Val Trp Gln Met 
        435                 440                 445             


Ser Lys Gln Phe Pro Thr Ala Phe Glu Phe Asn Glu Gln Phe Leu Ile 
    450                 455                 460                 


Ile Ile Leu Asp His Leu Tyr Ser Cys Arg Phe Gly Thr Phe Leu Phe 
465                 470                 475                 480 


Asn Cys Glu Ser Ala Arg Glu Arg Gln Lys Val Thr Glu Arg Thr Val 
                485                 490                 495     


Ser Leu Trp Ser Leu Ile Asn Ser Asn Lys Glu Lys Phe Lys Asn Pro 
            500                 505                 510         


Phe Tyr Thr Lys Glu Ile Asn Arg Val Leu Tyr Pro Val Ala Ser Met 
        515                 520                 525             


Arg His Leu Glu Leu Trp Val Asn Tyr Tyr Ile Arg Trp Asn Pro Arg 
    530                 535                 540                 


Ile Lys Gln Gln Gln Pro Asn Pro Val Glu Gln Arg Tyr Met Glu Leu 
545                 550                 555                 560 


Leu Ala Leu Arg Asp Glu Tyr Ile Lys Arg Leu Glu Glu Leu Gln Leu 
                565                 570                 575     


Ala Asn Ser Ala Lys Leu Ser Asp Pro Pro Thr Ser Pro Ser Ser Pro 
            580                 585                 590         


Ser Gln Met Met Pro His Val Gln Thr His Phe 
        595                 600             


<210> 2
<211> 116
<212> PRT
<213> Mus sp.

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 3
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 4
<211> 111
<212> PRT
<213> Mus sp.

<400> 4
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe His Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210> 5
<211> 3452
<212> DNA
<213> Homo sapiens

<400> 5
agagggggcg gagcagggcc cggcagccga gcagcctggc aacggcggtg gcgcccggag       60

cccgagagtt tccaggatgg cttctgcatc aacttctaaa tataattcac actccttgga      120

gaatgagtct attaagagga cgtctcgaga tggagtcaat cgagatctca ctgaggctgt      180

tcctcgactt ccaggagaaa cactaatcac tgacaaagaa gttatttaca tatgtccttt      240

caatggcccc attaagggaa gagtttacat cacaaattat cgtctttatt taagaagttt      300

ggaaacggat tcttctctaa tacttgatgt tcctctgggt gtgatctcga gaattgaaaa      360

aatgggaggc gcgacaagta gaggagaaaa ttcctatggt ctagatatta cttgtaaaga      420

catgagaaac ctgaggttcg ctttgaaaca ggaaggccac agcagaagag atatgtttga      480

gatcctcacg agatacgcgt ttcccctggc tcacagtctg ccattatttg catttttaaa      540

tgaagaaaag tttaacgtgg atggatggac agtttacaat ccagtggaag aatacaggag      600

gcagggcttg cccaatcacc attggagaat aacttttatt aataagtgct atgagctctg      660

tgacacttac cctgctcttt tggtggttcc gtatcgtgcc tcagatgatg acctccggag      720

agttgcaact tttaggtccc gaaatcgaat tccagtgctg tcatggattc atccagaaaa      780

taagacggtc attgtgcgtt gcagtcagcc tcttgtcggt atgagtggga aacgaaataa      840

agatgatgag aaatatctcg atgttatcag ggagactaat aaacaaattt ctaaactcac      900

catttatgat gcaagaccca gcgtaaatgc agtggccaac aaggcaacag gaggaggata      960

tgaaagtgat gatgcatatc ataacgccga acttttcttc ttagacattc ataatattca     1020

tgttatgcgg gaatctttaa aaaaagtgaa ggacattgtt tatcctaatg tagaagaatc     1080

tcattggttg tccagtttgg agtctactca ttggttagaa catatcaagc tcgttttgac     1140

aggagccatt caagtagcag acaaagtttc ttcagggaag agttcagtgc ttgtgcattg     1200

cagtgacgga tgggacagga ctgctcagct gacatccttg gccatgctga tgttggatag     1260

cttctatagg agcattgaag ggttcgaaat actggtacaa aaagaatgga taagttttgg     1320

acataaattt gcatctcgaa taggtcatgg tgataaaaac cacaccgatg ctgaccgttc     1380

tcctattttt ctccagttta ttgattgtgt gtggcaaatg tcaaaacagt tccctacagc     1440

ttttgaattc aatgaacaat ttttgattat aattttggat catctgtata gttgccgatt     1500

tggtactttc ttattcaact gtgaatctgc tcgagaaaga cagaaggtta cagaaaggac     1560

tgtttcttta tggtcactga taaacagtaa taaagaaaaa ttcaaaaacc ccttctatac     1620

taaagaaatc aatcgagttt tatatccagt tgccagtatg cgtcacttgg aactctgggt     1680

gaattactac attagatgga accccaggat caagcaacaa cagccgaatc cagtggagca     1740

gcgttacatg gagctcttag ccttacgcga cgaatacata aagcggcttg aggaactgca     1800

gctcgccaac tctgccaagc tttctgatcc cccaacttca ccttccagtc cttcgcaaat     1860

gatgccccat gtgcaaactc acttctgagg ggggaccctg gcaccgcatt agagctcgaa     1920

ataaaggcga tagctgactt tcatttgggg catttgtaaa aagtagatta aaatatttgc     1980

ctccatgtag aacttgaact aacataatct taaactcttg aatatgtgcc ttctagaata     2040

catattacaa gaaaactaca gggtccacac ggcaatcaga agaaaggagc tgagatgagg     2100

ttttggaaaa ccctgacacc tttaaaaagc agtttttgaa agacaaaatt tagatttaat     2160

ttacgtcttg agaaatacta tatatacaat atatattttg tgggcttaat tgaaacaaca     2220

ttattttaaa atcaaagggg atatatgttt gtggaatgga ttttcctgaa gctgcttaac     2280

agttgctttg gattctctaa gatgaatcca aatgtgaaag atgcatgtta ctgccaaaac     2340

caaattgagc tcagcttcct aggcattacc caaaagcaag gtgtttaagt aattgccagc     2400

ttttatacca tcatgagtgg tgacttaagg agaaatagct gtatagatga gtttttcatt     2460

atttggaaat ttaggggtag aaaatgtttt cccctaattt tccagagaag cctattttta     2520

tatttttaaa aaactgacag ggcccagtta aatatgattt gcatttttta aatttgccag     2580

ttttattttc taaattcttt catgagcttg cctaaaattc ggaatggttt tcgggttgtg     2640

gcaaacccca aagagagcac tgtccaagga tgtcgggagc atcctgctgc ttaggggaat     2700

gttttcgcaa atgttgctct agtcagtcca gctcatctgc caaaatgtag ggctaccgtc     2760

ttggatgcat gagctattgc tagagcatca tccttagaaa tcagtgcccc agatgtacat     2820

gtgttgagcg tattcttgaa agtattgtgt ttatgcattt caatttcaat ggtgttggct     2880

tcccctcccc accccacgcg tgcataaaaa ctggttctac aaatttttac ttgaagtacc     2940

aggccgtttg ctttttcagg ttgttttgtt ttatagtatt aagtgaaatt ttaaatgcac     3000

agttctattt gctatctgaa ctaattcatt tattaagtat atttgtaaaa gctaaggctc     3060

gagttaaaac aatgaagtgt tttacaatga tttgtaaagg actatttata actaatatgg     3120

ttttgttttc aatgaattaa gaaagattaa atatatcttt gtaaattatt ttatgtcata     3180

gtttaattgg tctaccaagt aagacatctc aaatacagta gtataatgta tgaattttgt     3240

aagtataaga aattttatta gacattctct tactttttgt aaatgctgta aatatttcat     3300

aaattaacaa agtgtcactc cataaaaaga aagctaatac taatagccta aaagattttg     3360

tgaaatttca tgaaaacttt ttaatggcaa taatgactaa agacctgctg taataaatgt     3420

attaactgaa acctaaaaaa aaaaaaaaaa aa                                   3452


<210> 6
<211> 603
<212> PRT
<213> Mus musculus

<400> 6
Met Ala Ser Ala Ser Ala Ser Lys Tyr Asn Ser His Ser Leu Glu Asn 
1               5                   10                  15      


Glu Ser Ile Lys Lys Val Ser Gln Asp Gly Val Ser Gln Asp Val Ser 
            20                  25                  30          


Glu Thr Val Pro Arg Leu Pro Gly Glu Leu Leu Ile Thr Glu Lys Glu 
        35                  40                  45              


Val Ile Tyr Ile Cys Pro Phe Asn Gly Pro Ile Lys Gly Arg Val Tyr 
    50                  55                  60                  


Ile Thr Asn Tyr Arg Leu Tyr Leu Arg Ser Leu Glu Thr Asp Ser Ala 
65                  70                  75                  80  


Leu Ile Leu Asp Val Pro Leu Gly Val Ile Ser Arg Ile Glu Tyr Met 
                85                  90                  95      


Gly Gly Ala Thr Ser Arg Gly Glu Asn Ser Tyr Gly Leu Asp Ile Thr 
            100                 105                 110         


Cys Lys Asp Leu Arg Asn Leu Arg Phe Ala Leu Lys Gln Glu Gly His 
        115                 120                 125             


Ser Arg Arg Asp Met Phe Glu Ile Leu Val Lys His Ala Phe Pro Leu 
    130                 135                 140                 


Ala His Asn Leu Pro Leu Phe Ala Phe Val Asn Glu Glu Lys Phe Asn 
145                 150                 155                 160 


Val Asp Gly Trp Thr Val Tyr Asn Pro Val Glu Glu Tyr Arg Arg Gln 
                165                 170                 175     


Gly Leu Pro Asn His His Trp Arg Ile Ser Phe Ile Asn Lys Cys Tyr 
            180                 185                 190         


Glu Leu Cys Glu Thr Tyr Pro Ala Leu Leu Val Val Pro Tyr Arg Thr 
        195                 200                 205             


Ser Asp Asp Asp Leu Arg Arg Ile Ala Thr Phe Arg Ser Arg Asn Arg 
    210                 215                 220                 


Leu Pro Val Leu Ser Trp Ile His Pro Glu Asn Lys Met Val Ile Met 
225                 230                 235                 240 


Arg Cys Ser Gln Pro Leu Val Gly Met Ser Gly Lys Arg Asn Lys Asp 
                245                 250                 255     


Asp Glu Lys Tyr Leu Asp Val Ile Arg Glu Thr Asn Lys Gln Thr Ser 
            260                 265                 270         


Lys Leu Met Ile Tyr Asp Ala Arg Pro Ser Val Asn Ala Val Ala Asn 
        275                 280                 285             


Lys Ala Thr Gly Gly Gly Tyr Glu Ser Asp Asp Ala Tyr Gln Asn Ser 
    290                 295                 300                 


Glu Leu Ser Phe Leu Asp Ile His Asn Ile His Val Met Arg Glu Ser 
305                 310                 315                 320 


Leu Lys Lys Val Lys Asp Ile Val Tyr Pro Asn Ile Glu Glu Ser His 
                325                 330                 335     


Trp Leu Ser Ser Leu Glu Ser Thr His Trp Leu Glu His Ile Lys Leu 
            340                 345                 350         


Val Leu Thr Gly Ala Ile Gln Val Ala Asp Gln Val Ser Ser Gly Lys 
        355                 360                 365             


Ser Ser Val Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln 
    370                 375                 380                 


Leu Thr Ser Leu Ala Met Leu Met Leu Asp Ser Phe Tyr Arg Thr Ile 
385                 390                 395                 400 


Glu Gly Phe Glu Ile Leu Val Gln Lys Glu Trp Ile Ser Phe Gly His 
                405                 410                 415     


Lys Phe Ala Ser Arg Ile Gly His Gly Asp Lys Asn His Ala Asp Ala 
            420                 425                 430         


Asp Arg Ser Pro Ile Phe Leu Gln Phe Ile Asp Cys Val Trp Gln Met 
        435                 440                 445             


Ser Lys Gln Phe Pro Thr Ala Phe Glu Phe Asn Glu Gly Phe Leu Ile 
    450                 455                 460                 


Thr Val Leu Asp His Leu Tyr Ser Cys Arg Phe Gly Thr Phe Leu Phe 
465                 470                 475                 480 


Asn Cys Asp Ser Ala Arg Glu Arg Gln Lys Leu Thr Glu Arg Thr Val 
                485                 490                 495     


Ser Leu Trp Ser Leu Ile Asn Ser Asn Lys Asp Lys Phe Lys Asn Pro 
            500                 505                 510         


Phe Tyr Thr Lys Glu Ile Asn Arg Val Leu Tyr Pro Val Ala Ser Met 
        515                 520                 525             


Arg His Leu Glu Leu Trp Val Asn Tyr Tyr Ile Arg Trp Asn Pro Arg 
    530                 535                 540                 


Val Lys Gln Gln Gln Pro Asn Pro Val Glu Gln Arg Tyr Met Glu Leu 
545                 550                 555                 560 


Leu Ala Leu Arg Asp Asp Tyr Ile Lys Arg Leu Glu Glu Leu Gln Leu 
                565                 570                 575     


Ala Asn Ser Ala Lys Leu Ala Asp Ala Pro Ala Ser Thr Ser Ser Ser 
            580                 585                 590         


Ser Gln Met Val Pro His Val Gln Thr His Phe 
        595                 600             


<210> 7
<211> 3338
<212> DNA
<213> Mus musculus

<400> 7
ggtgagttcg ctttcttggc tgacctggct cggagccggg cattgcgggg atccaggatt       60

ggaaaggttc caggatggct tctgcatcag catctaagta taattcacac tccttggaga      120

atgaatccat taagaaagtg tctcaagatg gagtcagtca ggatgtgagt gagactgtcc      180

ctcggctccc aggggagtta ctaattactg aaaaagaagt tatttacata tgtcctttca      240

atggccccat taagggaaga gtttacatca caaattatcg tctttattta agaagtttgg      300

aaacggattc tgctctaata cttgatgttc ctctgggtgt gatatcaaga attgaatata      360

tgggaggcgc gactagtaga ggagaaaatt cctatggtct agatattact tgtaaagatt      420

tgagaaacct gaggtttgca ttgaagcaag aaggccacag cagaagagat atgtttgaga      480

tccttgtaaa acatgccttt cctctggcac acaatctgcc attatttgca tttgtaaatg      540

aagagaagtt taacgtggat gggtggactg tttataatcc agttgaagaa tatagaaggc      600

agggcctgcc caatcaccat tggaggataa gttttattaa caagtgctat gagctctgtg      660

agacataccc tgctcttttg gtggttccct atcggacctc agatgatgat cttaggagga      720

tcgcaacgtt tagatcccga aatcggcttc ctgtactgtc gtggattcac ccagaaaaca      780

aaatggtcat tatgcgctgc agtcagcctc ttgtcggtat gagtggtaaa agaaataaag      840

atgacgagaa atacctggat gtgatcaggg aaactaacaa acaaacttct aagctcatga      900

tttatgatgc acgacccagt gtaaatgcag tcgccaacaa ggcaacagga ggaggatatg      960

aaagtgatga cgcatatcaa aactcagaac tttccttctt agacattcat aatattcatg     1020

ttatgcgaga atctttaaaa aaagtgaaag atattgttta tcccaacata gaagaatctc     1080

attggttgtc cagtttggag tctactcatt ggttagaaca tatcaagctt gttctgaccg     1140

gtgccattca agtggcagac caagtgtctt caggaaagag ctcggtactt gtgcactgca     1200

gtgacggatg ggacaggacc gctcagctga catccttggc catgctgatg ttggacagct     1260

tctacagaac tattgaaggc tttgagatat tggtacagaa agagtggata agttttggcc     1320

ataaatttgc atctagaata ggtcatggtg ataaaaacca tgctgatgct gatcgatctc     1380

ctatttttct tcagtttatt gactgtgtgt ggcagatgtc gaaacagttc cccacagctt     1440

ttgagttcaa tgaaggcttt ttgattaccg ttttggatca tctgtatagc tgtcgatttg     1500

gtactttctt attcaactgt gactcggctc gagaaagaca gaaacttaca gaaagaacag     1560

tttctctatg gtcgctaatt aacagcaata aagacaaatt caaaaacccc ttctatacaa     1620

aagaaatcaa tcgggttttg tatccagttg ccagcatgcg tcacttggaa ctgtgggtga     1680

attattacat ccgatggaat cccagggtca agcagcaaca gcccaaccca gtggagcagc     1740

gttacatgga gcttttggcc ttgcgtgacg attatataaa gaggctcgag gaattgcagc     1800

tggccaactc cgccaagctt gctgatgccc ccgcttcgac ttccagttcg tcacagatgg     1860

tgccccatgt gcagacgcac ttctgagggg actcacttct ggcactgcac ttgaactcta     1920

gataagtgaa atagctgact ctcattctgg gcatgtggac aaagtagatt taaagtgtct     1980

gcctccattt agaagttcaa ctaacatctt agacttttga gtatgtgcct tctgtaatac     2040

atatcacaag aaatcgatgg tgtccgtgtg gcaatcataa ggaaggagtc aagagggggt     2100

tctggaaaat cctcatactt ttttttacaa agcacttttg caaagataaa acttaaattt     2160

aatttacctc tatataaatt ctacatatac agtatgtatt ttgtgggctt aattgaaata     2220

ttattttaaa tccagggggg agatttgttt gcaaaatgta ttttcctcca gctgcttata     2280

acagttgctt tggattatct aaaattaatc caaatgtgaa agatgggtat tactgccaaa     2340

gccaaattgc actctgcttc ttcagcaaat tccaagagca aggcgtttaa ataattgcca     2400

atttttattt taccataagt ggtaaggtaa aaagaaagat gaacatttca tcattttgaa     2460

tttttgaaaa taaaaggttc tcccatcatt tttcaagaga agcacatttt tatattaaga     2520

aaaagtgata aggtttgatt tttttttccc tcaacattct cagctttgct ttctaaatta     2580

tcccatgatt tttgtctaac actgagtcat actcaggttg aaggaaaccc ataaatagca     2640

ctgtgcgagg agctggctgg cttctgctgc ttagaggaat atgttcgcaa acatgcctct     2700

agtcaattcg ccttatctgc tgaagtgtag gggcaccgcc ttgaatggat gagctatggc     2760

tagagcatct ttctttacag taatgcccca ggtgtattct gtttatgtct ctctgtttaa     2820

atggtgtgcg tgcataaaaa cttgctctgc acattattac ttgaagtact gggcaatttg     2880

ctttttcagg ttttttttca ttttgttttg tagtatgaaa tggaatttta aatgcacagt     2940

tctatttgat atccgaacta attcatttag taaatatatt tgtaaaagct aaagttaaat     3000

caattaatgt tttacagtga tttgtaaagg attatttata gctaatatgg ttttgttttc     3060

agtgaattaa gagagattac atttatcttt gtaaattatt ttatgtcata gcttaatggc     3120

ctaccaaatg agacatctca aatataatag tataatgtat ggattttgta agtataaaaa     3180

ttattagata ttcgtttgct ttttgtaaac actgtaaata tttcataaat taaaatgtgt     3240

cactccataa gaagaaaaaa ctaatactaa tagttgacag gaattggtga aatttcatga     3300

aaatattttc attgcaataa atattaaaag acctgctg                             3338


<210> 8
<211> 553
<212> PRT
<213> Rattus norvegicus

<400> 8
Met Ala Ser Ser Ser Ala Ser Asp Cys Asp Ala His Pro Val Glu Arg 
1               5                   10                  15      


Glu Ser Met Arg Lys Val Ser Gln Asp Gly Val Arg Gln Asp Met Ser 
            20                  25                  30          


Lys Ser Gly Pro Arg Leu Pro Gly Glu Ser Ala Ile Thr Asp Lys Glu 
        35                  40                  45              


Val Ile Tyr Ile Cys Pro Phe Ser Gly Pro Val Lys Gly Arg Leu Tyr 
    50                  55                  60                  


Ile Thr Asn Tyr Arg Leu Tyr Leu Arg Ser Leu Glu Thr Asp Leu Ala 
65                  70                  75                  80  


Pro Ile Leu Asp Val Pro Leu Gly Val Ile Ser Arg Ile Glu Lys Met 
                85                  90                  95      


Gly Gly Val Thr Ser Arg Gly Glu Asn Ser Tyr Gly Leu Asp Ile Thr 
            100                 105                 110         


Cys Lys Asp Leu Arg Asn Leu Arg Phe Ala Leu Lys Gln Glu Gly His 
        115                 120                 125             


Ser Arg Arg Asp Ile Phe Asp Val Leu Thr Arg His Ala Phe Pro Leu 
    130                 135                 140                 


Ala Tyr Asn Leu Pro Leu Phe Ala Phe Val Asn Glu Glu Lys Phe Lys 
145                 150                 155                 160 


Val Asp Gly Trp Ala Ile Tyr Asn Pro Val Glu Glu Tyr Arg Arg Gln 
                165                 170                 175     


Gly Leu Pro Asp Arg His Trp Arg Ile Ser Phe Val Asn Gln Arg Tyr 
            180                 185                 190         


Glu Leu Cys Asp Thr Tyr Pro Ala Leu Leu Val Val Pro Tyr Arg Ala 
        195                 200                 205             


Ser Asp Asp Asp Leu Arg Arg Val Ala Thr Phe Arg Ser Arg Asn Arg 
    210                 215                 220                 


Ile Pro Val Leu Ser Trp Ile His Pro Glu Asn Arg Ala Ala Ile Met 
225                 230                 235                 240 


Arg Cys Ser Gln Pro Leu Val Gly Val Gly Gly Lys Arg Ser Arg Asp 
                245                 250                 255     


Asp Glu Arg Tyr Leu Asp Ile Ile Arg Glu Thr Asn Lys Gln Thr Ser 
            260                 265                 270         


Lys Leu Thr Ile Tyr Asp Ala Arg Pro Gly Val Asn Ala Val Ala Asn 
        275                 280                 285             


Lys Ala Thr Gly Gly Gly Tyr Glu Gly Glu Asp Ala Tyr Pro His Ala 
    290                 295                 300                 


Glu Leu Ser Phe Leu Asp Ile His Asn Ile His Val Met Arg Glu Ser 
305                 310                 315                 320 


Leu Arg Arg Val Arg Asp Ile Val Tyr Pro His Val Glu Glu Ala His 
                325                 330                 335     


Trp Leu Ser Ser Leu Glu Ser Thr His Trp Leu Glu His Ile Lys Leu 
            340                 345                 350         


Leu Leu Thr Gly Ala Ile Arg Val Ala Asp Lys Val Ala Ser Gly Leu 
        355                 360                 365             


Ser Ser Val Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln 
    370                 375                 380                 


Leu Thr Thr Leu Ala Met Leu Met Leu Asp Gly Phe Tyr Arg Ser Ile 
385                 390                 395                 400 


Glu Gly Phe Glu Ile Leu Val Gln Lys Glu Trp Ile Ser Phe Gly His 
                405                 410                 415     


Lys Phe Ser Ser Arg Ile Gly His Gly Asp Lys Asn His Ala Asp Ala 
            420                 425                 430         


Asp Arg Ser Pro Ile Phe Leu Gln Phe Ile Asp Cys Val Trp Gln Met 
        435                 440                 445             


Thr Lys Gln Phe Pro Thr Ala Phe Glu Phe Asn Glu Cys Phe Leu Val 
    450                 455                 460                 


Ala Ile Leu Asp His Leu Tyr Ser Cys Arg Phe Gly Thr Phe Leu Leu 
465                 470                 475                 480 


Asn Cys Glu Ala Ala Arg Glu Arg Gln Arg Leu Ala Glu Arg Thr Val 
                485                 490                 495     


Ser Val Trp Ser Leu Ile Asn Ser Asn Lys Asp Glu Phe Thr Asn Pro 
            500                 505                 510         


Phe Tyr Ala Arg Glu Ser Asn Arg Val Ile Tyr Pro Val Thr Ser Val 
        515                 520                 525             


Arg His Leu Glu Leu Trp Val Asn Tyr Tyr Ile Arg Trp Asn Pro Arg 
    530                 535                 540                 


Ile Arg Gln Gln Gln Pro His Pro Met 
545                 550             


<210> 9
<211> 2536
<212> DNA
<213> Rattus norvegicus

<400> 9
gcgagcgcgt tggcaccagc ggcccccgga gtctcaggtt ccaggatggc gtcctcgtca       60

gcctctgact gtgatgcaca ccccgtggag cgtgagtcca tgaggaaggt gtctcaagat      120

ggagtccgtc aggatatgag caagagtggg cctcgcctcc caggggaatc agccatcact      180

gacaaggaag tcatctacat ttgtcccttc agcggccccg taaagggacg actttacatc      240

accaattacc gtctctacct gagaagtctg gagacggact tggctccgat tcttgacgtc      300

cccctaggcg tgatatcgag aatagagaaa atgggaggcg tgacgagtcg aggagagaat      360

tcctacggcc ttgatatcac ctgcaaagac ctgaggaacc tgaggttcgc tctgaagcag      420

gaaggacaca gcaggaggga catctttgac gtcctcacca gacacgcctt ccccctggct      480

tacaacctgc cgttgtttgc attcgtgaac gaggagaagt ttaaagtgga tggatgggcg      540

atttacaacc cggttgaaga gtacagaagg cagggcctcc ccgatcgcca ttggcggata      600

agtttcgtca atcagcgcta cgagctctgt gacacctacc ctgccctcct ggtcgtcccc      660

taccgtgcgt ccgatgatga cctcagaaga gttgcaacct ttaggtccag aaaccggatt      720

cccgtgctgt cgtggatcca cccagagaac agggcggcga tcatgcggtg cagtcagcct      780

ctggttggtg tgggcgggaa gagaagcaga gatgatgaga gatacctgga catcatccgg      840

gaaaccaata agcagacctc gaagctcaca atttacgatg cgcggcccgg cgtcaatgcg      900

gtggccaaca aggcaacggg aggcggctat gagggcgagg acgcgtaccc tcacgcggag      960

ctctccttcc tggacatcca caacatccac gtgatgcggg aatccttacg gagggtgagg     1020

gacatcgtgt acccccacgt ggaggaagct cattggctgt ccagcttgga gtccacccat     1080

tggttagagc acatcaagct tctcctcact ggtgccatcc gggtcgcaga caaggtggca     1140

tcggggctga gttcagtcct cgtgcactgc agtgacggct gggaccggac ggctcaactg     1200

accacgctgg ccatgctgat gctcgatggc ttctaccgca gcatcgaggg ctttgagatc     1260

ctggtgcaga aggagtggat cagcttcgga cacaagtttt catctagaat tggccacggt     1320

gacaagaacc acgcggatgc cgaccgctcc ccgattttcc tgcagttcat cgactgcgtg     1380

tggcagatga cgaagcagtt ccccacagct ttcgagttca acgagtgctt cctggttgcc     1440

atcttggatc acctgtacag ctgccggttc gggactttct tactaaactg tgaggcggca     1500

cgggagagac agagactcgc agaaaggacg gtgtctgtgt ggtccctgat caacagcaac     1560

aaagacgaat tcacaaaccc gttctacgca agggagagca accgcgtgat ctacccggtc     1620

accagcgtgc gccacctgga actgtgggtg aattactaca tccggtggaa ccccaggatc     1680

cggcagcagc agccccaccc catgtagcag cgatataatg agctcctggc cctgcgtgac     1740

gattacatca agaagctgga ggagctgcag ctggccacgc ccaccaagct cactgactcc     1800

tccaccccgc cttccggttc cgcacagata gctccccgca tgcaaactca cttctgaggg     1860

ggttccgggc cccaaaccct gaataagtga cgtcaccaac ttccgttctg tgcgcttgtg     1920

caaaggggat ataaagtctc cgcctctgtg tagaagtcga actaacaccc tagaaccttg     1980

tgtgacacgt gtgagtgtgc gccttttgtg acgtgtgagt gtgcgatttg tgtgacatgt     2040

gtgaatgtgt accctgtgtg atacgtgcaa gtgtgcgcct tgtgtaaagt tcgtgagtgt     2100

gcacctcctg taacatgttt tgcaaggaat ctactgcgct tgtgtgccag tcgtgagtac     2160

agagtagggg gggtcccgga aaaatcctca cactttttta caaagcgctt gtgcaaagat     2220

taaaattaaa ttatatcaat aattatataa attattataa ttatattgca aagattaaaa     2280

agttaaattt agtttacctc tatataaatc cagacataca taatatgtac tctgtgcgct     2340

taattgaaac gttattttaa atccagaggg gagatttttt ttgtaaaatg gatttttcct     2400

ccagccactt attttgcaaa gataaaaaag ttaaaataaa agttaaattt aattataaaa     2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2520

aaaaaaaaaa aaaaaa                                                     2536


<210> 10
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210> 11
<211> 873
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe His Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile 
                165                 170                 175     


Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met 
        195                 200                 205             


Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg 
    210                 215                 220                 


Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser Glu Gln Lys Leu Ser Glu Glu Asp Leu Gly Ser Thr Ser Gly Ser 
                245                 250                 255     


Gly Lys Ser Ser Glu Gly Lys Gly Met Ala Ser Ala Ser Thr Ser Lys 
            260                 265                 270         


Tyr Asn Ser His Ser Leu Glu Asn Glu Ser Ile Lys Arg Thr Ser Arg 
        275                 280                 285             


Asp Gly Val Asn Arg Asp Leu Thr Glu Ala Val Pro Arg Leu Pro Gly 
    290                 295                 300                 


Glu Thr Leu Ile Thr Asp Lys Glu Val Ile Tyr Ile Cys Pro Phe Asn 
305                 310                 315                 320 


Gly Pro Ile Lys Gly Arg Val Tyr Ile Thr Asn Tyr Arg Leu Tyr Leu 
                325                 330                 335     


Arg Ser Leu Glu Thr Asp Ser Ser Leu Ile Leu Asp Val Pro Leu Gly 
            340                 345                 350         


Val Ile Ser Arg Ile Glu Lys Met Gly Gly Ala Thr Ser Arg Gly Glu 
        355                 360                 365             


Asn Ser Tyr Gly Leu Asp Ile Thr Cys Lys Asp Met Arg Asn Leu Arg 
    370                 375                 380                 


Phe Ala Leu Lys Gln Glu Gly His Ser Arg Arg Asp Met Phe Glu Ile 
385                 390                 395                 400 


Leu Thr Arg Tyr Ala Phe Pro Leu Ala His Ser Leu Pro Leu Phe Ala 
                405                 410                 415     


Phe Leu Asn Glu Glu Lys Phe Asn Val Asp Gly Trp Thr Val Tyr Asn 
            420                 425                 430         


Pro Val Glu Glu Tyr Arg Arg Gln Gly Leu Pro Asn His His Trp Arg 
        435                 440                 445             


Ile Thr Phe Ile Asn Lys Cys Tyr Glu Leu Cys Asp Thr Tyr Pro Ala 
    450                 455                 460                 


Leu Leu Val Val Pro Tyr Arg Ala Ser Asp Asp Asp Leu Arg Arg Val 
465                 470                 475                 480 


Ala Thr Phe Arg Ser Arg Asn Arg Ile Pro Val Leu Ser Trp Ile His 
                485                 490                 495     


Pro Glu Asn Lys Thr Val Ile Val Arg Cys Ser Gln Pro Leu Val Gly 
            500                 505                 510         


Met Ser Gly Lys Arg Asn Lys Asp Asp Glu Lys Tyr Leu Asp Val Ile 
        515                 520                 525             


Arg Glu Thr Asn Lys Gln Ile Ser Lys Leu Thr Ile Tyr Asp Ala Arg 
    530                 535                 540                 


Pro Ser Val Asn Ala Val Ala Asn Lys Ala Thr Gly Gly Gly Tyr Glu 
545                 550                 555                 560 


Ser Asp Asp Ala Tyr His Asn Ala Glu Leu Phe Phe Leu Asp Ile His 
                565                 570                 575     


Asn Ile His Val Met Arg Glu Ser Leu Lys Lys Val Lys Asp Ile Val 
            580                 585                 590         


Tyr Pro Asn Val Glu Glu Ser His Trp Leu Ser Ser Leu Glu Ser Thr 
        595                 600                 605             


His Trp Leu Glu His Ile Lys Leu Val Leu Thr Gly Ala Ile Gln Val 
    610                 615                 620                 


Ala Asp Lys Val Ser Ser Gly Lys Ser Ser Val Leu Val His Cys Ser 
625                 630                 635                 640 


Asp Gly Trp Asp Arg Thr Ala Gln Leu Thr Ser Leu Ala Met Leu Met 
                645                 650                 655     


Leu Asp Ser Phe Tyr Arg Ser Ile Glu Gly Phe Glu Ile Leu Val Gln 
            660                 665                 670         


Lys Glu Trp Ile Ser Phe Gly His Lys Phe Ala Ser Arg Ile Gly His 
        675                 680                 685             


Gly Asp Lys Asn His Thr Asp Ala Asp Arg Ser Pro Ile Phe Leu Gln 
    690                 695                 700                 


Phe Ile Asp Cys Val Trp Gln Met Ser Lys Gln Phe Pro Thr Ala Phe 
705                 710                 715                 720 


Glu Phe Asn Glu Gln Phe Leu Ile Ile Ile Leu Asp His Leu Tyr Ser 
                725                 730                 735     


Cys Arg Phe Gly Thr Phe Leu Phe Asn Cys Glu Ser Ala Arg Glu Arg 
            740                 745                 750         


Gln Lys Val Thr Glu Arg Thr Val Ser Leu Trp Ser Leu Ile Asn Ser 
        755                 760                 765             


Asn Lys Glu Lys Phe Lys Asn Pro Phe Tyr Thr Lys Glu Ile Asn Arg 
    770                 775                 780                 


Val Leu Tyr Pro Val Ala Ser Met Arg His Leu Glu Leu Trp Val Asn 
785                 790                 795                 800 


Tyr Tyr Ile Arg Trp Asn Pro Arg Ile Lys Gln Gln Gln Pro Asn Pro 
                805                 810                 815     


Val Glu Gln Arg Tyr Met Glu Leu Leu Ala Leu Arg Asp Glu Tyr Ile 
            820                 825                 830         


Lys Arg Leu Glu Glu Leu Gln Leu Ala Asn Ser Ala Lys Leu Ser Asp 
        835                 840                 845             


Pro Pro Thr Ser Pro Ser Ser Pro Ser Gln Met Met Pro His Val Gln 
    850                 855                 860                 


Thr His Phe His His His His His His 
865                 870             


<210> 12
<211> 5
<212> PRT
<213> Mus sp.

<400> 12
Asn Tyr Gly Met His 
1               5   


<210> 13
<211> 17
<212> PRT
<213> Mus sp.

<400> 13
Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210> 14
<211> 7
<212> PRT
<213> Mus sp.

<400> 14
Arg Gly Leu Leu Leu Asp Tyr 
1               5           


<210> 15
<211> 15
<212> PRT
<213> Mus sp.

<400> 15
Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210> 16
<211> 7
<212> PRT
<213> Mus sp.

<400> 16
Tyr Ala Ser Tyr Leu Glu Ser 
1               5           


<210> 17
<211> 9
<212> PRT
<213> Mus sp.

<400> 17
Gln His Ser Arg Glu Phe Pro Trp Thr 
1               5                   


<210> 18
<211> 878
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Ser Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
1               5                   10                  15      


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
            20                  25                  30          


Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys 
        35                  40                  45              


Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu 
    50                  55                  60                  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
65                  70                  75                  80  


His Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Gln His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 
    130                 135                 140                 


Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp 
            180                 185                 190         


Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
        195                 200                 205             


Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Leu Thr Val Ser Ser Glu Gln Lys Leu Ser Glu Glu Asp Leu Gly 
                245                 250                 255     


Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly Met Ala Ser 
            260                 265                 270         


Ala Ser Thr Ser Lys Tyr Asn Ser His Ser Leu Glu Asn Glu Ser Ile 
        275                 280                 285             


Lys Arg Thr Ser Arg Asp Gly Val Asn Arg Asp Leu Thr Glu Ala Val 
    290                 295                 300                 


Pro Arg Leu Pro Gly Glu Thr Leu Ile Thr Asp Lys Glu Val Ile Tyr 
305                 310                 315                 320 


Ile Cys Pro Phe Asn Gly Pro Ile Lys Gly Arg Val Tyr Ile Thr Asn 
                325                 330                 335     


Tyr Arg Leu Tyr Leu Arg Ser Leu Glu Thr Asp Ser Ser Leu Ile Leu 
            340                 345                 350         


Asp Val Pro Leu Gly Val Ile Ser Arg Ile Glu Lys Met Gly Gly Ala 
        355                 360                 365             


Thr Ser Arg Gly Glu Asn Ser Tyr Gly Leu Asp Ile Thr Cys Lys Asp 
    370                 375                 380                 


Met Arg Asn Leu Arg Phe Ala Leu Lys Gln Glu Gly His Ser Arg Arg 
385                 390                 395                 400 


Asp Met Phe Glu Ile Leu Thr Arg Tyr Ala Phe Pro Leu Ala His Ser 
                405                 410                 415     


Leu Pro Leu Phe Ala Phe Leu Asn Glu Glu Lys Phe Asn Val Asp Gly 
            420                 425                 430         


Trp Thr Val Tyr Asn Pro Val Glu Glu Tyr Arg Arg Gln Gly Leu Pro 
        435                 440                 445             


Asn His His Trp Arg Ile Thr Phe Ile Asn Lys Cys Tyr Glu Leu Cys 
    450                 455                 460                 


Asp Thr Tyr Pro Ala Leu Leu Val Val Pro Tyr Arg Ala Ser Asp Asp 
465                 470                 475                 480 


Asp Leu Arg Arg Val Ala Thr Phe Arg Ser Arg Asn Arg Ile Pro Val 
                485                 490                 495     


Leu Ser Trp Ile His Pro Glu Asn Lys Thr Val Ile Val Arg Cys Ser 
            500                 505                 510         


Gln Pro Leu Val Gly Met Ser Gly Lys Arg Asn Lys Asp Asp Glu Lys 
        515                 520                 525             


Tyr Leu Asp Val Ile Arg Glu Thr Asn Lys Gln Ile Ser Lys Leu Thr 
    530                 535                 540                 


Ile Tyr Asp Ala Arg Pro Ser Val Asn Ala Val Ala Asn Lys Ala Thr 
545                 550                 555                 560 


Gly Gly Gly Tyr Glu Ser Asp Asp Ala Tyr His Asn Ala Glu Leu Phe 
                565                 570                 575     


Phe Leu Asp Ile His Asn Ile His Val Met Arg Glu Ser Leu Lys Lys 
            580                 585                 590         


Val Lys Asp Ile Val Tyr Pro Asn Val Glu Glu Ser His Trp Leu Ser 
        595                 600                 605             


Ser Leu Glu Ser Thr His Trp Leu Glu His Ile Lys Leu Val Leu Thr 
    610                 615                 620                 


Gly Ala Ile Gln Val Ala Asp Lys Val Ser Ser Gly Lys Ser Ser Val 
625                 630                 635                 640 


Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln Leu Thr Ser 
                645                 650                 655     


Leu Ala Met Leu Met Leu Asp Ser Phe Tyr Arg Ser Ile Glu Gly Phe 
            660                 665                 670         


Glu Ile Leu Val Gln Lys Glu Trp Ile Ser Phe Gly His Lys Phe Ala 
        675                 680                 685             


Ser Arg Ile Gly His Gly Asp Lys Asn His Thr Asp Ala Asp Arg Ser 
    690                 695                 700                 


Pro Ile Phe Leu Gln Phe Ile Asp Cys Val Trp Gln Met Ser Lys Gln 
705                 710                 715                 720 


Phe Pro Thr Ala Phe Glu Phe Asn Glu Gln Phe Leu Ile Ile Ile Leu 
                725                 730                 735     


Asp His Leu Tyr Ser Cys Arg Phe Gly Thr Phe Leu Phe Asn Cys Glu 
            740                 745                 750         


Ser Ala Arg Glu Arg Gln Lys Val Thr Glu Arg Thr Val Ser Leu Trp 
        755                 760                 765             


Ser Leu Ile Asn Ser Asn Lys Glu Lys Phe Lys Asn Pro Phe Tyr Thr 
    770                 775                 780                 


Lys Glu Ile Asn Arg Val Leu Tyr Pro Val Ala Ser Met Arg His Leu 
785                 790                 795                 800 


Glu Leu Trp Val Asn Tyr Tyr Ile Arg Trp Asn Pro Arg Ile Lys Gln 
                805                 810                 815     


Gln Gln Pro Asn Pro Val Glu Gln Arg Tyr Met Glu Leu Leu Ala Leu 
            820                 825                 830         


Arg Asp Glu Tyr Ile Lys Arg Leu Glu Glu Leu Gln Leu Ala Asn Ser 
        835                 840                 845             


Ala Lys Leu Ser Asp Pro Pro Thr Ser Pro Ser Ser Pro Ser Gln Met 
    850                 855                 860                 


Met Pro His Val Gln Thr His Phe His His His His His His 
865                 870                 875             


<210> 19
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Ala Gly Ile His 
1               


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Ala Gly Ile His 
1               5   


<210> 21
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide	


<220>
<221> misc_feature
<222> (1)..(50)
<223> This sequence may encompass 1 to 10 "GGGGS" repeats

<400> 21
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210> 22
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 22
His His His His His His 
1               5       


