                         SEQUENCE LISTING

<110>  Penn State Research Foundation
       Penn State Research Foundation; Virginia Commonwealth 
       University
 
<120>  COMPOSITIONS AND METHODS RELATING TO DENND1A VARIANT 2 AND 
       POLYCYSTIC OVARY SYNDROME

<130>  074339.00003

<150>  61/649,568
<151>  2012-05-21

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  2166
<212>  DNA
<213>  Human

<400>  1
cgcgcgccgg gcacgcgcgc cggcgaccat ggcgttcgcc gggctggagc gagtacatta       60

acccctggag gcggcggcgg cggcgaggga gcgagcctcg agcgggcggg ccccagcctg      120

agggaaggga ggaaggggcg gggagagcgc cagagggagg ccggtcggcc gcgggcgggc      180

gggcagcgca gcgccgagcg gggcccgcgg gcccatgagg aggcctgggg accatgggct      240

ccaggatcaa gcagaatcca gagaccacat ttgaagtata tgttgaagtg gcctatccca      300

ggacaggtgg cactctttca gatcctgagg tgcagaggca attcccggag gactacagtg      360

accaggaagt tctacagact ttgaccaagt tttgtttccc cttctatgtg gacagcctca      420

cagttagcca agttggccag aacttcacat tcgtgctcac tgacattgac agcaaacaga      480

gattcgggtt ctgccgctta tcttcaggag cgaagagctg cttctgtatc ttaagctatc      540

tcccctggtt cgaggtattt tataagctgc ttaacatcct ggcagattac acgacaaaaa      600

gacaggaaaa tcagtggaat gagcttcttg aaactctgca caaacttccc atccctgacc      660

caggagtgtc tgtccatctc agcgtgcatt cttattttac tgtgcctgat accagagaac      720

ttcccagcat acctgagaat agaaatctga cagaatattt tgtggctgtg gatgttaaca      780

acatgttgca tctgtacgcc agtatgctgt acgaacgccg gatactcatc atttgcagca      840

aactcagcac tctgactgcc tgcatccacg ggtctgcggc gatgctctac cccatgtact      900

ggcagcacgt gtacatcccc gtgctgccgc cgcatctgct ggactactgc tgtgctccca      960

tgccctacct cataggaatc catttaagtt taatggagaa agtcagaaac atggccctgg     1020

atgatgtcgt gatcctgaat gtggacacca acaccctgga aacccccttc gatgacctcc     1080

agagcctccc aaacgacgtg atctcttccc tgaagaacag gctgaaaaag gtctccacaa     1140

ccactgggga tggtgtggcc agagcgttcc tcaaggccca ggctgctttc ttcggtagct     1200

accgaaacgc tctgaaaatc gagccggagg agccgatcac tttctgtgag gaagccttcg     1260

tgtcccacta ccgctccgga gccatgaggc agttcctgca gaacgccaca cagctgcagc     1320

tcttcaagca gtttattgat ggtcgattag atcttctcaa ttccggcgaa ggtttcagtg     1380

atgtttttga agaggaaatc aacatgggcg agtacgctgg cagtgacaaa ctgtaccatc     1440

agtggctctc cactgtccgg aaaggaagtg gagcaattct gaatactgta aagaccaaag     1500

caaatccggc catgaagact gtctacaagt tcgcaaaaga tcatgcaaaa atgggaataa     1560

aagaggtgaa aaaccgcttg aagcaaaagg acattgccga gaatggctgc gcccccaccc     1620

cagaagagca gctgccaaag actgcaccgt ccccactggt ggaggccaag gaccccaagc     1680

tccgagaaga ccggcggcca atcacagtcc actttggaca ggtgcgccca cctcgtccac     1740

atgttgttaa gagaccaaag agcaacatcg cagtggaagg ccggaggacg tctgtgccga     1800

gccctgagca aaacaccatt gcaacaccag ctacactcca catcctacag aaaagcatta     1860

cccattttgc ggccaagttc ccgacgagag gctggacctc ttcatcacat tgacttacgc     1920

cgttgctttt ccagactggg cagaggggct gacttcgcag tgtgtgccaa agagccggtg     1980

tctgataatc ccattttcct gcttatcacc tgaactgtgt cagtatcact tttagttttg     2040

ttggttggtt ggtttgttgt ttgtttaata tgccctgttt tctacttctg ttggaaaata     2100

tttggggttg aaataaacca gtgggagcat ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2160

aaaaaa                                                                2166


<210>  2
<211>  559
<212>  PRT
<213>  Human

<400>  2

Met Gly Ser Arg Ile Lys Gln Asn Pro Glu Thr Thr Phe Glu Val Tyr 
1               5                   10                  15      


Val Glu Val Ala Tyr Pro Arg Thr Gly Gly Thr Leu Ser Asp Pro Glu 
            20                  25                  30          


Val Gln Arg Gln Phe Pro Glu Asp Tyr Ser Asp Gln Glu Val Leu Gln 
        35                  40                  45              


Thr Leu Thr Lys Phe Cys Phe Pro Phe Tyr Val Asp Ser Leu Thr Val 
    50                  55                  60                  


Ser Gln Val Gly Gln Asn Phe Thr Phe Val Leu Thr Asp Ile Asp Ser 
65                  70                  75                  80  


Lys Gln Arg Phe Gly Phe Cys Arg Leu Ser Ser Gly Ala Lys Ser Cys 
                85                  90                  95      


Phe Cys Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Phe Tyr Lys Leu 
            100                 105                 110         


Leu Asn Ile Leu Ala Asp Tyr Thr Thr Lys Arg Gln Glu Asn Gln Trp 
        115                 120                 125             


Asn Glu Leu Leu Glu Thr Leu His Lys Leu Pro Ile Pro Asp Pro Gly 
    130                 135                 140                 


Val Ser Val His Leu Ser Val His Ser Tyr Phe Thr Val Pro Asp Thr 
145                 150                 155                 160 


Arg Glu Leu Pro Ser Ile Pro Glu Asn Arg Asn Leu Thr Glu Tyr Phe 
                165                 170                 175     


Val Ala Val Asp Val Asn Asn Met Leu His Leu Tyr Ala Ser Met Leu 
            180                 185                 190         


Tyr Glu Arg Arg Ile Leu Ile Ile Cys Ser Lys Leu Ser Thr Leu Thr 
        195                 200                 205             


Ala Cys Ile His Gly Ser Ala Ala Met Leu Tyr Pro Met Tyr Trp Gln 
    210                 215                 220                 


His Val Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr Cys Cys 
225                 230                 235                 240 


Ala Pro Met Pro Tyr Leu Ile Gly Ile His Leu Ser Leu Met Glu Lys 
                245                 250                 255     


Val Arg Asn Met Ala Leu Asp Asp Val Val Ile Leu Asn Val Asp Thr 
            260                 265                 270         


Asn Thr Leu Glu Thr Pro Phe Asp Asp Leu Gln Ser Leu Pro Asn Asp 
        275                 280                 285             


Val Ile Ser Ser Leu Lys Asn Arg Leu Lys Lys Val Ser Thr Thr Thr 
    290                 295                 300                 


Gly Asp Gly Val Ala Arg Ala Phe Leu Lys Ala Gln Ala Ala Phe Phe 
305                 310                 315                 320 


Gly Ser Tyr Arg Asn Ala Leu Lys Ile Glu Pro Glu Glu Pro Ile Thr 
                325                 330                 335     


Phe Cys Glu Glu Ala Phe Val Ser His Tyr Arg Ser Gly Ala Met Arg 
            340                 345                 350         


Gln Phe Leu Gln Asn Ala Thr Gln Leu Gln Leu Phe Lys Gln Phe Ile 
        355                 360                 365             


Asp Gly Arg Leu Asp Leu Leu Asn Ser Gly Glu Gly Phe Ser Asp Val 
    370                 375                 380                 


Phe Glu Glu Glu Ile Asn Met Gly Glu Tyr Ala Gly Ser Asp Lys Leu 
385                 390                 395                 400 


Tyr His Gln Trp Leu Ser Thr Val Arg Lys Gly Ser Gly Ala Ile Leu 
                405                 410                 415     


Asn Thr Val Lys Thr Lys Ala Asn Pro Ala Met Lys Thr Val Tyr Lys 
            420                 425                 430         


Phe Ala Lys Asp His Ala Lys Met Gly Ile Lys Glu Val Lys Asn Arg 
        435                 440                 445             


Leu Lys Gln Lys Asp Ile Ala Glu Asn Gly Cys Ala Pro Thr Pro Glu 
    450                 455                 460                 


Glu Gln Leu Pro Lys Thr Ala Pro Ser Pro Leu Val Glu Ala Lys Asp 
465                 470                 475                 480 


Pro Lys Leu Arg Glu Asp Arg Arg Pro Ile Thr Val His Phe Gly Gln 
                485                 490                 495     


Val Arg Pro Pro Arg Pro His Val Val Lys Arg Pro Lys Ser Asn Ile 
            500                 505                 510         


Ala Val Glu Gly Arg Arg Thr Ser Val Pro Ser Pro Glu Gln Asn Thr 
        515                 520                 525             


Ile Ala Thr Pro Ala Thr Leu His Ile Leu Gln Lys Ser Ile Thr His 
    530                 535                 540                 


Phe Ala Ala Lys Phe Pro Thr Arg Gly Trp Thr Ser Ser Ser His 
545                 550                 555                 


<210>  3
<211>  5041
<212>  DNA
<213>  Human

<400>  3
cgcgcgccgg gcacgcgcgc cggcgaccat ggcgttcgcc gggctggagc gagtacatta       60

acccctggag gcggcggcgg cggcgaggga gcgagcctcg agcgggcggg ccccagcctg      120

agggaaggga ggaaggggcg gggagagcgc cagagggagg ccggtcggcc gcgggcgggc      180

gggcagcgca gcgccgagcg gggcccgcgg gcccatgagg aggcctgggg accatgggct      240

ccaggatcaa gcagaatcca gagaccacat ttgaagtata tgttgaagtg gcctatccca      300

ggacaggtgg cactctttca gatcctgagg tgcagaggca attcccggag gactacagtg      360

accaggaagt tctacagact ttgaccaagt tttgtttccc cttctatgtg gacagcctca      420

cagttagcca agttggccag aacttcacat tcgtgctcac tgacattgac agcaaacaga      480

gattcgggtt ctgccgctta tcttcaggag cgaagagctg cttctgtatc ttaagctatc      540

tcccctggtt cgaggtattt tataagctgc ttaacatcct ggcagattac acgacaaaaa      600

gacaggaaaa tcagtggaat gagcttcttg aaactctgca caaacttccc atccctgacc      660

caggagtgtc tgtccatctc agcgtgcatt cttattttac tgtgcctgat accagagaac      720

ttcccagcat acctgagaat agaaatctga cagaatattt tgtggctgtg gatgttaaca      780

acatgttgca tctgtacgcc agtatgctgt acgaacgccg gatactcatc atttgcagca      840

aactcagcac tctgactgcc tgcatccacg ggtctgcggc gatgctctac cccatgtact      900

ggcagcacgt gtacatcccc gtgctgccgc cgcatctgct ggactactgc tgtgctccca      960

tgccctacct cataggaatc catttaagtt taatggagaa agtcagaaac atggccctgg     1020

atgatgtcgt gatcctgaat gtggacacca acaccctgga aacccccttc gatgacctcc     1080

agagcctccc aaacgacgtg atctcttccc tgaagaacag gctgaaaaag gtctccacaa     1140

ccactgggga tggtgtggcc agagcgttcc tcaaggccca ggctgctttc ttcggtagct     1200

accgaaacgc tctgaaaatc gagccggagg agccgatcac tttctgtgag gaagccttcg     1260

tgtcccacta ccgctccgga gccatgaggc agttcctgca gaacgccaca cagctgcagc     1320

tcttcaagca gtttattgat ggtcgattag atcttctcaa ttccggcgaa ggtttcagtg     1380

atgtttttga agaggaaatc aacatgggcg agtacgctgg cagtgacaaa ctgtaccatc     1440

agtggctctc cactgtccgg aaaggaagtg gagcaattct gaatactgta aagaccaaag     1500

caaatccggc catgaagact gtctacaagt tcgcaaaaga tcatgcaaaa atgggaataa     1560

aagaggtgaa aaaccgcttg aagcaaaagg acattgccga gaatggctgc gcccccaccc     1620

cagaagagca gctgccaaag actgcaccgt ccccactggt ggaggccaag gaccccaagc     1680

tccgagaaga ccggcggcca atcacagtcc actttggaca ggtgcgccca cctcgtccac     1740

atgttgttaa gagaccaaag agcaacatcg cagtggaagg ccggaggacg tctgtgccga     1800

gccctgagca gccgcagccg tatcggacac tcagggagtc agacagcgcg gaaggcgacg     1860

aggcagagag tccagagcag caagtgcgga agtccacagg ccctgtccca gctccccctg     1920

accgggctgc cagcatcgac cttctggaag acgtcttcag caacctggac atggaggccg     1980

cactgcagcc actgggccag gccaagagct tagaggacct tcgtgccccc aaagacctga     2040

gggagcagcc agggaccttt gactatcaga ggctggatct gggcgggagt gagaggagcc     2100

gcggggtgac agtggccttg aagcttaccc acccgtacaa caagctctgg agcctgggcc     2160

aggacgacat ggccatcccc agcaagcccc cagctgcctc ccctgagaag ccctcggccc     2220

tgctcgggaa ctccctggcc ctgcctcgaa ggccccagaa ccgggacagc atcctgaacc     2280

ccagtgacaa ggaggaggtg cccaccccta ctctgggcag catcaccatc ccccggcccc     2340

aaggcaggaa gaccccagag ctgggcatcg tgcctccacc gcccattccc cgcccggcca     2400

agctccaggc tgccggcgcc gcacttggtg acgtctcaga gcggctgcag acggatcggg     2460

acaggcgagc tgccctgagt ccagggctcc tgcctggtgt tgtcccccaa ggccccactg     2520

aactgctcca gccgctcagc cctggccccg gggctgcagg cacgagcagt gacgccctgc     2580

tcgccctcct ggacccgctc agcacagcct ggtcaggcag caccctcccg tcacgccccg     2640

ccaccccgaa tgtagccacc ccattcaccc cccaattcag cttcccccct gcagggacac     2700

ccaccccatt cccacagcca ccactcaacc cctttgtccc atccatgcca gcagccccac     2760

ccaccctgcc cctggtctcc acaccagccg ggcctttcgg ggcccctcca gcttccctgg     2820

ggccggcttt tgcgtccggc ctcctgctgt ccagtgctgg cttctgtgcc cctcacaggt     2880

ctcagcccaa cctctccgcc ctctccatgc ccaacctctt tggccagatg cccatgggca     2940

cccacacgag ccccctacag ccgctgggtc ccccagcagt tgccccgtcg aggatccgaa     3000

cgttgcccct ggcccgctca agtgccaggg ctgctgagac caagcagggg ctggccctga     3060

ggcctggaga ccccccgctt ctgcctccca ggccccctca aggcctggag ccaacactgc     3120

agccctctgc tcctcaacag gccagagacc cctttgagga tttgttacag aaaaccaagc     3180

aagacgtgag cccgagtccg gccctggccc cggccccaga ctcggtggag cagctcagga     3240

agcagtggga gaccttcgag tgagccgggc cctgagggtg ggggatgcac cgaggcccga     3300

gggtccgtcc actgctgcgg ttccgaggct cccccgccac tctctctctg cccaggttct     3360

gctggtggga agggatggga cccctctctg ctgccccctc ctcccctcca cactgcccat     3420

ctctgatgtc tggccctggg gaatggcacc agttccagcc tgggaatcaa cccagttcct     3480

gagtgcccat cccaccccgc ggttgcctct cctcggcacc cttgattggg ttttgcacta     3540

aagaggtcag ctgggccaat gatattgctc cagaccgagt cctacccacc ttcccccgga     3600

agtgtcccaa gaggctccga aggcctcccc tccgagccca gctctcctgt ctcctccaca     3660

gccaggccct gcacgcccac ctcctcggac acaggtgaca gggttaccct ccagtttgag     3720

ctcatctgca cgagacacag gtagcttggg gttgaagtta ggactcctcc tgggctggag     3780

gatttacctg gtggggcact tccagactgt ttctagcaat atacacacac gttctttcct     3840

gtgtcttcac cccaaaactt cagttgattc tgacctggga ggatctgggg accagggggt     3900

cttgggctgc cttgtgatac acagccccag ccaccctgca cgggggctgc gagcaccagc     3960

aactttgatt tatagaagga aaatggaaac ccccatctga gtattttggg aggagccccc     4020

agccctcatc cagctctggc acgctgatac ctccaggtac tcccctcact gtcaaagctg     4080

gggctcagcc tcttgtcatc tggagctttg tgggcaaagc tgagaagctg caacccagat     4140

ttcaacccaa aaaggtcaag ctgaatgcct cagactgatg tggaaggcag ctggccttcc     4200

tgggttggaa cgaggcagtg gccctgagcc ccttctccag ggccaggtag aaaggacaaa     4260

cttggtctct gcctcgggga agcaggagga gggctagaag ccagtccctc cccacctgcc     4320

cagagctcca ggccagcaca gaaattcctg aggccaacgt caccaaagtt agattgaatg     4380

tttattatct ttctttttcc tttttacctt attgatttga tgaatcttga aatggattca     4440

tttccataaa ccaagttaaa gtatggcccg accatttaag aaaacaacca tctgagacac     4500

gcaggaaatt gtgagcattt cgacccgagc tctcatttcc tatttgtgaa gggtcagaca     4560

cagtctaccc aggggtgtct gggggacaag ggggtctctg gagatgtcac ccagggagcc     4620

ccctctatgt ctgagaggct gccactgctg cacatgctca gtgaggcttg gcggccatcc     4680

tggcacatgg ctcttcctgg gtcaaccgtg acctgtctgg ctcaggaatg ggctctggct     4740

gctgggggag ccgtgtcact cctgggccat gggggcacct cctgggcact taggtgtttc     4800

agcatagatt ccagtttcgc accctgggca gacccccagg ccccatccgg gatagggcag     4860

aggaggtgct ggcggcccca gggaaggagg gtgtgtaccc caaggccccc tggctgtgct     4920

gaggggctgg ggtgagcgct ccatgttcac atgagcactg ctgcctcttc acttgtggga     4980

ctttttgcaa acccaaggat gaactttgtg tgcattcaat aaaatcatct tggggaagag     5040

g                                                                     5041


<210>  4
<211>  1009
<212>  PRT
<213>  Human

<400>  4

Met Gly Ser Arg Ile Lys Gln Asn Pro Glu Thr Thr Phe Glu Val Tyr 
1               5                   10                  15      


Val Glu Val Ala Tyr Pro Arg Thr Gly Gly Thr Leu Ser Asp Pro Glu 
            20                  25                  30          


Val Gln Arg Gln Phe Pro Glu Asp Tyr Ser Asp Gln Glu Val Leu Gln 
        35                  40                  45              


Thr Leu Thr Lys Phe Cys Phe Pro Phe Tyr Val Asp Ser Leu Thr Val 
    50                  55                  60                  


Ser Gln Val Gly Gln Asn Phe Thr Phe Val Leu Thr Asp Ile Asp Ser 
65                  70                  75                  80  


Lys Gln Arg Phe Gly Phe Cys Arg Leu Ser Ser Gly Ala Lys Ser Cys 
                85                  90                  95      


Phe Cys Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Phe Tyr Lys Leu 
            100                 105                 110         


Leu Asn Ile Leu Ala Asp Tyr Thr Thr Lys Arg Gln Glu Asn Gln Trp 
        115                 120                 125             


Asn Glu Leu Leu Glu Thr Leu His Lys Leu Pro Ile Pro Asp Pro Gly 
    130                 135                 140                 


Val Ser Val His Leu Ser Val His Ser Tyr Phe Thr Val Pro Asp Thr 
145                 150                 155                 160 


Arg Glu Leu Pro Ser Ile Pro Glu Asn Arg Asn Leu Thr Glu Tyr Phe 
                165                 170                 175     


Val Ala Val Asp Val Asn Asn Met Leu His Leu Tyr Ala Ser Met Leu 
            180                 185                 190         


Tyr Glu Arg Arg Ile Leu Ile Ile Cys Ser Lys Leu Ser Thr Leu Thr 
        195                 200                 205             


Ala Cys Ile His Gly Ser Ala Ala Met Leu Tyr Pro Met Tyr Trp Gln 
    210                 215                 220                 


His Val Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr Cys Cys 
225                 230                 235                 240 


Ala Pro Met Pro Tyr Leu Ile Gly Ile His Leu Ser Leu Met Glu Lys 
                245                 250                 255     


Val Arg Asn Met Ala Leu Asp Asp Val Val Ile Leu Asn Val Asp Thr 
            260                 265                 270         


Asn Thr Leu Glu Thr Pro Phe Asp Asp Leu Gln Ser Leu Pro Asn Asp 
        275                 280                 285             


Val Ile Ser Ser Leu Lys Asn Arg Leu Lys Lys Val Ser Thr Thr Thr 
    290                 295                 300                 


Gly Asp Gly Val Ala Arg Ala Phe Leu Lys Ala Gln Ala Ala Phe Phe 
305                 310                 315                 320 


Gly Ser Tyr Arg Asn Ala Leu Lys Ile Glu Pro Glu Glu Pro Ile Thr 
                325                 330                 335     


Phe Cys Glu Glu Ala Phe Val Ser His Tyr Arg Ser Gly Ala Met Arg 
            340                 345                 350         


Gln Phe Leu Gln Asn Ala Thr Gln Leu Gln Leu Phe Lys Gln Phe Ile 
        355                 360                 365             


Asp Gly Arg Leu Asp Leu Leu Asn Ser Gly Glu Gly Phe Ser Asp Val 
    370                 375                 380                 


Phe Glu Glu Glu Ile Asn Met Gly Glu Tyr Ala Gly Ser Asp Lys Leu 
385                 390                 395                 400 


Tyr His Gln Trp Leu Ser Thr Val Arg Lys Gly Ser Gly Ala Ile Leu 
                405                 410                 415     


Asn Thr Val Lys Thr Lys Ala Asn Pro Ala Met Lys Thr Val Tyr Lys 
            420                 425                 430         


Phe Ala Lys Asp His Ala Lys Met Gly Ile Lys Glu Val Lys Asn Arg 
        435                 440                 445             


Leu Lys Gln Lys Asp Ile Ala Glu Asn Gly Cys Ala Pro Thr Pro Glu 
    450                 455                 460                 


Glu Gln Leu Pro Lys Thr Ala Pro Ser Pro Leu Val Glu Ala Lys Asp 
465                 470                 475                 480 


Pro Lys Leu Arg Glu Asp Arg Arg Pro Ile Thr Val His Phe Gly Gln 
                485                 490                 495     


Val Arg Pro Pro Arg Pro His Val Val Lys Arg Pro Lys Ser Asn Ile 
            500                 505                 510         


Ala Val Glu Gly Arg Arg Thr Ser Val Pro Ser Pro Glu Gln Pro Gln 
        515                 520                 525             


Pro Tyr Arg Thr Leu Arg Glu Ser Asp Ser Ala Glu Gly Asp Glu Ala 
    530                 535                 540                 


Glu Ser Pro Glu Gln Gln Val Arg Lys Ser Thr Gly Pro Val Pro Ala 
545                 550                 555                 560 


Pro Pro Asp Arg Ala Ala Ser Ile Asp Leu Leu Glu Asp Val Phe Ser 
                565                 570                 575     


Asn Leu Asp Met Glu Ala Ala Leu Gln Pro Leu Gly Gln Ala Lys Ser 
            580                 585                 590         


Leu Glu Asp Leu Arg Ala Pro Lys Asp Leu Arg Glu Gln Pro Gly Thr 
        595                 600                 605             


Phe Asp Tyr Gln Arg Leu Asp Leu Gly Gly Ser Glu Arg Ser Arg Gly 
    610                 615                 620                 


Val Thr Val Ala Leu Lys Leu Thr His Pro Tyr Asn Lys Leu Trp Ser 
625                 630                 635                 640 


Leu Gly Gln Asp Asp Met Ala Ile Pro Ser Lys Pro Pro Ala Ala Ser 
                645                 650                 655     


Pro Glu Lys Pro Ser Ala Leu Leu Gly Asn Ser Leu Ala Leu Pro Arg 
            660                 665                 670         


Arg Pro Gln Asn Arg Asp Ser Ile Leu Asn Pro Ser Asp Lys Glu Glu 
        675                 680                 685             


Val Pro Thr Pro Thr Leu Gly Ser Ile Thr Ile Pro Arg Pro Gln Gly 
    690                 695                 700                 


Arg Lys Thr Pro Glu Leu Gly Ile Val Pro Pro Pro Pro Ile Pro Arg 
705                 710                 715                 720 


Pro Ala Lys Leu Gln Ala Ala Gly Ala Ala Leu Gly Asp Val Ser Glu 
                725                 730                 735     


Arg Leu Gln Thr Asp Arg Asp Arg Arg Ala Ala Leu Ser Pro Gly Leu 
            740                 745                 750         


Leu Pro Gly Val Val Pro Gln Gly Pro Thr Glu Leu Leu Gln Pro Leu 
        755                 760                 765             


Ser Pro Gly Pro Gly Ala Ala Gly Thr Ser Ser Asp Ala Leu Leu Ala 
    770                 775                 780                 


Leu Leu Asp Pro Leu Ser Thr Ala Trp Ser Gly Ser Thr Leu Pro Ser 
785                 790                 795                 800 


Arg Pro Ala Thr Pro Asn Val Ala Thr Pro Phe Thr Pro Gln Phe Ser 
                805                 810                 815     


Phe Pro Pro Ala Gly Thr Pro Thr Pro Phe Pro Gln Pro Pro Leu Asn 
            820                 825                 830         


Pro Phe Val Pro Ser Met Pro Ala Ala Pro Pro Thr Leu Pro Leu Val 
        835                 840                 845             


Ser Thr Pro Ala Gly Pro Phe Gly Ala Pro Pro Ala Ser Leu Gly Pro 
    850                 855                 860                 


Ala Phe Ala Ser Gly Leu Leu Leu Ser Ser Ala Gly Phe Cys Ala Pro 
865                 870                 875                 880 


His Arg Ser Gln Pro Asn Leu Ser Ala Leu Ser Met Pro Asn Leu Phe 
                885                 890                 895     


Gly Gln Met Pro Met Gly Thr His Thr Ser Pro Leu Gln Pro Leu Gly 
            900                 905                 910         


Pro Pro Ala Val Ala Pro Ser Arg Ile Arg Thr Leu Pro Leu Ala Arg 
        915                 920                 925             


Ser Ser Ala Arg Ala Ala Glu Thr Lys Gln Gly Leu Ala Leu Arg Pro 
    930                 935                 940                 


Gly Asp Pro Pro Leu Leu Pro Pro Arg Pro Pro Gln Gly Leu Glu Pro 
945                 950                 955                 960 


Thr Leu Gln Pro Ser Ala Pro Gln Gln Ala Arg Asp Pro Phe Glu Asp 
                965                 970                 975     


Leu Leu Gln Lys Thr Lys Gln Asp Val Ser Pro Ser Pro Ala Leu Ala 
            980                 985                 990         


Pro Ala Pro Asp Ser Val Glu Gln  Leu Arg Lys Gln Trp  Glu Thr Phe 
        995                 1000                 1005             


Glu 
    


<210>  5
<211>  356
<212>  DNA
<213>  Human

<400>  5
aaacaccatt gcaacaccag ctacactcca catcctacag aaaagcatta cccattttgc       60

ggccaagttc ccgacgagag gctggacctc ttcatcacat tgacttacgc cgttgctttt      120

ccagactggg cagaggggct gacttcgcag tgtgtgccaa agagccggtg tctgataatc      180

ccattttcct gcttatcacc tgaactgtgt cagtatcact tttagttttg ttggttggtt      240

ggtttgttgt ttgtttaata tgccctgttt tctacttctg ttggaaaata tttggggttg      300

aaataaacca gtgggagcat ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa          356


<210>  6
<211>  322
<212>  DNA
<213>  Human

<400>  6
aaacaccatt gcaacaccag ctacactcca catcctacag aaaagcatta cccattttgc       60

ggccaagttc ccgacgagag gctggacctc ttcatcacat tgacttacgc cgttgctttt      120

ccagactggg cagaggggct gacttcgcag tgtgtgccaa agagccggtg tctgataatc      180

ccattttcct gcttatcacc tgaactgtgt cagtatcact tttagttttg ttggttggtt      240

ggtttgttgt ttgtttaata tgccctgttt tctacttctg ttggaaaata tttggggttg      300

aaataaacca gtgggagcat gg                                               322


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  7
gggctgactt cgcagtgtgt                                                   20


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  8
acagttcagg tgataagcag gaaa                                              24


<210>  9
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe

<400>  9
ccaaagagcc ggtgtctgat aatccca                                           27


<210>  10
<211>  33
<212>  PRT
<213>  Human

<400>  10

Asn Thr Ile Ala Thr Pro Ala Thr Leu His Ile Leu Gln Lys Ser Ile 
1               5                   10                  15      


Thr His Phe Ala Ala Lys Phe Pro Thr Arg Gly Trp Thr Ser Ser Ser 
            20                  25                  30          


His 
    


<210>  11
<211>  21
<212>  PRT
<213>  Human

<400>  11

Gln Lys Ser Ile Thr His Phe Ala Ala Lys Phe Pro Thr Arg Gly Trp 
1               5                   10                  15      


Thr Ser Ser Ser His 
            20      


<210>  12
<211>  23
<212>  DNA
<213>  Human

<400>  12
cgacgagagg ctggacctct tac                                               23


<210>  13
<211>  19
<212>  DNA
<213>  Human

<400>  13
ctcttcatca cattgactt                                                    19


<210>  14
<211>  212
<212>  DNA
<213>  Human

<400>  14
cgttgctttt ccagactggg cagaggggct gacttcgcag tgtgtgccaa agagccggtg       60

tctgataatc ccattttcct gcttatcacc tgaactgtgt cagtatcact tttagttttg      120

ttggttggtt ggtttgttgt ttgtttaata tgccctgttt tctacttctg ttggaaaata      180

tttggggttg aaataaacca gtgggagcat gg                                    212


<210>  15
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  15
ggattcattt ccataaacca agttaaa                                           27


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  16
cacaatttcc tgcgtgtctc a                                                 21


<210>  17
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  17
atggcccgac catttaagaa aacaacca                                          28


<210>  18
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  18
ggcctcaaat ggcaactcta ga                                                22


<210>  19
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  19
cttctgatcg ccatccttga a                                                 21


<210>  20
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  probe

<400>  20
tcgcgtccaa caaccgtaag ggtatc                                            26


<210>  21
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  21
cacggcactg attttcagtt c                                                 21


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  22
tcttgctgcc agtctggact                                                   20


<210>  23
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe

<400>  23
tgtgcacagg agccaagagt gaaga                                             25


<210>  24
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  24
gcctccttca gcgtctac                                                     18


<210>  25
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  25
gtctcccatc caagtactaa cc                                                22


<210>  26
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  probe

<400>  26
tctcgtctga tctcggaagc taagca                                            26


