                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique
 
<120>  Laccase de Podospora anserina et ses applications

<130>  CB/es - F644 345WO

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  565
<212>  PRT
<213>  Podospora anserina

<400>  1

Val Ala Arg Lys Asp Trp Glu Ser Pro Thr Tyr Ser Trp Leu Tyr Gln 
1               5                   10                  15      


Phe Pro Leu Pro Ile Pro Pro Val Lys Thr Pro Lys Leu Thr Val Thr 
            20                  25                  30          


Asn Leu Val Thr Gly Asn Pro Ile His Tyr Tyr Glu Val Tyr Ile Asn 
        35                  40                  45              


Arg Phe Thr Gln Gln Val Tyr Pro Asn Lys Gly Pro Ala Thr Leu Val 
    50                  55                  60                  


Gly Tyr Asp Gly Ile Ser Pro Gly Pro Thr Phe Ile Val Glu Arg Gly 
65                  70                  75                  80  


His Glu Ala Val Val Arg Phe Val Asn Asn Ala Ser Ile Glu Asn Ser 
                85                  90                  95      


Val His Leu His Gly Ser Tyr Ser Arg Ala Pro Trp Asp Gly Trp Ala 
            100                 105                 110         


Glu Asp Val Thr Met Pro Gly Glu Phe Lys Asp Tyr Tyr Tyr Pro Asn 
        115                 120                 125             


Gln Gln Ala Ala Arg Phe Leu Trp Tyr His Asp His Ala Phe Met His 
    130                 135                 140                 


Thr Ala Glu Asn Ala Tyr Phe Gly Gln Ala Gly Ala Tyr Ile Ile His 
145                 150                 155                 160 


Asp Pro Ala Glu Asp Ala Leu Asn Leu Pro Ser Gly Tyr Gly Val His 
                165                 170                 175     


Asp Ile Pro Leu Val Leu Ser Ser Lys Gln Tyr Asn Asn Asn Gly Ser 
            180                 185                 190         


Leu Phe Thr Thr Asn Gly Glu Thr Asp Ser Leu Phe Gly Asp Val Ile 
        195                 200                 205             


His Val Asn Gly Gln Pro Trp Pro Tyr Phe Asn Val Glu Pro Arg Lys 
    210                 215                 220                 


Tyr Arg Leu Arg Phe Leu Asp Ala Ala Val Ser Arg Thr Phe Lys Leu 
225                 230                 235                 240 


Tyr Phe Gln Arg Gln Thr Gly Ser Ser Ala Lys Ile Pro Phe Gln Val 
                245                 250                 255     


Ile Ala Thr Asp Ala Gly Leu Met Ala Ser Pro Ala Thr Thr Asn Asp 
            260                 265                 270         


Leu Tyr Ile Ser Met Gly Glu Arg Tyr Glu Val Val Phe Asp Phe Ser 
        275                 280                 285             


Pro Phe Ala Gly Gln Asn Ile Thr Leu Arg Asn Thr Asp Asp Val Gly 
    290                 295                 300                 


Gln Asp Asp Asp Tyr Leu His Thr Asn Lys Val Met Arg Phe Ile Val 
305                 310                 315                 320 


Gly Asn Thr Pro Val Thr Asp Thr Ser Ser Ile Pro Ser Thr Leu Ala 
                325                 330                 335     


Thr Val Asp Trp Pro Thr Ser Asp Gly Thr Gly Val Asp Arg His Phe 
            340                 345                 350         


Lys Phe Asp Arg Ser Asn Gly Glu Trp Gln Ile Asn Gly Val Val Phe 
        355                 360                 365             


Ala Asp Val Asn Asn Arg Val Leu Ala Asn Val Pro Arg Gly Lys Val 
    370                 375                 380                 


Glu Ile Trp Glu Leu Glu Asn Gly Gly Gly Gly Trp Ser His Pro Ile 
385                 390                 395                 400 


His Ile His Leu Val Asp Phe Lys Val Leu Trp Arg Ser Asn Asp Asp 
                405                 410                 415     


Gly Arg Pro Val Tyr Asn Tyr Glu Ala Gln Gly Leu Lys Asp Val Val 
            420                 425                 430         


Trp Leu Ala Pro Asn Glu Ile Val Arg Val Glu Ala His Tyr Ala Pro 
        435                 440                 445             


Trp Asp Gly Val Tyr Met Phe His Cys His Asn Leu Ile His Glu Asp 
    450                 455                 460                 


His Asp Met Met Ala Ala Phe Asn Val Thr Ala Leu Thr Asp Leu Gly 
465                 470                 475                 480 


Tyr Asn Glu Thr Ala Phe Arg Asp Pro Met Glu Ala Arg Trp Arg Ala 
                485                 490                 495     


Glu Pro Val Thr Ala Ala Lys Phe Thr Thr Ala Ala Ile Thr Glu Lys 
            500                 505                 510         


Ile Gln Phe Met Ala Gly Leu Gln Pro Tyr Asn Asn Val Glu Glu Val 
        515                 520                 525             


Leu Glu Val Leu Asp Glu Tyr Trp Ala Thr His Ser Lys Arg Asp Ala 
    530                 535                 540                 


Gln Asp Pro Ala Pro Lys Thr Arg Arg Met Arg Ile Glu Gly Gly Lys 
545                 550                 555                 560 


Val Lys Glu Val Arg 
                565 


<210>  2
<211>  1788
<212>  DNA
<213>  Podospora anserina

<400>  2
atgttgtcca tcctcacttc cgctcttctc gccgtctcgg cctcgcctgt tgtcttgggt       60

cgggctacgc ctgagcaaaa gcacaagctg gtcgccagaa aggattggga gagtcctacc      120

tattcgtggc tttaccaatt tcctctgcct attcctccgg tcaagacgcc caaactgacc      180

gttaccaacc tggtgactgg caaccccatt cactattacg aggtctacat caaccggttc      240

acccaacaag tgtatccaaa caagggtccc gcaactcttg ttggttacga cggcatctct      300

cccggcccga cctttatcgt ggagagaggt catgaggctg ttgtgcgctt cgtcaacaat      360

gccagcatcg aaaactcggt ccatctccac gggtcatact ctcgcgctcc ttgggatggt      420

tgggcagagg atgtgaccat gccaggcgag ttcaaggact actactatcc caaccaacag      480

gcggcccgtt tcctgtggta ccacgatcac gcattcatgc atactgctga gaatgcatat      540

tttggccaag ctggggccta cattattcat gatcctgctg aagacgcctt gaaccttccc      600

tcaggttacg gtgttcatga tattcctctg gtgctctctt ccaagcagta caacaacaat      660

ggcagtctgt tcaccaccaa tggtgagacg gactcgctct ttggcgatgt tatccacgtc      720

aacggccagc cctggcccta cttcaacgtt gagcctcgca agtaccgcct ccgcttcctc      780

gacgctgccg tctcacgcac cttcaagctc tacttccagc gtcaaactgg cagctcagcc      840

aagattcctt tccaagtcat tgccacagat gccggcttga tggcctcacc agccaccaca      900

aacgaccttt acatcagcat gggagagcgg tacgaggttg tctttgactt ttcgcccttt      960

gctggccaaa acatcacctt gcgcaacacg gacgacgtgg gccaggacga cgattacctc     1020

cacaccaaca aggtcatgag attcatcgtt ggcaacaccc cagtgaccga caccagctcc     1080

attcccagca ctctggctac tgtcgactgg ccgacctctg atggaaccgg tgtggacaga     1140

cactttaagt ttgaccgctc caatggcgag tggcagatca acggagtcgt ctttgccgat     1200

gtcaacaacc gtgtgcttgc caatgtcccc cgcggcaagg ttgaaatttg ggagctcgag     1260

aacggcggcg gcggatggag ccacccaatc cacattcacc tggtcgactt caaagtcttg     1320

tggcgctcga atgacgatgg cagaccggtc tacaactacg aggcccaggg tttgaaggat     1380

gttgtctggc ttgcgcccaa cgagattgtc agagtggagg cccactacgc cccatgggac     1440

ggagtctaca tgttccactg ccacaacctg attcacgagg atcacgacat gatggctgcc     1500

ttcaacgtca ctgctctgac tgacttggga tacaacgaga ccgcgttccg tgaccccatg     1560

gaggccagat ggagagccga gccggtcacg gctgccaagt tcaccacggc tgccatcacc     1620

gaaaagattc agttcatggc cggactgcag ccctacaaca atgtcgagga agtcttggag     1680

gttctcgacg agtactgggc cacgcacagc aagcgtgacg cccaagaccc tgctcccaag     1740

accagaagaa tgagaattga gggcgggaag gtcaaagagg tccggtga                  1788


<210>  3
<211>  566
<212>  PRT
<213>  Podospora anserina

<400>  3

Ser Val Ala Arg Lys Asp Trp Glu Ser Pro Thr Tyr Ser Trp Leu Tyr 
1               5                   10                  15      


Gln Phe Pro Leu Pro Ile Pro Pro Val Lys Thr Pro Lys Leu Thr Val 
            20                  25                  30          


Thr Asn Leu Val Thr Gly Asn Pro Ile His Tyr Tyr Glu Val Tyr Ile 
        35                  40                  45              


Asn Arg Phe Thr Gln Gln Val Tyr Pro Asn Lys Gly Pro Ala Thr Leu 
    50                  55                  60                  


Val Gly Tyr Asp Gly Ile Ser Pro Gly Pro Thr Phe Ile Val Glu Arg 
65                  70                  75                  80  


Gly His Glu Ala Val Val Arg Phe Val Asn Asn Ala Ser Ile Glu Asn 
                85                  90                  95      


Ser Val His Leu His Gly Ser Tyr Ser Arg Ala Pro Trp Asp Gly Trp 
            100                 105                 110         


Ala Glu Asp Val Thr Met Pro Gly Glu Phe Lys Asp Tyr Tyr Tyr Pro 
        115                 120                 125             


Asn Gln Gln Ala Ala Arg Phe Leu Trp Tyr His Asp His Ala Phe Met 
    130                 135                 140                 


His Thr Ala Glu Asn Ala Tyr Phe Gly Gln Ala Gly Ala Tyr Ile Ile 
145                 150                 155                 160 


His Asp Pro Ala Glu Asp Ala Leu Asn Leu Pro Ser Gly Tyr Gly Val 
                165                 170                 175     


His Asp Ile Pro Leu Val Leu Ser Ser Lys Gln Tyr Asn Asn Asn Gly 
            180                 185                 190         


Ser Leu Phe Thr Thr Asn Gly Glu Thr Asp Ser Leu Phe Gly Asp Val 
        195                 200                 205             


Ile His Val Asn Gly Gln Pro Trp Pro Tyr Phe Asn Val Glu Pro Arg 
    210                 215                 220                 


Lys Tyr Arg Leu Arg Phe Leu Asp Ala Ala Val Ser Arg Thr Phe Lys 
225                 230                 235                 240 


Leu Tyr Phe Gln Arg Gln Thr Gly Ser Ser Ala Lys Ile Pro Phe Gln 
                245                 250                 255     


Val Ile Ala Thr Asp Ala Gly Leu Met Ala Ser Pro Ala Thr Thr Asn 
            260                 265                 270         


Asp Leu Tyr Ile Ser Met Gly Glu Arg Tyr Glu Val Val Phe Asp Phe 
        275                 280                 285             


Ser Pro Phe Ala Gly Gln Asn Ile Thr Leu Arg Asn Thr Asp Asp Val 
    290                 295                 300                 


Gly Gln Asp Asp Asp Tyr Leu His Thr Asn Lys Val Met Arg Phe Ile 
305                 310                 315                 320 


Val Gly Asn Thr Pro Val Thr Asp Thr Ser Ser Ile Pro Ser Thr Leu 
                325                 330                 335     


Ala Thr Val Asp Trp Pro Thr Ser Asp Gly Thr Gly Val Asp Arg His 
            340                 345                 350         


Phe Lys Phe Asp Arg Ser Asn Gly Glu Trp Gln Ile Asn Gly Val Val 
        355                 360                 365             


Phe Ala Asp Val Asn Asn Arg Val Leu Ala Asn Val Pro Arg Gly Lys 
    370                 375                 380                 


Val Glu Ile Trp Glu Leu Glu Asn Gly Gly Gly Gly Trp Ser His Pro 
385                 390                 395                 400 


Ile His Ile His Leu Val Asp Phe Lys Val Leu Trp Arg Ser Asn Asp 
                405                 410                 415     


Asp Gly Arg Pro Val Tyr Asn Tyr Glu Ala Gln Gly Leu Lys Asp Val 
            420                 425                 430         


Val Trp Leu Ala Pro Asn Glu Ile Val Arg Val Glu Ala His Tyr Ala 
        435                 440                 445             


Pro Trp Asp Gly Val Tyr Met Phe His Cys His Asn Leu Ile His Glu 
    450                 455                 460                 


Asp His Asp Met Met Ala Ala Phe Asn Val Thr Ala Leu Thr Asp Leu 
465                 470                 475                 480 


Gly Tyr Asn Glu Thr Ala Phe Arg Asp Pro Met Glu Ala Arg Trp Arg 
                485                 490                 495     


Ala Glu Pro Val Thr Ala Ala Lys Phe Thr Thr Ala Ala Ile Thr Glu 
            500                 505                 510         


Lys Ile Gln Phe Met Ala Gly Leu Gln Pro Tyr Asn Asn Val Glu Glu 
        515                 520                 525             


Val Leu Glu Val Leu Asp Glu Tyr Trp Ala Thr His Ser Lys Arg Asp 
    530                 535                 540                 


Ala Gln Asp Pro Ala Pro Lys Thr Arg Arg Met Arg Ile Glu Gly Gly 
545                 550                 555                 560 


Lys Val Lys Glu Val Arg 
                565     


<210>  4
<211>  1695
<212>  DNA
<213>  Podospora anserina

<400>  4
gtcgccagaa aggattggga gagtcctacc tattcgtggc tttaccaatt tcctctgcct       60

attcctccgg tcaagacgcc caaactgacc gttaccaacc tggtgactgg caaccccatt      120

cactattacg aggtctacat caaccggttc acccaacaag tgtatccaaa caagggtccc      180

gcaactcttg ttggttacga cggcatctct cccggcccga cctttatcgt ggagagaggt      240

catgaggctg ttgtgcgctt cgtcaacaat gccagcatcg aaaactcggt ccatctccac      300

gggtcatact ctcgcgctcc ttgggatggt tgggcagagg atgtgaccat gccaggcgag      360

ttcaaggact actactatcc caaccaacag gcggcccgtt tcctgtggta ccacgatcac      420

gcattcatgc atactgctga gaatgcatat tttggccaag ctggggccta cattattcat      480

gatcctgctg aagacgcctt gaaccttccc tcaggttacg gtgttcatga tattcctctg      540

gtgctctctt ccaagcagta caacaacaat ggcagtctgt tcaccaccaa tggtgagacg      600

gactcgctct ttggcgatgt tatccacgtc aacggccagc cctggcccta cttcaacgtt      660

gagcctcgca agtaccgcct ccgcttcctc gacgctgccg tctcacgcac cttcaagctc      720

tacttccagc gtcaaactgg cagctcagcc aagattcctt tccaagtcat tgccacagat      780

gccggcttga tggcctcacc agccaccaca aacgaccttt acatcagcat gggagagcgg      840

tacgaggttg tctttgactt ttcgcccttt gctggccaaa acatcacctt gcgcaacacg      900

gacgacgtgg gccaggacga cgattacctc cacaccaaca aggtcatgag attcatcgtt      960

ggcaacaccc cagtgaccga caccagctcc attcccagca ctctggctac tgtcgactgg     1020

ccgacctctg atggaaccgg tgtggacaga cactttaagt ttgaccgctc caatggcgag     1080

tggcagatca acggagtcgt ctttgccgat gtcaacaacc gtgtgcttgc caatgtcccc     1140

cgcggcaagg ttgaaatttg ggagctcgag aacggcggcg gcggatggag ccacccaatc     1200

cacattcacc tggtcgactt caaagtcttg tggcgctcga atgacgatgg cagaccggtc     1260

tacaactacg aggcccaggg tttgaaggat gttgtctggc ttgcgcccaa cgagattgtc     1320

agagtggagg cccactacgc cccatgggac ggagtctaca tgttccactg ccacaacctg     1380

attcacgagg atcacgacat gatggctgcc ttcaacgtca ctgctctgac tgacttggga     1440

tacaacgaga ccgcgttccg tgaccccatg gaggccagat ggagagccga gccggtcacg     1500

gctgccaagt tcaccacggc tgccatcacc gaaaagattc agttcatggc cggactgcag     1560

ccctacaaca atgtcgagga agtcttggag gttctcgacg agtactgggc cacgcacagc     1620

aagcgtgacg cccaagaccc tgctcccaag accagaagaa tgagaattga gggcgggaag     1680

gtcaaagagg tccgg                                                      1695


<210>  5
<211>  595
<212>  PRT
<213>  Podospora anserina

<400>  5

Met Leu Ser Ile Leu Thr Ser Ala Leu Leu Ala Val Ser Ala Ser Pro 
1               5                   10                  15      


Val Val Leu Gly Arg Ala Thr Pro Glu Gln Lys His Lys Leu Val Ala 
            20                  25                  30          


Arg Lys Asp Trp Glu Ser Pro Thr Tyr Ser Trp Leu Tyr Gln Phe Pro 
        35                  40                  45              


Leu Pro Ile Pro Pro Val Lys Thr Pro Lys Leu Thr Val Thr Asn Leu 
    50                  55                  60                  


Val Thr Gly Asn Pro Ile His Tyr Tyr Glu Val Tyr Ile Asn Arg Phe 
65                  70                  75                  80  


Thr Gln Gln Val Tyr Pro Asn Lys Gly Pro Ala Thr Leu Val Gly Tyr 
                85                  90                  95      


Asp Gly Ile Ser Pro Gly Pro Thr Phe Ile Val Glu Arg Gly His Glu 
            100                 105                 110         


Ala Val Val Arg Phe Val Asn Asn Ala Ser Ile Glu Asn Ser Val His 
        115                 120                 125             


Leu His Gly Ser Tyr Ser Arg Ala Pro Trp Asp Gly Trp Ala Glu Asp 
    130                 135                 140                 


Val Thr Met Pro Gly Glu Phe Lys Asp Tyr Tyr Tyr Pro Asn Gln Gln 
145                 150                 155                 160 


Ala Ala Arg Phe Leu Trp Tyr His Asp His Ala Phe Met His Thr Ala 
                165                 170                 175     


Glu Asn Ala Tyr Phe Gly Gln Ala Gly Ala Tyr Ile Ile His Asp Pro 
            180                 185                 190         


Ala Glu Asp Ala Leu Asn Leu Pro Ser Gly Tyr Gly Val His Asp Ile 
        195                 200                 205             


Pro Leu Val Leu Ser Ser Lys Gln Tyr Asn Asn Asn Gly Ser Leu Phe 
    210                 215                 220                 


Thr Thr Asn Gly Glu Thr Asp Ser Leu Phe Gly Asp Val Ile His Val 
225                 230                 235                 240 


Asn Gly Gln Pro Trp Pro Tyr Phe Asn Val Glu Pro Arg Lys Tyr Arg 
                245                 250                 255     


Leu Arg Phe Leu Asp Ala Ala Val Ser Arg Thr Phe Lys Leu Tyr Phe 
            260                 265                 270         


Gln Arg Gln Thr Gly Ser Ser Ala Lys Ile Pro Phe Gln Val Ile Ala 
        275                 280                 285             


Thr Asp Ala Gly Leu Met Ala Ser Pro Ala Thr Thr Asn Asp Leu Tyr 
    290                 295                 300                 


Ile Ser Met Gly Glu Arg Tyr Glu Val Val Phe Asp Phe Ser Pro Phe 
305                 310                 315                 320 


Ala Gly Gln Asn Ile Thr Leu Arg Asn Thr Asp Asp Val Gly Gln Asp 
                325                 330                 335     


Asp Asp Tyr Leu His Thr Asn Lys Val Met Arg Phe Ile Val Gly Asn 
            340                 345                 350         


Thr Pro Val Thr Asp Thr Ser Ser Ile Pro Ser Thr Leu Ala Thr Val 
        355                 360                 365             


Asp Trp Pro Thr Ser Asp Gly Thr Gly Val Asp Arg His Phe Lys Phe 
    370                 375                 380                 


Asp Arg Ser Asn Gly Glu Trp Gln Ile Asn Gly Val Val Phe Ala Asp 
385                 390                 395                 400 


Val Asn Asn Arg Val Leu Ala Asn Val Pro Arg Gly Lys Val Glu Ile 
                405                 410                 415     


Trp Glu Leu Glu Asn Gly Gly Gly Gly Trp Ser His Pro Ile His Ile 
            420                 425                 430         


His Leu Val Asp Phe Lys Val Leu Trp Arg Ser Asn Asp Asp Gly Arg 
        435                 440                 445             


Pro Val Tyr Asn Tyr Glu Ala Gln Gly Leu Lys Asp Val Val Trp Leu 
    450                 455                 460                 


Ala Pro Asn Glu Ile Val Arg Val Glu Ala His Tyr Ala Pro Trp Asp 
465                 470                 475                 480 


Gly Val Tyr Met Phe His Cys His Asn Leu Ile His Glu Asp His Asp 
                485                 490                 495     


Met Met Ala Ala Phe Asn Val Thr Ala Leu Thr Asp Leu Gly Tyr Asn 
            500                 505                 510         


Glu Thr Ala Phe Arg Asp Pro Met Glu Ala Arg Trp Arg Ala Glu Pro 
        515                 520                 525             


Val Thr Ala Ala Lys Phe Thr Thr Ala Ala Ile Thr Glu Lys Ile Gln 
    530                 535                 540                 


Phe Met Ala Gly Leu Gln Pro Tyr Asn Asn Val Glu Glu Val Leu Glu 
545                 550                 555                 560 


Val Leu Asp Glu Tyr Trp Ala Thr His Ser Lys Arg Asp Ala Gln Asp 
                565                 570                 575     


Pro Ala Pro Lys Thr Arg Arg Met Arg Ile Glu Gly Gly Lys Val Lys 
            580                 585                 590         


Glu Val Arg 
        595 


<210>  6
<211>  5245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construction plasmidique

<400>  6
ggccgccagc tttctagaac aaaaactcat ctcagaagag gatctgaata gcgccgtcga       60

ccatcatcat catcatcatt gagtttgtag ccttagacat gactgttcct cagttcaagt      120

tgggcactta cgagaagacc ggtcttgcta gattctaatc aagaggatgt cagaatgcca      180

tttgcctgag agatgcaggc ttcatttttg atactttttt atttgtaacc tatatagtat      240

aggatttttt ttgtcatttt gtttcttctc gtacgagctt gctcctgatc agcctatctc      300

gcagctgatg aatatcttgt ggtaggggtt tgggaaaatc attcgagttt gatgtttttc      360

ttggtatttc ccactcctct tcagagtaca gaagattaag tgagaccttc gtttgtgcgg      420

atcccccaca caccatagct tcaaaatgtt tctactcctt ttttactctt ccagattttc      480

tcggactccg cgcatcgccg taccacttca aaacacccaa gcacagcata ctaaattttc      540

cctctttctt cctctagggt gtcgttaatt acccgtacta aaggtttgga aaagaaaaaa      600

gagaccgcct cgtttctttt tcttcgtcga aaaaggcaat aaaaattttt atcacgtttc      660

tttttcttga aatttttttt tttagttttt ttctctttca gtgacctcca ttgatattta      720

agttaataaa cggtcttcaa tttctcaagt ttcagtttca tttttcttgt tctattacaa      780

ctttttttac ttcttgttca ttagaaagaa agcatagcaa tctaatctaa ggggcggtgt      840

tgacaattaa tcatcggcat agtatatcgg catagtataa tacgacaagg tgaggaacta      900

aaccatggcc aagttgacca gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc      960

ggtcgagttc tggaccgacc ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc     1020

cggtgtggtc cgggacgacg tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc     1080

ggacaacacc ctggcctggg tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc     1140

ggaggtcgtg tccacgaact tccgggacgc ctccgggccg gccatgaccg agatcggcga     1200

gcagccgtgg gggcgggagt tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt     1260

ggccgaggag caggactgac acgtccgacg gcggcccacg ggtcccaggc ctcggagatc     1320

cgtccccctt ttcctttgtc gatatcatgt aattagttat gtcacgctta cattcacgcc     1380

ctccccccac atccgctcta accgaaaagg aaggagttag acaacctgaa gtctaggtcc     1440

ctatttattt ttttatagtt atgttagtat taagaacgtt atttatattt caaatttttc     1500

ttttttttct gtacagacgc gtgtacgcat gtaacattat actgaaaacc ttgcttgaga     1560

aggttttggg acgctcgaag gctttaattt gcaagctgga gaccaacatg tgagcaaaag     1620

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     1680

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     1740

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     1800

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     1860

aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     1920

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     1980

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     2040

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     2100

ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     2160

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca     2220

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg     2280

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agatcagatc     2340

taacatccaa agacgaaagg ttgaatgaaa cctttttgcc atccgacatc cacaggtcca     2400

ttctcacaca taagtgccaa acgcaacagg aggggataca ctagcagcag accgttgcaa     2460

acgcaggacc tccactcctc ttctcctcaa cacccacttt tgccatcgaa aaaccagccc     2520

agttattggg cttgattgga gctcgctcat tccaattcct tctattaggc tactaacacc     2580

atgactttat tagcctgtct atcctggccc ccctggcgag gttcatgttt gtttatttcc     2640

gaatgcaaca agctccgcat tacacccgaa catcactcca gatgagggct ttctgagtgt     2700

ggggtcaaat agtttcatgt tccccaaatg gcccaaaact gacagtttaa acgctgtctt     2760

ggaacctaat atgacaaaag cgtgatctca tccaagatga actaagtttg gttcgttgaa     2820

atgctaacgg ccagttggtc aaaaagaaac ttccaaaagt cggcataccg tttgtcttgt     2880

ttggtattga ttgacgaatg ctcaaaaata atctcattaa tgcttagcgc agtctctcta     2940

tcgcttctga accccggtgc acctgtgccg aaacgcaaat ggggaaacac ccgctttttg     3000

gatgattatg cattgtctcc acattgtatg cttccaagat tctggtggga atactgctga     3060

tagcctaacg ttcatgatca aaatttaact gttctaaccc ctacttgaca gcaatatata     3120

aacagaagga agctgccctg tcttaaacct ttttttttat catcattatt agcttacttt     3180

cataattgcg actggttcca attgacaagc ttttgatttt aacgactttt aacgacaact     3240

tgagaagatc aaaaaacaac taattattcg aaacgatgag atttccttca atttttactg     3300

ctgttttatt cgcagcatcc tccgcattag ctgctccagt caacactaca acagaagatg     3360

aaacggcaca aattccggct gaagctgtca tcggttactc agatttagaa ggggatttcg     3420

atgttgctgt tttgccattt tccaacagca caaataacgg gttattgttt ataaatacta     3480

ctattgccag cattgctgct aaagaagaag gggtatctct cgagaaaaga gaggctgaag     3540

ctagcgtcgc cagaaaggat tgggagagtc ctacctattc gtggctttac caatttcctc     3600

tgcctattcc tccggtcaag acgcccaaac tgaccgttac caacctggtg actggcaacc     3660

ccattcacta ttacgaggtc tacatcaacc ggttcaccca acaagtgtat ccaaacaagg     3720

gtcccgcaac tcttgttggt tacgacggca tctctcccgg cccgaccttt atcgtggaga     3780

gaggtcatga ggctgttgtg cgcttcgtca acaatgccag catcgaaaac tcggtccatc     3840

tccacgggtc atactctcgc gctccttggg atggttgggc agaggatgtg accatgccag     3900

gcgagttcaa ggactactac tatcccaacc aacaggcggc ccgtttcctg tggtaccacg     3960

atcacgcatt catgcatact gctgagaatg catattttgg ccaagctggg gcctacatta     4020

ttcatgatcc tgctgaagac gccttgaacc ttccctcagg ttacggtgtt catgatattc     4080

ctctggtgct ctcttccaag cagtacaaca acaatggcag tctgttcacc accaatggtg     4140

agacggactc gctctttggc gatgttatcc acgtcaacgg ccagccctgg ccctacttca     4200

acgttgagcc tcgcaagtac cgcctccgct tcctcgacgc tgccgtctca cgcaccttca     4260

agctctactt ccagcgtcaa actggcagct cagccaagat tcctttccaa gtcattgcca     4320

cagatgccgg cttgatggcc tcaccagcca ccacaaacga cctttacatc agcatgggag     4380

agcggtacga ggttgtcttt gacttttcgc cctttgctgg ccaaaacatc accttgcgca     4440

acacggacga cgtgggccag gacgacgatt acctccacac caacaaggtc atgagattca     4500

tcgttggcaa caccccagtg accgacacca gctccattcc cagcactctg gctactgtcg     4560

actggccgac ctctgatgga accggtgtgg acagacactt taagtttgac cgctccaatg     4620

gcgagtggca gatcaacgga gtcgtctttg ccgatgtcaa caaccgtgtg cttgccaatg     4680

tcccccgcgg caaggttgaa atttgggagc tcgagaacgg cggcggcgga tggagccacc     4740

caatccacat tcacctggtc gacttcaaag tcttgtggcg ctcgaatgac gatggcagac     4800

cggtctacaa ctacgaggcc cagggtttga aggatgttgt ctggcttgcg cccaacgaga     4860

ttgtcagagt ggaggcccac tacgccccat gggacggagt ctacatgttc cactgccaca     4920

acctgattca cgaggatcac gacatgatgg ctgccttcaa cgtcactgct ctgactgact     4980

tgggatacaa cgagaccgcg ttccgtgacc ccatggaggc cagatggaga gccgagccgg     5040

tcacggctgc caagttcacc acggctgcca tcaccgaaaa gattcagttc atggccggac     5100

tgcagcccta caacaatgtc gaggaagtct tggaggttct cgacgagtac tgggccacgc     5160

acagcaagcg tgacgcccaa gaccctgctc ccaagaccag aagaatgaga attgagggcg     5220

ggaaggtcaa agaggtccgg tgagc                                           5245


