                         SEQUENCE LISTING

<110>  Himmler, Gottfried
 
<120>  SECRETORY IMMUNOGLOBULIN DEFICIENCY TREATMENT AND PROPHYLAXIS

<130>  HI002P

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptid


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid but proline

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid but proline

<400>  1

Asn Xaa Thr Xaa 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptid


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid but proline

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid but proline

<400>  2

Asn Xaa Ser Xaa 
1               


<210>  3
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain antibody sequence

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Ser Pro Thr Ser Pro Lys Val Phe Pro 
        115                 120                 125             


Leu Ser Leu Cys Ser Thr Gln Pro Asp Gly Asn Val Val Ile Ala Cys 
    130                 135                 140                 


Leu Val Gln Gly Phe Phe Pro Gln Glu Pro Leu Ser Val Thr Trp Ser 
145                 150                 155                 160 


Glu Ser Gly Gln Gly Val Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp 
                165                 170                 175     


Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala 
            180                 185                 190         


Thr Gln Cys Leu Ala Gly Lys Ser Val Thr Cys His Val Lys His Tyr 
        195                 200                 205             


Thr Asn Pro Ser Gln Asp Val Thr Val Pro Cys Pro Val Pro Ser Thr 
    210                 215                 220                 


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys 
225                 230                 235                 240 


Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu 
                245                 250                 255     


Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp 
            260                 265                 270         


Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala 
        275                 280                 285             


Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser 
    290                 295                 300                 


Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr Phe 
305                 310                 315                 320 


Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr 
                325                 330                 335     


Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro 
            340                 345                 350         


Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys 
        355                 360                 365             


Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln 
    370                 375                 380                 


Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg 
385                 390                 395                 400 


Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu 
                405                 410                 415     


Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met 
            420                 425                 430         


Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp 
        435                 440                 445             


Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala 
    450                 455                 460                 


Glu Val Asp Gly Thr Cys Tyr 
465                 470     


<210>  4
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain antibody sequence

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Ser Pro Thr Ser Pro Lys Val Phe Pro 
        115                 120                 125             


Leu Ser Leu Asp Ser Thr Pro Gln Asp Gly Asn Val Val Val Ala Cys 
    130                 135                 140                 


Leu Val Gln Gly Phe Phe Pro Gln Glu Pro Leu Ser Val Thr Trp Ser 
145                 150                 155                 160 


Glu Ser Gly Gln Asn Val Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp 
                165                 170                 175     


Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala 
            180                 185                 190         


Thr Gln Cys Pro Asp Gly Lys Ser Val Thr Cys His Val Lys His Tyr 
        195                 200                 205             


Thr Asn Pro Ser Gln Asp Val Thr Val Pro Cys Pro Val Pro Pro Pro 
    210                 215                 220                 


Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly 
                245                 250                 255     


Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly 
            260                 265                 270         


Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr 
        275                 280                 285             


Ser Val Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly 
    290                 295                 300                 


Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu 
305                 310                 315                 320 


Thr Ala Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His 
                325                 330                 335     


Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr 
            340                 345                 350         


Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg 
        355                 360                 365             


Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp 
    370                 375                 380                 


Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr 
385                 390                 395                 400 


Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe 
                405                 410                 415     


Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys 
            420                 425                 430         


Thr Ile Asp Arg Met Ala Gly Lys Pro Thr His Val Asn Val Ser Val 
        435                 440                 445             


Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
    450                 455             


<210>  5
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain antibody sequence

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Tyr Leu His Gly Asp Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Ala Arg Tyr 
                405                 410                 415     


Ser Pro Arg Met Leu Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  6
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain antibody sequence

<400>  6

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


