                         SEQUENCE LISTING

<110>  Affiris AG
 
<120>  Vaccine

<130>  R 63718

<150>  EP 12169088.7  
<151>  2012-05-23

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  1

Ile Ser His Lys Asp Met Gln Leu Gly Arg 
1               5                   10  


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  2

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  3

Lys Asp Met Gln Leu Gly Arg 
1               5           


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  4

Val Val Ala Ser Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln 
1               5                   10                  15      


Leu Gly Arg 
            


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  5

Ala Ser His Lys Asp Met Gln Leu Gly Arg 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  6

Ile Ala His Lys Asp Met Gln Leu Gly Arg 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  7

Ile Ser Ala Lys Asp Met Gln Leu Gly Arg 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  8

Ile Ser His Ala Asp Met Gln Leu Gly Arg 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  9

Ile Ser His Lys Ala Met Gln Leu Gly Arg 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  10

Ile Ser His Lys Asp Ala Gln Leu Gly Arg 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  11

Ile Ser His Lys Asp Met Ala Leu Gly Arg 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  12

Ile Ser His Lys Asp Met Gln Ala Gly Arg 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  13

Ile Ser His Lys Asp Met Gln Leu Ala Arg 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  14

Ile Ser His Lys Asp Met Gln Leu Gly Ala 
1               5                   10  


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  15

Ala Ala Ile Ser His Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  16

Ala Asn Ala Ser His Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  17

Ala Asn Ile Ser Ala Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  18

Ala Asn Ile Ser His Lys Asp Ala Gln Leu Gly Arg 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  19

Ala Asn Ile Ser His Lys Asp Met Gln Ala Gly Arg 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  20

Ala Asn Ile Ser His Lys Asp Met Gln Leu Ala Arg 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  21

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Ala 
1               5                   10          


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  22

Lys Asp Met Gln Leu Gly Ala 
1               5           


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  23

Val Val Ala Ser Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln 
1               5                   10                  15      


Leu Gly Ala 
            


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  24

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Thr 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  25

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Gln 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  26

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Tyr 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  27

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Met 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  28

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Gly 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  29

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Val 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  30

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Lys 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  31

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Ser 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  32

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly His 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  33

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Asn 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  34

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Leu 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  35

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Trp 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  36

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Phe 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  37

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Pro 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  38

Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Asp 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  39

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  40

Ala Asn Ile Ser Gln Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  41

Ala Asn Ile Ser Glu Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  42

Ala Asn Ile Ser Ser Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  43

Ala Asn Ile Ser Lys Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  44

Ala Asn Ile Ser Asn Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  45

Ala Asn Ile Ser Ile Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  46

Ala Asn Ile Ser Arg Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  47

Ala Asn Ile Ser Met Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  48

Ala Asn Ile Ser Val Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  49

Ala Asn Ile Ser Tyr Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  50

Ala Asn Ile Ser Leu Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  51

Ala Asn Ile Ser Trp Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  52

Ala Asn Ile Ser Gly Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  53

Ala Asn Ile Ser Pro Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  54

Ala Asn Ile Ser Phe Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  55

Ala Asn Ile Ser Asp Lys Asp Met Gln Leu Gly Arg 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  56

Ala Asn Ile Ser His Lys Asp Val Gln Leu Gly Arg 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  57

Ala Asn Ile Ser His Lys Asp Thr Gln Leu Gly Arg 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  58

Ala Asn Ile Ser His Lys Asp Tyr Gln Leu Gly Arg 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  59

Ala Asn Ile Ser His Lys Asp Leu Gln Leu Gly Arg 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  60

Ala Asn Ile Ser His Lys Asp Lys Gln Leu Gly Arg 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  61

Ala Asn Ile Ser His Lys Asp His Gln Leu Gly Arg 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  62

Ala Asn Ile Ser His Lys Asp Arg Gln Leu Gly Arg 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  63

Ala Asn Ile Ser His Lys Asp Trp Gln Leu Gly Arg 
1               5                   10          


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  64

Ala Asn Ile Ser His Lys Asp Ser Gln Leu Gly Arg 
1               5                   10          


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  65

Ala Asn Ile Ser His Lys Asp Phe Gln Leu Gly Arg 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  66

Ala Asn Ile Ser His Lys Asp Asn Gln Leu Gly Arg 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  67

Ala Asn Ile Ser His Lys Asp Pro Gln Leu Gly Arg 
1               5                   10          


<210>  68
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  68

Ala Asn Ile Ser His Lys Asp Gly Gln Leu Gly Arg 
1               5                   10          


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  69

Ala Asn Ile Ser His Lys Asp Asp Gln Leu Gly Arg 
1               5                   10          


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  70

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly Ala 
1               5                   10          


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  71

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly Gln 
1               5                   10          


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  72

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly Ser 
1               5                   10          


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  73

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly Met 
1               5                   10          


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  74

Ala Asn Ile Ser Met Lys Asp Met Gln Leu Gly Asn 
1               5                   10          


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  75

Ala Asn Ile Ser Thr Lys Asp Lys Gln Leu Gly Met 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  76

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly His 
1               5                   10          


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  77

Ala Asn Ile Ser Ala Lys Asp Met Gln Leu Gly Ala 
1               5                   10          


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  78

Ala Asn Ile Ser Met Lys Asp Met Gln Leu Gly Ala 
1               5                   10          


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  79

Ala Asn Ile Ser Thr Lys Asp Lys Gln Leu Gly Ala 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  80

Ala Asn Ile Ser Thr Lys Asp Ala Gln Leu Gly Ala 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  81

Ala Asn Ile Ser Met Lys Asp Met Gln Leu Gly Ser 
1               5                   10          


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  82

Ala Asn Ile Ser Thr Lys Asp Val Gln Leu Gly Ala 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  83

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly Asn 
1               5                   10          


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  84

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly Lys 
1               5                   10          


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  85

Ala Asn Ile Ser Met Lys Asp Met Gln Leu Gly Met 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  86

Ala Asn Ile Ser Thr Lys Asp Met Gln Leu Gly Thr 
1               5                   10          


<210>  87
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  87

Ala Asn Ile Ser His Lys Asp Lys Gln Leu Gly Lys 
1               5                   10          


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  88

Ala Asn Ile Ser Met Lys Asp Met Gln Leu Gly His 
1               5                   10          


<210>  89
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  89

Ala Asn Ile Ser Ala Lys Asp Ala Gln Leu Gly Ala 
1               5                   10          


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  90

Ala Asn Ile Ser Met Lys Asp Lys Gln Leu Gly Lys 
1               5                   10          


<210>  91
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  91

Ala Asn Ile Ser His Lys Asp Ser Gln Leu Gly Lys 
1               5                   10          


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  92

Ala Asn Ile Ser Met Lys Asp Met Gln Leu Gly Phe 
1               5                   10          


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  93

Ala Asn Ile Ser Ile Lys Asp Met Gln Leu Gly Ala 
1               5                   10          


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  94

Ala Asn Ile Ser Met Lys Asp Met Gln Leu Gly Lys 
1               5                   10          


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  95

Ala Asn Ile Ser Leu Lys Asp Met Gln Leu Gly Ala 
1               5                   10          


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  96

Ala Asn Ile Ser His Lys Asp Lys Gln Leu Gly Phe 
1               5                   10          


<210>  97
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  97

Ala Asn Ile Ser Met Lys Asp Lys Gln Leu Gly Phe 
1               5                   10          


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope

<400>  98

Ala Asn Ile Ser Ile Lys Asp Met Gln Leu Gly Lys 
1               5                   10          


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = SEQ ID No. 100 or an N-terminal truncated fragment thereof 
       consisting of 1 to 6 amino acid residues

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, serine, threonine, tyrosine and 
       valine

<400>  99

Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5               


<210>  100
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = VVASQLR (SEQ ID No. 101) or an N-terminal truncated fragment 
       thereof consisting of 1 to 6 amino acid residues

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<400>  100

Xaa Ala Asn Ile Ser Xaa 
1               5       


<210>  101
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  101

Val Val Ala Ser Gln Leu Arg 
1               5           


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<400>  102

Ala Asn Ile Ser Xaa 
1               5   


<210>  103
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<400>  103

Asn Ile Ser Xaa 
1               


<210>  104
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, iso-leucine, 
       leucine, lysine, methionine, serine, threonine, tyro-sine and 
       valine

<400>  104

Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5                   10          


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, iso-leucine, 
       leucine, lysine, methionine, serine, threonine, tyro-sine and 
       valine

<400>  105

Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5                   10      


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, iso-leucine, 
       leucine, lysine, methionine, serine, threonine, tyro-sine and 
       valine

<400>  106

Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5                   10  


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, iso-leucine, 
       leucine, lysine, methionine, serine, threonine, tyro-sine and 
       valine

<400>  107

Ser Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5                   


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, iso-leucine, 
       leucine, lysine, methionine, serine, threonine, tyro-sine and 
       valine

<400>  108

Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5               


<210>  109
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  109

Val Ala Ser Gln Leu Arg 
1               5       


<210>  110
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  110

Ala Ser Gln Leu Arg 
1               5   


<210>  111
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  111

Ser Gln Leu Arg 
1               


<210>  112
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, serine, threonine, tyrosine and 
       valine

<400>  112

Val Val Ala Ser Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln 
1               5                   10                  15      


Leu Gly Xaa 
            


<210>  113
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, iso-leucine, 
       leucine, lysine, methionine, serine, threonine, tyro-sine and 
       valine

<400>  113

Val Ala Ser Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu 
1               5                   10                  15      


Gly Xaa 
        


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, iso-leucine, 
       leucine, lysine, methionine, serine, threonine, tyro-sine and 
       valine

<400>  114

Ala Ser Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly 
1               5                   10                  15      


Xaa 
    


<210>  115
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, serine, threonine, tyrosine and 
       valine

<400>  115

Ser Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5                   10                  15      


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, serine, threonine, tyrosine and 
       valine

<400>  116

Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5                   10                  15  


<210>  117
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, iso-leucine, 
       leucine, lysine, methionine, serine, threonine, tyro-sine and 
       valine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, serine, threonine, tyrosine and 
       valine

<400>  117

Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5                   10                  


<210>  118
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, serine, threonine, tyrosine and 
       valine

<400>  118

Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Xaa 
1               5                   10              


<210>  119
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  119

Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5                   10          


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  120

Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5                   10      


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  121

Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5                   10  


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  122

Ser Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5                   


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  123

Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5               


<210>  124
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  124

Val Val Ala Ser Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln 
1               5                   10                  15      


Leu Gly Arg 
            


<210>  125
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  125

Val Ala Ser Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu 
1               5                   10                  15      


Gly Arg 
        


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  126

Ala Ser Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly 
1               5                   10                  15      


Arg 
    


<210>  127
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  127

Ser Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5                   10                  15      


<210>  128
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  128

Gln Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5                   10                  15  


<210>  129
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  129

Leu Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5                   10                  


<210>  130
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variotope


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, asparagine, glutamine, glutamic acid, histidine, 
       arginine, isoleucine, lysine, methionine, serine and threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = an amino acid residue selected from the group consisting of 
       alanine, arginine, histidine, isoleucine, leucine, lysine, 
       methionine, threonine, tyrosine and valine

<400>  130

Arg Ala Asn Ile Ser Xaa Lys Asp Xaa Gln Leu Gly Arg 
1               5                   10              


