               SEQUENCE LISTING

<110> Chr. Hansen A/S

<120> Variants of chymosin with improved milk-clotting properties

<130> P4629PC00

<160> 2

<170> BiSSAP 1.0

<210> 1
<211> 381
<212> PRT
<213> Bos taurus

<220> 
<221> SOURCE
<222> 1..381
<223> /mol_type="protein"
      /organism="Bos taurus"

<400> 1
Met Arg Cys Leu Val Val Leu Leu Ala Val Phe Ala Leu Ser Gln Gly 
1               5                   10                   15    
Ala Glu Ile Thr Arg Ile Pro Leu Tyr Lys Gly Lys Ser Leu Arg Lys 
            20                   25                  30        
Ala Leu Lys Glu His Gly Leu Leu Glu Asp Phe Leu Gln Lys Gln Gln 
        35                   40                  45            
Tyr Gly Ile Ser Ser Lys Tyr Ser Gly Phe Gly Glu Val Ala Ser Val 
    50                   55                  60                
Pro Leu Thr Asn Tyr Leu Asp Ser Gln Tyr Phe Gly Lys Ile Tyr Leu 
65                   70                  75                  80
Gly Thr Pro Pro Gln Glu Phe Thr Val Leu Phe Asp Thr Gly Ser Ser 
                85                   90                  95    
Asp Phe Trp Val Pro Ser Ile Tyr Cys Lys Ser Asn Ala Cys Lys Asn 
            100                  105                110        
His Gln Arg Phe Asp Pro Arg Lys Ser Ser Thr Phe Gln Asn Leu Gly 
        115                  120                125            
Lys Pro Leu Ser Ile His Tyr Gly Thr Gly Ser Met Gln Gly Ile Leu 
    130                  135                140                
Gly Tyr Asp Thr Val Thr Val Ser Asn Ile Val Asp Ile Gln Gln Thr 
145                  150                155                  160
Val Gly Leu Ser Thr Gln Glu Pro Gly Asp Val Phe Thr Tyr Ala Glu 
                165                  170                175    
Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Ser Leu Ala Ser Glu Tyr 
            180                  185                190        
Ser Ile Pro Val Phe Asp Asn Met Met Asn Arg His Leu Val Ala Gln 
        195                  200                205            
Asp Leu Phe Ser Val Tyr Met Asp Arg Asn Gly Gln Glu Ser Met Leu 
    210                  215                220                
Thr Leu Gly Ala Ile Asp Pro Ser Tyr Tyr Thr Gly Ser Leu His Trp 
225                  230                235                  240
Val Pro Val Thr Val Gln Gln Tyr Trp Gln Phe Thr Val Asp Ser Val 
                245                  250                255    
Thr Ile Ser Gly Val Val Val Ala Cys Glu Gly Gly Cys Gln Ala Ile 
            260                  265                270        
Leu Asp Thr Gly Thr Ser Lys Leu Val Gly Pro Ser Ser Asp Ile Leu 
        275                  280                285            
Asn Ile Gln Gln Ala Ile Gly Ala Thr Gln Asn Gln Tyr Gly Glu Phe 
    290                  295                300                
Asp Ile Asp Cys Asp Asn Leu Ser Tyr Met Pro Thr Val Val Phe Glu 
305                  310                315                  320
Ile Asn Gly Lys Met Tyr Pro Leu Thr Pro Ser Ala Tyr Thr Ser Gln 
                325                  330                335    
Asp Gln Gly Phe Cys Thr Ser Gly Phe Gln Ser Glu Asn His Ser Gln 
            340                  345                350        
Lys Trp Ile Leu Gly Asp Val Phe Ile Arg Glu Tyr Tyr Ser Val Phe 
        355                  360                365            
Asp Arg Ala Asn Asn Leu Val Gly Leu Ala Lys Ala Ile 
    370                  375                380    

<210> 2
<211> 381
<212> PRT
<213> Camelus dromedarius

<220> 
<221> SOURCE
<222> 1..381
<223> /mol_type="protein"
      /organism="Camelus dromedarius"

<400> 2
Met Arg Cys Leu Val Val Leu Leu Ala Ala Leu Ala Leu Ser Gln Ala 
1               5                   10                   15    
Ser Gly Ile Thr Arg Ile Pro Leu His Lys Gly Lys Thr Leu Arg Lys 
            20                   25                  30        
Ala Leu Lys Glu Arg Gly Leu Leu Glu Asp Phe Leu Gln Arg Gln Gln 
        35                   40                  45            
Tyr Ala Val Ser Ser Lys Tyr Ser Ser Leu Gly Lys Val Ala Arg Glu 
    50                   55                  60                
Pro Leu Thr Ser Tyr Leu Asp Ser Gln Tyr Phe Gly Lys Ile Tyr Ile 
65                   70                  75                  80
Gly Thr Pro Pro Gln Glu Phe Thr Val Val Phe Asp Thr Gly Ser Ser 
                85                   90                  95    
Asp Leu Trp Val Pro Ser Ile Tyr Cys Lys Ser Asn Val Cys Lys Asn 
            100                  105                110        
His His Arg Phe Asp Pro Arg Lys Ser Ser Thr Phe Arg Asn Leu Gly 
        115                  120                125            
Lys Pro Leu Ser Ile His Tyr Gly Thr Gly Ser Met Glu Gly Phe Leu 
    130                  135                140                
Gly Tyr Asp Thr Val Thr Val Ser Asn Ile Val Asp Pro Asn Gln Thr 
145                  150                155                  160
Val Gly Leu Ser Thr Glu Gln Pro Gly Glu Val Phe Thr Tyr Ser Glu 
                165                  170                175    
Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro Ser Leu Ala Ser Glu Tyr 
            180                  185                190        
Ser Val Pro Val Phe Asp Asn Met Met Asp Arg His Leu Val Ala Arg 
        195                  200                205            
Asp Leu Phe Ser Val Tyr Met Asp Arg Asn Gly Gln Gly Ser Met Leu 
    210                  215                220                
Thr Leu Gly Ala Ile Asp Pro Ser Tyr Tyr Thr Gly Ser Leu His Trp 
225                  230                235                  240
Val Pro Val Thr Leu Gln Gln Tyr Trp Gln Phe Thr Val Asp Ser Val 
                245                  250                255    
Thr Ile Asn Gly Val Ala Val Ala Cys Val Gly Gly Cys Gln Ala Ile 
            260                  265                270        
Leu Asp Thr Gly Thr Ser Val Leu Phe Gly Pro Ser Ser Asp Ile Leu 
        275                  280                285            
Lys Ile Gln Met Ala Ile Gly Ala Thr Glu Asn Arg Tyr Gly Glu Phe 
    290                  295                300                
Asp Val Asn Cys Gly Asn Leu Arg Ser Met Pro Thr Val Val Phe Glu 
305                  310                315                  320
Ile Asn Gly Arg Asp Tyr Pro Leu Ser Pro Ser Ala Tyr Thr Ser Lys 
                325                  330                335    
Asp Gln Gly Phe Cys Thr Ser Gly Phe Gln Gly Asp Asn Asn Ser Glu 
            340                  345                350        
Leu Trp Ile Leu Gly Asp Val Phe Ile Arg Glu Tyr Tyr Ser Val Phe 
        355                  360                365            
Asp Arg Ala Asn Asn Arg Val Gly Leu Ala Lys Ala Ile 
    370                  375                380    

