                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Texas System
       Sousa, Rui
       Rana, Mitra
 
<120>  GTP Sensors

<130>  STTM0005WO

<150>  US 61/648,998
<151>  2012-05-18

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  1

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Arg Phe Ser Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Ser Gly Glu Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Asp Asp Gly Ser Tyr Arg Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Met Asn Ala Trp Asp Ala Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Glu His Asn Val Lys Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp Ala Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Ser Val Leu Leu Pro Asp Asn His Tyr Leu Ser Phe Gln Ser Lys Leu 
        195                 200                 205             


Phe Lys Asp Pro Asn Glu Gln Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Pro Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Gly Ala Gly Ser Gly Ser Gly Gly Lys Lys Leu Thr Ile Gly Leu Ile 
                245                 250                 255     


Gly Asn Pro Asn Ser Gly Lys Thr Thr Leu Phe Asn Gln Leu Thr Gly 
            260                 265                 270         


Ser Arg Gln Arg Val Gly Asn Trp Ala Gly Val Thr Val Tyr Asn Ser 
        275                 280                 285             


Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
    290                 295                 300                 


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala 
305                 310                 315                 320 


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
                325                 330                 335     


Pro Asp Asn His Tyr Leu Ser Phe Gln Ser Lys Leu Ser Lys Asp Pro 
            340                 345                 350         


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
        355                 360                 365             


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly 
    370                 375                 380                 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
385                 390                 395                 400 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
                405                 410                 415     


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile 
            420                 425                 430         


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
        435                 440                 445             


Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
    450                 455                 460                 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
465                 470                 475                 480 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
                485                 490                 495     


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
            500                 505                 510         


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
        515                 520                 525             


Asn Gly Thr Glu Arg Lys Glu Gly Gln Phe Ser Thr Thr Asp His Gln 
    530                 535                 540                 


Val Thr Leu Val Asp Leu Pro Gly Thr Tyr Ser Leu Thr Thr Ile Ser 
545                 550                 555                 560 


Ser Gln Thr Ser Leu Asp Glu Gln Ile Ala Cys His Tyr Ile Leu Ser 
                565                 570                 575     


Gly Asp Ala Asp Leu Leu Ile Asn Val Val Asp Ala Ser Asn Leu Glu 
            580                 585                 590         


Arg Asn Leu Tyr Leu Thr Leu Gln Leu Leu Glu Leu Gly Ile Pro Cys 
        595                 600                 605             


Ile Val Ala Leu Asn Met Leu Asp Ile Ala Glu Lys Gln Asn Ile Arg 
    610                 615                 620                 


Ile Glu Ile Asp Ala Leu Ser Ala Arg Leu Gly Cys Pro Val Ile Pro 
625                 630                 635                 640 


Leu Val Ser Thr Arg Gly Arg Gly Ile Glu Ala Leu Lys Leu Ala Ile 
                645                 650                 655     


Asp Arg Tyr Lys Ala Asn Glu Asn Val Glu Leu Val His Tyr Ala Gln 
            660                 665                 670         


Pro Leu Leu Asn Glu Ala Asp Ser Leu Ala Lys Val Met Pro Ser Asp 
        675                 680                 685             


Ile Pro Leu Lys Gln Arg Arg Trp Leu Gly Leu Gln Met Leu Glu Gly 
    690                 695                 700                 


Asp Ile Tyr Ser Arg Ala Tyr Ala Gly Glu Ala Ser Gln His Leu Asp 
705                 710                 715                 720 


Ala Ala Leu Ala Arg Leu Arg Asn Glu Met Asp Asp Pro Ala Leu His 
                725                 730                 735     


Ile Ala Asp Ala Arg Tyr Gln Cys Ile Ala Ala Ile Cys Asp Val Val 
            740                 745                 750         


Ser 
    


<210>  2
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  2

Gly Gly Ala Gly Ser Gly Ser Gly Gly Lys Lys Leu Thr Ile Gly Leu 
1               5                   10                  15      


Ile Gly Asn Pro Asn Ser Gly Lys Thr Thr Leu Phe Asn Gln Leu Thr 
            20                  25                  30          


Gly Ser Arg Gln Arg Val Gly Asn Trp Ala Gly Val Thr Val Tyr Asn 
        35                  40                  45              


Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys 
    50                  55                  60                  


Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu 
65                  70                  75                  80  


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
                85                  90                  95      


Leu Pro Asp Asn His Tyr Leu Ser Phe Gln Ser Lys Leu Ser Lys Asp 
            100                 105                 110         


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
        115                 120                 125             


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly 
    130                 135                 140                 


Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
145                 150                 155                 160 


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
                165                 170                 175     


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu 
            180                 185                 190         


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
        195                 200                 205             


Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met 
    210                 215                 220                 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
225                 230                 235                 240 


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
                245                 250                 255     


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
            260                 265                 270         


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
        275                 280                 285             


Tyr Asn Gly Thr Glu Arg Lys Glu Gly Gln Phe Ser Thr Thr Asp His 
    290                 295                 300                 


Gln Val Thr Leu Val Asp Leu Pro Gly Thr Tyr Ser Leu Thr Thr Ile 
305                 310                 315                 320 


Ser Ser Gln Thr Ser Leu Asp Glu Gln Ile Ala Cys His Tyr Ile Leu 
                325                 330                 335     


Ser Gly Asp Ala Asp Leu Leu Ile Asn Val Val Asp Ala Ser Asn Leu 
            340                 345                 350         


Glu Arg Asn Leu Tyr Leu Thr Leu Gln Leu Leu Glu Leu Gly Ile Pro 
        355                 360                 365             


Cys Ile Val Ala Leu Asn Met Leu Asp Ile Ala Glu Lys Gln Asn Ile 
    370                 375                 380                 


Arg Ile Glu Ile Asp Ala Leu Ser Ala Arg Leu Gly Cys Pro Val Ile 
385                 390                 395                 400 


Pro Leu Val Ser Thr Arg Gly Arg Gly Ile Glu Ala Leu Lys Leu Ala 
                405                 410                 415     


Ile Asp Arg Tyr Lys Ala Asn Glu Asn Val Glu Leu Val His Tyr Ala 
            420                 425                 430         


Gln Pro Leu Leu Asn Glu Ala Asp Ser Leu Ala Lys Val Met Pro Ser 
        435                 440                 445             


Asp Ile Pro Leu Lys Gln Arg Arg Trp Leu Gly Leu Gln Met Leu Glu 
    450                 455                 460                 


Gly Asp Ile Tyr Ser Arg Ala Tyr Ala Gly Glu Ala Ser Gln His Leu 
465                 470                 475                 480 


Asp Ala Ala Leu Ala Arg Leu Arg Asn Glu Met Asp Asp Pro Ala Leu 
                485                 490                 495     


His Ile Ala Asp Ala Arg Tyr Gln Cys Ile Ala Ala Ile Cys Asp Val 
            500                 505                 510         


Val Ser 
        


<210>  3
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  3

Met Lys Lys Leu Thr Ile Gly Leu Ile Gly Asn Pro Asn Ser Gly Lys 
1               5                   10                  15      


Thr Thr Leu Phe Asn Gln Leu Thr Gly Ser Arg Gln Arg Val Gly Asn 
            20                  25                  30          


Trp Ala Gly Val Thr Val Glu Arg Lys Glu Gly Gln Phe Ser Thr Thr 
        35                  40                  45              


Asp His Gln Val Thr Leu Val Asp Leu Pro Gly Thr Tyr Ser Leu Thr 
    50                  55                  60                  


Thr Ile Ser Ser Gln Thr Ser Leu Asp Glu Gln Ile Ala Cys His Tyr 
65                  70                  75                  80  


Ile Leu Ser Gly Asp Ala Asp Leu Leu Ile Asn Val Val Asp Ala Ser 
                85                  90                  95      


Asn Leu Glu Arg Asn Leu Tyr Leu Thr Leu Gln Leu Leu Glu Leu Gly 
            100                 105                 110         


Ile Pro Cys Ile Val Ala Leu Asn Met Leu Asp Ile Ala Glu Lys Gln 
        115                 120                 125             


Asn Ile Arg Ile Glu Ile Asp Ala Leu Ser Ala Arg Leu Gly Cys Pro 
    130                 135                 140                 


Val Ile Pro Leu Val Ser Thr Arg Gly Arg Gly Ile Glu Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Ile Asp Arg Tyr Lys Ala Asn Glu Asn Val Glu Leu Val His 
                165                 170                 175     


Tyr Ala Gln Pro Leu Leu Asn Glu Ala Asp Ser Leu Ala Lys Val Met 
            180                 185                 190         


Pro Ser Asp Ile Pro Leu Lys Gln Arg Arg Trp Leu Gly Leu Gln Met 
        195                 200                 205             


Leu Glu Gly Asp Ile Tyr Ser Arg Ala Tyr Ala Gly Glu Ala Ser Gln 
    210                 215                 220                 


His Leu Asp Ala Ala Leu Ala Arg Leu Arg Asn Glu Met Asp Asp Pro 
225                 230                 235                 240 


Ala Leu His Ile Ala Asp Ala Arg Tyr Gln Cys Ile Ala Ala Ile Cys 
                245                 250                 255     


Asp Val Val Ser 
            260 


<210>  4
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  4

Tyr Asn Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
1               5                   10                  15      


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val 
            20                  25                  30          


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
        35                  40                  45              


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Phe Gln Ser Lys Leu Ser 
    50                  55                  60                  


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
65                  70                  75                  80  


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly 
                85                  90                  95      


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
            100                 105                 110         


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
        115                 120                 125             


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
    130                 135                 140                 


Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
145                 150                 155                 160 


Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp 
                165                 170                 175     


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
            180                 185                 190         


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
        195                 200                 205             


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
    210                 215                 220                 


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
225                 230                 235                 240 


Leu Glu Tyr Asn 
                


<210>  5
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  5

Gly Thr Glu Arg Lys Glu Gly Gln Phe Ser Thr Thr Asp His Gln Val 
1               5                   10                  15      


Thr Leu Val Asp Leu Pro Gly Thr Tyr Ser Leu Thr Thr Ile Ser Ser 
            20                  25                  30          


Gln Thr Ser Leu Asp Glu Gln Ile Ala Cys His Tyr Ile Leu Ser Gly 
        35                  40                  45              


Asp Ala Asp Leu Leu Ile Asn Val Val Asp Ala Ser Asn Leu Glu Arg 
    50                  55                  60                  


Asn Leu Tyr Leu Thr Leu Gln Leu Leu Glu Leu Gly Ile Pro Cys Ile 
65                  70                  75                  80  


Val Ala Leu Asn Met Leu Asp Ile Ala Glu Lys Gln Asn Ile Arg Ile 
                85                  90                  95      


Glu Ile Asp Ala Leu Ser Ala Arg Leu Gly Cys Pro Val Ile Pro Leu 
            100                 105                 110         


Val Ser Thr Arg Gly Arg Gly Ile Glu Ala Leu Lys Leu Ala Ile Asp 
        115                 120                 125             


Arg Tyr Lys Ala Asn Glu Asn Val Glu Leu Val His Tyr Ala Gln Pro 
    130                 135                 140                 


Leu Leu Asn Glu Ala Asp Ser Leu Ala Lys Val Met Pro Ser Asp Ile 
145                 150                 155                 160 


Pro Leu Lys Gln Arg Arg Trp Leu Gly Leu Gln Met Leu Glu Gly Asp 
                165                 170                 175     


Ile Tyr Ser Arg Ala Tyr Ala Gly Glu Ala Ser Gln His Leu Asp Ala 
            180                 185                 190         


Ala Leu Ala Arg Leu Arg Asn Glu Met Asp Asp Pro Ala Leu His Ile 
        195                 200                 205             


Ala Asp Ala Arg Tyr Gln Cys Ile Ala Ala Ile Cys Asp Val Val Ser 
    210                 215                 220                 


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  6

Pro Asn Ser Gly Lys Thr Thr 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Gly Asn Ser Gly Lys Thr Thr 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Gly Asn Ala Gly Lys Thr Thr 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Gly Asn Ser Gly Lys Ser Thr 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Gly Asn Ala Gly Lys Ser Thr 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Pro Asn Ala Gly Ala Ala Thr 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Asn Xaa Gly Lys Xaa Thr 
1               5           


<210>  13
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  13

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Arg Phe Ser Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Ser Gly Glu Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Asp Asp Gly Ser Tyr Arg Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Met Asn Ala Trp Asp Ala Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Glu His Asn Val Lys Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp Ala Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Ser Val Leu Leu Pro Asp Asn His Tyr Leu Ser Phe Gln Ser Lys Leu 
        195                 200                 205             


Phe Lys Asp Pro Asn Glu Gln Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Pro Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  14
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  14

Met Lys Lys Leu Thr Ile Gly Leu Ile Gly Asn Pro Asn Ser Gly Lys 
1               5                   10                  15      


Thr Thr Leu Phe Asn Gln Leu Thr Gly Ser Arg Gln Arg Val Gly Asn 
            20                  25                  30          


Trp Ala Gly Val Thr Val Ser Ala Gly Tyr Asn Ser Asp Asn Val Tyr 
        35                  40                  45              


Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile 
    50                  55                  60                  


Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln 
65                  70                  75                  80  


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
                85                  90                  95      


Tyr Leu Ser Phe Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg 
            100                 105                 110         


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
        115                 120                 125             


Gly Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly Met Val Ser Lys 
    130                 135                 140                 


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
145                 150                 155                 160 


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
                165                 170                 175     


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly 
            180                 185                 190         


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly 
        195                 200                 205             


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
    210                 215                 220                 


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
225                 230                 235                 240 


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
                245                 250                 255     


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
            260                 265                 270         


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Gly Thr Glu 
        275                 280                 285             


Arg Lys Pro Gly Gln Phe Ser Thr Thr Asp His Gln Val Thr Leu Val 
    290                 295                 300                 


Asp Leu Pro Gly Thr Tyr Ser Leu Thr Thr Ile Ser Ser Gln Thr Ser 
305                 310                 315                 320 


Leu Asp Glu Gln Ile Ala Cys His Tyr Ile Leu Ser Gly Asp Ala Asp 
                325                 330                 335     


Leu Leu Ile Asn Val Val Asp Ala Ser Asn Leu Glu Arg Asn Leu Tyr 
            340                 345                 350         


Leu Thr Leu Gln Leu Leu Glu Leu Gly Ile Pro Cys Ile Val Ala Leu 
        355                 360                 365             


Asn Met Leu Asp Ile Ala Glu Lys Gln Asn Ile Arg Ile Glu Ile Asp 
    370                 375                 380                 


Ala Leu Ser Ala Arg Leu Gly Cys Pro Val Ile Pro Leu Val Ser Thr 
385                 390                 395                 400 


Arg Gly Arg Gly Ile Glu Ala Leu Lys Leu Ala Ile Asp Arg Tyr Lys 
                405                 410                 415     


Ala Asn Glu Asn Val Glu Leu Val His Tyr Ala Gln Pro Leu Leu Asn 
            420                 425                 430         


Glu Ala Asp Ser Leu Ala Lys Val Met Pro Ser Asp Ile Pro Leu Lys 
        435                 440                 445             


Gln Arg Arg Trp Leu Gly Leu Gln Met Leu Glu Gly Asp Ile Tyr Ser 
    450                 455                 460                 


Arg Ala Tyr Ala Gly Glu Ala Ser Gln His Leu Asp Ala Ala Leu Ala 
465                 470                 475                 480 


Arg Leu Arg Asn Glu Met Asp Asp Pro Ala Leu His Ile Ala Asp Ala 
                485                 490                 495     


Arg Tyr Gln Cys Ile Ala Ala Ile Cys Asp Val Val Ser 
            500                 505                 


<210>  15
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant nucleic acid

<400>  15
catatgaaaa aactgacaat cggactgatc ggcaatccta atagcggcaa aactacactg       60

ttcaaccagc tgacagggtc tcggcagcgg gtcggaaact gggccggcgt gaccgtcgag      120

aggaagcccg ggcagttctc taccacagac caccaggtga cactggtcga tctgccaggg      180

acttactccc tgactaccat tagctcccag acatctctgg acgaacagat tgcctgccat      240

tatatcctga gcggagacgc tgatctgctg atcaatgtgg tcgatgcatc caacctggag      300

cggaatctgt acctgactct gcagctgctg gaactgggca ttccctgcat cgtggctctg      360

aacatgctgg acattgcaga gaaacagaat atcagaattg aaatcgatgc tctgagtgca      420

aggctggggt gtcccgtgat ccctctggtc tcaacaaggg gccgaggaat tgaggccctg      480

aagctggcta tcgaccgcta caaagcaaac gagaatgtgg aactggtcca ctatgcccag      540

cccctgctga acgaagcaga ctctctggcc aaagtgatgc caagtgatat tcccctgaaa      600

cagcggagat ggctggggct gcagatgctg gagggagaca tctacagccg ggcctacgcc      660

ggggaagcaa gccagcatct ggatgccgct ctggctcgac tgcggaatga gatggacgat      720

cctgccctgc atattgctga cgcccgctac cagtgtattg ctgctatttg cgatgtcgtg      780

tcctaactcg ag                                                          792


<210>  16
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant nucleic acid

<400>  16
tacaacagcg acaacgtcta tatcaccgcc gacaagcaga agaacggcat caaggccaac       60

ttcaagatcc gccacaacat cgaggacggc ggcgtgcagc tcgccgacca ctaccagcag      120

aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcttccag      180

tccaagctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg      240

accgccgccg ggatcactct cggcatggac gagctgtaca agggcggttc cggaggcatg      300

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc      360

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc      420

aagctgaccc tgaagctgat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc      480

gtgaccaccc tgggctacgg cctgcagtgc ttcgcccgct accccgacca catgaagcag      540

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc      600

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg      660

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag      720

ctggagtaca ac                                                          732


<210>  17
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
gactgccggc gttactgttt acaacagcga caacgtc                                37


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Thr Ala Gly Val Thr Val Tyr Asn Ser Asp Asn Val 
1               5                   10          


<210>  19
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
gactgccggc gttactgttt ctgctggtta caacagcgac aacgtc                      46


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Thr Ala Gly Val Thr Val Ser Ala Gly Tyr Asn Ser Asp Asn Val 
1               5                   10                  15  


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
ttctttacgt tcgttgtact ccagcttgtg                                        30


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  22

His Lys Leu Glu Tyr Asn Glu Arg Lys Glu 
1               5                   10  


<210>  23
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
ttctttacgt tcagtaccgt tgtactccag cttgtg                                 36


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  24

His Lys Leu Glu Tyr Asn Gly Thr Glu Arg Lys Glu 
1               5                   10          


<210>  25
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
gactgccggc gtttacaaca gcgacaacgt c                                      31


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Thr Ala Gly Val Tyr Asn Ser Asp Asn Val 
1               5                   10  


<210>  27
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
gactgccggc tctgctggtg tttacaacag cgacaacgtc                             40


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Thr Ala Gly Val Ser Ala Gly Tyr Asn Ser Asp Asn Val 
1               5                   10              


<210>  29
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
ctccttcctc tcgacggtgt tgtactccag cttgtg                                 36


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  30

His Lys Leu Glu Tyr Asn Thr Val Glu Arg Lys Glu 
1               5                   10          


<210>  31
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
ctccttcctc tcgacggttg ttccgttgta ctccagcttg tg                          42


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

His Lys Leu Glu Tyr Asn Gly Thr Thr Val Glu Arg Lys Glu 
1               5                   10                  


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  33

Val Thr Val Glu Arg Lys 
1               5       


<210>  34
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
gactgccggc tacaacagcg acaacgtc                                          28


<210>  35
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
ttccttcctc tcgacggtca cgttgtactc cagcttgtgc                             40


<210>  36
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
gactgccggc tctgctggtt acaacagcga caacgtc                                37


<210>  37
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
ctccttcctc tcgacggtca ctgttccgtt gtactccagc ttgtg                       45


<210>  38
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
gactgccggc gtttacaaca gcgacaacgt c                                      31


<210>  39
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
ctccttcctc tcgacggtgt tgtactccag cttgtg                                 36


<210>  40
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
gactgccggc tctgctggtg tttacaacag cgacaacgtc                             40


<210>  41
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
ctccttcctc tcgacggttg ttccgttgta ctccagcttg tg                          42


<210>  42
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
gactgccggc gttacttaca acagcgacaa cgtc                                   34


<210>  43
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
ctccttcctc tcgacgttgt actccagctt gtgc                                   34


<210>  44
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
gactgccggc gttacttctg ctggttacaa cagcgacaac gtc                         43


<210>  45
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
ctccttcctc tcgactgttc cgttgtactc cagcttgtgc                             40


<210>  46
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  46
gactgccggc gttactgttt acaacagcga caacgtc                                37


<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  47
ttctttacgt tcgttgtact ccagcttgtg                                        30


<210>  48
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
gactgccggc gttactgttt ctgctggtta caacagcgac aacgtc                      46


<210>  49
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  49
ttctttacgt tcagtaccgt tgtactccag cttgtg                                 36


<210>  50
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
gactgccggc gttactgttg agtacaacag cgacaacgtc                             40


<210>  51
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  51
ctccttcctg ttgtactcca gcttgtgcc                                         29


<210>  52
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  52
gactgccggc gttactgttg agtctgctgg ttacaacagc gacaacgtc                   49


<210>  53
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  53
ctccttcctt gttccgttgt actccagctt gtgcc                                  35


<210>  54
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  54
gactgccggc gttactgttg agaggtacaa cagcgacaac gtc                         43


<210>  55
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  55
ttccttgttg tactccagct tgtgcccc                                          28


<210>  56
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  56
gactgccggc gttactgttg agaggtctgc tggttacaac agcgacaacg tc               52


<210>  57
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  57
ttcctttgtt ccgttgtact ccagcttgtg cccc                                   34


<210>  58
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  58
tctgctggt                                                                9


<210>  59
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  59
agtacc                                                                   6


<210>  60
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  60
tgttcc                                                                   6


<210>  61
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  61
cattgcatat gaaaaaactg acaatcggac tgatcg                                 36


<210>  62
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  62
cggtactcga gttaggacac gacatcgc                                          28


<210>  63
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  63
ggtggcgcta gcggtggaaa aaaactgaca atcgg                                  35


<210>  64
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  64
gcgccccata tgaccttgga agtagaggtt ctc                                    33


<210>  65
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  65
cattgcatat ggtgagcaag ggcgag                                            26


<210>  66
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  66
tataccgcta gctccaccct tgtacagctc gtc                                    33


<210>  67
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  67
atgacagcta gcggtggaat ggtgagcaag gg                                     32


<210>  68
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  68
gcgccccata tgaccttgga agtagaggtt ctc                                    33


<210>  69
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  69
cattgcatat gaaaaaactg acaatcggac tgatcg                                 36


<210>  70
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  70
tataccgcta gctccaccgg acacgacatc gc                                     32


<210>  71
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  71
ggtggcgcta gcggtggaaa aaaactgaca atcgg                                  35


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  72
gcgccccata tgaccttgga agtagaggtt ctc                                    33


<210>  73
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  73
cattgcatat ggtgagcaag ggcgag                                            26


<210>  74
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  74
tataccgcta gctccaccct tgtacagctc gtc                                    33


<210>  75
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  75
atgacagcta gcggtggaat ggtgagcaag gg                                     32


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  76
gcgccccata tgaccttgga agtagaggtt ctc                                    33


<210>  77
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  77
cattgcatat gaaaaaactg acaatcggac tgatcg                                 36


<210>  78
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  78
tataccgcta gctccaccgg acacgacatc gc                                     32


<210>  79
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  79
caatcggact gatcggcaat ggtaatagcg gcaaaactac ac                          42


<210>  80
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  80
gtgtagtttt gccgctatta ccattgccga tcagtccgat tg                          42


<210>  81
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  81
gatcggcaat ggtaatgccg gcaaaactac actg                                   34


<210>  82
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  82
cagtgtagtt ttgccggcat taccattgcc gatc                                   34


<210>  83
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  83
ggtaatagcg gcaaatctac actgttcaac cagctg                                 36


<210>  84
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  84
cagctggttg aacagtgtag atttgccgct attacc                                 36


<210>  85
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  85
gatcggcaat ggtaatgccg gcaaatctac actgttcaac cagctg                      46


<210>  86
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  86
cagctggttg aacagtgtag atttgccggc attaccattg ccgatc                      46


<210>  87
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  87
gattagaagc ttatggtgag caagggcgag gag                                    33


<210>  88
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  88
ctgagcgaat tcttaggaca cgacatcgca                                        30


<210>  89
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  89
gctcagaagc ttatgaaaaa actgacaatc gg                                     32


<210>  90
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  90
ctgagcgaat tcttacttgt acagctcgtc c                                      31


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  91

Ala Gly Val Thr Val 
1               5   


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  92

Glu Arg Lys Glu 
1               


