                         SEQUENCE LISTING

<110>  Expression Pathology, Inc.
       KRIZMAN, David B.
       LIAO, Wei-Li
       THYPARAMBIL, Sheeno
       HEMBROUGH, Todd
 
<120>  SRM/MRM Assay for Subtyping Lung Histology

<130>  01152-8030.WO00

<150>  61/647,602

<151>  2012-05-16

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
1               5                   


<210>  2
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Ser Ile Ser Thr Ser Gly Gly Ser Phe Arg 
1               5                   10      


<210>  3
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Pro Asp Ile Phe Glu Ala Gln Ile Ala Gly Leu Arg 
1               5                   10              


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Leu Asp Leu Asp Gly Ile Ile Ala Glu Val Lys 
1               5                   10          


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Ala Ile Gln Tyr Gly Thr Gly Arg 
1               5                   


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys 
1               5                   10      


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Ser Val Pro Ser Ser Thr Glu Lys 
1               5                   


<210>  8
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Pro Ala Ile Ser Arg 
1               5       


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Ala Val Pro Val Leu Val Lys 
1               5               


<210>  10
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Pro Glu Gln Phe Arg 
1               5       


<210>  11
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  11

Thr Pro Ser Ser Ala Ser Thr Val Ser Val Gly Ser Ser Glu Thr Arg 
1               5                   10                  15      


<210>  12
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Arg Gln Ser Ser Val Ser Phe Arg Ser Gly Gly Ser Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ala Ser Ala Ile Thr Pro Ser Val Ser Arg Thr Ser Phe 
            20                  25                  30          


Thr Ser Val Ser Arg Ser Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg 
        35                  40                  45              


Val Ser Leu Ala Gly Ala Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser 
    50                  55                  60                  


Leu Tyr Asn Leu Gly Gly Ser Lys Arg Ile Ser Ile Ser Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Phe Arg Asn Arg Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly 
                85                  90                  95      


Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly 
            100                 105                 110         


Gly Gly Phe Gly Leu Gly Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Pro Gly Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr 
    130                 135                 140                 


Val Asn Gln Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser 
145                 150                 155                 160 


Ile Gln Arg Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn 
                165                 170                 175     


Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln 
            180                 185                 190         


Asn Lys Val Leu Asp Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr 
        195                 200                 205             


Lys Thr Val Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn 
    210                 215                 220                 


Asn Leu Arg Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu 
225                 230                 235                 240 


Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Phe Lys Asn 
                245                 250                 255     


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe 
            260                 265                 270         


Val Met Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu 
        275                 280                 285             


Leu Glu Ala Lys Val Asp Ala Leu Met Asp Glu Ile Asn Phe Met Lys 
    290                 295                 300                 


Met Phe Phe Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp 
305                 310                 315                 320 


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp 
                325                 330                 335     


Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
            340                 345                 350         


Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu 
        355                 360                 365             


Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys His 
    370                 375                 380                 


Glu Ile Ser Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
385                 390                 395                 400 


Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp 
                405                 410                 415     


Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu 
            420                 425                 430         


Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg 
        435                 440                 445             


Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp 
    450                 455                 460                 


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg 
465                 470                 475                 480 


Leu Ser Gly Glu Gly Val Gly Pro Val Asn Ile Ser Val Val Thr Ser 
                485                 490                 495     


Ser Val Ser Ser Gly Tyr Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu 
            500                 505                 510         


Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser 
        515                 520                 525             


Ser Gly Ser Tyr Tyr Ser Ser Ser Ser Gly Gly Val Gly Leu Gly Gly 
    530                 535                 540                 


Gly Leu Ser Val Gly Gly Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly 
545                 550                 555                 560 


Leu Gly Val Gly Phe Gly Ser Gly Gly Gly Ser Ser Ser Ser Val Lys 
                565                 570                 575     


Phe Val Ser Thr Thr Ser Ser Ser Arg Lys Ser Phe Lys Ser 
            580                 585                 590 


<210>  13
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Ile His Phe Ser Ser Pro Val Phe Thr Ser Arg Ser Ala Ala 
1               5                   10                  15      


Phe Ser Gly Arg Gly Ala Gln Val Arg Leu Ser Ser Ala Arg Pro Gly 
            20                  25                  30          


Gly Leu Gly Ser Ser Ser Leu Tyr Gly Leu Gly Ala Ser Arg Pro Arg 
        35                  40                  45              


Val Ala Val Arg Ser Ala Tyr Gly Gly Pro Val Gly Ala Gly Ile Arg 
    50                  55                  60                  


Glu Val Thr Ile Asn Gln Ser Leu Leu Ala Pro Leu Arg Leu Asp Ala 
65                  70                  75                  80  


Asp Pro Ser Leu Gln Arg Val Arg Gln Glu Glu Ser Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Leu Leu Glu Thr Lys Trp Thr Leu Leu Gln Glu 
        115                 120                 125             


Gln Lys Ser Ala Lys Ser Ser Arg Leu Pro Asp Ile Phe Glu Ala Gln 
    130                 135                 140                 


Ile Ala Gly Leu Arg Gly Gln Leu Glu Ala Leu Gln Val Asp Gly Gly 
145                 150                 155                 160 


Arg Leu Glu Ala Glu Leu Arg Ser Met Gln Asp Val Val Glu Asp Phe 
                165                 170                 175     


Lys Asn Lys Tyr Glu Asp Glu Ile Asn His Arg Thr Ala Ala Glu Asn 
            180                 185                 190         


Glu Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Ser Lys 
        195                 200                 205             


Val Glu Leu Glu Ala Lys Val Asp Ala Leu Asn Asp Glu Ile Asn Phe 
    210                 215                 220                 


Leu Arg Thr Leu Asn Glu Thr Glu Leu Thr Glu Leu Gln Ser Gln Ile 
225                 230                 235                 240 


Ser Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp 
                245                 250                 255     


Leu Asp Gly Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Met Ala 
            260                 265                 270         


Lys Cys Ser Arg Ala Glu Ala Glu Ala Trp Tyr Gln Thr Lys Phe Glu 
        275                 280                 285             


Thr Leu Gln Ala Gln Ala Gly Lys His Gly Asp Asp Leu Arg Asn Thr 
    290                 295                 300                 


Arg Asn Glu Ile Ser Glu Met Asn Arg Ala Ile Gln Arg Leu Gln Ala 
305                 310                 315                 320 


Glu Ile Asp Asn Ile Lys Asn Gln Arg Ala Lys Leu Glu Ala Ala Ile 
                325                 330                 335     


Ala Glu Ala Glu Glu Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Ala 
            340                 345                 350         


Lys Gln Glu Glu Leu Glu Ala Ala Leu Gln Arg Gly Lys Gln Asp Met 
        355                 360                 365             


Ala Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala 
    370                 375                 380                 


Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
385                 390                 395                 400 


Ser Arg Leu Ala Gly Asp Gly Val Gly Ala Val Asn Ile Ser Val Met 
                405                 410                 415     


Asn Ser Thr Gly Gly Ser Ser Ser Gly Gly Gly Ile Gly Leu Thr Leu 
            420                 425                 430         


Gly Gly Thr Met Gly Ser Asn Ala Leu Ser Phe Ser Ser Ser Ala Gly 
        435                 440                 445             


Pro Gly Leu Leu Lys Ala Tyr Ser Ile Arg Thr Ala Ser Ala Ser Arg 
    450                 455                 460                 


Arg Ser Ala Arg Asp 
465                 


<210>  14
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Pro Pro Pro Leu Leu Gln Pro Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Asn Val Glu Pro Ser Gly Ala Thr Leu Ile Arg Ile Pro Leu His 
            20                  25                  30          


Arg Val Gln Pro Gly Arg Arg Ile Leu Asn Leu Leu Arg Gly Trp Arg 
        35                  40                  45              


Glu Pro Ala Glu Leu Pro Lys Leu Gly Ala Pro Ser Pro Gly Asp Lys 
    50                  55                  60                  


Pro Ile Phe Val Pro Leu Ser Asn Tyr Arg Asp Val Gln Tyr Phe Gly 
65                  70                  75                  80  


Glu Ile Gly Leu Gly Thr Pro Pro Gln Asn Phe Thr Val Ala Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Arg Arg Cys His Phe Phe 
            100                 105                 110         


Ser Val Pro Cys Trp Leu His His Arg Phe Asp Pro Lys Ala Ser Ser 
        115                 120                 125             


Ser Phe Gln Ala Asn Gly Thr Lys Phe Ala Ile Gln Tyr Gly Thr Gly 
    130                 135                 140                 


Arg Val Asp Gly Ile Leu Ser Glu Asp Lys Leu Thr Ile Gly Gly Ile 
145                 150                 155                 160 


Lys Gly Ala Ser Val Ile Phe Gly Glu Ala Leu Trp Glu Pro Ser Leu 
                165                 170                 175     


Val Phe Ala Phe Ala His Phe Asp Gly Ile Leu Gly Leu Gly Phe Pro 
            180                 185                 190         


Ile Leu Ser Val Glu Gly Val Arg Pro Pro Met Asp Val Leu Val Glu 
        195                 200                 205             


Gln Gly Leu Leu Asp Lys Pro Val Phe Ser Phe Tyr Leu Asn Arg Asp 
    210                 215                 220                 


Pro Glu Glu Pro Asp Gly Gly Glu Leu Val Leu Gly Gly Ser Asp Pro 
225                 230                 235                 240 


Ala His Tyr Ile Pro Pro Leu Thr Phe Val Pro Val Thr Val Pro Ala 
                245                 250                 255     


Tyr Trp Gln Ile His Met Glu Arg Val Lys Val Gly Pro Gly Leu Thr 
            260                 265                 270         


Leu Cys Ala Lys Gly Cys Ala Ala Ile Leu Asp Thr Gly Thr Ser Leu 
        275                 280                 285             


Ile Thr Gly Pro Thr Glu Glu Ile Arg Ala Leu His Ala Ala Ile Gly 
    290                 295                 300                 


Gly Ile Pro Leu Leu Ala Gly Glu Tyr Ile Ile Leu Cys Ser Glu Ile 
305                 310                 315                 320 


Pro Lys Leu Pro Ala Val Ser Phe Leu Leu Gly Gly Val Trp Phe Asn 
                325                 330                 335     


Leu Thr Ala His Asp Tyr Val Ile Gln Thr Thr Arg Asn Gly Val Arg 
            340                 345                 350         


Leu Cys Leu Ser Gly Phe Gln Ala Leu Asp Val Pro Pro Pro Ala Gly 
        355                 360                 365             


Pro Phe Trp Ile Leu Gly Asp Val Phe Leu Gly Thr Tyr Val Ala Val 
    370                 375                 380                 


Phe Asp Arg Gly Asp Met Lys Ser Ser Ala Arg Val Gly Leu Ala Arg 
385                 390                 395                 400 


Ala Arg Thr Arg Gly Ala Asp Leu Gly Trp Gly Glu Thr Ala Gln Ala 
                405                 410                 415     


Gln Phe Pro Gly 
            420 


<210>  15
<211>  1254
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Asp Thr Arg 
    450                 455                 460                 


Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala 
465                 470                 475                 480 


Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
                485                 490                 495     


Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro 
            500                 505                 510         


Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly 
        515                 520                 525             


Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
    530                 535                 540                 


Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala 
545                 550                 555                 560 


Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
                565                 570                 575     


Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro 
            580                 585                 590         


Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly 
        595                 600                 605             


Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
    610                 615                 620                 


Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala 
625                 630                 635                 640 


Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
                645                 650                 655     


Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro 
            660                 665                 670         


Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly 
        675                 680                 685             


Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
    690                 695                 700                 


Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala 
705                 710                 715                 720 


Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
                725                 730                 735     


Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro 
            740                 745                 750         


Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly 
        755                 760                 765             


Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
    770                 775                 780                 


Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala 
785                 790                 795                 800 


Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
                805                 810                 815     


Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro 
            820                 825                 830         


Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly 
        835                 840                 845             


Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
    850                 855                 860                 


Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala 
865                 870                 875                 880 


Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
                885                 890                 895     


Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro 
            900                 905                 910         


Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly 
        915                 920                 925             


Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg 
    930                 935                 940                 


Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala 
945                 950                 955                 960 


Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr 
                965                 970                 975     


Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser 
            980                 985                 990         


Ile Pro Ser His His Ser Asp Thr  Pro Thr Thr Leu Ala  Ser His Ser 
        995                 1000                 1005             


Thr Lys  Thr Asp Ala Ser Ser  Thr His His Ser Ser  Val Pro Pro 
    1010                 1015                 1020             


Leu Thr  Ser Ser Asn His Ser  Thr Ser Pro Gln Leu  Ser Thr Gly 
    1025                 1030                 1035             


Val Ser  Phe Phe Phe Leu Ser  Phe His Ile Ser Asn  Leu Gln Phe 
    1040                 1045                 1050             


Asn Ser  Ser Leu Glu Asp Pro  Ser Thr Asp Tyr Tyr  Gln Glu Leu 
    1055                 1060                 1065             


Gln Arg  Asp Ile Ser Glu Met  Phe Leu Gln Ile Tyr  Lys Gln Gly 
    1070                 1075                 1080             


Gly Phe  Leu Gly Leu Ser Asn  Ile Lys Phe Arg Pro  Gly Ser Val 
    1085                 1090                 1095             


Val Val  Gln Leu Thr Leu Ala  Phe Arg Glu Gly Thr  Ile Asn Val 
    1100                 1105                 1110             


His Asp  Val Glu Thr Gln Phe  Asn Gln Tyr Lys Thr  Glu Ala Ala 
    1115                 1120                 1125             


Ser Arg  Tyr Asn Leu Thr Ile  Ser Asp Val Ser Val  Ser Asp Val 
    1130                 1135                 1140             


Pro Phe  Pro Phe Ser Ala Gln  Ser Gly Ala Gly Val  Pro Gly Trp 
    1145                 1150                 1155             


Gly Ile  Ala Leu Leu Val Leu  Val Cys Val Leu Val  Ala Leu Ala 
    1160                 1165                 1170             


Ile Val  Tyr Leu Ile Ala Leu  Ala Val Cys Gln Cys  Arg Arg Lys 
    1175                 1180                 1185             


Asn Tyr  Gly Gln Leu Asp Ile  Phe Pro Ala Arg Asp  Thr Tyr His 
    1190                 1195                 1200             


Pro Met  Ser Glu Tyr Pro Thr  Tyr His Thr His Gly  Arg Tyr Val 
    1205                 1210                 1215             


Pro Pro  Ser Ser Thr Asp Arg  Ser Pro Tyr Glu Lys  Val Ser Ala 
    1220                 1225                 1230             


Gly Asn  Gly Gly Ser Ser Leu  Ser Tyr Thr Asn Pro  Ala Val Ala 
    1235                 1240                 1245             


Ala Thr  Ser Ala Asn Leu 
    1250                 


<210>  16
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Met Ser Pro Lys His Thr Thr Pro Phe Ser Val Ser Asp Ile 
1               5                   10                  15      


Leu Ser Pro Leu Glu Glu Ser Tyr Lys Lys Val Gly Met Glu Gly Gly 
            20                  25                  30          


Gly Leu Gly Ala Pro Leu Ala Ala Tyr Arg Gln Gly Gln Ala Ala Pro 
        35                  40                  45              


Pro Thr Ala Ala Met Gln Gln His Ala Val Gly His His Gly Ala Val 
    50                  55                  60                  


Thr Ala Ala Tyr His Met Thr Ala Ala Gly Val Pro Gln Leu Ser His 
65                  70                  75                  80  


Ser Ala Val Gly Gly Tyr Cys Asn Gly Asn Leu Gly Asn Met Ser Glu 
                85                  90                  95      


Leu Pro Pro Tyr Gln Asp Thr Met Arg Asn Ser Ala Ser Gly Pro Gly 
            100                 105                 110         


Trp Tyr Gly Ala Asn Pro Asp Pro Arg Phe Pro Ala Ile Ser Arg Phe 
        115                 120                 125             


Met Gly Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly Leu Gly 
    130                 135                 140                 


Ser Leu Gly Asp Val Ser Lys Asn Met Ala Pro Leu Pro Ser Ala Pro 
145                 150                 155                 160 


Arg Arg Lys Arg Arg Val Leu Phe Ser Gln Ala Gln Val Tyr Glu Leu 
                165                 170                 175     


Glu Arg Arg Phe Lys Gln Gln Lys Tyr Leu Ser Ala Pro Glu Arg Glu 
            180                 185                 190         


His Leu Ala Ser Met Ile His Leu Thr Pro Thr Gln Val Lys Ile Trp 
        195                 200                 205             


Phe Gln Asn His Arg Tyr Lys Met Lys Arg Gln Ala Lys Asp Lys Ala 
    210                 215                 220                 


Ala Gln Gln Gln Leu Gln Gln Asp Ser Gly Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Thr Gly Cys Pro Gln Gln Gln Gln Ala Gln Gln Gln Ser Pro Arg 
                245                 250                 255     


Arg Val Ala Val Pro Val Leu Val Lys Asp Gly Lys Pro Cys Gln Ala 
            260                 265                 270         


Gly Ala Pro Ala Pro Gly Ala Ala Ser Leu Gln Gly His Ala Gln Gln 
        275                 280                 285             


Gln Ala Gln His Gln Ala Gln Ala Ala Gln Ala Ala Ala Ala Ala Ile 
    290                 295                 300                 


Ser Val Gly Ser Gly Gly Ala Gly Leu Gly Ala His Pro Gly His Gln 
305                 310                 315                 320 


Pro Gly Ser Ala Gly Gln Ser Pro Asp Leu Ala His His Ala Ala Ser 
                325                 330                 335     


Pro Ala Ala Leu Gln Gly Gln Val Ser Ser Leu Ser His Leu Asn Ser 
            340                 345                 350         


Ser Gly Ser Asp Tyr Gly Thr Met Ser Cys Ser Thr Leu Leu Tyr Gly 
        355                 360                 365             


Arg Thr Trp 
    370     


<210>  17
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asn Phe Glu Thr Ser Arg Cys Ala Thr Leu Gln Tyr Cys Pro Asp 
1               5                   10                  15      


Pro Tyr Ile Gln Arg Phe Val Glu Thr Pro Ala His Phe Ser Trp Lys 
            20                  25                  30          


Glu Ser Tyr Tyr Arg Ser Thr Met Ser Gln Ser Thr Gln Thr Asn Glu 
        35                  40                  45              


Phe Leu Ser Pro Glu Val Phe Gln His Ile Trp Asp Phe Leu Glu Gln 
    50                  55                  60                  


Pro Ile Cys Ser Val Gln Pro Ile Asp Leu Asn Phe Val Asp Glu Pro 
65                  70                  75                  80  


Ser Glu Asp Gly Ala Thr Asn Lys Ile Glu Ile Ser Met Asp Cys Ile 
                85                  90                  95      


Arg Met Gln Asp Ser Asp Leu Ser Asp Pro Met Trp Pro Gln Tyr Thr 
            100                 105                 110         


Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn Gly Ser 
        115                 120                 125             


Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser Val Thr 
    130                 135                 140                 


Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala Leu Ser 
145                 150                 155                 160 


Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His Ser 
                165                 170                 175     


Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp 
            180                 185                 190         


Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr 
        195                 200                 205             


Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly Ala Val 
    210                 215                 220                 


Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Glu Val 
225                 230                 235                 240 


Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn Glu Gly 
                245                 250                 255     


Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn Ser His 
            260                 265                 270         


Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val Leu Val 
        275                 280                 285             


Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val Leu Tyr 
    290                 295                 300                 


Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro 
305                 310                 315                 320 


Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val Leu Gly 
                325                 330                 335     


Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg 
            340                 345                 350         


Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp Ser Thr 
        355                 360                 365             


Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr His Gly 
    370                 375                 380                 


Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp Glu Leu 
385                 390                 395                 400 


Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys 
                405                 410                 415     


Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile 
            420                 425                 430         


Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln 
        435                 440                 445             


Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser Ser Pro 
    450                 455                 460                 


Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val Ser Gln 
465                 470                 475                 480 


Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr Ile Pro 
                485                 490                 495     


Asp Gly Met Gly Ala Asn Ile Pro Met Met Gly Thr His Met Pro Met 
            500                 505                 510         


Ala Gly Asp Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro Pro Pro 
        515                 520                 525             


Leu Ser Met Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro Tyr Pro 
    530                 535                 540                 


Thr Asp Cys Ser Ile Val Ser Phe Leu Ala Arg Leu Gly Cys Ser Ser 
545                 550                 555                 560 


Cys Leu Asp Tyr Phe Thr Thr Gln Gly Leu Thr Thr Ile Tyr Gln Ile 
                565                 570                 575     


Glu His Tyr Ser Met Asp Asp Leu Ala Ser Leu Lys Ile Pro Glu Gln 
            580                 585                 590         


Phe Arg His Ala Ile Trp Lys Gly Ile Leu Asp His Arg Gln Leu His 
        595                 600                 605             


Glu Phe Ser Ser Pro Ser His Leu Leu Arg Thr Pro Ser Ser Ala Ser 
    610                 615                 620                 


Thr Val Ser Val Gly Ser Ser Glu Thr Arg Gly Glu Arg Val Ile Asp 
625                 630                 635                 640 


Ala Val Arg Phe Thr Leu Arg Gln Thr Ile Ser Phe Pro Pro Arg Asp 
                645                 650                 655     


Glu Trp Asn Asp Phe Asn Phe Asp Met Asp Ala Arg Arg Asn Lys Gln 
            660                 665                 670         


Gln Arg Ile Lys Glu Glu Gly Glu 
        675                 680 


