                         SEQUENCE LISTING

<110>  MI, Sha
 
<120>  LINGO-2 ANTAGONISTS FOR TREATMENT OF CONDITIONS INVOLVING MOTOR 
       NEURONS

<130>  2159.361PC02/EJH/CLD

<140>  To be assigned
<141>  Herewith

<150>  61/798,398
<151>  2013-03-15

<150>  61/646,611
<151>  2012-05-14

<160>  31   

<170>  PatentIn version 3.5

<210>  1
<211>  2792
<212>  DNA
<213>  Homo sapiens

<400>  1
aatttagaga agatgtaggg agtgttcaac atgttcgttg tggaagagaa agagctaaga       60

gagaggagct taaagacaca aacgggtaga atcaaggagt gtgctctcaa atgagaggaa      120

caggagtgac attaaccttg aaatgctcgg agactctact ccttcatgac agtaggagga      180

taattaacaa tagatacaaa tgcaggaatt gatgagtgcc atcagaaagc tgtatcatga      240

gctgcctgca cttctaaagt gtccagtgga tttttaatca catgagcctg gaaatagggt      300

tatgaaaaga agctcagagc agagcaccga aagtggccac taccagcatg aagagcccaa      360

caattcaaac tggtgaagtg agaaaaacag aatgcagctt tcaaggttcg tttcaagcag      420

ttggcttgtg ggactctgag agatgctgct gcccatgaca tgcgggaatt atcatgatca      480

actacccagc ttggatttca tccagtggcc aagagctttg tgtgggagac ggcaagggtt      540

ggatttttca aaagagtaaa ccaggataaa tcatgaggaa cctataaccc ttttggccac      600

atgcaaaaaa gcaagacccg tgaccaaggt gtagactaag aagtggagtc atgcttcaca      660

cggccatatc atgctggcag ccattcctgg gtctggctgt ggtgttaatc ttcatgggat      720

ccaccattgg ctgccccgct cgctgtgagt gctctgccca gaacaaatct gttagctgtc      780

acagaaggcg attgatcgcc atcccagagg gcattcccat cgaaaccaaa atcttggacc      840

tcagtaaaaa caggctaaaa agcgtcaacc ctgaagaatt catatcatat cctctgctgg      900

aagagataga cttgagtgac aacatcattg ccaatgtgga accaggagca ttcaacaatc      960

tctttaacct gcgttccctc cgcctaaaag gcaatcgtct aaagctggtc cctttgggag     1020

tattcacggg gctgtccaat ctcactaagc ttgacattag tgagaataag attgtcattt     1080

tactagacta catgttccaa gatctacata acctgaagtc tctagaagtg ggggacaatg     1140

atttggttta tatatcacac agggcattca gtgggcttct tagcttggag cagctcaccc     1200

tggagaaatg caacttaaca gcagtaccaa cagaagccct ctcccacctc cgcagcctca     1260

tcagcctgca tctgaagcat ctcaatatca acaatatgcc tgtgtatgcc tttaaaagat     1320

tgttccacct gaaacaccta gagattgact attggccttt actggatatg atgcctgcca     1380

atagcctcta cggtctcaac ctcacatccc tttcagtcac caacaccaat ctgtctactg     1440

tacccttcct tgcctttaaa cacctggtat acctgactca ccttaacctc tcctacaatc     1500

ccatcagcac tattgaagca ggcatgttct ctgacctgat ccgccttcag gagcttcata     1560

tagtgggggc ccagcttcgc accattgagc ctcactcctt ccaagggctc cgcttcctac     1620

gcgtgctcaa tgtgtctcag aacctgctgg aaactttgga agagaatgtc ttctcctccc     1680

ctagggctct ggaggtcttg agcattaaca acaaccctct ggcctgtgac tgccgccttc     1740

tctggatctt gcagcgacag cccaccctgc agtttggtgg ccagcaacct atgtgtgctg     1800

gcccagacac catccgtgag aggtctttca aggatttcca tagcactgcc ctttcttttt     1860

actttacctg caaaaaaccc aaaatccgtg aaaagaagtt gcagcatctg ctagtagatg     1920

aagggcagac agtccagcta gaatgcagtg cagatggaga cccgcagcct gtgatttcct     1980

gggtgacacc ccgaaggcgt ttcatcacca ccaagtccaa tggaagagcc accgtgttgg     2040

gtgatggcac cttggaaatc cgctttgccc aggatcaaga cagcgggatg tatgtttgca     2100

tcgctagcaa tgctgctggg aatgatacct tcacagcctc cttaactgtg aaaggattcg     2160

cttcagatcg ttttctttat gcgaacagga cccctatgta catgaccgac tccaatgaca     2220

ccatttccaa tggcaccaat gccaatactt tttccctgga ccttaaaaca atactggtgt     2280

ctacagctat gggctgcttc acattcctgg gagtggtttt attttgtttt cttctccttt     2340

ttgtgtggag ccgagggaaa ggcaagcaca aaaacagcat tgaccttgag tatgtgccca     2400

gaaaaaacaa tggtgctgtt gtggaaggag aggtagctgg acccaggagg ttcaacatga     2460

aaatgatttg aaggcccacc cctcacatta ctgtctcttt gtcaatgtgg gtaatcagta     2520

agacagtatg gcacagtaaa ttactagatt aagaggcagc catgtgcagc tgcccctgta     2580

tcaaaagcag ggtctatgga agcaggagga cttccaatgg agactctcca tcgaaaggca     2640

ggcaggcagg catgtgtcag agcccttcac acagtgggat actaagtgtt tgcgttgcaa     2700

atattggcgt tctggggatc tcagtaatga acctgaatat ttggctcaca ctcacggaca     2760

attattcagc attttctacc actgcaaaaa ac                                   2792


<210>  2
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu His Thr Ala Ile Ser Cys Trp Gln Pro Phe Leu Gly Leu Ala 
1               5                   10                  15      


Val Val Leu Ile Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys 
            20                  25                  30          


Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu 
        35                  40                  45              


Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu 
    50                  55                  60                  


Ser Lys Asn Arg Leu Lys Ser Val Asn Pro Glu Glu Phe Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val 
                85                  90                  95      


Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu 
            100                 105                 110         


Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu 
        115                 120                 125             


Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu 
    130                 135                 140                 


Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val 
145                 150                 155                 160 


Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu 
                165                 170                 175     


Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val 
            180                 185                 190         


Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ser Leu His Leu 
        195                 200                 205             


Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu 
    210                 215                 220                 


Phe His Leu Lys His Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Met 
225                 230                 235                 240 


Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Val 
                245                 250                 255     


Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu 
            260                 265                 270         


Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile 
        275                 280                 285             


Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Ile 
    290                 295                 300                 


Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu 
305                 310                 315                 320 


Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu 
                325                 330                 335     


Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile 
            340                 345                 350         


Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Leu Gln 
        355                 360                 365             


Arg Gln Pro Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly 
    370                 375                 380                 


Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala 
385                 390                 395                 400 


Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys 
                405                 410                 415     


Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys 
            420                 425                 430         


Ser Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg 
        435                 440                 445             


Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly 
    450                 455                 460                 


Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met 
465                 470                 475                 480 


Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala 
                485                 490                 495     


Ser Leu Thr Val Lys Gly Phe Ala Ser Asp Arg Phe Leu Tyr Ala Asn 
            500                 505                 510         


Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Ile Ser Asn Gly 
        515                 520                 525             


Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val Ser 
    530                 535                 540                 


Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys Phe 
545                 550                 555                 560 


Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn Ser 
                565                 570                 575     


Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Val Glu 
            580                 585                 590         


Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile 
        595                 600                 605     


<210>  3
<211>  3669
<212>  DNA
<213>  Mus musculus

<400>  3
gccagtgcac tctagaaacc cagcctgcat gtagaaagcc ctgtctactg cagaagatga       60

ttcctgcccc gggttaaatg tgcacaactc gcggaaatgc cagtaccttc cacctgaagg      120

cacttagtgg ctagaaaacc agcaatctac cccgaaacac actgtactaa acacagcaag      180

agaccacaat gattggacat atacctatga agatccactt tgagaaagat gccagttgtt      240

ccacaggatg cactttgaga atgaattcat tctagctggt acagcaaaag gagtgcatta      300

aggcccgtaa ccaaggtgta gacaaagaag tggagtcatg cttcacacgg ctataccatg      360

ctggcagcca ttcctgggtc tggctgtggt gttactctta atgggatcca ccattggctg      420

tcctgctcgc tgtgagtgct ccgcccagaa caaatctgtt agctgccaca gaagacgatt      480

gctcgcgatc ccagaaggca ttcccattga gaccaaaatc ttggacctga gcaaaaatcg      540

actaaagagc ataaaccctg aagagttcat ctcatatcct ctgttggagg agatagactt      600

gagcgacaac attattgcca atgtggagcc tggggcattt aacaatctct ttaacctgcg      660

ttccctccgc ctaaaaggca atcgccttaa gttggtccct ttaggagtat tcacaggact      720

gtccaacctc accaagcttg acattagtga gaataagatt gtcattttgc tggactacat      780

gttccaggat ctgcataacc tgaagtctct agaagtgggg gacaatgatt tagtgtatat      840

ctcacacagg gccttcagcg gactacttag cttggagcag ctcaccctgg agaagtgcaa      900

cttgacagca gtaccaacag aagccctttc ccatctccgc agcctcatcg ccctgcatct      960

gaagcatctc aatatcaaca atatgcctgt gtatgccttt aaaagattgt tccacctgaa     1020

aaacctagag atcgactatt ggcctttgtt ggatttgatg ccagccaaca gcctctatgg     1080

tctcaacctc acgtcccttt caatcaccaa caccaacctg tccactgtcc ccttcctcgc     1140

ctttaaacac cttgtatacc tgacccacct taacctctcc tacaatccca tcagcactat     1200

tgaagctggc atgttctctg acctgatccg cctacaggag cttcatatag tgggggccca     1260

gctccgcact attgagcctc actccttcca agggctccgc ttcctccgtg tgctcaatgt     1320

atctcagaac ctgctggaaa cattggaaga gaacgtcttc tcctccccta gggctttgga     1380

ggtcctgagc attaacaaca acccactagc ctgtgactgc cgactcctct ggctcctgca     1440

gcgacaaccc aacctgcagt ttgggggcca gcagcccatg tgtgctgggc cagacaccat     1500

ccgtgagaga tcatttaagg atttccatag cactgctctt tctttttatt ttacctgcaa     1560

aaaacccaaa atccgtgaaa agaagttaca gcatctcctc gtggatgaag ggcaaacggt     1620

ccagctggag tgcaacgctg atggagaccc gcagcccgtg atttcctggg tgacacctcg     1680

aaggcgtttt atcaccacca agtccaacgg aagggccact gtgttgggtg atggcacctt     1740

ggaaatccgt tttgcccagg atcaagacag tgggatgtat gtttgcatcg cgagcaacgc     1800

tgctgggaac gataccttca cagcatctct cactgtgaag ggattcacgt cagaccgctt     1860

cctttacgca aacaggaccc ctatgtacat gactgactcc aacgacaccg tttccaacgg     1920

cactaatgcc aatactttct ccctggacct taaaacaata ctggtatcta cagccatggg     1980

ctgtttcaca ttcctgggag tggttttatt ttgttttctc cttctttttg tgtggagccg     2040

agggaaaggc aagcacaaaa acagcattga ccttgagtat gtgccccgaa aaaacaatgg     2100

tgctgttgtg gaaggggagg tggctggccc caggaggttc aacatgaaaa tgatctaagg     2160

gcccaccaca cactactgtc tctctgttac tgttggtcgt gagtaagacg tctgatagag     2220

tgactcgatc acaaggttat cgggcagctt tgcgcagctg cccctgtgtc aaagcagggt     2280

ccatggaagc aggaagactt ctcatggaga ctggctgatt agaggcaggc aggcatgtgt     2340

cagagccctt cacacagtgg gatactaatt gtttgcattg caaatattgg cattctgggg     2400

atctcagcaa tgaacctgaa cctttggctc atgctgatgg acaataattc aacattttct     2460

accactgcaa aactaaaagg aaaaaaaatt aaaaagaaca acctacagtg taggatttac     2520

atattaaaaa gacacatttg tctaaaacat actctacagt caaatttgta tttattatca     2580

tttgttaaaa ccttgcatca tacaatactg ttggttcagc accaaaaaga gatcaatata     2640

ttcttttttt tgaaacatat atgctgtata tgttttaaag caatatgaat gagaggttgt     2700

gcttttagtt actcaccagt atagatccaa gtgtggtttc accttccttt tacctgcaga     2760

taaacctgag aatagatccc tggaatacta ggcagagatg tgttgagatg tgtatgtctg     2820

atgtaggatg ccaagaaaca agacccaagt caaaactgct caactctgtt aacttctgtt     2880

actataaata aaggcatgtg cctagttttg atacagaatg gaatattttt tatacataca     2940

ctaccaacct ggaccagttt actgtaacag aagcccttgg tttctccaga aggcggtaca     3000

tcgctagggg tacctataga atacaaggta ggtgtcactc ttaaaagtaa tccatgtagc     3060

tactgcttag ttttactttc gccagtcact gctaatgggt taatgaccaa tggaaaagag     3120

aatattgatt atatagaatt atttggcaat attcaccaat agctaatatc aataattctg     3180

ttgtccgaaa gccctctgaa taaggaggtt tcagaagtca ataggaagca gggagagaca     3240

agagcatcac agcagcgatt cagccaatga tctctttcaa atgtggcagc tgcctgccgg     3300

atggctacaa atcaaaggga atacgctgca catgccagcc caacttctat ccaagtacta     3360

tacacagagt aggaccacag ttaggcaact tcaggatatt cctctgcttc ctgatcaaga     3420

tctttagttt catattgaaa accatattac acagctacga ggaatatgtt ttgtgtgaaa     3480

gaagtaaaag tagtgaaaga aaaaccaata tagatctaaa aaacaatgtt ttgttccttc     3540

actggggaag agctaagctt atagttctac aaatatgtaa tgctgtgcca attcttttac     3600

cttcttgacc tgagcatatt tgcccaatta agttgatatt aatgttacta atgcaaacat     3660

aaccagaaa                                                             3669


<210>  4
<211>  606
<212>  PRT
<213>  Mus musculus

<400>  4

Met Leu His Thr Ala Ile Pro Cys Trp Gln Pro Phe Leu Gly Leu Ala 
1               5                   10                  15      


Val Val Leu Leu Leu Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys 
            20                  25                  30          


Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu 
        35                  40                  45              


Leu Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu 
    50                  55                  60                  


Ser Lys Asn Arg Leu Lys Ser Ile Asn Pro Glu Glu Phe Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val 
                85                  90                  95      


Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu 
            100                 105                 110         


Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu 
        115                 120                 125             


Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu 
    130                 135                 140                 


Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val 
145                 150                 155                 160 


Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu 
                165                 170                 175     


Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val 
            180                 185                 190         


Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ala Leu His Leu 
        195                 200                 205             


Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu 
    210                 215                 220                 


Phe His Leu Lys Asn Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Leu 
225                 230                 235                 240 


Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Ile 
                245                 250                 255     


Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu 
            260                 265                 270         


Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile 
        275                 280                 285             


Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Ile 
    290                 295                 300                 


Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu 
305                 310                 315                 320 


Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu 
                325                 330                 335     


Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile 
            340                 345                 350         


Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Leu Leu Gln 
        355                 360                 365             


Arg Gln Pro Asn Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly 
    370                 375                 380                 


Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala 
385                 390                 395                 400 


Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys 
                405                 410                 415     


Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys 
            420                 425                 430         


Asn Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg 
        435                 440                 445             


Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly 
    450                 455                 460                 


Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met 
465                 470                 475                 480 


Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala 
                485                 490                 495     


Ser Leu Thr Val Lys Gly Phe Thr Ser Asp Arg Phe Leu Tyr Ala Asn 
            500                 505                 510         


Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Val Ser Asn Gly 
        515                 520                 525             


Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val Ser 
    530                 535                 540                 


Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys Phe 
545                 550                 555                 560 


Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn Ser 
                565                 570                 575     


Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Val Glu 
            580                 585                 590         


Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile 
        595                 600                 605     


<210>  5
<211>  2941
<212>  DNA
<213>  Rattus norvegicus

<400>  5
gtgccagggc actctagaaa cccagcctgc atgtagacag ccctgcctac tgcagaagat       60

gattcctgcc ccgggttaaa cgtgtacaac tcgtggaaat gccagtacct tccacctgaa      120

ggcacttagt ggctagaaaa ccagcaatct accccgaaac acactgtact aaacacagca      180

agagaccaca atgattggac atagacctat aaggatacac tttgagaaag atgccagttg      240

ttcctcagga tgcactttga aaatgcagtc attctagctg gtaccgcaaa atgagtgcat      300

taaggcccat aaccaaggtg tagaataaac agtggagtca tgcttcacac ggctatacca      360

tgctggcagc cattcctggg tctggctatg gtgttactct tcatgggatc caccattggc      420

tgtcctgctc gctgtgagtg ctctgcccag aacaaatctg ttagctgcca cagaagacgc      480

ttgatcgcga tccccgaagg cattcccatt gagaccaaaa tcttggacct gagcaaaaat      540

cgactaaaga gcataaaccc cgaagaattc atctcatatc ctctgttgga ggagatagac      600

ttgagcgaca acatcatcgc caatgtagaa cctggggcat ttaacaatct ctttaacctg      660

cgttccctcc gcctaaaagg caatcgcctt aagttggtcc ctttgggagt attcacggga      720

ctgtccaacc tcaccaagct tgacattagt gagaataaga ttgtcatttt gctggactac      780

atgttccagg atctgcataa cctgaagtct ctagaagtgg gggacaatga tttggtttat      840

atatcacaca gggccttcag tggactattt agcttggagc agctcaccct ggagaagtgc      900

aacttgacag cggtaccaac agaagccctt tcccatctcc gcagcctcat caccctgcat      960

ctgaagcatc tcaatatcaa caatatgcct gtgtatgcct ttaaaagatt attccacctg     1020

aaacaactag agatcgacta ttggccattg ctggatatga tgccagccaa tagcctctat     1080

ggtctcaacc tcacatccct ctcgatcact aacaccaacc tgtccactgt ccctttcctc     1140

gcctttaaac accttgtata cctgacccac cttaacctct cctacaatcc catcagcact     1200

attgaagcag gcatgttctc tgacctgatc cgcctacagg agcttcatgt agtcggggcc     1260

cagctccgca ccattgaacc tcactccttc caagggctcc gcttcctccg cgtgctcaat     1320

gtatctcaga acctgctgga aacattggaa gagaatgtct tctcttcccc tagggctttg     1380

gaggtcctga gcattaacaa taacccacta gcgtgcgact gccgacttct ctggctcctg     1440

cagcgacagg ccaccctgca gtttggaggc cagcagccca tgtgtgccgg gccagacacc     1500

atacgtgaga ggtcatttaa ggatttccat agcactgctc tttcttttta ttttacctgc     1560

aaaaaaccca aaatccgtga aaagaagtta cagcacctcc tagtggacga aggacagacg     1620

gtccagctgg agtgcaacgc ggatggagac ccccagcccg tgatttcctg ggtgacacct     1680

cgaaggcgtt ttatcaccac caagtccaac ggaagggcca ctgtgttggg tgatggcacc     1740

ttagaaatcc gtttcgccca ggatcaagac agtgggatgt atgtttgcat agctagcaat     1800

gctgctggga atgacacctt cacggcatct ctcactgtga agggattcac ttcagaccgc     1860

ttcctttacg caaacaggac ccctatgtac atgactgact ccaatgacac cgtttccaac     1920

ggcactaatg ccaatacttt ttccctggac cttaaaacaa tactggtatc tacagccatg     1980

ggctgtttca cattcctggg agtggtttta ttttgttttc tccttctttt tgtgtggagc     2040

cgaggaaagg gcaaacacaa aaacagcatt gaccttgagt atgtgccccg aaaaaacaat     2100

ggtgctgttg cagaagggga ggtggctgga cccaggaggt tcaacatgaa aatgatataa     2160

gggcccacca cacacacact actactgtct ctgtgttact gttggtaatg agtaagacgt     2220

ctgatatagc gagtccatca caaggtgatc aggcagcttc acacagctgc ccctgtgtca     2280

aagcagggtc catggaagct ggaagacttc tcatggacac tggctgatta gaggcaggca     2340

ggcatgtgtc agagcccttc acacagtggg atactaattg tttgcattgc aaatattggc     2400

attctgggga tctcagtaat gaccctgaac ctttggctca tgctgacgga caaaaattca     2460

acattttcta ccactgcaaa actaaaagaa aaaaaattta aaaggaacaa cctacagtgt     2520

aggatttaca tattaaaaaa agacacattt gtctaaaaca tactctacgg taaaatttgt     2580

atttattatc atttgttaaa accttgcatc atacaatact gttggttcag caccaaaaaa     2640

aaaaaaaaaa aaaaaaagag agatcaatat attctttttt gaaacatata tgctgtatat     2700

gttttaaagc aatatgaatg agaggttgtg cttttagtta ctcaccagta tagatccaag     2760

tgtggtctca ctttcctttt atccgcagag aaacctgaga atagatccct ggaataatag     2820

gctgagatgt gttgagatgt gtatgtctga tgtaggatgc caagatacaa gagcccagtc     2880

aaaactgctc aactctgtta acttctgtta ctataaataa aggcatgtgc ctagttttga     2940

t                                                                     2941


<210>  6
<211>  606
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Leu His Thr Ala Ile Pro Cys Trp Gln Pro Phe Leu Gly Leu Ala 
1               5                   10                  15      


Met Val Leu Leu Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys 
            20                  25                  30          


Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu 
        35                  40                  45              


Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu 
    50                  55                  60                  


Ser Lys Asn Arg Leu Lys Ser Ile Asn Pro Glu Glu Phe Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val 
                85                  90                  95      


Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu 
            100                 105                 110         


Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu 
        115                 120                 125             


Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu 
    130                 135                 140                 


Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val 
145                 150                 155                 160 


Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu 
                165                 170                 175     


Phe Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val 
            180                 185                 190         


Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Thr Leu His Leu 
        195                 200                 205             


Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu 
    210                 215                 220                 


Phe His Leu Lys Gln Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Met 
225                 230                 235                 240 


Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Ile 
                245                 250                 255     


Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu 
            260                 265                 270         


Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile 
        275                 280                 285             


Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Val 
    290                 295                 300                 


Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu 
305                 310                 315                 320 


Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu 
                325                 330                 335     


Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile 
            340                 345                 350         


Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Leu Leu Gln 
        355                 360                 365             


Arg Gln Ala Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly 
    370                 375                 380                 


Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala 
385                 390                 395                 400 


Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys 
                405                 410                 415     


Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys 
            420                 425                 430         


Asn Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg 
        435                 440                 445             


Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly 
    450                 455                 460                 


Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met 
465                 470                 475                 480 


Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala 
                485                 490                 495     


Ser Leu Thr Val Lys Gly Phe Thr Ser Asp Arg Phe Leu Tyr Ala Asn 
            500                 505                 510         


Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Val Ser Asn Gly 
        515                 520                 525             


Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val Ser 
    530                 535                 540                 


Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys Phe 
545                 550                 555                 560 


Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn Ser 
                565                 570                 575     


Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Ala Glu 
            580                 585                 590         


Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile 
        595                 600                 605     


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VH-CDR1

<400>  7

Leu Tyr Trp Met Asn 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VH-CDR2

<400>  8

Ser Ile Ser Pro Ser Gly Gly Trp Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VH-CDR3

<400>  9

Asp His Trp Gly Ser Gly Ser Pro Asp Tyr 
1               5                   10  


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VH

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Gly Gly Trp Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Trp Gly Ser Gly Ser Pro Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VL-CDR1

<400>  11

Thr Gly Ser Ser Arg Asp Val Gly Gly Tyr Asp Tyr Val Ser 
1               5                   10                  


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VL-CDR2

<400>  12

Glu Val Thr Lys Arg Pro Ser 
1               5           


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VL-CDR3

<400>  13

Cys Ser Tyr Ala Gly Ala Asn Thr Tyr Val 
1               5                   10  


<210>  14
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VL

<400>  14

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Thr Gly Ser Ser Arg Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Phe Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Val Ile Ser Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ala 
                85                  90                  95      


Asn Thr Tyr Val Phe Gly Ser Gly Thr Arg Val Thr Val Leu 
            100                 105                 110 


<210>  15
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VH-CDR1

<400>  15
ctttactgga tgaat                                                        15


<210>  16
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VH-CDR2

<400>  16
tctatctctc cttctggtgg ctggactaag tatgctgact ccgttaaagg t                51


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VH-CDR3

<400>  17
gatcattggg gttcagggag ccccgactac                                        30


<210>  18
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VH

<400>  18
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ctttactgga tgaattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttct atctctcctt ctggtggctg gactaagtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc aagagatcat      300

tggggttcag ggagccccga ctactggggc cagggaaccc tggtcaccgt ctcaagc         357


<210>  19
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody C09-VL CDR1

<400>  19
actggatcca gccgtgacgt tggtggttat gattatgtct cc                          42


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VL-CDR2

<400>  20
gaggtcacta agcggccctc a                                                 21


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VL-CDR3

<400>  21
tgctcatatg caggcgccaa cacttatgtc                                        30


<210>  22
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody C09 VL

<400>  22
cagagcgtct tgactcagcc tccctccgcg tccgggtctc ctggacagtc actcaccatc       60

tcctgcactg gatccagccg tgacgttggt ggttatgatt atgtctcctg gttccaacaa      120

cacccaggca aagcccccaa actcgtgatt tctgaggtca ctaagcggcc ctcaggggtc      180

cctgatcggt tctctggctc caagtctggc aacacggcct ccctgaccgt ctctggactc      240

caacctgagg atgaggctga ttattattgc tgctcatatg caggcgccaa cacttatgtc      300

ttcggaagtg ggaccagagt caccgtcctg                                       330


<210>  23
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  23
accttgtata cctgacccac cttaa                                             25


<210>  24
<211>  25
<212>  DNA
<213>  Rattus norvegicus

<400>  24
agagaacatg cctgcttcaa tagtg                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Mus musculus

<400>  25
agagaacatg ccagcttcaa tagtg                                             25


<210>  26
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MGB probe

<400>  26
cctctcctac aatccc                                                       16


<210>  27
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu His Thr Ala Ile Ser Cys Trp Gln Pro Phe Leu Gly Leu Ala 
1               5                   10                  15      


Val Val Leu Ile Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys 
            20                  25                  30          


Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu 
        35                  40                  45              


Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu 
    50                  55                  60                  


Ser Lys Asn Arg Leu Lys Ser Val Asn Pro Glu Glu Phe Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val 
                85                  90                  95      


Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu 
            100                 105                 110         


Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu 
        115                 120                 125             


Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu 
    130                 135                 140                 


Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val 
145                 150                 155                 160 


Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu 
                165                 170                 175     


Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val 
            180                 185                 190         


Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ser Leu His Leu 
        195                 200                 205             


Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu 
    210                 215                 220                 


Phe His Leu Lys His Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Met 
225                 230                 235                 240 


Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Val 
                245                 250                 255     


Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu 
            260                 265                 270         


Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile 
        275                 280                 285             


Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Ile 
    290                 295                 300                 


Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu 
305                 310                 315                 320 


Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu 
                325                 330                 335     


Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile 
            340                 345                 350         


Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Leu Gln 
        355                 360                 365             


Arg Gln Pro Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly 
    370                 375                 380                 


Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala 
385                 390                 395                 400 


Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys 
                405                 410                 415     


Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys 
            420                 425                 430         


Ser Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg 
        435                 440                 445             


Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly 
    450                 455                 460                 


Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met 
465                 470                 475                 480 


Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala 
                485                 490                 495     


Ser Leu Thr Val Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys 
                725             



<210>  28
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  digoxigenin-labeled LINGO-2 anti-sense RNA probe

<400>  28
taatacgact cactataggg acagaagccc tttcccatct                             40


<210>  29
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  digoxigenin-labeled sense RNA probe

<400>  29
taatacgact cactataggg acagaagccc tttcccatct                             40


<210>  30
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  General Structure for an Oligonucleotide used in Preparation of 
       an siRNA Molecule


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (2)..(200)
<223>  nucleotide may be missing

<400>  30
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

nnnnnnnnnn nnnnnnnnnn                                                200


<210>  31
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  General Structure for an Oligonucleotide used in Preparation of 
       an siRNA Molecule


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (2)..(200)
<223>  nucleotide may be missing

<400>  31
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

nnnnnnnnnn nnnnnnnnnn                                                200

