                         SEQUENCE LISTING

<110>  ST. LOUIS UNIVERSITY
       Pozzi, Nicola
       Di Cera, Enrico
       Barranco-Medina, Sergio
 
<120>  RECOMBINANT AUTO-ACTIVATING PROTEASE PRECURSORS

<130>  60216-97

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  295
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  1

Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Ala Leu Leu Glu Ser Tyr 
            20                  25                  30          


Ile Ala Gly Arg Ile Val Ala Gly Ser Asp Ala Glu Ile Gly Met Ser 
        35                  40                  45              


Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys 
    50                  55                  60                  


Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys 
65                  70                  75                  80  


Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu 
                85                  90                  95      


Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu 
            100                 105                 110         


Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp 
        115                 120                 125             


Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro 
    130                 135                 140                 


Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu 
145                 150                 155                 160 


Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly 
                165                 170                 175     


Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln 
            180                 185                 190         


Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val 
        195                 200                 205             


Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala 
    210                 215                 220                 


Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp 
225                 230                 235                 240 


Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr 
                245                 250                 255     


Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys 
            260                 265                 270         


Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys 
        275                 280                 285             


Val Ile Asp Gln Phe Gly Glu 
    290                 295 


<210>  2
<211>  295
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  2

Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Ala Leu Leu Glu Ser Tyr 
            20                  25                  30          


Ile Ala Gly Arg Ile Val Ala Gly Ser Asp Ala Glu Ile Gly Met Ser 
        35                  40                  45              


Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys 
    50                  55                  60                  


Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys 
65                  70                  75                  80  


Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu 
                85                  90                  95      


Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu 
            100                 105                 110         


Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp 
        115                 120                 125             


Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro 
    130                 135                 140                 


Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu 
145                 150                 155                 160 


Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly 
                165                 170                 175     


Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln 
            180                 185                 190         


Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val 
        195                 200                 205             


Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala 
    210                 215                 220                 


Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp 
225                 230                 235                 240 


Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr 
                245                 250                 255     


Gln Met Gly Ile Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys 
            260                 265                 270         


Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys 
        275                 280                 285             


Val Ile Asp Gln Phe Gly Glu 
    290                 295 


<210>  3
<211>  295
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  3

Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr 
            20                  25                  30          


Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser 
        35                  40                  45              


Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys 
    50                  55                  60                  


Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys 
65                  70                  75                  80  


Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu 
                85                  90                  95      


Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu 
            100                 105                 110         


Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp 
        115                 120                 125             


Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro 
    130                 135                 140                 


Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu 
145                 150                 155                 160 


Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly 
                165                 170                 175     


Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln 
            180                 185                 190         


Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val 
        195                 200                 205             


Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala 
    210                 215                 220                 


Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp 
225                 230                 235                 240 


Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr 
                245                 250                 255     


Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys 
            260                 265                 270         


Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys 
        275                 280                 285             


Val Ile Asp Gln Phe Gly Glu 
    290                 295 


<210>  4
<211>  308
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  4

Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly 
1               5                   10                  15      


Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser 
            20                  25                  30          


Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly 
        35                  40                  45              


Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln 
    50                  55                  60                  


Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr 
                85                  90                  95      


Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile 
            100                 105                 110         


Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser 
        115                 120                 125             


Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn 
    130                 135                 140                 


Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe 
145                 150                 155                 160 


Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala 
                165                 170                 175     


Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn 
            180                 185                 190         


Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val 
        195                 200                 205             


Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp 
    210                 215                 220                 


Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys 
225                 230                 235                 240 


Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly 
                245                 250                 255     


Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly 
            260                 265                 270         


Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe 
        275                 280                 285             


Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp 
    290                 295                 300                 


Gln Phe Gly Glu 
305             


<210>  5
<211>  308
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  5

Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly 
1               5                   10                  15      


Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser 
            20                  25                  30          


Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly 
        35                  40                  45              


Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln 
    50                  55                  60                  


Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr 
                85                  90                  95      


Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile 
            100                 105                 110         


Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser 
        115                 120                 125             


Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn 
    130                 135                 140                 


Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe 
145                 150                 155                 160 


Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala 
                165                 170                 175     


Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn 
            180                 185                 190         


Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val 
        195                 200                 205             


Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp 
    210                 215                 220                 


Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys 
225                 230                 235                 240 


Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly 
                245                 250                 255     


Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly 
            260                 265                 270         


Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe 
        275                 280                 285             


Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp 
    290                 295                 300                 


Gln Phe Gly Glu 
305             


<210>  6
<211>  461
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  6

Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg 
            20                  25                  30          


Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu 
        35                  40                  45              


Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys 
    50                  55                  60                  


Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu 
65                  70                  75                  80  


Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro 
                85                  90                  95      


Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile 
            100                 105                 110         


Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly 
        115                 120                 125             


Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn 
    130                 135                 140                 


Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys 
145                 150                 155                 160 


Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His 
                165                 170                 175     


Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys 
            180                 185                 190         


Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val 
        195                 200                 205             


Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala 
225                 230                 235                 240 


Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp 
                245                 250                 255     


Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His 
        275                 280                 285             


Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala 
            340                 345                 350         


Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val 
        355                 360                 365             


Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr 
            420                 425                 430         


Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His 
        435                 440                 445             


Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro 
    450                 455                 460     


<210>  7
<211>  419
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  7

Ala Asn Ser Phe Leu Glu Glu Leu Arg His Ser Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Ile Glu Glu Ile Cys Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln 
            20                  25                  30          


Asn Val Asp Asp Thr Leu Ala Phe Trp Ser Lys His Val Asp Gly Asp 
        35                  40                  45              


Gln Cys Leu Val Leu Pro Leu Glu His Pro Cys Ala Ser Leu Cys Cys 
    50                  55                  60                  


Gly His Gly Thr Cys Ile Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys 
65                  70                  75                  80  


Arg Ser Gly Trp Glu Gly Arg Phe Cys Gln Arg Glu Val Ser Phe Leu 
                85                  90                  95      


Asn Cys Ser Leu Asp Asn Gly Gly Cys Thr His Tyr Cys Leu Glu Glu 
            100                 105                 110         


Val Gly Trp Arg Arg Cys Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp 
        115                 120                 125             


Asp Leu Leu Gln Cys His Pro Ala Val Lys Phe Pro Cys Gly Arg Pro 
    130                 135                 140                 


Trp Lys Arg Met Glu Lys Lys Arg Ser His Leu Lys Arg Asp Thr Glu 
145                 150                 155                 160 


Asp Gln Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Met Thr 
                165                 170                 175     


Arg Arg Gly Asp Ser Pro Trp Gln Val Val Leu Leu Asp Ser Lys Lys 
            180                 185                 190         


Lys Leu Ala Cys Gly Ala Val Leu Ile His Pro Ser Trp Val Leu Thr 
        195                 200                 205             


Ala Ala His Cys Met Asp Glu Ser Lys Lys Leu Leu Val Arg Leu Gly 
    210                 215                 220                 


Glu Tyr Asp Leu Arg Arg Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile 
225                 230                 235                 240 


Lys Glu Val Phe Val His Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn 
                245                 250                 255     


Asp Ile Ala Leu Leu His Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr 
            260                 265                 270         


Ile Val Pro Ile Cys Leu Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu 
        275                 280                 285             


Asn Gln Ala Gly Gln Glu Thr Leu Val Thr Gly Trp Gly Tyr His Ser 
    290                 295                 300                 


Ser Arg Glu Lys Glu Ala Lys Arg Asn Arg Thr Phe Val Leu Asn Phe 
305                 310                 315                 320 


Ile Lys Ile Pro Val Val Pro His Asn Glu Cys Ser Glu Val Met Ser 
                325                 330                 335     


Asn Met Val Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Arg 
            340                 345                 350         


Gln Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser Phe 
        355                 360                 365             


His Gly Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys 
    370                 375                 380                 


Gly Leu Leu His Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu 
385                 390                 395                 400 


Asp Trp Ile His Gly His Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser 
                405                 410                 415     


Trp Ala Pro 
            


<210>  8
<211>  419
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  8

Ala Asn Ser Phe Leu Glu Glu Leu Arg His Ser Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Ile Glu Glu Ile Cys Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln 
            20                  25                  30          


Asn Val Asp Asp Thr Leu Ala Phe Trp Ser Lys His Val Asp Gly Asp 
        35                  40                  45              


Gln Cys Leu Val Leu Pro Leu Glu His Pro Cys Ala Ser Leu Cys Cys 
    50                  55                  60                  


Gly His Gly Thr Cys Ile Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys 
65                  70                  75                  80  


Arg Ser Gly Trp Glu Gly Arg Phe Cys Gln Arg Glu Val Ser Phe Leu 
                85                  90                  95      


Asn Cys Ser Leu Asp Asn Gly Gly Cys Thr His Tyr Cys Leu Glu Glu 
            100                 105                 110         


Val Gly Trp Arg Arg Cys Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp 
        115                 120                 125             


Asp Leu Leu Gln Cys His Pro Ala Val Lys Phe Pro Cys Gly Arg Pro 
    130                 135                 140                 


Trp Lys Arg Met Glu Lys Lys Arg Ser His Leu Lys Arg Asp Thr Ala 
145                 150                 155                 160 


Asp Gln Glu Asp Gln Val Ala Pro Arg Leu Ile Asp Gly Lys Met Thr 
                165                 170                 175     


Arg Arg Gly Asp Ser Pro Trp Gln Val Val Leu Leu Asp Ser Lys Lys 
            180                 185                 190         


Lys Leu Ala Cys Gly Ala Val Leu Ile His Pro Ser Trp Val Leu Thr 
        195                 200                 205             


Ala Ala His Cys Met Asp Glu Ser Lys Lys Leu Leu Val Arg Leu Gly 
    210                 215                 220                 


Glu Tyr Asp Leu Arg Arg Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile 
225                 230                 235                 240 


Lys Glu Val Phe Val His Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn 
                245                 250                 255     


Asp Ile Ala Leu Leu His Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr 
            260                 265                 270         


Ile Val Pro Ile Cys Leu Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu 
        275                 280                 285             


Asn Gln Ala Gly Gln Glu Thr Leu Val Thr Gly Trp Gly Tyr His Ser 
    290                 295                 300                 


Ser Arg Glu Lys Glu Ala Lys Arg Asn Arg Thr Phe Val Leu Asn Phe 
305                 310                 315                 320 


Ile Lys Ile Pro Val Val Pro His Asn Glu Cys Ser Glu Val Met Ser 
                325                 330                 335     


Asn Met Val Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Arg 
            340                 345                 350         


Gln Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser Phe 
        355                 360                 365             


His Gly Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys 
    370                 375                 380                 


Gly Leu Leu His Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu 
385                 390                 395                 400 


Asp Trp Ile His Gly His Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser 
                405                 410                 415     


Trp Ala Pro 
            


<210>  9
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  9

Ile Asp Gly Arg Ile Val 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  10

Ile Asp Pro Arg Ile Val 
1               5       


<210>  11
<211>  46
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  11
cacagcagac caagaagacc aagtagctcc gcggctcatt gctggg                      46


<210>  12
<211>  46
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  12
cccagcaatg agccgcggag ctacttggtc ttcttggtct gctgtg                      46


<210>  13
<211>  34
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  13
tgcctgcgag ggcgacgctg gggggcccat ggtc                                   34


<210>  14
<211>  34
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SYNTHETIC SEQUENCE

<400>  14
gaccatgggc cccccagcgt cgccctcgca ggca                                   34


