                              Sequence Listing

<110> GENENTECH, INC. et al.
      

<120> COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND 
      TREATMENT OF TUMOR

<130> P5043R1-WO

<141> 2013-03-14

<150> US 61/646,803
<151> 2012-05-14

<150> US 61/776,603
<151> 2013-03-11

<160> 79

<210> 1
<211> 5615
<212> DNA
<213> Homo sapiens

<220>
<221> Unsure
<222> 429
<223> Unknown base

<400> 1
 gcttcagtcc cgcgaccgaa gcagggcgcg cagcagcgct gagtgccccg 50

 gaacgtgcgt cgcgccccca gtgtccgtcg cgtccgccgc gccccgggcg 100

 gggatggggc ggccagactg agcgccgcac ccgccatcca gacccgccgg 150

 ccctagccgc agtccctcca gccgtggccc cagcgcgcac gggcgatggc 200

 gaaggcgacg tccggtgccg cggggctgcg tctgctgttg ctgctgctgc 250

 tgccgctgct aggcaaagtg gcattgggcc tctacttctc gagggatgct 300

 tactgggaga agctgtatgt ggaccaggcg gccggcacgc ccttgctgta 350

 cgtccatgcc ctgcgggacg cccctgagga ggtgcccagc ttccgcctgg 400

 gccagcatct ctacggcacg taccgcacnc ggctgcatga gaacaactgg 450

 atctgcatcc aggaggacac cggcctcctc taccttaacc ggagcctgga 500

 ccatagctcc tgggagaagc tcagtgtccg caaccgcggc tttcccctgc 550

 tcaccgtcta cctcaaggtc ttcctgtcac ccacatccct tcgtgagggc 600

 gagtgccagt ggccaggctg tgcccgcgta tacttctcct tcttcaacac 650

 ctcctttcca gcctgcagct ccctcaagcc ccgggagctc tgcttcccag 700

 agacaaggcc ctccttccgc attcgggaga accgaccccc aggcaccttc 750

 caccagttcc gcctgctgcc tgtgcagttc ttgtgcccca acatcagcgt 800

 ggcctacagg ctcctggagg gtgagggtct gcccttccgc tgcgccccgg 850

 acagcctgga ggtgagcacg cgctgggccc tggaccgcga gcagcgggag 900

 aagtacgagc tggtggccgt gtgcaccgtg cacgccggcg cgcgcgagga 950

 ggtggtgatg gtgcccttcc cggtgaccgt gtacgacgag gacgactcgg 1000

 cgcccacctt ccccgcgggc gtcgacaccg ccagcgccgt ggtggagttc 1050

 aagcggaagg aggacaccgt ggtggccacg ctgcgtgtct tcgatgcaga 1100

 cgtggtacct gcatcagggg agctggtgag gcggtacaca agcacgctgc 1150

 tccccgggga cacctgggcc cagcagacct tccgggtgga acactggccc 1200

 aacgagacct cggtccaggc caacggcagc ttcgtgcggg cgaccgtaca 1250

 tgactatagg ctggttctca accggaacct ctccatctcg gagaaccgca 1300

 ccatgcagct ggcggtgctg gtcaatgact cagacttcca gggcccagga 1350

 gcgggcgtcc tcttgctcca cttcaacgtg tcggtgctgc cggtcagcct 1400

 gcacctgccc agtacctact ccctctccgt gagcaggagg gctcgccgat 1450

 ttgcccagat cgggaaagtc tgtgtggaaa actgccaggc gttcagtggc 1500

 atcaacgtcc agtacaagct gcattcctct ggtgccaact gcagcacgct 1550

 aggggtggtc acctcagccg aggacacctc ggggatcctg tttgtgaatg 1600

 acaccaaggc cctgcggcgg cccaagtgtg ccgaacttca ctacatggtg 1650

 gtggccaccg accagcagac ctctaggcag gcccaggccc agctgcttgt 1700

 aacagtggag gggtcatatg tggccgagga ggcgggctgc cccctgtcct 1750

 gtgcagtcag caagagacgg ctggagtgtg aggagtgtgg cggcctgggc 1800

 tccccaacag gcaggtgtga gtggaggcaa ggagatggca aagggatcac 1850

 caggaacttc tccacctgct ctcccagcac caagacctgc cccgacggcc 1900

 actgcgatgt tgtggagacc caagacatca acatttgccc tcaggactgc 1950

 ctccggggca gcattgttgg gggacacgag cctggggagc cccgggggat 2000

 taaagctggc tatggcacct gcaactgctt ccctgaggag gagaagtgct 2050

 tctgcgagcc cgaagacatc caggatccac tgtgcgacga gctgtgccgc 2100

 acggtgatcg cagccgctgt cctcttctcc ttcatcgtct cggtgctgct 2150

 gtctgccttc tgcatccact gctaccacaa gtttgcccac aagccaccca 2200

 tctcctcagc tgagatgacc ttccggaggc ccgcccaggc cttcccggtc 2250

 agctactcct cttccggtgc ccgccggccc tcgctggact ccatggagaa 2300

 ccaggtctcc gtggatgcct tcaagatcct ggaggatcca aagtgggaat 2350

 tccctcggaa gaacttggtt cttggaaaaa ctctaggaga aggcgaattt 2400

 ggaaaagtgg tcaaggcaac ggccttccat ctgaaaggca gagcagggta 2450

 caccacggtg gccgtgaaga tgctgaaaga gaacgcctcc ccgagtgagc 2500

 ttcgagacct gctgtcagag ttcaacgtcc tgaagcaggt caaccaccca 2550

 catgtcatca aattgtatgg ggcctgcagc caggatggcc cgctcctcct 2600

 catcgtggag tacgccaaat acggctccct gcggggcttc ctccgcgaga 2650

 gccgcaaagt ggggcctggc tacctgggca gtggaggcag ccgcaactcc 2700

 agctccctgg accacccgga tgagcgggcc ctcaccatgg gcgacctcat 2750

 ctcatttgcc tggcagatct cacaggggat gcagtatctg gccgagatga 2800

 agctcgttca tcgggacttg gcagccagaa acatcctggt agctgagggg 2850

 cggaagatga agatttcgga tttcggcttg tcccgagatg tttatgaaga 2900

 ggattcctac gtgaagagga gccagggtcg gattccagtt aaatggatgg 2950

 caattgaatc cctttttgat catatctaca ccacgcaaag tgatgtatgg 3000

 tcttttggtg tcctgctgtg ggagatcgtg accctagggg gaaaccccta 3050

 tcctgggatt cctcctgagc ggctcttcaa ccttctgaag accggccacc 3100

 ggatggagag gccagacaac tgcagcgagg agatgtaccg cctgatgctg 3150

 caatgctgga agcaggagcc ggacaaaagg ccggtgtttg cggacatcag 3200

 caaagacctg gagaagatga tggttaagag gagagactac ttggaccttg 3250

 cggcgtccac tccatctgac tccctgattt atgacgacgg cctctcagag 3300

 gaggagacac cgctggtgga ctgtaataat gcccccctcc ctcgagccct 3350

 cccttccaca tggattgaaa acaaactcta tggcatgtca gacccgaact 3400

 ggcctggaga gagtcctgta ccactcacga gagctgatgg cactaacact 3450

 gggtttccaa gatatccaaa tgatagtgta tatgctaact ggatgctttc 3500

 accctcagcg gcaaaattaa tggacacgtt tgatagttaa catttctttg 3550

 tgaaaggtaa tggactcaca aggggaagaa acatgctgag aatggaaagt 3600

 ctaccggccc tttctttgtg aacgtcacat tggccgagcc gtgttcagtt 3650

 cccaggtggc agactcgttt ttggtagttt gttttaactt ccaaggtggt 3700

 tttacttctg atagccggtg attttccctc ctagcagaca tgccacaccg 3750

 ggtaagagct ctgagtctta gtggttaagc attcctttct cttcagtgcc 3800

 cagcagcacc cagtgttggt ctgtgtccat cagtgaccac caacattctg 3850

 tgttcacatg tgtgggtcca acacttacta cctggtgtat gaaattggac 3900

 ctgaactgtt ggatttttct agttgccgcc aaacaaggca aaaaaattta 3950

 aacatgaagc acacacacaa aaaaggcagt aggaaaaatg ctggccctga 4000

 tgacctgtcc ttattcagaa tgagagactg cggggggggc ctgggggtag 4050

 tgtcaatgcc cctccagggc tggaggggaa gaggggcccc gaggatgggc 4100

 ctgggctcag cattcgagat cttgagaatg atttttttta aatcatgcaa 4150

 cctttcctta ggaagacatt tggttttcat catgattaag atgattccta 4200

 gatttagcac aatggagaga ttccatgcca tctttactat gtggatggtg 4250

 gtatcaggga agagggctca caagacacat ttgtcccccg ggcccaccac 4300

 atcatcctca cgtgttcggt actgagcagc cactacccct gatgagaaca 4350

 gtatgaagaa agggggctgt tggagtccca gaattgctga cagcagaggc 4400

 tttgctgctg tgaatcccac ctgccaccag cctgcagcac accccacagc 4450

 caagtagagg cgaaacgagt ggctcatcct acctgttagg agcaggtagg 4500

 gcttgtactc actttaattt gaatcttatc aacttactca taaagggaca 4550

 ggctagctag ctgtgtcaga agtagcaatg acaatgacca aggactgcta 4600

 cacctctgat tacaattctg atgtgaaaaa gatggtgttt ggctcttata 4650

 gagcctgtgt gaaaggccca tggatcagct cttcctgtgt ttgtaattta 4700

 atgctgctac aagatgtttc tgtttcttag attctgacca tgactcataa 4750

 gcttcttgtc attcttcatt gcttgtttgt ggtcacagat gcacaacact 4800

 cctccagtct tgtgggggca gcttttggga agtctcagca gctcttctgg 4850

 ctgtgttgtc agcactgtaa cttcgcagaa aagagtcgga ttaccaaaac 4900

 actgcctgct cttcagactt aaagcactga taggacttaa aatagtctca 4950

 ttcaaatact gtattttata taggcatttc acaaaaacag caaaattgtg 5000

 gcattttgtg aggccaaggc ttggatgcgt gtgtaataga gccttatggt 5050

 gtgtgcgcac acacccagag gagagtttga aaaatgctta ttggacacgt 5100

 aacctggctc taatttgggc tgtttttcag atacactgtg ataagttctt 5150

 ttacaaatat ctatagacat ggtaaacttt tggttttcag atatgcttaa 5200

 tgatagtctt actaaatgca gaaataagaa taaactttct caaattatta 5250

 aaaatgccta cacagtaagt gtgaattgct gcaacaggtt tgttctcagg 5300

 agggtaagaa ctccaggtct aaacagctga cccagtgatg gggaatttat 5350

 ccttgaccaa tttatccttg accaataacc taattgtcta ttcctgagtt 5400

 ataaaggtcc ccatccttat tagctctact ggaattttca tacacgtaaa 5450

 tgcagaagtt actaagtatt aagtattact gagtattaag tagtaatctg 5500

 tcagttatta aaatttgtaa aatctattta tgaaaggtca ttaaaccaga 5550

 tcatgttcct ttttttgtaa tcaaggtgac taagaaaatc agttgtgtaa 5600

 ataaaatcat  gtatc 5615

<210> 2
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 2
 Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu
   1               5                  10                  15

 Leu Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr
                  20                  25                  30

 Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala
                  35                  40                  45

 Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro
                  50                  55                  60

 Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr
                  65                  70                  75

 Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile Gln Glu
                  80                  85                  90

 Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser Ser
                  95                 100                 105

 Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr
                 110                 115                 120

 Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly
                 125                 130                 135

 Glu Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe
                 140                 145                 150

 Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu
                 155                 160                 165

 Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg
                 170                 175                 180

 Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe
                 185                 190                 195

 Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu
                 200                 205                 210

 Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser Thr
                 215                 220                 225

 Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
                 230                 235                 240

 Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met
                 245                 250                 255

 Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro
                 260                 265                 270

 Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe
                 275                 280                 285

 Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp
                 290                 295                 300

 Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr
                 305                 310                 315

 Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg
                 320                 325                 330

 Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser
                 335                 340                 345

 Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg
                 350                 355                 360

 Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu
                 365                 370                 375

 Val Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu
                 380                 385                 390

 Leu His Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro
                 395                 400                 405

 Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala
                 410                 415                 420

 Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly
                 425                 430                 435

 Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn Cys Ser
                 440                 445                 450

 Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile Leu
                 455                 460                 465

 Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
                 470                 475                 480

 Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln
                 485                 490                 495

 Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala
                 500                 505                 510

 Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg
                 515                 520                 525

 Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg
                 530                 535                 540

 Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe
                 545                 550                 555

 Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys
                 560                 565                 570

 Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys
                 575                 580                 585

 Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg
                 590                 595                 600

 Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu
                 605                 610                 615

 Glu Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys
                 620                 625                 630

 Asp Glu Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser
                 635                 640                 645

 Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys Ile His Cys Tyr
                 650                 655                 660

 His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala Glu Met Thr
                 665                 670                 675

 Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser
                 680                 685                 690

 Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val Ser
                 695                 700                 705

 Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
                 710                 715                 720

 Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe
                 725                 730                 735

 Gly Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala
                 740                 745                 750

 Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser
                 755                 760                 765

 Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys
                 770                 775                 780

 Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser
                 785                 790                 795

 Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly
                 800                 805                 810

 Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly
                 815                 820                 825

 Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His
                 830                 835                 840

 Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala
                 845                 850                 855

 Trp Gln Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu
                 860                 865                 870

 Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly
                 875                 880                 885

 Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr
                 890                 895                 900

 Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg Ile Pro Val
                 905                 910                 915

 Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr
                 920                 925                 930

 Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Val
                 935                 940                 945

 Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
                 950                 955                 960

 Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn
                 965                 970                 975

 Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln
                 980                 985                 990

 Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu
                 995                1000                1005

 Glu Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala
                1010                1015                1020

 Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu
                1025                1030                1035

 Glu Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro Arg
                1040                1045                1050

 Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly Met Ser
                1055                1060                1065

 Asp Pro Asn Trp Pro Gly Glu Ser Pro Val Pro Leu Thr Arg Ala
                1070                1075                1080

 Asp Gly Thr Asn Thr Gly Phe Pro Arg Tyr Pro Asn Asp Ser Val
                1085                1090                1095

 Tyr Ala Asn Trp Met Leu Ser Pro Ser Ala Ala Lys Leu Met Asp
                1100                1105                1110

 Thr Phe Asp Ser
                

<210> 3
<211> 1072
<212> PRT
<213> Homo sapiens

<400> 3
 Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu
   1               5                  10                  15

 Leu Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr
                  20                  25                  30

 Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala
                  35                  40                  45

 Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro
                  50                  55                  60

 Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr
                  65                  70                  75

 Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile Gln Glu
                  80                  85                  90

 Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser Ser
                  95                 100                 105

 Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr
                 110                 115                 120

 Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly
                 125                 130                 135

 Glu Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe
                 140                 145                 150

 Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu
                 155                 160                 165

 Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg
                 170                 175                 180

 Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe
                 185                 190                 195

 Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu
                 200                 205                 210

 Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser Thr
                 215                 220                 225

 Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
                 230                 235                 240

 Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met
                 245                 250                 255

 Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro
                 260                 265                 270

 Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe
                 275                 280                 285

 Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp
                 290                 295                 300

 Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr
                 305                 310                 315

 Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg
                 320                 325                 330

 Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser
                 335                 340                 345

 Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg
                 350                 355                 360

 Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu
                 365                 370                 375

 Val Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu
                 380                 385                 390

 Leu His Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro
                 395                 400                 405

 Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala
                 410                 415                 420

 Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly
                 425                 430                 435

 Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn Cys Ser
                 440                 445                 450

 Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile Leu
                 455                 460                 465

 Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
                 470                 475                 480

 Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln
                 485                 490                 495

 Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala
                 500                 505                 510

 Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg
                 515                 520                 525

 Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg
                 530                 535                 540

 Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe
                 545                 550                 555

 Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys
                 560                 565                 570

 Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys
                 575                 580                 585

 Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg
                 590                 595                 600

 Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu
                 605                 610                 615

 Glu Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys
                 620                 625                 630

 Asp Glu Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser
                 635                 640                 645

 Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys Ile His Cys Tyr
                 650                 655                 660

 His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala Glu Met Thr
                 665                 670                 675

 Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser
                 680                 685                 690

 Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val Ser
                 695                 700                 705

 Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
                 710                 715                 720

 Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe
                 725                 730                 735

 Gly Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala
                 740                 745                 750

 Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser
                 755                 760                 765

 Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys
                 770                 775                 780

 Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser
                 785                 790                 795

 Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly
                 800                 805                 810

 Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly
                 815                 820                 825

 Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His
                 830                 835                 840

 Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala
                 845                 850                 855

 Trp Gln Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu
                 860                 865                 870

 Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly
                 875                 880                 885

 Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr
                 890                 895                 900

 Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg Ile Pro Val
                 905                 910                 915

 Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr
                 920                 925                 930

 Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Val
                 935                 940                 945

 Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
                 950                 955                 960

 Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn
                 965                 970                 975

 Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln
                 980                 985                 990

 Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu
                 995                1000                1005

 Glu Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala
                1010                1015                1020

 Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu
                1025                1030                1035

 Glu Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro Arg
                1040                1045                1050

 Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly Arg Ile
                1055                1060                1065

 Ser His Ala Phe Thr Arg Phe
                1070        

<210> 4
<211> 15
<212> PRT
<213> Mus musculus

<400> 4
 Arg Ala Ser Glu Ser Val Asp Gly Tyr Gly Ser Ser Phe Met His
   1               5                  10                  15

<210> 5
<211> 10
<212> PRT
<213> Mus musculus

<400> 5
 Ser Ala Ser Ser Ser Val Thr Tyr Met Tyr
                   5                  10

<210> 6
<211> 11
<212> PRT
<213> Mus musculus

<400> 6
 Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala
                   5                  10    

<210> 7
<211> 11
<212> PRT
<213> Mus musculus

<400> 7
 Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser
                   5                  10    

<210> 8
<211> 11
<212> PRT
<213> Mus musculus

<400> 8
 Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala
                   5                  10    

<210> 9
<211> 16
<212> PRT
<213> Mus musculus

<400> 9
 Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu
   1               5                  10                  15

 His
    

<210> 10
<211> 16
<212> PRT
<213> Mus musculus

<400> 10
 Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Glu
    

<210> 11
<211> 7
<212> PRT
<213> Mus musculus

<400> 11
 Arg Thr Ser Asn Leu Glu Ser
                   5        

<210> 12
<211> 7
<212> PRT
<213> Mus musculus

<400> 12
 Leu Thr Ser Lys Leu Ala Ser
                   5        

<210> 13
<211> 7
<212> PRT
<213> Mus musculus

<400> 13
 Ser Gly Ser Thr Leu Gln Ser
                   5        

<210> 14
<211> 7
<212> PRT
<213> Mus musculus

<400> 14
 Ala Ala Ser Thr Leu Asp Ser
                   5        

<210> 15
<211> 7
<212> PRT
<213> Mus musculus

<400> 15
 Trp Gly Ser Thr Arg His Thr
                   5        

<210> 16
<211> 7
<212> PRT
<213> Mus musculus

<400> 16
 Lys Val Ser Asn Arg Phe Ser
                   5        

<210> 17
<211> 8
<212> PRT
<213> Mus musculus

<400> 17
 Gln Gln Asn Ser Glu Asp Arg Thr
                   5            

<210> 18
<211> 9
<212> PRT
<213> Mus musculus

<400> 18
 Gln Gln Trp Thr Gly Asn Pro Leu Thr
                   5                

<210> 19
<211> 9
<212> PRT
<213> Mus musculus

<400> 19
 Gln Gln His Asn Glu Tyr Pro Trp Thr
                   5                

<210> 20
<211> 9
<212> PRT
<213> Mus musculus

<400> 20
 Gln Gln Tyr Ile Glu Tyr Pro Trp Thr
                   5                

<210> 21
<211> 9
<212> PRT
<213> Mus musculus

<400> 21
 Leu Gln Tyr Ala Gly Asn Pro Phe Thr
                   5                

<210> 22
<211> 9
<212> PRT
<213> Mus musculus

<400> 22
 Gln Gln His Tyr Asn Ile Pro Trp Thr
                   5                

<210> 23
<211> 9
<212> PRT
<213> Mus musculus

<400> 23
 Ser Gln Ser Thr His Val Pro Phe Thr
                   5                

<210> 24
<211> 9
<212> PRT
<213> Mus musculus

<400> 24
 Phe Gln Gly Ser His Val Pro Pro Thr
                   5                

<210> 25
<211> 10
<212> PRT
<213> Mus musculus

<400> 25
 Gly Tyr Ser Phe Thr Gly Phe Thr Met Asn
                   5                  10

<210> 26
<211> 10
<212> PRT
<213> Mus musculus

<400> 26
 Gly Tyr Thr Phe Thr Thr Tyr Trp Met His
                   5                  10

<210> 27
<211> 11
<212> PRT
<213> Mus musculus

<400> 27
 Gly Tyr Ser Ile Thr Ser Asp Tyr Val Trp Asn
                   5                  10    

<210> 28
<211> 11
<212> PRT
<213> Mus musculus

<400> 28
 Gly Phe Ser Ile Thr Ser Asp Tyr Ala Trp Asn
                   5                  10    

<210> 29
<211> 11
<212> PRT
<213> Mus musculus

<400> 29
 Asp Ser Glu Val Phe Pro Ile Ala Tyr Met Ser
                   5                  10    

<210> 30
<211> 10
<212> PRT
<213> Mus musculus

<400> 30
 Gly Phe Thr Phe Ser Asn Tyr Trp Met Asn
                   5                  10

<210> 31
<211> 10
<212> PRT
<213> Mus musculus

<400> 31
 Gly Tyr Ile Phe Thr Thr Tyr Trp Met Asn
                   5                  10

<210> 32
<211> 10
<212> PRT
<213> Mus musculus

<400> 32
 Gly Phe Ser Leu Ser Arg Tyr Ser Val His
                   5                  10

<210> 33
<211> 18
<212> PRT
<213> Mus musculus

<400> 33
 Gly Leu Ile Asn Pro Tyr Asn Gly Val Thr Asn Tyr Asn Gln Lys
   1               5                  10                  15

 Phe Arg Gly
            

<210> 34
<211> 18
<212> PRT
<213> Mus musculus

<400> 34
 Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Ser Glu Tyr Asn Gln Lys
   1               5                  10                  15

 Phe Lys Asp
            

<210> 35
<211> 17
<212> PRT
<213> Mus musculus

<400> 35
 Gly Tyr Ile His Tyr Ser Gly Gly Thr Ser Tyr Asn Pro Ser Leu
   1               5                  10                  15

 Lys Ser
        

<210> 36
<211> 17
<212> PRT
<213> Mus musculus

<400> 36
 Ala Tyr Ile Thr Tyr Ser Gly Asp Thr Gly Tyr Asn Pro Ser Leu
   1               5                  10                  15

 Lys Ser
        

<210> 37
<211> 18
<212> PRT
<213> Mus musculus

<400> 37
 Gly Asp Ile Leu Pro Asn Ile Gly Arg Thr Ile Tyr Gly Glu Lys
   1               5                  10                  15

 Phe Glu Asp
            

<210> 38
<211> 20
<212> PRT
<213> Mus musculus

<400> 38
 Ala Asp Ile Ser Leu Lys Ser Asn Asn Tyr Gly Thr His Tyr Ala
   1               5                  10                  15

 Glu Ser Val Asn Gly
                  20

<210> 39
<211> 18
<212> PRT
<213> Mus musculus

<400> 39
 Gly Gln Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys
   1               5                  10                  15

 Phe Lys Gly
            

<210> 40
<211> 17
<212> PRT
<213> Mus musculus

<400> 40
 Gly Met Ile Trp Leu Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu
   1               5                  10                  15

 Lys Ser
        

<210> 41
<211> 10
<212> PRT
<213> Mus musculus

<400> 41
 Ala Arg His Tyr Ser Phe Ala Met Asp Tyr
                   5                  10

<210> 42
<211> 14
<212> PRT
<213> Mus musculus

<400> 42
 Ala Arg Trp Arg Phe Tyr Gly Ser Thr Tyr Gly Met Asp Tyr
                   5                  10                

<210> 43
<211> 11
<212> PRT
<213> Mus musculus

<400> 43
 Ala Arg Gly Asn Tyr Asp Trp Ala Phe Ala Tyr
                   5                  10    

<210> 44
<211> 11
<212> PRT
<213> Mus musculus

<400> 44
 Ala Arg Gly Asn Tyr Asp Trp Val Phe Ala Tyr
                   5                  10    

<210> 45
<211> 18
<212> PRT
<213> Mus musculus

<400> 45
 Gly Arg Ser Ile Thr Arg Ala Trp Phe Ala Tyr Trp Gly Gln Gly
   1               5                  10                  15

 Thr Ile Val
            

<210> 46
<211> 16
<212> PRT
<213> Mus musculus

<400> 46
 Ala Val Tyr Tyr Tyr Gly Val Lys Phe Tyr Tyr Phe Val Leu Gly
   1               5                  10                  15

 Tyr
    

<210> 47
<211> 5
<212> PRT
<213> Mus musculus

<400> 47
 Ala Met Leu Asp Tyr
                   5

<210> 48
<211> 11
<212> PRT
<213> Mus musculus

<400> 48
 Ala Arg Asn Leu Asp Ser Arg Gly Phe Ala His
                   5                  10    

<210> 49
<211> 128
<212> PRT
<213> Mus musculus

<400> 49
 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp
                  20                  25                  30

 Gly Tyr Gly Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Leu Ile Tyr Arg Thr Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Asn Ser Glu Asp Arg Thr Phe Gly Gly Gly Thr
                  95                 100                 105

 Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile
                 110                 115                 120

 Phe Pro Pro Ser Ser Glu Gln Leu
                 125            

<210> 50
<211> 124
<212> PRT
<213> Mus musculus

<400> 50
 Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Phe Pro
   1               5                  10                  15

 Gly Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Thr
                  20                  25                  30

 Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro
                  35                  40                  45

 Trp Ile Tyr Leu Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Thr
                  65                  70                  75

 Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp
                  80                  85                  90

 Thr Gly Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
                  95                 100                 105

 Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser
                 110                 115                 120

 Ser Glu Gln Leu
                

<210> 51
<211> 125
<212> PRT
<213> Mus musculus

<400> 51
 Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro
   1               5                  10                  15

 Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser
                  20                  25                  30

 Lys Tyr Leu Ala Trp Tyr Gln Asp Lys Pro Gly Lys Thr Asn Lys
                  35                  40                  45

 Leu Leu Ile Ser Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln
                  80                  85                  90

 His Asn Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
                  95                 100                 105

 Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
                 110                 115                 120

 Ser Ser Glu Gln Leu
                 125

<210> 52
<211> 125
<212> PRT
<213> Mus musculus

<400> 52
 Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro
   1               5                  10                  15

 Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser
                  20                  25                  30

 Lys Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Tyr Ile Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
                  95                 100                 105

 Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
                 110                 115                 120

 Ser Ser Glu Gln Leu
                 125

<210> 53
<211> 125
<212> PRT
<213> Mus musculus

<400> 53
 Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro
   1               5                  10                  15

 Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser
                  20                  25                  30

 Lys Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Tyr Ile Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
                  95                 100                 105

 Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
                 110                 115                 120

 Ser Ser Glu Gln Lys
                 125

<210> 54
<211> 125
<212> PRT
<213> Mus musculus

<400> 54
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu
   1               5                  10                  15

 Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser
                  20                  25                  30

 Gly Tyr Leu Ser Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys
                  35                  40                  45

 Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys
                  50                  55                  60

 Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Ala Ser Glu Asp Phe Ala Asp Tyr Phe Cys Leu Gln
                  80                  85                  90

 Tyr Ala Gly Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu
                  95                 100                 105

 Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
                 110                 115                 120

 Ser Ser Glu Gln Leu
                 125

<210> 55
<211> 125
<212> PRT
<213> Mus musculus

<400> 55
 Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Trp Gly Ser Thr Arg His Thr Gly Val Pro Asp
                  50                  55                  60

 Arg Phe Thr Gly Val Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                  65                  70                  75

 Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln
                  80                  85                  90

 His Tyr Asn Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
                  95                 100                 105

 Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
                 110                 115                 120

 Ser Ser Glu Gln Leu
                 125

<210> 56
<211> 143
<212> PRT
<213> Mus musculus

<400> 56
 Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu
   1               5                  10                  15

 Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro
                  35                  40                  45

 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val
                  80                  85                  90

 Tyr Phe Cys Ser Gln Ser Thr His Val Pro Phe Thr Phe Gly Ser
                  95                 100                 105

 Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val
                 110                 115                 120

 Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala
                 125                 130                 135

 Ser Val Val Cys Phe Leu Asn Asn
                 140            

<210> 57
<211> 130
<212> PRT
<213> Mus musculus

<400> 57
 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu
   1               5                  10                  15

 Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val
                  20                  25                  30

 His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro
                  35                  40                  45

 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Pro Thr Phe Gly Gly
                  95                 100                 105

 Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val
                 110                 115                 120

 Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu
                 125                 130

<210> 58
<211> 133
<212> PRT
<213> Mus musculus

<400> 58
 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly
   1               5                  10                  15

 Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr
                  20                  25                  30

 Gly Phe Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu
                  35                  40                  45

 Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Val Thr Asn Tyr
                  50                  55                  60

 Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Glu Ser
                  65                  70                  75

 Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Ala Arg His Tyr Ser Phe Ala Met Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr
                 110                 115                 120

 Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala
                 125                 130            

<210> 59
<211> 137
<212> PRT
<213> Mus musculus

<400> 59
 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly
   1               5                  10                  15

 Thr Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Thr Tyr Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Ser Glu Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Arg Ser
                  65                  70                  75

 Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Thr Val Tyr Tyr Cys Ala Arg Trp Arg Phe Tyr Gly Ser Thr
                  95                 100                 105

 Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
                 110                 115                 120

 Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly
                 125                 130                 135

 Ser Ala
        

<210> 60
<211> 157
<212> PRT
<213> Mus musculus

<400> 60
 Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Val Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Gly Tyr Ile His Tyr Ser Gly Gly Thr Ser Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu His Leu Asn Ser Leu Thr Thr Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Asn Tyr Asp Trp Ala Phe
                  95                 100                 105

 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys
                 110                 115                 120

 Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala
                 125                 130                 135

 Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
                 140                 145                 150

 Phe Pro Glu Pro Val Thr Val
                 155        

<210> 61
<211> 134
<212> PRT
<213> Mus musculus

<400> 61
 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Phe Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Ala Tyr Ile Thr Tyr Ser Gly Asp Thr Gly Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Val Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu Gln Leu Ser Ser Val Thr Thr Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Asn Tyr Asp Trp Val Phe
                  95                 100                 105

 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys
                 110                 115                 120

 Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala
                 125                 130                

<210> 62
<211> 134
<212> PRT
<213> Mus musculus

<400> 62
 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Phe Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Ala Tyr Ile Thr Tyr Ser Gly Asp Thr Gly Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Val Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu Gln Leu Ser Ser Val Thr Thr Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Asn Tyr Asp Trp Val Phe
                  95                 100                 105

 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys
                 110                 115                 120

 Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala
                 125                 130                

<210> 63
<211> 135
<212> PRT
<213> Mus musculus

<400> 63
 Gln Val His Leu Gln Gln Ser Gly Ser Glu Leu Arg Ser Pro Gly
   1               5                  10                  15

 Ser Ser Val Lys Leu Ser Cys Lys Asp Phe Asp Ser Glu Val Phe
                  20                  25                  30

 Pro Ile Ala Tyr Met Ser Trp Val Arg Gln Lys Pro Gly His Gly
                  35                  40                  45

 Phe Glu Trp Ile Gly Asp Ile Leu Pro Asn Ile Gly Arg Thr Ile
                  50                  55                  60

 Tyr Gly Glu Lys Phe Glu Asp Lys Ala Thr Leu Asp Ala Asp Thr
                  65                  70                  75

 Val Ser Asn Thr Ala Tyr Leu Glu Leu Asn Ser Leu Thr Ser Glu
                  80                  85                  90

 Asp Ser Ala Met Tyr Tyr Cys Gly Arg Ser Ile Thr Arg Ala Trp
                  95                 100                 105

 Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Val Ala
                 110                 115                 120

 Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala
                 125                 130                 135

<210> 64
<211> 141
<212> PRT
<213> Mus musculus

<400> 64
 Glu Val Asn Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Asp Ile Ser Leu Lys Ser Asn Asn Tyr Gly Thr
                  50                  55                  60

 His Tyr Ala Glu Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp
                  65                  70                  75

 Asp Ser Thr Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala
                  80                  85                  90

 Glu Asp Thr Gly Ile Tyr Tyr Cys Ala Val Tyr Tyr Tyr Gly Val
                  95                 100                 105

 Lys Phe Tyr Tyr Phe Val Leu Gly Tyr Trp Gly Gln Gly Thr Ser
                 110                 115                 120

 Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro
                 125                 130                 135

 Leu Ala Pro Gly Ser Ala
                 140    

<210> 65
<211> 151
<212> PRT
<213> Mus musculus

<400> 65
 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly
   1               5                  10                  15

 Ser Ser Val Lys Leu Ser Cys Arg Ala Ser Gly Tyr Ile Phe Thr
                  20                  25                  30

 Thr Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Gln Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser
                  65                  70                  75

 Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Ala Met Leu Asp Tyr Trp Gly Gln Gly
                  95                 100                 105

 Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val
                 110                 115                 120

 Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val
                 125                 130                 135

 Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr
                 140                 145                 150

 Val
    

<210> 66
<211> 156
<212> PRT
<213> Mus musculus

<400> 66
 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser
                  20                  25                  30

 Arg Tyr Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Leu Gly Met Ile Trp Leu Gly Gly Ser Thr Asp Tyr Asn
                  50                  55                  60

 Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ile Ser Lys
                  65                  70                  75

 Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr
                  80                  85                  90

 Ala Met Tyr Tyr Cys Ala Arg Asn Leu Asp Ser Arg Gly Phe Ala
                  95                 100                 105

 His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr
                 110                 115                 120

 Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln
                 125                 130                 135

 Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val
                 155    

<210> 67
<211> 6
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized CDR H1

<400> 67
 Ser Asp Tyr Val Trp Asn
                   5    

<210> 68
<211> 16
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized CDR H2

<400> 68
 Tyr Ile His Tyr Ser Gly Gly Thr Ser Tyr Asn Pro Ser Leu Lys
   1               5                  10                  15

 Ser
    

<210> 69
<211> 8
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized CDR H3

<400> 69
 Gly Asn Tyr Asp Trp Ala Ala Tyr
                   5            

<210> 70
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized CDR H3

<400> 70
 Gly Asn Tyr Asp Phe Ala Phe Ala Tyr
                   5                

<210> 71
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized CDR H3

<400> 71
 Gly Asn Tyr Asp His Ala Phe Ala Tyr
                   5                

<210> 72
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized CDR H3

<400> 72
 Gly Asn Tyr Asp Leu Ala Phe Ala Tyr
                   5                

<210> 73
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized CDR H3

<400> 73
 Gly Asn Tyr Asp Tyr Ala Phe Ala Tyr
                   5                

<210> 74
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized variable light chain

<400> 74
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser
                  20                  25                  30

 Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Asn Lys
                  35                  40                  45

 Leu Leu Ile Ser Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 His Asn Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys
        

<210> 75
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized variable heavy chain v.6

<400> 75
 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Val Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly
                  35                  40                  45

 Leu Glu Trp Ile Gly Tyr Ile His Tyr Ser Gly Gly Thr Ser Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asn Tyr Asp Trp Ala Phe
                  95                 100                 105

 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115            

<210> 76
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized variable heavy chain v.10

<400> 76
 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Val Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly
                  35                  40                  45

 Leu Glu Trp Ile Gly Tyr Ile His Tyr Ser Gly Gly Thr Ser Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asn Tyr Asp Phe Ala Phe
                  95                 100                 105

 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115            

<210> 77
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized variable heavy chain v.11

<400> 77
 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Val Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly
                  35                  40                  45

 Leu Glu Trp Ile Gly Tyr Ile His Tyr Ser Gly Gly Thr Ser Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asn Tyr Asp His Ala Phe
                  95                 100                 105

 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115            

<210> 78
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized variable heavy chain v.12

<400> 78
 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Val Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly
                  35                  40                  45

 Leu Glu Trp Ile Gly Tyr Ile His Tyr Ser Gly Gly Thr Ser Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asn Tyr Asp Leu Ala Phe
                  95                 100                 105

 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115            

<210> 79
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> Humanaized variable heavy chain v.13

<400> 79
 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Val Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly
                  35                  40                  45

 Leu Glu Trp Ile Gly Tyr Ile His Tyr Ser Gly Gly Thr Ser Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asn Tyr Asp Tyr Ala Phe
                  95                 100                 105

 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115            

