                         SEQUENCE LISTING

<110>  Genome Research Limited
 
<120>  Method for Genome Modification

<130>  16199.41

<150>  GB 1208845.6

<151>  18.05.2012

<150>  GB 1211961.6

<151>  05.07.2012

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  1
tgtgtccgtc gtggatctga                                                   20


<210>  2
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  2
caccaccttc ttgatgtcat catac                                             25


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-3'

<400>  3
tgccgcctgg agaaacctgc c                                                 21


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  4
acaagtcgga ggcttaatta cacat                                             25


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  5
ttgccattgc acaactcttt tc                                                22


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  6
ttctctggga aatcgtggaa atg                                               23


<210>  7
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  7
tgcatcggca ggatcca                                                      17


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  8
aacatttcct gtgctgtgct aca                                               23


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  9
cctgcaggtc tttgacgctc ggaa                                              24


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  10
tgccccttct ctgatggatt                                                   20


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  11
tgctcttgac tttgcttctg tga                                               23


<210>  12
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' - 3'

<400>  12
tgcgttgctc tggagataga agttattgtg gact                                   34


<210>  13
<211>  1318
<212>  DNA
<213>  unknown

<220>
<223>  97% to Adlercreutzia equolifaciens

<400>  13
acgggtgagt aacacgtgac caacctgccc cgcgctccgg gacaccgctg gaaacggcgg       60

ctaataccgg atactccggg agggccccat ggccctgccg ggaaagccga gacggcgcgg      120

gatggggtcg cggcccatta ggtagacggc ggggtaacgg cccaccgtgc ccgcgatggg      180

tagccggact gagaggtcga ccggccacat tgggactgag atacggccca gactcctacg      240

ggaggcagca gtggggaatt ttgcgcaatg gggggaaccc tgacgcagca acgccgcgtg      300

cgggacgaag gccctcgggt tgtaaaccgc tttcagcagg gaagatccaa gacggtacct      360

gcagaagaag ctccggctaa ctacgtgcca gcagccgcgg taatacgtag ggggcgagcg      420

ttatccggat tcattgggcg taaagcgcgc gtaggcggcc gcctaagcgg gacctctaac      480

cccggggctc aaccccgggc cgggtcccgg actgggcggc tcgagtgcgg tagaggagag      540

cggaattccc ggtgtagcgg tggaatgcgc agatatcggg aagaacaccg atggcgaagg      600

cagctctctg ggccgtcact gacgctgagg cgcgaaagct gggggagcga acaggattag      660

ataccctggt agtcccagcc gtaaacgatg ggcgctaggt gtggggggac gatccctccg      720

tgccgcagcc aacgcattaa gcgccccgcc tggggagtac ggccgcaagg ctaaaactca      780

aaggaattga cgggggcccg cacaagcagc ggagcatgtg gcttaattcg aagcaacgcg      840

aagaacctta ccagggcttg acatgccgat gaagccgggg agacccggtg gccgagagga      900

gtcggcgcag gtggtgcatg gctgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc      960

cgcaacgagc gcaacccccg ccccgtgttg ccagcattca gttggggact cgcgggggac     1020

tgccggcgtc aagccggagg aaggtgggga cgacgtcaag tcatcatgcc ccttatgccc     1080

tgggctgcac acgtgctaca atggccggta cagagggttg ccaccccgcg agggggagcg     1140

gatcccggaa agccggtccc agttcggatc gcaggctgca acccgcctgc gtgaagccgg     1200

agttgctagt aatcgcggat cagcacgccg cggtgaatac gttcccgggc cttgtacaca     1260

ccgcccgtca caccacccga gtcgtctgca cccgaagccg ccggccgaac ccccgggg       1318


<210>  14
<211>  1292
<212>  DNA
<213>  unknown

<220>
<223>  98% to Anaerostipes caccae

<400>  14
agtggcggac gggtgagtaa cgcgtgggga acctgcccta tacaggggga taacagctgg       60

aaacggctgc taataccgca taagcgcaca gaatcgcatg attcggtgtg aaaagctccg      120

gcagtatagg atggtcccgc gtctgattag ctggttggcg gggtaacggc ccaccaaggc      180

gacgatcagt agccggcttg agagagtgga cggccacatt gggactgaga cacggcccaa      240

actcctacgg gaggcagcag tggggaatat tgcacaatgg gggaaaccct gatgcagcga      300

cgccgcgtga gtgaagaagt atttcggtat gtaaagctct atcagcaggg aagaaaaaag      360

acggtacctg actaagaagc cccggctaac tacgtgccag cagccgcggt aatacgtagg      420

gggcaagcgt tatccggaat tactgggtgt aaagggtgcg taggtggcat ggtaagtcag      480

aagtgaaagc ccggggctta accccgggac tgcttttgaa actgtcatgc tggagtgcag      540

gagaggtaag cggaattcct agtgtagcgg tgaaatgcgt agatattagg aggaacacca      600

gtggcgaagg cggcttactg gactgtcact gacactgatg cacgaaagcg tggggagcaa      660

acaggattag ataccctggt agtccacgcc gtaaacgatg aatactaggt gtcggggccg      720

tagaggcttc ggtgccgcag caaacgcagt aagtattcca cctggggagt acgttcgcaa      780

gaatgaaact caaaggaatt gacggggacc cgcacaagcg gtggagcatg tggtttaatt      840

cgaagcaacg cgaagaacct tacctggtct tgacatctaa ctgaccggtt cgtaatggga      900

cctttccttc gggacagtta agacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag      960

atgttgggtt aagtcccgca acgagcgcaa cccctatctt tagtagccag catataaggt     1020

gggcactcta gagagactgc cagggataac ctggaggaag gtggggacga cgtcaaatca     1080

tcatgcccct tatggccagg gctacacacg tgctacaatg gcgtaaacaa agggaagcga     1140

agtcgtgagg cgaagcaaat cccagaaata acgtctcagt tcggattgta gtctgcaact     1200

cgactacatg aagctggaat cgctagtaat cgtgaatcag aatgtcacgg tgaatacgtt     1260

cccgggtctt gtacacaccg cccgtcacac ca                                   1292


<210>  15
<211>  1324
<212>  DNA
<213>  Staphylococcus warneri

<400>  15
agcggcggac gggtgagtaa cacgtggata acctacctat aagactggga taacttcggg       60

aaaccggagc taataccgga taacatattg aaccgcatgg ttcaatagtg aaaggcggct      120

ttgctgtcac ttatagatgg atccgcgccg tattagctag ttggtaaggt aacggcttac      180

caaggcaacg atacgtagcc gacctgagag ggtgatcggc cacactggaa ctgagacacg      240

gtccagactc ctacgggagg cagcagtagg gaatcttccg caatgggcga aagcctgacg      300

gagcaacgcc gcgtgagtga tgaaggtctt cggatcgtaa aactctgtta tcagggaaga      360

acaaatgtgt aagtaactgt gcacatcttg acggtacctg atcagaaagc cacggctaac      420

tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tatccggaat tattgggcgt      480

aaagcgcgcg taggcggttt tttaagtctg atgtgaaagc ccacggctca accgtggagg      540

gtcattggaa actggaaaac ttgagtgcag aagaggaaag tggaattcca tgtgtagcgg      600

tgaaatgcgc agagatatgg aggaacacca gtggcgaagg cgactttctg gtctgtaact      660

gacgctgatg tgcgaaagcg tggggatcaa acaggattag ataccctggt agtccacgcc      720

gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca gctaacgcat      780

taagcactcc gcctggggag tacgaccgca aggttgaaac tcaaaggaat tgacggggac      840

ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaaatc      900

ttgacatcct ttgaccgctc tagagataga gtcttcccct tcgggggaca aagtgacagg      960

tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg     1020

caacccttaa gcttagttgc catcattaag ttgggcactc taagttgact gccggtgaca     1080

aaccggagga aggtggggat gacgtcaaat catcatgccc cttatgattt gggctacaca     1140

cgtgctacaa tggacaatac aaagggcagc taaaccgcga ggtcaagcaa atcccataaa     1200

gttgttctca gttcggattg tagtctgcaa ctcgactaca tgaagctgga atcgctagta     1260

atcgtagatc agcatgctac ggtgaatacg ttcccgggtc ttgtacacac cgcccgtcac     1320

acca                                                                  1324


<210>  16
<211>  1323
<212>  DNA
<213>  Lactobacillus reuteri

<400>  16
agtggcggac gggtgagtaa cacgtaggta acctgccccg gagcggggga taacatttgg       60

aaacagatgc taataccgca taacaacaaa agccacatgg cttttgtttg aaagatggct      120

ttggctatca ctctgggatg gacctgcggt gcattagcta gttggtaagg taacggctta      180

ccaaggcgat gatgcatagc cgagttgaga gactgatcgg ccacaatgga actgagacac      240

ggtccatact cctacgggag gcagcagtag ggaatcttcc acaatgggcg caagcctgat      300

ggagcaacac cgcgtgagtg aagaagggtt tcggctcgta aagctctgtt gttggagaag      360

aacgtgcgtg agagtaactg ttcacgcagt gacggtatcc aaccagaaag tcacggctaa      420

ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg ttatccggat ttattgggcg      480

taaagcgagc gcaggcggtt gcttaggtct gatgtgaaag ccttcggctt aaccgaagaa      540

gtgcatcgga aaccgggcga cttgagtgca gaagaggaca gtggaactcc atgtgtagcg      600

gtggaatgcg tagatatatg gaagaacacc agtggcgaag gcggctgtct ggtctgcaac      660

tgacgctgag gctcgaaagc atgggtagcg aacaggatta gataccctgg tagtccatgc      720

cgtaaacgat gagtgctagg tgttggaggg tttccgccct tcagtgccgg agctaacgca      780

ttaagcactc cgcctgggga gtacgaccgc aaggttgaaa ctcaaaggaa ttgacggggg      840

cccgcacaag cggtggagca tgtggtttaa ttcgaagcta cgcgaagaac cttaccaggt      900

cttgacatct tgcgctaacc ttagagataa ggcgttccct tcggggacgc aatgacaggt      960

ggtgcatggt cgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc     1020

aacccttgtt actagttgcc agcattaagt tgggcactct agtgagactg ccggtgacaa     1080

accggaggaa ggtggggacg acgtcagatc atcatgcccc ttatgacctg ggctacacac     1140

gtgctacaat ggacggtaca acgagtcgca agctcgcgag agtaagctaa tctcttaaag     1200

ccgttctcag ttcggactgt aggctgcaac tcgcctacac gaagtcggaa tcgctagtaa     1260

tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca     1320

cca                                                                   1323


<210>  17
<211>  1323
<212>  DNA
<213>  Enterococcus hirae

<400>  17
agtggcgaac gggtgagtaa cacgtgggta acctgcccat cagaagggga taacacttgg       60

aaacaggtgc taataccgta taacaatcga aaccgcatgg tttcgatttg aaaggcgctt      120

tcgggtgtcg ctgatggatg gacccgcggt gcattagcta gttggtgagg taacggctca      180

ccaaggcgac gatgcatagc cgacctgaga gggtgatcgg ccacattggg actgagacac      240

ggcccaaact cctacgggag gcagcagtag ggaatcttcg gcaatggacg aaagtctgac      300

cgagcaacgc cgcgtgagtg aagaaggttt tcggatcgta aaactctgtt gttagagaag      360

aacaaggatg agagtaactg ttcatccctt gacggtatct aaccagaaag ccacggctaa      420

ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg ttgtccggat ttattgggcg      480

taaagcgagc gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag      540

ggtcattgga aactgggaga cttgagtgca gaagaggaga gtggaattcc atgtgtagcg      600

gtgaaatgcg tagatatatg gaggaacacc agtggcgaag gcggctctct ggtctgtaac      660

tgacgctgag gctcgaaagc gtggggagca aacaggatta gataccctgg tagtccacgc      720

cgtaaacgat gagtgctaag tgttggaggg tttccgccct tcagtgctgc agctaacgca      780

ttaagcactc cgcctgggga gtacgaccgc aaggttgaaa ctcaaaggaa ttgacggggg      840

cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt      900

cttgacatcc tttgaccact ctagagatag agcttcccct tcgggggcaa agtgacaggt      960

ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc     1020

aacccttatt gttagttgcc atcattcagt tgggcactct agcaagactg ccggtgacaa     1080

accggaggaa ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac     1140

gtgctacaat gggaagtaca acgagtcgca aagtcgcgag gctaagctaa tctcttaaag     1200

cttctctcag ttcggattgt aggctgcaac tcgcctacat gaagccggaa tcgctagtaa     1260

tcgcggatca gcacgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca     1320

cca                                                                   1323


<210>  18
<211>  1308
<212>  DNA
<213>  unknown

<220>
<223>  87% to Barnesiella intestinihominis

<400>  18
accggcgcac gggtgagtaa cacgtatgca acctgccctc ttcaggggga caaccttccg       60

aaagggaggc taatcccgcg tatatcggtt tcgggcatcc gttatcgagg aaagattcat      120

cggaagagga tgggcatgcg gcgcattagc ttgacggcgg ggtaacggcc caccgtggcg      180

acgatgcgta ggggttctga gaggaaggtc ccccacactg gtactgagac acggaccaga      240

ctcctacggg aggcagcagt gaggaatatt ggtcaatggg agagatcctg aaccagccaa      300

gccgcgtgag ggaagacggc cctatgggtt gtaaacctct tttgtcggag aacaaaaccc      360

gggacgagtc ccggactgcg tgtatccgaa gaaaaagcat cggctaactc cgtgccagca      420

gccgcggtaa tacggaggat gcgagcgtta tccggattta ttgggtttaa agggtgcgta      480

ggcggtccgt taagtcagcg gtaaaattgc ggggctcaac cccgtcgagc cgttgaaact      540

ggcagacttg agttggcgag aagtacgcgg aatgcgcggt gtagcggtga aatgcataga      600

tatcgcgcag aactccgatt gcgaaggcag cgtaccggcg ccagactgac gctgaggcac      660

gaaagcgtgg ggatcgaaca ggattagata ccctggtagt ccacgcagta aacgatgaat      720

gctaggtgtc cgggtcgaat gagacctggg cggcgaagcg aaagcgataa gcattccacc      780

tggggagtac gccggcaacg gtgaaactca aaggaattga cgggggcccg cacaagcgga      840

ggaacatgtg gtttaattcg atgatacgcg aggaacctta cccgggctca aacgggagtg      900

gaatggacca gagacggttc agcctacggg ccgcttccga ggtgctgcat ggttgtcgtc      960

agctcgtgcc gtgaggtgtc ggcttaagtg ccataacgag cgcaaccccc gccggcagtt     1020

gctaacgggc aatgccgagg actctgccgg gactgccgcc gcaaggcgtg aggaaggcgg     1080

ggatgacgtc aaatcagcac ggcccttacg tccggggcga cacacgtgtt acaatgggcg     1140

gtacagcggg aagccaggcg gcgacgccga gcggaacccg aaagccgttc tcagttcgga     1200

tcggagtctg caacccgact ccgtgaagct ggattcgcta gtaatcgcgc atcagccatg     1260

gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagcca                  1308


