                                   б

<110>  µϰ＼޹˾
 
<120>  Ƶĵס׺ＰӦ

<130>  DP1P130256ZX/CNQSL/ZJ

<150>  CN 201210157196.6
<151>  2012-05-18

<160>  203   

<170>  PatentIn version 3.5

<210>  1
<211>  191
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-1

<400>  1

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys 
        35                  40                  45              

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
    50                  55                  60                  

Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
65                  70                  75                  80  

Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
                85                  90                  95      

Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
            100                 105                 110         

Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
        115                 120                 125             

Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
    130                 135                 140                 

Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
145                 150                 155                 160 

Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
                165                 170                 175     

Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190     

<210>  2
<211>  196
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-2

<400>  2

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly 
        35                  40                  45              

Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
    50                  55                  60                  

Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
65                  70                  75                  80  

Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
                85                  90                  95      

Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
            100                 105                 110         

Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
        115                 120                 125             

Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
    130                 135                 140                 

Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
145                 150                 155                 160 

Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
                165                 170                 175     

Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
            180                 185                 190         

Gln Glu Asp Glu 
        195     

<210>  3
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-3

<400>  3

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  4
<211>  206
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-4

<400>  4

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met 
    50                  55                  60                  

Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg 
65                  70                  75                  80  

Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu 
                85                  90                  95      

Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu 
            100                 105                 110         

Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp 
        115                 120                 125             

Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu 
    130                 135                 140                 

Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly 
145                 150                 155                 160 

Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys 
                165                 170                 175     

Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp 
            180                 185                 190         

Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200                 205     

<210>  5
<211>  182
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-5

<400>  5

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Arg Pro 
            20                  25                  30          

Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val 
        35                  40                  45              

Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr 
    50                  55                  60                  

Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro 
65                  70                  75                  80  

Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys 
                85                  90                  95      

Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala 
            100                 105                 110         

Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe 
        115                 120                 125             

Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala 
    130                 135                 140                 

Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro 
145                 150                 155                 160 

Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe 
                165                 170                 175     

Tyr Phe Gln Glu Asp Glu 
            180         

<210>  6
<211>  185
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-6

<400>  6

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
        35                  40                  45              

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
    50                  55                  60                  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
65                  70                  75                  80  

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
                85                  90                  95      

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
            100                 105                 110         

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
        115                 120                 125             

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
    130                 135                 140                 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
145                 150                 155                 160 

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
                165                 170                 175     

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185 

<210>  7
<211>  190
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-7

<400>  7

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          

Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met 
        35                  40                  45              

Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg 
    50                  55                  60                  

Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu 
65                  70                  75                  80  

Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu 
                85                  90                  95      

Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp 
            100                 105                 110         

Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu 
        115                 120                 125             

Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly 
    130                 135                 140                 

Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys 
145                 150                 155                 160 

Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp 
                165                 170                 175     

Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190 

<210>  8
<211>  195
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-8

<400>  8

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg 
        35                  40                  45              

Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
    50                  55                  60                  

Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
65                  70                  75                  80  

Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro 
                85                  90                  95      

His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys 
            100                 105                 110         

Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile 
        115                 120                 125             

Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile 
    130                 135                 140                 

Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro 
145                 150                 155                 160 

Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu 
                165                 170                 175     

Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln 
            180                 185                 190         

Glu Asp Glu 
        195 

<210>  9
<211>  196
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-9

<220>
<221>  MOD_RES
<222>  (160)..(160)
<223>  S-ǰ-(CH2)4-NH- (N- (HOOC(CH2)14 
       CO)--Glu),Sǰװԭ

<400>  9

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly 
        35                  40                  45              

Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
    50                  55                  60                  

Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
65                  70                  75                  80  

Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
                85                  90                  95      

Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
            100                 105                 110         

Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
        115                 120                 125             

Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
    130                 135                 140                 

Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
145                 150                 155                 160 

Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
                165                 170                 175     

Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
            180                 185                 190         

Gln Glu Asp Glu 
        195     

<210>  10
<211>  196
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-10

<220>
<221>  MOD_RES
<222>  (128)..(128)
<223>  S-CH2-CONH-PEG20K,Sǰװԭ

<400>  10

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly 
        35                  40                  45              

Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
    50                  55                  60                  

Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
65                  70                  75                  80  

Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
                85                  90                  95      

Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
            100                 105                 110         

Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Cys 
        115                 120                 125             

Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
    130                 135                 140                 

Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser 
145                 150                 155                 160 

Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
                165                 170                 175     

Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
            180                 185                 190         

Gln Glu Asp Glu 
        195     

<210>  11
<211>  191
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-11

<220>
<221>  MOD_RES
<222>  (155)..(155)
<223>  S-CH2-CONH-PEG20K,Sǰװԭ

<400>  11

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          

Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys 
        35                  40                  45              

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
    50                  55                  60                  

Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
65                  70                  75                  80  

Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
                85                  90                  95      

Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
            100                 105                 110         

Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
        115                 120                 125             

Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
    130                 135                 140                 

Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
145                 150                 155                 160 

Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
                165                 170                 175     

Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190     

<210>  12
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-12

<220>
<221>  MOD_RES
<222>  (133)..(133)
<223>  S-ǰ-(CH2)4-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰװ
       ԭ

<400>  12

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  13
<211>  185
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-13

<220>
<221>  MOD_RES
<222>  (149)..(149)
<223>  S-ǰ-PEG20K,Sǰװԭ

<400>  13

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
        35                  40                  45              

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
    50                  55                  60                  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
65                  70                  75                  80  

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
                85                  90                  95      

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
            100                 105                 110         

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
        115                 120                 125             

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
    130                 135                 140                 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
145                 150                 155                 160 

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
                165                 170                 175     

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185 

<210>  14
<211>  185
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-14

<220>
<221>  MOD_RES
<222>  (117)..(117)
<223>  S-ǰ-(CH2)4-NH-(N-(HOOC(CH2)14 
       CO)--Glu),Sǰװԭ

<400>  14

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Gly Gly 
            20                  25                  30          

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
        35                  40                  45              

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
    50                  55                  60                  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
65                  70                  75                  80  

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
                85                  90                  95      

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
            100                 105                 110         

Leu Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
        115                 120                 125             

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
    130                 135                 140                 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
145                 150                 155                 160 

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
                165                 170                 175     

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185 

<210>  15
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-15

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  S-ǰ-(CH2)4-NH- (N-(HOOC(CH2)14 CO) 
       --Glu),Sǰװԭ

<400>  15

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Cys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  16
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-16

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  S-CH2-CONH-PEG20K,Sǰװԭ

<400>  16

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  17
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-17

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  S-ǰ-(CH2)4-NH-(N-(HOOC(CH2)14CO)-- 
       Glu),Sǰװԭ

<400>  17

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Cys Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  18
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-18

<400>  18

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Arg 
            20                  25                  30          

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
        35                  40                  45              

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
    50                  55                  60                  

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
65                  70                  75                  80  

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
                85                  90                  95      

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
            100                 105                 110         

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
        115                 120                 125             

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
    130                 135                 140                 

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
145                 150                 155                 160 

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
                165                 170                 175     

Phe Tyr Phe Gln Glu Asp Glu 
            180             

<210>  19
<211>  187
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-19

<400>  19

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe 
        35                  40                  45              

Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln 
    50                  55                  60                  

Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys 
65                  70                  75                  80  

Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His 
                85                  90                  95      

Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg 
            100                 105                 110         

Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys 
        115                 120                 125             

Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr 
    130                 135                 140                 

Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met 
145                 150                 155                 160 

Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val 
                165                 170                 175     

Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185         

<210>  20
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-20

<400>  20

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  21
<211>  197
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-21

<400>  21

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser 
        35                  40                  45              

Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn 
    50                  55                  60                  

Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu 
65                  70                  75                  80  

Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile 
                85                  90                  95      

Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu 
            100                 105                 110         

Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val 
        115                 120                 125             

Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala 
    130                 135                 140                 

Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala 
145                 150                 155                 160 

Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val 
                165                 170                 175     

Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr 
            180                 185                 190         

Phe Gln Glu Asp Glu 
        195         

<210>  22
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-22

<400>  22

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  23
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-23

<220>
<221>  MOD_RES
<222>  (147)..(147)
<223>  S-CH2-CONH-PEG20K,Sǰװԭ

<400>  23

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Arg 
            20                  25                  30          

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
        35                  40                  45              

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
    50                  55                  60                  

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
65                  70                  75                  80  

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
                85                  90                  95      

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
            100                 105                 110         

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
        115                 120                 125             

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
    130                 135                 140                 

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
145                 150                 155                 160 

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
                165                 170                 175     

Phe Tyr Phe Gln Glu Asp Glu 
            180             

<210>  24
<211>  187
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-24

<220>
<221>  MOD_RES
<222>  (151)..(151)
<223>  S-CH2-CONH-PEG20K,Sǰװԭ

<400>  24

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe 
        35                  40                  45              

Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln 
    50                  55                  60                  

Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys 
65                  70                  75                  80  

Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His 
                85                  90                  95      

Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg 
            100                 105                 110         

Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys 
        115                 120                 125             

Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr 
    130                 135                 140                 

Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met 
145                 150                 155                 160 

Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val 
                165                 170                 175     

Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185         

<210>  25
<211>  187
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-25

<220>
<221>  MOD_RES
<222>  (119)..(119)
<223>  S-ǰ-(CH2)4-NH- (N-(HOOC(CH2)14 
       CO)--Glu),Sǰװԭ

<400>  25

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe 
        35                  40                  45              

Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln 
    50                  55                  60                  

Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys 
65                  70                  75                  80  

Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His 
                85                  90                  95      

Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg 
            100                 105                 110         

Leu Gln Leu Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys 
        115                 120                 125             

Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr 
    130                 135                 140                 

Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met 
145                 150                 155                 160 

Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val 
                165                 170                 175     

Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185         

<210>  26
<211>  192
<212>  PRT
<213>  ˹ 

<220>
<223>  ںϵ G-26

<220>
<221>  MOD_RES
<222>  (156)..(156)
<223>  S-CH2-CONH-PEG20K,Sǰװԭ

<400>  26

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  27
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-27

<220>
<221>  MOD_RES
<222>  (124)..(124)
<223>  S-ǰ-(CH2)4-NH-(N-(HOOC(CH2)14 
       CO)--Glu),Sǰװԭ

<400>  27

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  


Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Cys Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  28
<211>  197
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-28

<220>
<221>  MOD_RES
<222>  (161)..(161)
<223>  S-CH2-CONH-PEG20K,Sǰװԭ

<400>  28

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser 
        35                  40                  45              


Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn 
    50                  55                  60                  

Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu 
65                  70                  75                  80  

Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile 
                85                  90                  95      

Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu 
            100                 105                 110         

Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val 
        115                 120                 125             

Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala 
    130                 135                 140                 

Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala 
145                 150                 155                 160 

Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val 
                165                 170                 175     

Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr 
            180                 185                 190         

Phe Gln Glu Asp Glu 
        195         

<210>  29
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-29

<220>
<221>  MOD_RES
<222>  (165)..(165)
<223>  S-ǰ-(CH2)4-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰװ
       ԭ

<400>  29

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  30
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-30

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  S-ǰ-(CH2)15-COOH,Sǰװԭ

<400>  30

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  31
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-31

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  S-ǰ-(CH2)17-COOH,Sǰװԭ

<400>  31

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  32
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-32

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰ
       װԭ

<400>  32

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  33
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-33

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N- 
       (HOOC(CH2)14CO)--Glu),Sǰװԭ

<400>  33

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Cys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  34
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-34

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14 
       CO)--Glu),Sǰװԭ

<400>  34

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Cys Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  35
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-35

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰ
       װԭ

<400>  35

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Cys 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  36
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-36

<220>
<221>  MOD_RES
<222>  (133)..(133)
<223>  S-ǰ-(CH2)15-COOH,Sǰװԭ

<400>  36

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  37
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-37

<220>
<221>  MOD_RES
<222>  (133)..(133)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO)-- 
       Glu),Sǰװԭ

<400>  37

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  38
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-38

<220>
<221>  MOD_RES
<222>  (165)..(165)

<400>  38

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  39
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-39

<220>
<221>  MOD_RES
<222>  (165)..(165)
<223>  S-CH2-CONH-(CH2CH2O)4-(CH2)2-NH-(N-(HOOC(CH2)16CO)--Glu),Sǰ
       װԭ

<400>  39

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  40
<211>  193
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-40

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  S-ǰ-(CH2)15-COOH,Sǰװԭ

<400>  40

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Cys Gly 
            20                  25                  30          

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
        35                  40                  45              

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
    50                  55                  60                  

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
65                  70                  75                  80  

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
                85                  90                  95      

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
            100                 105                 110         

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
        115                 120                 125             

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
    130                 135                 140                 

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp 
145                 150                 155                 160 

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
                165                 170                 175     

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
            180                 185                 190         

Glu 
 
<210>  41
<211>  193
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-41

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N- 
       (HOOC(CH2)14CO)--Glu),Sǰװԭ

<400>  41

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Cys Gly 
            20                  25                  30          

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
        35                  40                  45              

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
    50                  55                  60                  

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
65                  70                  75                  80  

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
                85                  90                  95      

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
            100                 105                 110         

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
        115                 120                 125             

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
    130                 135                 140                 

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp 
145                 150                 155                 160 

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
                165                 170                 175     

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
            180                 185                 190         

Glu 
    
<210>  42
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-42

<220>
<221>  MOD_RES
<222>  (124)..(124)
<223>  S-ǰ-(CH2)17-COOH,Sǰװԭ

<400>  42

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Cys Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  43
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-43

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰ
       װԭ

<400>  43

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Cys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  44
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-44

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰ
       װԭ

<400>  44

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      

Gln Ala Ala Cys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  45
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-45

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO--Glu-N- 
       -Glu),Sǰװԭ

<400>  45

His Gly Glu Gly Thr Phe Thr Ser Asp Cys Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  46
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-46

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰ
       װԭ

<400>  46

His Ala Glu Gly Thr Phe Thr Ser Asp Cys Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  47
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-47

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰ
       װԭ

<400>  47

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  48
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-48

<220>
<221>  MOD_RES
<222>  (124)..(124)
<223>  S-CH2-CONH-(CH2CH2O)4-(CH2)2-NH-(N-(HOOC(CH2)16CO)--Glu),Sǰ
       װԭ

<400>  48

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Cys Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  49
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-49

<220>
<221>  MOD_RES
<222>  (156)..(156)
<223>  S-ǰ-(CH2)15-COOH,Sǰװԭ

<400>  49

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  50
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-50

<220>
<221>  MOD_RES
<222>  (156)..(156)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N-(HOOC(CH2)14CO)--Glu),Sǰ
       װԭ

<400>  50

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gly 
            20                  25                  30          

Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser 
        35                  40                  45              

Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 
    50                  55                  60                  

Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val 
65                  70                  75                  80  

Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu 
                85                  90                  95      

Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser 
            100                 105                 110         

Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 
        115                 120                 125             

Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp 
    130                 135                 140                 

Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe 
145                 150                 155                 160 

Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met 
                165                 170                 175     

Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185                 190         

<210>  51
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-51

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶,Sǰװ
       ԭ,GLP-1϶ĵ SEQ ID 
       NO:185ͨĩ˰װϻǰӦӰ׽-1
       ׿ף

<400>  51

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  52
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-52

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶,Sǰװ
       ԭ,GLP-1϶ĵSEQ ID 
       NO:185ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  52

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  53
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-53

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶,Sǰװ
       ԭ,GLP-1϶ĵǣSEQ ID 
       NO:186ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  53

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  54
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-54

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:186ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  54

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  55
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-55

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵǣSEQ ID 
       NO:187ͨװϻǰӦӰ׽-1׿
       

<400>  55

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  56
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-56

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:187ͨװϻǰӦӰ׽-1׿
       

<400>  56

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  57
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-57

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵǣSEQ ID 
       NO:188ͨװϻǰӦӰ׽-1׿
       

<400>  57

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  58
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-58

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:188ͨװϻǰӦӰ׽-1׿
       

<400>  58

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  59
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-59

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG20K-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:185ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  59

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  60
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-60

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG20K-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:185ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  60

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  61
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-61

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG20K-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵǣSEQ ID 
       NO:189ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  61

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  62
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-62

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG20K-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:186ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  62

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  63
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-63

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG20K-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:187ͨװϻǰӦӰ׽-1׿
       

<400>  63

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  64
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-64

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG20K-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵǣSEQ ID 
       NO:190ͨװϻǰӦӰ׽-1׿
       

<400>  64

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  65
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-65

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG20K-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:188ͨװϻǰӦӰ׽-1׿
       

<400>  65

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  66
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-66

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG20K-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:188ͨװϻǰӦӰ׽-1׿
       

<400>  66

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  67
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-67

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  GLP-1϶-S-ǰ-PEG20K-ǰ-SSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:185ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  67

Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             

<210>  68
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-68

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PEG20K

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:185ͨĩ˰װϻǰӦӰ׽-1
       ׿ף

<400>  68

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  69
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-69

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PEG20K

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:186ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  69

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  70
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-70

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  GLP-1϶-S-ǰ-PEG20K-ǰ-SSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:189ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  70

Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             


<210>  71
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-71

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵǣSEQ ID 
       NO:191ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  71

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  72
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-72

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:191ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  72

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  73
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-73

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:189ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  73

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  74
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-74

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:189ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  74

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  75
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-75

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:190ͨװϻǰӦӰ׽-1׿
       

<400>  75

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  76
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-76

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:190ͨװϻǰӦӰ׽-1׿
       

<400>  76

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  77
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-77

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵǣSEQ ID 
       NO:192ͨװϻǰӦӰ׽-1׿
       

<400>  77

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  78
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-78

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:192ͨװϻǰӦӰ׽-1׿
       

<400>  78

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  79
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-79

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵǣSEQ ID 
       NO:193ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  79

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  80
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-80

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GLP-1϶ģSǰװ
       ԭӣGLP-1϶ĵSEQ ID 
       NO:193ͨĩ˰װϻǰӦӰ׽-1
       ׿

<400>  80

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  81
<211>  796
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-81

<400>  81

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
    50                  55                  60                  

Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
65                  70                  75                  80  

Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
                85                  90                  95      

Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
            100                 105                 110         

Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
        115                 120                 125             

Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
    130                 135                 140                 

Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
145                 150                 155                 160 

Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
                165                 170                 175     

His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
            180                 185                 190         

Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
        195                 200                 205             

Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
    210                 215                 220                 

Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
225                 230                 235                 240 

Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
                245                 250                 255     

Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
            260                 265                 270         

Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
        275                 280                 285             

Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
    290                 295                 300                 

Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
305                 310                 315                 320 

Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
                325                 330                 335     

His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
            340                 345                 350         

Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
        355                 360                 365             

Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
    370                 375                 380                 

Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
385                 390                 395                 400 

Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
                405                 410                 415     

Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
            420                 425                 430         

Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
        435                 440                 445             

Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
    450                 455                 460                 

Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
465                 470                 475                 480 

Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
                485                 490                 495     

Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
            500                 505                 510         

His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
        515                 520                 525             

Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
    530                 535                 540                 

Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
545                 550                 555                 560 

Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
                565                 570                 575     

Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
            580                 585                 590         

Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
        595                 600                 605             

Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
    610                 615                 620                 

Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
                645                 650                 655     

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
            660                 665                 670         

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
        675                 680                 685             

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
    690                 695                 700                 

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
705                 710                 715                 720 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
                725                 730                 735     

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
            740                 745                 750         

Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
        755                 760                 765             

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
    770                 775                 780                 

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
785                 790                 795     

<210>  82
<211>  796
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-82

<400>  82

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
    50                  55                  60                  

Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
65                  70                  75                  80  

Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
                85                  90                  95      

Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
            100                 105                 110         

Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
        115                 120                 125             

Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
    130                 135                 140                 

Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
145                 150                 155                 160 

Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
                165                 170                 175     

His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
            180                 185                 190         

Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
        195                 200                 205             

Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
    210                 215                 220                 

Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
225                 230                 235                 240 

Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
                245                 250                 255     

Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
            260                 265                 270         

Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
        275                 280                 285             

Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
    290                 295                 300                 

Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
305                 310                 315                 320 

Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
                325                 330                 335     

His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
            340                 345                 350         

Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
        355                 360                 365             

Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
    370                 375                 380                 

Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
385                 390                 395                 400 

Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
                405                 410                 415     

Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
            420                 425                 430         

Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
        435                 440                 445             

Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
    450                 455                 460                 

Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
465                 470                 475                 480 

Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
                485                 490                 495     

Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
            500                 505                 510         

His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
        515                 520                 525             

Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
    530                 535                 540                 

Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
545                 550                 555                 560 

Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
                565                 570                 575     

Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
            580                 585                 590         

Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
        595                 600                 605             

Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
    610                 615                 620                 

Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
                645                 650                 655     

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
            660                 665                 670         

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
        675                 680                 685             

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
    690                 695                 700                 

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
705                 710                 715                 720 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
                725                 730                 735     

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
            740                 745                 750         

Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
        755                 760                 765             

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
    770                 775                 780                 

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
785                 790                 795     

<210>  83
<211>  796
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-83

<400>  83

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             

Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
    210                 215                 220                 

Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
225                 230                 235                 240 

Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
                245                 250                 255     

Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
            260                 265                 270         

Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
        275                 280                 285             

Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
    290                 295                 300                 

Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
305                 310                 315                 320 

Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
                325                 330                 335     

Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
            340                 345                 350         

Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
        355                 360                 365             

Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
    370                 375                 380                 

Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
385                 390                 395                 400 

Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
                405                 410                 415     

Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
            420                 425                 430         

Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
        435                 440                 445             

Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
    450                 455                 460                 

Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
465                 470                 475                 480 

Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
                485                 490                 495     

Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
            500                 505                 510         

Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
        515                 520                 525             

Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
    530                 535                 540                 

Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
545                 550                 555                 560 

Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
                565                 570                 575     

Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
            580                 585                 590         

Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
        595                 600                 605             

Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
    610                 615                 620                 

Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
625                 630                 635                 640 

Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
                645                 650                 655     

Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
            660                 665                 670         

Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
        675                 680                 685             

Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
    690                 695                 700                 

Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
705                 710                 715                 720 

His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
                725                 730                 735     

Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
            740                 745                 750         

Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
        755                 760                 765             

Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
    770                 775                 780                 

Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
785                 790                 795     

<210>  84
<211>  796
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ G-84

<400>  84

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             

Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
    210                 215                 220                 

Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
225                 230                 235                 240 

Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
                245                 250                 255     

Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
            260                 265                 270         

Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
        275                 280                 285             

Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
    290                 295                 300                 

Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
305                 310                 315                 320 

Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
                325                 330                 335     

Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
            340                 345                 350         

Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
        355                 360                 365             

Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
    370                 375                 380                 

Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
385                 390                 395                 400 

Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
                405                 410                 415     

Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
            420                 425                 430         

Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
        435                 440                 445             

Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
    450                 455                 460                 

Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
465                 470                 475                 480 

Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
                485                 490                 495     

Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
            500                 505                 510         

Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
        515                 520                 525             

Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
    530                 535                 540                 

Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
545                 550                 555                 560 

Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
                565                 570                 575     

Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
            580                 585                 590         

Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
        595                 600                 605             

Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
    610                 615                 620                 

Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
625                 630                 635                 640 

Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
                645                 650                 655     

Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
            660                 665                 670         

Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
        675                 680                 685             

Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
    690                 695                 700                 

Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
705                 710                 715                 720 

His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
                725                 730                 735     

Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
            740                 745                 750         

Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
        755                 760                 765             

Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
    770                 775                 780                 

Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
785                 790                 795     

<210>  85
<211>  215
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-1

<400>  85

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg 
    50                  55                  60                  

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
65                  70                  75                  80  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
                85                  90                  95      

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
            100                 105                 110         

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
        115                 120                 125             

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
    130                 135                 140                 

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
145                 150                 155                 160 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
                165                 170                 175     

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
            180                 185                 190         

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
        195                 200                 205             

Phe Tyr Phe Gln Glu Asp Glu 
    210                 215 

<210>  86
<211>  215
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-2

<400>  86

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg 
    50                  55                  60                  

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
65                  70                  75                  80  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
                85                  90                  95      

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
            100                 105                 110         

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
        115                 120                 125             

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
    130                 135                 140                 

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
145                 150                 155                 160 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
                165                 170                 175     

Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
            180                 185                 190         

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
        195                 200                 205             

Phe Tyr Phe Gln Glu Asp Glu 
    210                 215 

<210>  87
<211>  215
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-3

<400>  87

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg 
    50                  55                  60                  

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
65                  70                  75                  80  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
                85                  90                  95      

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
            100                 105                 110         

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
        115                 120                 125             

Ser Leu Ser Ser Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
    130                 135                 140                 

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
145                 150                 155                 160 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
                165                 170                 175     

Ala Ala Ser Pro Gly Trp Phe Leu Ser Thr Ala Met Glu Ala Asp Gln 
            180                 185                 190         

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
        195                 200                 205             

Phe Tyr Phe Gln Glu Asp Glu 
    210                 215 

<210>  88
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-4

<400>  88

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
65                  70                  75                  80  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
        115                 120                 125             

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
    130                 135                 140                 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
145                 150                 155                 160 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
                165                 170                 175     

Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
            180                 185                 190         

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
        195                 200                 205             

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    210                 215                 220 

<210>  89
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-5

<400>  89

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
65                  70                  75                  80  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
        115                 120                 125             

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
    130                 135                 140                 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
145                 150                 155                 160 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
                165                 170                 175     

Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala 
            180                 185                 190         

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
        195                 200                 205             

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    210                 215                 220 

<210>  90
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-6

<400>  90

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
65                  70                  75                  80  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
        115                 120                 125             

His Gly Gly Lys Met Ser Leu Ser Ser Val Lys Ser Gly Asp Glu Thr 
    130                 135                 140                 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
145                 150                 155                 160 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
                165                 170                 175     

Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Ser Thr Ala 
            180                 185                 190         

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
        195                 200                 205             

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    210                 215                 220 

<210>  91
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-7

<400>  91

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
65                  70                  75                  80  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
                85                  90                  95      

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
            100                 105                 110         

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
        115                 120                 125             

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
    130                 135                 140                 

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
145                 150                 155                 160 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
                165                 170                 175     

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
            180                 185                 190         

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        195                 200                 205             

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
    210                 215                 220                 

Glu 
225 

<210>  92
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-8

<400>  92

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
65                  70                  75                  80  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
                85                  90                  95      

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
            100                 105                 110         

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
        115                 120                 125             

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
    130                 135                 140                 

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
145                 150                 155                 160 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
                165                 170                 175     

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp 
            180                 185                 190         

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        195                 200                 205             

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
    210                 215                 220                 

Glu 
225 

<210>  93
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-9

<400>  93

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
65                  70                  75                  80  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
                85                  90                  95      

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
            100                 105                 110         

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
        115                 120                 125             

Leu Phe Leu Gly Ile His Gly Gly Lys Met Ser Leu Ser Ser Val Lys 
    130                 135                 140                 

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
145                 150                 155                 160 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
                165                 170                 175     

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp 
            180                 185                 190         

Phe Leu Ser Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        195                 200                 205             

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
    210                 215                 220                 

Glu 
225 

<210>  94
<211>  230
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-10

<400>  94

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro 
65                  70                  75                  80  

Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val 
                85                  90                  95      

Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr 
            100                 105                 110         

Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro 
        115                 120                 125             

Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys 
    130                 135                 140                 

Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala 
145                 150                 155                 160 

Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe 
                165                 170                 175     

Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala 
            180                 185                 190         

Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro 
        195                 200                 205             

Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe 
    210                 215                 220                 

Tyr Phe Gln Glu Asp Glu 
225                 230 

<210>  95
<211>  230
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-11

<400>  95

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro 
65                  70                  75                  80  

Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val 
                85                  90                  95      

Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr 
            100                 105                 110         

Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro 
        115                 120                 125             

Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys 
    130                 135                 140                 

Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala 
145                 150                 155                 160 

Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe 
                165                 170                 175     

Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala 
            180                 185                 190         

Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro 
        195                 200                 205             

Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe 
    210                 215                 220                 

Tyr Phe Gln Glu Asp Glu 
225                 230 

<210>  96
<211>  230
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-12

<400>  96

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro 
65                  70                  75                  80  

Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val 
                85                  90                  95      

Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr 
            100                 105                 110         

Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro 
        115                 120                 125             

Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Ser 
    130                 135                 140                 

Leu Ser Ser Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala 
145                 150                 155                 160 

Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe 
                165                 170                 175     

Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala 
            180                 185                 190         

Ala Ser Pro Gly Trp Phe Leu Ser Thr Ala Met Glu Ala Asp Gln Pro 
        195                 200                 205             

Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe 
    210                 215                 220                 

Tyr Phe Gln Glu Asp Glu 
225                 230 

<210>  97
<211>  210
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-13

<400>  97

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg Pro Ser Gly Arg Lys 
    50                  55                  60                  

Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr 
65                  70                  75                  80  

Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro 
                85                  90                  95      

Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His 
            100                 105                 110         

Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val 
        115                 120                 125             

Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr 
    130                 135                 140                 

Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg 
145                 150                 155                 160 

Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly 
                165                 170                 175     

Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr 
            180                 185                 190         

Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu 
        195                 200                 205             

Asp Glu 
    210 

<210>  98
<211>  210
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-14

<400>  98

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg Pro Ser Gly Arg Lys 
    50                  55                  60                  

Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr 
65                  70                  75                  80  

Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro 
                85                  90                  95      

Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His 
            100                 105                 110         

Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val 
        115                 120                 125             

Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr 
    130                 135                 140                 

Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg 
145                 150                 155                 160 

Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly 
                165                 170                 175     

Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr 
            180                 185                 190         

Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu 
        195                 200                 205             

Asp Glu 
    210 

<210>  99
<211>  210
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-15

<400>  99

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg Pro Ser Gly Arg Lys 
    50                  55                  60                  

Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr 
65                  70                  75                  80  

Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro 
                85                  90                  95      

Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His 
            100                 105                 110         

Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Ser Leu Ser Ser Val 
        115                 120                 125             

Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr 
    130                 135                 140                 

Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg 
145                 150                 155                 160 

Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly 
                165                 170                 175     

Trp Phe Leu Ser Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr 
            180                 185                 190         

Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu 
        195                 200                 205             

Asp Glu 
    210 

<210>  100
<211>  215
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-16

<400>  100

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Arg 
    50                  55                  60                  

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
65                  70                  75                  80  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
                85                  90                  95      

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
            100                 105                 110         

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
        115                 120                 125             

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
    130                 135                 140                 

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
145                 150                 155                 160 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
                165                 170                 175     

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
            180                 185                 190         

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
        195                 200                 205             

Phe Tyr Phe Gln Glu Asp Glu 
    210                 215 

<210>  101
<211>  215
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-17

<400>  101

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Arg 
    50                  55                  60                  

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
65                  70                  75                  80  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
                85                  90                  95      

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
            100                 105                 110         

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
        115                 120                 125             

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
    130                 135                 140                 

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
145                 150                 155                 160 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
                165                 170                 175     

Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
            180                 185                 190         

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
        195                 200                 205             

Phe Tyr Phe Gln Glu Asp Glu 
    210                 215 

<210>  102
<211>  215
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-18

<400>  102

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Arg 
    50                  55                  60                  

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
65                  70                  75                  80  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
                85                  90                  95      

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
            100                 105                 110         

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
        115                 120                 125             

Ser Leu Ser Ser Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
    130                 135                 140                 

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
145                 150                 155                 160 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
                165                 170                 175     

Ala Ala Ser Pro Gly Trp Phe Leu Ser Thr Ala Met Glu Ala Asp Gln 
            180                 185                 190         

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
        195                 200                 205             

Phe Tyr Phe Gln Glu Asp Glu 
    210                 215 

<210>  103
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-19

<400>  103

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
65                  70                  75                  80  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
        115                 120                 125             

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
    130                 135                 140                 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
145                 150                 155                 160 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
                165                 170                 175     

Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
            180                 185                 190         

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
        195                 200                 205             

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    210                 215                 220 

<210>  104
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-20

<400>  104

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
65                  70                  75                  80  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
        115                 120                 125             

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
    130                 135                 140                 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
145                 150                 155                 160 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
                165                 170                 175     

Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala 
            180                 185                 190         

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
        195                 200                 205             

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    210                 215                 220 

<210>  105
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-21

<400>  105

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
65                  70                  75                  80  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
        115                 120                 125             

His Gly Gly Lys Met Ser Leu Ser Ser Val Lys Ser Gly Asp Glu Thr 
    130                 135                 140                 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
145                 150                 155                 160 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
                165                 170                 175     

Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Ser Thr Ala 
            180                 185                 190         

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
        195                 200                 205             

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    210                 215                 220 

<210>  106
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-22

<400>  106

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
65                  70                  75                  80  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
                85                  90                  95      

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
            100                 105                 110         

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
        115                 120                 125             

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
    130                 135                 140                 

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
145                 150                 155                 160 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
                165                 170                 175     

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
            180                 185                 190         

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        195                 200                 205             

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
    210                 215                 220                 

Glu 
225 

<210>  107
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-23

<400>  107

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
65                  70                  75                  80  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
                85                  90                  95      

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
            100                 105                 110         

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
        115                 120                 125             

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
    130                 135                 140                 

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
145                 150                 155                 160 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
                165                 170                 175     

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp 
            180                 185                 190         

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        195                 200                 205             

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
    210                 215                 220                 

Glu 
225 

<210>  108
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-24

<400>  108

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
65                  70                  75                  80  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
                85                  90                  95      

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
            100                 105                 110         

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
        115                 120                 125             

Leu Phe Leu Gly Ile His Gly Gly Lys Met Ser Leu Ser Ser Val Lys 
    130                 135                 140                 

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
145                 150                 155                 160 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
                165                 170                 175     

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp 
            180                 185                 190         

Phe Leu Ser Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        195                 200                 205             

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
    210                 215                 220                 

Glu 
225 

<210>  109
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-25

<220>
<221>  MOD_RES
<222>  (189)..(189)
<223>  S-ǰ-(CH2)4-NH-(N-(HOOC(CH2)14CO)--Glu)Sǰװ
       ԭ

<400>  109

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
65                  70                  75                  80  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
                85                  90                  95      

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
            100                 105                 110         

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
        115                 120                 125             

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
    130                 135                 140                 

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
145                 150                 155                 160 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
                165                 170                 175     

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
            180                 185                 190         

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        195                 200                 205             

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
    210                 215                 220                 

Glu 
225 

<210>  110
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-26

<220>
<221>  MOD_RES
<222>  (157)..(157)
<223>  S-CH2-CONH-(CH2CH2O)2-(CH2)2-NH-(N- 
       (HOOC(CH2)14CO)--Glu)Sǰװԭ

<400>  110

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
65                  70                  75                  80  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
                85                  90                  95      

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
            100                 105                 110         

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
        115                 120                 125             

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
    130                 135                 140                 

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Cys Ile Thr Asp 
145                 150                 155                 160 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
                165                 170                 175     

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp 
            180                 185                 190         

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        195                 200                 205             

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
    210                 215                 220                 

Glu 
225 

<210>  111
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-27

<220>
<221>  MOD_RES
<222>  (184)..(184)
<223>  S-CH2-CONH-PEG20KSǰװԭ

<400>  111

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
65                  70                  75                  80  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
        115                 120                 125             

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
    130                 135                 140                 

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
145                 150                 155                 160 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
                165                 170                 175     

Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
            180                 185                 190         

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
        195                 200                 205             

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    210                 215                 220 

<210>  112
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-28

<220>
<221>  MOD_RES
<222>  (152)..(152)
<223>  S-ǰ-(CH2)15- COOHSǰװԭ

<400>  112

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
65                  70                  75                  80  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
        115                 120                 125             

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
    130                 135                 140                 

Arg Leu Gln Leu Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg 
145                 150                 155                 160 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
                165                 170                 175     

Thr Ser Phe Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala 
            180                 185                 190         

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
        195                 200                 205             

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    210                 215                 220 

<210>  113
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-29

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-PEG12-ǰ-IL-1raIL-1raΪSEQ ID 
       NO:194ӻǰ-PEG12-NHSN-ǻǰȵ
       ϶İӦǰSEQ ID NO:194116λİװϻӦ

<400>  113

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Lys 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  114
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-30

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-PEG12-ǰ-׽-1׿ףа׽-1׿
       ׵ΪSEQ ID NO:195ӻǰ-PEG12-NHSN-ǻǰȵ
       ϶İӦǰSEQ ID 
       

<400>  114

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Lys 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  115
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-31

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-PEG20K-ǰ-IL-1raIL-1raΪSEQ ID 
       NO:194ӻǰ-PEG20K-NHSN-ǻǰȵ
       ϶İӦǰSEQ ID 
       NO:194116λİװϻӦ

<400>  115

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Lys 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  116
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-32

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-PEG20K-ǰ-׽-1׿ףа׽-1׿
       ׵ΪSEQ ID 
       NO:195ӻǰ-PEG20K-NHSN-ǻǰȵ
       ϶İӦǰSEQ ID 
       
<400>  116

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Lys 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  117
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-33

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-(N-(HOOC(CH2)14CO)--L-Glu)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-PEG12-ǰ-IL-1raIL-1raΪSEQ ID 
       NO:194ӻǰ-PEG12-NHSN-ǻǰȵ
       ϶İӦǰSE ID 
       NO:194116λİװϻӦ

<400>  117

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Lys 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  118
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-34

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-(N-(HOOC(CH2)16CO)--L-Glu)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-PEG12-ǰ-׽-1׿ףа׽-1׿
       ׵ΪSEQ ID 
       NO:195ӻǰ-PEG12-NHSN-ǻǰȵ
       ϶İӦǰSEQ ID 
    
<400>  118

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Lys 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  119
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-35

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG12-ȵأSǰװԭ

<400>  119

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  120
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-36

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG12-ȵ϶ģSǰװԭ

<400>  120

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  121
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-37

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG20K-ȵأSǰװԭ

<400>  121

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  122
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-38

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG 12 -ȵأSǰװԭ

<400>  122

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  123
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-39

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG 20K-ȵأSǰװԭ

<400>  123

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  124
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-40

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG12 -ȵ϶ģSǰװԭ

<400>  124

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  125
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-41

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG12-ȵdesB30T,Sǰװԭ

<400>  125

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  126
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-42

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG20K-ȵdesB30TSǰװԭ

<400>  126

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  127
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-43

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG 12-ȵdesB30TSǰװԭ

<400>  127

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  128
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-44

<220>
<221>  MOD_RES
<222>  (84)..(84)
<223>  S-ǰ-PEG 20K-ȵdesB30TSǰװԭ

<400>  128

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  129
<211>  64
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-45

<220>
<221>  MOD_RES
<222>  (64)..(64)
<223>  N-PEG12-ǰ-IL-1raIL-1raSEQ ID NO:194

<400>  129

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Lys 
    50                  55                  60                  

<210>  130
<211>  64
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-46

<220>
<221>  MOD_RES
<222>  (64)..(64)
<223>  N-PEG20K-ǰ-IL-1raIL-1raǣSEQ ID NO:194

<400>  130

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Lys 
    50                  55                  60                  

<210>  131
<211>  64
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-47

<220>
<221>  MOD_RES
<222>  (64)..(64)
<223>  N-PEG12-ǰ-׽-1׿ף׽-1׿׵
       ǣSEQ ID NO:195

<400>  131

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Lys 
    50                  55                  60                  

<210>  132
<211>  64
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-48

<220>
<221>  MOD_RES
<222>  (64)..(64)
<223>  N-PEG20K-ǰ-׽-1׿ף׽-1׿׵
       ǣSEQ ID NO:195

<400>  132

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Lys 
    50                  55                  60                  

<210>  133
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-49

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-PEG12-ǰ-IL-1raIL-1raSEQ ID NO:196

<400>  133

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  134
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-50

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-PEG20K-ǰ- IL-1raIL-1raǣSEQ ID NO:196

<400>  134

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  135
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-51

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-PEG12-ǰ-׽-1׿ף׽-1׿׵
       ǣSEQ ID NO:196

<400>  135

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Lys 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  136
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-52

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-PEG20K-ǰ-׽-1׿ף׽-1׿׵
       ǣSEQ ID NO:196

<400>  136

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Lys 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  137
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-53

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  N-PEG12-ǰ-׽-1׿ף׽-1׿׵
       ǣSEQ ID NO:196

<400>  137

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Lys Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  138
<211>  63
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-54

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  N-PEG20K-ǰ-׽-1׿ף׽-1׿׵
       ǣSEQ ID NO:196

<400>  138

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Lys Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  60              

<210>  139
<211>  58
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-55

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  N-PEG12-ǰ-IL-1raIL-1raΪSEQ ID NO:194

<400>  139

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Lys Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55              

<210>  140
<211>  58
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-56

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  N-PEG12-ǰ-׽-1׿ף׽-1׿׵
       ΪSEQ ID NO:195

<400>  140

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Gly Ser Gly Ser Ser Ser Ala 
            20                  25                  30          

Lys Ala Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
        35                  40                  45              

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55              

<210>  141
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-57

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  S-ǰ-PEG12-ȵأSǰװԭ

<400>  141

Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             

<210>  142
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-58

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  S-ǰ-PEG12-ȵ϶,Sǰװԭ

<400>  142

Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             

<210>  143
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-59

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  S-ǰ-PEG12-ȵdesB30TSǰװԭ

<400>  143

Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             

<210>  144
<211>  154
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-60

<220>
<221>  MOD_RES
<222>  (154)..(154)
<223>  S-ǰ-PEG12-ȵأSǰװԭ

<400>  144

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu Cys 
145                 150                 

<210>  145
<211>  154
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-61

<220>
<221>  MOD_RES
<222>  (154)..(154)
<223>  S-ǰ-PEG12-ȵdesB30TSǰװԭ

<400>  145

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu Cys 
145                 150                 

<210>  146
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-62

<400>  146

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 

Gly Ser Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala 
                165                 170                 175     

Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            180                 185                 190         

Gly Ser Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu 
        195                 200                 205             

Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
    210                 215                 220                 

Asn 
225 

<210>  147
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-63

<400>  147

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 

Gly Ser Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala 
                165                 170                 175     

Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            180                 185                 190         

Gly Ser Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu 
        195                 200                 205             

Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
    210                 215                 220                 

Asn 
225 

<210>  148
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-64

<400>  148

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Ser Leu Ser Ser Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Ser Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 

Gly Ser Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala 
                165                 170                 175     

Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            180                 185                 190         

Gly Ser Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu 
        195                 200                 205             

Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
    210                 215                 220                 

Asn 
225 

<210>  149
<211>  225
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-65

<400>  149

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 

Gly Ser Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala 
                165                 170                 175     

Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            180                 185                 190         

Gly Ser Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu 
        195                 200                 205             

Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
    210                 215                 220                 

Asn 
225 

<210>  150
<211>  232
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-66

<400>  150

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Cys Gly 
145                 150                 155                 160 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Val Asn Gln His Leu Cys 
                165                 170                 175     

Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 
            180                 185                 190         

Phe Phe Tyr Thr Pro Lys Thr Gly Ser Gly Ser Ser Ser Ala Ala Ala 
        195                 200                 205             

Pro Gln Thr Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu 
    210                 215                 220                 

Tyr Gln Leu Glu Asn Tyr Cys Asn 
225                 230         

<210>  151
<211>  231
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-67

<400>  151

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ser 
            20                  25                  30          

Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val Glu Gln Cys 
        35                  40                  45              

Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Gly 
    50                  55                  60                  

Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Gly Gly Gly Gly Ser Arg 
65                  70                  75                  80  

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
                85                  90                  95      

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
            100                 105                 110         

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
        115                 120                 125             

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
    130                 135                 140                 

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
145                 150                 155                 160 

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
                165                 170                 175     

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
            180                 185                 190         

Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
        195                 200                 205             

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
    210                 215                 220                 

Phe Tyr Phe Gln Glu Asp Glu 
225                 230     

<210>  152
<211>  820
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-68

<400>  152

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      

Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          

Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              

Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  

Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  

Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      

Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         

Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             

Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 

Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 

Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     

Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         

Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             

Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 

Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 

Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     

Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         

Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             

Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 

Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 

Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     

Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         

Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             

Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 

Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 

Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     

Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         

Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             

Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 

Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 

Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     

Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         

Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             

Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 

Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 

Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     

Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         

Gly Gly Ser Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu 
        595                 600                 605             

Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
    610                 615                 620                 

Thr Gly Ser Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly Ile Val 
625                 630                 635                 640 

Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr 
                645                 650                 655     

Cys Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly 
            660                 665                 670         

Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        675                 680                 685             

Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    690                 695                 700                 

Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
705                 710                 715                 720 

Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                725                 730                 735     

Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            740                 745                 750         

Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        755                 760                 765             

Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    770                 775                 780                 

Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
785                 790                 795                 800 

Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                805                 810                 815     

Gln Glu Asp Glu 
            820 

<210>  153
<211>  820
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-69

<400>  153

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      

Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          

Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              

Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  

Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  

Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      

Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         

Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             

Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 

Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 

Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     

Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         

Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             

Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 

Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 

Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     

Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         

Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             

Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 

Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 

Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     

Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         

Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             

Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 

Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 

Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     

Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         

Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             

Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 

Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 

Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     

Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         

Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             

Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 

Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 

Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     

Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         

Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe 
        595                 600                 605             

Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln 
    610                 615                 620                 

Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys 
625                 630                 635                 640 

Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His 
                645                 650                 655     

Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg 
            660                 665                 670         

Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys 
        675                 680                 685             

Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr 
    690                 695                 700                 

Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met 
705                 710                 715                 720 

Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val 
                725                 730                 735     

Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser 
            740                 745                 750         

Gly Gly Gly Gly Ser Phe Val Asn Gln His Leu Cys Gly Ser His Leu 
        755                 760                 765             

Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr 
    770                 775                 780                 

Pro Lys Thr Gly Ser Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr Gly 
785                 790                 795                 800 

Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
                805                 810                 815     

Asn Tyr Cys Asn 
            820 

<210>  154
<211>  821
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-70

<400>  154

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 

Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
                165                 170                 175     

Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
            180                 185                 190         

Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
        195                 200                 205             

Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
    210                 215                 220                 

Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
225                 230                 235                 240 

Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
                245                 250                 255     

Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
            260                 265                 270         

Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
        275                 280                 285             

Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
    290                 295                 300                 

Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
305                 310                 315                 320 

Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
                325                 330                 335     

Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
            340                 345                 350         

Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
        355                 360                 365             

Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
    370                 375                 380                 

Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
385                 390                 395                 400 

Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
                405                 410                 415     

Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
            420                 425                 430         

Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
        435                 440                 445             

Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
    450                 455                 460                 

Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
465                 470                 475                 480 

Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
                485                 490                 495     

Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
            500                 505                 510         

Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
        515                 520                 525             

Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
    530                 535                 540                 

Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
545                 550                 555                 560 

Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
                565                 570                 575     

Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
            580                 585                 590         

Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
        595                 600                 605             

Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
    610                 615                 620                 

Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
625                 630                 635                 640 

Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
                645                 650                 655     

Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
            660                 665                 670         

His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
        675                 680                 685             

Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
    690                 695                 700                 

Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
705                 710                 715                 720 

Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
                725                 730                 735     

Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly 
            740                 745                 750         

Ser Gly Gly Gly Gly Ser Phe Val Asn Gln His Leu Cys Gly Ser His 
        755                 760                 765             

Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr 
    770                 775                 780                 

Thr Pro Lys Thr Gly Ala Gly Ser Ser Ser Ala Ala Ala Pro Gln Thr 
785                 790                 795                 800 

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
                805                 810                 815     

Glu Asn Tyr Cys Asn 
            820     

<210>  155
<211>  199
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-1

<400>  155

Tyr Ser Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Arg 
        35                  40                  45              

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
    50                  55                  60                  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
65                  70                  75                  80  

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
                85                  90                  95      

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
            100                 105                 110         

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
        115                 120                 125             

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
    130                 135                 140                 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
145                 150                 155                 160 

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
                165                 170                 175     

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
            180                 185                 190         

Phe Tyr Phe Gln Glu Asp Glu 
        195                 

<210>  156
<211>  194
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-2

<400>  156

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Arg Pro Ser Gly Arg Lys 
        35                  40                  45              

Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr 
    50                  55                  60                  

Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro 
65                  70                  75                  80  

Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His 
                85                  90                  95      

Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val 
            100                 105                 110         

Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr 
        115                 120                 125             

Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg 
    130                 135                 140                 

Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly 
145                 150                 155                 160 

Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr 
                165                 170                 175     

Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu 
            180                 185                 190         

Asp Glu     

<210>  157
<211>  199
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-3

<400>  157

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Arg 
        35                  40                  45              

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
    50                  55                  60                  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
65                  70                  75                  80  

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
                85                  90                  95      

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
            100                 105                 110         

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
        115                 120                 125             

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
    130                 135                 140                 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
145                 150                 155                 160 

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
                165                 170                 175     

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
            180                 185                 190         

Phe Tyr Phe Gln Glu Asp Glu 
        195                 

<210>  158
<211>  204
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-4

<400>  158

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Gly 
        35                  40                  45              

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
    50                  55                  60                  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
65                  70                  75                  80  

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
                85                  90                  95      

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
            100                 105                 110         

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
        115                 120                 125             

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
    130                 135                 140                 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
145                 150                 155                 160 

Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
                165                 170                 175     

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
            180                 185                 190         

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200                 

<210>  159
<211>  209
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-5

<400>  159

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Gly 
        35                  40                  45              

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
    50                  55                  60                  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
65                  70                  75                  80  

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
                85                  90                  95      

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
            100                 105                 110         

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
        115                 120                 125             

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
    130                 135                 140                 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
145                 150                 155                 160 

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
                165                 170                 175     

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
            180                 185                 190         

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
        195                 200                 205             

Glu 
    
<210>  160
<211>  194
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-6

<400>  160

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Arg Pro Ser Gly Arg Lys 
        35                  40                  45              

Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr 
    50                  55                  60                  

Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro 
65                  70                  75                  80  

Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His 
                85                  90                  95      

Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val 
            100                 105                 110         

Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr 
        115                 120                 125             

Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg 
    130                 135                 140                 

Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly 
145                 150                 155                 160 

Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr 
                165                 170                 175     

Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu 
            180                 185                 190         

Asp Glu 
     
<210>  161
<211>  199
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-7

<400>  161

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Arg 
        35                  40                  45              

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
    50                  55                  60                  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
65                  70                  75                  80  

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
                85                  90                  95      

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
            100                 105                 110         

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
        115                 120                 125             

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
    130                 135                 140                 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
145                 150                 155                 160 

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
                165                 170                 175     

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
            180                 185                 190         

Phe Tyr Phe Gln Glu Asp Glu 
        195                 

<210>  162
<211>  204
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-8

<400>  162

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Gly 
        35                  40                  45              

Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
    50                  55                  60                  

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
65                  70                  75                  80  

Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
                85                  90                  95      

Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
            100                 105                 110         

His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
        115                 120                 125             

Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
    130                 135                 140                 

Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
145                 150                 155                 160 

Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
                165                 170                 175     

Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
            180                 185                 190         

Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200                 

<210>  163
<211>  209
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-9

<400>  163

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Gly 
        35                  40                  45              

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser 
    50                  55                  60                  

Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
65                  70                  75                  80  

Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
                85                  90                  95      

Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
            100                 105                 110         

Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
        115                 120                 125             

Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
    130                 135                 140                 

Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
145                 150                 155                 160 

Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
                165                 170                 175     

Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
            180                 185                 190         

Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
        195                 200                 205             

Glu 
   
<210>  164
<211>  195
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ IN-10

<400>  164

Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      

Val Asn Trp Leu Leu Ala Gln Lys Pro Ser Ser Gly Ala Pro Pro Pro 
            20                  25                  30          

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg 
        35                  40                  45              

Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
    50                  55                  60                  

Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
65                  70                  75                  80  

Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro 
                85                  90                  95      

His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys 
            100                 105                 110         

Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile 
        115                 120                 125             

Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile 
    130                 135                 140                 

Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro 
145                 150                 155                 160 

Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu 
                165                 170                 175     

Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln 
            180                 185                 190         

Glu Asp Glu 
        195 

<210>  165
<211>  206
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-11

<400>  165

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met 
    50                  55                  60                  

Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg 
65                  70                  75                  80  

Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu 
                85                  90                  95      

Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu 
            100                 105                 110         

Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp 
        115                 120                 125             

Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu 
    130                 135                 140                 

Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly 
145                 150                 155                 160 

Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys 
                165                 170                 175     

Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp 
            180                 185                 190         

Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200                 205     

<210>  166
<211>  196
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-12

<400>  166

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly 
        35                  40                  45              

Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
    50                  55                  60                  

Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
65                  70                  75                  80  

Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
                85                  90                  95      

Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
            100                 105                 110         

Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
        115                 120                 125             

Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
    130                 135                 140                 

Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
145                 150                 155                 160 

Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
                165                 170                 175     

Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
            180                 185                 190         

Gln Glu Asp Glu 
        195     

<210>  167
<211>  206
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-13

<400>  167

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met 
    50                  55                  60                  

Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg 
65                  70                  75                  80  

Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu 
                85                  90                  95      

Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu 
            100                 105                 110         

Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp 
        115                 120                 125             

Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu 
    130                 135                 140                 

Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly 
145                 150                 155                 160 

Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys 
                165                 170                 175     

Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp 
            180                 185                 190         

Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200                 205     

<210>  168
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-14

<400>  168

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  169
<211>  196
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-15

<400>  169

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly 
        35                  40                  45              

Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
    50                  55                  60                  

Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
65                  70                  75                  80  

Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
                85                  90                  95      

Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
            100                 105                 110         

Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
        115                 120                 125             

Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
    130                 135                 140                 

Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
145                 150                 155                 160 

Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
                165                 170                 175     

Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
            180                 185                 190         

Gln Glu Asp Glu 
        195     

<210>  170
<211>  187
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-16

<400>  170

Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      

Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          

Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe 
        35                  40                  45              

Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln 
    50                  55                  60                  

Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys 
65                  70                  75                  80  

Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His 
                85                  90                  95      

Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg 
            100                 105                 110         

Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys 
        115                 120                 125             

Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr 
    130                 135                 140                 

Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met 
145                 150                 155                 160 

Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val 
                165                 170                 175     

Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            180                 185         

<210>  171
<211>  182
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-17

<400>  171

Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      

Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Gly Gly Gly Ser Arg Pro 
            20                  25                  30          

Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val 
        35                  40                  45              

Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr 
    50                  55                  60                  

Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro 
65                  70                  75                  80  

Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys 
                85                  90                  95      

Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala 
            100                 105                 110         

Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe 
        115                 120                 125             

Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala 
    130                 135                 140                 

Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro 
145                 150                 155                 160 

Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe 
                165                 170                 175     

Tyr Phe Gln Glu Asp Glu 
            180         

<210>  172
<211>  196
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-18

<400>  172

Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      

Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          

Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly 
        35                  40                  45              

Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
    50                  55                  60                  

Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
65                  70                  75                  80  

Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
                85                  90                  95      

Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
            100                 105                 110         

Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
        115                 120                 125             

Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
    130                 135                 140                 

Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
145                 150                 155                 160 

Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
                165                 170                 175     

Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
            180                 185                 190         

Gln Glu Asp Glu 
        195     

<210>  173
<211>  182
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-19

<400>  173

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Arg Pro 
            20                  25                  30          

Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val 
        35                  40                  45              

Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr 
    50                  55                  60                  

Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro 
65                  70                  75                  80  

Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys 
                85                  90                  95      

Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala 
            100                 105                 110         

Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe 
        115                 120                 125             

Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala 
    130                 135                 140                 

Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro 
145                 150                 155                 160 

Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe 
                165                 170                 175     

Tyr Phe Gln Glu Asp Glu 
            180         

<210>  174
<211>  196
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-20

<400>  174

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Arg Pro Ser Gly 
        35                  40                  45              

Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
    50                  55                  60                  

Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
65                  70                  75                  80  

Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
                85                  90                  95      

Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
            100                 105                 110         

Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
        115                 120                 125             

Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
    130                 135                 140                 

Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
145                 150                 155                 160 

Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
                165                 170                 175     

Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
            180                 185                 190         

Gln Glu Asp Glu 
        195     

<210>  175
<211>  201
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-21

<400>  175

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              

Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
    50                  55                  60                  

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
65                  70                  75                  80  

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
                85                  90                  95      

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
            100                 105                 110         

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
        115                 120                 125             

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
    130                 135                 140                 

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
145                 150                 155                 160 

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
                165                 170                 175     

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
            180                 185                 190         

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        195                 200     

<210>  176
<211>  789
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-22

<400>  176

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Arg 
        35                  40                  45              

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
    50                  55                  60                  


Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
65                  70                  75                  80  

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
                85                  90                  95      

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
            100                 105                 110         

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
        115                 120                 125             

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
    130                 135                 140                 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
145                 150                 155                 160 

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
                165                 170                 175     

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
            180                 185                 190         

Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Asp Ala His Lys 
        195                 200                 205             

Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
    210                 215                 220                 

Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
225                 230                 235                 240 

Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
                245                 250                 255     

Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
            260                 265                 270         

Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
        275                 280                 285             

Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
    290                 295                 300                 

Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
305                 310                 315                 320 

Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
                325                 330                 335     

Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
            340                 345                 350         

Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
        355                 360                 365             

Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
    370                 375                 380                 

Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
385                 390                 395                 400 

Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
                405                 410                 415     

Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
            420                 425                 430         

Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
        435                 440                 445             

Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
    450                 455                 460                 

Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
465                 470                 475                 480 

Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
                485                 490                 495     

Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
            500                 505                 510         

Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
        515                 520                 525             

Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
    530                 535                 540                 

Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
545                 550                 555                 560 

Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
                565                 570                 575     

Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
            580                 585                 590         

Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
        595                 600                 605             

Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
    610                 615                 620                 

Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
625                 630                 635                 640 

Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
                645                 650                 655     

Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
            660                 665                 670         

Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
        675                 680                 685             

Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
    690                 695                 700                 

Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
705                 710                 715                 720 

Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
                725                 730                 735     

Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
            740                 745                 750         

Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
        755                 760                 765             

Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
    770                 775                 780                 

Ala Ala Leu Gly Leu 
785                 

<210>  177
<211>  789
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-23

<400>  177

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gly Gly Gly Gly Ser Arg 
        35                  40                  45              

Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp 
    50                  55                  60                  

Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly 
65                  70                  75                  80  

Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val 
                85                  90                  95      

Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met 
            100                 105                 110         

Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu 
        115                 120                 125             

Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg 
    130                 135                 140                 

Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser 
145                 150                 155                 160 

Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln 
                165                 170                 175     

Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys 
            180                 185                 190         

Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Asp Ala His Lys 
        195                 200                 205             

Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
    210                 215                 220                 

Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
225                 230                 235                 240 

Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
                245                 250                 255     

Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
            260                 265                 270         

Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
        275                 280                 285             

Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
    290                 295                 300                 

Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
305                 310                 315                 320 

Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
                325                 330                 335     

Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
            340                 345                 350         

Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
        355                 360                 365             

Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
    370                 375                 380                 

Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
385                 390                 395                 400 

Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
                405                 410                 415     

Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
            420                 425                 430         

Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
        435                 440                 445             

Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
    450                 455                 460                 

Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
465                 470                 475                 480 

Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
                485                 490                 495     

Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
            500                 505                 510         

Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
        515                 520                 525             

Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
    530                 535                 540                 

Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
545                 550                 555                 560 

Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
                565                 570                 575     

Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
            580                 585                 590         

Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
        595                 600                 605             

Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
    610                 615                 620                 

Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
625                 630                 635                 640 

Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
                645                 650                 655     

Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
            660                 665                 670         

Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
        675                 680                 685             

Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
    690                 695                 700                 

Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
705                 710                 715                 720 

Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
                725                 730                 735     

Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
            740                 745                 750         

Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
        755                 760                 765             

Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
    770                 775                 780                 

Ala Ala Leu Gly Leu 
785                 

<210>  178
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-24

<220>
<221>  MOD_RES
<222>  (85)..(85)
<223>  S-ǰ-PEG11-ǰ-S-GIP϶ģSǰװ
       ԭӣGIP϶ĵSEQ ID NO:197

<400>  178

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             

<210>  179
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-25

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S -ǰ-PEG40K 
       -ǰ-S-GIP϶ģSǰװԭӣGIP
       ϶ĵSEQ ID NO:198

<400>  179

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  180
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-26

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S -ǰ-PEG40K 
       -ǰ-S-GIP϶ģSǰװԭӣGIP
       ϶ĵSEQ ID NO:199

<400>  180

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  181
<211>  154
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-27

<220>
<221>  MOD_RES
<222>  (154)..(154)
<223>  S-ǰ-PEG11-ǰ-S-GIP϶ģSǰװ
       ԭӣGIP϶ĵSEQ ID NO:200

<400>  181

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu Cys 
145                 150                 

<210>  182
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-28

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  S-ǰ-PEG11-ǰ-S-GIP϶ģSǰװ
       ԭӣGIP϶ĵSEQ ID NO:201

<220>
<221>  MOD_RES
<222>  (117)..(117)
<223>  S-CH2-CONH-(CH2CH2O)4-(CH2)2-NH-(N-(HOOC(CH2)16CO)--Glu)

<400>  182

Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             


<210>  183
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-29

<220>
<221>  MOD_RES
<222>  (85)..(85)
<223>  S-ǰ-PEG40K-ǰ-S-GIP϶ģSǰװ
       ԭӣGIP϶ĵSEQ ID NO:202

<400>  183

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             

<210>  184
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ںϵ GI-30

<220>
<221>  MOD_RES
<222>  (116)..(116)
<223>  S-ǰ-PEG11-ǰ-S-GIP϶ģSǰװ
       ԭӣGIP϶ĵSEQ ID NO:203

<400>  184

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         


<210>  185
<211>  39
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<400>  185

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Cys 
        35                  

<210>  186
<211>  31
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<400>  186

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Cys 
            20                  25                  30      

<210>  187
<211>  31
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<400>  187

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Arg Gly 
            20                  25                  30      

<210>  188
<211>  39
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<400>  188

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      

Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Cys Asn Gly Gly Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser 
        35                  

<210>  189
<211>  31
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2-׻

<400>  189

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Cys 
            20                  25                  30      

<210>  190
<211>  31
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2-׻

<400>  190

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Arg Gly 
            20                  25                  30      

<210>  191
<211>  31
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2-׻

<400>  191

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Cys 
            20                  25                  30      

<210>  192
<211>  31
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2-׻

<400>  192

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      

Gln Ala Ala Cys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      

<210>  193
<211>  31
<212>  PRT
<213>  ˹

<220>
<223>  GLP-1϶

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  N-(N-(HOOC(CH2)14CO)--L-Glu)

<400>  193

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      

Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Cys 
            20                  25                  30      

<210>  194
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  IL-1ra

<400>  194

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  195
<211>  152
<212>  PRT
<213>  ˹

<220>
<223>  ׽-1׿

<400>  195

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      

Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              

Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  

Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  

Glu Ala Val Cys Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      

Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         

Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             

Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 

Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         

<210>  196
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  IL-1ra

<400>  196

Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      

Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          

Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              

Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  

Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  

Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      

Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         

Glu Ser Ala Ala Ser Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             

Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 

Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             

<210>  197
<211>  42
<212>  PRT
<213>  ˹

<220>
<223>  GIP϶

<400>  197

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Cys His Asn Ile Thr Gln 
        35                  40          

<210>  198
<211>  43
<212>  PRT
<213>  ˹

<220>
<223>  GIP϶

<400>  198

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              

<210>  199
<211>  43
<212>  PRT
<213>  ˹

<220>
<223>  GIP϶

<400>  199

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          

Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              

<210>  200
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  GIP϶

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2-׻

<400>  200

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Cys 
            20                  25                  30  

<210>  201
<211>  40
<212>  PRT
<213>  ˹

<220>
<223>  GIP϶

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2-׻

<400>  201

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  

<210>  202
<211>  39
<212>  PRT
<213>  ˹

<220>
<223>  GIP϶

<400>  202

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      

Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Pro Ser 
            20                  25                  30          

Ser Gly Ala Pro Pro Pro Cys 
        35                  

<210>  203
<211>  26
<212>  PRT
<213>  ˹

<220>
<223>  GIP϶

<400>  203

Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      

Phe Val Asn Trp Leu Leu Ala Gln Lys Cys 
            20                  25      



