                         SEQUENCE LISTING

<110>  New York University
       Carroll, William L.
       Meyer, Julia A.
 
<120>  METHODS AND COMPOSITIONS FOR THE PROGNOSIS AND TREATMENT OF 
       RELAPSED LEUKEMIA

<130>  29527.1261 (CAR01-02PCT)

<150>  US 61/643,489
<151>  2012-05-07

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  1
atgtcaacct cctggagtga tcggttacag aatgcagcag atatgcctgc taacatggat       60

aagcatgccc tgaaaaagta tcgtcgagaa gcctatcatc gggtgtttgt gaaccgaagt      120

ttagcaatgg aaaagataaa gtgttttggt tttgatatgg attataccct tgctgtgtac      180

aagtccccag agtatgagtc ccttggtttt gagcttactg tggagagatt agtttctatt      240

ggctatcccc aggagttgct cagctttgct tatgattcta cattccctac caggggactt      300

gtctttgaca cactgtatgg aaatcttttg aaagtcgatg cctatggaaa cctcttggtc      360

tgtgcacatg gatttaactt tataagggga ccagaaacta gagaacagta tccaaataaa      420

tttatccagc gagatgatac tgaaagattt tacattctga acacactatt caacctacca      480

gagacctacc tgttggcctg cctagtagat ttttttacta attgtcccag atataccagt      540

tgtgaaacag gatttaaaga tggggacctc ttcatgtcct accggagtat gttccaggat      600

gtaagagatg ctgttgactg ggttcattac aagggctccc ttaaggaaaa gacagttgaa      660

aatcttgaga agtatgtagt caaagatgga aaactgcctt tgcttctgag ccggatgaag      720

gaagtaggga aagtatttct tgctaccaac agtgactata aatatacaga taaaattatg      780

acttacctgt ttgacttccc acatggcccc aagcctggga gctcccatcg accatggcag      840

tcctactttg acttgatctt ggtggatgca cggaaaccac tcttttttgg agaaggcaca      900

gtactgcgtc aggtggatac taaaactggc aagctgaaaa ttggtaccta cacagggccc      960

ctacagcatg gtatcgtcta ctcaggaggt tcttctgata cgatctgtga cctgttggga     1020

gccaagggaa aagacatttt gtatattgga gatcacattt ttggggacat tttaaaatca     1080

aagaaacggc aagggtggcg aacttttttg gtgattcctg aactcgcaca ggagctacat     1140

gtctggactg acaagagttc acttttcgaa gaacttcaga gcttggatat tttcttggct     1200

gaactctaca agcatcttga cagcagtagc aatgagcgtc cagacatcag ttccatccag     1260

agacgtatta agaaagtaac tcatgacatg gacatgtgct atgggatgat gggaagcctg     1320

tttcgcagtg gctcccggca gacccttttt gccagtcaag tgatgcgtta tgctgacctc     1380

tatgcagcat ctttcatcaa cctgctgtat taccctttca gctacctctt cagggctgcc     1440

catgtcttga tgcctcatga atcaacggtg gagcacacac acgtagatat caatgagatg     1500

gagtctcctc ttgccacccg gaaccgcaca tcagtggatt tcaaagacac tgactacaag     1560

cggcaccagc tgacacggtc aattagtgag attaaacctc ccaacctctt cccactggcc     1620

ccccaggaaa ttacacactg ccatgacgaa gatgatgatg aagaggagga ggaggaggaa     1680

gaataa                                                                1686


<210>  2
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Ser Trp Ser Asp Arg Leu Gln Asn Ala Ala Asp Met Pro 
1               5                   10                  15      


Ala Asn Met Asp Lys His Ala Leu Lys Lys Tyr Arg Arg Glu Ala Tyr 
            20                  25                  30          


His Arg Val Phe Val Asn Arg Ser Leu Ala Met Glu Lys Ile Lys Cys 
        35                  40                  45              


Phe Gly Phe Asp Met Asp Tyr Thr Leu Ala Val Tyr Lys Ser Pro Glu 
    50                  55                  60                  


Tyr Glu Ser Leu Gly Phe Glu Leu Thr Val Glu Arg Leu Val Ser Ile 
65                  70                  75                  80  


Gly Tyr Pro Gln Glu Leu Leu Ser Phe Ala Tyr Asp Ser Thr Phe Pro 
                85                  90                  95      


Thr Arg Gly Leu Val Phe Asp Thr Leu Tyr Gly Asn Leu Leu Lys Val 
            100                 105                 110         


Asp Ala Tyr Gly Asn Leu Leu Val Cys Ala His Gly Phe Asn Phe Ile 
        115                 120                 125             


Arg Gly Pro Glu Thr Arg Glu Gln Tyr Pro Asn Lys Phe Ile Gln Arg 
    130                 135                 140                 


Asp Asp Thr Glu Arg Phe Tyr Ile Leu Asn Thr Leu Phe Asn Leu Pro 
145                 150                 155                 160 


Glu Thr Tyr Leu Leu Ala Cys Leu Val Asp Phe Phe Thr Asn Cys Pro 
                165                 170                 175     


Arg Tyr Thr Ser Cys Glu Thr Gly Phe Lys Asp Gly Asp Leu Phe Met 
            180                 185                 190         


Ser Tyr Arg Ser Met Phe Gln Asp Val Arg Asp Ala Val Asp Trp Val 
        195                 200                 205             


His Tyr Lys Gly Ser Leu Lys Glu Lys Thr Val Glu Asn Leu Glu Lys 
    210                 215                 220                 


Tyr Val Val Lys Asp Gly Lys Leu Pro Leu Leu Leu Ser Arg Met Lys 
225                 230                 235                 240 


Glu Val Gly Lys Val Phe Leu Ala Thr Asn Ser Asp Tyr Lys Tyr Thr 
                245                 250                 255     


Asp Lys Ile Met Thr Tyr Leu Phe Asp Phe Pro His Gly Pro Lys Pro 
            260                 265                 270         


Gly Ser Ser His Arg Pro Trp Gln Ser Tyr Phe Asp Leu Ile Leu Val 
        275                 280                 285             


Asp Ala Arg Lys Pro Leu Phe Phe Gly Glu Gly Thr Val Leu Arg Gln 
    290                 295                 300                 


Val Asp Thr Lys Thr Gly Lys Leu Lys Ile Gly Thr Tyr Thr Gly Pro 
305                 310                 315                 320 


Leu Gln His Gly Ile Val Tyr Ser Gly Gly Ser Ser Asp Thr Ile Cys 
                325                 330                 335     


Asp Leu Leu Gly Ala Lys Gly Lys Asp Ile Leu Tyr Ile Gly Asp His 
            340                 345                 350         


Ile Phe Gly Asp Ile Leu Lys Ser Lys Lys Arg Gln Gly Trp Arg Thr 
        355                 360                 365             


Phe Leu Val Ile Pro Glu Leu Ala Gln Glu Leu His Val Trp Thr Asp 
    370                 375                 380                 


Lys Ser Ser Leu Phe Glu Glu Leu Gln Ser Leu Asp Ile Phe Leu Ala 
385                 390                 395                 400 


Glu Leu Tyr Lys His Leu Asp Ser Ser Ser Asn Glu Arg Pro Asp Ile 
                405                 410                 415     


Ser Ser Ile Gln Arg Arg Ile Lys Lys Val Thr His Asp Met Asp Met 
            420                 425                 430         


Cys Tyr Gly Met Met Gly Ser Leu Phe Arg Ser Gly Ser Arg Gln Thr 
        435                 440                 445             


Leu Phe Ala Ser Gln Val Met Arg Tyr Ala Asp Leu Tyr Ala Ala Ser 
    450                 455                 460                 


Phe Ile Asn Leu Leu Tyr Tyr Pro Phe Ser Tyr Leu Phe Arg Ala Ala 
465                 470                 475                 480 


His Val Leu Met Pro His Glu Ser Thr Val Glu His Thr His Val Asp 
                485                 490                 495     


Ile Asn Glu Met Glu Ser Pro Leu Ala Thr Arg Asn Arg Thr Ser Val 
            500                 505                 510         


Asp Phe Lys Asp Thr Asp Tyr Lys Arg His Gln Leu Thr Arg Ser Ile 
        515                 520                 525             


Ser Glu Ile Lys Pro Pro Asn Leu Phe Pro Leu Ala Pro Gln Glu Ile 
    530                 535                 540                 


Thr His Cys His Asp Glu Asp Asp Asp Glu Glu Glu Glu Glu Glu Glu 
545                 550                 555                 560 


Glu 
    


<210>  3
<211>  4131
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtttagag ctggggaggc ctccaaacgc ccattgcctg ggccgtcgcc cccaagggtg       60

cggagtgtgg aggttgcccg ggggagggcc ggctacggat tcacgctttc gggacaggca      120

ccctgtgtgc tcagctgcgt catgagaggg agccctgcgg atttcgtggg cctccgagct      180

ggagaccaga tacttgctgt caatgaaatc aacgtgaaaa aagcatctca tgaagatgta      240

gtgaaattaa ttgggaagtg ctctggtgtc cttcacatgg tgattgctga aggcgtcggc      300

cgcttcgaat cctgttccag tgatgaagaa gggggactct atgaaggaaa aggctggctg      360

aagcccaagc tggattctaa agcactaggt ataaacagag cagagcgagt cgtggaggaa      420

atgcagtctg gtggaatttt caatatgatt tttgaaaacc cgagcctttg tgcgagcaat      480

tcagagccct tgaaattgaa acaaagatcc ctttcagagt cggccgcaac tcgatttgat      540

gttggacatg aaagtataaa taatccaaat cccaacatgc tttctaagga ggaaatatca      600

aaagttattc atgatgattc ggttttcagc attggactag aaagtcatga cgattttgca      660

ttggatgcaa gtattttaaa cgtggcgatg atcgtgggct acttaggctc cattgagctt      720

ccttccacga gctccaacct ggagtccgac agcttgcaag ccatccgcgg ctgcatgcgg      780

cgcctgcggg cagagcagaa aatccactcg ctggtgacca tgaagatcat gcacgactgt      840

gtgcagctga gcactgacaa ggctggagtc gtggccgagt acccggccga gaagctggcc      900

ttcagcgccg tgtgcccgga cgaccggcga tttttcgggt tggttaccat gcagacgaat      960

gacgacggga gcctggccca ggaggaggag ggcgccctgc ggacttcctg ccacgtgttc     1020

atggtggacc cagacttgtt taatcacaag atccaccaag gcattgctcg gcggtttggg     1080

tttgagtgca cggccgaccc agacaccaat ggctgtctgg aattcccggc gtcctccctc     1140

cccgtcctgc agttcatctc tgtcctgtac cgagacatgg gtgagctgat tgagggcatg     1200

cgggcccgcg cctttctgga cggggacgcc gatgcccacc agaacaacag caccagcagc     1260

aacagtgaca gcggcattgg gaacttccac caggaggaga agagcaaccg ggtccttgtg     1320

gtggacctgg gtgggagctc gagcagacac ggccccggag gcagcgcgtg ggacggtgtg     1380

ggtgggaggg gtgcccagcc ctggggtgct ccctggactg ggcccttctg tccggacccc     1440

gaagggagcc ccccatttga ggccgctcat cagactgaca ggttctggga cctaaacaag     1500

cacctagggc cagcctctcc tgtggaggtg cccccagctt ccttgaggag ctcagtcccc     1560

ccttccaaga ggggcaccgt gggtgctggc tgtggtttca accagcgctg gctcccggtc     1620

cacgtgctcc gggagtggca gtgcggacac accagcgacc aggactctta cacagattcc     1680

accgatggct ggtccagcat caactgcggc acactgcccc ctcctatgag caagatcccc     1740

gcagaccgct acagggtgga gggcagcttc gcgcagcccc cgctgaatgc cccgaagagg     1800

gagtggtcca ggaaggcctt tggaatgcaa agcatttttg gtccccatcg aaatgttcga     1860

aagactaagg aagataaaaa gggctcaaaa tttgggcggg gaactggact cactcagcct     1920

tctcaacgca cgtctgctcg gagatcattt gggagatcca agagattcag tatcactcgc     1980

tcccttgatg atcttgagtc tgcaactgtg tctgatggcg agttgacggg cgccgacctg     2040

aaggactgcg tcagcaacaa cagcctgagc agcaatgcca gcctccccag cgtgcagagc     2100

tgccggcgcc tgcgtgagag gagggtcgcc agctgggccg tgtcctttga gcgcctgctg     2160

caggaccccg tcggtgtccg ctacttctct gattttctaa ggaaagaatt cagtgaagaa     2220

aacattttat tctggcaggc ctgtgaatat tttaatcatg ttcctgcaca tgacaaaaag     2280

gagctttcct acagggcccg ggagattttc agtaagtttc tctgcagcaa agccaccacc     2340

ccggtcaaca tcgacagcca ggcccagcta gcagacgacg tcctccgcgc acctcaccca     2400

gacatgttca aggagcagca gctgcagatc ttcaatctca tgaagtttga tagctacact     2460

cgctttctga agtccccgct gtaccaggaa tgcatcctgg cggaagtgga gggccgtgca     2520

ctcccggact cgcagcaggt ccccagcagc ccggcttcca agcacagcct cggttcagac     2580

cactccagtg tgtccacgcc aaaaaagtta agtggaaaat caaaatccgg ccgatccctg     2640

aatgaagagc tgggggatga ggacagcgag aagaagcgga aaggcgcgtt tttctcgtgg     2700

tcgcggacca ggagcaccgg gaggtcccag aaaaagaggg agcacgggga ccacgcagac     2760

gacgccctgc atgccaatgg aggcctgtgt cgccgagagt cgcagggctc tgtgtcctct     2820

gcggggagcc tggacctgtc ggaggcctgc aggactttgg cacccgagaa ggacaaggcc     2880

accaagcact gctgcattca tctcccggat gggacatcct gcgtggtggc tgtcaaggcg     2940

ggcttctcca tcaaagacat cctgtccgga ctctgtgagc ggcatggcat caacggggcg     3000

gccgcggacc tcttcctggt gggcggggac aagcctctgg tgctgcacca agacagtagc     3060

atcttggagt caagggacct gcgcctagaa aagcgcacct tgtttcggct ggatcttgtt     3120

ccgattaacc ggtcagtggg actcaaggcc aagcccacca agcccgtcac ggaggtgctg     3180

cggcccgtgg tggccagata cggcctggac ctcagtggcc tgctggtgag gctgagtgga     3240

gagaaggagc ccctggacct tggcgcccct atatcgagtc tggacggaca gcgggttgtc     3300

ttggaggaga aggatccttc cagaggaaag gcatccgcag ataaacagaa aggtgtgcca     3360

gtgaaacaga acacagctgt aaattccagc tccagaaacc actcggctac gggagaggaa     3420

agaacactag gcaagtctaa ttctattaaa ataaaaggag aaaatggaaa aaatgctagg     3480

gatccccggc tttcaaagag agaagaatct attgcaaaga ttgggaaaaa aaaatatcag     3540

aaaattaatt tggacgaagc agaggagttt tttgagctta tttccaaagc tcagagcaac     3600

agagcagatg accaacgtgg gctgctaagg aaggaagacc tggtgttgcc agagttcctc     3660

cgtttacctc ctggttccac agaactcacc ctccccactc cagctgctgt ggccaagggc     3720

tttagcaaga gaagcgccac aggcaacggc cgggagagcg cctcccagcc tggcgagcag     3780

tgggagccag tccaggagag cagcgacagc ccgtccacca gcccgggctc agcctccagc     3840

ccccctggac ctcctgggac gacccccccc gggcagaagt ctcccagcgg gcccttctgc     3900

actccccagt cccccgtctc cctcgcgcag gagggcaccg cccagatctg gaagaggcag     3960

tctcaggaag tggaggccgg gggcatccag acggtggagg atgagcacgt ggccgagctg     4020

accctgatgg gggaggggga catcagcagc cccaacagca ccttgctgcc gccgccctcc     4080

accccccagg aagtgccagg accttccaga ccaggtacct ccaggttctg a              4131


<210>  4
<211>  1447
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Phe Arg Ala Gly Glu Ala Ser Lys Arg Pro Leu Pro Gly Pro Ser 
1               5                   10                  15      


Pro Pro Arg Val Arg Ser Val Glu Val Ala Arg Gly Arg Ala Gly Tyr 
            20                  25                  30          


Gly Phe Thr Leu Ser Gly Gln Ala Pro Cys Val Leu Ser Cys Val Met 
        35                  40                  45              


Arg Gly Ser Pro Ala Asp Phe Val Gly Leu Arg Ala Gly Asp Gln Ile 
    50                  55                  60                  


Leu Ala Val Asn Glu Ile Asn Val Lys Lys Ala Ser His Glu Asp Val 
65                  70                  75                  80  


Val Lys Leu Ile Gly Lys Cys Ser Gly Val Leu His Met Val Ile Ala 
                85                  90                  95      


Glu Gly Val Gly Arg Phe Glu Ser Cys Ser Ser Asp Glu Glu Gly Gly 
            100                 105                 110         


Leu Tyr Glu Gly Lys Gly Trp Leu Lys Pro Lys Leu Asp Ser Lys Ala 
        115                 120                 125             


Leu Gly Ile Asn Arg Ala Glu Arg Val Val Glu Glu Met Gln Ser Gly 
    130                 135                 140                 


Gly Ile Phe Asn Met Ile Phe Glu Asn Pro Ser Leu Cys Ala Ser Asn 
145                 150                 155                 160 


Ser Glu Pro Leu Lys Leu Lys Gln Arg Ser Leu Ser Glu Ser Ala Ala 
                165                 170                 175     


Thr Arg Phe Asp Val Gly His Glu Ser Ile Asn Asn Pro Asn Pro Asn 
            180                 185                 190         


Met Leu Ser Lys Glu Glu Ile Ser Lys Val Ile His Asp Asp Ser Val 
        195                 200                 205             


Phe Ser Ile Gly Leu Glu Ser His Asp Asp Phe Ala Leu Asp Ala Ser 
    210                 215                 220                 


Ile Leu Asn Val Ala Met Ile Val Gly Tyr Leu Gly Ser Ile Glu Leu 
225                 230                 235                 240 


Pro Ser Thr Ser Ser Asn Leu Glu Ser Asp Ser Leu Gln Ala Ile Arg 
                245                 250                 255     


Gly Cys Met Arg Arg Leu Arg Ala Glu Gln Lys Ile His Ser Leu Val 
            260                 265                 270         


Thr Met Lys Ile Met His Asp Cys Val Gln Leu Ser Thr Asp Lys Ala 
        275                 280                 285             


Gly Val Val Ala Glu Tyr Pro Ala Glu Lys Leu Ala Phe Ser Ala Val 
    290                 295                 300                 


Cys Pro Asp Asp Arg Arg Phe Phe Gly Leu Val Thr Met Gln Thr Asn 
305                 310                 315                 320 


Asp Asp Gly Ser Leu Ala Gln Glu Glu Glu Gly Ala Leu Arg Thr Ser 
                325                 330                 335     


Cys His Val Phe Met Val Asp Pro Asp Leu Phe Asn His Lys Ile His 
            340                 345                 350         


Gln Gly Ile Ala Arg Arg Phe Gly Phe Glu Cys Thr Ala Asp Pro Asp 
        355                 360                 365             


Thr Asn Gly Cys Leu Glu Phe Pro Ala Ser Ser Leu Pro Val Leu Gln 
    370                 375                 380                 


Phe Ile Ser Val Leu Tyr Arg Asp Met Gly Glu Leu Ile Glu Gly Met 
385                 390                 395                 400 


Arg Ala Arg Ala Phe Leu Asp Gly Asp Ala Asp Ala His Gln Asn Asn 
                405                 410                 415     


Ser Thr Ser Ser Asn Ser Asp Ser Gly Ile Gly Asn Phe His Gln Glu 
            420                 425                 430         


Glu Lys Ser Asn Arg Val Leu Val Val Asp Leu Gly Gly Ser Ser Ser 
        435                 440                 445             


Arg His Gly Pro Gly Gly Ser Ala Trp Asp Gly Val Gly Gly Arg Gly 
    450                 455                 460                 


Ala Gln Pro Trp Gly Ala Pro Trp Thr Gly Pro Phe Cys Pro Asp Pro 
465                 470                 475                 480 


Glu Gly Ser Pro Pro Phe Glu Ala Ala His Gln Thr Asp Arg Phe Trp 
                485                 490                 495     


Asp Leu Asn Lys His Leu Gly Pro Ala Ser Pro Val Glu Val Pro Pro 
            500                 505                 510         


Ala Ser Leu Arg Ser Ser Val Pro Pro Ser Lys Arg Gly Thr Val Gly 
        515                 520                 525             


Ala Gly Cys Gly Phe Asn Gln Arg Trp Leu Pro Val His Val Leu Arg 
    530                 535                 540                 


Glu Trp Gln Cys Gly His Thr Ser Asp Gln Asp Ser Tyr Thr Asp Ser 
545                 550                 555                 560 


Thr Asp Gly Trp Ser Ser Ile Asn Cys Gly Thr Leu Pro Pro Pro Met 
                565                 570                 575     


Ser Lys Ile Pro Ala Asp Arg Tyr Arg Val Glu Gly Ser Phe Ala Gln 
            580                 585                 590         


Pro Pro Leu Asn Ala Pro Lys Arg Glu Trp Ser Arg Lys Ala Phe Gly 
        595                 600                 605             


Met Gln Ser Ile Phe Gly Pro His Arg Asn Val Arg Lys Thr Lys Glu 
    610                 615                 620                 


Asp Lys Lys Gly Ser Lys Phe Gly Arg Gly Thr Gly Leu Thr Gln Pro 
625                 630                 635                 640 


Ser Gln Arg Thr Ser Ala Arg Arg Ser Phe Gly Arg Ser Lys Arg Phe 
                645                 650                 655     


Ser Ile Thr Arg Ser Leu Asp Asp Leu Glu Ser Ala Thr Val Ser Asp 
            660                 665                 670         


Gly Glu Leu Thr Gly Ala Asp Leu Lys Asp Cys Val Ser Asn Asn Ser 
        675                 680                 685             


Leu Ser Ser Asn Ala Ser Leu Pro Ser Val Gln Ser Cys Arg Arg Leu 
    690                 695                 700                 


Arg Glu Arg Arg Val Ala Ser Trp Ala Val Ser Phe Glu Arg Leu Leu 
705                 710                 715                 720 


Gln Asp Pro Val Gly Val Arg Tyr Phe Ser Asp Phe Leu Arg Lys Glu 
                725                 730                 735     


Phe Ser Glu Glu Asn Ile Leu Phe Trp Gln Ala Cys Glu Tyr Phe Asn 
            740                 745                 750         


His Val Pro Ala His Asp Lys Lys Glu Leu Ser Tyr Arg Ala Arg Glu 
        755                 760                 765             


Ile Phe Ser Lys Phe Leu Cys Ser Lys Ala Thr Thr Pro Val Asn Ile 
    770                 775                 780                 


Asp Ser Gln Ala Gln Leu Ala Asp Asp Val Leu Arg Ala Pro His Pro 
785                 790                 795                 800 


Asp Met Phe Lys Glu Gln Gln Leu Gln Ile Phe Asn Leu Met Lys Phe 
                805                 810                 815     


Asp Ser Tyr Thr Arg Phe Leu Lys Ser Pro Leu Tyr Gln Glu Cys Ile 
            820                 825                 830         


Leu Ala Glu Val Glu Gly Arg Ala Leu Pro Asp Ser Gln Gln Val Pro 
        835                 840                 845             


Ser Ser Pro Ala Ser Lys His Ser Leu Gly Ser Asp His Ser Ser Val 
    850                 855                 860                 


Ser Thr Pro Lys Lys Leu Ser Gly Lys Ser Lys Ser Gly Arg Ser Leu 
865                 870                 875                 880 


Asn Glu Glu Leu Gly Asp Glu Asp Ser Glu Lys Lys Arg Lys Gly Ala 
                885                 890                 895     


Phe Phe Ser Trp Ser Arg Thr Arg Ser Thr Gly Arg Ser Gln Lys Lys 
            900                 905                 910         


Arg Glu His Gly Asp His Ala Asp Asp Ala Leu His Ala Asn Gly Gly 
        915                 920                 925             


Leu Cys Arg Arg Glu Ser Gln Gly Ser Val Ser Ser Ala Gly Ser Leu 
    930                 935                 940                 


Asp Leu Ser Glu Ala Cys Arg Thr Leu Ala Pro Glu Lys Asp Lys Ala 
945                 950                 955                 960 


Thr Lys His Cys Cys Ile His Leu Pro Asp Gly Thr Ser Cys Val Val 
                965                 970                 975     


Ala Val Lys Ala Gly Phe Ser Ile Lys Asp Ile Leu Ser Gly Leu Cys 
            980                 985                 990         


Glu Arg His Gly Ile Asn Gly Ala  Ala Ala Asp Leu Phe  Leu Val Gly 
        995                 1000                 1005             


Gly Asp  Lys Pro Leu Val Leu  His Gln Asp Ser Ser  Ile Leu Glu 
    1010                 1015                 1020             


Ser Arg  Asp Leu Arg Leu Glu  Lys Arg Thr Leu Phe  Arg Leu Asp 
    1025                 1030                 1035             


Leu Val  Pro Ile Asn Arg Ser  Val Gly Leu Lys Ala  Lys Pro Thr 
    1040                 1045                 1050             


Lys Pro  Val Thr Glu Val Leu  Arg Pro Val Val Ala  Arg Tyr Gly 
    1055                 1060                 1065             


Leu Asp  Leu Ser Gly Leu Leu  Val Arg Leu Ser Gly  Glu Lys Glu 
    1070                 1075                 1080             


Pro Leu  Asp Leu Gly Ala Pro  Ile Ser Ser Leu Asp  Gly Gln Arg 
    1085                 1090                 1095             


Val Val  Leu Glu Glu Lys Asp  Pro Ser Arg Gly Lys  Ala Ser Ala 
    1100                 1105                 1110             


Asp Lys  Gln Lys Gly Val Pro  Val Lys Gln Asn Thr  Ala Val Asn 
    1115                 1120                 1125             


Ser Ser  Ser Arg Asn His Ser  Ala Thr Gly Glu Glu  Arg Thr Leu 
    1130                 1135                 1140             


Gly Lys  Ser Asn Ser Ile Lys  Ile Lys Gly Glu Asn  Gly Lys Asn 
    1145                 1150                 1155             


Ala Arg  Asp Pro Arg Leu Ser  Lys Arg Glu Glu Ser  Ile Ala Lys 
    1160                 1165                 1170             


Ile Gly  Lys Lys Lys Tyr Gln  Lys Ile Asn Leu Asp  Glu Ala Glu 
    1175                 1180                 1185             


Glu Phe  Phe Glu Leu Ile Ser  Lys Ala Gln Ser Asn  Arg Ala Asp 
    1190                 1195                 1200             


Asp Gln  Arg Gly Leu Leu Arg  Lys Glu Asp Leu Val  Leu Pro Glu 
    1205                 1210                 1215             


Phe Leu  Arg Leu Pro Pro Gly  Ser Thr Glu Leu Thr  Leu Pro Thr 
    1220                 1225                 1230             


Pro Ala  Ala Val Ala Lys Gly  Phe Ser Lys Arg Ser  Ala Thr Gly 
    1235                 1240                 1245             


Asn Gly  Arg Glu Ser Ala Ser  Gln Pro Gly Glu Gln  Trp Glu Pro 
    1250                 1255                 1260             


Val Gln  Glu Ser Ser Asp Ser  Pro Ser Thr Ser Pro  Gly Ser Ala 
    1265                 1270                 1275             


Ser Ser  Pro Pro Gly Pro Pro  Gly Thr Thr Pro Pro  Gly Gln Lys 
    1280                 1285                 1290             


Ser Pro  Ser Gly Pro Phe Cys  Thr Pro Gln Ser Pro  Val Ser Leu 
    1295                 1300                 1305             


Ala Gln  Glu Gly Thr Ala Gln  Ile Trp Lys Arg Gln  Ser Gln Glu 
    1310                 1315                 1320             


Val Glu  Ala Gly Gly Ile Gln  Thr Val Glu Asp Glu  His Val Ala 
    1325                 1330                 1335             


Glu Leu  Thr Leu Met Gly Glu  Gly Asp Ile Ser Ser  Pro Asn Ser 
    1340                 1345                 1350             


Thr Leu  Leu Pro Pro Pro Ser  Thr Pro Gln Glu Val  Pro Gly Pro 
    1355                 1360                 1365             


Ser Arg  Pro Gly Ser Gly Thr  His Gly Ser Arg Asp  Leu Pro Val 
    1370                 1375                 1380             


Asn Arg  Ile Ile Asp Val Asp  Leu Val Thr Gly Ser  Ala Pro Gly 
    1385                 1390                 1395             


Arg Asp  Gly Gly Ile Ala Gly  Ala Gln Ala Gly Pro  Gly Arg Ser 
    1400                 1405                 1410             


Gln Ala  Ser Gly Gly Pro Pro  Thr Ser Asp Leu Pro  Gly Leu Gly 
    1415                 1420                 1425             


Pro Val  Pro Gly Glu Pro Ala  Lys Pro Lys Thr Ser  Ala His His 
    1430                 1435                 1440             


Ala Thr  Phe Val 
    1445         


<210>  5
<211>  4425
<212>  DNA
<213>  Home sapiens

<400>  5
atggcccgcc tagccgcagt gctctggaat ctgtgtgtca ccgccgtcct ggtcacctcg       60

gccacccaag gcctgagccg ggccgggctc ccgttcgggc tgatgcgccg ggagctggcg      120

tgtgaaggct accccatcga gctgcggtgc cccggcagcg acgtcatcat ggtggagaat      180

gccaactacg ggcgcacgga cgacaagatt tgcgatgctg accctttcca gatggagaat      240

gtgcagtgct acctgccgga cgccttcaag atcatgtcac agaggtgtaa caaccgcacc      300

cagtgcgtgg tggtcgccgg ctcggatgcc tttcctgacc cctgtcctgg gacctacaag      360

tacctggagg tgcagtacga ctgtgtcccc tacaaagtgg agcagaaagt cttcgtgtgc      420

ccagggaccc tgcagaaggt gctggagccc acctcgacac acgagtcaga gcaccagtct      480

ggcgcatggt gcaaggaccc gctgcaggcg ggtgaccgca tctacgtgat gccctggatc      540

ccctaccgca cggacacact gactgagtat gcctcgtggg aggactacgt ggccgcccgc      600

cacaccacca cctaccgcct gcccaaccgc gtggatggca caggctttgt ggtctacgat      660

ggtgccgtct tctacaacaa ggagcgcacg cgcaacatcg tcaagtatga cctacggacg      720

cgcatcaaga gcggggagac ggtcatcaat accgccaact accatgacac ctcgccctac      780

cgctggggcg gaaagaccga cattgacctg gcggtggacg agaacgggct gtgggtcatc      840

tacgccactg agggcaacaa cgggcggctg gtggtgagcc agctgaaccc ctacacactg      900

cgctttgagg gcacgtggga gacgggttac gacaagcgct cggcatccaa cgccttcatg      960

gtgtgtgggg tcctgtacgt cctgcgttcc gtgtacgtgg atgatgacag cgaggcggct     1020

ggcaaccgcg tggactatgc cttcaacacc aatgccaacc gcgaggagcc tgtcagcctc     1080

accttcccca acccctacca gttcatctcc tccgttgact acaaccctcg cgacaaccag     1140

ctgtacgtct ggaacaacta tttcgtggtg cgctacagcc tggagttcgg gccgcccgac     1200

cccagtgctg gcccagccac ttccccaccc ctcagcacga ccaccacagc caggcccacg     1260

cccctcacca gcacagcctc gcccgcagcc accaccccgc tccgccgggc acccctcacc     1320

acgcacccag tgggtgccat caaccagctg ggacctgatc tgcctccagc cacagcccca     1380

gtccccagca cccggcggcc cccagccccg aatctacacg tgtcccctga gctcttctgc     1440

gagccccgag aggtacggcg ggtccagtgg ccggccaccc agcagggcat gctggtggag     1500

aggccctgcc ccaaggggac tcgaggaatt gcctccttcc agtgtctacc agccttgggg     1560

ctctggaacc cccggggccc tgacctcagc aactgcacct ccccctgggt caaccaggtg     1620

gcccagaaga tcaagagtgg ggagaacgcg gccaacatcg ccagcgagct ggcccgacac     1680

acccggggct ccatctacgc gggggacgtc tcctcctctg tgaagctgat ggagcagctg     1740

ctggacatcc tggatgccca gctgcaggcc ctgcggccca tcgagcgcga gtcagccggc     1800

aagaactaca acaagatgca caagcgagag agaacttgta aggattatat caaggccgtg     1860

gtggagacag tggacaatct gctccggcca gaagctctgg agtcctggaa ggacatgaat     1920

gccacggagc aggtgcacac ggccaccatg ctcctcgacg tcctggagga gggcgccttc     1980

ctgctggccg acaatgtcag ggagcctgcc cgcttcctgg ctgccaagga gaacgtggtc     2040

ctggaggtca cagtcctgaa cacagagggc caggtgcagg agctggtgtt cccccaggag     2100

gagtacccga gaaagaactc catccagctg tctgccaaaa ccatcaagca gaacagccgc     2160

aatggggtgg tcaaagttgt cttcatcctc tacaacaacc tgggcctctt cctgtccacg     2220

gagaatgcca cagtgaagct ggccggcgaa gcaggcccgg gtggccctgg gggcgcctct     2280

ctagtggtga actcacaggt catcgcagca tccatcaaca aggagtccag ccgcgtcttc     2340

ctcatggacc ctgtcatctt caccgtggcc cacctggagg acaagaacca cttcaatgct     2400

aactgctcct tctggaacta ctcggagcgt tccatgctgg gctactggtc gacccaaggc     2460

tgccgcctgg tggagtccaa caagacccat accacgtgtg cctgcagcca cctcaccaac     2520

ttcgctgtgc tcatggctca ccgtgagatc taccagggcc gcatcaacga gctgctgctg     2580

tcggtcatca cctgggtggg cattgtgatc tccctggtct gcttggccat ctgcatctcc     2640

accttctgct tcctgcgggg gctgcagacc gaccgcaaca ccatccacaa gaacctgtgc     2700

atcaacctct tcctggctga gctgctcttc ctggtcggga tcgacaagac tcagtatgag     2760

attgcctgcc ccatcttcgc cggcctgctg cactatttct tcctggctgc cttctcctgg     2820

ctgtgcctgg agggcgtgca cctctacctg ctactagtgg aggtgtttga gagcgagtat     2880

tcccgcacca agtactacta cctgggtggc tactgcttcc cggccctggt ggtgggcatc     2940

gcggctgcca ttgactaccg cagctacggc accgagaagg cctgctggct ccgagtggac     3000

aattacttca tctggagttt catcgggcca gtctccttcg ttatcgtggt caacctggtg     3060

ttcctcatgg tgaccctgca caagatgatc cgaagctcat ctgtgctcaa gcccgactcc     3120

agccgcctgg acaacattaa atcctgggcg ctgggggcca tcgcgctgct gttcctgctg     3180

ggcctcacct gggctttcgg cctcctcttc atcaacaagg agtcggtggt catggcctat     3240

ctcttcacca ccttcaacgc cttccagggg gtcttcatct tcgtctttca ctgcgcctta     3300

cagaagaagg tgcacaagga gtacagcaag tgcctgcgtc actcctactg ctgcatccgc     3360

tccccacccg ggggcactca cggatccctc aagacctcag ccatgcgaag caacacccgc     3420

tactacacag ggacccagag ccgaattcgg aggatgtgga atgacactgt gaggaaacag     3480

acggagtcct ccttcatggc gggtgacatc aacagcaccc ccaccctgaa ccgaggtacc     3540

atggggaacc acctgctgac caaccccgtg ctgcagcccc gtgggggcac cagtccctac     3600

aacaccctca tcgccgagtc agtgggcttc aatccctcct cgccccctgt cttcaactcc     3660

ccagggagct accgggaacc caagcacccc ttgggaggcc gggaagcctg tggcatggac     3720

accctgcccc tgaacggcaa cttcaataac agttactcct tgcgaagtgg ggatttccct     3780

cccggggatg ggggccctga gccgccccga ggccggaacc tagccgatgc ggcggccttt     3840

gagaagatga tcatctcaga gctggtgcac aacaacctgc gggggagcag cagcgcggcc     3900

aagggccctc caccgcctga gccccctgtg ccacctgtgc cagggggcgg gggcgaggaa     3960

gaggcgggcg ggcccggggg tgctgaccgg gccgagattg aacttctcta taaggccctg     4020

gaggagcctc tgctgctgcc ccgggcccag tcggtgctgt accagagcga tctggacgag     4080

tcggagagct gcacggccga ggacggcgcc accagccggc ccctctcctc ccctcctggc     4140

cgggactccc tctatgccag cggggccaac ctgcgggact caccctccta cccggacagc     4200

agccctgagg ggcccagtga ggccctgccc ccaccccctc ccgcaccccc cggccccccc     4260

gaaatctact acacctcgcg cccgccagcc ctggtggccc ggaatcccct gcagggctac     4320

taccaggtgc ggcgtcctag ccacgagggc tacctggcag ccccaggcct tgaggggcca     4380

gggcccgatg gggacgggca gatgcagctg gtcaccagtc tctga                     4425


<210>  6
<211>  1474
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Arg Leu Ala Ala Val Leu Trp Asn Leu Cys Val Thr Ala Val 
1               5                   10                  15      


Leu Val Thr Ser Ala Thr Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
            20                  25                  30          


Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
        35                  40                  45              


Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
    50                  55                  60                  


Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
65                  70                  75                  80  


Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                85                  90                  95      


Asn Asn Arg Thr Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
            100                 105                 110         


Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
        115                 120                 125             


Val Pro Tyr Lys Val Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
    130                 135                 140                 


Gln Lys Val Leu Glu Pro Thr Ser Thr His Glu Ser Glu His Gln Ser 
145                 150                 155                 160 


Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val 
                165                 170                 175     


Met Pro Trp Ile Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ala Ser 
            180                 185                 190         


Trp Glu Asp Tyr Val Ala Ala Arg His Thr Thr Thr Tyr Arg Leu Pro 
        195                 200                 205             


Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
    210                 215                 220                 


Tyr Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Tyr Asp Leu Arg Thr 
225                 230                 235                 240 


Arg Ile Lys Ser Gly Glu Thr Val Ile Asn Thr Ala Asn Tyr His Asp 
                245                 250                 255     


Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
            260                 265                 270         


Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gly Asn Asn Gly 
        275                 280                 285             


Arg Leu Val Val Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Gly 
    290                 295                 300                 


Thr Trp Glu Thr Gly Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met 
305                 310                 315                 320 


Val Cys Gly Val Leu Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp 
                325                 330                 335     


Ser Glu Ala Ala Gly Asn Arg Val Asp Tyr Ala Phe Asn Thr Asn Ala 
            340                 345                 350         


Asn Arg Glu Glu Pro Val Ser Leu Thr Phe Pro Asn Pro Tyr Gln Phe 
        355                 360                 365             


Ile Ser Ser Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
    370                 375                 380                 


Asn Asn Tyr Phe Val Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
385                 390                 395                 400 


Pro Ser Ala Gly Pro Ala Thr Ser Pro Pro Leu Ser Thr Thr Thr Thr 
                405                 410                 415     


Ala Arg Pro Thr Pro Leu Thr Ser Thr Ala Ser Pro Ala Ala Thr Thr 
            420                 425                 430         


Pro Leu Arg Arg Ala Pro Leu Thr Thr His Pro Val Gly Ala Ile Asn 
        435                 440                 445             


Gln Leu Gly Pro Asp Leu Pro Pro Ala Thr Ala Pro Val Pro Ser Thr 
    450                 455                 460                 


Arg Arg Pro Pro Ala Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys 
465                 470                 475                 480 


Glu Pro Arg Glu Val Arg Arg Val Gln Trp Pro Ala Thr Gln Gln Gly 
                485                 490                 495     


Met Leu Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Ile Ala Ser 
            500                 505                 510         


Phe Gln Cys Leu Pro Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp 
        515                 520                 525             


Leu Ser Asn Cys Thr Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile 
    530                 535                 540                 


Lys Ser Gly Glu Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His 
545                 550                 555                 560 


Thr Arg Gly Ser Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu 
                565                 570                 575     


Met Glu Gln Leu Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg 
            580                 585                 590         


Pro Ile Glu Arg Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys 
        595                 600                 605             


Arg Glu Arg Thr Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Thr Val 
    610                 615                 620                 


Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn 
625                 630                 635                 640 


Ala Thr Glu Gln Val His Thr Ala Thr Met Leu Leu Asp Val Leu Glu 
                645                 650                 655     


Glu Gly Ala Phe Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe 
            660                 665                 670         


Leu Ala Ala Lys Glu Asn Val Val Leu Glu Val Thr Val Leu Asn Thr 
        675                 680                 685             


Glu Gly Gln Val Gln Glu Leu Val Phe Pro Gln Glu Glu Tyr Pro Arg 
    690                 695                 700                 


Lys Asn Ser Ile Gln Leu Ser Ala Lys Thr Ile Lys Gln Asn Ser Arg 
705                 710                 715                 720 


Asn Gly Val Val Lys Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu 
                725                 730                 735     


Phe Leu Ser Thr Glu Asn Ala Thr Val Lys Leu Ala Gly Glu Ala Gly 
            740                 745                 750         


Pro Gly Gly Pro Gly Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile 
        755                 760                 765             


Ala Ala Ser Ile Asn Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro 
    770                 775                 780                 


Val Ile Phe Thr Val Ala His Leu Glu Asp Lys Asn His Phe Asn Ala 
785                 790                 795                 800 


Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp 
                805                 810                 815     


Ser Thr Gln Gly Cys Arg Leu Val Glu Ser Asn Lys Thr His Thr Thr 
            820                 825                 830         


Cys Ala Cys Ser His Leu Thr Asn Phe Ala Val Leu Met Ala His Arg 
        835                 840                 845             


Glu Ile Tyr Gln Gly Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Thr 
    850                 855                 860                 


Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser 
865                 870                 875                 880 


Thr Phe Cys Phe Leu Arg Gly Leu Gln Thr Asp Arg Asn Thr Ile His 
                885                 890                 895     


Lys Asn Leu Cys Ile Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val 
            900                 905                 910         


Gly Ile Asp Lys Thr Gln Tyr Glu Ile Ala Cys Pro Ile Phe Ala Gly 
        915                 920                 925             


Leu Leu His Tyr Phe Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu 
    930                 935                 940                 


Gly Val His Leu Tyr Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr 
945                 950                 955                 960 


Ser Arg Thr Lys Tyr Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu 
                965                 970                 975     


Val Val Gly Ile Ala Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Thr Glu 
            980                 985                 990         


Lys Ala Cys Trp Leu Arg Val Asp  Asn Tyr Phe Ile Trp  Ser Phe Ile 
        995                 1000                 1005             


Gly Pro  Val Ser Phe Val Ile  Val Val Asn Leu Val  Phe Leu Met 
    1010                 1015                 1020             


Val Thr  Leu His Lys Met Ile  Arg Ser Ser Ser Val  Leu Lys Pro 
    1025                 1030                 1035             


Asp Ser  Ser Arg Leu Asp Asn  Ile Lys Ser Trp Ala  Leu Gly Ala 
    1040                 1045                 1050             


Ile Ala  Leu Leu Phe Leu Leu  Gly Leu Thr Trp Ala  Phe Gly Leu 
    1055                 1060                 1065             


Leu Phe  Ile Asn Lys Glu Ser  Val Val Met Ala Tyr  Leu Phe Thr 
    1070                 1075                 1080             


Thr Phe  Asn Ala Phe Gln Gly  Val Phe Ile Phe Val  Phe His Cys 
    1085                 1090                 1095             


Ala Leu  Gln Lys Lys Val His  Lys Glu Tyr Ser Lys  Cys Leu Arg 
    1100                 1105                 1110             


His Ser  Tyr Cys Cys Ile Arg  Ser Pro Pro Gly Gly  Thr His Gly 
    1115                 1120                 1125             


Ser Leu  Lys Thr Ser Ala Met  Arg Ser Asn Thr Arg  Tyr Tyr Thr 
    1130                 1135                 1140             


Gly Thr  Gln Ser Arg Ile Arg  Arg Met Trp Asn Asp  Thr Val Arg 
    1145                 1150                 1155             


Lys Gln  Thr Glu Ser Ser Phe  Met Ala Gly Asp Ile  Asn Ser Thr 
    1160                 1165                 1170             


Pro Thr  Leu Asn Arg Gly Thr  Met Gly Asn His Leu  Leu Thr Asn 
    1175                 1180                 1185             


Pro Val  Leu Gln Pro Arg Gly  Gly Thr Ser Pro Tyr  Asn Thr Leu 
    1190                 1195                 1200             


Ile Ala  Glu Ser Val Gly Phe  Asn Pro Ser Ser Pro  Pro Val Phe 
    1205                 1210                 1215             


Asn Ser  Pro Gly Ser Tyr Arg  Glu Pro Lys His Pro  Leu Gly Gly 
    1220                 1225                 1230             


Arg Glu  Ala Cys Gly Met Asp  Thr Leu Pro Leu Asn  Gly Asn Phe 
    1235                 1240                 1245             


Asn Asn  Ser Tyr Ser Leu Arg  Ser Gly Asp Phe Pro  Pro Gly Asp 
    1250                 1255                 1260             


Gly Gly  Pro Glu Pro Pro Arg  Gly Arg Asn Leu Ala  Asp Ala Ala 
    1265                 1270                 1275             


Ala Phe  Glu Lys Met Ile Ile  Ser Glu Leu Val His  Asn Asn Leu 
    1280                 1285                 1290             


Arg Gly  Ser Ser Ser Ala Ala  Lys Gly Pro Pro Pro  Pro Glu Pro 
    1295                 1300                 1305             


Pro Val  Pro Pro Val Pro Gly  Gly Gly Gly Glu Glu  Glu Ala Gly 
    1310                 1315                 1320             


Gly Pro  Gly Gly Ala Asp Arg  Ala Glu Ile Glu Leu  Leu Tyr Lys 
    1325                 1330                 1335             


Ala Leu  Glu Glu Pro Leu Leu  Leu Pro Arg Ala Gln  Ser Val Leu 
    1340                 1345                 1350             


Tyr Gln  Ser Asp Leu Asp Glu  Ser Glu Ser Cys Thr  Ala Glu Asp 
    1355                 1360                 1365             


Gly Ala  Thr Ser Arg Pro Leu  Ser Ser Pro Pro Gly  Arg Asp Ser 
    1370                 1375                 1380             


Leu Tyr  Ala Ser Gly Ala Asn  Leu Arg Asp Ser Pro  Ser Tyr Pro 
    1385                 1390                 1395             


Asp Ser  Ser Pro Glu Gly Pro  Ser Glu Ala Leu Pro  Pro Pro Pro 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Pro Pro  Glu Ile Tyr Tyr Thr  Ser Arg Pro 
    1415                 1420                 1425             


Pro Ala  Leu Val Ala Arg Asn  Pro Leu Gln Gly Tyr  Tyr Gln Val 
    1430                 1435                 1440             


Arg Arg  Pro Ser His Glu Gly  Tyr Leu Ala Ala Pro  Gly Leu Glu 
    1445                 1450                 1455             


Gly Pro  Gly Pro Asp Gly Asp  Gly Gln Met Gln Leu  Val Thr Ser 
    1460                 1465                 1470             


Leu 
    


<210>  7
<211>  3693
<212>  DNA
<213>  Homo sapiens

<400>  7
atggcgagcg cctcgtacca catttccaat ttgctggaaa aaatgacatc cagcgacaag       60

gactttaggt ttatggctac aaatgatttg atgacggaac tgcagaaaga ttccatcaag      120

ttggatgatg atagtgaaag gaaagtagtg aaaatgattt tgaagttatt ggaagataaa      180

aatggagagg tacagaattt agctgtcaaa tgtcttggtc ctttagtgag taaagtgaaa      240

gaataccaag tagagacaat tgtagatacc ctctgcacta acatgctttc tgataaagaa      300

caacttcgag acatttcaag tattggtctt aaaacagtaa ttggagaact tcctccagct      360

tccagtggct ctgcattagc tgctaatgta tgtaaaaaga ttactggacg tcttacaagt      420

gcaatagcaa aacaggaaga tgtctctgtt cagctagaag ccttggatat tatggctgat      480

atgttgagca ggcaaggagg acttcttgtt aatttccatc cttcaattct gacctgtcta      540

cttccccagt tgaccagccc tagacttgca gtgaggaaaa gaaccattat cgctcttggc      600

catctggtta tgagctgtgg aaatatagtt tttgtagatc ttattgaaca tctgttgtca      660

gagttgtcca aaaatgattc tatgtcaaca acaagaacct acatacaatg tattgctgct      720

attagtaggc aagctggtca tagaataggt gaataccttg agaagataat tcctttggtg      780

gtaaaatttt gcaatgtaga tgatgatgaa ttaagagagt actgtattca agcctttgaa      840

tcatttgtaa gaagatgtcc taaggaagta tatcctcatg tttctaccat tataaatatt      900

tgtcttaaat atcttaccta tgatccaaat tataattacg atgatgaaga tgaagatgaa      960

aatgcaatgg atgctgatgg tggtgatgat gatgatcaag ggagtgatga tgaatacagt     1020

gatgatgatg acatgagttg gaaagtgaga cgtgcagctg cgaagtgctt ggatgctgta     1080

gttagcacaa ggcatgaaat gcttccagaa ttctacaaga ccgtctctcc tgcactaata     1140

tccagattta aagagcgtga agagaatgta aaggcagatg tttttcacgc atacctttct     1200

cttttgaagc aaactcgtcc tgtacaaagt tggctatgtg accctgatgc aatggagcag     1260

ggagaaacac ctttaacaat gcttcagagt caggttccca acattgttaa agctcttcac     1320

aaacagatga aagaaaaaag tgtgaagacc cgacagtgtt gttttaacat gttaactgag     1380

ctggtaaatg tattacctgg ggccctaact caacacattc ctgtacttgt accaggaatc     1440

attttctcac tgaatgataa atcaagctca tcgaatttga agatcgatgc tttgtcatgt     1500

ctatacgtaa tcctctgtaa ccattctcct caagtcttcc atcctcacgt tcaggctttg     1560

gttcctccag tggtggcttg tgttggagac ccattttaca aaattacatc tgaagcactt     1620

cttgttactc aacagcttgt caaagtaatt cgtcctttag atcagccttc ctcgtttgat     1680

gcaactcctt atatcaaaga tctatttacc tgtaccatta agagattaaa agcagctgac     1740

attgatcagg aagtcaagga aagggctatt tcctgtatgg gacaaattat ttgcaacctt     1800

ggagacaatt tgggttctga cttgcctaat acacttcaga ttttcttgga gagactaaag     1860

aatgaaatta ccaggttaac tacagtaaag gcattgacac tgattgctgg gtcacctttg     1920

aagatagatt tgaggcctgt tctgggagaa ggggttccta tccttgcttc atttcttaga     1980

aaaaaccaga gagctttgaa actgggtact ctttctgccc ttgatattct aataaaaaac     2040

tatagtgaca gcttgacagc tgccatgatt gatgcagttc tagatgagct cccacctctt     2100

atcagcgaaa gtgatatgca tgtttcacaa atggccatca gttttcttac cactttggca     2160

aaagtatatc cctcctccct ttcaaagata agtggatcca ttctcaatga acttattgga     2220

cttgtgagat cacccttatt gcagggggga gctcttagtg ccatgctaga ctttttccaa     2280

gctctggttg tcactggaac aaataattta ggatacatgg atttgttgcg catgctgact     2340

ggtccagttt actctcagag cacagctctt actcataagc agtcttatta ttccattgcc     2400

aaatgtgtag ctgcccttac tcgagcatgc cctaaagagg gaccagctgt agtaggtcag     2460

tttattcaag atgtcaagaa ctcaaggtct acagattcca ttcgtctctt agctctactt     2520

tctcttggag aagttgggca tcatattgac ttaagtggac agttggaact aaaatctgta     2580

atactagaag ctttctcatc tcctagtgaa gaagtcaaat cagctgcatc ctatgcatta     2640

ggcagcatta gtgtgggcaa ccttcctgaa tatctgccgt ttgtcctgca agaaataact     2700

agtcaaccca aaaggcagta tcttttactt cattccttga aggaaattat tagctctgca     2760

tcagtggtgg gccttaaacc atatgttgaa aacatctggg ccttattact aaagcactgt     2820

gagtgtgcag aggaaggaac cagaaatgtt gttgctgaat gtctaggaaa actcactcta     2880

attgatccag aaactctcct tccacggctt aaggggtact tgatatcagg ctcatcatat     2940

gcccgaagct cagtggttac ggctgtgaaa tttacaattt ctgaccatcc acaacctatt     3000

gatccactgt taaagaactg cataggtgat ttcctaaaaa ctttggaaga cccagatttg     3060

aatgtgagaa gagtagcctt ggtcacattt aattcagcag cacataacaa gccatcatta     3120

ataagggatc tattggatac tgttcttcca catctttaca atgaaacaaa agttagaaag     3180

gagcttataa gagaggtaga aatgggtcca tttaaacata cggttgatga tggtctggat     3240

attagaaagg cagcatttga gtgtatgtac acacttctag acagttgtct tgatagactt     3300

gatatctttg aatttctaaa tcatgttgaa gatggtttga aggaccatta tgatattaag     3360

atgctgacat ttttaatgtt ggtgagactg tctacccttt gtccaagtgc agtactgcag     3420

aggttggacc gacttgttga gccattacgt gcaacatgta caactaaggt aaaggcaaac     3480

tcagtaaagc aggagtttga aaaacaagat gaattaaagc gatctgccat gagagcagta     3540

gcagcactgc taaccattcc agaagcagag aagagtccac tgatgagtga attccagtca     3600

cagatcagtt ctaaccctga gctggcggct atctttgaaa gtatccagaa agattcatca     3660

tctactaact tggaatcaat ggacactagt tag                                  3693


<210>  8
<211>  1230
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ser Ala Ser Tyr His Ile Ser Asn Leu Leu Glu Lys Met Thr 
1               5                   10                  15      


Ser Ser Asp Lys Asp Phe Arg Phe Met Ala Thr Asn Asp Leu Met Thr 
            20                  25                  30          


Glu Leu Gln Lys Asp Ser Ile Lys Leu Asp Asp Asp Ser Glu Arg Lys 
        35                  40                  45              


Val Val Lys Met Ile Leu Lys Leu Leu Glu Asp Lys Asn Gly Glu Val 
    50                  55                  60                  


Gln Asn Leu Ala Val Lys Cys Leu Gly Pro Leu Val Ser Lys Val Lys 
65                  70                  75                  80  


Glu Tyr Gln Val Glu Thr Ile Val Asp Thr Leu Cys Thr Asn Met Leu 
                85                  90                  95      


Ser Asp Lys Glu Gln Leu Arg Asp Ile Ser Ser Ile Gly Leu Lys Thr 
            100                 105                 110         


Val Ile Gly Glu Leu Pro Pro Ala Ser Ser Gly Ser Ala Leu Ala Ala 
        115                 120                 125             


Asn Val Cys Lys Lys Ile Thr Gly Arg Leu Thr Ser Ala Ile Ala Lys 
    130                 135                 140                 


Gln Glu Asp Val Ser Val Gln Leu Glu Ala Leu Asp Ile Met Ala Asp 
145                 150                 155                 160 


Met Leu Ser Arg Gln Gly Gly Leu Leu Val Asn Phe His Pro Ser Ile 
                165                 170                 175     


Leu Thr Cys Leu Leu Pro Gln Leu Thr Ser Pro Arg Leu Ala Val Arg 
            180                 185                 190         


Lys Arg Thr Ile Ile Ala Leu Gly His Leu Val Met Ser Cys Gly Asn 
        195                 200                 205             


Ile Val Phe Val Asp Leu Ile Glu His Leu Leu Ser Glu Leu Ser Lys 
    210                 215                 220                 


Asn Asp Ser Met Ser Thr Thr Arg Thr Tyr Ile Gln Cys Ile Ala Ala 
225                 230                 235                 240 


Ile Ser Arg Gln Ala Gly His Arg Ile Gly Glu Tyr Leu Glu Lys Ile 
                245                 250                 255     


Ile Pro Leu Val Val Lys Phe Cys Asn Val Asp Asp Asp Glu Leu Arg 
            260                 265                 270         


Glu Tyr Cys Ile Gln Ala Phe Glu Ser Phe Val Arg Arg Cys Pro Lys 
        275                 280                 285             


Glu Val Tyr Pro His Val Ser Thr Ile Ile Asn Ile Cys Leu Lys Tyr 
    290                 295                 300                 


Leu Thr Tyr Asp Pro Asn Tyr Asn Tyr Asp Asp Glu Asp Glu Asp Glu 
305                 310                 315                 320 


Asn Ala Met Asp Ala Asp Gly Gly Asp Asp Asp Asp Gln Gly Ser Asp 
                325                 330                 335     


Asp Glu Tyr Ser Asp Asp Asp Asp Met Ser Trp Lys Val Arg Arg Ala 
            340                 345                 350         


Ala Ala Lys Cys Leu Asp Ala Val Val Ser Thr Arg His Glu Met Leu 
        355                 360                 365             


Pro Glu Phe Tyr Lys Thr Val Ser Pro Ala Leu Ile Ser Arg Phe Lys 
    370                 375                 380                 


Glu Arg Glu Glu Asn Val Lys Ala Asp Val Phe His Ala Tyr Leu Ser 
385                 390                 395                 400 


Leu Leu Lys Gln Thr Arg Pro Val Gln Ser Trp Leu Cys Asp Pro Asp 
                405                 410                 415     


Ala Met Glu Gln Gly Glu Thr Pro Leu Thr Met Leu Gln Ser Gln Val 
            420                 425                 430         


Pro Asn Ile Val Lys Ala Leu His Lys Gln Met Lys Glu Lys Ser Val 
        435                 440                 445             


Lys Thr Arg Gln Cys Cys Phe Asn Met Leu Thr Glu Leu Val Asn Val 
    450                 455                 460                 


Leu Pro Gly Ala Leu Thr Gln His Ile Pro Val Leu Val Pro Gly Ile 
465                 470                 475                 480 


Ile Phe Ser Leu Asn Asp Lys Ser Ser Ser Ser Asn Leu Lys Ile Asp 
                485                 490                 495     


Ala Leu Ser Cys Leu Tyr Val Ile Leu Cys Asn His Ser Pro Gln Val 
            500                 505                 510         


Phe His Pro His Val Gln Ala Leu Val Pro Pro Val Val Ala Cys Val 
        515                 520                 525             


Gly Asp Pro Phe Tyr Lys Ile Thr Ser Glu Ala Leu Leu Val Thr Gln 
    530                 535                 540                 


Gln Leu Val Lys Val Ile Arg Pro Leu Asp Gln Pro Ser Ser Phe Asp 
545                 550                 555                 560 


Ala Thr Pro Tyr Ile Lys Asp Leu Phe Thr Cys Thr Ile Lys Arg Leu 
                565                 570                 575     


Lys Ala Ala Asp Ile Asp Gln Glu Val Lys Glu Arg Ala Ile Ser Cys 
            580                 585                 590         


Met Gly Gln Ile Ile Cys Asn Leu Gly Asp Asn Leu Gly Ser Asp Leu 
        595                 600                 605             


Pro Asn Thr Leu Gln Ile Phe Leu Glu Arg Leu Lys Asn Glu Ile Thr 
    610                 615                 620                 


Arg Leu Thr Thr Val Lys Ala Leu Thr Leu Ile Ala Gly Ser Pro Leu 
625                 630                 635                 640 


Lys Ile Asp Leu Arg Pro Val Leu Gly Glu Gly Val Pro Ile Leu Ala 
                645                 650                 655     


Ser Phe Leu Arg Lys Asn Gln Arg Ala Leu Lys Leu Gly Thr Leu Ser 
            660                 665                 670         


Ala Leu Asp Ile Leu Ile Lys Asn Tyr Ser Asp Ser Leu Thr Ala Ala 
        675                 680                 685             


Met Ile Asp Ala Val Leu Asp Glu Leu Pro Pro Leu Ile Ser Glu Ser 
    690                 695                 700                 


Asp Met His Val Ser Gln Met Ala Ile Ser Phe Leu Thr Thr Leu Ala 
705                 710                 715                 720 


Lys Val Tyr Pro Ser Ser Leu Ser Lys Ile Ser Gly Ser Ile Leu Asn 
                725                 730                 735     


Glu Leu Ile Gly Leu Val Arg Ser Pro Leu Leu Gln Gly Gly Ala Leu 
            740                 745                 750         


Ser Ala Met Leu Asp Phe Phe Gln Ala Leu Val Val Thr Gly Thr Asn 
        755                 760                 765             


Asn Leu Gly Tyr Met Asp Leu Leu Arg Met Leu Thr Gly Pro Val Tyr 
    770                 775                 780                 


Ser Gln Ser Thr Ala Leu Thr His Lys Gln Ser Tyr Tyr Ser Ile Ala 
785                 790                 795                 800 


Lys Cys Val Ala Ala Leu Thr Arg Ala Cys Pro Lys Glu Gly Pro Ala 
                805                 810                 815     


Val Val Gly Gln Phe Ile Gln Asp Val Lys Asn Ser Arg Ser Thr Asp 
            820                 825                 830         


Ser Ile Arg Leu Leu Ala Leu Leu Ser Leu Gly Glu Val Gly His His 
        835                 840                 845             


Ile Asp Leu Ser Gly Gln Leu Glu Leu Lys Ser Val Ile Leu Glu Ala 
    850                 855                 860                 


Phe Ser Ser Pro Ser Glu Glu Val Lys Ser Ala Ala Ser Tyr Ala Leu 
865                 870                 875                 880 


Gly Ser Ile Ser Val Gly Asn Leu Pro Glu Tyr Leu Pro Phe Val Leu 
                885                 890                 895     


Gln Glu Ile Thr Ser Gln Pro Lys Arg Gln Tyr Leu Leu Leu His Ser 
            900                 905                 910         


Leu Lys Glu Ile Ile Ser Ser Ala Ser Val Val Gly Leu Lys Pro Tyr 
        915                 920                 925             


Val Glu Asn Ile Trp Ala Leu Leu Leu Lys His Cys Glu Cys Ala Glu 
    930                 935                 940                 


Glu Gly Thr Arg Asn Val Val Ala Glu Cys Leu Gly Lys Leu Thr Leu 
945                 950                 955                 960 


Ile Asp Pro Glu Thr Leu Leu Pro Arg Leu Lys Gly Tyr Leu Ile Ser 
                965                 970                 975     


Gly Ser Ser Tyr Ala Arg Ser Ser Val Val Thr Ala Val Lys Phe Thr 
            980                 985                 990         


Ile Ser Asp His Pro Gln Pro Ile  Asp Pro Leu Leu Lys  Asn Cys Ile 
        995                 1000                 1005             


Gly Asp  Phe Leu Lys Thr Leu  Glu Asp Pro Asp Leu  Asn Val Arg 
    1010                 1015                 1020             


Arg Val  Ala Leu Val Thr Phe  Asn Ser Ala Ala His  Asn Lys Pro 
    1025                 1030                 1035             


Ser Leu  Ile Arg Asp Leu Leu  Asp Thr Val Leu Pro  His Leu Tyr 
    1040                 1045                 1050             


Asn Glu  Thr Lys Val Arg Lys  Glu Leu Ile Arg Glu  Val Glu Met 
    1055                 1060                 1065             


Gly Pro  Phe Lys His Thr Val  Asp Asp Gly Leu Asp  Ile Arg Lys 
    1070                 1075                 1080             


Ala Ala  Phe Glu Cys Met Tyr  Thr Leu Leu Asp Ser  Cys Leu Asp 
    1085                 1090                 1095             


Arg Leu  Asp Ile Phe Glu Phe  Leu Asn His Val Glu  Asp Gly Leu 
    1100                 1105                 1110             


Lys Asp  His Tyr Asp Ile Lys  Met Leu Thr Phe Leu  Met Leu Val 
    1115                 1120                 1125             


Arg Leu  Ser Thr Leu Cys Pro  Ser Ala Val Leu Gln  Arg Leu Asp 
    1130                 1135                 1140             


Arg Leu  Val Glu Pro Leu Arg  Ala Thr Cys Thr Thr  Lys Val Lys 
    1145                 1150                 1155             


Ala Asn  Ser Val Lys Gln Glu  Phe Glu Lys Gln Asp  Glu Leu Lys 
    1160                 1165                 1170             


Arg Ser  Ala Met Arg Ala Val  Ala Ala Leu Leu Thr  Ile Pro Glu 
    1175                 1180                 1185             


Ala Glu  Lys Ser Pro Leu Met  Ser Glu Phe Gln Ser  Gln Ile Ser 
    1190                 1195                 1200             


Ser Asn  Pro Glu Leu Ala Ala  Ile Phe Glu Ser Ile  Gln Lys Asp 
    1205                 1210                 1215             


Ser Ser  Ser Thr Asn Leu Glu  Ser Met Asp Thr Ser  
    1220                 1225                 1230 


<210>  9
<211>  1302
<212>  DNA
<213>  Homo sapiens

<400>  9
atggcaacat caggtgactg tcccagaagt gaatcgcagg gagaagagcc tgctgagtgc       60

agtgaggccg gtctcctgca ggagggagta cagccagagg agtttgtggc catcgcggac      120

tacgctgcca ccgatgagac ccagctcagt tttttgagag gagaaaaaat tcttatcctg      180

agacaaacca ctgcagattg gtggtggggt gagcgtgcgg gctgctgtgg gtacattccg      240

gcaaaccatg tggggaagca cgtggatgag tacgaccccg aggacacgtg gcaggatgaa      300

gagtacttcg gcagctatgg aactctgaaa ctccacttgg agatgttggc agaccagcca      360

cgaacaacta aataccacag tgtcatcctg cagaataaag aatccctgac ggataaagtc      420

atcctggacg tgggctgtgg gactgggatc atcagtctct tctgtgcaca ctatgcgcgg      480

cctagagcgg tgtacgcggt ggaggccagt gagatggcac agcacacggg gcagctggtc      540

ctgcagaacg gctttgctga catcatcacc gtgtaccagc agaaggtgga ggatgtggtg      600

ctgcccgaga aggtggacgt gctggtgtct gagtggatgg ggacctgcct gctgtttgag      660

ttcatgatcg agtccatcct gtatgcccgg gatgcctggc tgaaggagga cggggtcatt      720

tggcccacca tggctgcgtt gcaccttgtg ccctgcagtg ctgataagga ttatcgtagc      780

aaggtgctct tctgggacaa cgcgtacgag ttcaacctca gcgctctgaa atctttagca      840

gttaaggagt ttttttcaaa gcccaagtat aaccacattt tgaaaccaga agactgtctc      900

tctgaaccgt gcactatatt gcagttggac atgagaaccg tgcaaatttc tgatctagag      960

accctgaggg gcgagctgcg cttcgacatc aggaaggcgg ggaccctgca cggcttcacg     1020

gcctggttta gcgtccactt ccagagcctg caggaggggc agccgccgca ggtgctcagc     1080

accgggccct tccaccccac cacacactgg aagcagacgc tgttcatgat ggacgaccca     1140

gtccctgtcc atacaggaga cgtggtcacg ggttcagttg tgttgcagag aaacccagtg     1200

tggagaaggc acatgtctgt ggctctgagc tgggctgtca cttccagaca agaccccaca     1260

tctcaaaaag ttggagaaaa agtcttcccc atctggagat ga                        1302


<210>  10
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Thr Ser Gly Asp Cys Pro Arg Ser Glu Ser Gln Gly Glu Glu 
1               5                   10                  15      


Pro Ala Glu Cys Ser Glu Ala Gly Leu Leu Gln Glu Gly Val Gln Pro 
            20                  25                  30          


Glu Glu Phe Val Ala Ile Ala Asp Tyr Ala Ala Thr Asp Glu Thr Gln 
        35                  40                  45              


Leu Ser Phe Leu Arg Gly Glu Lys Ile Leu Ile Leu Arg Gln Thr Thr 
    50                  55                  60                  


Ala Asp Trp Trp Trp Gly Glu Arg Ala Gly Cys Cys Gly Tyr Ile Pro 
65                  70                  75                  80  


Ala Asn His Val Gly Lys His Val Asp Glu Tyr Asp Pro Glu Asp Thr 
                85                  90                  95      


Trp Gln Asp Glu Glu Tyr Phe Gly Ser Tyr Gly Thr Leu Lys Leu His 
            100                 105                 110         


Leu Glu Met Leu Ala Asp Gln Pro Arg Thr Thr Lys Tyr His Ser Val 
        115                 120                 125             


Ile Leu Gln Asn Lys Glu Ser Leu Thr Asp Lys Val Ile Leu Asp Val 
    130                 135                 140                 


Gly Cys Gly Thr Gly Ile Ile Ser Leu Phe Cys Ala His Tyr Ala Arg 
145                 150                 155                 160 


Pro Arg Ala Val Tyr Ala Val Glu Ala Ser Glu Met Ala Gln His Thr 
                165                 170                 175     


Gly Gln Leu Val Leu Gln Asn Gly Phe Ala Asp Ile Ile Thr Val Tyr 
            180                 185                 190         


Gln Gln Lys Val Glu Asp Val Val Leu Pro Glu Lys Val Asp Val Leu 
        195                 200                 205             


Val Ser Glu Trp Met Gly Thr Cys Leu Leu Phe Glu Phe Met Ile Glu 
    210                 215                 220                 


Ser Ile Leu Tyr Ala Arg Asp Ala Trp Leu Lys Glu Asp Gly Val Ile 
225                 230                 235                 240 


Trp Pro Thr Met Ala Ala Leu His Leu Val Pro Cys Ser Ala Asp Lys 
                245                 250                 255     


Asp Tyr Arg Ser Lys Val Leu Phe Trp Asp Asn Ala Tyr Glu Phe Asn 
            260                 265                 270         


Leu Ser Ala Leu Lys Ser Leu Ala Val Lys Glu Phe Phe Ser Lys Pro 
        275                 280                 285             


Lys Tyr Asn His Ile Leu Lys Pro Glu Asp Cys Leu Ser Glu Pro Cys 
    290                 295                 300                 


Thr Ile Leu Gln Leu Asp Met Arg Thr Val Gln Ile Ser Asp Leu Glu 
305                 310                 315                 320 


Thr Leu Arg Gly Glu Leu Arg Phe Asp Ile Arg Lys Ala Gly Thr Leu 
                325                 330                 335     


His Gly Phe Thr Ala Trp Phe Ser Val His Phe Gln Ser Leu Gln Glu 
            340                 345                 350         


Gly Gln Pro Pro Gln Val Leu Ser Thr Gly Pro Phe His Pro Thr Thr 
        355                 360                 365             


His Trp Lys Gln Thr Leu Phe Met Met Asp Asp Pro Val Pro Val His 
    370                 375                 380                 


Thr Gly Asp Val Val Thr Gly Ser Val Val Leu Gln Arg Asn Pro Val 
385                 390                 395                 400 


Trp Arg Arg His Met Ser Val Ala Leu Ser Trp Ala Val Thr Ser Arg 
                405                 410                 415     


Gln Asp Pro Thr Ser Gln Lys Val Gly Glu Lys Val Phe Pro Ile Trp 
            420                 425                 430         


Arg 
    


<210>  11
<211>  855
<212>  DNA
<213>  Homo sapiens

<400>  11
atggctccgc ggctgtgcag catctctgtg acggcgcggc ggctgctggg gggcccgggg       60

cctcgcgctg gggacgttgc gtctgcagct gcggcgcgtt tctattccaa ggacaatgaa      120

ggcagctggt tccgctccct ctttgttcac aaagtggatc cccggaagga tgcccactcc      180

accctgctgt ccaagaagga aaccagcaac ctctataaga tccagtttca caatgtaaag      240

cctgaatacc tggatgccta caacagcctc acggaggctg tgctgcccaa gcttcacctg      300

gatgaggact acccatgctc actcgtgggc aactggaaca cgtggtatgg ggagcaggac      360

caggcagtgc acctgtggcg attctcaggt ggctacccag ccctcatgga ctgcatgaac      420

aagctcaaaa acaataagga gtacctggag ttccgaaggg agcggagcca gatgctgctg      480

tccaggagaa accagctgct cctcgagttc agcttctgga atgagccaca gcccagaatg      540

ggtcccaaca tctatgagct gaggacatac aagctcaagc caggaaccat gatcgagtgg      600

gggaacaact gggctcgggc catcaagtac cggcaggaga accaggaggc agtgggcggc      660

ttcttctcac agataggaga gctctacgtg gtgcaccatc tctgggccta taaagacctg      720

cagtctcggg aggagactcg aaacgctgcc tggaggaaga gaggctggga tgaaaatgtc      780

tactatacag tccccctggt gcgacacatg gagtctagga tcatgatccc cttgaagatc      840

tcgcctctgc agtga                                                       855


<210>  12
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Pro Arg Leu Cys Ser Ile Ser Val Thr Ala Arg Arg Leu Leu 
1               5                   10                  15      


Gly Gly Pro Gly Pro Arg Ala Gly Asp Val Ala Ser Ala Ala Ala Ala 
            20                  25                  30          


Arg Phe Tyr Ser Lys Asp Asn Glu Gly Ser Trp Phe Arg Ser Leu Phe 
        35                  40                  45              


Val His Lys Val Asp Pro Arg Lys Asp Ala His Ser Thr Leu Leu Ser 
    50                  55                  60                  


Lys Lys Glu Thr Ser Asn Leu Tyr Lys Ile Gln Phe His Asn Val Lys 
65                  70                  75                  80  


Pro Glu Tyr Leu Asp Ala Tyr Asn Ser Leu Thr Glu Ala Val Leu Pro 
                85                  90                  95      


Lys Leu His Leu Asp Glu Asp Tyr Pro Cys Ser Leu Val Gly Asn Trp 
            100                 105                 110         


Asn Thr Trp Tyr Gly Glu Gln Asp Gln Ala Val His Leu Trp Arg Phe 
        115                 120                 125             


Ser Gly Gly Tyr Pro Ala Leu Met Asp Cys Met Asn Lys Leu Lys Asn 
    130                 135                 140                 


Asn Lys Glu Tyr Leu Glu Phe Arg Arg Glu Arg Ser Gln Met Leu Leu 
145                 150                 155                 160 


Ser Arg Arg Asn Gln Leu Leu Leu Glu Phe Ser Phe Trp Asn Glu Pro 
                165                 170                 175     


Gln Pro Arg Met Gly Pro Asn Ile Tyr Glu Leu Arg Thr Tyr Lys Leu 
            180                 185                 190         


Lys Pro Gly Thr Met Ile Glu Trp Gly Asn Asn Trp Ala Arg Ala Ile 
        195                 200                 205             


Lys Tyr Arg Gln Glu Asn Gln Glu Ala Val Gly Gly Phe Phe Ser Gln 
    210                 215                 220                 


Ile Gly Glu Leu Tyr Val Val His His Leu Trp Ala Tyr Lys Asp Leu 
225                 230                 235                 240 


Gln Ser Arg Glu Glu Thr Arg Asn Ala Ala Trp Arg Lys Arg Gly Trp 
                245                 250                 255     


Asp Glu Asn Val Tyr Tyr Thr Val Pro Leu Val Arg His Met Glu Ser 
            260                 265                 270         


Arg Ile Met Ile Pro Leu Lys Ile Ser Pro Leu Gln 
        275                 280                 


<210>  13
<211>  3309
<212>  DNA
<213>  Homo sapiens

<400>  13
atgaaccacc agcagcagca gcagcagcag aaagcgggcg agcagcagtt gagcgagccc       60

gaggacatgg agatggaagc gggagataca gatgacccac caagaattac tcagaaccct      120

gtgatcaatg ggaatgtggc cctgagtgat ggacacaaca ccgcggagga ggacatggag      180

gatgacacca gttggcgctc cgaggcaacc tttcagttca ctgtggagcg cttcagcaga      240

ctgagtgagt cggtccttag ccctccgtgt tttgtgcgaa atctgccatg gaagattatg      300

gtgatgccac gcttttatcc agacagacca caccaaaaaa gcgtaggatt ctttctccag      360

tgcaatgctg aatctgattc cacgtcatgg tcttgccatg cacaagcagt gctgaagata      420

ataaattaca gagatgatga aaagtcgttc agtcgtcgta ttagtcattt gttcttccat      480

aaagaaaatg attggggatt ttccaatttt atggcctgga gtgaagtgac cgatcctgag      540

aaaggattta tagatgatga caaagttacc tttgaagtct ttgtacaggc ggatgctccc      600

catggagttg cgtgggattc aaagaagcac acaggctacg tcggcttaaa gaatcaggga      660

gcgacttgtt acatgaacag cctgctacag acgttatttt tcacgaatca gctacgaaag      720

gctgtgtaca tgatgccaac cgagggggat gattcgtcta aaagcgtccc tttagcatta      780

caaagagtgt tctatgaatt acagcatagt gataaacctg taggaacaaa aaagttaaca      840

aagtcatttg ggtgggaaac tttagatagc ttcatgcaac atgatgttca ggagctttgt      900

cgagtgttgc tcgataatgt ggaaaataag atgaaaggca cctgtgtaga gggcaccata      960

cccaaattat tccgcggcaa aatggtgtcc tatatccagt gtaaagaagt agactatcgg     1020

tctgatagaa gagaagatta ttatgatatc cagctaagta tcaaaggaaa gaaaaatata     1080

tttgaatcat ttgtggatta tgtggcagta gaacagctcg atggggacaa taaatacgac     1140

gctggggaac atggcttaca ggaagcagag aaaggtgtga aattcctaac attgccacca     1200

gtgttacatc tacaactgat gagatttatg tatgaccctc agacggacca aaatatcaag     1260

atcaatgata ggtttgaatt cccagagcag ttaccacttg atgaattttt gcaaaaaaca     1320

gatcctaagg accctgcaaa ttatattctt catgcagtcc tggttcatag tggagataat     1380

catggtggac attatgtggt ttatctaaac cccaaagggg atggcaaatg gtgtaaattt     1440

gatgacgacg tggtgtcaag gtgtactaaa gaggaagcaa ttgagcacaa ttatgggggt     1500

cacgatgacg acctgtctgt tcgacactgc actaatgctt acatgttagt ctacatcagg     1560

gaatcaaaac tgagtgaagt tttacaggcg gtcaccgacc atgatattcc tcagcagttg     1620

gtggagcgat tacaagaaga gaaaaggatc gaggctcaga agcggaagga gcggcaggaa     1680

gcccatctct atatgcaagt gcagatagtc gcagaggacc agttttgtgg ccaccaaggg     1740

aatgacatgt acgatgaaga aaaagtgaaa tacactgtgt tcaaagtatt gaagaactcc     1800

tcgcttgctg agtttgttca gagcctctct cagaccatgg gatttccaca agatcaaatt     1860

cgattgtggc ccatgcaagc aaggagtaat ggaacaaaac gaccagcaat gttagataat     1920

gaagccgacg gcaataaaac aatgattgag ctcagtgata atgaaaaccc ttggacaata     1980

ttcctggaaa cagttgatcc cgagctggct gctagtggag cgaccttacc caagtttgat     2040

aaagatcatg atgtaatgtt atttttgaag atgtatgatc ccaaaacgcg gagcttgaat     2100

tactgtgggc atatctacac accaatatcc tgtaaaatac gtgacttgct cccagttatg     2160

tgtgacagag caggatttat tcaagatact agccttatcc tctatgagga agttaaaccg     2220

aatttaacag agagaattca ggactatgac gtgtctcttg ataaagccct tgatgaacta     2280

atggatggtg acatcatagt atttcagaag gatgaccctg aaaatgataa cagtgaatta     2340

cccaccgcaa aggagtattt ccgagatctc taccaccgcg ttgatgtcat tttctgtgat     2400

aaaacaatcc ctaatgatcc tggatttgtg gttacgttat caaatagaat gaattatttt     2460

caggttgcaa agacagttgc acagaggctc aacacagatc caatgttgct gcagtttttc     2520

aagtctcaag gttataggga tggcccaggt aatcctctta gacataatta tgaaggtact     2580

ttaagagatc ttctacagtt cttcaagcct agacaaccta agaaacttta ctatcagcag     2640

cttaagatga aaatcacaga ctttgagaac aggcgaagtt ttaaatgtat atggttaaac     2700

agccaattta gggaagagga aataacacta tatccagaca agcatgggtg tgtccgggac     2760

ctgttagaag aatgtaaaaa ggccgtggag cttggggaga aagcatcagg gaaacttagg     2820

ctgctagaaa ttgtaagcta caaaatcatt ggtgttcatc aagaagatga actattagaa     2880

tgtttatctc ctgcaacgag ccggacgttt cgaatagagg aaatcccttt ggaccaggtg     2940

gacatagaca aagagaatga gatgcttgtc acagtggcgc atttccacaa agaggtcttc     3000

ggaacgttcg gaatcccgtt tttgctgagg atacaccagg gcgagcattt tcgagaagtg     3060

atgaagcgaa tccagagcct gctggacatc caggagaagg agtttgagaa gtttaaattt     3120

gcaattgtaa tgatgggccg acaccagtac ataaatgaag acgagtatga agtaaatttg     3180

aaagactttg agccacagcc cggtaatatg tctcatcctc ggccttggct agggctcgac     3240

cacttcaaca aagccccaaa gaggagtcgc tacacttacc ttgaaaaggc cattaaaatc     3300

cataactga                                                             3309


<210>  14
<211>  1102
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln 
1               5                   10                  15      


Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp 
            20                  25                  30          


Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu 
        35                  40                  45              


Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser 
    50                  55                  60                  


Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg 
65                  70                  75                  80  


Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro 
                85                  90                  95      


Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln 
            100                 105                 110         


Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr 
        115                 120                 125             


Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg 
    130                 135                 140                 


Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His 
145                 150                 155                 160 


Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val 
                165                 170                 175     


Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu 
            180                 185                 190         


Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys 
        195                 200                 205             


Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr 
    210                 215                 220                 


Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys 
225                 230                 235                 240 


Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val 
                245                 250                 255     


Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys 
            260                 265                 270         


Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu 
        275                 280                 285             


Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu 
    290                 295                 300                 


Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu 
                325                 330                 335     


Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu 
            340                 345                 350         


Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val 
        355                 360                 365             


Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His 
    370                 375                 380                 


Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro 
385                 390                 395                 400 


Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp 
                405                 410                 415     


Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro 
            420                 425                 430         


Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr 
        435                 440                 445             


Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His 
    450                 455                 460                 


Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe 
465                 470                 475                 480 


Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His 
                485                 490                 495     


Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn 
            500                 505                 510         


Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu 
        515                 520                 525             


Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu 
    530                 535                 540                 


Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu 
545                 550                 555                 560 


Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys 
                565                 570                 575     


Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr 
            580                 585                 590         


Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser 
        595                 600                 605             


Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro 
    610                 615                 620                 


Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn 
625                 630                 635                 640 


Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn 
                645                 650                 655     


Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser 
            660                 665                 670         


Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe 
        675                 680                 685             


Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His 
    690                 695                 700                 


Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met 
705                 710                 715                 720 


Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu 
                725                 730                 735     


Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser 
            740                 745                 750         


Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe 
        755                 760                 765             


Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys 
    770                 775                 780                 


Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp 
785                 790                 795                 800 


Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg 
                805                 810                 815     


Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr 
            820                 825                 830         


Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly 
        835                 840                 845             


Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu 
    850                 855                 860                 


Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln 
865                 870                 875                 880 


Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys 
                885                 890                 895     


Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro 
            900                 905                 910         


Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala 
        915                 920                 925             


Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile 
    930                 935                 940                 


Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu 
945                 950                 955                 960 


Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro 
                965                 970                 975     


Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val 
            980                 985                 990         


Ala His Phe His Lys Glu Val Phe  Gly Thr Phe Gly Ile  Pro Phe Leu 
        995                 1000                 1005             


Leu Arg  Ile His Gln Gly Glu  His Phe Arg Glu Val  Met Lys Arg 
    1010                 1015                 1020             


Ile Gln  Ser Leu Leu Asp Ile  Gln Glu Lys Glu Phe  Glu Lys Phe 
    1025                 1030                 1035             


Lys Phe  Ala Ile Val Met Met  Gly Arg His Gln Tyr  Ile Asn Glu 
    1040                 1045                 1050             


Asp Glu  Tyr Glu Val Asn Leu  Lys Asp Phe Glu Pro  Gln Pro Gly 
    1055                 1060                 1065             


Asn Met  Ser His Pro Arg Pro  Trp Leu Gly Leu Asp  His Phe Asn 
    1070                 1075                 1080             


Lys Ala  Pro Lys Arg Ser Arg  Tyr Thr Tyr Leu Glu  Lys Ala Ile 
    1085                 1090                 1095             


Lys Ile  His Asn 
    1100         


<210>  15
<211>  4632
<212>  DNA
<213>  Homo sapiens

<400>  15
atgtatgcag cagtggaaca tgggcctgtg ctttgcagcg attccaacat cctgtgcctg       60

tcctggaagg ggcgtgtccc caagagtgag aaggagaagc ctgtgtgcag gagacgctac      120

tatgaggaag gctggctggc cacgggcaac gggcgaggag tggttggggt gactttcacc      180

tctagtcact gtcgcaggga caggagtact ccacagagga taaatttcaa cctccggggc      240

cacaatagcg aggttgtgct ggtgaggtgg aatgagccct accagaaact ggccacgtgc      300

gatgcggacg gaggcatatt cgtgtggatt cagtacgagg gcaggtggtc tgtggagctg      360

gtcaacgacc gcggggcgca ggtgagtgat ttcacgtgga gccatgatgg aactcaagca      420

cttatttcct atcgagatgg gtttgtcctg gttgggtctg tcagtggaca aagacactgg      480

tcatccgaaa tcaacttgga aagtcaaatt acgtgtggca tatggactcc tgacgaccaa      540

caggtgctgt ttggcacggc cgatgggcag gtgattgtca tggattgcca cggcagaatg      600

ctggcccacg tcctcttgca cgagtcagac ggtgtcctcg gcatgtcctg gaactacccg      660

atcttcctgg tggaggacag cagcgagagc gacacggact cagatgacta cgcccctccc      720

caagatggtc cggcagcata tcccatccca gtgcagaaca tcaagcctct gctcaccgtc      780

agcttcacct cgggagacat cagcttaatg aacaactacg atgacttgtc tcccacggtc      840

atccgctcag ggctgaaaga ggtggtagcc cagtggtgca cacaggggga cttgctggca      900

gtcgctggga tggaacggca gacccagctt ggtgagcttc ccaatggtcc ccttctgaag      960

agtgccatgg tcaagttcta caatgttcgt ggggagcaca tcttcacact ggacactctc     1020

gtgcagcgcc ccatcatctc catctgctgg ggtcaccggg attcgaggct gttgatggca     1080

tcaggaccag ccctgtacgt ggtgcgtgtg gagcaccggg tgtccagcct gcagctgctg     1140

tgccagcagg ccatcgccag caccttgcgt gaggacaagg acgtcagcaa gctgactctg     1200

cccccccgcc tctgctccta cctctccact gccttcatcc ccaccatcaa gcccccaatt     1260

ccagatccga acaacatgag agactttgtc agctacccat cagccggcaa cgagcggctg     1320

cactgcacca tgaagcgcac agaggacgac ccggaggtgg gcggcccgtg ctacacgctc     1380

tacctggagt acctgggcgg gcttgtgccc atcctcaaag ggcggcgcat cagcaagctg     1440

cggccagagt tcgtcatcat ggacccgcgg acagatagca aaccagatga aatctatggg     1500

aacagcttga tttctactgt gatcgacagc tgcaactgct cagactccag tgacattgag     1560

ctgagtgatg actgggctgc caagaaatct cccaaaatct ccagagctag caaatcaccc     1620

aaactcccaa ggatcagcat tgaggcccgc aagtcaccca agctgccccg ggctgctcag     1680

gagctctccc ggtccccacg gttgcccctg cgcaagccct ctgtgggctc gcccagcctg     1740

actcggagag agtttccttt tgaagacatc actcagcaca actatcttgc tcaggtcacg     1800

tctaatatct ggggaaccaa atttaagatt gtgggcttgg ctgctttcct gccaaccaac     1860

ctcggtgcag taatctataa aaccagcctc ctgcatctcc agccgcggca gatgaccatt     1920

tatctcccag aagttcggaa aatttccatg gactatatta atttacctgt cttcaaccca     1980

aatgttttca gtgaagatga agatgattta ccagtgacag gagcatctgg tgtccctgag     2040

aacagcccac cttgtaccgt gaacatccct attgcaccga tccacagctc ggctcaggct     2100

atgtccccca cgcagagcat agggctggtg cagtccctac tggccaatca gaatgtgcag     2160

ctagatgtcc tgaccaacca gacgacagct gtagggacag cagaacatgc aggtgacagt     2220

gccacccagt acccagtctc caaccggtac tccaatcctg gacaggtgat tttcggaagc     2280

gtggaaatgg gccgcatcat tcagaacccc cctccactgt ccctgcctcc cccgccgcag     2340

gggcccatgc agctgtccac ggtgggccat ggagaccgag accacgaaca cctgcagaag     2400

tcagccaagg ccctgcggcc aacaccgcag ctggcagctg agggggacgc agtggtcttt     2460

agtgcccccc aggaggtcca ggtgacgaag ataaaccctc cacccccgta cccaggaacc     2520

atccccgctg cccccaccac agcagcaccc ccgccccctc tgccgccccc acagccccca     2580

gtggatgtgt gcttgaagaa gggcgacttc tccctctacc ccacgtcagt gcactaccag     2640

acccccctgg gctatgagag gatcaccacc ttcgacagca gtggcaacgt ggaggaggtg     2700

tgccggcccc gcacccggat gctgtgctcc cagaacacgt acaccctccc cggcccgggt     2760

agctctgcca ccttgaggct cacggccact gagaagaagg tccctcagcc ctgcagcagt     2820

gccaccctga accgcctgac cgtccctcgc tactccatcc ccaccgggga cccacccccg     2880

tatcctgaaa ttgccagcca gctggcccag gggcgggggg ctgcccagag gtccgacaat     2940

agcctcatcc acgctaccct gcggaggaac aaccgtgagg ctacgctcaa gatggcccag     3000

ctggccgaca gcccgcgggc ccccctgcag cccctggcca agtccaaggg cgggcccggg     3060

ggggtggtga cacagctccc agcgcggccc ccacctgccc tgtacacctg cagtcagtgc     3120

agtggcacag ggcccagctc acagcccgga gcctccctgg cccataccgc cagcgcctcc     3180

ccgttggcct cccagtcctc ctacagcctc ctgagcccac ccgacagcgc ccgcgaccgc     3240

accgactacg tcaactcggc cttcacggag gacgaggccc tgtcccagca ctgtcagctt     3300

gagaagccct tgaggcaccc tcccctgcct gaagctgctg tcaccctgaa acggccaccc     3360

ccttaccagt gggaccccat gctgggtgag gatgtttggg ttcctcaaga aaggacagca     3420

cagacttcag ggcccaaccc cttaaaactg tcctctctga tgctgagtca gggccagcac     3480

ctggacgtgt cccgactgcc cttcatctcc cccaagtctc ctgccagccc cactgccact     3540

ttccaaacag gctatgggat gggagtgcca tatccaggaa gctataacaa cccccctttg     3600

cctggagtgc aggctccctg ctctcccaaa gatgccctgt ccccaacgca gtttgcacaa     3660

caggagcctg ctgtggtcct tcagccgctg tacccaccca gcctctccta ttgcaccctg     3720

ccccccatgt acccaggaag cagcacgtgc tctagtttac agctgccacc tgtcgccttg     3780

catccatgga gttcctacag cgcctgcccg cccatgcaga acccccaggg cactctcccc     3840

ccaaagccac acttggtggt ggagaagccc cttgtgtccc caccacctgc cgacctccaa     3900

agccacttgg gcacagaggt gatggtagag actgcagaca acttccagga agtcctctcc     3960

ctgaccgaaa gcccagtccc ccagcggaca gaaaaatttg gaaagaagaa ccggaagcgc     4020

ctggacagcc gagcagaaga aggcagcgtt caggccatca ctgagggcaa agtgaagaag     4080

gaggctagga ctttgagtga ctttaattcc ctaatctcca gcccacacct ggggagagag     4140

aagaagaaag tgaagagtca gaaagaccaa ctgaagtcaa agaagttgaa taagacaaac     4200

gagttccagg acagctccga gagcgagcct gagctgttca tcagcgggga tgagctcatg     4260

aaccagagcc agggcagcag aaagggctgg aaaagcaagc gctccccacg ggccgccggc     4320

gagctggagg aggccaagtg ccggcgggcc agtgagaagg aggacgggcg gctgggcagc     4380

caaggcttcg tgtacgtgat ggccaacaag cagccgctgt ggaacgaggc cacccaggtc     4440

taccagctgg acttcggggg gcgggtgacc caggagtccg ccaagaactt ccagattgag     4500

ttagaggggc ggcaggtgat gcagtttgga cggattgatg gcagtgcgta cattctagac     4560

ttccagtatc cgttctcagc cgtgcaggcc tttgcagttg ccctggccaa cgtgactcag     4620

cgcctcaaat ga                                                         4632


<210>  16
<211>  1543
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Tyr Ala Ala Val Glu His Gly Pro Val Leu Cys Ser Asp Ser Asn 
1               5                   10                  15      


Ile Leu Cys Leu Ser Trp Lys Gly Arg Val Pro Lys Ser Glu Lys Glu 
            20                  25                  30          


Lys Pro Val Cys Arg Arg Arg Tyr Tyr Glu Glu Gly Trp Leu Ala Thr 
        35                  40                  45              


Gly Asn Gly Arg Gly Val Val Gly Val Thr Phe Thr Ser Ser His Cys 
    50                  55                  60                  


Arg Arg Asp Arg Ser Thr Pro Gln Arg Ile Asn Phe Asn Leu Arg Gly 
65                  70                  75                  80  


His Asn Ser Glu Val Val Leu Val Arg Trp Asn Glu Pro Tyr Gln Lys 
                85                  90                  95      


Leu Ala Thr Cys Asp Ala Asp Gly Gly Ile Phe Val Trp Ile Gln Tyr 
            100                 105                 110         


Glu Gly Arg Trp Ser Val Glu Leu Val Asn Asp Arg Gly Ala Gln Val 
        115                 120                 125             


Ser Asp Phe Thr Trp Ser His Asp Gly Thr Gln Ala Leu Ile Ser Tyr 
    130                 135                 140                 


Arg Asp Gly Phe Val Leu Val Gly Ser Val Ser Gly Gln Arg His Trp 
145                 150                 155                 160 


Ser Ser Glu Ile Asn Leu Glu Ser Gln Ile Thr Cys Gly Ile Trp Thr 
                165                 170                 175     


Pro Asp Asp Gln Gln Val Leu Phe Gly Thr Ala Asp Gly Gln Val Ile 
            180                 185                 190         


Val Met Asp Cys His Gly Arg Met Leu Ala His Val Leu Leu His Glu 
        195                 200                 205             


Ser Asp Gly Val Leu Gly Met Ser Trp Asn Tyr Pro Ile Phe Leu Val 
    210                 215                 220                 


Glu Asp Ser Ser Glu Ser Asp Thr Asp Ser Asp Asp Tyr Ala Pro Pro 
225                 230                 235                 240 


Gln Asp Gly Pro Ala Ala Tyr Pro Ile Pro Val Gln Asn Ile Lys Pro 
                245                 250                 255     


Leu Leu Thr Val Ser Phe Thr Ser Gly Asp Ile Ser Leu Met Asn Asn 
            260                 265                 270         


Tyr Asp Asp Leu Ser Pro Thr Val Ile Arg Ser Gly Leu Lys Glu Val 
        275                 280                 285             


Val Ala Gln Trp Cys Thr Gln Gly Asp Leu Leu Ala Val Ala Gly Met 
    290                 295                 300                 


Glu Arg Gln Thr Gln Leu Gly Glu Leu Pro Asn Gly Pro Leu Leu Lys 
305                 310                 315                 320 


Ser Ala Met Val Lys Phe Tyr Asn Val Arg Gly Glu His Ile Phe Thr 
                325                 330                 335     


Leu Asp Thr Leu Val Gln Arg Pro Ile Ile Ser Ile Cys Trp Gly His 
            340                 345                 350         


Arg Asp Ser Arg Leu Leu Met Ala Ser Gly Pro Ala Leu Tyr Val Val 
        355                 360                 365             


Arg Val Glu His Arg Val Ser Ser Leu Gln Leu Leu Cys Gln Gln Ala 
    370                 375                 380                 


Ile Ala Ser Thr Leu Arg Glu Asp Lys Asp Val Ser Lys Leu Thr Leu 
385                 390                 395                 400 


Pro Pro Arg Leu Cys Ser Tyr Leu Ser Thr Ala Phe Ile Pro Thr Ile 
                405                 410                 415     


Lys Pro Pro Ile Pro Asp Pro Asn Asn Met Arg Asp Phe Val Ser Tyr 
            420                 425                 430         


Pro Ser Ala Gly Asn Glu Arg Leu His Cys Thr Met Lys Arg Thr Glu 
        435                 440                 445             


Asp Asp Pro Glu Val Gly Gly Pro Cys Tyr Thr Leu Tyr Leu Glu Tyr 
    450                 455                 460                 


Leu Gly Gly Leu Val Pro Ile Leu Lys Gly Arg Arg Ile Ser Lys Leu 
465                 470                 475                 480 


Arg Pro Glu Phe Val Ile Met Asp Pro Arg Thr Asp Ser Lys Pro Asp 
                485                 490                 495     


Glu Ile Tyr Gly Asn Ser Leu Ile Ser Thr Val Ile Asp Ser Cys Asn 
            500                 505                 510         


Cys Ser Asp Ser Ser Asp Ile Glu Leu Ser Asp Asp Trp Ala Ala Lys 
        515                 520                 525             


Lys Ser Pro Lys Ile Ser Arg Ala Ser Lys Ser Pro Lys Leu Pro Arg 
    530                 535                 540                 


Ile Ser Ile Glu Ala Arg Lys Ser Pro Lys Leu Pro Arg Ala Ala Gln 
545                 550                 555                 560 


Glu Leu Ser Arg Ser Pro Arg Leu Pro Leu Arg Lys Pro Ser Val Gly 
                565                 570                 575     


Ser Pro Ser Leu Thr Arg Arg Glu Phe Pro Phe Glu Asp Ile Thr Gln 
            580                 585                 590         


His Asn Tyr Leu Ala Gln Val Thr Ser Asn Ile Trp Gly Thr Lys Phe 
        595                 600                 605             


Lys Ile Val Gly Leu Ala Ala Phe Leu Pro Thr Asn Leu Gly Ala Val 
    610                 615                 620                 


Ile Tyr Lys Thr Ser Leu Leu His Leu Gln Pro Arg Gln Met Thr Ile 
625                 630                 635                 640 


Tyr Leu Pro Glu Val Arg Lys Ile Ser Met Asp Tyr Ile Asn Leu Pro 
                645                 650                 655     


Val Phe Asn Pro Asn Val Phe Ser Glu Asp Glu Asp Asp Leu Pro Val 
            660                 665                 670         


Thr Gly Ala Ser Gly Val Pro Glu Asn Ser Pro Pro Cys Thr Val Asn 
        675                 680                 685             


Ile Pro Ile Ala Pro Ile His Ser Ser Ala Gln Ala Met Ser Pro Thr 
    690                 695                 700                 


Gln Ser Ile Gly Leu Val Gln Ser Leu Leu Ala Asn Gln Asn Val Gln 
705                 710                 715                 720 


Leu Asp Val Leu Thr Asn Gln Thr Thr Ala Val Gly Thr Ala Glu His 
                725                 730                 735     


Ala Gly Asp Ser Ala Thr Gln Tyr Pro Val Ser Asn Arg Tyr Ser Asn 
            740                 745                 750         


Pro Gly Gln Val Ile Phe Gly Ser Val Glu Met Gly Arg Ile Ile Gln 
        755                 760                 765             


Asn Pro Pro Pro Leu Ser Leu Pro Pro Pro Pro Gln Gly Pro Met Gln 
    770                 775                 780                 


Leu Ser Thr Val Gly His Gly Asp Arg Asp His Glu His Leu Gln Lys 
785                 790                 795                 800 


Ser Ala Lys Ala Leu Arg Pro Thr Pro Gln Leu Ala Ala Glu Gly Asp 
                805                 810                 815     


Ala Val Val Phe Ser Ala Pro Gln Glu Val Gln Val Thr Lys Ile Asn 
            820                 825                 830         


Pro Pro Pro Pro Tyr Pro Gly Thr Ile Pro Ala Ala Pro Thr Thr Ala 
        835                 840                 845             


Ala Pro Pro Pro Pro Leu Pro Pro Pro Gln Pro Pro Val Asp Val Cys 
    850                 855                 860                 


Leu Lys Lys Gly Asp Phe Ser Leu Tyr Pro Thr Ser Val His Tyr Gln 
865                 870                 875                 880 


Thr Pro Leu Gly Tyr Glu Arg Ile Thr Thr Phe Asp Ser Ser Gly Asn 
                885                 890                 895     


Val Glu Glu Val Cys Arg Pro Arg Thr Arg Met Leu Cys Ser Gln Asn 
            900                 905                 910         


Thr Tyr Thr Leu Pro Gly Pro Gly Ser Ser Ala Thr Leu Arg Leu Thr 
        915                 920                 925             


Ala Thr Glu Lys Lys Val Pro Gln Pro Cys Ser Ser Ala Thr Leu Asn 
    930                 935                 940                 


Arg Leu Thr Val Pro Arg Tyr Ser Ile Pro Thr Gly Asp Pro Pro Pro 
945                 950                 955                 960 


Tyr Pro Glu Ile Ala Ser Gln Leu Ala Gln Gly Arg Gly Ala Ala Gln 
                965                 970                 975     


Arg Ser Asp Asn Ser Leu Ile His Ala Thr Leu Arg Arg Asn Asn Arg 
            980                 985                 990         


Glu Ala Thr Leu Lys Met Ala Gln  Leu Ala Asp Ser Pro  Arg Ala Pro 
        995                 1000                 1005             


Leu Gln  Pro Leu Ala Lys Ser  Lys Gly Gly Pro Gly  Gly Val Val 
    1010                 1015                 1020             


Thr Gln  Leu Pro Ala Arg Pro  Pro Pro Ala Leu Tyr  Thr Cys Ser 
    1025                 1030                 1035             


Gln Cys  Ser Gly Thr Gly Pro  Ser Ser Gln Pro Gly  Ala Ser Leu 
    1040                 1045                 1050             


Ala His  Thr Ala Ser Ala Ser  Pro Leu Ala Ser Gln  Ser Ser Tyr 
    1055                 1060                 1065             


Ser Leu  Leu Ser Pro Pro Asp  Ser Ala Arg Asp Arg  Thr Asp Tyr 
    1070                 1075                 1080             


Val Asn  Ser Ala Phe Thr Glu  Asp Glu Ala Leu Ser  Gln His Cys 
    1085                 1090                 1095             


Gln Leu  Glu Lys Pro Leu Arg  His Pro Pro Leu Pro  Glu Ala Ala 
    1100                 1105                 1110             


Val Thr  Leu Lys Arg Pro Pro  Pro Tyr Gln Trp Asp  Pro Met Leu 
    1115                 1120                 1125             


Gly Glu  Asp Val Trp Val Pro  Gln Glu Arg Thr Ala  Gln Thr Ser 
    1130                 1135                 1140             


Gly Pro  Asn Pro Leu Lys Leu  Ser Ser Leu Met Leu  Ser Gln Gly 
    1145                 1150                 1155             


Gln His  Leu Asp Val Ser Arg  Leu Pro Phe Ile Ser  Pro Lys Ser 
    1160                 1165                 1170             


Pro Ala  Ser Pro Thr Ala Thr  Phe Gln Thr Gly Tyr  Gly Met Gly 
    1175                 1180                 1185             


Val Pro  Tyr Pro Gly Ser Tyr  Asn Asn Pro Pro Leu  Pro Gly Val 
    1190                 1195                 1200             


Gln Ala  Pro Cys Ser Pro Lys  Asp Ala Leu Ser Pro  Thr Gln Phe 
    1205                 1210                 1215             


Ala Gln  Gln Glu Pro Ala Val  Val Leu Gln Pro Leu  Tyr Pro Pro 
    1220                 1225                 1230             


Ser Leu  Ser Tyr Cys Thr Leu  Pro Pro Met Tyr Pro  Gly Ser Ser 
    1235                 1240                 1245             


Thr Cys  Ser Ser Leu Gln Leu  Pro Pro Val Ala Leu  His Pro Trp 
    1250                 1255                 1260             


Ser Ser  Tyr Ser Ala Cys Pro  Pro Met Gln Asn Pro  Gln Gly Thr 
    1265                 1270                 1275             


Leu Pro  Pro Lys Pro His Leu  Val Val Glu Lys Pro  Leu Val Ser 
    1280                 1285                 1290             


Pro Pro  Pro Ala Asp Leu Gln  Ser His Leu Gly Thr  Glu Val Met 
    1295                 1300                 1305             


Val Glu  Thr Ala Asp Asn Phe  Gln Glu Val Leu Ser  Leu Thr Glu 
    1310                 1315                 1320             


Ser Pro  Val Pro Gln Arg Thr  Glu Lys Phe Gly Lys  Lys Asn Arg 
    1325                 1330                 1335             


Lys Arg  Leu Asp Ser Arg Ala  Glu Glu Gly Ser Val  Gln Ala Ile 
    1340                 1345                 1350             


Thr Glu  Gly Lys Val Lys Lys  Glu Ala Arg Thr Leu  Ser Asp Phe 
    1355                 1360                 1365             


Asn Ser  Leu Ile Ser Ser Pro  His Leu Gly Arg Glu  Lys Lys Lys 
    1370                 1375                 1380             


Val Lys  Ser Gln Lys Asp Gln  Leu Lys Ser Lys Lys  Leu Asn Lys 
    1385                 1390                 1395             


Thr Asn  Glu Phe Gln Asp Ser  Ser Glu Ser Glu Pro  Glu Leu Phe 
    1400                 1405                 1410             


Ile Ser  Gly Asp Glu Leu Met  Asn Gln Ser Gln Gly  Ser Arg Lys 
    1415                 1420                 1425             


Gly Trp  Lys Ser Lys Arg Ser  Pro Arg Ala Ala Gly  Glu Leu Glu 
    1430                 1435                 1440             


Glu Ala  Lys Cys Arg Arg Ala  Ser Glu Lys Glu Asp  Gly Arg Leu 
    1445                 1450                 1455             


Gly Ser  Gln Gly Phe Val Tyr  Val Met Ala Asn Lys  Gln Pro Leu 
    1460                 1465                 1470             


Trp Asn  Glu Ala Thr Gln Val  Tyr Gln Leu Asp Phe  Gly Gly Arg 
    1475                 1480                 1485             


Val Thr  Gln Glu Ser Ala Lys  Asn Phe Gln Ile Glu  Leu Glu Gly 
    1490                 1495                 1500             


Arg Gln  Val Met Gln Phe Gly  Arg Ile Asp Gly Ser  Ala Tyr Ile 
    1505                 1510                 1515             


Leu Asp  Phe Gln Tyr Pro Phe  Ser Ala Val Gln Ala  Phe Ala Val 
    1520                 1525                 1530             


Ala Leu  Ala Asn Val Thr Gln  Arg Leu Lys 
    1535                 1540             


<210>  17
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  17
atggcctcca acaaaactac attgcaaaaa atgggaaaaa aacagaatgg aaagagtaaa       60

aaagttgaag aggcagagcc tgaagaattt gtcgtggaaa aagtactaga tcgacgtgta      120

gtgaatggga aagtggaata tttcctgaag tggaagggat ttacagatgc tgacaatact      180

tgggaacctg aagaaaattt agattgtcca gaattgattg aagcgtttct taactctcag      240

aaagctggca aagaaaaaga tggtacaaaa agaaaatctt tatctgacag tgaatctgat      300

gacagcaaat caaagaagaa aagagatgct gctgacaaac caagaggatt tgccagaggt      360

cttgatcctg aaagaataat tggtgccaca gacagcagtg gagaattgat gtttctcatg      420

aaatggaaag attcagatga ggcagacttg gtgctggcga aagaggcaaa tatgaagtgt      480

cctcaaattg taattgcttt ttatgaagag agactaactt ggcattcttg tccagaagat      540

gaagctcaat aa                                                          552


<210>  18
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210>  19
<211>  1743
<212>  DNA
<213>  Homo sapiens

<400>  19
atgttcgcgg ggctgcagga cctgggcgtg gccaacggcg aggacctgaa ggagaccctg       60

accaactgca cggagccgct caaggccatc gagcagttcc agacagagaa tggtgtgctg      120

ctgccatctc ttcagtcagc cctccccttc ttggacctgc acgggacgcc gcggctggag      180

ttccaccagt cggtattcga tgagctgcgg gacaagctgc tggagcgagt gtcagccatc      240

gcttcggagg ggaaggctga ggaaaggtac aagaagctgg aagaccttct ggagaagagc      300

ttttctctgg tgaagatgcc gtccctgcag cccgtggtga tgtgcgtcat gaagcacctg      360

cccaaggttc cggagaaaaa actgaagctg gttatggctg acaaggagct gtatcgagcc      420

tgcgccgtgg aggtgaagcg gcagatctgg caagacaacc aggccctctt cggggacgag      480

gtttccccac tcctgaagca gtacatcctg gagaaggaga gcgctctctt cagtacagag      540

ctctctgtcc tgcacaactt tttcagtcct tcccccaaga ccaggcgcca gggcgaggtg      600

gtgcagcggc tgacgcggat ggtggggaag aacgtgaagc tgtacgacat ggtgctgcag      660

tttctgcgca cgctcttcct gcgcacgcgg aatgtgcact actgcacgct gcgggctgag      720

ctgctcatgt ccctgcacga cctggacgtg ggtgaaatct gcaccgtgga cccgtgccac      780

aagttcacct ggtgcctgga cgcctgcatc cgagagcggt tcgtggacag caagagggcg      840

cgggagctgc aggggtttct cgatggcgtc aagaagggcc aggagcaggt gctgggggac      900

ctgtccatga tcctgtgtga ccccttcgcc atcaacacgc tggcactgag cacagtcagg      960

cacctgcagg agctggtcgg ccaggagaca ctgcccaggg acagccccga cctcctgctg     1020

ctgctccggc tgctggcgct gggccaggga gcctgggaca tgatcgacag ccaggtcttc     1080

aaggagccca agatggaggt agagctcatc accaggttcc tcccgatgct catgtccttc     1140

ctggtggatg actacacttt caatgtggat cagaaacttc cggctgagga gaaagcccca     1200

gtctcatatc caaacacact tcccgaaagc ttcactaagt ttctgcagga gcagcgcatg     1260

gcctgcgagg tggggctgta ctacgtcctg cacatcacca agcagaggaa caagaacgcg     1320

ctcctccgcc tgctgcccgg gctggtggag acctttggcg acttggcctt tggcgacatc     1380

ttcctccacc tgctcacggg caaccttgcg ctgctggccg acgaatttgc ccttgaggac     1440

ttctgcagca gcctcttcga tggcttcttc ctcaccgcct ctccaaggaa ggagaacgtg     1500

caccggcacg cgctgcggct cctcattcac ctgcacccca gggtggcccc gtctaagctg     1560

gaggcgttgc agaaggccct ggagcctaca ggccagagcg gagaggcagt gaaggagctt     1620

tactcccagc tcggcgagaa gctggaacag ctggatcacc ggaagcccag cccggcacag     1680

gctgcggaga cgccggccct ggagctgccc ctccccagcg tgcccgcccc tgccccgctc     1740

tga                                                                   1743


<210>  20
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Phe Ala Gly Leu Gln Asp Leu Gly Val Ala Asn Gly Glu Asp Leu 
1               5                   10                  15      


Lys Glu Thr Leu Thr Asn Cys Thr Glu Pro Leu Lys Ala Ile Glu Gln 
            20                  25                  30          


Phe Gln Thr Glu Asn Gly Val Leu Leu Pro Ser Leu Gln Ser Ala Leu 
        35                  40                  45              


Pro Phe Leu Asp Leu His Gly Thr Pro Arg Leu Glu Phe His Gln Ser 
    50                  55                  60                  


Val Phe Asp Glu Leu Arg Asp Lys Leu Leu Glu Arg Val Ser Ala Ile 
65                  70                  75                  80  


Ala Ser Glu Gly Lys Ala Glu Glu Arg Tyr Lys Lys Leu Glu Asp Leu 
                85                  90                  95      


Leu Glu Lys Ser Phe Ser Leu Val Lys Met Pro Ser Leu Gln Pro Val 
            100                 105                 110         


Val Met Cys Val Met Lys His Leu Pro Lys Val Pro Glu Lys Lys Leu 
        115                 120                 125             


Lys Leu Val Met Ala Asp Lys Glu Leu Tyr Arg Ala Cys Ala Val Glu 
    130                 135                 140                 


Val Lys Arg Gln Ile Trp Gln Asp Asn Gln Ala Leu Phe Gly Asp Glu 
145                 150                 155                 160 


Val Ser Pro Leu Leu Lys Gln Tyr Ile Leu Glu Lys Glu Ser Ala Leu 
                165                 170                 175     


Phe Ser Thr Glu Leu Ser Val Leu His Asn Phe Phe Ser Pro Ser Pro 
            180                 185                 190         


Lys Thr Arg Arg Gln Gly Glu Val Val Gln Arg Leu Thr Arg Met Val 
        195                 200                 205             


Gly Lys Asn Val Lys Leu Tyr Asp Met Val Leu Gln Phe Leu Arg Thr 
    210                 215                 220                 


Leu Phe Leu Arg Thr Arg Asn Val His Tyr Cys Thr Leu Arg Ala Glu 
225                 230                 235                 240 


Leu Leu Met Ser Leu His Asp Leu Asp Val Gly Glu Ile Cys Thr Val 
                245                 250                 255     


Asp Pro Cys His Lys Phe Thr Trp Cys Leu Asp Ala Cys Ile Arg Glu 
            260                 265                 270         


Arg Phe Val Asp Ser Lys Arg Ala Arg Glu Leu Gln Gly Phe Leu Asp 
        275                 280                 285             


Gly Val Lys Lys Gly Gln Glu Gln Val Leu Gly Asp Leu Ser Met Ile 
    290                 295                 300                 


Leu Cys Asp Pro Phe Ala Ile Asn Thr Leu Ala Leu Ser Thr Val Arg 
305                 310                 315                 320 


His Leu Gln Glu Leu Val Gly Gln Glu Thr Leu Pro Arg Asp Ser Pro 
                325                 330                 335     


Asp Leu Leu Leu Leu Leu Arg Leu Leu Ala Leu Gly Gln Gly Ala Trp 
            340                 345                 350         


Asp Met Ile Asp Ser Gln Val Phe Lys Glu Pro Lys Met Glu Val Glu 
        355                 360                 365             


Leu Ile Thr Arg Phe Leu Pro Met Leu Met Ser Phe Leu Val Asp Asp 
    370                 375                 380                 


Tyr Thr Phe Asn Val Asp Gln Lys Leu Pro Ala Glu Glu Lys Ala Pro 
385                 390                 395                 400 


Val Ser Tyr Pro Asn Thr Leu Pro Glu Ser Phe Thr Lys Phe Leu Gln 
                405                 410                 415     


Glu Gln Arg Met Ala Cys Glu Val Gly Leu Tyr Tyr Val Leu His Ile 
            420                 425                 430         


Thr Lys Gln Arg Asn Lys Asn Ala Leu Leu Arg Leu Leu Pro Gly Leu 
        435                 440                 445             


Val Glu Thr Phe Gly Asp Leu Ala Phe Gly Asp Ile Phe Leu His Leu 
    450                 455                 460                 


Leu Thr Gly Asn Leu Ala Leu Leu Ala Asp Glu Phe Ala Leu Glu Asp 
465                 470                 475                 480 


Phe Cys Ser Ser Leu Phe Asp Gly Phe Phe Leu Thr Ala Ser Pro Arg 
                485                 490                 495     


Lys Glu Asn Val His Arg His Ala Leu Arg Leu Leu Ile His Leu His 
            500                 505                 510         


Pro Arg Val Ala Pro Ser Lys Leu Glu Ala Leu Gln Lys Ala Leu Glu 
        515                 520                 525             


Pro Thr Gly Gln Ser Gly Glu Ala Val Lys Glu Leu Tyr Ser Gln Leu 
    530                 535                 540                 


Gly Glu Lys Leu Glu Gln Leu Asp His Arg Lys Pro Ser Pro Ala Gln 
545                 550                 555                 560 


Ala Ala Glu Thr Pro Ala Leu Glu Leu Pro Leu Pro Ser Val Pro Ala 
                565                 570                 575     


Pro Ala Pro Leu 
            580 


<210>  21
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  21
atggctgtag tacctctgct gttgttgggg ggtttgtgga gcgctgtggg agcgtccagc       60

ctgggtgtcg ttacttgcgg ctccgtggtg aagctactca atacgcgcca caacgtccga      120

ctgcactcac acgacgtgcg ctatgggtca ggtagtgggc agcagtcagt gacaggtgta      180

acctctgtgg atgacagcaa cagttactgg aggatacggg ggaagagtgc cacagtgtgt      240

gagaggggaa cccccatcaa gtgtggccag cccatccggc tgacacatgt caacactggc      300

cgaaacctcc atagtcacca cttcacttca cctctttctg gaaaccagga agtgagtgct      360

tttggtgagg aaggtgaagg tgattatctg gatgactgga cagtgctctg taatggaccc      420

tactgggtga gagatggtga ggtgcggttc aaacactctt ccactgaggt actgctgtct      480

gtcacaggag aacaatatgg tcgacctatc agtgggcaaa aagaggtgca tggcatggcc      540

cagccaagtc agaacaacta ctggaaagcc atggaaggca tcttcatgaa gcccagtgag      600

ttgttgaagg cagaagccca ccatgcagag ctgtga                                636


<210>  22
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Val Val Pro Leu Leu Leu Leu Gly Gly Leu Trp Ser Ala Val 
1               5                   10                  15      


Gly Ala Ser Ser Leu Gly Val Val Thr Cys Gly Ser Val Val Lys Leu 
            20                  25                  30          


Leu Asn Thr Arg His Asn Val Arg Leu His Ser His Asp Val Arg Tyr 
        35                  40                  45              


Gly Ser Gly Ser Gly Gln Gln Ser Val Thr Gly Val Thr Ser Val Asp 
    50                  55                  60                  


Asp Ser Asn Ser Tyr Trp Arg Ile Arg Gly Lys Ser Ala Thr Val Cys 
65                  70                  75                  80  


Glu Arg Gly Thr Pro Ile Lys Cys Gly Gln Pro Ile Arg Leu Thr His 
                85                  90                  95      


Val Asn Thr Gly Arg Asn Leu His Ser His His Phe Thr Ser Pro Leu 
            100                 105                 110         


Ser Gly Asn Gln Glu Val Ser Ala Phe Gly Glu Glu Gly Glu Gly Asp 
        115                 120                 125             


Tyr Leu Asp Asp Trp Thr Val Leu Cys Asn Gly Pro Tyr Trp Val Arg 
    130                 135                 140                 


Asp Gly Glu Val Arg Phe Lys His Ser Ser Thr Glu Val Leu Leu Ser 
145                 150                 155                 160 


Val Thr Gly Glu Gln Tyr Gly Arg Pro Ile Ser Gly Gln Lys Glu Val 
                165                 170                 175     


His Gly Met Ala Gln Pro Ser Gln Asn Asn Tyr Trp Lys Ala Met Glu 
            180                 185                 190         


Gly Ile Phe Met Lys Pro Ser Glu Leu Leu Lys Ala Glu Ala His His 
        195                 200                 205             


Ala Glu Leu 
    210     


<210>  23
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  23
atggcggcca tggagaccga gacggcgccg ctgaccctag agtcgctgcc caccgatccc       60

ctgctcctca tcttatcctt tttggactat cgggatctaa tcaactgttg ttatgtcagt      120

cgaagactta gccagctatc aagtcatgat ccgctgtgga gaagacattg caaaaaatac      180

tggctgatat ctgaggaaga gaaaacacag aagaatcagt gttggaaatc tctcttcata      240

gatacttact ctgatgtagg aagatacatt gaccattatg ctgctattaa aaaggcctgg      300

gatgatctca agaaatattt ggagcccagg tgtcctcgga tggttttatc tctgaaagag      360

ggtgctcgag aggaagacct cgatgctgtg gaagcgcaga ttggctgcaa gcttcctgac      420

gattatcgat gttcataccg aattcacaat ggacagaagt tagtggttcc tgggttattg      480

ggaagcatgg cactgtctaa tcactatcgt tctgaagatt tgttagacgt cgatacagct      540

gccggaggat tccagcagag acagggactg aaatactgtc tccctttaac tttttgcata      600

catactggtt tgagtcagta catagcagtg gaagctgcag agggccgaaa caaaaatgaa      660

gttttctacc aatgtccaga ccaaatggct cgaaatccag ctgctattga catgtttatt      720

ataggtgcta cttttactga ctggtttacc tcttatgtca aaaatgttgt atcaggtggc      780

ttccccatca tcagagacca aattttcaga tatgttcacg atccagaatg tgtagcaaca      840

actggggata ttactgtgtc agtttccaca tcgtttctgc cagaacttag ctctgtacat      900

ccaccccact atttcttcac ataccgaatc aggattgaaa tgtcaaaaga tgcacttcct      960

gagaaggcct gtcagttgga cagtcgctat tggagaataa caaatgctaa gggtgacgtg     1020

gaagaagttc aaggacctgg agtagttggt gaatttccaa tcatcagccc aggtcgggta     1080

tatgaataca caagctgtac cacattctct acaacatcag gatacatgga aggatattat     1140

accttccatt ttctttactt taaagacaag atctttaatg ttgccattcc ccgattccat     1200

atggcatgtc caacattcag ggtgtctata gcccgattgg taagttaa                  1248


<210>  24
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ala Met Glu Thr Glu Thr Ala Pro Leu Thr Leu Glu Ser Leu 
1               5                   10                  15      


Pro Thr Asp Pro Leu Leu Leu Ile Leu Ser Phe Leu Asp Tyr Arg Asp 
            20                  25                  30          


Leu Ile Asn Cys Cys Tyr Val Ser Arg Arg Leu Ser Gln Leu Ser Ser 
        35                  40                  45              


His Asp Pro Leu Trp Arg Arg His Cys Lys Lys Tyr Trp Leu Ile Ser 
    50                  55                  60                  


Glu Glu Glu Lys Thr Gln Lys Asn Gln Cys Trp Lys Ser Leu Phe Ile 
65                  70                  75                  80  


Asp Thr Tyr Ser Asp Val Gly Arg Tyr Ile Asp His Tyr Ala Ala Ile 
                85                  90                  95      


Lys Lys Ala Trp Asp Asp Leu Lys Lys Tyr Leu Glu Pro Arg Cys Pro 
            100                 105                 110         


Arg Met Val Leu Ser Leu Lys Glu Gly Ala Arg Glu Glu Asp Leu Asp 
        115                 120                 125             


Ala Val Glu Ala Gln Ile Gly Cys Lys Leu Pro Asp Asp Tyr Arg Cys 
    130                 135                 140                 


Ser Tyr Arg Ile His Asn Gly Gln Lys Leu Val Val Pro Gly Leu Leu 
145                 150                 155                 160 


Gly Ser Met Ala Leu Ser Asn His Tyr Arg Ser Glu Asp Leu Leu Asp 
                165                 170                 175     


Val Asp Thr Ala Ala Gly Gly Phe Gln Gln Arg Gln Gly Leu Lys Tyr 
            180                 185                 190         


Cys Leu Pro Leu Thr Phe Cys Ile His Thr Gly Leu Ser Gln Tyr Ile 
        195                 200                 205             


Ala Val Glu Ala Ala Glu Gly Arg Asn Lys Asn Glu Val Phe Tyr Gln 
    210                 215                 220                 


Cys Pro Asp Gln Met Ala Arg Asn Pro Ala Ala Ile Asp Met Phe Ile 
225                 230                 235                 240 


Ile Gly Ala Thr Phe Thr Asp Trp Phe Thr Ser Tyr Val Lys Asn Val 
                245                 250                 255     


Val Ser Gly Gly Phe Pro Ile Ile Arg Asp Gln Ile Phe Arg Tyr Val 
            260                 265                 270         


His Asp Pro Glu Cys Val Ala Thr Thr Gly Asp Ile Thr Val Ser Val 
        275                 280                 285             


Ser Thr Ser Phe Leu Pro Glu Leu Ser Ser Val His Pro Pro His Tyr 
    290                 295                 300                 


Phe Phe Thr Tyr Arg Ile Arg Ile Glu Met Ser Lys Asp Ala Leu Pro 
305                 310                 315                 320 


Glu Lys Ala Cys Gln Leu Asp Ser Arg Tyr Trp Arg Ile Thr Asn Ala 
                325                 330                 335     


Lys Gly Asp Val Glu Glu Val Gln Gly Pro Gly Val Val Gly Glu Phe 
            340                 345                 350         


Pro Ile Ile Ser Pro Gly Arg Val Tyr Glu Tyr Thr Ser Cys Thr Thr 
        355                 360                 365             


Phe Ser Thr Thr Ser Gly Tyr Met Glu Gly Tyr Tyr Thr Phe His Phe 
    370                 375                 380                 


Leu Tyr Phe Lys Asp Lys Ile Phe Asn Val Ala Ile Pro Arg Phe His 
385                 390                 395                 400 


Met Ala Cys Pro Thr Phe Arg Val Ser Ile Ala Arg Leu Val Ser 
                405                 410                 415 


<210>  25
<211>  1014
<212>  DNA
<213>  Homo sapiens

<400>  25
atggggctgg ggctgctgct cccgctgctg ctgctctgga ctcgggggac tcaggggtcc       60

gagctggacc ccaaagggca gcacgtctgt gtggccagca gcccctctgc tgagctgcag      120

tgctgcgcag gctggaggca gaaggatcaa gaatgcacca tccccatctg tgaggggccg      180

gacgcctgcc agaaagacga ggtgtgtgtg aagccgggcc tctgtcgatg caagcctgga      240

ttctttgggg cccactgcag ctcccgctgc ccgggccagt actggggccc cgactgccgt      300

gagagctgcc cctgccaccc gcacggccag tgcgagccag ccacgggcgc gtgccagtgc      360

caggccgacc gctggggagc ccgctgcgag ttcccgtgcg cctgcggccc ccacgggcgc      420

tgcgaccccg cgaccggcgt gtgccactgc gaacccggct ggtggtcgtc cacgtgccgc      480

cgcccgtgcc agtgcaacac cgcggcggcg cgctgcgagc aggccacggg cgcctgcgtg      540

tgcaagccgg gctggtgggg gcgccgctgc agcttccgct gcaactgcca cggctccccg      600

tgcgagcagg actccggccg ctgcgcctgc cggccgggct ggtggggtcc cgaatgccag      660

cagcagtgcg agtgtgtgcg gggccgctgc agcgccgcct ccggcgagtg cacctgcccg      720

cccggcttcc gcggagcgcg ctgcgagctg ccctgcccgg caggcagcca cggggtgcag      780

tgcgcacaca gctgtggccg ctgcaaacac aatgagccgt gctctccaga cacaggcagc      840

tgtgagtcct gcgagccggg ctggaacggg acccagtgcc agcagccctg cctgcctggc      900

acctttggcg agagctgcga acagcagtgc cctcactgcc gacatgggga ggcctgtgag      960

ccagatactg gccactgtca gcgctgtgac cctggctggc tggggcccag gtga           1014


<210>  26
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Leu Gly Leu Leu Leu Pro Leu Leu Leu Leu Trp Thr Arg Gly 
1               5                   10                  15      


Thr Gln Gly Ser Glu Leu Asp Pro Lys Gly Gln His Val Cys Val Ala 
            20                  25                  30          


Ser Ser Pro Ser Ala Glu Leu Gln Cys Cys Ala Gly Trp Arg Gln Lys 
        35                  40                  45              


Asp Gln Glu Cys Thr Ile Pro Ile Cys Glu Gly Pro Asp Ala Cys Gln 
    50                  55                  60                  


Lys Asp Glu Val Cys Val Lys Pro Gly Leu Cys Arg Cys Lys Pro Gly 
65                  70                  75                  80  


Phe Phe Gly Ala His Cys Ser Ser Arg Cys Pro Gly Gln Tyr Trp Gly 
                85                  90                  95      


Pro Asp Cys Arg Glu Ser Cys Pro Cys His Pro His Gly Gln Cys Glu 
            100                 105                 110         


Pro Ala Thr Gly Ala Cys Gln Cys Gln Ala Asp Arg Trp Gly Ala Arg 
        115                 120                 125             


Cys Glu Phe Pro Cys Ala Cys Gly Pro His Gly Arg Cys Asp Pro Ala 
    130                 135                 140                 


Thr Gly Val Cys His Cys Glu Pro Gly Trp Trp Ser Ser Thr Cys Arg 
145                 150                 155                 160 


Arg Pro Cys Gln Cys Asn Thr Ala Ala Ala Arg Cys Glu Gln Ala Thr 
                165                 170                 175     


Gly Ala Cys Val Cys Lys Pro Gly Trp Trp Gly Arg Arg Cys Ser Phe 
            180                 185                 190         


Arg Cys Asn Cys His Gly Ser Pro Cys Glu Gln Asp Ser Gly Arg Cys 
        195                 200                 205             


Ala Cys Arg Pro Gly Trp Trp Gly Pro Glu Cys Gln Gln Gln Cys Glu 
    210                 215                 220                 


Cys Val Arg Gly Arg Cys Ser Ala Ala Ser Gly Glu Cys Thr Cys Pro 
225                 230                 235                 240 


Pro Gly Phe Arg Gly Ala Arg Cys Glu Leu Pro Cys Pro Ala Gly Ser 
                245                 250                 255     


His Gly Val Gln Cys Ala His Ser Cys Gly Arg Cys Lys His Asn Glu 
            260                 265                 270         


Pro Cys Ser Pro Asp Thr Gly Ser Cys Glu Ser Cys Glu Pro Gly Trp 
        275                 280                 285             


Asn Gly Thr Gln Cys Gln Gln Pro Cys Leu Pro Gly Thr Phe Gly Glu 
    290                 295                 300                 


Ser Cys Glu Gln Gln Cys Pro His Cys Arg His Gly Glu Ala Cys Glu 
305                 310                 315                 320 


Pro Asp Thr Gly His Cys Gln Arg Cys Asp Pro Gly Trp Leu Gly Pro 
                325                 330                 335     


Arg 
    


<210>  27
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  27
atggacatga tgctgttggt gcagggtgct tgttgctcga accagtggct ggcggcggtg       60

ctcctcagcc tgtgctgcct gctaccctcc tgcctcccgg ctggacagag tgtggacttc      120

ccctgggcgg ccgtggacaa catgatggtc agaaaagggg acacggcggt gcttaggtgt      180

tatttggaag atggagcttc aaagggtgcc tggctgaacc ggtcaagtat tatttttgcg      240

ggaggtgata agtggtcagt ggatcctcga gtttcaattt caacattgaa taaaagggac      300

tacagcctcc agatacagaa tgtagatgtg acagatgatg gcccatacac gtgttctgtt      360

cagactcaac atacacccag aacaatgcag gtgcatctaa ctgtgcaagt tcctcctaag      420

atatatgaca tctcaaatga tatgaccgtc aatgaaggaa ccaacgtcac tcttacttgt      480

ttggccactg ggaaaccaga gccttccatt tcttggcgac acatctcccc atcagcaaaa      540

ccatttgaaa atggacaata tttggacatt tatggaatta caagggacca ggctggggaa      600

tatgaatgca gtgcggaaaa tgatgtgtca ttcccagatg tgaggaaagt aaaagttgtt      660

gtcaactttg ctcctactat tcaggaaatt aaatctggca ccgtgacccc cggacgcagt      720

ggcctgataa gatgtgaagg tgcaggtgtg ccgcctccag cctttgaatg gtacaaagga      780

gagaagaagc tcttcaatgg ccaacaagga attattattc aaaattttag cacaagatcc      840

attctcactg ttaccaacgt gacacaggag cacttcggca attatacctg tgtggctgcc      900

aacaagctag gcacaaccaa tgcgagcctg cctcttaacc ctccaagtac agcccagtat      960

ggaattaccg ggagcgctga tgttcttttc tcctgctggt accttgtgtt gacactgtcc     1020

tctttcacca gcatattcta cctgaagaat gccattctac aataa                     1065


<210>  28
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Met Met Leu Leu Val Gln Gly Ala Cys Cys Ser Asn Gln Trp 
1               5                   10                  15      


Leu Ala Ala Val Leu Leu Ser Leu Cys Cys Leu Leu Pro Ser Cys Leu 
            20                  25                  30          


Pro Ala Gly Gln Ser Val Asp Phe Pro Trp Ala Ala Val Asp Asn Met 
        35                  40                  45              


Met Val Arg Lys Gly Asp Thr Ala Val Leu Arg Cys Tyr Leu Glu Asp 
    50                  55                  60                  


Gly Ala Ser Lys Gly Ala Trp Leu Asn Arg Ser Ser Ile Ile Phe Ala 
65                  70                  75                  80  


Gly Gly Asp Lys Trp Ser Val Asp Pro Arg Val Ser Ile Ser Thr Leu 
                85                  90                  95      


Asn Lys Arg Asp Tyr Ser Leu Gln Ile Gln Asn Val Asp Val Thr Asp 
            100                 105                 110         


Asp Gly Pro Tyr Thr Cys Ser Val Gln Thr Gln His Thr Pro Arg Thr 
        115                 120                 125             


Met Gln Val His Leu Thr Val Gln Val Pro Pro Lys Ile Tyr Asp Ile 
    130                 135                 140                 


Ser Asn Asp Met Thr Val Asn Glu Gly Thr Asn Val Thr Leu Thr Cys 
145                 150                 155                 160 


Leu Ala Thr Gly Lys Pro Glu Pro Ser Ile Ser Trp Arg His Ile Ser 
                165                 170                 175     


Pro Ser Ala Lys Pro Phe Glu Asn Gly Gln Tyr Leu Asp Ile Tyr Gly 
            180                 185                 190         


Ile Thr Arg Asp Gln Ala Gly Glu Tyr Glu Cys Ser Ala Glu Asn Asp 
        195                 200                 205             


Val Ser Phe Pro Asp Val Arg Lys Val Lys Val Val Val Asn Phe Ala 
    210                 215                 220                 


Pro Thr Ile Gln Glu Ile Lys Ser Gly Thr Val Thr Pro Gly Arg Ser 
225                 230                 235                 240 


Gly Leu Ile Arg Cys Glu Gly Ala Gly Val Pro Pro Pro Ala Phe Glu 
                245                 250                 255     


Trp Tyr Lys Gly Glu Lys Lys Leu Phe Asn Gly Gln Gln Gly Ile Ile 
            260                 265                 270         


Ile Gln Asn Phe Ser Thr Arg Ser Ile Leu Thr Val Thr Asn Val Thr 
        275                 280                 285             


Gln Glu His Phe Gly Asn Tyr Thr Cys Val Ala Ala Asn Lys Leu Gly 
    290                 295                 300                 


Thr Thr Asn Ala Ser Leu Pro Leu Asn Pro Pro Ser Thr Ala Gln Tyr 
305                 310                 315                 320 


Gly Ile Thr Gly Ser Ala Asp Val Leu Phe Ser Cys Trp Tyr Leu Val 
                325                 330                 335     


Leu Thr Leu Ser Ser Phe Thr Ser Ile Phe Tyr Leu Lys Asn Ala Ile 
            340                 345                 350         


Leu Gln 
        


<210>  29
<211>  858
<212>  DNA
<213>  Homo sapiens

<400>  29
atgctttatc tcatcgggtt gggcctggga gatgccaagg acatcacagt caagggcctg       60

gaagttgtta gacgctgcag tcgagtgtat ctggaagcct acacctcagt cctaactgta      120

gggaaggaag ccttggaaga gttttatgga agaaaattgg ttgttgctga tagagaagaa      180

gtggaacaag aagcagataa tattttaaag gatgctgata tcagtgatgt tgcattcctt      240

gtggttggtg atccatttgg ggccacaaca cacagtgatc ttgttctaag agcaacaaag      300

ctgggaattc cttatagagt tattcacaat gcctccataa tgaatgctgt aggctgctgt      360

ggtttacagt tatataagtt tggagagaca gtttctattg ttttttggac agacacttgg      420

agaccagaaa gcttctttga caaagtgaag aagaacagac aaaatggcat gcacacatta      480

tgtttactag acatcaaagt aaaggagcag tctttggaaa atctaatcaa gggaaggaag      540

atctatgaac ctccacggta tatgagtgta aaccaagcag cccagcagct tctggagatt      600

gttcaaaatc aaagaatacg aggagaagaa ccagcagtta ccgaggagac actttgtgtt      660

ggcttagcca gggttggagc cgacgaccag aaaattgcag caggcacttt aaggcaaatg      720

tgcactgtgg acttgggaga accattgcat tccttgatca tcacaggagg cagcatacat      780

ccaatggaga tggagatgct aagtctgttt tccataccag aaaatagctc agaatctcaa      840

agcatcaatg gactttga                                                    858


<210>  30
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Tyr Leu Ile Gly Leu Gly Leu Gly Asp Ala Lys Asp Ile Thr 
1               5                   10                  15      


Val Lys Gly Leu Glu Val Val Arg Arg Cys Ser Arg Val Tyr Leu Glu 
            20                  25                  30          


Ala Tyr Thr Ser Val Leu Thr Val Gly Lys Glu Ala Leu Glu Glu Phe 
        35                  40                  45              


Tyr Gly Arg Lys Leu Val Val Ala Asp Arg Glu Glu Val Glu Gln Glu 
    50                  55                  60                  


Ala Asp Asn Ile Leu Lys Asp Ala Asp Ile Ser Asp Val Ala Phe Leu 
65                  70                  75                  80  


Val Val Gly Asp Pro Phe Gly Ala Thr Thr His Ser Asp Leu Val Leu 
                85                  90                  95      


Arg Ala Thr Lys Leu Gly Ile Pro Tyr Arg Val Ile His Asn Ala Ser 
            100                 105                 110         


Ile Met Asn Ala Val Gly Cys Cys Gly Leu Gln Leu Tyr Lys Phe Gly 
        115                 120                 125             


Glu Thr Val Ser Ile Val Phe Trp Thr Asp Thr Trp Arg Pro Glu Ser 
    130                 135                 140                 


Phe Phe Asp Lys Val Lys Lys Asn Arg Gln Asn Gly Met His Thr Leu 
145                 150                 155                 160 


Cys Leu Leu Asp Ile Lys Val Lys Glu Gln Ser Leu Glu Asn Leu Ile 
                165                 170                 175     


Lys Gly Arg Lys Ile Tyr Glu Pro Pro Arg Tyr Met Ser Val Asn Gln 
            180                 185                 190         


Ala Ala Gln Gln Leu Leu Glu Ile Val Gln Asn Gln Arg Ile Arg Gly 
        195                 200                 205             


Glu Glu Pro Ala Val Thr Glu Glu Thr Leu Cys Val Gly Leu Ala Arg 
    210                 215                 220                 


Val Gly Ala Asp Asp Gln Lys Ile Ala Ala Gly Thr Leu Arg Gln Met 
225                 230                 235                 240 


Cys Thr Val Asp Leu Gly Glu Pro Leu His Ser Leu Ile Ile Thr Gly 
                245                 250                 255     


Gly Ser Ile His Pro Met Glu Met Glu Met Leu Ser Leu Phe Ser Ile 
            260                 265                 270         


Pro Glu Asn Ser Ser Glu Ser Gln Ser Ile Asn Gly Leu 
        275                 280                 285 


<210>  31
<211>  2295
<212>  DNA
<213>  Homo sapiens

<400>  31
atgtcggata cgcggcggcg agtgaaggtc tataccctga acgaagaccg gcaatgggac       60

gaccgaggca ccgggcacgt ctcctccact tacgtggagg agctcaaggg gatgtcgctg      120

ctggttcggg cagagtccga cggatcacta ctcttggaat caaagataaa tccaaatact      180

gcatatcaga aacaacagga tacattaatt gtttggtcag aagcagagaa ctatgatttg      240

gctctgagtt ttcaggagaa agctggctgt gatgagatct gggaaaaaat ttgtcaggtt      300

caaggtaaag acccatcagt ggaagtcaca caggacctca ttgatgaatc tgaagaagaa      360

cgatttgaag aaatgcctga aactagtcat ctgattgacc tgcccacatg tgaactcaat      420

aaacttgaag agattgctga cttagttacc tcagtgctct cctcacctat ccgtagggaa      480

aagctggctc tcgccttgga aaatgaaggc tatattaaaa aactattgca gctgttccaa      540

gcttgcgaga acctagaaaa cactgaaggc ttacaccatt tgtatgaaat tattagagga      600

atcttattcc taaataaggc aactcttttt gaggtaatgt tttctgatga gtgtatcatg      660

gatgtcgtgg gatgccttga atatgaccct gctttggctc agccaaaaag acatagagaa      720

ttcttgacca aaactgcaaa gttcaaggaa gttataccaa taacagactc tgaactaagg      780

caaaaaatac atcagactta cagggtacag tacattcagg acatcatttt gcccacacca      840

tctgtttttg aagagaattt tctttctact cttacgtctt ttattttctt caacaaagtt      900

gagatagtca gcatgttgca ggaagatgag aagtttttgt ctgaagtttt tgcacaatta      960

acagatgagg ctacagatga tgataaacgg cgtgaattgg ttaatttttt caaggagttt     1020

tgtgcatttt ctcagacatt acaacctcaa aacagggatg catttttcaa aacattggca     1080

aaattgggaa ttcttcctgc tcttgaaatt gtaatgggca tggatgattt gcaagtcaga     1140

tcagctgcta cagatatatt ttcttatcta gtagaattta gtccatctat ggtccgagag     1200

tttgtaatgc aagaagctca gcagagtgat gacgatattc ttcttattaa tgtggtaatt     1260

gaacaaatga tctgtgatac tgatcctgag ctaggaggcg ctgttcagtt aatgggactt     1320

cttcgtactc taattgatcc agagaacatg ctggctacaa ctaataaaac cgaaaaaagt     1380

gaatttctaa attttttcta caaccattgt atgcatgttc tcacagcacc acttttgacc     1440

aatacttcag aagacaaatg tgaaaaggat aatatagttg gatcaaacaa aaacaacaca     1500

atttgtcccg gtgcccttcg ctttatgagg cggataattg gacttaaaga tgaattttat     1560

aatcgttaca tcaccaaggg aaatcttttt gagccagtta taaatgcact tctggataat     1620

ggaactcggt ataatctgtt gaattcagct gttattgagt tgtttgaatt tataagagtg     1680

gaagatatca agtctcttac tgcccatata gttgaaaact tttataaagc acttgaatcg     1740

attgaatatg ttcagacatt caaaggattg aagactaaat atgagcaaga aaaagacaga     1800

caaaatcaga aactgaacag tgtaccatct atattgcgta gtaacagatt tcgcagagat     1860

gcaaaagcct tggaagagga tgaagaaatg tggtttaatg aagatgaaga agaggaagga     1920

aaagcagttg tggcaccagt ggaaaaacct aagccagaag atgattttcc agataattat     1980

gaaaagttta tggagactaa aaaagcaaaa gaaagtgaag acaaggaaaa ccttcccaaa     2040

aggacatctc ctggtggctt caaatttact ttctcccact ctgccagtgc tgctaatgga     2100

acaaacagta aatctgtagt ggctcagata ccaccagcaa cttctaatgg atcctcttcc     2160

aaaaccacaa acttgcctac gtcagtaaca gccaccaagg gaagtttggt tggcttagtg     2220

gattatccag atgatgaaga ggaagatgaa gaagaagaat cgtcccccag gaaaagacct     2280

cgtcttggct cataa                                                      2295


<210>  32
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp 
1               5                   10                  15      


Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Thr Tyr Val 
            20                  25                  30          


Glu Glu Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly 
        35                  40                  45              


Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys 
    50                  55                  60                  


Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys 
                85                  90                  95      


Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Glu Val Thr Gln Asp 
            100                 105                 110         


Leu Ile Asp Glu Ser Glu Glu Glu Arg Phe Glu Glu Met Pro Glu Thr 
        115                 120                 125             


Ser His Leu Ile Asp Leu Pro Thr Cys Glu Leu Asn Lys Leu Glu Glu 
    130                 135                 140                 


Ile Ala Asp Leu Val Thr Ser Val Leu Ser Ser Pro Ile Arg Arg Glu 
145                 150                 155                 160 


Lys Leu Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu 
                165                 170                 175     


Gln Leu Phe Gln Ala Cys Glu Asn Leu Glu Asn Thr Glu Gly Leu His 
            180                 185                 190         


His Leu Tyr Glu Ile Ile Arg Gly Ile Leu Phe Leu Asn Lys Ala Thr 
        195                 200                 205             


Leu Phe Glu Val Met Phe Ser Asp Glu Cys Ile Met Asp Val Val Gly 
    210                 215                 220                 


Cys Leu Glu Tyr Asp Pro Ala Leu Ala Gln Pro Lys Arg His Arg Glu 
225                 230                 235                 240 


Phe Leu Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Thr Asp 
                245                 250                 255     


Ser Glu Leu Arg Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile 
            260                 265                 270         


Gln Asp Ile Ile Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Phe Leu 
        275                 280                 285             


Ser Thr Leu Thr Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Ser 
    290                 295                 300                 


Met Leu Gln Glu Asp Glu Lys Phe Leu Ser Glu Val Phe Ala Gln Leu 
305                 310                 315                 320 


Thr Asp Glu Ala Thr Asp Asp Asp Lys Arg Arg Glu Leu Val Asn Phe 
                325                 330                 335     


Phe Lys Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg 
            340                 345                 350         


Asp Ala Phe Phe Lys Thr Leu Ala Lys Leu Gly Ile Leu Pro Ala Leu 
        355                 360                 365             


Glu Ile Val Met Gly Met Asp Asp Leu Gln Val Arg Ser Ala Ala Thr 
    370                 375                 380                 


Asp Ile Phe Ser Tyr Leu Val Glu Phe Ser Pro Ser Met Val Arg Glu 
385                 390                 395                 400 


Phe Val Met Gln Glu Ala Gln Gln Ser Asp Asp Asp Ile Leu Leu Ile 
                405                 410                 415     


Asn Val Val Ile Glu Gln Met Ile Cys Asp Thr Asp Pro Glu Leu Gly 
            420                 425                 430         


Gly Ala Val Gln Leu Met Gly Leu Leu Arg Thr Leu Ile Asp Pro Glu 
        435                 440                 445             


Asn Met Leu Ala Thr Thr Asn Lys Thr Glu Lys Ser Glu Phe Leu Asn 
    450                 455                 460                 


Phe Phe Tyr Asn His Cys Met His Val Leu Thr Ala Pro Leu Leu Thr 
465                 470                 475                 480 


Asn Thr Ser Glu Asp Lys Cys Glu Lys Asp Asn Ile Val Gly Ser Asn 
                485                 490                 495     


Lys Asn Asn Thr Ile Cys Pro Gly Ala Leu Arg Phe Met Arg Arg Ile 
            500                 505                 510         


Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr Ile Thr Lys Gly Asn 
        515                 520                 525             


Leu Phe Glu Pro Val Ile Asn Ala Leu Leu Asp Asn Gly Thr Arg Tyr 
    530                 535                 540                 


Asn Leu Leu Asn Ser Ala Val Ile Glu Leu Phe Glu Phe Ile Arg Val 
545                 550                 555                 560 


Glu Asp Ile Lys Ser Leu Thr Ala His Ile Val Glu Asn Phe Tyr Lys 
                565                 570                 575     


Ala Leu Glu Ser Ile Glu Tyr Val Gln Thr Phe Lys Gly Leu Lys Thr 
            580                 585                 590         


Lys Tyr Glu Gln Glu Lys Asp Arg Gln Asn Gln Lys Leu Asn Ser Val 
        595                 600                 605             


Pro Ser Ile Leu Arg Ser Asn Arg Phe Arg Arg Asp Ala Lys Ala Leu 
    610                 615                 620                 


Glu Glu Asp Glu Glu Met Trp Phe Asn Glu Asp Glu Glu Glu Glu Gly 
625                 630                 635                 640 


Lys Ala Val Val Ala Pro Val Glu Lys Pro Lys Pro Glu Asp Asp Phe 
                645                 650                 655     


Pro Asp Asn Tyr Glu Lys Phe Met Glu Thr Lys Lys Ala Lys Glu Ser 
            660                 665                 670         


Glu Asp Lys Glu Asn Leu Pro Lys Arg Thr Ser Pro Gly Gly Phe Lys 
        675                 680                 685             


Phe Thr Phe Ser His Ser Ala Ser Ala Ala Asn Gly Thr Asn Ser Lys 
    690                 695                 700                 


Ser Val Val Ala Gln Ile Pro Pro Ala Thr Ser Asn Gly Ser Ser Ser 
705                 710                 715                 720 


Lys Thr Thr Asn Leu Pro Thr Ser Val Thr Ala Thr Lys Gly Ser Leu 
                725                 730                 735     


Val Gly Leu Val Asp Tyr Pro Asp Asp Glu Glu Glu Asp Glu Glu Glu 
            740                 745                 750         


Glu Ser Ser Pro Arg Lys Arg Pro Arg Leu Gly Ser 
        755                 760                 


<210>  33
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400>  33
atggcggagg cttcttttgg aagttcgagc ccagttgggt ctttgtcttc tgaggatcat       60

gattttgacc ccactgctga gatgttggtc catgactatg atgatgaaag aactcttgaa      120

gaagaggaaa tgatggatga gggtaaaaac ttcagttcag aaattgaaga cttagaaaag      180

gaaggaacca tgcctctaga agatttactg gcattctatg gctatgaacc tacaattcca      240

gcagttgcaa attccagtgc aaatagttcc ccaagtgaac tggcagatga actaccagac      300

atgacactag acaaagagga aatagcaaaa gacctgttgt caggtgatga cgaggaaact      360

cagtcttctg cggatgatct gacgccatct gtgacttccc atgaaacttc tgatttcttc      420

cctaggcctt tacgatcaaa tactgcatgt gatggtgata aggaatcaga ggttgaagat      480

gttgaaacag acagtggtaa ttcacctgaa gatttgagga aggaaataat gattggttta      540

caatatcagg cagagattcc cccttatctt ggagagtacg atggtaatga gaaagtatat      600

gaaaacgaag accagttact ttggtgtcct gatgtggttt tggagagcaa agttaaggaa      660

taccttgttg agacttcatt aaggactggc agtgaaaaaa taatggatag gatttctgca      720

ggaacacaca caagggacaa tgaacaggca ttatatgaac ttctcaagtg taaccacaat      780

ataaaggaag caatcgaaag atactgctgc aatggaaagg cctctcaagg aatgactgca      840

tggacggaag aagaatgccg aagctttgaa catgcactca tgctttttgg aaaagatttt      900

catcttatac agaagaataa ggtgagaact aggacagttg ctgagtgtgt agcattctac      960

tatatgtgga agaaatctga acgttatgat tactttgctc aacagacaag atttgggaaa     1020

aaaagatata accatcaccc tggagttacg gactatatgg atcgtttagt agatgaaaca     1080

gaagctttgg gtgggacggt aaatgcttca gccttaactt ctaaccggcc tgagcctatt     1140

cctgatcaac agctaaacat tctcaactcc ttcactgcca gtgacttgac agctttgacc     1200

aacagtgtag caaccgtctg cgaccccaca gatgtgaatt gtttggatga tagctttcct     1260

ccactgggca acacaccccg tggacaagtt aatcatgtgc ctgttgtaac agaagagtta     1320

ctcaccctgc ccagcaatgg ggaaagtgat tgttttaatt tatttgagac tggattttat     1380

cactcggagc taaaccctat gaacatgtgc agtgaagagt cagagagacc agcaaaaaga     1440

ttgaaaatgg gcattgccgt ccctgaatcc tttatgaatg aagtttctgt aaataacctg     1500

ggtgtggact ttgaaaatca cacacatcac atcaccagtg ccaaaatggc tgtttctgtg     1560

gctgactttg gcagtctctc tgccaacgag accaatggtt tcatcagtgc ccatgctctg     1620

catcagcacg cggccctaca ctctgagtga                                      1650


<210>  34
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Glu Ala Ser Phe Gly Ser Ser Ser Pro Val Gly Ser Leu Ser 
1               5                   10                  15      


Ser Glu Asp His Asp Phe Asp Pro Thr Ala Glu Met Leu Val His Asp 
            20                  25                  30          


Tyr Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu Met Met Asp Glu Gly 
        35                  40                  45              


Lys Asn Phe Ser Ser Glu Ile Glu Asp Leu Glu Lys Glu Gly Thr Met 
    50                  55                  60                  


Pro Leu Glu Asp Leu Leu Ala Phe Tyr Gly Tyr Glu Pro Thr Ile Pro 
65                  70                  75                  80  


Ala Val Ala Asn Ser Ser Ala Asn Ser Ser Pro Ser Glu Leu Ala Asp 
                85                  90                  95      


Glu Leu Pro Asp Met Thr Leu Asp Lys Glu Glu Ile Ala Lys Asp Leu 
            100                 105                 110         


Leu Ser Gly Asp Asp Glu Glu Thr Gln Ser Ser Ala Asp Asp Leu Thr 
        115                 120                 125             


Pro Ser Val Thr Ser His Glu Thr Ser Asp Phe Phe Pro Arg Pro Leu 
    130                 135                 140                 


Arg Ser Asn Thr Ala Cys Asp Gly Asp Lys Glu Ser Glu Val Glu Asp 
145                 150                 155                 160 


Val Glu Thr Asp Ser Gly Asn Ser Pro Glu Asp Leu Arg Lys Glu Ile 
                165                 170                 175     


Met Ile Gly Leu Gln Tyr Gln Ala Glu Ile Pro Pro Tyr Leu Gly Glu 
            180                 185                 190         


Tyr Asp Gly Asn Glu Lys Val Tyr Glu Asn Glu Asp Gln Leu Leu Trp 
        195                 200                 205             


Cys Pro Asp Val Val Leu Glu Ser Lys Val Lys Glu Tyr Leu Val Glu 
    210                 215                 220                 


Thr Ser Leu Arg Thr Gly Ser Glu Lys Ile Met Asp Arg Ile Ser Ala 
225                 230                 235                 240 


Gly Thr His Thr Arg Asp Asn Glu Gln Ala Leu Tyr Glu Leu Leu Lys 
                245                 250                 255     


Cys Asn His Asn Ile Lys Glu Ala Ile Glu Arg Tyr Cys Cys Asn Gly 
            260                 265                 270         


Lys Ala Ser Gln Gly Met Thr Ala Trp Thr Glu Glu Glu Cys Arg Ser 
        275                 280                 285             


Phe Glu His Ala Leu Met Leu Phe Gly Lys Asp Phe His Leu Ile Gln 
    290                 295                 300                 


Lys Asn Lys Val Arg Thr Arg Thr Val Ala Glu Cys Val Ala Phe Tyr 
305                 310                 315                 320 


Tyr Met Trp Lys Lys Ser Glu Arg Tyr Asp Tyr Phe Ala Gln Gln Thr 
                325                 330                 335     


Arg Phe Gly Lys Lys Arg Tyr Asn His His Pro Gly Val Thr Asp Tyr 
            340                 345                 350         


Met Asp Arg Leu Val Asp Glu Thr Glu Ala Leu Gly Gly Thr Val Asn 
        355                 360                 365             


Ala Ser Ala Leu Thr Ser Asn Arg Pro Glu Pro Ile Pro Asp Gln Gln 
    370                 375                 380                 


Leu Asn Ile Leu Asn Ser Phe Thr Ala Ser Asp Leu Thr Ala Leu Thr 
385                 390                 395                 400 


Asn Ser Val Ala Thr Val Cys Asp Pro Thr Asp Val Asn Cys Leu Asp 
                405                 410                 415     


Asp Ser Phe Pro Pro Leu Gly Asn Thr Pro Arg Gly Gln Val Asn His 
            420                 425                 430         


Val Pro Val Val Thr Glu Glu Leu Leu Thr Leu Pro Ser Asn Gly Glu 
        435                 440                 445             


Ser Asp Cys Phe Asn Leu Phe Glu Thr Gly Phe Tyr His Ser Glu Leu 
    450                 455                 460                 


Asn Pro Met Asn Met Cys Ser Glu Glu Ser Glu Arg Pro Ala Lys Arg 
465                 470                 475                 480 


Leu Lys Met Gly Ile Ala Val Pro Glu Ser Phe Met Asn Glu Val Ser 
                485                 490                 495     


Val Asn Asn Leu Gly Val Asp Phe Glu Asn His Thr His His Ile Thr 
            500                 505                 510         


Ser Ala Lys Met Ala Val Ser Val Ala Asp Phe Gly Ser Leu Ser Ala 
        515                 520                 525             


Asn Glu Thr Asn Gly Phe Ile Ser Ala His Ala Leu His Gln His Ala 
    530                 535                 540                 


Ala Leu His Ser Glu 
545                 


<210>  35
<211>  7398
<212>  DNA
<213>  Homo sapiens

<400>  35
atgaacacag aagagctgga gttattgagt gactccaaat acagaaacta tgtagcagca       60

attgacaaag cactaaagaa ttttgaatac tccagtgaat gggcagattt gatatcagca      120

cttggaaaac ttaataaggt tttacaaaat aatgcaaagt accaagtagt acccaaaaag      180

ctgaccatag gcaaacgcct agctcaatgt ctacatccag cattaccagg tggagttcat      240

cggaaggcgc ttgaaacata tgaaattatc ttcaaaataa ttggacctaa gcgacttgcc      300

aaagatcttt ttttatatag ttctggatta tttcctcttc ttgcaaatgc tgccatgtct      360

gtgaaaccaa cattgctcag tttgtatgag atatattatc tgcctttggg taaaacactg      420

aaacctggtc tacagggatt gcttactggt attcttcctg gcttagaaga aggatcagag      480

tactatgaga gaacaaatat gttgttggaa aaggttgctg ctgctgtgga ccagtcagca      540

ttctacagtg ccctgtgggg tagtcttctc accagtcctg ctgtgcgttt acctggaatc      600

acgtatgttc ttgcccattt aaacaggaag ctttctatgg aagatcaact ttatataatt      660

ggcagtgata ttgagctaat ggtagaagca gtaagtactt cagtgcagga ctcaagtgta      720

cttgtacaga gaagcacact ggacctcata ctcttctgtt ttccattcca catgagtcag      780

gccactcgac cggatatgat caggatcttg tcagcagccc ttcatgtagt gctaaggagg      840

gatatgtctc tgaatcgaag actttatgca tggcttcttg gttttgataa caacggtgct      900

atcataggac ccagaagcac aagacacagt aatcctgaag aacatgccac ttactatttc      960

actacctttt caaaagaatt attagtccag gcaatggtgg gaatcttaca agtgaatgga     1020

tttggagaag agaacactct aatgcaggat ctaaagcctt ttcgcatttt aatcagttta     1080

ctggacaaac ctgagctagg acctgtaatt ctagaagatg tcctgattga agtgtttaga     1140

acattatatt ctcaatgcaa agcagagttg gatcttcaaa ctgaaccacc cttcagcaag     1200

gatcatgctc agttaagcag taaattaaga gaaaataaga aaacagcaga gctgattaaa     1260

actgctaacc ttctctttaa ttccttcgaa ccttattata tgtgggatta tgttgcacgc     1320

tggtttgaag aatgttgtag gaggacactg catgtgagac ttcagattgg acctggagat     1380

agtaatgact catctgaatt acagctgacc aatttctgct tactggtgga ttttttgttg     1440

gacatagttt ctttgcctac tagaagtatg agggtgctgt gtcaggagac ttacattgaa     1500

atccagacag aacacttgcc ccagttgctg ctcagaatga tttctgcctt gacaagccat     1560

ctccagacat tgcacttatc tgaactcaca gattctctca gactctgctc aaagatcctt     1620

agcaaggttc agcctccact gttatctgct agcactggag gtgttttgca gtttccaagt     1680

gggcagaaca attcagtcaa agagtgggaa gacaaaaagg tatcatcagt ttctcatgaa     1740

aatcctactg aagtgtttga agatggagaa aatccaccaa gtagtcgatc atcagagagt     1800

ggattcactg agtttataca atatcaagca gaccgaactg atgatattga cagagaactg     1860

agtgagggcc agggggcagc tgccatccca attggtagca catcctctga gacagaaaca     1920

gcatccactg tgggatctga agaaaccatc atccagaccc cttccgtagt cactcagggg     1980

acagcaaccc gaagtaggaa gacagcccaa aagactgcaa tgcagtgctg cttggagtat     2040

gtccaacagt ttcttaccag acttatcaac ctctacatca ttcagaataa ctctttttct     2100

cagtctttgg ctacagaaca tcaaggggat cttggtcgag aacaaggaga gacttcaaaa     2160

tgggacagaa attcacaagg agatgtaaaa gagaaaaaca taagtaaaca aaaaacttct     2220

aaagaatacc tgtctgcctt ccttgctgcc tgtcagctct tcctagagtg ctcaagtttc     2280

ccagtttaca ttgctgaggg gaaccataca tcagagttac gttctgaaaa attggagact     2340

gactgtgagc atgtgcagcc tccacagtgg ctccagactc tgatgaatgc ttgcagccaa     2400

gcaagtgatt tcagtgttca gagtgttgct atttcactag ttatggacct ggtgggactg     2460

acacagtctg tggccatggt cactggggaa aacatcaaca gtgtagagcc tgcacaaccc     2520

ttaagtccaa accagggaag agtagctgtg gttattagac ctcccctcac tcagggcaat     2580

ctgaggtaca tagctgagaa gactgaattt ttcaagcatg tagctttaac attgtgggac     2640

cagttgggag atgggacacc tcagcatcac cagaagagtg tggaactatt ttatcaatta     2700

cataacttag ttccttcttc tagcatctgt gaggatgtta taagtcagca gttaacccat     2760

aaagataaga aaataaggat ggaagcacat gccaagtttg cagttctttg gcatctaacg     2820

agagatctcc atataaataa atcttcatct tttgtacgtt cttttgacag gtcactgttc     2880

atcatgttag atagccttaa cagtctcgat ggttctacta gctctgtggg acaagcctgg     2940

ctgaaccaag tcctacaaag acatgatatt gcacgagttt tggaaccatt gctattgctc     3000

ctgcttcatc caaaaactca gagggtttca gtacagcgtg tacaagcaga acgttattgg     3060

aataagtctc cctgttatcc aggagaggag agtgacaagc atttcatgca aaattttgcc     3120

tgcagcaatg tgagccaagt acaactcatc acatcaaaag gaaatggtga aaagccactt     3180

accatggatg aaatagagaa ctttagtctc actgtgaatc cattaagtga cagactttcc     3240

ctcctaagta ccagcagtga gacaattcca atggttgtgt ctgattttga tcttccagac     3300

caacagatag aaatacttca gagttctgac tcgggatgtt cacagtcctc tgctggggac     3360

aacttgagtt acgaagttga tcctgaaacc gtgaatgccc aagaggattc tcaaatgccc     3420

aaggaaagct ccccagatga tgatgttcaa caggtagtat ttgacctgat atgtaaagtt     3480

gtaagtggcc tcgaagtgga atctgcatca gttacatctc aattagaaat tgaagctatg     3540

cccccaaagt gcagtgatat agatccagat gaagagacga ttaaaattga agatgactcc     3600

attcaacaga gtcagaatgc tttgctgagt aatgaaagtt ctcagtttct gtctgtgtct     3660

gcagagggag gccatgagtg tgtggcaaat ggaatctcca ggaatagctc ctcaccttgt     3720

atttcaggaa ccacacacac tcttcatgac tcttctgttg cttccataga aaccaaatct     3780

agacaaagga gtcacagtag tattcaattc agcttcaaag aaaaattatc agaaaaagtt     3840

tcggagaagg aaacaatagt taaggagtca ggtaaacaac caggagcaaa acctaaagta     3900

aaacttgcca gaaaaaagga tgatgacaag aaaaaatctt caaatgaaaa actcaaacaa     3960

accagtgtat tcttcagtga tggtctggat ttagagaact ggtatagctg tggagaggga     4020

gacatttctg aaattgagag tgacatgggt tctccaggat ctcgaaaatc tcccaatttc     4080

aacattcatc ctctctatca acatgtgctc ctgtatctcc agttgtatga ttcatccagg     4140

actttgtatg ctttctctgc catcaaagcc atcttgaaaa ctaaccctat agcttttgta     4200

aatgccattt caactactag tgtaaataat gcatatactc ctcagttgtc tctccttcag     4260

aatctattgg ccagacaccg gatttctgtt atgggcaaag atttttatag tcacattcca     4320

gtggactcaa atcataactt ccggagttct atgtacatag aaattcttat ttctctctgc     4380

ttatattaca tgcgtagcca ttacccaact catgtcaagg ttactgcaca agatttaata     4440

ggcaatcgaa acatgcaaat gatgagcata gaaattctga cactactctt cactgagctg     4500

gcaaaagtaa tagaaagctc agcgaagggt ttccctagtt ttatttctga tatgttatct     4560

aagtgcaaag ttcagaaagt gattcttcat tgtttgctgt catctatctt tagtgctcag     4620

aaatggcata gtgaaaaaat ggcaggtaag aacctggttg ctgtggaaga aggtttctca     4680

gaggacagcc ttattaattt ctcagaggat gaatttgaca atggcagcac gttgcagtca     4740

caacttctta aggtgcttca gaggctgatt gttctagaac acagagtaat gactattcct     4800

gaagagaatg aaacaggttt tgattttgtt gtatctgact tagaacacat cagtccccat     4860

caacccatga cttctcttca gtatttgcat gctcagccaa tcacatgtca aggcatgttc     4920

ctctgtgcag tgatacgagc tttgcatcag cactgtgcat gtaagatgca cccacaatgg     4980

attggtttaa tcacatctac tctgccttac atgggaaaag ttctgcagag agtggttgtt     5040

tctgtgacac tacaactgtg cagaaattta gataatctaa ttcagcagta caaatacgaa     5100

acaggattat ctgatagtag gcctctgtgg atggcatcaa ttattccacc agatatgatt     5160

cttactcttt tggaagggat tacagccatt atccattact gtttgttgga tccaactaca     5220

cagtatcacc aacttttggt cagtgtagac cagaaacact tgtttgaagc acgcagtgga     5280

atcctctcaa tccttcatat gatcatgtcc tctgtgacac tgctttggag catactgcat     5340

caagctgatt cttcagaaaa gatgactatt gccgcatccg catctcttac cactattaat     5400

cttggagcta caaagaactt gagacaacag attcttgaat tgttgggccc catttcaatg     5460

aatcatggtg ttcactttat ggctgccatt gcatttgtgt ggaatgaaag aagacagaat     5520

aaaacaacca ccaggaccaa ggtcattcct gcagccagtg aagaacagct tttattagtg     5580

gaattggttc gttcaatcag tgtcatgaga gcagaaactg ttatccagac tgtaaaagaa     5640

gttttaaagc agccaccagc catagccaag gacaagaaac atctttcttt ggaagtctgc     5700

atgcttcagt ttttctatgc ttatattcaa agaattccag tgcccaattt agtggatagc     5760

tgggcgtcac tgttgatact tctgaaagac tctatacaac tgagtcttcc agctccaggg     5820

cagtttctta tacttggggt tctgaatgag tttattatga aaaaccctag tttggaaaat     5880

aaaaaagacc aaagagacct tcaggatgta actcacaaaa tagtggatgc aattggtgca     5940

attgctggtt cttctctgga acagacaaca tggctgcgac gaaatcttga agttaagcct     6000

tctcccaaaa taatggtaga tggaaccaat ttggaatctg atgttgaaga tatgttatca     6060

cctgcaatgg aaaccgcaaa cataactcct tctgtatata gtgtccatgc attgacatta     6120

ctctctgagg ttttggctca tcttttggat atggttttct atagtgatga aaaggagcgg     6180

gttattcctt tacttgtaaa tattatgcat tatgttgtgc cctacctcag aaatcacagt     6240

gcacataatg cccctagtta tcgagcttgt gtccagctgc tcagcagtct tagtgggtat     6300

cagtacacac ggagagcttg gaaaaaagaa gcttttgacc tctttatgga tcccagtttc     6360

tttcagatgg atgcctcttg tgttaatcat tggagagcaa ttatggacaa tctgatgaca     6420

catgataaaa caacatttag agatttgatg actcgtgtag cagtggctca aagcagttca     6480

cttaatctct ttgcaaaccg tgatgtggag ctagaacaga gagctatgct tcttaaaaga     6540

ttagcatttg ctatttttag cagtgaaatt gaccagtacc agaaatatct tccagatata     6600

caagagagat tggttgagag tctccgtttg ccacaggtgc caactctcca ttctcaagtg     6660

ttcctgtttt tcagagtgtt acttttaaga atgtctcccc aacatcttac ctcactctgg     6720

cctaccatga ttacagaact tgtacaagta tttttactga tggagcagga actcactgct     6780

gatgaagata tttcacggac ttcagggccc tctgtggctg gtctggagac aacgtacaca     6840

ggaggtaatg gcttctctac ttcatataac agccagcggt ggttaaacct ctatctctct     6900

gcttgcaaat ttttggattt ggctctcgca ttgccctctg aaaaccttcc tcagtttcag     6960

atgtaccgat gggcctttat tccagaagcc tcagatgatt caggtttgga agtcagaagg     7020

cagggtatac atcaacgaga atttaaacct tacgtggtac gactagcaaa acttcttcgg     7080

aaaagagcaa agaaaaatcc agaggaagac aactcaggga gaacattggg ttgggagcca     7140

gggcacttgc tgctcaccat ctgcaccgtg cgcagtatgg agcagctcct gccgttcttc     7200

aatgtgctca gtcaagtctt caacagcaaa gtcacaagcc gatgtggagg acactcaggg     7260

agtcctatcc tctactcaaa tgccttccct aataaggaca tgaaactgga gaaccacaaa     7320

ccatgttcca gcaaagccag gcaaaaaata gaagagatgg tagaaaaaga ttttctggaa     7380

gggatgataa aaacttga                                                   7398


<210>  36
<211>  2465
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asn Thr Glu Glu Leu Glu Leu Leu Ser Asp Ser Lys Tyr Arg Asn 
1               5                   10                  15      


Tyr Val Ala Ala Ile Asp Lys Ala Leu Lys Asn Phe Glu Tyr Ser Ser 
            20                  25                  30          


Glu Trp Ala Asp Leu Ile Ser Ala Leu Gly Lys Leu Asn Lys Val Leu 
        35                  40                  45              


Gln Asn Asn Ala Lys Tyr Gln Val Val Pro Lys Lys Leu Thr Ile Gly 
    50                  55                  60                  


Lys Arg Leu Ala Gln Cys Leu His Pro Ala Leu Pro Gly Gly Val His 
65                  70                  75                  80  


Arg Lys Ala Leu Glu Thr Tyr Glu Ile Ile Phe Lys Ile Ile Gly Pro 
                85                  90                  95      


Lys Arg Leu Ala Lys Asp Leu Phe Leu Tyr Ser Ser Gly Leu Phe Pro 
            100                 105                 110         


Leu Leu Ala Asn Ala Ala Met Ser Val Lys Pro Thr Leu Leu Ser Leu 
        115                 120                 125             


Tyr Glu Ile Tyr Tyr Leu Pro Leu Gly Lys Thr Leu Lys Pro Gly Leu 
    130                 135                 140                 


Gln Gly Leu Leu Thr Gly Ile Leu Pro Gly Leu Glu Glu Gly Ser Glu 
145                 150                 155                 160 


Tyr Tyr Glu Arg Thr Asn Met Leu Leu Glu Lys Val Ala Ala Ala Val 
                165                 170                 175     


Asp Gln Ser Ala Phe Tyr Ser Ala Leu Trp Gly Ser Leu Leu Thr Ser 
            180                 185                 190         


Pro Ala Val Arg Leu Pro Gly Ile Thr Tyr Val Leu Ala His Leu Asn 
        195                 200                 205             


Arg Lys Leu Ser Met Glu Asp Gln Leu Tyr Ile Ile Gly Ser Asp Ile 
    210                 215                 220                 


Glu Leu Met Val Glu Ala Val Ser Thr Ser Val Gln Asp Ser Ser Val 
225                 230                 235                 240 


Leu Val Gln Arg Ser Thr Leu Asp Leu Ile Leu Phe Cys Phe Pro Phe 
                245                 250                 255     


His Met Ser Gln Ala Thr Arg Pro Asp Met Ile Arg Ile Leu Ser Ala 
            260                 265                 270         


Ala Leu His Val Val Leu Arg Arg Asp Met Ser Leu Asn Arg Arg Leu 
        275                 280                 285             


Tyr Ala Trp Leu Leu Gly Phe Asp Asn Asn Gly Ala Ile Ile Gly Pro 
    290                 295                 300                 


Arg Ser Thr Arg His Ser Asn Pro Glu Glu His Ala Thr Tyr Tyr Phe 
305                 310                 315                 320 


Thr Thr Phe Ser Lys Glu Leu Leu Val Gln Ala Met Val Gly Ile Leu 
                325                 330                 335     


Gln Val Asn Gly Phe Gly Glu Glu Asn Thr Leu Met Gln Asp Leu Lys 
            340                 345                 350         


Pro Phe Arg Ile Leu Ile Ser Leu Leu Asp Lys Pro Glu Leu Gly Pro 
        355                 360                 365             


Val Ile Leu Glu Asp Val Leu Ile Glu Val Phe Arg Thr Leu Tyr Ser 
    370                 375                 380                 


Gln Cys Lys Ala Glu Leu Asp Leu Gln Thr Glu Pro Pro Phe Ser Lys 
385                 390                 395                 400 


Asp His Ala Gln Leu Ser Ser Lys Leu Arg Glu Asn Lys Lys Thr Ala 
                405                 410                 415     


Glu Leu Ile Lys Thr Ala Asn Leu Leu Phe Asn Ser Phe Glu Pro Tyr 
            420                 425                 430         


Tyr Met Trp Asp Tyr Val Ala Arg Trp Phe Glu Glu Cys Cys Arg Arg 
        435                 440                 445             


Thr Leu His Val Arg Leu Gln Ile Gly Pro Gly Asp Ser Asn Asp Ser 
    450                 455                 460                 


Ser Glu Leu Gln Leu Thr Asn Phe Cys Leu Leu Val Asp Phe Leu Leu 
465                 470                 475                 480 


Asp Ile Val Ser Leu Pro Thr Arg Ser Met Arg Val Leu Cys Gln Glu 
                485                 490                 495     


Thr Tyr Ile Glu Ile Gln Thr Glu His Leu Pro Gln Leu Leu Leu Arg 
            500                 505                 510         


Met Ile Ser Ala Leu Thr Ser His Leu Gln Thr Leu His Leu Ser Glu 
        515                 520                 525             


Leu Thr Asp Ser Leu Arg Leu Cys Ser Lys Ile Leu Ser Lys Val Gln 
    530                 535                 540                 


Pro Pro Leu Leu Ser Ala Ser Thr Gly Gly Val Leu Gln Phe Pro Ser 
545                 550                 555                 560 


Gly Gln Asn Asn Ser Val Lys Glu Trp Glu Asp Lys Lys Val Ser Ser 
                565                 570                 575     


Val Ser His Glu Asn Pro Thr Glu Val Phe Glu Asp Gly Glu Asn Pro 
            580                 585                 590         


Pro Ser Ser Arg Ser Ser Glu Ser Gly Phe Thr Glu Phe Ile Gln Tyr 
        595                 600                 605             


Gln Ala Asp Arg Thr Asp Asp Ile Asp Arg Glu Leu Ser Glu Gly Gln 
    610                 615                 620                 


Gly Ala Ala Ala Ile Pro Ile Gly Ser Thr Ser Ser Glu Thr Glu Thr 
625                 630                 635                 640 


Ala Ser Thr Val Gly Ser Glu Glu Thr Ile Ile Gln Thr Pro Ser Val 
                645                 650                 655     


Val Thr Gln Gly Thr Ala Thr Arg Ser Arg Lys Thr Ala Gln Lys Thr 
            660                 665                 670         


Ala Met Gln Cys Cys Leu Glu Tyr Val Gln Gln Phe Leu Thr Arg Leu 
        675                 680                 685             


Ile Asn Leu Tyr Ile Ile Gln Asn Asn Ser Phe Ser Gln Ser Leu Ala 
    690                 695                 700                 


Thr Glu His Gln Gly Asp Leu Gly Arg Glu Gln Gly Glu Thr Ser Lys 
705                 710                 715                 720 


Trp Asp Arg Asn Ser Gln Gly Asp Val Lys Glu Lys Asn Ile Ser Lys 
                725                 730                 735     


Gln Lys Thr Ser Lys Glu Tyr Leu Ser Ala Phe Leu Ala Ala Cys Gln 
            740                 745                 750         


Leu Phe Leu Glu Cys Ser Ser Phe Pro Val Tyr Ile Ala Glu Gly Asn 
        755                 760                 765             


His Thr Ser Glu Leu Arg Ser Glu Lys Leu Glu Thr Asp Cys Glu His 
    770                 775                 780                 


Val Gln Pro Pro Gln Trp Leu Gln Thr Leu Met Asn Ala Cys Ser Gln 
785                 790                 795                 800 


Ala Ser Asp Phe Ser Val Gln Ser Val Ala Ile Ser Leu Val Met Asp 
                805                 810                 815     


Leu Val Gly Leu Thr Gln Ser Val Ala Met Val Thr Gly Glu Asn Ile 
            820                 825                 830         


Asn Ser Val Glu Pro Ala Gln Pro Leu Ser Pro Asn Gln Gly Arg Val 
        835                 840                 845             


Ala Val Val Ile Arg Pro Pro Leu Thr Gln Gly Asn Leu Arg Tyr Ile 
    850                 855                 860                 


Ala Glu Lys Thr Glu Phe Phe Lys His Val Ala Leu Thr Leu Trp Asp 
865                 870                 875                 880 


Gln Leu Gly Asp Gly Thr Pro Gln His His Gln Lys Ser Val Glu Leu 
                885                 890                 895     


Phe Tyr Gln Leu His Asn Leu Val Pro Ser Ser Ser Ile Cys Glu Asp 
            900                 905                 910         


Val Ile Ser Gln Gln Leu Thr His Lys Asp Lys Lys Ile Arg Met Glu 
        915                 920                 925             


Ala His Ala Lys Phe Ala Val Leu Trp His Leu Thr Arg Asp Leu His 
    930                 935                 940                 


Ile Asn Lys Ser Ser Ser Phe Val Arg Ser Phe Asp Arg Ser Leu Phe 
945                 950                 955                 960 


Ile Met Leu Asp Ser Leu Asn Ser Leu Asp Gly Ser Thr Ser Ser Val 
                965                 970                 975     


Gly Gln Ala Trp Leu Asn Gln Val Leu Gln Arg His Asp Ile Ala Arg 
            980                 985                 990         


Val Leu Glu Pro Leu Leu Leu Leu  Leu Leu His Pro Lys  Thr Gln Arg 
        995                 1000                 1005             


Val Ser  Val Gln Arg Val Gln  Ala Glu Arg Tyr Trp  Asn Lys Ser 
    1010                 1015                 1020             


Pro Cys  Tyr Pro Gly Glu Glu  Ser Asp Lys His Phe  Met Gln Asn 
    1025                 1030                 1035             


Phe Ala  Cys Ser Asn Val Ser  Gln Val Gln Leu Ile  Thr Ser Lys 
    1040                 1045                 1050             


Gly Asn  Gly Glu Lys Pro Leu  Thr Met Asp Glu Ile  Glu Asn Phe 
    1055                 1060                 1065             


Ser Leu  Thr Val Asn Pro Leu  Ser Asp Arg Leu Ser  Leu Leu Ser 
    1070                 1075                 1080             


Thr Ser  Ser Glu Thr Ile Pro  Met Val Val Ser Asp  Phe Asp Leu 
    1085                 1090                 1095             


Pro Asp  Gln Gln Ile Glu Ile  Leu Gln Ser Ser Asp  Ser Gly Cys 
    1100                 1105                 1110             


Ser Gln  Ser Ser Ala Gly Asp  Asn Leu Ser Tyr Glu  Val Asp Pro 
    1115                 1120                 1125             


Glu Thr  Val Asn Ala Gln Glu  Asp Ser Gln Met Pro  Lys Glu Ser 
    1130                 1135                 1140             


Ser Pro  Asp Asp Asp Val Gln  Gln Val Val Phe Asp  Leu Ile Cys 
    1145                 1150                 1155             


Lys Val  Val Ser Gly Leu Glu  Val Glu Ser Ala Ser  Val Thr Ser 
    1160                 1165                 1170             


Gln Leu  Glu Ile Glu Ala Met  Pro Pro Lys Cys Ser  Asp Ile Asp 
    1175                 1180                 1185             


Pro Asp  Glu Glu Thr Ile Lys  Ile Glu Asp Asp Ser  Ile Gln Gln 
    1190                 1195                 1200             


Ser Gln  Asn Ala Leu Leu Ser  Asn Glu Ser Ser Gln  Phe Leu Ser 
    1205                 1210                 1215             


Val Ser  Ala Glu Gly Gly His  Glu Cys Val Ala Asn  Gly Ile Ser 
    1220                 1225                 1230             


Arg Asn  Ser Ser Ser Pro Cys  Ile Ser Gly Thr Thr  His Thr Leu 
    1235                 1240                 1245             


His Asp  Ser Ser Val Ala Ser  Ile Glu Thr Lys Ser  Arg Gln Arg 
    1250                 1255                 1260             


Ser His  Ser Ser Ile Gln Phe  Ser Phe Lys Glu Lys  Leu Ser Glu 
    1265                 1270                 1275             


Lys Val  Ser Glu Lys Glu Thr  Ile Val Lys Glu Ser  Gly Lys Gln 
    1280                 1285                 1290             


Pro Gly  Ala Lys Pro Lys Val  Lys Leu Ala Arg Lys  Lys Asp Asp 
    1295                 1300                 1305             


Asp Lys  Lys Lys Ser Ser Asn  Glu Lys Leu Lys Gln  Thr Ser Val 
    1310                 1315                 1320             


Phe Phe  Ser Asp Gly Leu Asp  Leu Glu Asn Trp Tyr  Ser Cys Gly 
    1325                 1330                 1335             


Glu Gly  Asp Ile Ser Glu Ile  Glu Ser Asp Met Gly  Ser Pro Gly 
    1340                 1345                 1350             


Ser Arg  Lys Ser Pro Asn Phe  Asn Ile His Pro Leu  Tyr Gln His 
    1355                 1360                 1365             


Val Leu  Leu Tyr Leu Gln Leu  Tyr Asp Ser Ser Arg  Thr Leu Tyr 
    1370                 1375                 1380             


Ala Phe  Ser Ala Ile Lys Ala  Ile Leu Lys Thr Asn  Pro Ile Ala 
    1385                 1390                 1395             


Phe Val  Asn Ala Ile Ser Thr  Thr Ser Val Asn Asn  Ala Tyr Thr 
    1400                 1405                 1410             


Pro Gln  Leu Ser Leu Leu Gln  Asn Leu Leu Ala Arg  His Arg Ile 
    1415                 1420                 1425             


Ser Val  Met Gly Lys Asp Phe  Tyr Ser His Ile Pro  Val Asp Ser 
    1430                 1435                 1440             


Asn His  Asn Phe Arg Ser Ser  Met Tyr Ile Glu Ile  Leu Ile Ser 
    1445                 1450                 1455             


Leu Cys  Leu Tyr Tyr Met Arg  Ser His Tyr Pro Thr  His Val Lys 
    1460                 1465                 1470             


Val Thr  Ala Gln Asp Leu Ile  Gly Asn Arg Asn Met  Gln Met Met 
    1475                 1480                 1485             


Ser Ile  Glu Ile Leu Thr Leu  Leu Phe Thr Glu Leu  Ala Lys Val 
    1490                 1495                 1500             


Ile Glu  Ser Ser Ala Lys Gly  Phe Pro Ser Phe Ile  Ser Asp Met 
    1505                 1510                 1515             


Leu Ser  Lys Cys Lys Val Gln  Lys Val Ile Leu His  Cys Leu Leu 
    1520                 1525                 1530             


Ser Ser  Ile Phe Ser Ala Gln  Lys Trp His Ser Glu  Lys Met Ala 
    1535                 1540                 1545             


Gly Lys  Asn Leu Val Ala Val  Glu Glu Gly Phe Ser  Glu Asp Ser 
    1550                 1555                 1560             


Leu Ile  Asn Phe Ser Glu Asp  Glu Phe Asp Asn Gly  Ser Thr Leu 
    1565                 1570                 1575             


Gln Ser  Gln Leu Leu Lys Val  Leu Gln Arg Leu Ile  Val Leu Glu 
    1580                 1585                 1590             


His Arg  Val Met Thr Ile Pro  Glu Glu Asn Glu Thr  Gly Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Ser Asp Leu Glu  His Ile Ser Pro His  Gln Pro Met 
    1610                 1615                 1620             


Thr Ser  Leu Gln Tyr Leu His  Ala Gln Pro Ile Thr  Cys Gln Gly 
    1625                 1630                 1635             


Met Phe  Leu Cys Ala Val Ile  Arg Ala Leu His Gln  His Cys Ala 
    1640                 1645                 1650             


Cys Lys  Met His Pro Gln Trp  Ile Gly Leu Ile Thr  Ser Thr Leu 
    1655                 1660                 1665             


Pro Tyr  Met Gly Lys Val Leu  Gln Arg Val Val Val  Ser Val Thr 
    1670                 1675                 1680             


Leu Gln  Leu Cys Arg Asn Leu  Asp Asn Leu Ile Gln  Gln Tyr Lys 
    1685                 1690                 1695             


Tyr Glu  Thr Gly Leu Ser Asp  Ser Arg Pro Leu Trp  Met Ala Ser 
    1700                 1705                 1710             


Ile Ile  Pro Pro Asp Met Ile  Leu Thr Leu Leu Glu  Gly Ile Thr 
    1715                 1720                 1725             


Ala Ile  Ile His Tyr Cys Leu  Leu Asp Pro Thr Thr  Gln Tyr His 
    1730                 1735                 1740             


Gln Leu  Leu Val Ser Val Asp  Gln Lys His Leu Phe  Glu Ala Arg 
    1745                 1750                 1755             


Ser Gly  Ile Leu Ser Ile Leu  His Met Ile Met Ser  Ser Val Thr 
    1760                 1765                 1770             


Leu Leu  Trp Ser Ile Leu His  Gln Ala Asp Ser Ser  Glu Lys Met 
    1775                 1780                 1785             


Thr Ile  Ala Ala Ser Ala Ser  Leu Thr Thr Ile Asn  Leu Gly Ala 
    1790                 1795                 1800             


Thr Lys  Asn Leu Arg Gln Gln  Ile Leu Glu Leu Leu  Gly Pro Ile 
    1805                 1810                 1815             


Ser Met  Asn His Gly Val His  Phe Met Ala Ala Ile  Ala Phe Val 
    1820                 1825                 1830             


Trp Asn  Glu Arg Arg Gln Asn  Lys Thr Thr Thr Arg  Thr Lys Val 
    1835                 1840                 1845             


Ile Pro  Ala Ala Ser Glu Glu  Gln Leu Leu Leu Val  Glu Leu Val 
    1850                 1855                 1860             


Arg Ser  Ile Ser Val Met Arg  Ala Glu Thr Val Ile  Gln Thr Val 
    1865                 1870                 1875             


Lys Glu  Val Leu Lys Gln Pro  Pro Ala Ile Ala Lys  Asp Lys Lys 
    1880                 1885                 1890             


His Leu  Ser Leu Glu Val Cys  Met Leu Gln Phe Phe  Tyr Ala Tyr 
    1895                 1900                 1905             


Ile Gln  Arg Ile Pro Val Pro  Asn Leu Val Asp Ser  Trp Ala Ser 
    1910                 1915                 1920             


Leu Leu  Ile Leu Leu Lys Asp  Ser Ile Gln Leu Ser  Leu Pro Ala 
    1925                 1930                 1935             


Pro Gly  Gln Phe Leu Ile Leu  Gly Val Leu Asn Glu  Phe Ile Met 
    1940                 1945                 1950             


Lys Asn  Pro Ser Leu Glu Asn  Lys Lys Asp Gln Arg  Asp Leu Gln 
    1955                 1960                 1965             


Asp Val  Thr His Lys Ile Val  Asp Ala Ile Gly Ala  Ile Ala Gly 
    1970                 1975                 1980             


Ser Ser  Leu Glu Gln Thr Thr  Trp Leu Arg Arg Asn  Leu Glu Val 
    1985                 1990                 1995             


Lys Pro  Ser Pro Lys Ile Met  Val Asp Gly Thr Asn  Leu Glu Ser 
    2000                 2005                 2010             


Asp Val  Glu Asp Met Leu Ser  Pro Ala Met Glu Thr  Ala Asn Ile 
    2015                 2020                 2025             


Thr Pro  Ser Val Tyr Ser Val  His Ala Leu Thr Leu  Leu Ser Glu 
    2030                 2035                 2040             


Val Leu  Ala His Leu Leu Asp  Met Val Phe Tyr Ser  Asp Glu Lys 
    2045                 2050                 2055             


Glu Arg  Val Ile Pro Leu Leu  Val Asn Ile Met His  Tyr Val Val 
    2060                 2065                 2070             


Pro Tyr  Leu Arg Asn His Ser  Ala His Asn Ala Pro  Ser Tyr Arg 
    2075                 2080                 2085             


Ala Cys  Val Gln Leu Leu Ser  Ser Leu Ser Gly Tyr  Gln Tyr Thr 
    2090                 2095                 2100             


Arg Arg  Ala Trp Lys Lys Glu  Ala Phe Asp Leu Phe  Met Asp Pro 
    2105                 2110                 2115             


Ser Phe  Phe Gln Met Asp Ala  Ser Cys Val Asn His  Trp Arg Ala 
    2120                 2125                 2130             


Ile Met  Asp Asn Leu Met Thr  His Asp Lys Thr Thr  Phe Arg Asp 
    2135                 2140                 2145             


Leu Met  Thr Arg Val Ala Val  Ala Gln Ser Ser Ser  Leu Asn Leu 
    2150                 2155                 2160             


Phe Ala  Asn Arg Asp Val Glu  Leu Glu Gln Arg Ala  Met Leu Leu 
    2165                 2170                 2175             


Lys Arg  Leu Ala Phe Ala Ile  Phe Ser Ser Glu Ile  Asp Gln Tyr 
    2180                 2185                 2190             


Gln Lys  Tyr Leu Pro Asp Ile  Gln Glu Arg Leu Val  Glu Ser Leu 
    2195                 2200                 2205             


Arg Leu  Pro Gln Val Pro Thr  Leu His Ser Gln Val  Phe Leu Phe 
    2210                 2215                 2220             


Phe Arg  Val Leu Leu Leu Arg  Met Ser Pro Gln His  Leu Thr Ser 
    2225                 2230                 2235             


Leu Trp  Pro Thr Met Ile Thr  Glu Leu Val Gln Val  Phe Leu Leu 
    2240                 2245                 2250             


Met Glu  Gln Glu Leu Thr Ala  Asp Glu Asp Ile Ser  Arg Thr Ser 
    2255                 2260                 2265             


Gly Pro  Ser Val Ala Gly Leu  Glu Thr Thr Tyr Thr  Gly Gly Asn 
    2270                 2275                 2280             


Gly Phe  Ser Thr Ser Tyr Asn  Ser Gln Arg Trp Leu  Asn Leu Tyr 
    2285                 2290                 2295             


Leu Ser  Ala Cys Lys Phe Leu  Asp Leu Ala Leu Ala  Leu Pro Ser 
    2300                 2305                 2310             


Glu Asn  Leu Pro Gln Phe Gln  Met Tyr Arg Trp Ala  Phe Ile Pro 
    2315                 2320                 2325             


Glu Ala  Ser Asp Asp Ser Gly  Leu Glu Val Arg Arg  Gln Gly Ile 
    2330                 2335                 2340             


His Gln  Arg Glu Phe Lys Pro  Tyr Val Val Arg Leu  Ala Lys Leu 
    2345                 2350                 2355             


Leu Arg  Lys Arg Ala Lys Lys  Asn Pro Glu Glu Asp  Asn Ser Gly 
    2360                 2365                 2370             


Arg Thr  Leu Gly Trp Glu Pro  Gly His Leu Leu Leu  Thr Ile Cys 
    2375                 2380                 2385             


Thr Val  Arg Ser Met Glu Gln  Leu Leu Pro Phe Phe  Asn Val Leu 
    2390                 2395                 2400             


Ser Gln  Val Phe Asn Ser Lys  Val Thr Ser Arg Cys  Gly Gly His 
    2405                 2410                 2415             


Ser Gly  Ser Pro Ile Leu Tyr  Ser Asn Ala Phe Pro  Asn Lys Asp 
    2420                 2425                 2430             


Met Lys  Leu Glu Asn His Lys  Pro Cys Ser Ser Lys  Ala Arg Gln 
    2435                 2440                 2445             


Lys Ile  Glu Glu Met Val Glu  Lys Asp Phe Leu Glu  Gly Met Ile 
    2450                 2455                 2460             


Lys Thr  
    2465 


<210>  37
<211>  1737
<212>  DNA
<213>  Homo sapiens

<400>  37
atggctgaag aatcaagaaa gccttcagcc ccatccccac cagaccagac tcctgaagag       60

gatcttgtaa tcgtcaaggt agaggaggat catggttggg accaggaatc tagtctgcat      120

gaaagtaacc ctcttggcca agaagtgttc cgcctgcgct tcaggcagtt acgctaccag      180

gagacactag gaccccgaga agctctgatc caactacggg ccctttgcca tcagtggctg      240

aggccagatt tgaacaccaa ggaacagatc ctggagctgc tggtgctgga gcagttcttg      300

accatcctac ctgaggagct ccagacactg gttaaggaac atcagctaga gaacggagag      360

gaggtggtga ccctattaga ggatttggaa aggcagattg atatactagg acgaccagtc      420

tcagctcgcg tacatggaca tagggtactc tgggaggagg tagtacattc agcatctgca      480

ccagagcctc caaatactca gctccaatct gaggcaaccc aacataaatc tccagtgccc      540

caagagtcac aagagagagc catgtctact tcccagagtc ctactcgttc ccagaaagga      600

agttctggag accaggaaat gacagctaca cttctcacag cagggttcca gactttggag      660

aagattgaag acatggctgt gtcccttatt cgagaggagt ggcttcttga tccatcacag      720

aaggatctgt gtagagataa caggccagaa aatttcagaa acatgttctc cctgggtggt      780

gagaccagga gtgagaacag ggaattagct tcaaaacagg taatatctac tggaatccag      840

ccacatggag agacagctgc caaatgcaac ggggatgtta tcaggggtct tgagcatgaa      900

gaagcccgag accttctggg cagattagag aggcagcggg gaaatcccac acaagagaga      960

cgacataaat gtgatgaatg tgggaaaagc tttgctcaga gctcaggcct tgttcgccac     1020

tggagaatcc acactgggga gaaaccctat cagtgtaatg tgtgtggtaa agccttcagt     1080

tacaggtcag cccttctttc acatcaggat atccacaaca aagtaaaacg ctatcactgt     1140

aaggagtgtg gcaaagcctt cagtcagaac acaggcctga ttctgcacca gagaatccac     1200

actggggaga agccatatca gtgcaatcag tgtgggaagg ctttcagtca gagtgcgggc     1260

cttattctgc accagagaat ccacagtgga gagagaccct atgaatgtaa tgagtgtggg     1320

aaagctttca gtcatagctc acacctcatt ggacatcaga gaatccacac tggggagaag     1380

ccctatgagt gtgatgagtg tgggaaaacc ttcaggcgga gctcacatct tattggtcat     1440

cagaggagcc acactgggga gaaaccctac aaatgcaatg agtgtgggag ggccttcagt     1500

cagaagtcag gccttattga acatcagaga atccacactg gagaaagacc ctataaatgt     1560

aaagaatgtg ggaaagcttt caatgggaac actggtctca ttcaacacct gagaattcac     1620

acaggggaga agccctacca atgtaatgag tgtgggaaag cctttattca gaggtcaagt     1680

ctcattcgac atcagagaat ccacagtggt gaaaaatctg aatccataag cgtttag        1737


<210>  38
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Glu Glu Ser Arg Lys Pro Ser Ala Pro Ser Pro Pro Asp Gln 
1               5                   10                  15      


Thr Pro Glu Glu Asp Leu Val Ile Val Lys Val Glu Glu Asp His Gly 
            20                  25                  30          


Trp Asp Gln Glu Ser Ser Leu His Glu Ser Asn Pro Leu Gly Gln Glu 
        35                  40                  45              


Val Phe Arg Leu Arg Phe Arg Gln Leu Arg Tyr Gln Glu Thr Leu Gly 
    50                  55                  60                  


Pro Arg Glu Ala Leu Ile Gln Leu Arg Ala Leu Cys His Gln Trp Leu 
65                  70                  75                  80  


Arg Pro Asp Leu Asn Thr Lys Glu Gln Ile Leu Glu Leu Leu Val Leu 
                85                  90                  95      


Glu Gln Phe Leu Thr Ile Leu Pro Glu Glu Leu Gln Thr Leu Val Lys 
            100                 105                 110         


Glu His Gln Leu Glu Asn Gly Glu Glu Val Val Thr Leu Leu Glu Asp 
        115                 120                 125             


Leu Glu Arg Gln Ile Asp Ile Leu Gly Arg Pro Val Ser Ala Arg Val 
    130                 135                 140                 


His Gly His Arg Val Leu Trp Glu Glu Val Val His Ser Ala Ser Ala 
145                 150                 155                 160 


Pro Glu Pro Pro Asn Thr Gln Leu Gln Ser Glu Ala Thr Gln His Lys 
                165                 170                 175     


Ser Pro Val Pro Gln Glu Ser Gln Glu Arg Ala Met Ser Thr Ser Gln 
            180                 185                 190         


Ser Pro Thr Arg Ser Gln Lys Gly Ser Ser Gly Asp Gln Glu Met Thr 
        195                 200                 205             


Ala Thr Leu Leu Thr Ala Gly Phe Gln Thr Leu Glu Lys Ile Glu Asp 
    210                 215                 220                 


Met Ala Val Ser Leu Ile Arg Glu Glu Trp Leu Leu Asp Pro Ser Gln 
225                 230                 235                 240 


Lys Asp Leu Cys Arg Asp Asn Arg Pro Glu Asn Phe Arg Asn Met Phe 
                245                 250                 255     


Ser Leu Gly Gly Glu Thr Arg Ser Glu Asn Arg Glu Leu Ala Ser Lys 
            260                 265                 270         


Gln Val Ile Ser Thr Gly Ile Gln Pro His Gly Glu Thr Ala Ala Lys 
        275                 280                 285             


Cys Asn Gly Asp Val Ile Arg Gly Leu Glu His Glu Glu Ala Arg Asp 
    290                 295                 300                 


Leu Leu Gly Arg Leu Glu Arg Gln Arg Gly Asn Pro Thr Gln Glu Arg 
305                 310                 315                 320 


Arg His Lys Cys Asp Glu Cys Gly Lys Ser Phe Ala Gln Ser Ser Gly 
                325                 330                 335     


Leu Val Arg His Trp Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
            340                 345                 350         


Asn Val Cys Gly Lys Ala Phe Ser Tyr Arg Ser Ala Leu Leu Ser His 
        355                 360                 365             


Gln Asp Ile His Asn Lys Val Lys Arg Tyr His Cys Lys Glu Cys Gly 
    370                 375                 380                 


Lys Ala Phe Ser Gln Asn Thr Gly Leu Ile Leu His Gln Arg Ile His 
385                 390                 395                 400 


Thr Gly Glu Lys Pro Tyr Gln Cys Asn Gln Cys Gly Lys Ala Phe Ser 
                405                 410                 415     


Gln Ser Ala Gly Leu Ile Leu His Gln Arg Ile His Ser Gly Glu Arg 
            420                 425                 430         


Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser His Ser Ser His 
        435                 440                 445             


Leu Ile Gly His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
    450                 455                 460                 


Asp Glu Cys Gly Lys Thr Phe Arg Arg Ser Ser His Leu Ile Gly His 
465                 470                 475                 480 


Gln Arg Ser His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly 
                485                 490                 495     


Arg Ala Phe Ser Gln Lys Ser Gly Leu Ile Glu His Gln Arg Ile His 
            500                 505                 510         


Thr Gly Glu Arg Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Asn 
        515                 520                 525             


Gly Asn Thr Gly Leu Ile Gln His Leu Arg Ile His Thr Gly Glu Lys 
    530                 535                 540                 


Pro Tyr Gln Cys Asn Glu Cys Gly Lys Ala Phe Ile Gln Arg Ser Ser 
545                 550                 555                 560 


Leu Ile Arg His Gln Arg Ile His Ser Gly Glu Lys Ser Glu Ser Ile 
                565                 570                 575     


Ser Val 
        


<210>  39
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  39
atgcccacgg acatggaaca cacaggacat tacctacatc ttgcctttct gatgacaaca       60

gttttttctt tgtctcctgg aacaaaagca aactataccc gtctgtgggc taacagtact      120

tcttcctggg attcagttat tcaaaacaag acaggcagaa accaaaatga aaacattaac      180

acaaacccta taactcctga agtagattat aaaggtaatt ctacaaacat gcctgaaaca      240

tctcacatcg tagctttaac ttctaaatct gaacaggagc tttatatacc ttctgtcgtc      300

agcaacagtc cttcaacagt acagagcatt gaaaacacaa gcaaaagtca tggtgaaatt      360

ttcaaaaagg atgtctgtgc ggaaaacaac aacaacatgg ctatgctaat ttgcttaatt      420

ataattgcag tgctttttct tatctgtacc tttctatttc tatcaactgt ggttttggca      480

aacaaagtct cttctctcag acgatcaaaa caagtaggca agcgtcagcc tagaagcaat      540

ggcgattttc tggcaagcgg tctatggccc gctgaatcag acacttggaa aagaacaaaa      600

cagctcacag gacccaacct agtgatgcaa tctactggag tgctcacagc tacaagggaa      660

agaaaagatg aagaaggaac tgaaaaactt actaacaaac agataggtta g               711


<210>  40
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Thr Asp Met Glu His Thr Gly His Tyr Leu His Leu Ala Phe 
1               5                   10                  15      


Leu Met Thr Thr Val Phe Ser Leu Ser Pro Gly Thr Lys Ala Asn Tyr 
            20                  25                  30          


Thr Arg Leu Trp Ala Asn Ser Thr Ser Ser Trp Asp Ser Val Ile Gln 
        35                  40                  45              


Asn Lys Thr Gly Arg Asn Gln Asn Glu Asn Ile Asn Thr Asn Pro Ile 
    50                  55                  60                  


Thr Pro Glu Val Asp Tyr Lys Gly Asn Ser Thr Asn Met Pro Glu Thr 
65                  70                  75                  80  


Ser His Ile Val Ala Leu Thr Ser Lys Ser Glu Gln Glu Leu Tyr Ile 
                85                  90                  95      


Pro Ser Val Val Ser Asn Ser Pro Ser Thr Val Gln Ser Ile Glu Asn 
            100                 105                 110         


Thr Ser Lys Ser His Gly Glu Ile Phe Lys Lys Asp Val Cys Ala Glu 
        115                 120                 125             


Asn Asn Asn Asn Met Ala Met Leu Ile Cys Leu Ile Ile Ile Ala Val 
    130                 135                 140                 


Leu Phe Leu Ile Cys Thr Phe Leu Phe Leu Ser Thr Val Val Leu Ala 
145                 150                 155                 160 


Asn Lys Val Ser Ser Leu Arg Arg Ser Lys Gln Val Gly Lys Arg Gln 
                165                 170                 175     


Pro Arg Ser Asn Gly Asp Phe Leu Ala Ser Gly Leu Trp Pro Ala Glu 
            180                 185                 190         


Ser Asp Thr Trp Lys Arg Thr Lys Gln Leu Thr Gly Pro Asn Leu Val 
        195                 200                 205             


Met Gln Ser Thr Gly Val Leu Thr Ala Thr Arg Glu Arg Lys Asp Glu 
    210                 215                 220                 


Glu Gly Thr Glu Lys Leu Thr Asn Lys Gln Ile Gly 
225                 230                 235     


<210>  41
<211>  1887
<212>  DNA
<213>  Homo sapiens

<400>  41
atggattcgg gcagcagcag cagcgactcg gcgcccgatt gctgggacca ggtggacatg       60

gaatccccgg ggtcggcccc gagcggggat ggagtctcct ctgcggtggc cgaggcccag      120

cgcgagcccc tcagctcggc tttcagccgt aagctcaacg tcaacgccaa gcccttcgtg      180

cctaacgtac acgccgcgga gttcgtgccg tccttcctgc ggggcccgac tcagccgccc      240

accctcccgg ccggctccgg cagcaacgat gaaacctgca ccggcgcggg ataccctcaa      300

ggtaaaagga tgggacgggg ggcacctgtg gaaccttccc gagaggaacc gttagtgtcg      360

cttgaaggtt ccaattcagc cgttaccatg gaactttcag aacctgttgt agaaaatgga      420

gaggtggaaa tggccctaga agaatcatgg gagcacagta aagaagtaag tgaagccgag      480

cctgggggtg gttcctcggg agattcaggg cccccagaag aaagtggcca ggaaatgatg      540

gaggaaaaag aggaaataag aaaatccaaa tctgtgatcg taccctcagg tgcacctaag      600

aaagaacacg taaatgtagt attcattggc catgtagacg ctggcaagtc aaccatcgga      660

ggacagataa tgtttttgac tggaatggtt gacaaaagaa cactggagaa atatgaaaga      720

gaagctaagg aaaaaaacag agaaacctgg tatttgtcct gggccttaga tacaaatcag      780

gaggaacgag acaagggtaa aacagtcgaa gtgggtcgtg cctattttga aacagaaagg      840

aaacatttca caattttaga tgcccctggc cacaagagtt ttgtcccaaa tatgattggt      900

ggtgcttctc aagctgattt ggctgtgctg gtcatctctg ccaggaaagg agagtttgaa      960

actggatttg aaaaaggtgg acagacaaga gaacatgcga tgttggcaaa aacggcaggg     1020

gtaaaacatt taatagtgct tattaataag atggatgatc ccacagtaaa ttggagcatc     1080

gagagatatg aagaatgtaa agaaaaactg gtgccctttt tgaaaaaagt aggcttcagt     1140

ccaaaaaagg acattcactt tatgccctgc tcaggactga ccggagcaaa tattaaagag     1200

cagtcagatt tctgcccttg gtacactgga ttaccattta ttccgtattt ggataacttg     1260

ccaaacttca acagatcaat tgatggacca ataagactgc caattgtgga taagtacaaa     1320

gatatgggca ccgtggtcct gggaaagctg gaatccgggt ccatttttaa aggccagcag     1380

ctcgtgatga tgccaaacaa gcacaatgta gaagttcttg gaatactttc tgatgatact     1440

gaaactgatt ttgtagcccc aggtgaaaac ctcaaaatca gactgaaggg aattgaagaa     1500

gaagagattc ttccaggatt catactttgt gatcctagta acctctgcca ttctggacgc     1560

acgtttgatg ttcagatagt gattattgag cacaaatcca tcatctgccc aggttataat     1620

gcggtgctgc acattcatac ttgtattgag gaagttgaga taacagcgtt aatctccttg     1680

gtagacaaaa aatcaggaga aaaaagtaag acacgacccc gcttcgtgaa acaagatcaa     1740

gtatgcattg ctcgtttaag gacagcagga accatctgcc tcgagacgtt caaagatttt     1800

cctcagatgg gtcgttttac tttaagagat gagggtaaga ccattgcaat tggaaaagtt     1860

ctgaaattgg tcccagagaa ggactaa                                         1887


<210>  42
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Asp Ser Gly Ser Ser Ser Ser Asp Ser Ala Pro Asp Cys Trp Asp 
1               5                   10                  15      


Gln Val Asp Met Glu Ser Pro Gly Ser Ala Pro Ser Gly Asp Gly Val 
            20                  25                  30          


Ser Ser Ala Val Ala Glu Ala Gln Arg Glu Pro Leu Ser Ser Ala Phe 
        35                  40                  45              


Ser Arg Lys Leu Asn Val Asn Ala Lys Pro Phe Val Pro Asn Val His 
    50                  55                  60                  


Ala Ala Glu Phe Val Pro Ser Phe Leu Arg Gly Pro Thr Gln Pro Pro 
65                  70                  75                  80  


Thr Leu Pro Ala Gly Ser Gly Ser Asn Asp Glu Thr Cys Thr Gly Ala 
                85                  90                  95      


Gly Tyr Pro Gln Gly Lys Arg Met Gly Arg Gly Ala Pro Val Glu Pro 
            100                 105                 110         


Ser Arg Glu Glu Pro Leu Val Ser Leu Glu Gly Ser Asn Ser Ala Val 
        115                 120                 125             


Thr Met Glu Leu Ser Glu Pro Val Val Glu Asn Gly Glu Val Glu Met 
    130                 135                 140                 


Ala Leu Glu Glu Ser Trp Glu His Ser Lys Glu Val Ser Glu Ala Glu 
145                 150                 155                 160 


Pro Gly Gly Gly Ser Ser Gly Asp Ser Gly Pro Pro Glu Glu Ser Gly 
                165                 170                 175     


Gln Glu Met Met Glu Glu Lys Glu Glu Ile Arg Lys Ser Lys Ser Val 
            180                 185                 190         


Ile Val Pro Ser Gly Ala Pro Lys Lys Glu His Val Asn Val Val Phe 
        195                 200                 205             


Ile Gly His Val Asp Ala Gly Lys Ser Thr Ile Gly Gly Gln Ile Met 
    210                 215                 220                 


Phe Leu Thr Gly Met Val Asp Lys Arg Thr Leu Glu Lys Tyr Glu Arg 
225                 230                 235                 240 


Glu Ala Lys Glu Lys Asn Arg Glu Thr Trp Tyr Leu Ser Trp Ala Leu 
                245                 250                 255     


Asp Thr Asn Gln Glu Glu Arg Asp Lys Gly Lys Thr Val Glu Val Gly 
            260                 265                 270         


Arg Ala Tyr Phe Glu Thr Glu Arg Lys His Phe Thr Ile Leu Asp Ala 
        275                 280                 285             


Pro Gly His Lys Ser Phe Val Pro Asn Met Ile Gly Gly Ala Ser Gln 
    290                 295                 300                 


Ala Asp Leu Ala Val Leu Val Ile Ser Ala Arg Lys Gly Glu Phe Glu 
305                 310                 315                 320 


Thr Gly Phe Glu Lys Gly Gly Gln Thr Arg Glu His Ala Met Leu Ala 
                325                 330                 335     


Lys Thr Ala Gly Val Lys His Leu Ile Val Leu Ile Asn Lys Met Asp 
            340                 345                 350         


Asp Pro Thr Val Asn Trp Ser Ile Glu Arg Tyr Glu Glu Cys Lys Glu 
        355                 360                 365             


Lys Leu Val Pro Phe Leu Lys Lys Val Gly Phe Ser Pro Lys Lys Asp 
    370                 375                 380                 


Ile His Phe Met Pro Cys Ser Gly Leu Thr Gly Ala Asn Ile Lys Glu 
385                 390                 395                 400 


Gln Ser Asp Phe Cys Pro Trp Tyr Thr Gly Leu Pro Phe Ile Pro Tyr 
                405                 410                 415     


Leu Asp Asn Leu Pro Asn Phe Asn Arg Ser Ile Asp Gly Pro Ile Arg 
            420                 425                 430         


Leu Pro Ile Val Asp Lys Tyr Lys Asp Met Gly Thr Val Val Leu Gly 
        435                 440                 445             


Lys Leu Glu Ser Gly Ser Ile Phe Lys Gly Gln Gln Leu Val Met Met 
    450                 455                 460                 


Pro Asn Lys His Asn Val Glu Val Leu Gly Ile Leu Ser Asp Asp Thr 
465                 470                 475                 480 


Glu Thr Asp Phe Val Ala Pro Gly Glu Asn Leu Lys Ile Arg Leu Lys 
                485                 490                 495     


Gly Ile Glu Glu Glu Glu Ile Leu Pro Gly Phe Ile Leu Cys Asp Pro 
            500                 505                 510         


Ser Asn Leu Cys His Ser Gly Arg Thr Phe Asp Val Gln Ile Val Ile 
        515                 520                 525             


Ile Glu His Lys Ser Ile Ile Cys Pro Gly Tyr Asn Ala Val Leu His 
    530                 535                 540                 


Ile His Thr Cys Ile Glu Glu Val Glu Ile Thr Ala Leu Ile Ser Leu 
545                 550                 555                 560 


Val Asp Lys Lys Ser Gly Glu Lys Ser Lys Thr Arg Pro Arg Phe Val 
                565                 570                 575     


Lys Gln Asp Gln Val Cys Ile Ala Arg Leu Arg Thr Ala Gly Thr Ile 
            580                 585                 590         


Cys Leu Glu Thr Phe Lys Asp Phe Pro Gln Met Gly Arg Phe Thr Leu 
        595                 600                 605             


Arg Asp Glu Gly Lys Thr Ile Ala Ile Gly Lys Val Leu Lys Leu Val 
    610                 615                 620                 


Pro Glu Lys Asp 
625             


<210>  43
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  43
atgcccctca acgttagctt caccaacagg aactatgacc tcgactacga ctcggtgcag       60

ccgtatttct actgcgacga ggaggagaac ttctaccagc agcagcagca gagcgagctg      120

cagcccccgg cgcccagcga ggatatctgg aagaaattcg agctgctgcc caccccgccc      180

ctgtccccta gccgccgctc cgggctctgc tcgccctcct acgttgcggt cacacccttc      240

tcccttcggg gagacaacga cggcggtggc gggagcttct ccacggccga ccagctggag      300

atggtgaccg agctgctggg aggagacatg gtgaaccaga gtttcatctg cgacccggac      360

gacgagacct tcatcaaaaa catcatcatc caggactgta tgtggagcgg cttctcggcc      420

gccgccaagc tcgtctcaga gaagctggcc tcctaccagg ctgcgcgcaa agacagcggc      480

agcccgaacc ccgcccgcgg ccacagcgtc tgctccacct ccagcttgta cctgcaggat      540

ctgagcgccg ccgcctcaga gtgcatcgac ccctcggtgg tcttccccta ccctctcaac      600

gacagcagct cgcccaagtc ctgcgcctcg caagactcca gcgccttctc tccgtcctcg      660

gattctctgc tctcctcgac ggagtcctcc ccgcagggca gccccgagcc cctggtgctc      720

catgaggaga caccgcccac caccagcagc gactctgagg aggaacaaga agatgaggaa      780

gaaatcgatg ttgtttctgt ggaaaagagg caggctcctg gcaaaaggtc agagtctgga      840

tcaccttctg ctggaggcca cagcaaacct cctcacagcc cactggtcct caagaggtgc      900

cacgtctcca cacatcagca caactacgca gcgcctccct ccactcggaa ggactatcct      960

gctgccaaga gggtcaagtt ggacagtgtc agagtcctga gacagatcag caacaaccga     1020

aaatgcacca gccccaggtc ctcggacacc gaggagaatg tcaagaggcg aacacacaac     1080

gtcttggagc gccagaggag gaacgagcta aaacggagct tttttgccct gcgtgaccag     1140

atcccggagt tggaaaacaa tgaaaaggcc cccaaggtag ttatccttaa aaaagccaca     1200

gcatacatcc tgtccgtcca agcagaggag caaaagctca tttctgaaga ggacttgttg     1260

cggaaacgac gagaacagtt gaaacacaaa cttgaacagc tacggaactc ttgtgcgtaa     1320


<210>  44
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys Ala 
        435                 


<210>  45
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  45
ttatctttcc ggattgaaat tacc                                              24


<210>  46
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  46
ccatgtacta gacatacgat ctggg                                             25


<210>  47
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  47
aaggtaactg tatgggataa tggg                                              24


<210>  48
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  48
aattgaattg cctactgtga acc                                               23


<210>  49
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  49
acagaacatg gagtttgagg g                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  50
aagtgggtct tcctcagttg c                                                 21


<210>  51
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  51
acaaagcttg aattaaatga ggttg                                             25


<210>  52
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  52
aactaacctt atgtaaggga atttgc                                            26


<210>  53
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  53
ttctgtcttg cacatagcca tc                                                22


<210>  54
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  54
actaggcagg ccaacaggta g                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  55
actgatgctt tcccttctgt g                                                 21


<210>  56
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  56
ctggtgctgt cccatctctc                                                   20


<210>  57
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  57
agccatttct ggtggtcaaa g                                                 21


<210>  58
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  58
ttggaaagtt aatgccacgc                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  59
actctagcat gggcaacagg                                                   20


<210>  60
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  60
cccgacacat actatgccaa g                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  61
tcctgttgtg gacagaaatc c                                                 21


<210>  62
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  62
aaatttgaga accactgtta tcctg                                             25


<210>  63
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  63
taatttctgg cttccactgc c                                                 21


<210>  64
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  64
ggttctgacc aattctttcc c                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  65
tgtgcctggc tgacacaata c                                                 21


<210>  66
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  66
gccaaatgaa tggcacttac tc                                                22


<210>  67
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  67
ctgtctggcc aagtagcact g                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  68
aactgctcaa acccagactc c                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  69
gtcagcacag tggagctgaa g                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  70
ttgaccacct ctgacttcct g                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  71
tgttgtcaga ctccaagcag g                                                 21


<210>  72
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  72
gggattactg gcctggaaag                                                   20


<210>  73
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  73
gctaattagg gtggctgagg c                                                 21


<210>  74
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  74
aaacaggctt cccatcatcc                                                   20


<210>  75
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  75
cgtccagaca tcagttccat c                                                 21


<210>  76
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  76
gtgccatctc acaaaggtgg                                                   20


<210>  77
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  77
agatgtaatt gcatggccac c                                                 21


<210>  78
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  78
agggacctcg tttgttcctg                                                   20


<210>  79
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CNII helix sequence

<400>  79

Lys Lys Tyr Arg Arg 
1               5   


