                         SEQUENCE LISTING

<110>  MASSACHUSETTS INSTITUTE OF TECHNOLOGY
       Raguram, S
       Sasisekharan, Ram
       Sasisekharan, Viswanathan
       Soundararajan, Venkataramanan
       Subramanian, Vidya
       Tharakaraman, Kannan
 
<120>  AGENTS FOR INFLUENZA NEUTRALIZATION

<130>  0492612-0931

<150>  US 61/645,453
<151>  2012-05-10

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Glu Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Gln Gly Tyr Phe Asn Pro Trp Gly Ala Gly Thr Thr Leu Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  2
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Lys Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  3
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Lys Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  4
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Lys Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  5
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Lys Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  6
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Lys Asp Ser Gln Leu Arg Ser Leu Val Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  7
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  8
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Lys Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  9
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Thr Gln Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Gln Gly Phe Tyr Asp Ile Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  10
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Gln Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Gln Gly Tyr Phe Asp Pro Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  11
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  12
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Lys Asp Ser Gln Leu Arg Ser Leu Ile Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Asn Gly Tyr Phe Asp Ile Trp Gly Ala Gly Thr Thr Leu Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  13
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  13

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Asn Gly Phe Tyr Asp Ile Trp Gly Ala Gly Thr Thr Leu Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  14
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Asn Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Ser Gly Leu Leu Asp Tyr Trp Gly Ala Gly Thr Thr Leu Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  15
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Gln Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Gln Gly Tyr Phe Asp Pro Trp Gly Ala Gly Thr Thr Leu Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  16
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Thr Gln Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Gln Gly Phe Tyr Asp Ile Trp Gly Ala Gly Thr Thr Leu Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 1

<400>  17

Gly Phe Thr Phe Thr Ser Tyr 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 1

<400>  18

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 2

<400>  19

Ser Tyr Asp Gly Ser Tyr 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 2

<400>  20

Ser Tyr Asp Gly Ser Asn 
1               5       


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  21

Asp Ser Glu Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser Gln Gly 
1               5                   10                  15      


Tyr Phe Asn Pro 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  22

Asp Gly Lys Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser Ser Gly 
1               5                   10                  15      


Leu Leu Asp Tyr 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  23

Asp Ser Gln Leu Arg Ser Leu Val Tyr Phe Glu Trp Leu Ser Ser Gly 
1               5                   10                  15      


Leu Leu Asp Tyr 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  24

Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser Ser Gly 
1               5                   10                  15      


Leu Leu Asp Tyr 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  25

Asp Thr Gln Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser Gln Gly 
1               5                   10                  15      


Phe Tyr Asp Ile 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  26

Asp Ser Gln Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser Gln Gly 
1               5                   10                  15      


Tyr Phe Asp Pro 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  27

Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser Ser Gly 
1               5                   10                  15      


Leu Leu Asp Tyr 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  28

Asp Ser Gln Leu Arg Ser Leu Ile Tyr Phe Glu Trp Leu Ser Asn Gly 
1               5                   10                  15      


Tyr Phe Asp Ile 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  29

Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser Asn Gly 
1               5                   10                  15      


Phe Tyr Asp Ile 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  30

Asp Ser Asn Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser Ser Gly 
1               5                   10                  15      


Leu Leu Asp Tyr 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  31

Asp Ser Gln Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser Gln Gly 
1               5                   10                  15      


Tyr Phe Asp Pro 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VH Chain CDR 3

<400>  32

Asp Thr Gln Leu Arg Thr Ile Val Tyr Phe Glu Trp Leu Ser Gln Gly 
1               5                   10                  15      


Phe Tyr Asp Ile 
            20  


<210>  33
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  33

Glu Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Thr Tyr Asn 
            20                  25                  30          


Tyr Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr 
                85                  90                  95      


Arg Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  34
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            100                 105                 


<210>  35
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Pro Arg Ser 
            20                  25                  30          


Ile Ser Gly Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Trp Gly Ser Tyr Leu Tyr Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  36
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Pro Phe Ser 
            20                  25                  30          


Tyr Lys Gly Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Trp Gly Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  37
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Phe Asp 
            20                  25                  30          


Tyr Lys Asn Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Trp Gly Ser Tyr Leu Glu Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            100                 105                 110         


<210>  38
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Phe Asn 
            20                  25                  30          


Tyr Lys Asn Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Trp Gly Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  39
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Phe Ser 
            20                  25                  30          


Tyr Lys Asn Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Trp Gly Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  40
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Pro Phe Ser 
            20                  25                  30          


Tyr Lys Gly Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Trp Gly Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  41
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Phe Asp 
            20                  25                  30          


Tyr Lys Asn Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Trp Gly Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  42
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Phe Asn 
            20                  25                  30          


Tyr Lys Asn Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Trp Gly Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  43
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Phe Ser 
            20                  25                  30          


Tyr Lys Asn Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Trp Gly Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser 
    


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  44

Lys Ser Ser Gln Ser Val Thr Tyr Asn Tyr Lys Asn Tyr Leu Ala 
1               5                   10                  15  


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  45

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  46

Arg Ala Ser Gln Asp Ile Pro Arg Ser Ile Ser Gly Tyr Val Ala 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  47

Arg Ala Ser Gln Asp Ile Pro Phe Ser Tyr Lys Gly Tyr Val Ala 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  48

Arg Ala Ser Gln Ser Ile Thr Phe Asp Tyr Lys Asn Tyr Val Ala 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  49

Arg Ala Ser Gln Ser Ile Thr Phe Asn Tyr Lys Asn Tyr Val Ala 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  50

Arg Ala Ser Gln Ser Ile Thr Phe Ser Tyr Lys Asn Tyr Val Ala 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  51

Arg Ala Ser Gln Asp Ile Pro Phe Ser Tyr Lys Gly Tyr Val Ala 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  52

Arg Ala Ser Gln Ser Ile Thr Phe Asp Tyr Lys Asn Tyr Val Ala 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  53

Arg Ala Ser Gln Ser Ile Thr Phe Asn Tyr Lys Asn Tyr Val Ala 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 1

<400>  54

Arg Ala Ser Gln Ser Ile Thr Phe Ser Tyr Lys Asn Tyr Val Ala 
1               5                   10                  15  


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 2

<400>  55

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 2

<400>  56

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 2

<400>  57

Trp Gly Ser Tyr Leu Tyr Ser 
1               5           


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 2

<400>  58

Trp Gly Ser Tyr Leu Glu 
1               5       


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 3

<400>  59

Gln Gln Tyr Tyr Arg Thr Pro Pro Thr 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary VL Chain CDR 3

<400>  60

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


