                         SEQUENCE LISTING

<110>  ProRec AB
 
<120>  Method for diagnosis and treatment of prolactin associated 
       disorders

<130>  P3254PC00

<150>  US 61/646,086
<151>  2012-05-11

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  622
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(622)
<223>  Prolactin receptor (PrlR)

<400>  1

Met Lys Glu Asn Val Ala Ser Ala Thr Val Phe Thr Leu Leu Leu Phe 
1               5                   10                  15      


Leu Asn Thr Cys Leu Leu Asn Gly Gln Leu Pro Pro Gly Lys Pro Glu 
            20                  25                  30          


Ile Phe Lys Cys Arg Ser Pro Asn Lys Glu Thr Phe Thr Cys Trp Trp 
        35                  40                  45              


Arg Pro Gly Thr Asp Gly Gly Leu Pro Thr Asn Tyr Ser Leu Thr Tyr 
    50                  55                  60                  


His Arg Glu Gly Glu Thr Leu Met His Glu Cys Pro Asp Tyr Ile Thr 
65                  70                  75                  80  


Gly Gly Pro Asn Ser Cys His Phe Gly Lys Gln Tyr Thr Ser Met Trp 
                85                  90                  95      


Arg Thr Tyr Ile Met Met Val Asn Ala Thr Asn Gln Met Gly Ser Ser 
            100                 105                 110         


Phe Ser Asp Glu Leu Tyr Val Asp Val Thr Tyr Ile Val Gln Pro Asp 
        115                 120                 125             


Pro Pro Leu Glu Leu Ala Val Glu Val Lys Gln Pro Glu Asp Arg Lys 
    130                 135                 140                 


Pro Tyr Leu Trp Ile Lys Trp Ser Pro Pro Thr Leu Ile Asp Leu Lys 
145                 150                 155                 160 


Thr Gly Trp Phe Thr Leu Leu Tyr Glu Ile Arg Leu Lys Pro Glu Lys 
                165                 170                 175     


Ala Ala Glu Trp Glu Ile His Phe Ala Gly Gln Gln Thr Glu Phe Lys 
            180                 185                 190         


Ile Leu Ser Leu His Pro Gly Gln Lys Tyr Leu Val Gln Val Arg Cys 
        195                 200                 205             


Lys Pro Asp His Gly Tyr Trp Ser Ala Trp Ser Pro Ala Thr Phe Ile 
    210                 215                 220                 


Gln Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr Val Trp Ile Ser 
225                 230                 235                 240 


Val Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile Val Trp Ala Val 
                245                 250                 255     


Ala Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro 
            260                 265                 270         


Gly Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys 
        275                 280                 285             


Ser Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr 
    290                 295                 300                 


Ser Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ser 
305                 310                 315                 320 


Glu Asp Gln His Leu Met Ser Val His Ser Lys Glu His Pro Ser Gln 
                325                 330                 335     


Gly Met Lys Pro Thr Tyr Leu Asp Pro Asp Thr Asp Ser Gly Arg Gly 
            340                 345                 350         


Ser Cys Asp Ser Pro Ser Leu Leu Ser Glu Lys Cys Glu Glu Pro Gln 
        355                 360                 365             


Ala Asn Pro Ser Thr Phe Tyr Asp Pro Glu Val Ile Glu Lys Pro Glu 
    370                 375                 380                 


Asn Pro Glu Thr Thr His Thr Trp Asp Pro Gln Cys Ile Ser Met Glu 
385                 390                 395                 400 


Gly Lys Ile Pro Tyr Phe His Ala Gly Gly Ser Lys Cys Ser Thr Trp 
                405                 410                 415     


Pro Leu Pro Gln Pro Ser Gln His Asn Pro Arg Ser Ser Tyr His Asn 
            420                 425                 430         


Ile Thr Asp Val Cys Glu Leu Ala Val Gly Pro Ala Gly Ala Pro Ala 
        435                 440                 445             


Thr Leu Leu Asn Glu Ala Gly Lys Asp Ala Leu Lys Ser Ser Gln Thr 
    450                 455                 460                 


Ile Lys Ser Arg Glu Glu Gly Lys Ala Thr Gln Gln Arg Glu Val Glu 
465                 470                 475                 480 


Ser Phe His Ser Glu Thr Asp Gln Asp Thr Pro Trp Leu Leu Pro Gln 
                485                 490                 495     


Glu Lys Thr Pro Phe Gly Ser Ala Lys Pro Leu Asp Tyr Val Glu Ile 
            500                 505                 510         


His Lys Val Asn Lys Asp Gly Ala Leu Ser Leu Leu Pro Lys Gln Arg 
        515                 520                 525             


Glu Asn Ser Gly Lys Pro Lys Lys Pro Gly Thr Pro Glu Asn Asn Lys 
    530                 535                 540                 


Glu Tyr Ala Lys Val Ser Gly Val Met Asp Asn Asn Ile Leu Val Leu 
545                 550                 555                 560 


Val Pro Asp Pro His Ala Lys Asn Val Ala Cys Phe Glu Glu Ser Ala 
                565                 570                 575     


Lys Glu Ala Pro Pro Ser Leu Glu Gln Asn Gln Ala Glu Lys Ala Leu 
            580                 585                 590         


Ala Asn Phe Thr Ala Thr Ser Ser Lys Cys Arg Leu Gln Leu Gly Gly 
        595                 600                 605             


Leu Asp Tyr Leu Asp Pro Ala Cys Phe Thr His Ser Phe His 
    610                 615                 620         


<210>  2
<211>  638
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(638)
<223>  Growth Hormone Receptor (GHR)

<400>  2

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
        515                 520                 525             


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 635             


<210>  3
<211>  198
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(198)
<223>  Suppressor Of Cytokine Signalling 2 (SOCS2)

<400>  3

Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210>  4
<211>  1807
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1807)
<223>  Tuberin / Tuberous sclerosis 2 protein (TCS2)

<400>  4

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Ser Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser 
945                 950                 955                 960 


Pro Pro Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg 
                965                 970                 975     


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            980                 985                 990         


Thr Ser Leu Thr Ser Ala Ser Leu  Gly Ser Ala Asp Glu  Asn Ser Val 
        995                 1000                 1005             


Ala Gln  Ala Asp Asp Ser Leu  Lys Asn Leu His Leu  Glu Leu Thr 
    1010                 1015                 1020             


Glu Thr  Cys Leu Asp Met Met  Ala Arg Tyr Val Phe  Ser Asn Phe 
    1025                 1030                 1035             


Thr Ala  Val Pro Lys Arg Ser  Pro Val Gly Glu Phe  Leu Leu Ala 
    1040                 1045                 1050             


Gly Gly  Arg Thr Lys Thr Trp  Leu Val Gly Asn Lys  Leu Val Thr 
    1055                 1060                 1065             


Val Thr  Thr Ser Val Gly Thr  Gly Thr Arg Ser Leu  Leu Gly Leu 
    1070                 1075                 1080             


Asp Ser  Gly Glu Leu Gln Ser  Gly Pro Glu Ser Ser  Ser Ser Pro 
    1085                 1090                 1095             


Gly Val  His Val Arg Gln Thr  Lys Glu Ala Pro Ala  Lys Leu Glu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Gln Gln Val  Ser Arg Gly Ala Arg  Asp Arg Val 
    1115                 1120                 1125             


Arg Ser  Met Ser Gly Gly His  Gly Leu Arg Val Gly  Ala Leu Asp 
    1130                 1135                 1140             


Val Pro  Ala Ser Gln Phe Leu  Gly Ser Ala Thr Ser  Pro Gly Pro 
    1145                 1150                 1155             


Arg Thr  Ala Pro Ala Ala Lys  Pro Glu Lys Ala Ser  Ala Gly Thr 
    1160                 1165                 1170             


Arg Val  Pro Val Gln Glu Lys  Thr Asn Leu Ala Ala  Tyr Val Pro 
    1175                 1180                 1185             


Leu Leu  Thr Gln Gly Trp Ala  Glu Ile Leu Val Arg  Arg Pro Thr 
    1190                 1195                 1200             


Gly Asn  Thr Ser Trp Leu Met  Ser Leu Glu Asn Pro  Leu Ser Pro 
    1205                 1210                 1215             


Phe Ser  Ser Asp Ile Asn Asn  Met Pro Leu Gln Glu  Leu Ser Asn 
    1220                 1225                 1230             


Ala Leu  Met Ala Ala Glu Arg  Phe Lys Glu His Arg  Asp Thr Ala 
    1235                 1240                 1245             


Leu Tyr  Lys Ser Leu Ser Val  Pro Ala Ala Ser Thr  Ala Lys Pro 
    1250                 1255                 1260             


Pro Pro  Leu Pro Arg Ser Asn  Thr Val Ala Ser Phe  Ser Ser Leu 
    1265                 1270                 1275             


Tyr Gln  Ser Ser Cys Gln Gly  Gln Leu His Arg Ser  Val Ser Trp 
    1280                 1285                 1290             


Ala Asp  Ser Ala Val Val Met  Glu Glu Gly Ser Pro  Gly Glu Val 
    1295                 1300                 1305             


Pro Val  Leu Val Glu Pro Pro  Gly Leu Glu Asp Val  Glu Ala Ala 
    1310                 1315                 1320             


Leu Gly  Met Asp Arg Arg Thr  Asp Ala Tyr Ser Arg  Ser Ser Ser 
    1325                 1330                 1335             


Val Ser  Ser Gln Glu Glu Lys  Ser Leu His Ala Glu  Glu Leu Val 
    1340                 1345                 1350             


Gly Arg  Gly Ile Pro Ile Glu  Arg Val Val Ser Ser  Glu Gly Gly 
    1355                 1360                 1365             


Arg Pro  Ser Val Asp Leu Ser  Phe Gln Pro Ser Gln  Pro Leu Ser 
    1370                 1375                 1380             


Lys Ser  Ser Ser Ser Pro Glu  Leu Gln Thr Leu Gln  Asp Ile Leu 
    1385                 1390                 1395             


Gly Asp  Pro Gly Asp Lys Ala  Asp Val Gly Arg Leu  Ser Pro Glu 
    1400                 1405                 1410             


Val Lys  Ala Arg Ser Gln Ser  Gly Thr Leu Asp Gly  Glu Ser Ala 
    1415                 1420                 1425             


Ala Trp  Ser Ala Ser Gly Glu  Asp Ser Arg Gly Gln  Pro Glu Gly 
    1430                 1435                 1440             


Pro Leu  Pro Ser Ser Ser Pro  Arg Ser Pro Ser Gly  Leu Arg Pro 
    1445                 1450                 1455             


Arg Gly  Tyr Thr Ile Ser Asp  Ser Ala Pro Ser Arg  Arg Gly Lys 
    1460                 1465                 1470             


Arg Val  Glu Arg Asp Ala Leu  Lys Ser Arg Ala Thr  Ala Ser Asn 
    1475                 1480                 1485             


Ala Glu  Lys Val Pro Gly Ile  Asn Pro Ser Phe Val  Phe Leu Gln 
    1490                 1495                 1500             


Leu Tyr  His Ser Pro Phe Phe  Gly Asp Glu Ser Asn  Lys Pro Ile 
    1505                 1510                 1515             


Leu Leu  Pro Asn Glu Ser Gln  Ser Phe Glu Arg Ser  Val Gln Leu 
    1520                 1525                 1530             


Leu Asp  Gln Ile Pro Ser Tyr  Asp Thr His Lys Ile  Ala Val Leu 
    1535                 1540                 1545             


Tyr Val  Gly Glu Gly Gln Ser  Asn Ser Glu Leu Ala  Ile Leu Ser 
    1550                 1555                 1560             


Asn Glu  His Gly Ser Tyr Arg  Tyr Thr Glu Phe Leu  Thr Gly Leu 
    1565                 1570                 1575             


Gly Arg  Leu Ile Glu Leu Lys  Asp Cys Gln Pro Asp  Lys Val Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Leu Asp Val Cys  Gly Glu Asp Gly Gln  Phe Thr Tyr 
    1595                 1600                 1605             


Cys Trp  His Asp Asp Ile Met  Gln Ala Val Phe His  Ile Ala Thr 
    1610                 1615                 1620             


Leu Met  Pro Thr Lys Asp Val  Asp Lys His Arg Cys  Asp Lys Lys 
    1625                 1630                 1635             


Arg His  Leu Gly Asn Asp Phe  Val Ser Ile Val Tyr  Asn Asp Ser 
    1640                 1645                 1650             


Gly Glu  Asp Phe Lys Leu Gly  Thr Ile Lys Gly Gln  Phe Asn Phe 
    1655                 1660                 1665             


Val His  Val Ile Val Thr Pro  Leu Asp Tyr Glu Cys  Asn Leu Val 
    1670                 1675                 1680             


Ser Leu  Gln Cys Arg Lys Asp  Met Glu Gly Leu Val  Asp Thr Ser 
    1685                 1690                 1695             


Val Ala  Lys Ile Val Ser Asp  Arg Asn Leu Pro Phe  Val Ala Arg 
    1700                 1705                 1710             


Gln Met  Ala Leu His Ala Asn  Met Ala Ser Gln Val  His His Ser 
    1715                 1720                 1725             


Arg Ser  Asn Pro Thr Asp Ile  Tyr Pro Ser Lys Trp  Ile Ala Arg 
    1730                 1735                 1740             


Leu Arg  His Ile Lys Arg Leu  Arg Gln Arg Ile Cys  Glu Glu Ala 
    1745                 1750                 1755             


Ala Tyr  Ser Asn Pro Ser Leu  Pro Leu Val His Pro  Pro Ser His 
    1760                 1765                 1770             


Ser Lys  Ala Pro Ala Gln Thr  Pro Ala Glu Pro Thr  Pro Gly Tyr 
    1775                 1780                 1785             


Glu Val  Gly Gln Arg Lys Arg  Leu Ile Ser Ser Val  Glu Asp Phe 
    1790                 1795                 1800             


Thr Glu  Phe Val 
    1805         


<210>  5
<211>  227
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(227)
<223>  wtPrl including signal peptide

<400>  5

Met Asn Ile Lys Gly Ser Pro Trp Lys Gly Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Ser Asn Leu Leu Leu Cys Gln Ser Val Ala Pro Leu Pro Ile Cys 
            20                  25                  30          


Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 
        35                  40                  45              


Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met 
    50                  55                  60                  


Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr 
65                  70                  75                  80  


Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp 
                85                  90                  95      


Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile 
            100                 105                 110         


Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr 
        115                 120                 125             


Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala 
    130                 135                 140                 


Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Gly Met Glu Leu 
145                 150                 155                 160 


Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 
                165                 170                 175     


Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg 
            180                 185                 190         


Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His 
        195                 200                 205             


Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg Ile Ile His Asn 
    210                 215                 220                 


Asn Asn Cys 
225         


<210>  6
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(199)
<223>  Mature wt-Prl

<400>  6

Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg 
1               5                   10                  15      


Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu 
            20                  25                  30          


Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg 
        35                  40                  45              


Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala 
    50                  55                  60                  


Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr 
                85                  90                  95      


His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile 
            100                 105                 110         


Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu 
        115                 120                 125             


Gly Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn 
    130                 135                 140                 


Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp 
145                 150                 155                 160 


Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg 
                165                 170                 175     


Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg 
            180                 185                 190         


Ile Ile His Asn Asn Asn Cys 
        195                 


<210>  7
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(199)
<223>  Mature Prl (mutated S33A , Q73L, G129R, K190R)

<400>  7

Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg 
1               5                   10                  15      


Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu 
            20                  25                  30          


Ala Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg 
        35                  40                  45              


Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala 
    50                  55                  60                  


Thr Pro Glu Asp Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr 
                85                  90                  95      


His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile 
            100                 105                 110         


Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu 
        115                 120                 125             


Arg Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn 
    130                 135                 140                 


Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp 
145                 150                 155                 160 


Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg 
                165                 170                 175     


Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg 
            180                 185                 190         


Ile Ile His Asn Asn Asn Cys 
        195                 


<210>  8
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(199)
<223>  Mature Prl (mutated S61A, D68N, Q73L, G129R, K190R)

<400>  8

Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg 
1               5                   10                  15      


Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu 
            20                  25                  30          


Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg 
        35                  40                  45              


Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala 
    50                  55                  60                  


Thr Pro Glu Asn Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr 
                85                  90                  95      


His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile 
            100                 105                 110         


Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu 
        115                 120                 125             


Arg Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn 
    130                 135                 140                 


Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp 
145                 150                 155                 160 


Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg 
                165                 170                 175     


Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg 
            180                 185                 190         


Ile Ile His Asn Asn Asn Cys 
        195                 


<210>  9
<211>  191
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(191)
<223>  Mature Growth Hormone (wild-type)

<400>  9

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     


<210>  10
<211>  191
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(191)
<223>  Growth Hormone (mutated G120R)

<400>  10

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Arg Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  11

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  12

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  13

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  15

Glu Phe Ala Gly Ala Ala Ala Val 
1               5               


<210>  16
<211>  198
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(198)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  16

Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp 
1               5                   10                  15      


Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala 
            20                  25                  30          


Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly 
        35                  40                  45              


Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr 
    50                  55                  60                  


Pro Glu Asp Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu 
65                  70                  75                  80  


Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His 
                85                  90                  95      


Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu 
            100                 105                 110         


Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg 
        115                 120                 125             


Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu 
    130                 135                 140                 


Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu 
145                 150                 155                 160 


Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg 
                165                 170                 175     


Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile 
            180                 185                 190         


Ile His Asn Asn Asn Cys 
        195             


<210>  17
<211>  197
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(197)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  17

Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu 
1               5                   10                  15      


Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser 
            20                  25                  30          


Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe 
        35                  40                  45              


Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro 
    50                  55                  60                  


Glu Asp Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser 
65                  70                  75                  80  


Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu 
                85                  90                  95      


Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser 
            100                 105                 110         


Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met 
        115                 120                 125             


Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile 
    130                 135                 140                 


Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu 
145                 150                 155                 160 


Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp 
                165                 170                 175     


Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile 
            180                 185                 190         


His Asn Asn Asn Cys 
        195         


<210>  18
<211>  196
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(196)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  18

Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe 
1               5                   10                  15      


Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu 
            20                  25                  30          


Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile 
        35                  40                  45              


Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu 
    50                  55                  60                  


Asp Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu 
65                  70                  75                  80  


Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val 
                85                  90                  95      


Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys 
            100                 105                 110         


Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu 
        115                 120                 125             


Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr 
    130                 135                 140                 


Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser 
145                 150                 155                 160 


Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser 
                165                 170                 175     


His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His 
            180                 185                 190         


Asn Asn Asn Cys 
        195     


<210>  19
<211>  195
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(195)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  19

Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 
1               5                   10                  15      


Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met 
            20                  25                  30          


Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr 
        35                  40                  45              


Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp 
    50                  55                  60                  


Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile 
65                  70                  75                  80  


Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr 
                85                  90                  95      


Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala 
            100                 105                 110         


Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu 
        115                 120                 125             


Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 
    130                 135                 140                 


Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg 
145                 150                 155                 160 


Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His 
                165                 170                 175     


Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn 
            180                 185                 190         


Asn Asn Cys 
        195 


<210>  20
<211>  194
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(194)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  20

Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg 
1               5                   10                  15      


Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe 
            20                  25                  30          


Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys 
        35                  40                  45              


Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys 
    50                  55                  60                  


Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val 
65                  70                  75                  80  


Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu 
                85                  90                  95      


Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val 
            100                 105                 110         


Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile 
        115                 120                 125             


Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val 
    130                 135                 140                 


Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu 
145                 150                 155                 160 


Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys 
                165                 170                 175     


Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn 
            180                 185                 190         


Asn Cys 
        


<210>  21
<211>  193
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(193)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  21

Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala 
1               5                   10                  15      


Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser 
            20                  25                  30          


Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala 
        35                  40                  45              


Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu 
    50                  55                  60                  


Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser 
65                  70                  75                  80  


Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val 
                85                  90                  95      


Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu 
            100                 105                 110         


Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val 
        115                 120                 125             


Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp 
    130                 135                 140                 


Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser 
145                 150                 155                 160 


Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile 
                165                 170                 175     


Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn 
            180                 185                 190         


Cys 
    


<210>  22
<211>  192
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(192)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  22

Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val 
1               5                   10                  15      


Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu 
            20                  25                  30          


Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile 
        35                  40                  45              


Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln 
    50                  55                  60                  


Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile 
65                  70                  75                  80  


Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg 
                85                  90                  95      


Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile 
            100                 105                 110         


Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser 
        115                 120                 125             


Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser 
    130                 135                 140                 


Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala 
145                 150                 155                 160 


Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp 
                165                 170                 175     


Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190         


<210>  23
<211>  191
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(191)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  23

Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val 
1               5                   10                  15      


Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu Phe 
            20                  25                  30          


Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn 
        35                  40                  45              


Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln Ala 
    50                  55                  60                  


Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu 
65                  70                  75                  80  


Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly 
                85                  90                  95      


Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu 
            100                 105                 110         


Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln 
        115                 120                 125             


Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly 
    130                 135                 140                 


Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr 
145                 150                 155                 160 


Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn 
                165                 170                 175     


Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190     


<210>  24
<211>  190
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(190)
<223>  N-terminally truncated Prl (mutated S33A , Q73L, G129R, K190R)

<400>  24

Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu 
1               5                   10                  15      


Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu Phe Asp 
            20                  25                  30          


Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser 
        35                  40                  45              


Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln Ala Leu 
    50                  55                  60                  


Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg 
65                  70                  75                  80  


Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met 
                85                  90                  95      


Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu 
            100                 105                 110         


Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val 
        115                 120                 125             


His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu 
    130                 135                 140                 


Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr 
145                 150                 155                 160 


Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr 
                165                 170                 175     


Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190 


<210>  25
<211>  198
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(198)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  25

Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp 
1               5                   10                  15      


Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser 
            20                  25                  30          


Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly 
        35                  40                  45              


Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr 
    50                  55                  60                  


Pro Glu Asn Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu 
65                  70                  75                  80  


Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His 
                85                  90                  95      


Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu 
            100                 105                 110         


Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg 
        115                 120                 125             


Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu 
    130                 135                 140                 


Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu 
145                 150                 155                 160 


Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg 
                165                 170                 175     


Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile 
            180                 185                 190         


Ile His Asn Asn Asn Cys 
        195             


<210>  26
<211>  197
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(197)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  26

Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu 
1               5                   10                  15      


Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser 
            20                  25                  30          


Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe 
        35                  40                  45              


Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro 
    50                  55                  60                  


Glu Asn Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser 
65                  70                  75                  80  


Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu 
                85                  90                  95      


Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser 
            100                 105                 110         


Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met 
        115                 120                 125             


Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile 
    130                 135                 140                 


Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu 
145                 150                 155                 160 


Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp 
                165                 170                 175     


Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile 
            180                 185                 190         


His Asn Asn Asn Cys 
        195         


<210>  27
<211>  196
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(196)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  27

Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe 
1               5                   10                  15      


Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu 
            20                  25                  30          


Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile 
        35                  40                  45              


Thr Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu 
    50                  55                  60                  


Asn Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu 
65                  70                  75                  80  


Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val 
                85                  90                  95      


Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys 
            100                 105                 110         


Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu 
        115                 120                 125             


Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr 
    130                 135                 140                 


Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser 
145                 150                 155                 160 


Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser 
                165                 170                 175     


His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His 
            180                 185                 190         


Asn Asn Asn Cys 
        195     


<210>  28
<211>  195
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(195)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  28

Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 
1               5                   10                  15      


Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met 
            20                  25                  30          


Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr 
        35                  40                  45              


Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn 
    50                  55                  60                  


Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile 
65                  70                  75                  80  


Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr 
                85                  90                  95      


Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala 
            100                 105                 110         


Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu 
        115                 120                 125             


Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 
    130                 135                 140                 


Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg 
145                 150                 155                 160 


Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His 
                165                 170                 175     


Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn 
            180                 185                 190         


Asn Asn Cys 
        195 


<210>  29
<211>  194
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(194)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  29

Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg 
1               5                   10                  15      


Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe 
            20                  25                  30          


Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys 
        35                  40                  45              


Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys 
    50                  55                  60                  


Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val 
65                  70                  75                  80  


Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu 
                85                  90                  95      


Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val 
            100                 105                 110         


Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile 
        115                 120                 125             


Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val 
    130                 135                 140                 


Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu 
145                 150                 155                 160 


Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys 
                165                 170                 175     


Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn 
            180                 185                 190         


Asn Cys 
        


<210>  30
<211>  193
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(193)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  30

Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala 
1               5                   10                  15      


Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser 
            20                  25                  30          


Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala 
        35                  40                  45              


Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu 
    50                  55                  60                  


Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser 
65                  70                  75                  80  


Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val 
                85                  90                  95      


Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu 
            100                 105                 110         


Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val 
        115                 120                 125             


Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp 
    130                 135                 140                 


Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser 
145                 150                 155                 160 


Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile 
                165                 170                 175     


Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn 
            180                 185                 190         


Cys 
    


<210>  31
<211>  192
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(192)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  31

Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val 
1               5                   10                  15      


Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu 
            20                  25                  30          


Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile 
        35                  40                  45              


Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln 
    50                  55                  60                  


Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile 
65                  70                  75                  80  


Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg 
                85                  90                  95      


Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile 
            100                 105                 110         


Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser 
        115                 120                 125             


Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser 
    130                 135                 140                 


Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala 
145                 150                 155                 160 


Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp 
                165                 170                 175     


Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190         


<210>  32
<211>  191
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(191)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  32

Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val 
1               5                   10                  15      


Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe 
            20                  25                  30          


Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn 
        35                  40                  45              


Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala 
    50                  55                  60                  


Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu 
65                  70                  75                  80  


Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly 
                85                  90                  95      


Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu 
            100                 105                 110         


Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln 
        115                 120                 125             


Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly 
    130                 135                 140                 


Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr 
145                 150                 155                 160 


Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn 
                165                 170                 175     


Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190     


<210>  33
<211>  190
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(190)
<223>  N-terminally truncated Prl (mutated S61A, D68N, Q73L, G129R, 
       K190R)

<400>  33

Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu 
1               5                   10                  15      


Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe Asp 
            20                  25                  30          


Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser 
        35                  40                  45              


Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala Leu 
    50                  55                  60                  


Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg 
65                  70                  75                  80  


Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met 
                85                  90                  95      


Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu 
            100                 105                 110         


Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val 
        115                 120                 125             


His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu 
    130                 135                 140                 


Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr 
145                 150                 155                 160 


Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr 
                165                 170                 175     


Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190 


