                         SEQUENCE LISTING

<110>  Georg-August-Universitt Gttingen Stiftung ffentlichen 
       Rechts
 
<120>  Conformational-specific antibodies against Abeta oligomers

<130>  30A-122 302

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  NT4X-83 HCDR1

<400>  1

Gly Phe Asn Ile Arg Asp Thr Tyr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-83 HCDR2

<400>  2

Val Asp Pro Ala Asn Gly Asn Thr 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-83 HCDR3

<400>  3

Ala Arg Arg Ile Tyr Tyr Gly Tyr Ala Leu Phe Ala Tyr 
1               5                   10              


<210>  4
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-83 LCDR1

<400>  4

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  5
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-83 LCDR2

<400>  5

Trp Ala Ser 
1           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-83 LCDR3

<400>  6

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Tyr 
1               5                   10  


<210>  7
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-83 VH

<400>  7

Glu Val His Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Arg Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ile Tyr Tyr Gly Tyr Ala Leu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  8
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-83 VL

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  9
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-167 HCDR1

<400>  9

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  10
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-167 HCDR2

<400>  10

Met Trp Ser Gly Gly Ile Thr 
1               5           


<210>  11
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-167 HCDR3

<400>  11

Ala Arg Gly Ser Arg Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  12
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-167 LCDR1

<400>  12

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  13
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-167 LCDR2

<400>  13

Tyr Thr Ser 
1           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-167 LCDR3

<400>  14

Gln Gln Gly Asn Thr Leu Pro Pro Thr 
1               5                   


<210>  15
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-167 VH

<400>  15

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Ser Gly Gly Ile Thr Asp Phe Tyr Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Ile Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ser Arg Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Ser Val Ser Ser 
        115     


<210>  16
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  NT4X-167 VL

<400>  16

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


