                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Marasco, Wayne A.
       Sui, Jianhua
       Zhu, Quan
       Chang, De-Kuan
 
<120>  Affinity Matured Anti-CCR4 Human Monoclonal Antibodies and 
       Methods of Use

<130>  20363-065001WO

<150>  US 61/642,749
<151>  2012-05-04

<150>  US 61/785,559
<151>  2013-03-14

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  1
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agccaatgga tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaagcacc      300

tggtaccggc cgctggacta ctggggccag ggcaccctgg tgaccgtgag cagc            354


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Gln 
            20                  25                  30          


Trp Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Trp Tyr Arg Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  3
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  3
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc       60

atcaactgca agagcagcca gagcatcctg tacagcagca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagagcggcg tgcccgaccg gtttagcggc agcggctccg gcaccgactt caccctgacc      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccaccagta catcagcagc      300

tacaccttcg gccagggcac aaagctggaa atcaag                                336


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  5
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agcagctgga tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaagcacg      300

tggtatcggc cgaatgacta ctggggccag ggcaccctgg tgaccgtgag cagc            354


<210>  6
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Ser 
            20                  25                  30          


Trp Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Trp Tyr Arg Pro Asn Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  7
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  7
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc       60

atcaactgca agagcagcca gagcatcctg tacagcagca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagagcggcg tgcccgaccg gtttagcggc agcggctccg gcaccgactt caccctgacc      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccaccagta caaaagcagc      300

tacaccttcg gccagggcac aaagctggaa atcaag                                336


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Lys Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  9
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agcagctgga tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaaccacc      300

cgttatcggc ccctggacta ctggggccag ggcaccctgg tgaccgtgag cagc            354


<210>  10
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Ser 
            20                  25                  30          


Trp Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Thr Arg Tyr Arg Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  11
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  11

Gly Ala Cys Ala Thr Cys Gly Thr Gly Ala Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Ala Gly Cys Cys Cys Cys Gly Ala Cys Ala Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Cys Gly Thr Gly Ala Gly Cys Cys Thr Gly Gly Gly Cys 
        35                  40                  45              


Gly Ala Gly Cys Gly Gly Gly Cys Cys Ala Cys Cys Ala Thr Cys Ala 
    50                  55                  60                  


Ala Cys Thr Gly Cys Ala Ala Gly Ala Gly Cys Ala Gly Cys Cys Ala 
65                  70                  75                  80  


Gly Ala Gly Cys Ala Thr Cys Cys Thr Gly Thr Ala Cys Ala Gly Cys 
                85                  90                  95      


Ala Gly Cys Ala Ala Cys Cys Ala Gly Ala Ala Gly Ala Ala Cys Thr 
            100                 105                 110         


Ala Cys Cys Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala 
        115                 120                 125             


Gly Cys Ala Gly Ala Ala Gly Cys Cys Cys Gly Gly Cys Cys Ala Gly 
    130                 135                 140                 


Ala Gly Cys Cys Cys Cys Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala 
145                 150                 155                 160 


Thr Cys Thr Ala Cys Thr Gly Gly Gly Cys Cys Ala Gly Cys Ala Cys 
                165                 170                 175     


Cys Cys Gly Gly Gly Ala Gly Ala Gly Cys Gly Gly Cys Gly Thr Gly 
            180                 185                 190         


Cys Cys Cys Gly Ala Cys Cys Gly Gly Thr Thr Thr Ala Gly Cys Gly 
        195                 200                 205             


Gly Cys Ala Gly Cys Gly Gly Cys Thr Cys Cys Gly Gly Cys Ala Cys 
    210                 215                 220                 


Cys Gly Ala Cys Thr Thr Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys 
225                 230                 235                 240 


Ala Thr Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Cys Ala Gly Gly 
                245                 250                 255     


Cys Cys Gly Ala Gly Gly Ala Cys Gly Thr Gly Gly Cys Cys Gly Thr 
            260                 265                 270         


Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Cys Cys Ala Gly 
        275                 280                 285             


Thr Ala Cys Cys Gly Thr Ala Gly Cys Ala Gly Cys Thr Ala Cys Ala 
    290                 295                 300                 


Cys Cys Thr Thr Cys Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys 
305                 310                 315                 320 


Ala Ala Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys Ala Ala Gly 
                325                 330                 335     


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Arg Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  13
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agccaatata tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagactgacc      300

tattatcggc cgccggacta ctggggccag ggcaccctgg tgaccgtgag cagc            354


<210>  14
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Gln 
            20                  25                  30          


Tyr Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Tyr Tyr Arg Pro Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  15
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  15
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc       60

atcaactgca agagcagcca gagcatcctg tacagcagca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagagcggcg tgcccgaccg gtttagcggc agcggctccg gcaccgactt caccctgacc      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccaccagta ctatagcagc      300

tacaccttcg gccagggcac aaagctggaa atcaag                                336


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  17
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agcgcgtgga tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaagcacg      300

tattaccggc cgctggacta ctggggccag ggcaccctgg tgaccgtgag cagc            354


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Ala 
            20                  25                  30          


Trp Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Arg Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  19
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc       60

atcaactgca agagcagcca gagcatcctg tacagcagca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagagcggcg tgcccgaccg gtttagcggc agcggctccg gcaccgactt caccctgacc      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccaccagta catgagcagc      300

tacaccttcg gccagggcac aaagctggaa atcaag                                336


<210>  20
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Met Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR1

<400>  21

Gly Tyr Thr Phe Ala Ser Tyr Tyr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR1

<400>  22

Gly Tyr Thr Phe Ala Ser Gln Trp 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR1

<400>  23

Gly Tyr Thr Phe Ala Ser Ser Trp 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR1

<400>  24

Gly Tyr Thr Phe Ala Ser Gln Tyr 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR1

<400>  25

Gly Tyr Thr Phe Ala Ser Ala Trp 
1               5               


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain, CDR1

<400>  26

Gln Ser Ile Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR2

<400>  27

Ile Asn Pro Gly Asn Val Asn Thr 
1               5               


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain, CDR2

<400>  28

Trp Ala Ser Thr Arg Glu 
1               5       


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR3

<400>  29

Ser Thr Tyr Tyr Arg Pro Leu Asp Tyr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR3

<400>  30

Ser Thr Trp Tyr Arg Pro Leu Asp Tyr 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR3

<400>  31

Ser Thr Trp Tyr Arg Pro Asn Asp Tyr 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR3

<400>  32

Thr Thr Arg Tyr Arg Pro Leu Asp Tyr 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain, CDR3

<400>  33

Leu Thr Tyr Tyr Arg Pro Pro Asp Tyr 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain, CDR3

<400>  34

His Gln Tyr Leu Ser Ser Tyr Thr 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain, CDR3

<400>  35

His Gln Tyr Ile Ser Ser Tyr Thr 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain, CDR3

<400>  36

His Gln Tyr Lys Ser Ser Tyr Thr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain, CDR3

<400>  37

His Gln Tyr Arg Ser Ser Tyr Thr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain, CDR3

<400>  38

His Gln Tyr Tyr Ser Ser Tyr Thr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain, CDR3

<400>  39

His Gln Tyr Met Ser Ser Tyr Thr 
1               5               


<210>  40
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized primer

<400>  40
tctgagtagg tgtcattcta ttctggg                                           27


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized primer

<400>  41
cactaggggt tcctagatct ctccc                                             25


<210>  42
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized probe

<400>  42

Thr Cys Thr Thr Cys Cys Cys Ala Ala Thr Cys Cys Thr Cys Cys Cys 
1               5                   10                  15      


Cys Cys Thr Thr Gly Cys Thr Gly Thr Cys 
            20                  25      


